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Olfactory ensheathing cells

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https://www.readbyqxmd.com/read/29150616/nmr-metabolomics-for-stem-cell-type-discrimination
#1
Franca Castiglione, Monica Ferro, Evangelos Mavroudakis, Rosalia Pellitteri, Patrizia Bossolasco, Damiano Zaccheo, Massimo Morbidelli, Vincenzo Silani, Andrea Mele, Davide Moscatelli, Lidia Cova
Cell metabolism is a key determinant factor for the pluripotency and fate commitment of Stem Cells (SCs) during development, ageing, pathological onset and progression. We derived and cultured selected subpopulations of rodent fetal, postnatal, adult Neural SCs (NSCs) and postnatal glial progenitors, Olfactory Ensheathing Cells (OECs), respectively from the subventricular zone (SVZ) and the olfactory bulb (OB). Cell lysates were analyzed by proton Nuclear Magnetic Resonance ((1)H-NMR) spectroscopy leading to metabolites identification and quantitation...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29094304/perineuronal-nets-labeled-by-monoclonal-antibody-vc1-1-ensheath-interneurons-expressing-parvalbumin-and-calbindin-in-the-rat-amygdala
#2
Alexander J McDonald, Patricia G Hamilton, Colin J Barnstable
Perineuronal nets (PNNs) are specialized condensations of extracellular matrix that ensheath particular neuronal subpopulations in the brain and spinal cord. PNNs regulate synaptic plasticity, including the encoding of fear memories by the amygdala. The present immunohistochemical investigation studied PNN structure and distribution, as well as the neurochemistry of their ensheathed neurons, in the rat amygdala using monoclonal antibody VC1.1, which recognizes a glucuronic acid 3-sulfate glycan associated with PNNs in the cerebral cortex...
November 1, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28973792/rostro-caudal-maturation-of-glial-cells-in-the-accessory-olfactory-system-during-development-involvement-in-outgrowth-of-gnrh-neurites
#3
Sarah Geller, Didier Lomet, Alain Caraty, Yves Tillet, Anne Duittoz, Pascal Vaudin
During mammalian embryonic development, GnRH neurones differentiate from the nasal placode and migrate through the nasal septum towards the forebrain. We previously showed that a category of glial cells, the olfactory ensheathing cells (OEC), forms the microenvironment of migrating GnRH neurones. Here, to characterize the quantitative and qualitative importance of this glial, we investigated the spatiotemporal maturation of glial cells in situ and the role of maturing glia in GnRH neurones development ex vivo...
October 3, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28966235/ginsenoside-rg1-promotes-the-migration-of-olfactory-ensheathing-cells-via-the-pi3k-akt-pathway-to-repair-rat-spinal-cord-injury
#4
Yin-Yao Tang, Wei-Xiao Guo, Zheng-Feng Lu, Mao-Hua Cheng, Yi-Xin Shen, Ying-Zi Zhang
The aim of this study was to determine the effects of ginsenoside Rg1 on the migration of olfactory ensheathing cells (OECs) in vitro, and its influence on the therapeutic efficacy of OECs transplanted in vivo for the treatment of spinal cord injury (SCI). Primary cultured and purified OECs (prepared from rats) were treated with ginsenoside Rg1. The wound healing test indicated that ginsenoside Rg1 promoted the migration of OECs. Real-time RT-PCR demonstrated that ginsenoside Rg1 upregulated the expression of migration-related factors of OECs, including matrix metalloproteinases-2 (MMP-2), MMP-9, and neural cell adhesion molecule 1 (NCAM1)...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28901191/hypoxic-culture-promotes-dopaminergic-neuronal-differentiation-of-nasal-olfactory-mucosa-mesenchymal-stem-cells-via-upregulation-of-hypoxia-inducible-factor-1%C3%AE
#5
Yi Zhuo, Lei Wang, Lite Ge, Xuan Li, Da Duan, Xiaohua Teng, Miao Jiang, Kai Liu, Ting Yuan, Pei Wu, Hao Wang, Yujia Deng, Huali Xie, Ping Chen, Ying Xia, Ming Lu
Olfactory mucosa mesenchymal stem cells (OM-MSCs) display significant clonogenic activity and may be easily propagated for Parkinson's disease therapies. Methods of inducing OM-MSCs to differentiate into dopaminergic (DAergic) neurons using olfactory ensheathing cells (OECs) are thus an attractive topic of research. We designed a hypoxic induction protocol to generate DAergic neurons from OM-MSCs using a physiological oxygen (O2) level of 3% and OEC-conditioned medium (OCM; HI group). The normal induction (NI) group was cultured in O2 at ambient air level (21%)...
