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https://www.readbyqxmd.com/read/28533750/characterization-of-cardiovascular-alterations-induced-by-different-chronic-cisplatin-treatments
#1
Esperanza Herradón, Cristina González, José A Uranga, Raquel Abalo, Ma I Martín, Visitacion López-Miranda
In the last years, many clinical studies have revealed that some cisplatin-treated cancer survivors have a significantly increased risk of cardiovascular events, being cisplatin-induced cardiovascular toxicity an increasing concern. The aim of the present work was to evaluate the cardiovascular alterations induced by different chronic cisplatin treatments, and to identify some of the mechanisms involved. Direct blood pressure, basal cardiac (left ventricle and coronary arteries) and vascular (aortic and mesenteric) functions were evaluated in chronic (5 weeks) saline- or cisplatin-treated male Wistar rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28527428/physicochemical-and-biological-interactions-between-cerium-oxide-nanoparticles-and-a-1-8-naphthalimide-derivative
#2
Gerardo Pulido-Reyes, Esperanza Martín, J L Gu Coronado, Francisco Leganes, Roberto Rosal, Francisca Fernández-Piñas
Cerium (Ce) oxide nanoparticles (CNPs) have attracted attention due to their high bioactivity and unique redox-chemistry. The oxygen vacancies at the surface of the nanoparticle explain the autocatalytic properties of CNPs in which the Ce(3+) atoms occupy the center of the oxygen vacancies surrounded by Ce(4+) atoms. Until now, CNPs have been associated with organic molecules at the synthesis stage to extend their applications or improve their stability. However, there is a lack of information regarding the post-synthesis interaction of CNPs and organic molecules that could enhance or induce new properties...
May 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28524762/exosomes-promote-restoration-after-an-experimental-animal-model-of-intracerebral-hemorrhage
#3
Laura Otero-Ortega, Mari Carmen Gómez de Frutos, Fernando Laso-García, Berta Rodríguez-Frutos, Esperanza Medina-Gutiérrez, Juan Antonio López, Jesús Vázquez, Exuperio Díez-Tejedor, María Gutiérrez-Fernández
Exosomes are gaining importance because they show great promise in therapeutic applications for several diseases. Particularly in stroke, exosomes derived from mesenchymal stem cell (MSC) therapy work as paracrine effectors responsible for promoting neurovascular remodeling and functional recovery. Adult male rats were subjected to intracerebral hemorrhage (ICH) by intrastriatal injection of collagenase type IV; 24 h after surgery, MSC-derived exosomes were administered through the tail vein. The rats were euthanized at 7 or 28 days after treatment...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28516881/exploring-the-remission-concept-in-rheumatoid-arthritis-with-patients-and-rheumatologists-time-for-a-new-approach
#4
Carlos Acebes, José Luis Andreu, Alejandro Balsa, Enrique Battle, Javier de Toro-Santos, Francisco García Llorente, María Victoria Hernández, Benjamín Fernández-Gutiérrez, Cristina Hidalgo-Calleja, Lucía Mayordomo, Esperanza Naredo, Francisco Javier Narváez, Ana M Ortiz, José Luis Pablos, Trinidad Pérez-Sandoval, Carlos Rodríguez-Lozano, Olga Sánchez-Pernaute, Jacqueline Usón, José B Negrón, Estibaliz Loza, Loreto Carmona, Susana Gómez Castro, María Montoro Alvarez
OBJECTIVES: To explore the remission concept in rheumatoid arthritis (RA) and to compare remission definitions and related concepts between rheumatologists and patients with the purpose of identifying similarities and disparities to comprehend the different perspectives of the disease. METHODS: This was a qualitative study of discourse and content analysis through focus groups, conducted from February to March 2016. Four focus groups were set up, each one with different interests: rheumatologists involved in basic research (BR), rheumatologists with high specialisation in imaging techniques (IR), clinical rheumatologists (CR), and patients (PA)...
May 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28513586/hundreds-of-dual-stage-antimalarial-molecules-discovered-by-a-functional-gametocyte-screen
#5
Celia Miguel-Blanco, Irene Molina, Ana I Bardera, Beatriz Díaz, Laura de Las Heras, Sonia Lozano, Carolina González, Janneth Rodrigues, Michael J Delves, Andrea Ruecker, Gonzalo Colmenarejo, Sara Viera, María S Martínez-Martínez, Esther Fernández, Jake Baum, Robert E Sinden, Esperanza Herreros
Plasmodium falciparum stage V gametocytes are responsible for parasite transmission, and drugs targeting this stage are needed to support malaria elimination. We here screen the Tres Cantos Antimalarial Set (TCAMS) using the previously developed P. falciparum female gametocyte activation assay (Pf FGAA), which assesses stage V female gametocyte viability and functionality using Pfs25 expression. We identify over 400 compounds with activities <2 μM, chemically classified into 57 clusters and 33 singletons...
