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https://www.readbyqxmd.com/read/28092515/towards-a-run-to-run-adaptive-artificial-pancreas-in-silico-results
#1
Chiara Toffanin, Roberto Visentin, Mirko Messori, Federico Di Palma, Lalo Magni, Claudio Cobelli
: Contemporary and future outpatient long-term artificial pancreas (AP) studies need to cope with the well-known large intra- and inter-day glucose variability occurring in type 1 diabetic (T1D) subjects. Here we propose an adaptive Model Predictive Control (MPC) strategy to account for it and test it in silico. METHODS: A Run-to-Run (R2R) approach adapts the subcutaneous basal insulin delivery during the night and the carbohydrate-to-insulin ratio (CR) during the day, based on some performance indices calculated from subcutaneous continuous glucose sensor data...
January 11, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28067533/frequent-coexistence-of-chronic-heart-failure-and-chronic-obstructive-pulmonary-disease-in-respiratory-and-cardiac-outpatients-evidence-from-suspirium-a-multicentre-italian-survey
#2
Raffaele Griffo, Antonio Spanevello, Pier Luigi Temporelli, Pompilio Faggiano, Mauro Carone, Giovanna Magni, Nicolino Ambrosino, Luigi Tavazzi
Background Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) frequently coexist but concurrent COPD + CHF has been little investigated. Design This multicentre survey (SUSPIRIUM) was designed to evaluate: the prevalence of COPD in stable CHF and CHF in stable COPD; diagnostic/therapeutic work-up for concurrent COPD + CHF; clinical profile of patients with COPD + CHF; predictors of COPD in CHF and CHF in COPD. Methods A 5-month-long cross-sectional prospective observational survey was conducted in 10 cardiac and 10 respiratory connected outpatient units...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28009426/-christmas-balls-a-christmas-carol-by-the-adolescent-cancer-patients-of-the-milan-youth-project
#3
Andrea Ferrari, Stefano Signoroni, Matteo Silva, Paola Gaggiotti, Laura Veneroni, Chiara Magni, Michela Casanova, Stefano Chiaravalli, Mirko Capelletti, Pietro Lapidari, Carlo Alfredo Clerici, Maura Massimino
The Youth Project is a program developed at the Pediatric Oncology Unit at the Istituto Nazionale Tumori in Milan, dedicated to adolescents and young adults with cancer. Among its various goals, the Youth Project organizes structured creative activities with the support of professionals, with the objective of offering young people a new way to express their hopes and fears. This article describes a project centered around music: patients created a Christmas carol with the help of musicians and authors. The adolescents explained with their own words the meaning of the lyrics, telling the story of a Christmas spent in a cancer hospital ward...
December 19, 2016: Tumori
https://www.readbyqxmd.com/read/27993144/disease-status-reasons-for-discontinuation-and-adverse-events-in-1038-italian-children-with-juvenile-idiopathic-arthritis-treated-with-etanercept
#4
Sara Verazza, Sergio Davì, Alessandro Consolaro, Francesca Bovis, Antonella Insalaco, Silvia Magni-Manzoni, Rebecca Nicolai, Denise Pires Marafon, Fabrizio De Benedetti, Valeria Gerloni, Irene Pontikaki, Francesca Rovelli, Rolando Cimaz, Achille Marino, Francesco Zulian, Giorgia Martini, Serena Pastore, Chiara Sandrin, Fabrizia Corona, Marta Torcoletti, Giovanni Conti, Claudia Fede, Patrizia Barone, Marco Cattalini, Elisabetta Cortis, Luciana Breda, Alma Nunzia Olivieri, Adele Civino, Rosanna Podda, Donato Rigante, Francesco La Torre, Gianfranco D'Angelo, Mauro Jorini, Romina Gallizzi, Maria Cristina Maggio, Rita Consolini, Alessandro De Fanti, Valentina Muratore, Maria Giannina Alpigiani, Nicolino Ruperto, Alberto Martini, Angelo Ravelli
BACKGROUND: Data from routine clinical practice are needed to further define the efficacy and safety of biologic medications in children with juvenile idiopathic arthritis (JIA). The aim of this analysis was to investigate the disease status, reasons for discontinuation and adverse events in Italian JIA patients treated with etanercept (ETN). METHODS: In 2013, all centers of the Italian Pediatric Rheumatology Study Group were asked to make a census of patients given ETN after January 2000...
