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Georgina Avalos-Durán, Ana María Emilia Cañedo-Del Ángel, Juana Rivero-Murillo, Jaime Enoc Zambrano-Guerrero, Esperanza Carballo-Mondragón, Miguel Ángel Checa-Vizcaíno
OBJECTIVES: To determine the efficacy of the physiological ICSI technique (PICSI) vs. conventional ICSI in the prognosis of couples, with respect to the following outcome measures: live births, clinical pregnancy, implantation, embryo quality, fertilization and miscarriage rates. METHODS: A systematic review of the literature, extracting raw data and performing data analysis. Patient(s): Couples with the male factor, who were subjected to in-vitro fertilization...
April 19, 2018: JBRA Assisted Reproduction
Vivian N Mbanya, Abdi A Gele, Esperanza Diaz, Bernadette Kumar
BACKGROUND: Female genital mutilation/cutting (FGM/C) is a great concern, considering all the potential health implications. Use of health care services related to FGM/C by women who have been subjected to FGM/C in Norway remains to be understood. This study aims to explore the health care-seeking patterns for FGM/C-related health care problems, among young Somalis in Norway. METHODS: A cross-sectional study involving 325 young Somalis in Oslo was conducted in 2014 using respondent-driven sampling (RDS) technique...
April 18, 2018: BMC Public Health
Jacobo Galán, Isaac Martin, Itziar Carmona, José María Rodriguez-Barbero, Esperanza Cuadrado, Luis García-Alonso, José Antonio García-Vela
Primary effusion lymphoma (PEL) is a rare B cell lymphoproliferative disorder that arises predominantly in body cavities causing malignant effusions.The incidence of PEL is very low, accounting for approximately 4% of all HIV-associated non-Hodgkin lymphomas. PEL has also been described in elderly patients and after solid-organ transplantation. It is associated in all cases with human herpesvirus 8 (HHV8). We describe a case of PEL in a 88-year-old HIV-negative woman who presented with progressive dyspnea and moderate right-sided pleural effusion without significate lymphadenopathies or other effusions...
April 18, 2018: Cytometry. Part B, Clinical Cytometry
Astri Syse, Minja T Dzamarija, Bernadette N Kumar, Esperanza Diaz
BACKGROUND: Knowledge of mortality differentials in immigrant groups depending on their reason for migration, length of stay in host countries and characteristics of sending countries may be beneficial for policy interventions aimed to improve various immigrant groups' health and welfare. METHODS: We employed discrete-time hazard regression models with time-varying covariates to compare the death risk of immigrants to those of Norwegian-born natives using linked register data on the Norwegian population aged 25-79 during 1990-2015...
April 17, 2018: BMC Public Health
Esperanza Doña, Casilda Olveira, Francisco Javier Palenque, Nuria Porras, Antonio Dorado, Rocío Martín-Valero, Ana M Godoy, Francisco Espíldora, Victoria Contreras, Gabriel Olveira
BACKGROUND: In individuals with bronchiectasis, fat-free mass depletion may be common despite a low prevalence of underweight and is considered a risk factor for increased morbidity and mortality. Techniques to adequately estimate fat-free mass and its changes over time are needed. OBJECTIVE: The purpose of this study was to assess agreement among values obtained with three different body composition techniques: skinfold thickness measurement (STM), bioelectrical impedance analysis (BIA), and dual-energy x-ray absorptiometry (DXA)...
April 12, 2018: Journal of the Academy of Nutrition and Dietetics
Carmen Martínez-Losada, Juana Serrano-López, Josefina Serrano-López, Nelida I Noguera, Eduardo Garza, Liliana Piredda, Serena Lavorgna, María Antonietta Irno Consalvo, Tiziana Ottone, Valentina Alfonso, Juan Ramón Peinado, María Victoria Garcia-Ortiz, Teresa Morales-Ruiz, Andrés Jérez, Ana María Hurtado, Pau Montesinos, José Cervera, Esperanza Such, Marian Ibañez, Amparo Sempere, Miguel Ángel Sanz, Francesco Lo Coco, Joaquín Sánchez-García
No abstract text is available yet for this article.
