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https://www.readbyqxmd.com/read/29224922/neurons-and-satellite-glial-cells-in-adult-rat-lumbar-dorsal-root-ganglia-express-connexin-36
#1
E Martha Pérez Armendariz, Monica Norcini, Beatriz Hernández-Tellez, Andrés Castell-Rodríguez, Cristina Coronel-Cruz, Raquel Guerrero Alquicira, Alexandra Sideris, Esperanza Recio-Pinto
Previous studies have shown that following peripheral nerve injury there was a downregulation of the gap junction protein connexin 36 (Cx36) in the spinal cord; however, it is not known whether Cx36 protein is expressed in the dorsal root ganglia (DRGs), nor if its levels are altered following peripheral nerve injuries. Here we address these aspects in the adult rat lumbar DRG. Cx36 mRNA was detected using qRT-PCR, and Cx36 protein was identified in DRG sections using immunohistochemistry (IHC) and immunofluorescence (IF)...
December 7, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29224179/antidiabetic-polypill-improves-central-pathology-and-cognitive-impairment-in-a-mixed-model-of-alzheimer-s-disease-and-type-2-diabetes
#2
Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Esperanza Ortegon, Eleanor Pickett, Rosemary Jackson, Fernando Hernandez-Pacho, Tara Spires-Jones, Monica Garcia-Alloza
Type 2 diabetes (T2D) is an important risk factor to suffer dementia, being Alzheimer's disease (AD) as the most common form. Both AD and T2D are closely related to aging and with a growing elderly population it might be of relevance to explore new therapeutic approaches that may slow or prevent central complications associated with metabolic disorders. Therefore, we propose the use of the antidiabetic polypill (PP), a pharmacological cocktail, commonly used by T2D patients that include metformin, aspirin, simvastatin, and an angiotensin-converting enzyme inhibitor...
December 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29222443/metabolic-versatility-of-small-archaea-micrarchaeota-and-parvarchaeota
#3
Lin-Xing Chen, Celia Méndez-García, Nina Dombrowski, Luis E Servín-Garcidueñas, Emiley A Eloe-Fadrosh, Bao-Zhu Fang, Zhen-Hao Luo, Sha Tan, Xiao-Yang Zhi, Zheng-Shuang Hua, Esperanza Martinez-Romero, Tanja Woyke, Li-Nan Huang, Jesús Sánchez, Ana Isabel Peláez, Manuel Ferrer, Brett J Baker, Wen-Sheng Shu
Small acidophilic archaea belonging to Micrarchaeota and Parvarchaeota phyla are known to physically interact with some Thermoplasmatales members in nature. However, due to a lack of cultivation and limited genomes on hand, their biodiversity, metabolisms, and physiologies remain largely unresolved. Here, we obtained 39 genomes from acid mine drainage (AMD) and hot spring environments around the world. 16S rRNA gene based analyses revealed that Parvarchaeota were only detected in AMD and hot spring habitats, while Micrarchaeota were also detected in others including soil, peat, hypersaline mat, and freshwater, suggesting a considerable higher diversity and broader than expected habitat distribution for this phylum...
December 8, 2017: ISME Journal
https://www.readbyqxmd.com/read/29222390/sodium-channel-remodeling-in-subcellular-microdomains-of-murine-failing-cardiomyocytes
#4
Mathilde R Rivaud, Esperanza Agullo-Pascual, Xianming Lin, Alejandra Leo-Macias, Mingliang Zhang, Eli Rothenberg, Connie R Bezzina, Mario Delmar, Carol Ann Remme
BACKGROUND: Cardiac sodium channel (NaV1.5) dysfunction contributes to arrhythmogenesis during pathophysiological conditions. Nav1.5 localizes to distinct subcellular microdomains within the cardiomyocyte, where it associates with region-specific proteins, yielding complexes whose function is location specific. We herein investigated sodium channel remodeling within distinct cardiomyocyte microdomains during heart failure. METHODS AND RESULTS: Mice were subjected to 6 weeks of transverse aortic constriction (TAC; n=32) to induce heart failure...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29206827/-health-obligation-or-health-fascism
#5
José Luis Sandoval-Gutiérrez
El Dr. Lifshitz presenta un editorial interesante sobre la campaña de una región de Italia que pretendía que la salud debía ser obligatoria y que quien no la obedeciera tendría pena de muerte. Esta pretensión, que de entrada resulta simpática, quizá muestra la desesperación de un sistema de salud que se ve rebasado presupuestalmente con el incremento de la esperanza de vida y, por ende, de la presentación de enfermedades crónicas degenerativas en la población.
