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sweating in Parkinsonism

Timo Siepmann, Elka Frenz, Ana Isabel Penzlin, Susan Goelz, Wagner Zago, Ingeborg Friehs, Marie Luise Kubasch, Miriam Wienecke, Matthias Löhle, Wiebke Schrempf, Kristian Barlinn, Joachim Siegert, Alexander Storch, Heinz Reichmann, Ben Min-Woo Illigens
INTRODUCTION: Autonomic nervous system disturbances including sweating abnormalities and cardiovascular symptoms are frequent in Parkinson's disease (PD) and often precede motor involvement. Cholinergic vasomotor and sudomotor skin nerves are impaired in patients with PD even at early disease stages. We hypothesized that adrenergic pilomotor nerve function is similarly impaired in early PD and might constitute a novel diagnostic target. METHODS: We conducted a study in 12 PD patients (Hoehn&Yahr 1-2) and 12 healthy control subjects...
October 2016: Parkinsonism & related Disorders
René Günther, Nicole Richter, Anna Sauerbier, Kallol Ray Chaudhuri, Pablo Martinez-Martin, Alexander Storch, Andreas Hermann
BACKGROUND: The recently postulated "disease spreading hypothesis" has gained much attention, especially for Parkinson's disease (PD). The various non-motor symptoms (NMS) in neurodegenerative diseases would be much better explained by this hypothesis than by the degeneration of disease-specific cell populations. Motor neuron disease (MND) is primarily known as a group of diseases with a selective loss of motor function. However, recent evidence suggests disease spreading into non-motor brain regions also in MND...
2016: Frontiers in Neurology
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Since previous studies aimed to study nonmotor symptom (NMS) fluctuations in direct conjunction with motor oscillations, there are no data available on the temporal context of NMS fluctuations and motor oscillations in advanced Parkinson's disease (PD). OBJECTIVE: To evaluate circadian patterns and temporal connections of NMS and motor fluctuations in PD. METHODS: 15 controls, 17 non-fluctuating and 15 fluctuating PD patients completed two diaries by rating 4 key psychiatric (anxiety, depressive mood, inner restlessness, concentration/attention deficits), fatigue and 4 autonomic NMS (excessive sweating, sialorrhea, bladder urgency, dizziness) absent or present and motor function (Off, On with/without dyskinesia, and asleep) for every hour for 5 consecutive days...
May 31, 2016: Journal of Parkinson's Disease
Masaaki Hirayama, Makoto Tsunoda, Mitsutoshi Yamamoto, Takao Tsuda, Kinji Ohno
BACKGROUND: Noninvasive biomarkers for Parkinson's disease (PD) are currently unavailable. OBJECTIVE: To search for a biomarker unique to PD in sweat and serum. METHODS: Sweat samples in 42 PD patients and 16 controls were analyzed using liquid chromatography/mass spectrometry (LC/MS). The principal component analysis (PCA) and the orthogonal projections to latent structures (OPLS) analysis were employed. Serum Phe and Tyr levels were determined using the HPLC-fluorescence detection system in 28 de novo PD patients, 52 L-Dopa-treated PD patients, and 27 controls...
April 2, 2016: Journal of Parkinson's Disease
Christine Hosp, Markus K Naumann, Henning Hamm
Primary focal hyperhidrosis is a common autonomic disorder that significantly impacts quality of life. It is characterized by excessive sweating confined to circumscribed areas, such as the axillae, palms, soles, and face. Less frequent types of focal hyperhidrosis secondary to underlying causes include gustatory sweating in Frey's syndrome and compensatory sweating in Ross' syndrome and after sympathectomy. Approval of onabotulinumtoxinA for severe primary axillary hyperhidrosis in 2004 has revolutionized the treatment of this indication...
February 2016: Seminars in Neurology
Syed Yaseen Naqvi, Jeffrey J Luebbert, Stephen G Rosen
A 44-year-old woman with no medical history presented to the emergency department with a 2 h history of sudden onset chest pressure, palpitations, diaphoresis and shortness of breath. She reported a 90-pound unintentional weight loss, increased appetite, irritability, night sweats and palpitations for 2 months. Physical examination revealed a heart rate (HR) of 269 bpm and a blood pressure of 116/94 mm Hg. Her ECG revealed a wide-complex tachycardia with right bundle branch morphology and an HR of 265 bpm. Intravenous adenosine was administered with resolution of the arrhythmia and symptoms...
2015: BMJ Case Reports
Xiao-Hong Wang, Lin Zhang, Laura Sperry, John Olichney, Sarah Tomaszewski Farias, Kiarash Shahlaie, Norika Malhado Chang, Ying Liu, Su-Ping Wang, Cui Wang
OBJECTIVE: This review examines the evidence that deep brain stimulation (DBS) has extensive impact on nonmotor symptoms (NMSs) of patients with Parkinson's disease (PD). DATA SOURCES: We retrieved information from the PubMed database up to September, 2015, using various search terms and their combinations including PD, NMSs, DBS, globus pallidus internus (GPi), subthalamic nucleus (STN), and ventral intermediate thalamic nucleus. STUDY SELECTION: We included data from peer-reviewed journals on impacts of DBS on neuropsychological profiles, sensory function, autonomic symptoms, weight changes, and sleep disturbances...