April 5, 2018: Haematologica
Frederic D L Leusch, Peta A Neale, Charlotte Arnal, Natalie H Aneck-Hahn, Patrick Balaguer, Auguste Bruchet, Beate I Escher, Mar Esperanza, Marina Grimaldi, Gaela Leroy, Marco Scheurer, Rita Schlichting, Merijn Schriks, Armelle Hebert
The aquatic environment can contain numerous micropollutants and there are concerns about endocrine activity in environmental waters and the potential impacts on human and ecosystem health. In this study a complementary chemical analysis and in vitro bioassay approach was applied to evaluate endocrine activity in treated wastewater, surface water and drinking water samples from six countries (Germany, Australia, France, South Africa, the Netherlands and Spain). The bioassay test battery included assays indicative of seven endocrine pathways, while 58 different chemicals, including pesticides, pharmaceuticals and industrial compounds, were analysed by targeted chemical analysis...
March 27, 2018: Water Research
Ismael San Mauro Martín, Javier Andrés Blumenfeld Olivares, Eva Pérez Arruche, Esperanza Arce Delgado, María José Ciudad Cabañas, Elena Garicano Vilar, Luis Collado Yurrita
Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women)...
April 3, 2018: Diseases (Basel)
María Díez-Campelo, Jose I Lorenzo, Raphael Itzykson, Silvia M Rojas, Céline Berthon, Elisa Luño, Odile Beyne-Rauzy, Jaime Perez-Oteyza, Norbert Vey, Joan Bargay, Sophie Park, Teresa Cedena, Dominique Bordessoule, Juan A Muñoz, Emmanuel Gyan, Esperanza Such, Sorin Visanica, Félix López-Cadenas, Stéphane de Botton, Jesús M Hernández-Rivas, Shanti Ame, Aspasia Stamatoullas, Jacques Delaunay, Celia Salanoubat, Françoise Isnard, Romain Guieze, Joan Pérez Guallar, Llorenc Badiella, Guillermo Sanz, Consuelo Cañizo, Pierre Fenaux
Treatment with azacitidine (AZA) has been suggested to be of benefit for higher-risk myelodysplastic syndrome (HR-MDS) patients with chromosome 7 abnormalities (Abn 7). This retrospective study of 235 HR-MDS patients with Abn 7 treated with AZA (n = 115) versus best supportive care (BSC; n = 120), assessed AZA treatment as a time-varying variable in multivariable analysis. A Cox Regression model with time-interaction terms of overall survival (OS) at different time points confirmed that, while chromosome 7 cytogenetic categories (complex karyotype [CK] versus non-CK) and International Prognostic Scoring System risk (high versus intermediate-2) retained poor prognosis over time, AZA treatment had a favourable impact on OS during the first 3 years of treatment compared to BSC (Hazard ratio [HR] 0·5 P < 0·001 at 1 year, 0·7 P = 0·019 at 2 years; 0·73 P = 0·029 at 3 years)...
April 2, 2018: British Journal of Haematology
Diana Montes-Grajales, Esperanza Martínez-Romero, Jesus Olivero-Verbel
Breast cancer is a highly heterogeneous disease influenced by the hormonal microenvironment and the most common malignancy in women worldwide. Some phytoestrogens and mycoestrogens have been epidemiologically linked as risk factors or protectors, however their mechanisms of action are complex and not fully understood. The aim of this study was to predict the potential of 36 natural xenoestrogens to interact with 189 breast cancer proteins using AutoDock Vina. In order to validate our protocol, an in silico docking pose and binding site determination was compared with the crystallographic structure and the power of prediction to distinguish between ligand and decoys was evaluated though a receiver operating characteristic curve (ROC) of the resultant docking affinities and in vitro data...
