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Blood culture negative endocarditis

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https://www.readbyqxmd.com/read/29419663/emphysematous-endocarditis-caused-by-ampc-beta-lactamase-producing-escherichia-coli-a-case-report
#1
Chung-Jong Kim, Jeong-Eun Yi, Yookyung Kim, Hee Jung Choi
RATIONALE: Infective endocarditis (IE) is a life-threatening disease, mostly caused by gram-positive bacteria. Gram-negative bacteria were identified as a causative organism in relatively small number of cases. Although, antibiotic-resistant Escherichia coli is common cause of gram-negative endocarditis, AmpC beta-lactamase (BL)-harboring E coli is very rare cause of IE. Furthermore, emphysematous endocarditis is also a very rare manifestation of E coli infection. PATIENT CONCERNS: We report a case of 80-year-old female patient presenting with dizziness, fever, and altered mental status, who was finally diagnosed with emphysematous endocarditis caused by E coli harboring an AmpC BL gene...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29417312/lessons-learned-from-splenic-infarcts-with-fever-of-unknown-origin-fuo-culture-negative-endocarditis-cne-or-malignancy
#2
REVIEW
Burke A Cunha, Bertamaria Dieguez, Alena Varantsova
Culture negative endocarditis (CNE) is a common concern in patients with fever, heart murmur, cardiac vegetation, and negative blood cultures. The diagnosis of CNE is not based only on negative blood cultures and a cardiac vegetation. The clinical definition of CNE is based on negative blood cultures plus the findings of culture positive infective endocarditis (IE), e.g., fever, cardiac vegetation, splenomegaly, peripheral manifestations. Because embolic splenic infarcts may occur with culture positive IE, some may assume that splenic infarcts are a sign of CNE...
February 7, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29390335/fever-of-unknown-origin-and-splenomegaly-a-case-report-of-blood-culture-negative-endocarditis
#3
Maria Livia Burzo, Mariangela Antonelli, Giovanni Pecorini, Angela M R Favuzzi, Raffaele Landolfi, Andrea Flex
RATIONALE: Fever of unknown origin (FUO) can be determined by different conditions among which infectious diseases represent the main cause. PATIENT CONCERNS: A young woman, with a history of aortic stenosis, was admitted to our unit for a month of intermittent fever associated with a new diastolic heart murmur and splenomegaly. Laboratory tests were negative for infectious screening. The total body computed tomography (CT) scan excluded abscesses, occulted neoplasia, or lymphadenopathy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381916/blood-culture-negative-endocarditis-improving-the-diagnostic-yield-using-new-diagnostic-tools
#4
Pierre-Edouard Fournier, Frédérique Gouriet, Jean-Paul Casalta, Hubert Lepidi, Hervé Chaudet, Franck Thuny, Frédéric Collart, Gilbert Habib, Didier Raoult
Blood culture-negative endocarditis (BCNE) may represent up to 70% of all endocarditis cases, depending on series. From 2001 to 2009, we implemented in our laboratory a multimodal diagnostic strategy for BCNE that included systematized testing of blood, and when available, valvular biopsy specimens using serological, broad range molecular, and histopathological assays. A causative microorganism was identified in 62.7% of patients.In this study from January 2010 to December 2015, in an effort to increase the number of identified causative microorganisms, we prospectively added to our diagnostic protocol specific real-time (RT) polymerase chain reaction (PCR) assays targeting various endocarditis agents, and applied them to all patients with BCNE admitted to the 4 public hospitals in Marseille, France...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29296269/clinicomicrobiological-spectrum-of-infective-endocarditis-from-a-tertiary-care-centre-in-south-india
#5
Kanne Padmaja, Sukanya Sudhaharan, Lakshmi Vemu, Oruganti Sai Satish, Padmasri Chavali, Mamidi Neeraja
Background and Objectives: Infective endocarditis (IE) is a microbial infection of the endothelial surface of the cardiac-valves. Rapid diagnosis, effective treatment and prompt recognition of complications are essential, in order to improve the outcome. We retrospectively reviewed and determined the clinical characteristics, microbiological profile and management strategies of IE cases, changing microbial spectrum of pathogens and outcome in Native Valve Endocarditis (NVE) and Prosthetic Valve Endocarditis (PVE) cases...
