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https://www.readbyqxmd.com/read/29029268/development-and-validation-of-a-method-for-the-detection-of-%C3%AE-and-%C3%AE-endosulfan-organochlorine-insecticide-in-calliphora-vomitoria-diptera-calliphoridae
#1
Paola A Magni, Marco Pazzi, Marco Vincenti, Valerio Converso, Ian R Dadour
Entomotoxicology studies employ analytical methods and instrumentation to detect chemical substances in carrion insects feeding from the decomposing tissues. The identification of such chemicals may determine the cause of death and may be used for the estimation of the minimum time since death. To date, the main focus of entomotoxicological studies has been the detection of drugs, whereas little information concerns the effects of pesticides on blowflies. Pesticides are generally freely available and more affordable than drugs but they can also be a home hazard and an accessible candidate poison at a crime scene...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28993024/exposure-to-cocaine-and-its-main-metabolites-altered-the-protein-profile-of-zebrafish-embryos
#2
Marco Parolini, Luca Bini, Stefano Magni, Alessandro Rizzo, Anna Ghilardi, Claudia Landi, Alessandro Armini, Luca Del Giacco, Andrea Binelli
Illicit drugs have been identified as emerging aquatic pollutants because of their widespread presence in freshwaters and potential toxicity towards aquatic organisms. Among illicit drug residues, cocaine (COC) and its main metabolites, namely benzoylecgonine (BE) and ecgonine methyl ester (EME), are commonly detected in freshwaters worldwide at concentration that can induce diverse adverse effects to non-target organisms. However, the information of toxicity and mechanisms of action (MoA) of these drugs, mainly of COC metabolites, to aquatic species is still fragmentary and inadequate...
October 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28992073/urinary-peptide-biomarker-panel-associated-with-an-improvement-in-estimated-glomerular-filtration-rate-in-chronic-kidney-disease-patients
#3
Katerina Markoska, Martin Pejchinovski, Claudia Pontillo, Petra Zürbig, Lotte Jacobs, Andrew Smith, Jelka Masin-Spasovska, Olivera Stojceva-Taneva, Momir Polenakovic, Fulvio Magni, Harald Mischak, Goce Spasovski
Background: An improvement in the glomerular filtration rate (GFR) of chronic kidney disease patients has been an underestimated clinical outcome. Although this may be considered as an unexpected disease course, it may provide some insights into possible mechanisms underlying disease remission and/or regression. Therefore, our aim was to identify urinary peptide biomarkers associated with an improvement in estimated GFR (eGFR) over time and to improve patient stratification. Methods: Capillary electrophoresis coupled with mass spectrometry (CE-MS) was employed to evaluate the urine peptidome of patients with different types of renal diseases...
September 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28972401/mathematical-modeling-of-efficacy-and-safety-for-anticancer-drugs-clinical-development
#4
Silvia Maria Lavezzi, Elisa Borella, Letizia Carrara, Giuseppe De Nicolao, Paolo Magni, Italo Poggesi
Drug attrition in oncology clinical development is higher than other therapeutic areas. In this context, pharmacometric modeling represents a useful tool to explore drug efficacy in earlier phases of clinical development, anticipating overall survival using quantitative model-based metrics. Furthermore, modeling approaches can be used to characterize earlier the safety and tolerability profile of drug candidates, and, thus, the risk-benefit ratio and the therapeutic index, supporting the design of optimal treatment regimens and accelerating the whole process of clinical drug development...
October 3, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28967507/effects-of-zostera-marina-on-the-patterns-of-spatial-distribution-of-sediments-and-macrozoobenthos-in-the-boreal-lagoon-of-furen-hokkaido-japan
#5
P Magni, S Como, A Kamijo, S Montani
Understanding patterns of spatial variations in benthic seagrass assemblages is a central issue in seagrass ecology. However, how patterns of spatial variations in macrozoobenthos and associated sediments differ between vegetated and unvegetated areas remain largely unexplored. In the present study, two different habitats represented by dense Zostera marina beds (Zostera) and unvegetated sediments (Bare) were compared at three locations, 100's meters apart, located at progressive distance from the Furen river in the boreal lagoon of Furen (Hokkaido, Japan)...
September 20, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28955492/prongf-p75ntr-axis-plays-a-proinflammatory-role-in-inflamed-joints-a-novel-pathogenic-mechanism-in-chronic-arthritis
#6
Gaetana Minnone, Marzia Soligo, Ivan Caiello, Giusi Prencipe, Luigi Manni, Denise Pires Marafon, Silvia Magni-Manzoni, Antonio Manzo, Fabrizio De Benedetti, Luisa Bracci-Laudiero
OBJECTIVE: To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammation. METHODS: Real-time PCR, western blot and ELISA were performed to evaluate NGF, proNGF, their receptor and cytokine expression in synovial tissue and cells of patients with juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA), and controls. RESULTS: proNGF and not mNGF is the prevalent form measured in synovial fluids of patients with JIA and RA with synovial fibroblasts as a major source of proNGF in the inflamed synoviae...