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29190648/anterior-chamber-associated-immune-deviation-used-as-a-neuroprotective-strategy-in-rats-with-spinal-cord-injury
#6
Beatriz Pineda-Rodriguez, Diana Toscano-Tejeida, Elisa García-Vences, Roxana Rodriguez-Barrera, Adrian Flores-Romero, Daniela Castellanos-Canales, Gabriel Gutierrez-Ospina, Laura Castillo-Carvajal, Esperanza Meléndez-Herrera, Antonio Ibarra
The inflammatory response is probably one of the main destructive events occurring after spinal cord injury (SCI). Its progression depends mostly on the autoimmune response developed against neural constituents. Therefore, modulation or inhibition of this self-reactive reaction could help to reduce tissue destruction. Anterior chamber associated immune deviation (ACAID) is a phenomenon that induces immune-tolerance to antigens injected into the eye´s anterior chamber, provoking the reduction of such immune response...
2017: PloS One
https://www.readbyqxmd.com/read/29190557/prenatal-co-exposure-to-neurotoxic-metals-and-neurodevelopment-in-preschool-children-the-environment-and-childhood-inma-project
#7
Carmen Freire, Esperanza Amaya, Fernando Gil, Mariana F Fernández, Mario Murcia, Sabrina Llop, Ainara Andiarena, Juanjo Aurrekoetxea, Mariona Bustamante, Mònica Guxens, Esteban Ezama, Guillermo Fernández-Tardón, Nicolás Olea
We sought to determine whether prenatal co-exposure to As, Cd, Hg, Mn, and Pb was associated with impaired neurodevelopment in preschool children from the Spanish Environment and Childhood (INMA) Project, using the placenta as exposure matrix. We measured metal levels in placenta tissue samples randomly selected from five of the seven population-based birth cohorts participating in the INMA Project, collected between 2000 and 2008. Neuropsychological assessment of cognitive and motor function was carried through the use of the McCarthy Scales of Children's Abilities (MSCA) at the age of 4-5years...
November 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29186239/cutaneous-mucormycosis
#8
Ana Daniela Castrejón-Pérez, Esperanza C Welsh, Ivett Miranda, Jorge Ocampo-Candiani, Oliverio Welsh
Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29183649/a-happiness-degree-predictor-using-the-conceptual-data-structure-for-deep-learning-architectures
#9
Francisco Javier Pérez-Benito, Patricia Villacampa-Fernández, J Alberto Conejero, Juan M García-Gómez, Esperanza Navarro-Pardo
BACKGROUND AND OBJECTIVE: Happiness is a universal fundamental human goal. Since the emergence of Positive Psychology, a major focus in psychological research has been to study the role of certain factors in the prediction of happiness. The conventional methodologies are based on linear relationships, such as the commonly used Multivariate Linear Regression (MLR), which may suffer from the lack of representative capacity to the varied psychological features. Using Deep Neural Networks (DNN), we define a Happiness Degree Predictor (H-DP) based on the answers to five psychometric standardized questionnaires...
November 13, 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29166940/effects-of-urban-coarse-particles-inhalation-on-oxidative-and-inflammatory-parameters-in-the-mouse-lung-and-colon
#10
Cécile Vignal, Muriel Pichavant, Laurent Y Alleman, Madjid Djouina, Florian Dingreville, Esperanza Perdrix, Christophe Waxin, Adil Ouali Alami, Corinne Gower-Rousseau, Pierre Desreumaux, Mathilde Body-Malapel
BACKGROUND: Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection...