March 30, 2018: Steroids
José Luis Martín-Varillas, Vanesa Calvo-Río, Emma Beltrán, Juan Sánchez-Bursón, Marina Mesquida, Alfredo Adán, María Victoria Hernandez, Marisa Hernández Garfella, Elia Valls Pascual, Lucía Martínez-Costa, Agustí Sellas-Fernández, Miguel Cordero-Coma, Manuel Díaz-Llopis, Roberto Gallego, David Salom, Norberto Ortego, José L García-Serrano, José-Luis Callejas-Rubio, José M Herreras, Ángel García-Aparicio, Olga Maíz, Ana Blanco, Ignacio Torre, David Díaz-Valle, Esperanza Pato, Elena Aurrecoechea, Miguel A Caracuel, Fernando Gamero, Enrique Minguez, Carmen Carrasco-Cubero, Alejandro Olive, Julio Vázquez, Oscar Ruiz-Moreno, Javier Manero, Santiago Muñoz-Fernández, Myriam Gandía Martinez, Esteban Rubio-Romero, F Javier Toyos-Sáenz de Miera, Francisco Javier López Longo, Joan M Nolla, Marcelino Revenga, Carmen González-Vela, Javier Loricera, Belén Atienza-Mateo, Rosalía Demetrio-Pablo, José Luis Hernández, Miguel A González-Gay, Ricardo Blanco
PURPOSE: To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN: Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants. SUBJECTS: Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months...
March 27, 2018: Ophthalmology
Nicolás Merchante, Francisco Rodríguez-Arrondo, Boris Revollo, Esperanza Merino, Sofía Ibarra, María J Galindo, Marta Montero, Miguel García-Deltoro, Antonio Rivero-Juárez, Francisco Téllez, Marcial Delgado-Fernández, María J Ríos-Villegas, María A García, Francisco J Vera-Méndez, Guillermo Ojeda-Burgos, Miguel A López-Ruz, Luis Metola, Mohamed Omar, María Remedios Alemán-Valls, Koldo Aguirrebengoa, Joseba Portu, Miguel Raffo, Juan Macías, Juan A Pineda
OBJECTIVE: To assess the possible association between the use of direct antiviral agents (DAA) and the risk of hepatocellular carcinoma (HCC) in HIV/HCV-coinfected patients. METHODS: The GEHEP-002 cohort recruits HCC cases in HIV-infected patients from 32 centers from Spain. Three analyses were performed: the proportion of HCC cases after sustained virological response (SVR) and the evolution of this proportion over time, the frequency of HCC after SVR in HIV/HCV-coinfected patients with cirrhosis, and the probability of HCC recurrence after curative therapies among those undergoing HCV therapy...
March 28, 2018: AIDS
Jose Maria Bueno, Felix Calderon, Jesús Chicharro, Juan Carlos de la Rosa, Beatriz Diaz, Jorge Fernandez, Jose M Fiandor, María Teresa Fraile, Mercedes Garcia, Esperanza Herreros, Adolfo García-Pérez, Milagros Lorenzo, Araceli Mallo, Margarita Puente, Anas Saadeddin, Santiago Ferrer, Iñigo Angulo-Barturen, Jeremy N Burrows, María Luisa Leon
Malaria is still one of the most prevalent parasitic infection in the world with half of the world's population at risk of malaria. The effectiveness of current antimalarial therapy is under continuous threat through the spread of resistant Plasmodium strains, even to the most recent class of antimalarial drugs (ACT: artemisinin-combination-therapies). As a consequence, there is still an urgent requirement for new antimalarial drugs. We previously reported the identification of 4(1H)-pyridones as a novel series with potent antimalarial activity...
March 28, 2018: Journal of Medicinal Chemistry
Sascha Ra Alles, Esperanza Garcia, Sridhar Balasubramanyan, Karen Jones, John R Tyson, Twinkle Joy, Terrance P Snutch, Peter A Smith
Background Following peripheral nerve chronic constriction injury, the accumulation of the α2δ-1 auxiliary subunit of voltage-gated Ca2+ channels in primary afferent terminals contributes to the onset of neuropathic pain. Overexpression of α2δ-1 in Xenopus oocytes increases the opening properties of Cav 1.2 L-type channels and allows Ca2+ influx at physiological membrane potentials. We therefore posited that L-type channels play a role in neurotransmitter release in the superficial dorsal horn in the chronic constriction injury model of neuropathic pain...