May 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28511693/antagonistic-action-on-nmda-glun2b-mediated-currents-of-two-peptides-that-were-conantokin-g-structure-based-designed
#6
Edwin A Reyes-Guzman, Nohora Vega-Castro, Edgar A Reyes-Montaño, Esperanza Recio-Pinto
BACKGROUND: The GluN2B subunit of the N-methyl-D-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with various disorders such neuropathic pain and neuronal death following hypoxia. Thus there is an interest in identifying NMDAr antagonists that interact specifically with the GluN2B subunit. Recently based on structural analysis between the GluN2B subunit and conantokin-G, a toxin that interacts selectively with the GluN2B subunit, we designed various peptides that are predicted to act as NMDAr antagonists by interacting with the GluN2B subunit...
May 16, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28511227/tenosynovitis-evaluation-using-image-fusion-and-b-flow-a-pilot-study-on-new-imaging-techniques-in-rheumatoid-arthritis-patients
#7
Mads Ammitzbøll-Danielsen, Daniel Glinatsi, Søren Torp-Pedersen, Jacob M Møller, Esperanza Naredo, Mikkel Ostergaard, Lene Terslev
Aim The aim of this study was to compare the assessment of tenosynovitis by ultrasound (US) and magnetic resonance imaging (MRI) using the image fusion technique and to investigate whether US B-flow imaging (BFI) is an alternative to Doppler US when assessing tenosynovitis. Materials and Methods 15 patients with rheumatoid arthritis (RA) had US-verified tenosynovitis in the wrist/hand. An MRI was performed of the wrist/hand with subsequent repeated US and image fusion. Images were compared in three steps: 1...
May 16, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28509612/defining-the-phylogenetic-position-of-amanita-species-from-andean-colombia
#8
Natalia Vargas, Carlos José Pardo-de La Hoz, Giovanna Danies, Ana Esperanza Franco-Molano, Pedro Jiménez, Silvia Restrepo, Alejandro Grajales
Amanita is a worldwide-distributed fungal genus, with approximately 600 known species. Most species within the genus are ectomycorrhizal (ECM), with some saprotrophic representatives. In this study, we constructed the first comprehensive phylogeny including ECM species from Colombia collected in native Quercus humboldtii forests and in introduced Pinus patula plantations. We included 8 species (A. brunneolocularis, A. colombiana, A. flavoconia, A. fuligineodisca, A. muscaria, A. rubescens, A. sororcula, and A...
April 12, 2017: Mycologia
https://www.readbyqxmd.com/read/28493183/geochemical-characterization-of-fluoride-in-water-table-salt-active-sediment-rock-and-soil-samples-and-its-possible-relationship-with-the-prevalence-of-enamel-fluorosis-in-children-in-four-municipalities-of-the-department-of-huila-colombia
#9
Stefania Martignon, Mario Omar Opazo-Gutiérrez, Möritz Velásquez-Riaño, Iván Rodrigo Orjuela-Osorio, Viviana Avila, Esperanza Angeles Martinez-Mier, María Clara González-Carrera, Jaime Alberto Ruiz-Carrizosa, Blanca Cecilia Silva-Hermida
Fluoride is an element that affects teeth and bone formation in animals and humans. Though the use of systemic fluoride is an evidence-based caries preventive measure, excessive ingestion can impair tooth development, mainly the mineralization of tooth enamel, leading to a condition known as enamel fluorosis. In this study, we investigated the geochemical characterization of fluoride in water, table salt, active sediment, rock and soil samples in four endemic enamel fluorosis sentinel municipalities of the department of Huila, Colombia (Pitalito, Altamira, El Agrado and Rivera), and its possible relationship with the prevalence of enamel fluorosis in children...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28475624/the-functional-microbiome-of-arthropods
#10
Mauro Degli Esposti, Esperanza Martinez Romero
Many studies on the microbiome of animals have been reported but a comprehensive analysis is lacking. Here we present a meta-analysis on the microbiomes of arthropods and their terrestrial habitat, focusing on the functional profile of bacterial communities derived from metabolic traits that are essential for microbial life. We report a detailed analysis of probably the largest set of biochemically defined functional traits ever examined in microbiome studies. This work deals with the phylum proteobacteria, which is usually dominant in marine and terrestrial environments and covers all functions associated with microbiomes...
