keyword
MENU ▼
Read by QxMD icon Read
search

Olfactory ensheathing cells

keyword
https://www.readbyqxmd.com/read/27895759/globose-cystic-olfactory-ensheathing-cell-tumor-a-case-report-and-literature-review
#1
Yaoling Liu, Minghai Wei, Kang Yang, Zeshi Tan, Xu Sun, Xinyu Li, Ningwei Che, Lan Luan, Guanyu Wang, Xiaofeng Wang, Yuqiang Sun, Jian Yin
Olfactory ensheathing cell tumor (OECT) is one of the most rare intracranial, extra-axial tumors located in the anterior cranial fossa. The present study reports a case of a 34-year-old female patient who presented with a history of hyposmia for 1 year, as well as a gradual dizziness and emotional lability for 2 months. Magnetic resonance imaging of the brain revealed a globose, well-defined cystic mass at the midline of the anterior cranial fossa, which was confirmed as an OECT by histology and was completely resected by bifrontal craniotomy...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27889433/the-protective-effect-of-curcumin-in-olfactory-ensheathing-cells-exposed-to-hypoxia
#2
Roberta Bonfanti, Teresa Musumeci, Cristina Russo, Rosalia Pellitteri
Curcumin, a phytochemical component derived from the rhizomes of Curcuma longa, has shown a great variety of pharmacological activities, such as anti-inflammatory, anti-tumor, anti-depression and anti-oxidant activity. Therefore, in the last years it has been used as a therapeutic agent since it confers protection in different neurodegenerative diseases, cerebral ischemia and excitotoxicity. Olfactory Ensheathing Cells (OECs) are glial cells of the olfactory system. They are able to secrete several neurotrophic growth factors, promote axonal growth and support the remyelination of damaged axons...
November 23, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27832687/subarachnoid-space-transplantation-of-schwann-and-or-olfactory-ensheathing-cells-following-severe-spinal-cord-injury-fails-to-improve-locomotor-recovery-in-rats
#3
Mohsen Nategh, Masoumeh Firouzi, Mehdi Naji-Tehrani, Leila Oryadi Zanjani, Zahra Hassannejad, Mohammad Hosein Nabian, Shayan Abdollah Zadegan, Mehrbod Karimi, Vafa Rahimi-Movaghar
Treatment of spinal cord injury by exogenous cells has brought both successful and unsuccessful results. Olfactory ensheathing cells and Schwann cells have been widely used for transplantation purposes. In this study, we investigated the effects of these cells on contused spinal cord by introducing cells into subarachnoid space. Fifty thousand Schwann cells or olfactory ensheathing cells or a mixture of both cell types were transplanted one week after a 3-second clip compression injury at T-9 spinal cord level in rats...
September 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27827453/streptococcus-pneumoniae-resists-intracellular-killing-by-olfactory-ensheathing-cells-but-not-by-microglia
#4
Hugo Macedo-Ramos, Susana Ruiz-Mendoza, Rafael M Mariante, Erick V Guimarães, Lucas C Quadros-de-Souza, Mauricio M Paiva, Eliane de O Ferreira, Tatiana C A Pinto, Lucia M Teixeira, Silvana Allodi, Wagner Baetas-da-Cruz
Olfactory ensheathing cells (OECs) are a type of specialized glial cell currently considered as having a double function in the nervous system: one regenerative, and another immune. Streptococcus pneumoniae is a major agent of severe infections in humans, including meningitis. It is commonly found in the nasopharynx of asymptomatic carriers, and, under certain still unknown conditions, can invade the brain. We evaluated whether pneumococcal cells recovered from lysed OECs and microglia are able to survive by manipulating the host cell activation...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27807758/olfactory-ensheathing-cell-conditioned-medium-reverts-a%C3%AE-25-35-induced-oxidative-damage-in-sh-sy5y-cells-by-modulating-the-mitochondria-mediated-apoptotic-pathway
#5
Qing-Qing Fu, Li Wei, Javier Sierra, Jian-Zhang Cheng, María Teresa Moreno-Flores, Hua You, Hua-Rong Yu
Olfactory ensheathing cells (OECs) are a type of glia from the mammalian olfactory system, with neuroprotective and regenerative properties. β-Amyloid peptides are a major component of the senile plaques characteristic of the Alzheimer brain. The amyloid beta (Aβ) precursor protein is cleaved to amyloid peptides, and Aβ25-35 is regarded to be the functional domain of Aβ, responsible for its neurotoxic properties. It has been reported that Aβ25-35 triggers reactive oxygen species (ROS)-mediated oxidative damage, altering the structure and function of mitochondria, leading to the activation of the mitochondrial intrinsic apoptotic pathway...