December 20, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27974060/contribution-of-binge-eating-behaviour-to-cardiometabolic-risk-factors-in-subjects-starting-a-weight-loss-or-maintenance-programme
#5
Alessandro Leone, Giorgio Bedogni, Veronica Ponissi, Alberto Battezzati, Valentina Beggio, Paolo Magni, Massimiliano Ruscica, Simona Bertoli
The contribution of binge eating (BE) behaviour to cardiometabolic risk factors has been scarcely investigated so far. Previous studies have not considered the nutritional status and lifestyle of subjects suffering from BE. The aim of this study was to evaluate the contribution of BE to the metabolic syndrome (MS), its components, high total cholesterol and high LDL in a large sample of subjects, taking into account nutritional status, dietary habits, smoking status and physical activity. For this purpose, 5175 adults seeking a weight loss or maintenance programme were recruited...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27939607/proteomic-profiles-of-thyroid-tumors-by-mass-spectrometry-imaging-on-tissue-microarrays
#6
Manuel Galli, Fabio Pagni, Gabriele De Sio, Andrew Smith, Clizia Chinello, Martina Stella, Vincenzo L'Imperio, Marco Manzoni, Mattia Garancini, Diego Massimini, Niccolò Mosele, Giancarlo Mauri, Italo Zoppis, Fulvio Magni
The current study proposes the successful use of a mass spectrometry-imaging technology that explores the composition of biomolecules and their spatial distribution directly on-tissue to differentially classify benign and malignant cases, as well as different histotypes. To identify new specific markers, we investigated with this technology a wide histological Tissue Microarray (TMA)-based thyroid lesion series. Results showed specific protein signatures for malignant and benign specimens and allowed to build clusters comprising several proteins with discriminant capabilities...
December 9, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27931834/treatments-for-colorectal-liver-metastases-a-new-focus-on-a-familiar-concept
#7
REVIEW
M G Zampino, E Magni, P S Ravenda, C A Cella, G Bonomo, P Della Vigna, S Galdy, F Spada, G M Varano, G Mauri, N Fazio, F Orsi
A major challenge for the management of advanced-colorectal-cancer is the multidisciplinary approach required for the treatment of liver metastases. Reducing the burden of liver metastases with liver-directed therapy has an important impact on both survival and health-related quality of life. This paper debates the rationale and current liver-directed approaches for colorectal liver metastases based on the evidence of literature and new clinical trials. Surgery is the gold standard, when feasible, and it's the main treatment goal for patients with potentially-resectable disease as a means of prolonging progression-free survival...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27921860/effects-of-cognitive-remediation-therapy-on-neurocognition-and-negative-symptoms-in-schizophrenia-an-italian-naturalistic-study
#8
Mariangela Lanfredi, Giacomo Deste, Clarissa Ferrari, Stefano Barlati, Laura Rosa Magni, Roberta Rossi, Luca de Peri, Marco Bonomi, Giuseppe Rossi, Antonio Vita
INTRODUCTION: Cognitive remediation therapy (CRT) has been reported to positively affect neurocognitive processes among patients with schizophrenia; however, the degree to which changes in cognition is linked to improved clinical symptoms, remains poorly understood. The current study aimed to investigate whether cognitive gains were associated to improvements in negative symptoms' severity in patients with schizophrenia living in two Italian psychiatric facilities. METHODS: Patients with a diagnosis of schizophrenia were consecutively assigned to CRT (n = 33) and compared with an historical control group (n = 28)...