October 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29187685/-a-case-of-subarachnoid-hemorrhage-due-to-infective-endocarditis-by-methicillin-resistant-coagulase-negative-staphylococcus
#6
Shunsuke Kajikawa, Tomoko Oeda, Kwiyoung Park, Kenji Yamamoto, Hiroshi Sugiyama, Hideyuki Sawada
A 77-year-old man visited our hospital with unstable gait following 2 months of anorexia. Brain MRI showed multiple infarcts; cardiac echocardiography revealed mitral-valve vegetation; and blood culture revealed methicillin-resistant coagulase-negative staphylococci. The patient was diagnosed with infective endocarditis (IE). Subarachnoid hemorrhage (SAH) developed ten days after antibiotic treatment. Intracranial aneurysm was not found. We speculated that chronic inflammation of the cerebral arterial walls by bacteria of low virulence was associated with SAH complication...
November 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29121980/a-complicated-prosthetic-valve-endocarditis-due-to-methicillin-resistant-staphylococci-treated-with-linezolid-and-ciprofloxacin-a-case-report
#7
C G K Amiyangoda, H Wimalaratna, S Bowatte
BACKGROUND: Prosthetic valve endocarditis (PVE) due to methicillin resistant Staphylococcus aureus (MRSA) is a rare disease with significant mortality and morbidity. With the emerging resistance and adverse effect profile of vancomycin which is the standard treatment, there is a compelling necessity of an effective alternative for vancomycin. Linezolid is proved as such an agent for infections caused by MRSA in other sites. However to-date the evidence for successful use of linezolid for MRSA prosthetic valve endocarditis is limited only for few case studies...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29096006/treatment-of-prosthetic-valve-endocarditis-by-aortic-valve-neocuspidization-using-bovine-pericardium
#8
Yasunori Iida, Kazuma Shimura, Sho Akiyama, Shigeharu Sawa
A 78-year-old man who had undergone aortic valve and ascending aorta replacements presented with fever and was referred to our hospital. Blood culture revealed Gram-positive cocci, thus antibiotic therapy was started. Brain magnetic resonance imaging showed fresh cerebral infarction without cerebral haemorrhage or mycotic aneurysm. Transoesophageal echocardiogram revealed a vegetation that was attached to the right coronary cusp. The patient underwent successful aortic valve neocuspidization using glutaraldehyde-treated bovine pericardium...
October 31, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29089026/first-case-report-of-endocarditis-caused-by-haematobacter-massiliensis-in-china
#9
Jing-Wei Cheng, Peng Wang, Meng Xiao, Ying Yuan, Timothy Kudinha, Ying Zhao, Fanrong Kong, Ying-Chun Xu
BACKGROUND: Haematobacter massiliensis, a rare species of fastidious Gram-negative, non-motile, non-sporing, non-fermentative, pleomorphic, aerobic bacilli, has rarely been documented as the cause of infectious endocarditis in literature. Here we report the first case of infectious endocarditis (IE) caused by H. massiliensis in China. CASE PRESENTATION: A 44-year-old woman presented to the infectious department of Peking Union Medical College Hospital (Beijing) in August 2013, with a 7-week history of fevers, chills, sore throat, muscular soreness, occasional joint pain, and cough...
October 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29071745/anterior-mitral-valve-perforation-in-the-absence-of-acute-infection-diagnosis-by-two-dimensional-and-three-dimensional-transesophageal-echocardiography
#10
Mary Mashicharan, Peter J Cowburn, Steven A Livesey, Benoy N Shah
Anterior mitral valve leaflet (AMVL) perforation is most commonly seen in the setting of infective endocarditis. We present a case of AMVL perforation in a previously healthy 62-year-old male who presented with a six-month history of worsening dyspnea and peripheral edema. Blood cultures, inflammatory markers, and autoimmune profile were negative. Transthoracic echocardiography demonstrated severe mitral regurgitation (MR) with a possible AMVL perforation, which was confirmed by three-dimensional transesophageal echocardiography as a well-circumscribed hole in the A2 segment...
