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WNT7a

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https://www.readbyqxmd.com/read/29285041/wnt7a-deficiency-could-predict-worse-disease-free-and-overall-survival-in-estrogen-receptor-positive-breast-cancer
#1
Kijong Yi, Kyueng-Whan Min, Young Chan Wi, Yeseul Kim, Su-Jin Shin, Min Sung Chung, Kiseok Jang, Seung Sam Paik
Purpose: Wnt7a is a glycoprotein involved in embryonic development and the progression of different types of malignant tumors. This study aimed to detect the level of Wnt7a expression in breast cancer and explore its role in the disease progression and prognosis. Methods: A total of 258 patients diagnosed with invasive ductal carcinoma of the breast were included in this study. Using tissue microarray and immunohistochemical staining, we evaluated the association between Wnt7a expression and clinicopathological parameters, and the prognostic value of Wnt7a...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29201214/sirt1-regulates-apoptosis-and-extracellular-matrix-degradation-in-resveratrol-treated-osteoarthritis-chondrocytes-via-the-wnt-%C3%AE-catenin-signaling-pathways
#2
Shuan Liu, Hongping Yang, Bing Hu, Mingyong Zhang
Osteoarthritis (OA) has become a major public health problem with the increased aging population. Previous studies have demonstrated that resveratrol (RES) was able to increase the level of sirtuin 1 (Sirt1) in OA chondrocytes. However, further investigations are required to elucidate the precise molecular mechanism of RES and the potential link between Sirt1 and RES. Therefore, the present study used 30 clinical OA chondrocyte to examine chondrocyte viability, apoptosis rate and the mRNA and protein expression levels of Sirt1 and relevant genes implicated in apoptosis, extracellular matrix (ECM) degradation and Wnt/β-catenin signaling pathway...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29186616/junb-governs-a-feed-forward-network-of-tgf%C3%AE-signaling-that-aggravates-breast-cancer-invasion
#3
Anders Sundqvist, Masato Morikawa, Jiang Ren, Eleftheria Vasilaki, Natsumi Kawasaki, Mai Kobayashi, Daizo Koinuma, Hiroyuki Aburatani, Kohei Miyazono, Carl-Henrik Heldin, Hans van Dam, Peter Ten Dijke
It is well established that transforming growth factor-β (TGFβ) switches its function from being a tumor suppressor to a tumor promoter during the course of tumorigenesis, which involves both cell-intrinsic and environment-mediated mechanisms. We are interested in breast cancer cells, in which SMAD mutations are rare and interactions between SMAD and other transcription factors define pro-oncogenic events. Here, we have performed chromatin immunoprecipitation (ChIP)-sequencing analyses which indicate that the genome-wide landscape of SMAD2/3 binding is altered after prolonged TGFβ stimulation...
November 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29161339/astrocyte-specific-deletion-of-sox2-promotes-functional-recovery-after-traumatic-brain-injury
#4
Chunhai Chen, Xiaoling Zhong, Derek K Smith, Wenjiao Tai, Jianjing Yang, Yuhua Zou, Lei-Lei Wang, Jiahong Sun, Song Qin, Chun-Li Zhang
Injury to the adult brain induces activation of local astrocytes, which serves as a compensatory response that modulates tissue damage and recovery. However, the mechanism governing astrocyte activation during brain injury remains largely unknown. Here we provide in vivo evidence that SOX2, a transcription factor critical for stem cells and brain development, is also required for injury-induced activation of adult cortical astrocytes. Genome-wide chromatin immunoprecipitation-seq analysis of mouse cortical tissues reveals that SOX2 binds to regulatory regions of genes associated with signaling pathways that control glial cell activation, such as Nr2e1, Mmd2, Wnt7a, and Akt2...