2017: PloS One
https://www.readbyqxmd.com/read/28467515/prevalence-of-non-influenza-respiratory-viruses-in-acute-respiratory-infection-cases-in-mexico
#11
Larissa Fernandes-Matano, Irma Eloísa Monroy-Muñoz, Javier Angeles-Martínez, Brenda Sarquiz-Martinez, Iliana Donají Palomec-Nava, Hector Daniel Pardavé-Alejandre, Andrea Santos Coy-Arechavaleta, Clara Esperanza Santacruz-Tinoco, Joaquín González-Ibarra, Cesar Raúl González-Bonilla, José Esteban Muñoz-Medina
BACKGROUND: Acute respiratory infections are the leading cause of morbidity and mortality worldwide. Although a viral aetiological agent is estimated to be involved in up to 80% of cases, the majority of these agents have never been specifically identified. Since 2009, diagnostic and surveillance efforts for influenza virus have been applied worldwide. However, insufficient epidemiological information is available for the many other respiratory viruses that can cause Acute respiratory infections...
2017: PloS One
https://www.readbyqxmd.com/read/28459647/effect-of-gymnema-sylvestre-administration-on-metabolic-syndrome-insulin-sensitivity-and-insulin-secretion
#12
Laura Y Zuñiga, Manuel González-Ortiz, Esperanza Martínez-Abundis
Gymnema sylvestre is a medicinal plant whose consumption has demonstrated benefits on lipid and glucose levels, blood pressure, and body weight (BWt). The aim of this study was to evaluate the effect of G. sylvestre administration on metabolic syndrome (MetS), insulin secretion, and insulin sensitivity. A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients (without pharmacological treatment), 30-60 years old, with diagnosis of MetS in accordance with the modified International Diabetes Federation criteria...
May 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28454629/study-of-fingerprints-in-argentina-population-for-application-in-personal-identification
#13
Noemí Rivaldería, Esperanza Gutiérrez-Redomero, Concepción Alonso-Rodríguez, José E Dipierri, Luis M Martín
The fingerprints of the Buenos Aires and Chubut provinces in Argentina have been studied, with the aim of knowing and quantifying the variability of these features, which are used in the identification process. The data studied for this research was obtained from 330 individuals, of both sexes, from two Argentinian population samples (170 individuals from Buenos Aires and 160 from Chubut), which amounts to a total of 3300 fingerprints. The different types of minutiae were located, identified, and visually quantified in four areas on the fingerprint...
May 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28452640/confirmatory-factor-analysis-for-the-multidimensional-scale-of-perceived-social-support-in-a-sample-of-early-retirees-enrolled-in-university-programs
#14
Yolanda López Ramos, Juan José Fernández Muñoz, Esperanza Navarro-Pardo, Mike Murphy
OBJECTIVE: The aims of this study were twofold-first, to use confirmatory factor analysis (CFA) to help assess which of the previously identified factor structures (identified through exploratory factor analysis) best fits a Spanish-language version of the Multidimensional Scale of Perceived Social Support (MSPSS), and second, to validate the MSPSS (and its subscales) for use among early retirees. METHODS: The psychometric properties of the MPSS were analyzed in a sample of 991 Spanish early retirees enrolled in university programs...
June 14, 2016: Clinical Gerontologist
https://www.readbyqxmd.com/read/28451802/clinical-characteristics-of-patients-with-central-nervous-system-relapse-in-bcr-abl1-positive-acute-lymphoblastic-leukemia-the-importance-of-characterizing-abl1-mutations-in-cerebrospinal-fluid
#15
Ricardo Sanchez, Rosa Ayala, Rafael Alberto Alonso, María Pilar Martínez, Jordi Ribera, Olga García, José Sanchez-Pina, Santiago Mercadal, Pau Montesinos, Rodrigo Martino, Pere Barba, José González-Campos, Manuel Barrios, Esperanza Lavilla, Cristina Gil, Teresa Bernal, Lourdes Escoda, Eugenia Abella, Ma Luz Amigo, Ma José Moreno, Pilar Bravo, Ramón Guàrdia, Jesús-María Hernández-Rivas, Antoni García-Guiñón, Sonia Piernas, José-María Ribera, Joaquín Martínez-López
We investigated the frequency, predictors, and evolution of acute lymphoblastic leukemia (ALL) in patients with CNS relapse and introduced a novel method for studying BCR-ABL1 protein variants in cDNA from bone marrow (BM) and cerebrospinal fluid (CSF) blast cells. A total of 128 patients were analyzed in two PETHEMA clinical trials. All achieved complete remission after imatinib treatment. Of these, 30 (23%) experienced a relapse after achieving complete remission, and 13 (10%) had an isolated CNS relapse or combined CNS and BM relapses...