December 20, 2015: Chinese Medical Journal
A Mrochen, F Marxreiter, Z Kohl, J Schlachetzki, B Renner, T Schenk, J Winkler, J Klucken
INTRODUCTION: Olfactory dysfunction and neuropsychological symptoms like depression and anhedonia are common non-motor symptoms in Parkinson's disease (PD). The assessment of both functional domains includes clinical examination, olfactory testing, and standardized questionnaires. While olfaction is readily assessed by functional tests, the distinction of anhedonia as a separate symptom from other depressive symptoms is challenging. Thus, a test focusing on the assessment of hedonic olfaction may be helpful in the assessment of neuropsychological symptoms in PD...
January 2016: Parkinsonism & related Disorders
Lindsay Cox, Dirk K Vanderwall, Kate C Parkinson, Alexis Sweat, S Clay Isom
There is compelling evidence that oocytes from mares >18 years of age have a high incidence of inherent defects that result in early embryonic loss. In women, an age-related decrease in oocyte quality is associated with an increased incidence of aneuploidy and it has recently been determined that the gene expression profile of human oocytes is altered with advancing age. We hypothesised that similar age-related aberrations in gene expression occur in equine oocytes. Therefore, the aim of the present study was to compare gene expression profiles of individual oocytes and cumulus cells from young and aged mares, specifically evaluating genes that have been identified as being differentially expressed with advancing maternal age and/or aneuploidy in human oocytes...
July 2015: Reproduction, Fertility, and Development
Chifumi Iseki, Taiga Furuta, Masao Suzuki, Shingo Koyama, Keiji Suzuki, Tomoko Suzuki, Akiyo Kaneko, Tadamichi Mitsuma
A woman started to feel intractable pain on her lower legs when she was 76. At the age of 78, she was diagnosed as having Parkinson's disease (PD). The leg pain was suspected to be a symptom of PD after eliminating other causes. The patient also suffered from nonmotor symptoms, depression, anxiety, hot flashes, and paroxysmal sweating. Though the patient had received pharmacotherapy including levodopa for 5 years, she still suffered from the nonmotor symptoms and was referred to our department. We treated her with acupuncture based on the Chinese traditional medicine and electroacupuncture five times per week...
2014: Case Reports in Neurological Medicine
Makoto Tsunoda, Masaaki Hirayama, Takao Tsuda, Kinji Ohno
BACKGROUND: L-dopa (l-3,4-dihydroxyphenylalanine) is commonly used for treating Parkinson's disease (PD). However, regardless of its prominent effect, therapeutic range of L-dopa narrows down with disease progression, which leads to development of motor complications including wearing off and dyskinesias. In addition, intestinal absorption of L-dopa is inversely correlated with the amount of oral protein intake, and shows intra- and inter-day variability. Hence, frequent monitoring of plasma L-dopa concentrations is beneficial, but frequent venipuncture imposes physical and psychological burdens on patients with PD...
March 10, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
Judith Navarro-Otano, Jordi Casanova-Mollà, Merche Morales, Josep Valls-Solé, Eduard Tolosa
Numerous studies have detailed involvement of the peripheral autonomic nervous system (PANS) in Parkinson's disease (PD). We assessed autonomic innervation of dermal annexes through quantitative fluorescence measurement from skin obtained via punch biopsies at distal leg region in PD and control subjects. We defined a ratio between the area corresponding to protein gen product (PGP) immunoreactivity and the area corresponding to blood vessel or sweat gland as a quantitative measure of autonomic innervation...
August 2015: Journal of Neural Transmission
Claustre Pont-Sunyer, Anna Hotter, Carles Gaig, Klaus Seppi, Yaroslau Compta, Regina Katzenschlager, Natalia Mas, Dominik Hofeneder, Thomas Brücke, Angels Bayés, Karoline Wenzel, Jon Infante, Heidemarie Zach, Walter Pirker, Ignacio J Posada, Ramiro Álvarez, Lourdes Ispierto, Oriol De Fàbregues, Antoni Callén, Antoni Palasí, Miquel Aguilar, Maria José Martí, Francesc Valldeoriola, Manel Salamero, Werner Poewe, Eduardo Tolosa
Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor symptoms. Relationship between premotor symptoms onset and motor features is limited. Our aim is to describe the presence and perceived onset of NMS in PD as well as their possible association with motor phenotype. Presence and onset of NMS were assessed by a custom-made questionnaire in 109 newly diagnosed untreated PD patients and 107 controls from 11 Spanish and Austrian centers. Seventeen of thirty-one NMS were more common in patients than controls (P < 0...