August 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28899479/olfactory-ensheathing-cell-tumor-a-case-presentation
#6
Michael H Schild, William T Harrison, Thomas J Cummings
No abstract text is available yet for this article.
September 7, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28860093/tgf-%C3%AE-1-enhances-phagocytic-removal-of-neuron-debris-and-neuronal-survival-by-olfactory-ensheathing-cells-via-integrin-mfg-e8-signaling-pathway
#7
Yijian Li, Ting Zou, Langyue Xue, Zheng Qin Yin, Shujia Huo, Haiwei Xu
Olfactory ensheathing cells (OECs) have been shown to be a leading candidate in cell therapies for central nervous system (CNS) injuries and neurodegenerative diseases. Rapid clearance of neuron debris can promote neuronal survival and axonal regeneration in CNS injuries and neurodegenerative diseases. The phagocytic removal of neuron debris by OECs has been shown to contribute to neuronal outgrowth. However, the precise molecular and cellular mechanisms of phagocytic removal of neuron debris by OECs have not been explored...
August 30, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28843247/corrigendum-to-subarachnoid-space-transplantation-of-schwann-and-or-olfactory-ensheathing-cells-following-severe-spinal-cord-injury-fails-to-improve-locomotor-recovery-in-rats-acta-med-iran-2016-54-9-562-569
#8
Mohsen Nategh, Masoumeh Firouzi, Mehdi Naji-Tehrani, Leila Oryadi Zanjani, Zahra Hassannejad, Mohammad Hosein Nabian, Shayan Abdollah Zadegan, Mehrbod Karimi, Vafa Rahimi-Movaghar
No abstract text is available yet for this article.
June 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28761411/the-crossed-phrenic-phenomenon
#9
REVIEW
Michael George Zaki Ghali
The cervical spine is the most common site of traumatic vertebral column injuries. Respiratory insufficiency constitutes a significant proportion of the morbidity burden and is the most common cause of mortality in these patients. In seeking to enhance our capacity to treat specifically the respiratory dysfunction following spinal cord injury, investigators have studied the "crossed phrenic phenomenon", wherein contraction of a hemidiaphragm paralyzed by a complete hemisection of the ipsilateral cervical spinal cord above the phrenic nucleus can be induced by respiratory stressors and recovers spontaneously over time...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28698720/corrigendum-to-therapeutic-potential-of-olfactory-ensheathing-cells-and-mesenchymal-stem-cells-in-spinal-cord-injuries
#10
Anna Zadroga, Katarzyna Jezierska-Woźniak, Joanna Czarzasta, Monika Barczewska, Joanna Wojtkiewicz, Wojciech Maksymowicz
[This corrects the article DOI: 10.1155/2017/3978595.].