November 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29128220/identification-of-potential-embryokines-in-the-bovine-reproductive-tract
#5
P Tríbulo, L G B Siqueira, L J Oliveira, T Scheffler, P J Hansen
Knowledge of the molecules used by the maternal reproductive tract to regulate development of the preimplantation embryo is largely incomplete. The goal of the present experiment was to identify candidates for this function. The approach was to assess expression patterns in the endometrium and oviduct of 93 genes encoding for hormones, growth factors, chemokines, cytokines, and WNT-related molecules. Results show that all of the genes were expressed in the reproductive tract. Expression in oviduct was affected by day of the estrous cycle for 21 genes with 11 genes having highest expression at estrus (CCL21, CTGF, CXCL10, CXCL16, DKK3, FGF10, IL18, IL33, IL34, PGF, and SFRP2), one gene at d 3 (WNT4), 8 at d 5 (BMP7, HGF, IL6, SFRP1, TGFB1, WIF1, WNT2, and WNT5A), and one at d 7 (IK)...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29107840/the-wnt-%C3%AE-catenin-signaling-in-endometriosis-the-expression-of-total-and-active-forms-of-%C3%AE-catenin-total-and-inactive-forms-of-glycogen-synthase-kinase-3%C3%AE-wnt7a-and-dickkopf-1
#6
Azar Pazhohan, Fardin Amidi, Firoozeh Akbari-Asbagh, Ensiyeh Seyedrezazadeh, Laya Farzadi, Mahshad Khodarahmin, Shayesteh Mehdinejadiani, Aligholi Sobhani
OBJECTIVES: The cyclical changes in proliferation and differentiation of endometrial cells are regulated by estrogen and progesterone via modulating Wnt/β-catenin signaling. Imbalance in the expression of estrogen and progesterone receptors causes progesterone resistance in endometriosis patients. The aim of this study was to investigate the expression of some main components of Wnt/β-catenin signaling including WNT7a, DKK-1, β-catenin, and GSK-3β in eutopic endometrium and peritoneal endometriotic lesions of endometriosis patients compared to healthy endometrium in the mid-secretory phase of menstrual cycle...
October 31, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28917830/al-awadi-raas-rothschild-syndrome-with-dental-anomalies-and-a-novel-wnt7a-mutation
#7
Piranit Nik Kantaputra, Seema Kapoor, Prashant Verma, Massupa Kaewgahya, Katsushige Kawasaki, Atsushi Ohazama, James R Ketudat Cairns
Al-Awadi-Raas-Rothschild syndrome (AARRS; OMIM 276820) is a very rare autosomal recessive limb malformation syndrome caused by WNT7A mutations. AARRS is characterized by various degrees of limb aplasia and hypoplasia. Normal intelligence and malformations of urogenital system are frequent findings. Complete loss of WNT7A function has been shown to cause AARRS, however, its partial loss leads to the milder malformation, Fuhrmann syndrome. An Indian boy affected with AARRS is reported. A novel homozygous base substitution mutation c...
September 14, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28872671/wnt7a-induces-a-unique-phenotype-of-monocyte-derived-macrophages-with-lower-phagocytic-capacity-and-differential-expression-of-pro-and-anti-inflammatory-cytokines
#8
Jennillee Wallace, Victoria Lutgen, Sreedevi Avasarala, Brad St Croix, Robert A Winn, Lena Al-Harthi
The variation of macrophage functions suggests the involvement of multiple signalling pathways in fine tuning their differentiation. Macrophages that originate from monocytes in the blood migrate to tissue in response to homeostatic or 'danger' signals and undergo substantial morphological and functional modifications to meet the needs of the dominant signals in the microenvironment. Wnts are secreted glycoproteins that play a significant role in organ and cell differentiation, yet their impact on monocyte differentiation is not clear...
September 5, 2017: Immunology
https://www.readbyqxmd.com/read/28858622/reck-and-gpr124-are-essential-receptor-cofactors-for-wnt7a-wnt7b-specific-signaling-in-mammalian-cns-angiogenesis-and-blood-brain-barrier-regulation
#9
Chris Cho, Philip M Smallwood, Jeremy Nathans
No abstract text is available yet for this article.
August 30, 2017: Neuron
https://www.readbyqxmd.com/read/28855715/santos-syndrome-is-caused-by-mutation-in-the-wnt7a-gene
#10
Leandro U Alves, Silvana Santos, Camila M Musso, Suzana Am Ezquina, John M Opitz, Fernando Kok, Paulo A Otto, Regina C Mingroni-Netto
We have recently described a family with a condition (Santos syndrome (SS; MIM 613005)) characterized by fibular agenesis/hypoplasia, hypoplastic femora and grossly malformed/deformed clubfeet with severe oligodactyly, ungual hypoplasia/anonychia, sometimes associated with mild brachydactyly and occasional pre-axial polydactyly. Autosomal dominant inheritance with incomplete penetrance was suggested, but autosomal recessive inheritance could not be ruled out, due to the high frequency of consanguineous matings in the region where the family lived...