December 6, 2016: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/27890680/the-putative-role-of-maldi-msi-in-the-study-of-membranous-nephropathy
#9
Andrew Smith, Vincenzo L'Imperio, Elena Ajello, Franco Ferrario, Niccolò Mosele, Martina Stella, Manuel Galli, Clizia Chinello, Federico Pieruzzi, Goce Spasovski, Fabio Pagni, Fulvio Magni
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents the leading cause of nephrotic syndrome in adults and is one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate management of patients. In secondary cases, the best strategy consists in treating the underlying disease whereas in primary forms, the possible identification of confirmatory markers of the idiopathic etiology underlining the process is requested by clinicians...
November 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27886122/remote-blood-glucose-monitoring-in-mhealth-scenarios-a-review
#10
Giordano Lanzola, Eleonora Losiouk, Simone Del Favero, Andrea Facchinetti, Alfonso Galderisi, Silvana Quaglini, Lalo Magni, Claudio Cobelli
Glucose concentration in the blood stream is a critical vital parameter and an effective monitoring of this quantity is crucial for diabetes treatment and intensive care management. Effective bio-sensing technology and advanced signal processing are therefore of unquestioned importance for blood glucose monitoring. Nevertheless, collecting measurements only represents part of the process as another critical task involves delivering the collected measures to the treating specialists and caregivers. These include the clinical staff, the patient's significant other, his/her family members, and many other actors helping with the patient treatment that may be located far away from him/her...
November 24, 2016: Sensors
https://www.readbyqxmd.com/read/27856846/seasonal-exposure-of-carbon-dioxide-ice-on-the-nucleus-of-comet-67p-churyumov-gerasimenko
#11
G Filacchione, A Raponi, F Capaccioni, M Ciarniello, F Tosi, M T Capria, M C De Sanctis, A Migliorini, G Piccioni, P Cerroni, M A Barucci, S Fornasier, B Schmitt, E Quirico, S Erard, D Bockelee-Morvan, C Leyrat, G Arnold, V Mennella, E Ammannito, G Bellucci, J Benkhoff, J P Bibring, A Blanco, M I Blecka, R Carlson, U Carsenty, L Colangeli, M Combes, M Combi, J Crovisier, P Drossart, T Encrenaz, C Federico, U Fink, S Fonti, M Fulchignoni, W-H Ip, P Irwin, R Jaumann, E Kuehrt, Y Langevin, G Magni, T McCord, L Moroz, S Mottola, E Palomba, U Schade, K Stephan, F Taylor, D Tiphene, G P Tozzi, P Beck, N Biver, L Bonal, J-Ph Combe, D Despan, E Flamini, M Formisano, A Frigeri, D Grassi, M S Gudipati, D Kappel, A Longobardo, F Mancarella, K Markus, F Merlin, R Orosei, G Rinaldi, M Cartacci, A Cicchetti, Y Hello, F Henry, S Jacquinod, J M Reess, R Noschese, R Politi, G Peter
Carbon dioxide (CO2) is one of the most abundant species in cometary nuclei, but because of its high volatility, CO2 ice is generally only found beneath the surface. We report the infrared spectroscopic identification of a CO2 ice-rich surface area located in the Anhur region of comet 67P/Churyumov-Gerasimenko. Spectral modeling shows that about 0.1% of the 80- by 60-meter area is CO2 ice. This exposed ice was observed a short time after the comet exited local winter; following the increased illumination, the CO2 ice completely disappeared over about 3 weeks...