October 26, 2017: Echocardiography
https://www.readbyqxmd.com/read/29050353/combined-efficacy-of-c-reactive-protein-and-red-blood-cell-distribution-width-in-prognosis-of-patients-with-culture-negative-infective-endocarditis
#11
Xue-Biao Wei, Yuan-Hui Liu, Peng-Cheng He, Ying-Ling Zhou, Ning Tan, Ji-Yan Chen, Dan-Qing Yu
OBJECTIVE: To evaluate the combined effect of C-reactive protein (CRP) and red blood cell distribution width (RDW) on the prediction of in-hospital and long-term poor outcomes in patients with blood culture-negative infective endocarditis (BCNE). RESULTS: Patients with high CRP and high RDW has the highest incidence of in-hospital death (2.3% vs. 7.8% vs. 5.6% vs. 17.5%, P < 0.001). CRP > 17.8 mg/L (odds ratio [OR]=2.41, 95% confidence interval [CI], 1.06-5...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048299/blood-culture-negative-endocarditis-morocco
#12
Najma Boudebouch, M'hammed Sarih, Abdelfattah Chakib, Salma Fadili, Drissi Boumzebra, Zahira Zouizra, Badie Azamane Mahadji, Hamid Amarouch, Didier Raoult, Pierre-Edouard Fournier
We investigated the microorganisms causing blood culture-negative endocarditis (BCNE) in Morocco. We tested 19 patients with BCNE by serologic methods, molecular methods, or both and identified Bartonella quintana, Staphylococcus aureus, Streptococcus equi, and Streptococcus oralis in 4 patients. These results highlight the role of these zoonotic agents in BCNE in Morocco.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29044345/first-report-of-granulicatella-sp-endocarditis-in-a-kidney-transplant-patient
#13
Flávio Jota de Paula, Precil Diego Miranda de Menezes Neves, Ramaiane Aparecida Bridi, Alice Tung Wan Song, Elias David-Neto
Granulicatella and Abiotrophia are genera of fastidious Gram-positive cocci commensal of the oral, genitourinary, and intestinal flora. We report the first case of infective endocarditis caused by Granulicatella sp. in a kidney transplant recipient. A 67-year-old male kidney transplant recipient was admitted to the hospital for investigation of fever, abdominal pain, and diarrhea. On physical examination, he was dehydrated. Laboratory tests identified impaired renal function (creatinine level of 15.5 mg/dl; reference, 3...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29044013/-acute-aortic-regurgitation-due-to-infective-endocarditis
#14
Claudia M Cortés, José H Casabé, Roberto R Favaloro, Héctor Raffaelli, Eduardo Dulbecco, José Abud, Fabián Salmo, Melina Riesco, Milagros Seijo, Eduardo Guevara
Acute aortic regurgitation (AAR) due to infective endocarditis (IE) is a serious disease and usually requires surgical treatment. Our study aims to compare the clinical, echocardiographic, and microbiological characteristics as well as in-hospital outcome of patients with AAR according to the severity of heart failure (HF) and to evaluate predictors of in-hospital mortality in a tertiary centre. In a prospective analysis, we compared patients with NYHA functional class I-II HF (G1) vs. functional class III-IV HF (G2)...
2017: Medicina
https://www.readbyqxmd.com/read/29043211/native-valve-endocarditis-caused-by-achromobacter-xylosoxidans-a-case-report-and-review-of-literature
#15
Caio Godoy Rodrigues, Jairo Rays, Marcia Yoshie Kanegae
Achromobacter xylosoxidans is a Gram-negative aerobic bacterium first described by Yabuuchi and Ohyama in 1971. A. xylosoxidans is frequently found in aquatic environments. Abdominal, urinary tract, ocular, pneumonia, meningitis, and osteomyelitis are the most common infections. Infective endocarditis is rare. As far as we know, until now, only 19 cases have been described, including this current report. We report the case of community-acquired native valve endocarditis caused by A. xylosoxidans in an elderly patient without a concomitant diagnosis of a malignancy or any known immunodeficiency...