2017: Stem Cells International
https://www.readbyqxmd.com/read/28680155/polarized-distribution-of-active-myosin-ii-regulates-directional-migration-of-cultured-olfactory-ensheathing-cells
#11
Cheng-Gen Zheng, Fan Zhang, Xiao-Mei Bao, Shi-Yang Wu, Peng Wang, Jia-Nan Zhou, Yuan Gao, Hong-Lin Teng, Ying Wang, Zhi-Hui Huang
Migration of olfactory ensheathing cells (OECs) is critical for development of olfactory system and essential for neural regeneration after OEC transplantation into nerve injury site. However, the molecular mechanisms underlying the regulation of directional migration of OECs remain unclear. In this study, we found that in migrating OECs, phosphorylated myosin light chain (p-MLC, active myosin II) displayed a polarized distribution, with the leading front exhibiting higher than soma and trailing process. Over-expression of GFP-MLC significantly reduced OEC migration...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674010/fibroblast-growth-factor-signaling-instructs-ensheathing-glia-wrapping-of-drosophila-olfactory-glomeruli
#12
Bing Wu, Jiefu Li, Ya-Hui Chou, David Luginbuhl, Liqun Luo
The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in the antennal lobe, each of which represents a discrete olfactory information-processing channel. Each compartment is separated from the adjacent compartments by membranous processes from ensheathing glia. Here we show that Thisbe, an FGF released from olfactory neurons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus...
July 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28656221/effect-of-transplantation-of-olfactory-ensheathing-cell-conditioned-medium-induced-bone-marrow-stromal-cells-on-rats-with-spinal-cord-injury
#13
Linjie Feng, Hongquan Gan, Wenguo Zhao, Yingjie Liu
Spinal cord injury is a serious threat to human health and various techniques have been deployed to ameliorate or cure its effects. Stem cells transplantation is one of the promising methods. The primary aim of the present study was to investigate the effect of the transplantation of olfactory ensheathing cell (OEC) conditioned medium‑induced bone marrow stromal cells (BMSCs) on spinal cord injury. Rat spinal cord compression injury animal models were generated, and the rats divided into the following three groups: Group A, (control) Dulbecco's modified Eagle's medium‑treated group; group B, normal BMSC‑treated group; group C, OEC conditioned medium‑induced BMSC‑treated group...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28623671/feasibility-of-diffusion-tensor-imaging-for-assessing-functional-recovery-in-rats-with-olfactory-ensheathing-cell-transplantation-after-contusive-spinal-cord-injury-sci
#14
Mengchao Gu, Zhengchao Gao, Xiaohui Li, Feng Zhao, Lei Guo, Jiantao Liu, Xijing He
BACKGROUND Olfactory ensheathing cell transplantation is a promising treatment for spinal cord injury. Diffusion tensor imaging has been applied to assess various kinds of spinal cord injury. However, it has rarely been used to evaluate the beneficial effects of olfactory ensheathing cell transplantation. This study aimed to explore the feasibility of diffusion tensor imaging in the evaluation of functional recovery in rats with olfactory ensheathing cell transplantation after contusive spinal cord injury. MATERIAL AND METHODS Immunofluorescence staining was performed to determine the purity of olfactory ensheathing cells...
June 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28613324/a-fusion-of-minicircle-dna-and-nanoparticle-delivery-technologies-facilitates-therapeutic-genetic-engineering-of-autologous-canine-olfactory-mucosal-cells
#15
Alexander M Delaney, Christopher F Adams, Alinda R Fernandes, Arwa F Al-Shakli, Jon Sen, Darren R Carwardine, Nicolas Granger, Divya M Chari
Olfactory ensheathing cells (OECs) promote axonal regeneration and improve locomotor function when transplanted into the injured spinal cord. A recent clinical trial demonstrated improved motor function in domestic dogs with spinal injury following autologous OEC transplantation. Their utility in canines offers promise for human translation, as dogs are comparable to humans in terms of clinical management and genetic/environmental variation. Moreover, the autologous, minimally invasive derivation of OECs makes them viable for human spinal injury investigation...
