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Blood culture negative endocarditis

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https://www.readbyqxmd.com/read/29903680/-non-infective-endocarditis
#1
A Le Bot, P Jégo, E Donal, E Flécher, M Revest, P Tattevin
Non-infective endocarditis, also referred to as non-bacterial thrombotic endocarditis, represent a wide range of rare pathologies, often severe. This review gathered the data available in the literature, to decipher the major information collected on the pathophysiology, the diagnosis and the treatment of these heterogeneous diseases, often misdiagnosed. Characteristics of non-infective endocarditis are similar to infective endocarditis in terms of valvular lesions (mostly left-sided, with regurgitations and vegetations), and their complications (embolism)...
June 11, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29895627/sub-acute-leaflet-thrombosis-a-reversible-cause-of-aortic-stenosis
#2
Athina Chasapi, Adam Hobbs, Theodore Velissaris, Benoy N Shah
A 77 year old male underwent elective bioprosthetic aortic valve replacement (23mm Carpentier-Edwards Perimount MagnaEase) for severe aortic stenosis. His pre-discharge transthoracic echocardiogram (TTE) was normal. He presented 9 days after surgery with dyspnoea and fever. He was in sinus rhythm. Blood cultures were taken and he was commenced on empirical antibiotics for possible infective endocarditis (subsequently all negative). Repeat TTE showed a well-seated prosthesis without regurgitation but elevated gradients (peak / mean gradients 49 / 22 mmHg respectively)...
June 12, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29886217/contemporary-results-of-surgical-management-of-peripheral-mycotic-aneurysms
#3
Gg Salzler, B Long, Ed Avgerinos, Ra Chaer, S Leers, E Hager, Ms Makaroun, Mh Eslami
OBJECTIVE: Mycotic aneurysms of the extremities occur infrequently but can cause severe life and limb complications. Traditional treatment typically includes debridement and revascularization, though in select patients ligation may be well tolerated. We reviewed our experience with these aneurysms treated with these two modalities. METHODS: A retrospective review of patients treated for peripheral mycotic aneurysms at one institution from January 2005 to December 2015 was performed under an Institutional Review Board-approved protocol...
June 7, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29866682/antiphospholipid-syndrome-masquerading-as-a-case-of-infective-endocarditis
#4
Sarah Micallef, Charles Mallia Azzopardi
A 54-year-old Caucasian woman presented with an episode of loss of consciousness and dysphasia. MRI revealed a number of ischaemic foci indicating an embolic source. Echocardiography showed a mitral valve vegetation. After taking three sets of blood cultures, she was started on empirical treatment for infective endocarditis. The blood cultures remained negative and a presumed diagnosis of culture-negative endocarditis was entertained. However, despite the antibiotic therapy, the patient deteriorated further...
June 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29807750/polymerase-chain-reaction-detection-of-bartonella-spp-in-dogs-from-spain-with-blood-culture-negative-infectious-endocarditis
#5
X Roura, G Santamarina, M-D Tabar, O Francino, L Altet
OBJECTIVES: The presence of Bartonella spp. was detected by polymerase chain reaction (PCR) in dogs from Spain with blood culture-negative endocarditis. The aim of this study is to add information about canine infectious endocarditis in Europe. ANIMALS: Thirty dogs with naturally occurring blood culture-negative endocarditis were examined from 2010 to 2017 at three veterinary referral hospitals, located in northwest, northeast, and southeast of Spain. METHODS: It is a retrospective study...
May 25, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29806608/-bartonella-henselae-infection-in-diverse-clinical-conditions-in-a-tertiary-care-hospital-in-north-india
#6
Rama Chaudhry, Prathyusha Kokkayil, Arnab Ghosh, Tej Bahadur, Kamala Kant, Tanu Sagar, Sunil Kumar Kabra, Rakesh Lodha, Aparajit Ballav Dey, Vimala Menon
Background & objectives: : Bartonella henselae causes infections which closely resemble febrile illness and chronic diseases such as tuberculosis and haematological malignancies. There are not many studies on Bartonella infections from India. The present study was undertaken to diagnose B. henselae infection in diverse clinical conditions in a tertiary care hospital in north India. Methods: A total of 145 patients including those with fever and lymphadenopathy, infective endocarditis and neuroretinitis were enrolled in the study...