December 23, 2016: Science
https://www.readbyqxmd.com/read/27852685/evaluating-the-experience-of-children-with-type-1-diabetes-and-their-parents-taking-part-in-an-artificial-pancreas-clinical-trial-over-multiple-days-in-a-diabetes-camp-setting
#12
Alda Troncone, Riccardo Bonfanti, Dario Iafusco, Ivana Rabbone, Alberto Sabbion, Riccardo Schiaffini, Alfonso Galderisi, Marco Marigliano, Novella Rapini, Andrea Rigamonti, Davide Tinti, Valeria Vallone, Angela Zanfardino, Federico Boscari, Simone Del Favero, Silvia Galasso, Giordano Lanzola, Mirko Messori, Federico Di Palma, Roberto Visentin, Roberta Calore, Yenny Leal, Lalo Magni, Eleonora Losiouk, Daniel Chernavvsky, Silvana Quaglini, Claudio Cobelli, Daniela Bruttomesso
OBJECTIVE: To explore the experiences of children with type 1 diabetes and their parents taking part in an artificial pancreas (AP) clinical trial during a 7-day summer camp. RESEARCH DESIGN AND METHODS: A semistructured interview, composed of 14 questions based on the Technology Acceptance Model, was conducted at the end of the clinical trial. Participants also completed the Diabetes Treatment Satisfaction Questionnaire (DTSQ, parent version) and the AP Acceptance Questionnaire...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27816627/pharmacokinetic-pharmacodynamic-modeling-of-etoposide-tumor-growth-inhibitory-effect-in-walker-256-tumor-bearing-rat-model-using-free-intratumoral-drug-concentrations
#13
Maiara Cássia Pigatto, Renatha Menti Roman, Letizia Carrara, Andréia Buffon, Paolo Magni, Teresa Dalla Costa
The purpose of this study was to establish a population pharmacokinetic/pharmacodynamic (PK/PD) model linking etoposide free tumor and total plasma concentrations to the inhibition of solid tumor growth in rats. Walker-256 tumor cells were inoculated subcutaneously in the right flank of Wistar rats, which were randomly divided in control and two treated groups that received etoposide 5 or 10mg/kg i.v. bolus every day for 8 and 4days, respectively, and tumor volume was monitored daily for 30days. The plasma and intratumoral concentrations-time profiles were obtained from a previous study and were modeled by a four-compartment population pharmacokinetic (popPK) model...
January 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27809498/theranostic-nanocages-for-imaging-and-photothermal-therapy-of-prostate-cancer-cells-by-active-targeting-of-neuropeptide-y-receptor
#14
Svetlana Avvakumova, Elisabetta Galbiati, Laura Sironi, Silvia A Locarno, Luca Gambini, Chiara Macchi, Laura Pandolfi, Massimiliano Ruscica, Paolo Magni, Maddalena Collini, Miriam Colombo, Fabio Corsi, Giuseppe Chirico, Sergio Romeo, Davide Prosperi
Gold nanocages (AuNCs) have been shown to be a useful tool for harnessing imaging and hyperthermia therapy of cancer, thanks to their unique optical properties, low toxicity, and facile surface functionalization. Herein, we use AuNCs for selective targeting of prostate cancer cells (PC3) via specific interaction between neuropeptide Y (NPY) receptor and three different NPY analogs conjugated to AuNCs. Localized surface plasmon resonance band of the nanoconjugates was set around 800 nm, which is appropriate for in vivo applications...
December 21, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27809307/a-novel-crosstalk-between-ccar2-and-akt-pathway-in-the-regulation-of-cancer-cell-proliferation
#15
Michela Restelli, Martina Magni, Vincenzo Ruscica, Patrizia Pinciroli, Loris De Cecco, Giacomo Buscemi, Domenico Delia, Laura Zannini
Human CCAR2 has recently emerged as having a pivotal role in the DNA damage response, promoting apoptosis and repair of heterochromatic DNA breaks. However, less is known about the function of CCAR2 in tumor formation and cancer progression. Here, we demonstrate, for the first time, that CCAR2 loss inhibits the proliferation of cancer cells, but preserves the growth of normal cells. Investigating the mechanisms responsible for this differential effect, we found that CCAR2 depletion specifically impairs the activation of AKT pathway in cancer cells, but not in normal cells, by reducing AKT phosphorylation on Ser473...