February 2015: Movement Disorders: Official Journal of the Movement Disorder Society
Ari Ylikoski, Kirsti Martikainen, Markku Partinen
BACKGROUND: Sleep disorders are among the most common non-motor symptoms in Parkinson's disease. METHOD: The prevalence of parasomnias and their association with other symptoms were studied in a questionnaire study among 1447 randomly selected Parkinson patients, aged 43 to 89 years. The response rate was 59.0% and of these 77% had answered to all questions that were used in the analyses (N = 661). RESULTS: The prevalence of REM sleep behavior disorder (RBD) evaluated by the RBDSQ ≥ 6 was 39...
November 15, 2014: Journal of the Neurological Sciences
Ruwei Ou, Xiaoyan Guo, Wei Song, Bei Cao, Qianqian Wei, Na Shao, Bi Zhao, Huifang Shang
OBJECTIVE: This study aims to investigate the differences in the prevalence and severity of NMS between patients with Parkinson's disease (PD) who manifest camptocormia and those who do not manifest camptocormia. METHODS: A total of 50 PD patients with camptocormia and 50 gender and disease duration 1:1 matched patients with PD but without camptocormia were included in this case-control study. The severity of motor symptoms was assessed with the Unified PD Rating Scale (UPDRS) part III and Hoehn and Yahr (H&Y) staging...
July 2014: Gait & Posture
Nicola Modugno, Francesco Lena, Francesca Di Biasio, Gloria Cerrone, Stefano Ruggieri, Francesco Fornai
Although Parkinson's disease (PD) is diagnosed on the basis of motor symptoms, including slowness of movement, tremor, rigidity and difficulties with balance and walking, now we are aware that non-motor symptoms are highly prevalent, since they can anticipate motor symptoms and can cause severe consequences. Several studies have shown that non-motor symptoms, such as depression, anxiety and apathy, psychosis (e.g., hallucinations, delusions), sleep disturbance, and pain may have a greater adverse impact on quality of life and health economics compared with motor symptoms...
December 2013: Archives Italiennes de Biologie
M M Rahman, M J Uddin, J H Chowdhury, T I Chowdhury
Parkinson's disease (PD) patient presents with both motor and non-motor symptoms. This was descriptive type of interventional study carried out in the department of Neurology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from January 2009 to December 2010. Among the total 59 cases, 51 completed the proposed five months follow up. The rest eight cases attended Neurology department irregularly and were ultimately dropout from follow up. The case selection technique was purposive type of non probability sampling...
January 2014: Mymensingh Medical Journal: MMJ
Masato Asahina, Christopher J Mathias, Akira Katagiri, David A Low, Ekawat Vichayanrat, Yoshikatsu Fujinuma, Yoshitaka Yamanaka, Satoshi Kuwabara
BACKGROUND: According to Braak staging of Parkinson's disease (PD), detection of autonomic dysfunction would help with early diagnosis of PD. OBJECTIVE: To determine whether the autonomic nervous system is involved in the early stage of PD, we evaluated cardiovascular and sudomotor function in early untreated PD patients. METHODS: Orthostatic blood pressure regulation, heart rate variability, skin vasomotor function, and palmar sympathetic sweat responses were examined in 50 early untreated PD patients and 20 healthy control subjects...
2014: Journal of Parkinson's Disease
Yingli Wang, Yang Dan, Dawei Yang, Yuli Hu, Le Zhang, Chunhong Zhang, Hong Zhu, Zhanhu Cui, Minhui Li, Yanze Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Anemarrhena asphodeloides Bunge. (Asparagaceae) yields Anemarrhenae Rhizoma, which has a long history to be used as a traditional medicine to treat various ailments, like cold-induced febrile disease with arthralgia, hematochezia, tidal fever and night sweats by Yin deficiency, bone-steaming, cough, and hemoptysis. It is also used as an ingredient of healthy food, wine, tea, biological toothpaste. Its importance is demonstrated by large scale to treat kinds of diseases in eastern Asian countries...
April 11, 2014: Journal of Ethnopharmacology
Xiaoyan Guo, Wei Song, Ke Chen, XuePing Chen, Zhenzhen Zheng, Bei Cao, Rui Huang, Bi Zhao, Ying Wu, Hui-Fang Shang
The differences in non-motor symptoms (NMS) along with the duration of Parkinson's disease (PD) in Chinese populations remain largely unknown. A total of 616 PD patients consisting of 189 patients with disease duration of less than 2years, 239 patients with duration between 2 and 5years, 122 patients with duration between 5 and 10years, and 66 patients with duration more than 10years from Southwest China were studied. Each patient was assessed using the non-motor symptoms scale (NMSS). The mean affected number of NMS was 8...
July 15, 2013: Journal of the Neurological Sciences
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