January 2018: Molecular Pain
Virginia Esperanza Fernández-Ruiz, José Antonio Paniagua-Urbano, María Solé-Agustí, Alfonso Ruiz-Sánchez, José Gómez-Marín, David Armero-Barranco
OBJECTIVE: Obesity is an entity of highly prevalent multifactorial origin with associated metabolic and psychological comorbidity, causing a negative impact on the quality of life of those who suffer from it. The objective is to evaluate the impact of an interdisciplinary program for nurse-led obesity on quality of life related to health and anxiety. METHODS: Randomized controlled clinical trial with a sample of 74 subjects diagnosed with obesity (EG: n=37; CG: n=37)...
April 2018: Archives of Psychiatric Nursing
Victoria Martínez-Sernández, María J Perteguer, Ana Hernández-González, Mercedes Mezo, Marta González-Warleta, Ricardo A Orbegozo-Medina, Fernanda Romarís, Esperanza Paniagua, Teresa Gárate, Florencio M Ubeira
Infections caused by Fasciola hepatica are of great importance in the veterinary field, as they cause important economic losses to livestock producers. Serodiagnostic methods, typically ELISA (with either native or recombinant antigens), are often used for early diagnosis. The use of native antigens, as in the MM3-SERO ELISA (commercialized as BIO K 211, BIO-X Diagnostics), continues to be beneficial in terms of sensitivity and specificity; however, there is interest in developing ELISA tests based on recombinant antigens to avoid the need to culture parasites...
March 21, 2018: Parasitology Research
Ana Quintáns-Fondo, Vanesa Santás-Miguel, Juan C Nóvoa-Muñoz, Manuel Arias-Estévez, María J Fernández-Sanjurjo, Esperanza Álvarez-Rodríguez, Avelino Núñez-Delgado
The purpose of this work was to elucidate the repercussion of changing pH, incubation time and As(V) competition on fluoride (F- ) sorption on forest and vineyard soil samples, pyritic, and granitic materials, as well as on the by-products pine sawdust, oak wood ash, mussel shell ash, fine and coarse mussel shell, and slate processing waste fines. To reach this end, the methodological approach was based on batch-type experiments. The results indicate that, for most materials, F- sorption was very high at the start, but was clearly diminished when the pH value increased...
2018: Frontiers in Chemistry
Francisco Javier Navas González, Jordi Jordana Vidal, María Esperanza Camacho Vallejo, Jose Manuel León Jurado, Manuel Rafael de la Haba Giraldo, Cecilio Barba Capote, Juan Vicente Delgado Bermejo
Cutaneous habronematidosis (CH) is a highly prevalent seasonally recurrent skin disease that affects donkeys as a result from the action of spirurid stomach worm larvae. Carrier flies mistakenly deposit these larvae on previous skin lesions or on the moisture of natural orifices, causing distress and inflicting relapsing wounds to the animals. First, we carried out a meta-analysis of the predisposing factors that could condition the development of CH in Andalusian donkeys. Second, basing on the empirical existence of an inter and intrafamilial variation previously addressed by owners, we isolated the genetic background behind the hypersensibility to this parasitological disease...
March 15, 2018: Veterinary Parasitology
Christine T Dinh, Olena Bracho, Christine Mei, Esperanza Bas, Cristina Fernandez-Valle, Fred Telischi, Xue-Zhong Liu
HYPOTHESIS: Microsurgical implantation of mouse merlin-deficient Schwann cells (MD-SC) into the cerebellopontine angle of immunodeficient rats will initiate tumor formation, hearing loss, and vestibular dysfunction. BACKGROUND: The progress in identifying effective drug therapies for treatment of Neurofibromatosis type II (NF2) is limited by the availability of animal models of VS that develop hearing loss and imbalance. METHODS: A microsurgical technique for implanting MD-SCs onto the cochleovestibular nerve of rats was developed...
March 19, 2018: Otology & Neurotology
Karl Landsteiner, Esperanza Lopez, Guillermo Milans Del Bosch
In the presence of a gravitational contribution to the chiral anomaly, the chiral magnetic effect induces an energy current proportional to the square of the temperature in equilibrium. In holography the thermal state corresponds to a black hole. We numerically study holographic quenches in which a planar shell of scalar matter falls into a black hole and raises its temperature. During the process the momentum density (energy current) is conserved. The energy current has two components, a nondissipative one induced by the anomaly and a dissipative flow component...
February 16, 2018: Physical Review Letters
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