April 27, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28449721/effectiveness-of-an-intervention-for-improving-drug-prescription-in-primary-care-patients-with-multimorbidity-and-polypharmacy-study-protocol-of-a-cluster-randomized-clinical-trial-multi-pap-project
#16
Alexandra Prados-Torres, Isabel Del Cura-González, Daniel Prados-Torres, Juan A López-Rodríguez, Francisca Leiva-Fernández, Amaia Calderón-Larrañaga, Fernando López-Verde, Luis A Gimeno-Feliu, Esperanza Escortell-Mayor, Victoria Pico-Soler, Teresa Sanz-Cuesta, Mª Josefa Bujalance-Zafra, Mariel Morey-Montalvo, José Ramón Boxó-Cifuentes, Beatriz Poblador-Plou, José Manuel Fernández-Arquero, Francisca González-Rubio, María D Ramiro-González, Carlos Coscollar-Santaliestra, Jesús Martín-Fernández, Mª Pilar Barnestein-Fonseca, José María Valderas-Martínez, Alessandra Marengoni, Christiane Muth
BACKGROUND: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management...
April 27, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28440758/abdominal-pain-and-hipertensive-crisis-as-initial-manifestation-of-a-malignant-pheocromocytoma
#17
Julia Campos-Fernández, Esperanza Aguillo-Gutiérrez, Ana Agudo-Tabuenca, Ana Lidia Medrano-Navarro, Laura Borau-Maorad
No abstract text is available yet for this article.
March 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28421802/capital-psicol%C3%A3-gico-y-su-relaci%C3%A3-n-con-el-estilo-de-vida-de-universitarios-mexicanos
#18
Joel Omar González-Cantero, Roberto Oropeza Tena, Ferran Padrós Blázquez, Cecilia Colunga Rodríguez, Roberto Montes Delgado, Víctor Hugo González-Becerra
Introducción: en algunos estudios se ha reportado que los universitarios no tienen un estilo de vida saludable (EVS) por lo que es necesario identificar no solo las variables psicosociales negativas, sino también las variables de Psicología Positiva que pueden favorecerlo.Objetivo: Determinar la relación entre el capital psicológico (CapPsi) y el estilo de vida (EV) de estudiantes universitarios mexicanos.Método: se realizó un estudio transversal y correlacional con 320 estudiantes de una universidad pública...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28421282/associations-between-a-mediterranean-diet-pattern-and-inflammatory-biomarkers-in-european-adolescents
#19
Aline Arouca, Nathalie Michels, Luis A Moreno, Esther M González-Gil, Ascensión Marcos, Sonia Gómez, Ligia Esperanza Díaz, Kurt Widhalm, Dénes Molnár, Yannis Manios, Frederic Gottrand, Antonio Kafatos, Mathilde Kersting, Michael Sjöström, Alejandro de la O, Marika Ferrari, Inge Huybrechts, Marcela Gonzalez-Gross, Stefaan De Henauw
AIM: To test whether the Mediterranean diet score and each food-subgroup is associated with inflammatory biomarkers in European adolescents. METHODS: In 464 adolescents (13-17 years) of the European HELENA study, data were available on body composition, inflammation markers, and food intake determined by two computerized 24-h recalls. The Mediterranean diet score and its food-subgroups (Vegetables, Fruits and Nuts, Pulses, Cereal and Roots, Monounsaturated/Saturated fat ratio, Dairy, Fish, Meat and Alcohol) were evaluated...
April 18, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28407524/age-at-surgery-as-a-predictor-of-cognitive-improvements-in-patients-with-drug-resistant-temporal-epilepsy
#20
Irene Cano-López, Juan Francisco Vázquez, Anabel Campos, Antonio Gutiérrez, Mercedes Garcés, Asier Gómez-Ibáñez, Rebeca Conde, Esperanza González-Bono, Vicente Villanueva
Temporal lobe epilepsy (TLE) surgery is an effective procedure that can produce cognitive changes. However, the prognostic factors related with cognitive outcomes need to be better understood. The aim of the present study is to know if age at surgery is a reliable predictor of verbal memory competence and considering factors such as: hemisphere; type of surgery; pre-surgical seizure frequency; and epilepsy duration. Sixty-one typically dominant patients with drug-resistant TLE (34 with left TLE [L-TLE] and 27 with right TLE [R-TLE]) underwent a neuropsychological assessment before and a year after surgery...
May 2017: Epilepsy & Behavior: E&B
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