November 22, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29166310/universal-applicability-of-the-furlow-palatoplasty-resident-as-primary-surgeon-in-a-consecutive-nonselective-series
#11
Mitchell A Stotland, Thanapoom Boonipat, Cheryl M Lundgren, Esperanza Garcia Gonzalo
BACKGROUND: Questions persist regarding the general applicability of the Furlow palatoplasty technique, and thus, widespread adoption of its use has been uneven. This study describes a consecutive, nonselective series of primary Furlow palatoplasties. Highlighted is the unique fact that plastic surgical residents functioned as the primary surgeon for all steps of all procedures throughout the series. METHODS: A retrospective review was undertaken of all primary palatoplasties performed under the direction of the senior surgeon between December 2005 and April 2012...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29152910/treating-amblyopia-in-adults-with-prosthetic-occluding-contact-lenses
#12
Esperanza Garcia-Romo, Consuelo Perez-Rico, Isabel Roldán-Díaz, Juan Arévalo-Serrano, Román Blanco
PURPOSE: To investigate the feasibility, effectiveness and acceptability of using prosthetic occluding contact lenses (OCLs) to treat moderate amblyopia in adults and of the role of the multifocal visual evoked potential (mfVEP) as a predictor of postamblyopic therapy. METHODS: A comparative, prospective, interventional, case series pilot study with amblyopic adults (mean age: 40 years, range 20-50 years) allocated into two intervention groups: eye patching and OCL...
November 20, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29152125/cd49b-inhibits-osteogenic-differentiation-and-plays-an-important-role-in-osteosarcoma-progression
#13
Tingting Ren, Sajida Piperdi, Pratistha Koirala, Amy Park, Wendong Zhang, Daria Ivenitsky, Yidan Zhang, Esperanza Villanueva-Siles, Douglas S Hawkins, Michael Roth, Richard Gorlick
Osteosarcoma is a cancer whose cell of origin lies in the differentiation pathway between the mesenchymal stem cell (MSC) and the osteoblast (OB). In this study, we sought to determine if surface markers associated with osteoblastic differentiation are involved in osteosarcoma progression. cDNA expression arrays were performed on MSCs and osteoblasts to identify differentially expressed genes. The specificity of candidate genes for osteoblast differentiation was assessed through time course experiments in differentiation media with confirmation utilizing CD49b transfected MSCs...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146860/complete-genome-sequence-of-a-novel-nonnodulating-rhizobium-species-isolated-from-agave-americana-l-rhizosphere
#14
Víctor Manuel Ruíz-Valdiviezo, Marco Antonio Rogel-Hernandez, Gabriela Guerrero, Clara Ivette Rincón-Molina, Luis Galdino García-Perez, Federico Antonio Gutiérrez-Miceli, Juan José Villalobos-Maldonado, Aline López-López, Esperanza Martinez-Romero, Reiner Rincón-Rosales
We report here the complete genome sequence of Rhizobium sp. strain ACO-34A, isolated from Agave americana L. rhizosphere. No common nod genes were found, but there were nif genes for nitrogen fixing. A low average nucleotide identity to reported species supports its designation as a novel Rhizobium species that has a complete ribosomal operon in a plasmid.
November 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29138096/one-single-salt-bridge-explains-the-different-cytolytic-activities-shown-by-actinoporins-sticholysin-i-and-ii-from-the-venom-of-stichodactyla-helianthus
#15
Esperanza Rivera-de-Torre, Juan Palacios-Ortega, Sara García-Linares, José G Gavilanes, Álvaro Martínez-Del-Pozo
Sticholysins I and II (StnI and StnII), α-pore forming toxins from the sea anemone Stichodactyla helianthus, are water-soluble toxic proteins which upon interaction with lipid membranes of specific composition bind to the bilayer, extend and insert their N-terminal α-helix, and become oligomeric integral membrane structures. The result is a pore that leads to cell death by osmotic shock. StnI and StnII show 93% of sequence identity, but also different membrane pore-forming activities. The hydrophobicity profile along the first 18 residues revealed differences which were canceled by substituting StnI amino acids 2 and 9...