November 2, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27789279/conditioned-medium-of-olfactory-ensheathing-cells-promotes-the-functional-recovery-and-axonal-regeneration-after-contusive-spinal-cord-injury
#6
Mengchao Gu, Zhengchao Gao, Xiaohui Li, Lei Guo, Teng Lu, Yuhuan Li, Xijing He
OBJECTIVE: To investigate the effectiveness and the potential role of olfactory ensheathing cell conditioned medium (OEC-M) to treat contusive spinal cord injury (SCI). METHODS: The contusive SCI model was established by NYU weight-drop impactor at T10 segment. Male Sprague-Dawley rats received intraperitoneal injection of control medium (Con-M, n=18), low dose OEC-M (n=18) and high dose OEC-M (n=18). Immunofluorescence was performed to identify the purity of cultured OECs...
January 1, 2017: Brain Research
https://www.readbyqxmd.com/read/27757835/effect-of-some-growth-factors-on-tissue-transglutaminase-overexpression-induced-by-%C3%AE-amyloid-in-olfactory-ensheathing-cells
#7
Rosalia Pellitteri, Roberta Bonfanti, Michela Spatuzza, Maria Teresa Cambria, Mariacristina Ferrara, Giuseppina Raciti, Agata Campisi
Herein, we assessed in a particular glial cell type, called olfactory ensheathing cells (OECs), the effect of some growth factors (GFs) on tissue transglutaminase (TG2) overexpression induced by amyloid-beta (Aβ) with native full-length peptide 1-42 or by fragments, 25-35 or 35-25, as control. Previously, we demonstrated that TG2 overexpression induced by some stressors was down-regulated by GFs exposure in OECs. To monitor cell viability, an MTT test was used, while TG2 expression was examined using immunocytochemical and Western blot analysis...
October 18, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27757072/influence-of-biphasic-stimulation-on-olfactory-ensheathing-cells-for-neuroprosthetic-devices
#8
Rachelle T Hassarati, L John R Foster, Rylie A Green
The recent success of olfactory ensheathing cell (OEC) assisted regeneration of injured spinal cord has seen a rising interest in the use of these cells in tissue-engineered systems. Previously shown to support neural cell growth through glial scar tissue, OECs have the potential to assist neural network formation in living electrode systems to produce superior neuroprosthetic electrode surfaces. The following study sought to understand the influence of biphasic electrical stimulation (ES), inherent to bionic devices, on cell survival and function, with respect to conventional metallic and developmental conductive hydrogel (CH) coated electrodes...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27743319/lipopolysaccharide-and-curcumin-co-stimulation-potentiates-olfactory-ensheathing-cell-phagocytosis-via-enhancing-their-activation
#9
Ding-Jun Hao, Cuicui Liu, Lingling Zhang, Bo Chen, Qian Zhang, Rui Zhang, Jing An, Jingjing Zhao, Mingmei Wu, Yi Wang, Alfred Simental, Baorong He, Hao Yang
The gradual deterioration following central nervous system (CNS) injuries or neurodegenerative disorders is usually accompanied by infiltration of degenerated and apoptotic neural tissue debris. A rapid and efficient clearance of these deteriorated cell products is of pivotal importance in creating a permissive environment for regeneration of those damaged neurons. Our recent report revealed that the phagocytic activity of olfactory ensheathing cells (OECs) can make a substantial contribution to neuronal growth in such a hostile environment...
October 14, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27718014/common-olfactory-ensheathing-glial-markers-in-the-developing-human-olfactory-system
#10
Karen Oprych, Daniel Cotfas, David Choi
The in situ immunocytochemical properties of olfactory ensheathing cells (OECs) have been well studied in several small to medium sized animal models including rats, mice, guinea pigs, cats and canines. However, we know very little about the antigenic characteristics of OECs in situ within the adult and developing human olfactory bulb and nerve roots. To address this gap in knowledge we undertook an immunocytochemical analysis of the 11-19 pcw human foetal olfactory system. Human foetal OECs in situ possessed important differences compared to rodents in the expression of key surface markers...