August 31, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28827448/egf-hijacks-mir-198-fstl1-wound-healing-switch-and-steers-a-two-pronged-pathway-toward-metastasis
#11
Gopinath M Sundaram, Hisyam M Ismail, Mohsin Bashir, Manish Muhuri, Candida Vaz, Srikanth Nama, Ghim Siong Ow, Ivshina Anna Vladimirovna, Rajkumar Ramalingam, Brian Burke, Vivek Tanavde, Vladimir Kuznetsov, E Birgitte Lane, Prabha Sampath
Epithelial carcinomas are well known to activate a prolonged wound-healing program that promotes malignant transformation. Wound closure requires the activation of keratinocyte migration via a dual-state molecular switch. This switch involves production of either the anti-migratory microRNA miR-198 or the pro-migratory follistatin-like 1 (FSTL1) protein from a single transcript; miR-198 expression in healthy skin is down-regulated in favor of FSTL1 upon wounding, which enhances keratinocyte migration and promotes re-epithelialization...
October 2, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28803732/reck-and-gpr124-are-essential-receptor-cofactors-for-wnt7a-wnt7b-specific-signaling-in-mammalian-cns-angiogenesis-and-blood-brain-barrier-regulation
#12
Chris Cho, Philip M Smallwood, Jeremy Nathans
Reck, a GPI-anchored membrane protein, and Gpr124, an orphan GPCR, have been implicated in Wnt7a/Wnt7b signaling in the CNS vasculature. We show here that vascular endothelial cell (EC)-specific reduction in Reck impairs CNS angiogenesis and that EC-specific postnatal loss of Reck, combined with loss of Norrin, impairs blood-brain barrier (BBB) maintenance. The most N-terminal domain of Reck binds to the leucine-rich repeat (LRR) and immunoglobulin (Ig) domains of Gpr124, and weakening this interaction by targeted mutagenesis reduces Reck/Gpr124 stimulation of Wnt7a signaling in cell culture and impairs CNS angiogenesis...
August 30, 2017: Neuron
https://www.readbyqxmd.com/read/28780397/neonatal-exposure-to-a-glyphosate-based-herbicide-alters-uterine-decidualization-in-rats
#13
Paola I Ingaramo, Jorgelina Varayoud, María M Milesi, Marlise Guerrero Schimpf, Ramiro Alarcón, Mónica Muñoz-de-Toro, Enrique H Luque
We investigated whether defective modulation of uterine signaling may cause decidualization failure in rats neonatally exposed to a glyphosate-based herbicide (GBH). Female pups received vehicle or 2mg/kg of GBH from postnatal day (PND) 1 to PND7. On PND8 and PND21, Wnt5a and β-catenin expression was evaluated in uterine samples. On gestational day (GD) 9, Wnt5a, Wnt7a and β-catenin expression and Dkk1 and sFRP4 mRNA were evaluated on implantation sites. On PND8, GBH-exposed rats showed increased Wnt5a and β-catenin expression in luminal epithelium (LE), whereas on PND21, they showed increased Wnt5a and β-catenin expression in subepithelial stroma but decreased β-catenin expression in glandular epithelium...
August 2, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28640224/nomegestrol-acetate-suppresses-human-endometrial-cancer-rl95-2-cells-proliferation-in-vitro-and-in-vivo-possibly-related-to-upregulating-expression-of-sufu-and-wnt7a
#14
A-Ying Ma, Shu-Wu Xie, Jie-Yun Zhou, Yan Zhu
Nomegestrol acetate (NOMAC) has been successfully used for the treatment of some gynecological disorders, and as a combined oral contraceptive with approval in many countries. In this study, we investigated the effects of NOMAC on human endometrial cancer cells in vitro and in vivo. The proliferation of human endometrial cancer cells (RL95-2 and KLE) were assessed using CCK-8 and EdU incorporation assays. Whole-genome cDNA microarray analysis was used to identify the effects of NOMAC on gene expression profiles in RL95-2 cells...