November 11, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29135090/gene-expression-profiling-demonstrates-wnt-%C3%AE-catenin-pathway-genes-alteration-in-mexican-patients-with-colorectal-cancer-and-diabetes-mellitus
#16
Laura Ivonne Wence-Chavez, Ulises Palomares-Chacon, Juan Pablo Flores-Gutierrez, Luis Felipe Jave-Suarez, Adriana Del Carmen Aguilar-Lemarroy, Patricio Barros-Nunez, Silvia Esperanza Flores-Martinez, Jose Sanchez-Corona, Monica Alejandra Rosales-Reynoso
PURPOSE: Several studies have shown a strong association between diabetes mellitus (DM) and increased risk of colorectal cancer (CRC). The fundamental mechanisms that support this association are not entirely understood; however, it is believed that hyperinsulinemia and hyperglycemia may be involved. Some proposed mechanisms include upregulation of mitogenic signaling pathways like MAPK, PI3K, mTOR, and WNT, which are involved in cell proliferation, growth, and cancer cell survival. The purpose of this study was to evaluate the gene expression profile and identify differently expressed genes involved in mitogenic pathways in CRC patients with and without DM...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29130699/inflammation-and-insulin-resistance-according-to-body-composition-in-european-adolescents-the-helena-study
#17
Esther González-Gil, Luis Gracia-Marco, Javier Santabárbara, Denes Molnar, Francisco Jose Amaro Gahete, Frederic Gottrand, Aline Arouca, Antonios Kafatos, Kurt Widhalm, Yannis Manios, Alfonso Siani, Marcela González-Gross, Sonia Gómez-Martínez, Ligia Esperanza Díaz, Catherine Leclerq, Jean Dallongeville, Ascensión Marcos, Luis A Moreno Aznar
INTRODUCTION: Inflammation is related to insulin resistance in adults, especially on those individuals with high levels of body composition. OBJECTIVES: The aim of this study is to assess the relationship between a set of inflammatory biomarkers and insulin resistance by levels of body composition in a sample of European adolescents. MATERIAL AND METHODS: Nine hundred and sixty-two adolescents (442 boys and 520 girls) from nine European countries met the inclusion criteria of having measurements for the homeostasis model assessment (HOMA) and a set of inflammation-related biomarkers: C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors C3 and C4 and selected cell adhesion molecules...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29124680/the-antiepileptic-drug-levetiracetam-protects-against-quinolinic-acid-induced-toxicity-in-the-rat-striatum
#18
Maricela Dircio-Bautista, Ana Laura Colín-González, Gabriela Aguilera, Marisol Maya-López, Juana Villeda-Hernández, Sonia Galván-Arzate, Esperanza García, Isaac Túnez, Abel Santamaría
Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release. The tryptophan metabolite quinolinic acid (QUIN) acts as an excitotoxin when its brain concentrations reach toxic levels under pathological conditions. Since increased neuronal excitability induced by QUIN recruits degenerative events in the brain, and novel AED is also expected to exert neuroprotective effects in their pharmacological profiles, in this work the effect of LVT (54 mg/kg, i...
November 9, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29122317/sonographic-and-anatomic-description-of-the-subtalar-joint
#19
Peter Mandl, David Bong, Peter V Balint, Hilde Berner Hammer, Maribel Miguel, Esperanza Naredo, Lene Terslev, Ingrid Möller
Our study provides a detailed anatomic and sonographic description of the subtalar joint, a single joint that, anatomically, is divided into the anterior subtalar joint (ASTJ) and the posterior subtalar joint (PSTJ). Cadaver specimens of the ankle and foot were examined in detail by ultrasound (US), and the subtalar joints of all the specimens were injected with colored latex of a contrasting color under US guidance. Compatible with other studies, examination of the sections revealed lack of communication between the ASTJ and the PSTJ and communication between the PSTJ and the posterior recess of the tibiotalar joint...
November 6, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29120306/migration-and-social-determinants-of-mental-health-results-from-the-canadian-health-measures-survey
#20
Bukola Salami, Maryna Yaskina, Kathleen Hegadoren, Esperanza Diaz, Salima Meherali, Anu Rammohan, Yoav Ben-Shlomo
OBJECTIVES: Studies worldwide point to increased risk of mental health problems among immigrants. However, the data on Canadian immigrants' mental health are ambiguous. To address this, we examined the relationship of both self-perceived mental health and reported diagnosis of mood disorders with age, gender, migration status, time since migration, and social determinants of health factors. METHODS: We analyzed three cycles of the Canadian Health Measures Survey...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
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