October 7, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27641994/olfactory-ensheathing-glia-cell-therapy-and-tubular-conduit-enhance-nerve-regeneration-after-mouse-sciatic-nerve-transection
#11
Camila Oliveira Goulart, Daniella de Freitas Pereira Ângelo Durço, Lítia Alves de Carvalho, Júlia Teixeira Oliveira, Lucinéia Alves, Leny A Cavalcante, Ana Maria Blanco Martinez
The regenerative potential of the peripheral nervous system (PNS) is widely known, but functional recovery, particularly in humans, is seldom complete. Therefore, it is necessary to resort to strategies that induce or potentiate the PNS regeneration. Our main objective was to test the effectiveness of Olfactory Ensheathing Cells (OEC) transplantation into a biodegradable conduit as a therapeutic strategy to improve the repair outcome after nerve injury. Sciatic nerve transection was performed in C57BL/6 mice; proximal and distal stumps of the nerve were sutured into the collagen conduit...
November 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27574816/olfactory-ensheathing-cells-but-not-fibroblasts-reduce-the-duration-of-autonomic-dysreflexia-in-spinal-cord-injured-rats
#12
Frank Cloutier, Tomas Kalincik, Jenny Lauschke, Gervase Tuxworth, Brenton Cavanagh, Adrian Meediniya, Alan Mackay-Sim, Pascal Carrive, Phil Waite
Autonomic dysreflexia is a common complication after high level spinal cord injury and can be life-threatening. We have previously shown that the acute transplantation of olfactory ensheathing cells into the lesion site of rats transected at the fourth thoracic spinal cord level reduced autonomic dysreflexia up to 8weeks after spinal cord injury. This beneficial effect was correlated with changes in the morphology of sympathetic preganglionic neurons despite the olfactory cells surviving no longer than 3weeks...
August 24, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27535874/sulfatase-mediated-manipulation-of-the-astrocyte-schwann-cell-interface
#13
Paul O'Neill, Susan L Lindsay, Andreea Pantiru, Scott E Guimond, Nitish Fagoe, Joost Verhaagen, Jeremy E Turnbull, John S Riddell, Susan C Barnett
Schwann cell (SC) transplantation following spinal cord injury (SCI) may have therapeutic potential. Functional recovery is limited however, due to poor SC interactions with host astrocytes and the induction of astrogliosis. Olfactory ensheathing cells (OECs) are closely related to SCs, but intermix more readily with astrocytes in culture and induce less astrogliosis. We previously demonstrated that OECs express higher levels of sulfatases, enzymes that remove 6-O-sulfate groups from heparan sulphate proteoglycans, than SCs and that RNAi knockdown of sulfatase prevented OEC-astrocyte mixing in vitro...
August 18, 2016: Glia
https://www.readbyqxmd.com/read/27534509/brain-derived-neurotrophic-factor-promotes-the-migration-of-olfactory-ensheathing-cells-through-trpc-channels
#14
Ying Wang, Hong-Lin Teng, Yuan Gao, Fan Zhang, Yu-Qiang Ding, Zhi-Hui Huang
Olfactory ensheathing cells (OECs) are a unique type of glial cells with axonal growth-promoting properties in the olfactory system. Organized migration of OECs is essential for neural regeneration and olfactory development. However, the molecular mechanism of OEC migration remains unclear. In the present study, we examined the effects of brain-derived neurotrophic factor (BDNF) on OEC migration. Initially, the "scratch" migration assay, the inverted coverslip and Boyden chamber migration assays showed that BDNF could promote the migration of primary cultured OECs...