June 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28615674/meta-analysis-of-genome-wide-snp-and-pathway-based-associations-for-facets-of-neuroticism
#15
Song E Kim, Han-Na Kim, Yeo-Jun Yun, Seong Gu Heo, Juhee Cho, Min-Jung Kwon, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Chol Shin, Nam H Cho, Yeon Ah Sung, Hyung-Lae Kim
Neuroticism is a heritable personality trait that is comprised of distinct sub-factors, or facets. Sub-factors of neuroticism are linked to different emotional states or psychiatric symptoms and studying the genetic variants associated with these facets may help reveal the biological mechanisms underlying psychiatric disorders. In the present study, a meta-analysis of genome-wide association studies for six facets of neuroticism was performed in 5584 participants from three cohorts. Additionally, a Gene Set Enrichment Analysis was conducted to find biological pathways associated with each facet...
October 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28575156/consequences-of-endogenous-and-exogenous-wnt-signaling-for-development-of-the-preimplantation-bovine-embryo
#16
Paula Tribulo, Beatriz Caetano da Silva Leão, Khoboso C Lehloenya, Gisele Zoccal Mingoti, Peter J Hansen
The specific role of WNT signaling during preimplantation development remains unclear. Here, we evaluated consequences of activation and inhibition of β-catenin (CTNNB1)-dependent and -independent WNT signaling in the bovine preimplantation embryo. Activation of CTNNB1-mediated WNT signaling by the agonist 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) and a glycogen synthase kinase 3 inhibitor reduced development to the blastocyst stage. Moreover, the antagonist of WNT signaling, dickkopf-related protein 1 (DKK1), alleviated the negative effect of AMBMP on development via reduction of CTNNB1...
June 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28456695/paratubal-cyst-size-correlates-with-obesity-and-dysregulation-of-the-wnt-signaling-pathway
#17
Jennifer E Dietrich, Oluyemisi Adeyemi, Julie Hakim, Xiomara Santos, Jennifer L Bercaw-Pratt, Juan C Bournat, Ching H Chen, Carolina J Jorgez
STUDY OBJECTIVE: Paratubal cysts (PTCs) occur in 7%-10% of women, regardless of age. Although common, PTCs often are found incidentally because of the potential for these cysts to be asymptomatic. The specific aims of the study were to determine if PTC number and size correlated with signs of hyperandrogenism and obesity, as well as to investigate the molecular profiles of these PTCs in samples derived from female adolescents. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A prospective cohort study was performed in a single children's hospital...
October 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28434104/mullerian-dysgenesis-a-critical-review-of-the-literature
#18
REVIEW
Souzana Choussein, Dimitrios Nasioudis, Dimitrios Schizas, Konstantinos P Economopoulos
PURPOSE: To present an update of the genetic, clinical, diagnostic, and therapeutic aspects of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. METHODS: Studies were considered eligible if they have evaluated patients with MRKH syndrome. Eligible articles were identified by a search of MEDLINE bibliographical database from 1950 to August 2016. A purely descriptive approach was adopted concerning all outcomes examined by the individual studies. RESULTS: MRKH syndrome is defined as congenital aplasia of the upper vagina and impairment of uterine development in normal 46XX females...
June 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28409313/extracellular-regulation-of-the-mitotic-spindle-and-fate-determinants-driving-asymmetric-cell-division
#19
REVIEW
Prestina Smith, Mark Azzam, Lindsay Hinck
Stem cells use mode of cell division, symmetric (SCD) versus asymmetric (ACD), to balance expansion with self-renewal and the generation of daughter cells with different cell fates. Studies in model organisms have identified intrinsic mechanisms that govern this process, which involves partitioning molecular components between daughter cells, frequently through the regulation of the mitotic spindle. Research performed in vertebrate tissues is revealing both conservation of these intrinsic mechanisms and crucial roles for extrinsic cues in regulating the frequency of these divisions...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28356085/cnv-discovery-for-milk-composition-traits-in-dairy-cattle-using-whole-genome-resequencing
#20
Yahui Gao, Jianping Jiang, Shaohua Yang, Yali Hou, George E Liu, Shengli Zhang, Qin Zhang, Dongxiao Sun
BACKGROUND: Copy number variations (CNVs) are important and widely distributed in the genome. CNV detection opens a new avenue for exploring genes associated with complex traits in humans, animals and plants. Herein, we present a genome-wide assessment of CNVs that are potentially associated with milk composition traits in dairy cattle. RESULTS: In this study, CNVs were detected based on whole genome re-sequencing data of eight Holstein bulls from four half- and/or full-sib families, with extremely high and low estimated breeding values (EBVs) of milk protein percentage and fat percentage...
March 29, 2017: BMC Genomics
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