June 29, 2017: Nanoscale
https://www.readbyqxmd.com/read/28575969/li-activated-nanohydroxyapatite-doped-with-eu-3-ions-enhances-proliferative-activity-and-viability-of-human-stem-progenitor-cells-of-adipose-tissue-and-olfactory-ensheathing-cells-further-perspective-of-nhap-li-eu-3-application-in-theranostics
#16
Krzysztof Marycz, Paulina Sobierajska, Agnieszka Smieszek, Monika Maredziak, Katarzyna Wiglusz, Rafal J Wiglusz
Spinal cord injuries (SCI) often require simultaneous regeneration of nerve tissue and bone. Hydroxyapatites are described as bioresorbable materials with proper biocompatibility and osteoconductivity, therefore its application for spinal surgery is considered. In this paper, we present repeatable method for developing nanocrystalline calcium hydroxyapatites structurally modified with Li(+) ions (nHAP:Li(+)). Obtained biomaterials were profoundly characterized in terms of their physicochemical properties. Moreover, we have shown that nHAP:Li(+) doped with europium (Eu(3+)) may serve as a theranostic agent, what additionally extend its potential usage for SCI treatment...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28545516/improving-the-regenerative-potential-of-olfactory-ensheathing-cells-by-overexpressing-prostacyclin-synthetase-and-its-application-in-spinal-cord-repair
#17
May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang, Henrich Cheng
BACKGROUND: Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration. Grafting OEC to injured spinal cord appears to facilitate axonal regeneration although the functional recovery is limited. In an attempt to improve the growth-promoting properties of OEC, we transduced prostacyclin synthase (PGIS) to OEC via adenoviral (Ad) gene transfer and examined the effect of OEC with enhanced prostacyclin synthesis in co-culture and in vivo...
May 25, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28497341/chronic-tnf%C3%AE-exposure-induces-robust-proliferation-of-olfactory-ensheathing-cells-but-not-schwann-cells
#18
Karen L Lankford, Edgardo J Arroyo, Jeffery D Kocsis
TNFα is persistently elevated in many injury and disease conditions. Previous reports of cytotoxicity of TNFα for oligodendrocytes and their progenitors suggest that the poor endogenous remyelination in patients with traumatic injury or multiple sclerosis may be due in part to persistent inflammation. Understanding the effects of inflammatory cytokines on potential cell therapy candidates is therefore important for evaluating the feasibility of their use. In this study, we assessed the effects of long term exposure to TNFα on viability, proliferation, migration and TNFα receptor expression of cultured rat olfactory ensheathing cells (OECs) and Schwann cells (SCs)...
September 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28488330/inhibition-of-cx43-mediates-protective-effects-on-hypoxic-reoxygenated-human-neuroblastoma-cells
#19
Nunzio Vicario, Giovanna Calabrese, Agata Zappalà, Carmela Parenti, Stefano Forte, Adriana Carol Eleonora Graziano, Luca Vanella, Rosalia Pellitteri, Venera Cardile, Rosalba Parenti
Olfactory ensheathing cells (OECs), a special population of glial cells, are able to synthesise several trophic factors exerting a neuroprotective action and promoting growth and functional recovery in both in vitro and in vivo models. In the present work, we investigated the neuroprotective effects of OEC-conditioned medium (OEC-CM) on two different human neuron-like cell lines, SH-SY5Y and SK-N-SH (neuroblastoma cell lines), under normoxic and hypoxic conditions. In addition, we also focused our attention on the role of connexins (Cxs) in the neuroprotective processes...
October 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28461136/olfactory-ensheathing-cell-transplantation-inhibits-p2x4-receptor-overexpression-in-spinal-cord-injury-rats-with-neuropathic-pain
#20
Zuncheng Zheng, Xiaojing Du, Kaigang Zhang, Xiaoyu Wang, Yuexia Chen, Naifeng Kuang, Tao Fan, Baoliang Sun
Cell-based therapy is a promising strategy to alleviate neuropathic pain caused by spinal cord injury (SCI). We transplanted olfactory ensheathing cells (OECs) into SCI rats with neuropathic pain and quantitatively detected the sensory nerve function. The expression levels of P2X4 receptor (P2X4R), 200kD neurofilament heavy polypeptide (NF200), and glial fiber acidic protein (GFAP) were measured by immunofluorescence and Western blot analyses. Results showed that NF200 expression significantly increased, GFAP expression decreased, and sensory nerve function improved...
April 28, 2017: Neuroscience Letters
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