November 3, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27807491/comment-on-minilaparotomy-hysterectomy-as-a-suitable-choice-of-hysterectomy-for-large-myoma-uteri-literature-review
#16
COMMENT
Flavia Sorbi, Francesco Magni, Massimiliano Fambrini
No abstract text is available yet for this article.
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27770281/long-term-safety-of-growth-hormone-replacement-therapy-after-childhood-medulloblastoma-and-pnet-it-is-time-to-set-aside-old-concerns
#17
Alice Indini, Elisabetta Schiavello, Veronica Biassoni, Luca Bergamaschi, Maria Chiara Magni, Nadia Puma, Stefano Chiaravalli, Federica Pallotti, Ettore Seregni, Barbara Diletto, Emilia Pecori, Lorenza Gandola, Geraldina Poggi, Maura Massimino
To assess the long-term safety of administering growth hormone (GH) in patients with GH deficiency due to treatment for childhood medulloblastoma and primitive neuroectodermal tumor (PNET). Data were retrospectively retrieved on children receiving GH supplementation, assessing their disease-free and overall survival outcomes and risk of secondary malignancies using Kaplan-Meier and Cox models. Overall 65 children were consecutively collected from May 1981 to April 2013. All patients had undergone craniospinal irradiation (total dose 18-39 Gy), and subsequently received GH for a median (interquartile range, IQR) of 81 (50...
October 21, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27766412/reflectance-based-determination-of-age-and-species-of-blowfly-puparia
#18
Sasha C Voss, Paola Magni, Ian Dadour, Christian Nansen
Forensic entomology is primarily concerned with the estimation of time since death and involves determination of the age of immature insects colonising decomposing remains. Accurate age determination of puparia is usually accomplished by dissection, which means destructive sampling of evidence. As part of improving abilities to correctly identify species and developmental age, it is highly desirable to have available non-destructive methods. In this study, we acquired external hyperspectral imaging (HSI) data (77 spectral bands, 389-892 nm) from the dorsal and ventral sides of individual puparia of two species of blowfly (Diptera: Calliphoridae), Calliphora dubia Macquart 1855 and Chrysomya rufifacies Macquart 1842...
January 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27757595/effect-of-soy-on-metabolic-syndrome-and-cardiovascular-risk-factors-a-randomized-controlled-trial
#19
Massimiliano Ruscica, Chiara Pavanello, Sara Gandini, Monica Gomaraschi, Cecilia Vitali, Chiara Macchi, Beatrice Morlotti, Gilda Aiello, Raffaella Bosisio, Laura Calabresi, Anna Arnoldi, Cesare R Sirtori, Paolo Magni
BACKGROUND: Cardiovascular diseases are currently the commonest cause of death worldwide. Different strategies for their primary prevention have been planned, taking into account the main known risk factors, which include an atherogenic lipid profile and visceral fat excess. METHODS: The study was designed as a randomized, parallel, single-center study with a nutritional intervention duration of 12 weeks. Whole soy foods corresponding to 30 g/day soy protein were given in substitution of animal foods containing the same protein amount...
October 18, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27748142/the-proteomic-landscape-of-renal-tumors
#20
Clizia Chinello, Vincenzo L'imperio, Martina Stella, Andrew James Smith, Giorgio Bovo, Angelica Grasso, Marco Grasso, Francesca Raimondo, Marina Pitto, Fabio Pagni, Fulvio Magni
Renal cell carcinoma (RCC) is the most fatal of the common urologic cancers, with approximately 35% of patients dying within 5 years following diagnosis. Therefore, there is a need for non-invasive markers that are capable of detecting and determining the severity of small renal masses at an early stage in order to tailor treatment and follow-up. Proteomic studies have proved to be very useful in the study of tumors. Areas covered: In this review, we will detail the current knowledge obtained by the different proteomic approaches, focusing on MS-based strategies, used to investigate RCC biology in order to identify diagnostic, prognostic and predictive biomarkers on tissue, cultured cells and biological fluids...
October 28, 2016: Expert Review of Proteomics
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