February 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29765783/multiorgan-failure-and-refractory-lactic-acidosis-due-to-pasteurella-multocida-septicemia-in-a-patient-with-no-animal-exposure
#7
Damaris Pena, Yaneidy Santana, Jose Perez Lara, Efrain Gonzalez, Misbahuddin Khaja
Introduction: Pasteurella multocida is a gram-negative coccobacillus pathogenic to animals. It can cause infection in humans by a bite, scratch, or lick from a cat or dog. P. multocida can cause a variety of infections in humans, including cellulitis, osteomyelitis, endocarditis, peritonitis, and septic shock. Case Presentation: A 56-year-old male presented to our hospital with a 2-day history of fever, abdominal pain, nausea, and vomiting. He denied exposure to cats, dogs or other pets...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29755630/echocardiographic-features-in-bartonella-endocarditis-a-case-series
#8
Orathai Pachirat, Sompop Prathanee, George Watt
Bartonella spp. are emerging pathogens that are reported as the cause of blood culture-negative endocarditis ( BCNE). However, echocardiographic features and assessment of this endocarditis remains unclear. Four patients with B. henselae endocarditis were identified. All patients had underlying cardiac conditions: rheumatic heart disease in three, congenital heart disease in one. Evidence of vegetations was found on the aortic valve in all patients with large, highly mobile vegetations and severely destroyed valves demonstrated by the transthoracic echocardiogram leading to severe aortic regurgitation and heart failure...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29755627/molecular-diagnosis-of-bacterial-definite-infective-endocarditis-by-real-time-polymerase-chain-reaction
#9
Reza Faraji, Mostafa Behjati-Ardakani, Nooshin Faraji, Seyed Mohammad Moshtaghioun, Seyed Mehdi Kalantar, Ali Pedarzadeh, Hengameh Zandi, Mohammadtaghi Sarebanhassanabadi, Nastaran Ahmadi, Ali Dehghani Firoozabadi
Infective endocarditis (IE) can be diagnosed using the Duke criteria, which cannot be conclusive especially when the results of blood cultures are negative. This study aimed at using real-time polymerase chain reaction (PCR) technique to isolate bacteria present in whole blood samples of patients with definitive IE on the basis of the method designed in this study. This laboratory and test study was conducted on 20 whole blood samples taken from patients with definitive IE. Real-time PCR of the 16s rRNA was utilized to directly analyze whole blood samples to diagnose bacterial IE...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29705358/abdominal-pain-of-cardiovascular-origin
#10
Pedro Epifânio, Maria Emanuel Amaral, Natália Noronha, Paula Martins, Dina Rodrigues, António Pires, Eduardo Castela
Infective endocarditis is a microbial infection of the endocardium and it is rare in the pediatric population. In children, congenital heart disease is one of the most important risk factors for developing infective endocarditis and can involve other structures in addition to cardiac valves. The prognosis is generally better than in other forms of endocarditis, although the average mortality rate in the pediatric population is 15-25%. Clinical manifestations can mimic other diseases such as meningitis and collagen-vascular disease or vasculitis...
May 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29694648/prosthetic-valve-endocarditis-clinical-bacteriological-and-therapeutic-aspects
#11
Meriem Drissa, Sana Helali, Marwa Chebbi, Khaled Ezzaouia, Fadwa Omri, Habiba Drissa
BACKGROUND: The prosthetic valve endocarditis(PVE) is a serious complication of valve replacement surgery. The aim of this work was to analyze the clinical and echocardiography characters of the PVE, deduce surgery indication, and determinate the prognostic factors Methods :We presented a retrospective descriptive study from 2000 to 2014 which included 30 patients hospitalized in department of cardiology in la Rabta hospital for certain PVE according to DUCKES criteria. RESULTS: Our study consisted of 18 male patients with sex ratio of 1...
July 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29686571/-bartonella-endocarditis-with-glomerulonephritis-in-a-patient-with-complete-transposition-of-the-great-arteries
#12
Helen Hashemi, Tiana R Endicott-Yazdani, Christopher Oguayo, David M Harmon, Tuan Tran, Ginger Tsai-Nguyen, Raul Benavides, Cedric W Spak, Hoang-Lan Nguyen
We describe a patient with history of dextro-transposition of the great vessels, ventricular septal defect, and pulmonary valve replacement who presented with fatigue, prolonged fever, and leg edema. He was found to have kidney injury, pancytopenia, and liver congestion. Echocardiogram revealed thickened leaflets with prolapsing vegetation on the pulmonary valve. Given the negative blood cultures, high Bartonella henselae immunogobulin G titer (≥1:1024) and positive immunoglobulin M titer (≥1:20), he was diagnosed with Bartonella endocarditis complicated with glomerulonephritis...
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29619327/-brucella-vertebral-osteomyelitis-misidentified-as-an-ochrobactrum-anthropi-infection
#13
João Trêpa, Patricia Mendes, Raquel Gonçalves, Catarina Chaves, Ana Maria Brás, Andrea Mesa, Isabel Ramos, Rosa Sá, José Gabriel Saraiva da Cunha
Ochrobactrum anthropi is a Gram-negative bacillus widely distributed in nature. It is a low virulence and low pathogenic microorganism and human infection by this agent is considered rare. This microorganism can cause bacteremia and in some cases can lead to osteomyelitis and endocarditis. Included in Brucellaceae family, this bacterium is phenotypically and genetically closely related to the Brucella genus and may be misidentified by rapid identification systems. The authors describe a patient admitted to the Infectious Diseases Department with vertebral osteomyelitis initially identified as Ochrobactrum anthropi ...