August 18, 2016: Glia
https://www.readbyqxmd.com/read/27505621/combination-of-a-peptide-modified-gellan-gum-hydrogel-with-cell-therapy-in-a-lumbar-spinal-cord-injury-animal-model
#15
Eduardo D Gomes, Sofia S Mendes, Hugo Leite-Almeida, Jeffrey M Gimble, Roger Y Tam, Molly S Shoichet, Nuno Sousa, Nuno A Silva, António J Salgado
Spinal Cord Injury (SCI) is a highly incapacitating condition for which there is still no cure. Current clinical approaches are mainly based on palliative care, so there is a need to find possible treatments to SCI. Cellular transplantation is regarded with great expectation due to the therapeutic potential of cells such as Adipose tissue-derived Stromal/Stem Cells (ASCs) or Olfactory Ensheathing Cells (OECs). Both are accessible sources and present positive paracrine and cell-to-cell interactions, previously reported by our group...
October 2016: Biomaterials
https://www.readbyqxmd.com/read/27491233/-brain-protection-of-muscone-in-rats-with-brain-injury
#16
Tao Jiang, Li-fa Huang, Shui-jing Zhou, Jian-jun Cui, Qiang Ye
OBJECTIVE: To observe cerebral protective effect of muscone (nasal administration) on traumatic brain injury model rats. METHODS: SD rats were divided into the sham-operation group, the model group, and the treatment groups according to random digit table, 50 in each group. Traumatic brain injury model was established by controlled cortical strike. Rats in the sham-operation group received surgery and anesthesia procedures only, with no strike. Muscone (1.8 mg/kg) was delivered to rats in the treatment group using in situ nasal perfusion, 30 min each time, twice daily for 7 successive days...
June 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/27423610/canine-olfactory-ensheathing-cells-from-the-olfactory-mucosa-can-be-engineered-to-produce-active-chondroitinase-abc
#17
Darren Carwardine, Liang-Fong Wong, James W Fawcett, Elizabeth M Muir, Nicolas Granger
A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an overall improvement in function. Chondroitin sulphate proteoglycans (CSPGs) present in the glial scar that forms following SCI present a significant block to axon regeneration. Digestion of CSPGs by chondroitinase ABC (ChABC) leads to axon regeneration, neuronal plasticity and functional improvement in preclinical models of SCI...
August 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27387270/a-lab-on-a-chip-device-for-investigating-the-fusion-process-of-olfactory-ensheathing-cell-spheroids
#18
Ahmed Munaz, Raja K Vadivelu, James A St John, Nam-Trung Nguyen
Understanding the process of fusion of olfactory ensheathing cell spheroids will lead to improvement of cell transplantation therapies to repair spinal cord injuries. The successful fusion of transplanted spheroids will enable alternative transplantation strategies to be developed for in vivo applications. This paper describes the use of a microfluidic device to trap and fuse olfactory ensheathing cell spheroids. The velocity, the pressure distribution in the device were simulated numerically to predict the trapping location...
August 7, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27343824/linckosides-enhance-proliferation-and-induce-morphological-changes-in-human-olfactory-ensheathing-cells
#19
Johana Tello Velasquez, Rebecca-Qing Yao, Filip Lim, Chunguang Han, Makoto Ojika, Jenny A K Ekberg, Ronald J Quinn, James A St John
Linckosides are members of the steroid glycoside family isolated from the starfish Linckia laevigata. These natural compounds have notable neuritogenic activity and synergistic effects on NGF-induced neuronal differentiation of PC12 cells. Neurogenic factors or molecules that are able to mimic their activities are known to be involved in the survival, proliferation and migration of neurons and glial cells; however how glial cells respond to specific neurogenic molecules such as linckosides has not been investigated...
September 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27277804/olfactory-ensheathing-cell-transplantation-after-a-complete-spinal-cord-transection-mediates-neuroprotective-and-immunomodulatory-mechanisms-to-facilitate-regeneration
#20
Rana R Khankan, Khris G Griffis, James R Haggerty-Skeans, Hui Zhong, Roland R Roy, V Reggie Edgerton, Patricia E Phelps
UNLABELLED: Multiple neural and peripheral cell types rapidly respond to tissue damage after spinal cord injury to form a structurally and chemically inhibitory scar that limits axon regeneration. Astrocytes form an astroglial scar and produce chondroitin sulfate proteoglycans (CSPGs), activate microglia, and recruit blood-derived immune cells to the lesion for debris removal. One beneficial therapy, olfactory ensheathing cell (OEC) transplantation, results in functional improvements and promotes axon regeneration after spinal cord injury...
June 8, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
keyword
keyword
96484
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"