July 2017: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29038738/a-case-of-infective-endocarditis-and-spinal-epidural-abscess-caused-by-streptococcus-mitis-bacteremia
#16
Victoria S Byrd, Attila S Nemeth
A 57-year-old man presented with abdominal pain, hematemesis, and melena. He reported taking high-dose ibuprofen for back pain and drinking several 24-ounce beers daily. Examination was remarkable for icteric sclera, poor dentition, tachycardia, and crescendo-decrescendo murmur at right upper sternal border, radiating to the carotids. Labs revealed leukocytosis, anemia, thrombocytopenia, and elevated liver function tests and INR. Endoscopy demonstrated antral ulcers, duodenitis, and esophagitis. Blood cultures were obtained and broad-spectrum antibiotics started; cultures later grew Streptococcus mitis, and antibiotic coverage was narrowed...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28948320/first-case-of-q-fever-endocarditis-involving-the-melody-%C3%A2-transcatheter-pulmonary-valve-in-an-afebrile-child
#17
Zakaria Jalal, Marie Duperril, Pierre-Emmanuel Séguéla, Cléa Melenotte, Julie Chabaneix, Didier Raoult, Jean-Benoit Thambo
In this article we report the first case of Q fever endocarditis in a 13 years old child with a percutaneous pulmonary Melody(®) valve. The patient had a new onset of Melody valve dysfunction associated with the combination of hepatosplenomegaly and pancytopenia but was afebrile. Although blood cultures were negative, we have further investigated in the direction of infective endocarditis by performing PCR detection and the serology of C. burnetii which were positive. A combination antibiotic therapy with doxycycline and hydroxychloroquine was started with good clinical evolution...
September 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28840988/utility-of-a-direct-16s-rdna-pcr-and-sequencing-for-etiological-diagnosis-of-infective-endocarditis
#18
Min Sun Kim, Jeonghyun Chang, Mi Na Kim, Sang Ho Choi, Sung Ho Jung, Jae Won Lee, Heungsup Sung
BACKGROUND: Cases of infective endocarditis (IE) require prompt etiological diagnosis for effective treatment. Molecular methods can aid in rapid and reliable diagnosis of culture-negative IE cases. We evaluated the utility of 16S rDNA PCR and sequencing in determining the causative agents of IE in valve tissues, especially when specimens were obtained after initiation of antimicrobial therapy. METHODS: We performed 16S rDNA PCR and sequencing in heart valve specimens and medical records review of 80 patients who underwent protocol-based cardiac surgery from 2013 to 2015...
November 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28747418/a-complication-of-meningitis-and-infective-endocarditis-due-to-streptococcus-pyogenes
#19
Kosuke Inoue, Akiyoshi Hagiwara, Akio Kimura, Norio Ohmagari
We described a rare case of meningitis and infective endocarditis (IE) due to Streptococcus pyogenes. An 80-year-old woman was admitted to our hospital with unconsciousness. Glasgow Coma Scale was E1V3M5. We diagnosed her with acute meningitis due to S. pyogenes and started treatment using ceftriaxone. In spite of the improvement of her unconscious state, she developed a new-onset systolic murmur on day 13, and echocardiography revealed severe mitral valve regurgitation with vegetation. Therefore, we also diagnosed her with IE and continued the antibiotics for 6 weeks after we confirmed the negative blood cultures...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28719311/infective-endocarditis-in-french-west-indies-a-13-year-observational-study
#20
COMPARATIVE STUDY
Elisabeth Fernandes, Claude Olive, Jocelyn Inamo, François Roques, André Cabié, Patrick Hochedez
We conducted an observational study to describe the characteristics of infective endocarditis (IE) in French West Indies (FWI) and to identify variables associated with in-hospital case fatality. The records of the patients admitted for IE to the University Hospital of Martinique between 2000 and 2012 were collected using an electronic case report form. Only Duke-Li definite cases were considered for this analysis. Variables associated with in-hospital mortality were tested using univariate logistic regression analysis...
July 2017: American Journal of Tropical Medicine and Hygiene
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