2018: IDCases
https://www.readbyqxmd.com/read/29605416/lyme-endocarditis
#14
Ana C Paim, Larry M Baddour, Bobbi S Pritt, Audrey N Schuetz, John W Wilson
BACKGROUND: Valvular involvement as a manifestation of Lyme carditis is rare. The first case describing a possible association between Lyme disease and cardiac valvular disease in the United States was published in 1993. Since that time there have been 2 cases of Lyme endocarditis confirmed by Borrelia-positive 16S ribosomal RNA polymerase chain reaction and sequencing from valvular tissue and reported from Europe. Here we describe a case of Lyme endocarditis that, to our knowledge, is the first reported case confirmed by molecular diagnostics in the United States...
March 29, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29592983/rare-cause-of-fever-of-unknown-origin-gastrointestinal-stromal-tumour
#15
Manjunath Havalappa Dodamani, Rajiv Ranjan Kumar, Mayur Parkhi, Rajendar Basher
A 44-year-old man presented with fever (low to high grade) for 2-month duration despite treatment with oral antibiotics and antipyretics. Further, enquiry did not yield any potentially explanatory clues to a diagnosis. Physical examination revealed only left axillary lymphadenopathy, but was otherwise unremarkable. A number of diagnosis included tuberculosis, malignancy, lymphoma, connective disease disorder and infective endocarditis. Further evaluation revealed severe anaemia due to iron deficiency which was supported with blood transfusion and oral iron supplementation...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29563819/a-case-of-brucella-melitensis-endocarditis-in-a-patient-with-cardiovascular-implantable-electronic-device
#16
Wasl Al-Adsani, Ali Ahmad, Mohammad Al-Mousa
Background: Brucellosis is a bacterial infection, caused by the nonmotile gram-negative aerobic coccobacilli. The clinical manifestation of brucellosis is variable, ranging from mild disease to severe disease. The gold standard test to confirm the diagnosis of brucellosis is assaying blood, bone marrow, or other body fluids or by tissue culture. Preferred first-line treatment in adults with uncomplicated, nonlocalized disease consists of doxycycline-aminoglycoside combination. The recommended duration of treatment is 6 weeks...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29535097/a-case-of-tricuspid-valve-non-bacterial-thrombotic-endocarditis-presenting-as-pulmonary-embolism-in-a-patient-with-antiphospholipid-antibody-syndrome
#17
Dileep Unnikrishnan, Nasreen Shaikh, Ahmad Sharayah, Chandler Patton
A 47-year-old woman with a medical history of Raynaud's phenomenon presented with fever, cough and shortness of breath. She was found to have left lower lobe consolidation and pleural effusion and was treated as a case of pneumonia. During the hospital course, her respiratory status worsened, and she was intubated on the third hospital day. To investigate the high A-a gradient, a Computerized Tomographic Pulmonary Embolism (CTPE) study was done which identified a large left lower pulmonary artery embolism. She was also found to have a new murmur, and an echocardiogram demonstrated a large lesion on tricuspid valve...
March 13, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29534850/a-successful-salvage-therapy-with-daptomycin-and-linezolid-for-right-sided-infective-endocarditis-and-septic-pulmonary-embolism-caused-by-methicillin-resistant-staphylococcus-aureus
#18
Megumi Yazaki, Takehiko Oami, Kazuya Nakanishi, Ryota Hase, Hiroyuki Watanabe
Although vancomycin administration is recommended for the treatment of infective endocarditis (IE) caused by methicillin-resistant Staphylococcus aureus (MRSA), it is unclear whether an alternative agent, daptomycin, can be used to treat IE with pulmonary complications. A 26-year-old female who had undergone surgical repair of a ventricular septal defect as an early teenager presented with fever, headache, and vomiting. She was admitted to our hospital and diagnosed with right-sided IE with septic pulmonary embolism caused by MRSA...
March 10, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29492935/trends-in-infective-endocarditis
#19
Khadija Mzoughi, Ihsen Zairi, Samia Ben Hamida, Sofien Kamoun, Fethia Ben Moussa, Sana Fennira, Sondos Kraiem
INTRODUCTION: Infectious endocarditis (IE) is a rare disease with a high mortality. In 2009, the European society of cardiology restricted antibiotic prophylaxis to a smaller number of cardiac conditions with very high risk for IE. Did these changes in the guidelines have an impact on the epidemiological and bacteriological profile of IE? AIM: The main aim of our work was to study the evolution of the microbiological profile of IE from 1991 to 2016. METHODS: We realized an analytic retrospective study comparing two groups: group 1 included patients admitted for a certain IE before September 2009 and group 2 those admitted after that date...
April 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29488578/-non-bacterial-thrombotic-endocarditis-report-of-one-case
#20
Alejandra Salinas G, Luis Bustamante H, Fernando Lanas Z, Alvaro Soto V, María Angélica García B, Constanza Bartolotti H
Marantic or nonbacterial thrombotic endocarditis is characterized for the presence of vegetations formed by a meshwork of fibrin and other cellular material similar a blood clot, without the presence of microorganisms. It is often related with tumors and chronic inflammatory states. We report a 49 years old female with a history of weight loss and asthenia, presenting with multiple cerebrovascular attacks and fever. Blood cultures were negative and the fever did not subside with antibiotic treatment. Trans esophageal echocardiogram showed a mitral valve vegetation and thickening of the free edge of both leaflets...
October 2017: Revista Médica de Chile
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