2017: RMD Open
https://www.readbyqxmd.com/read/28930828/18f-fdg-pet-ct-in-preoperative-staging-of-vulvar-cancer-patients-is-it-really-effective
#7
Cinzia Crivellaro, Priscilla Guglielmo, Elena De Ponti, Federica Elisei, Luca Guerra, Sonia Magni, Maria La Manna, Giampaolo Di Martino, Claudio Landoni, Alessandro Buda
The aim of this study was to assess the role of 18F-FDG PET/CT in preoperative staging of vulvar cancer patients.29 pts (69 years, range 51-88) with vulvar cancer (clinical apparent stage I-II), underwent preoperative FDG-PET/CT scan followed by radical vulvectomy and bilateral (or monolateral in case of tumor >2 cm from midline) inguinal lymphadenectomy ± sentinel node biopsy. PET/CT images were analyzed in consensus and correlated to histological findings according to a pt-based and a groin-based analyses...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28922194/benign-neonatal-sleep-myoclonus-evokes-somatosensory-responses
#8
Emma Losito, Monika Eisermann, Patricia Vignolo, Shushanik Hovhannisyan, Jean François Magny, Anna Kaminska
PURPOSE: Benign neonatal sleep myoclonus is a common nonepileptic condition occurring in neurologically normal full-term newborns. During jerks, EEG has always been described as normal. The aim of this study was to describe EEG changes associated with the myoclonic jerks. METHODS: Polygraphic video-EEG recordings of four full-term neonates presenting benign neonatal sleep myoclonus were studied. Myoclonic jerks were analyzed regarding their topography, frequency, propagation pattern, and reflex component...
September 14, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28890380/risk-of-exclusion-from-stroke-rehabilitation-in-the-oldest-old
#9
Paola Forti, Fabiola Maioli, Elisabetta Magni, Letizia Regazzoni, Roberto Piperno, Marco Zoli, Maura Coveri, Gaetano Procaccianti
OBJECTIVE: To investigate whether oldest-old age (≥85 yr) is an independent predictor of exclusion from stroke rehabilitation. DESIGN: Retrospective cohort study. SETTING: Stroke Unit (SU) of an Italian tertiary hospital. PARTICIPANTS: 1055 elderly patients (age 65-74 yr, n=230; age, 75-84 yr, n=432; age ≥ 85 yr, n=393), who, between 2009 and 2012, were admitted to SU with acute stroke and evaluated by a multiprofessional team for access to rehabilitation...
September 7, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28888468/effect-of-visual-biofeedback-cycling-training-on-gait-in-patients-with-multiple-sclerosis
#10
A Hochsprung, A Granja Domínguez, E Magni, S Escudero Uribe, A Moreno García
INTRODUCTION: Gait alterations are present in a high percentage of patients with multiple sclerosis (MS). They appear from early stages of the disease and can limit patients' capacity to perform basic activities of daily living, affecting their quality of life. Visual biofeedback cycling training appears to be a useful tool in treating these impairments. This study aims to evaluate the short-term effect of visual biofeedback cycling training on gait in patients with MS. MATERIAL AND METHODS: A total of 61 patients with mild to moderate MS were randomly assigned to a control group and an intervention group...
September 6, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28877086/short-article-retreatment-of-chronic-hepatitis-c-virus-infection-after-unsuccessful-therapy-with-all-oral-direct-acting-antiviral-regimens-a-real-life-experience
#11
Laura Milazzo, Carlo Magni, Fosca Niero, Monica Schiavini, Alessia Lai, Valeria Cento, Francesca Binda, Spinello Antinori, Salvatore Sollima
OBJECTIVE: Few real-life data are available on the retreatment of patients who failed direct-acting antiviral (DAA)-regimens. We reported the outcome of retreatment with approved DAA regimens in a real-life cohort of patients who previously failed an all-oral DAAs combination and we analyzed the association with resistance substitutions (RASs) performed at the time of virological failure. AIM AND METHODS: Next-generation sequencing of the NS3, NS5A, and NS5B regions was performed by Illumina deep sequencing...
November 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28852954/pressure-ulcers-are-associated-with-6-month-mortality-in-elderly-patients-with-hip-fracture-managed-in-orthogeriatric-care-pathway
#12
Emmanuelle Magny, Helene Vallet, Judith Cohen-Bittan, Mathieu Raux, Antony Meziere, Marc Verny, Bruno Riou, Frédéric Khiami, Jacques Boddaert
Despite orthogeriatric management, 12% of the elderly experienced PUs after hip fracture surgery. PUs were significantly associated with a low albumin level, history of atrial fibrillation coronary artery disease, and diabetes. The risk ratio of death at 6 months associated with pressure ulcer was 2.38 (95% CI 1.31-4.32%, p = 0.044). INTRODUCTION: Pressure ulcers in hip fracture patients are frequent and associated with a poor outcome. An orthogeriatric management, recommended by international guidelines in hip fracture patients and including pressure ulcer prevention and treatment, could influence causes and consequences of pressure ulcer...
August 29, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28832504/bi-component-nanostructured-arrays-of-co-dots-embedded-in-ni80fe20-antidot-matrix-synthesis-by-self-assembling-of-polystyrene-nanospheres-and-magnetic-properties
#13
Marco Coïsson, Federica Celegato, Gabriele Barrera, Gianluca Conta, Alessandro Magni, Paola Tiberto
A bi-component nanostructured system composed by a Co dot array embedded in a Ni80Fe20 antidot matrix has been prepared by means of the self-assembling polystyrene nanospheres lithography technique. Reference samples constituted by the sole Co dots or Ni80Fe20 antidots have also been prepared, in order to compare their properties with those of the bi-component material. The coupling between the two ferromagnetic elements has been studied by means of magnetic and magneto-transport measurements. The Ni80Fe20 matrix turned out to affect the vortex nucleation field of the Co dots, which in turn modifies the magneto-resistance behaviour of the system and its spinwave properties...
August 23, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28830099/a-systems-wide-understanding-of-photosynthetic-acclimation-in-algae-and-higher-plants
#14
Fiona Wanjiku Moejes, Anna Matuszynska, Kailash Adhikari, Roberto Bassi, Federica Cariti, Guillaume Cogne, Ioannis Dikaios, Angela Falciatore, Giovanni Finazzi, Serena Flori, Michel Goldschmidt-Clermont, Stefano Magni, Julie Maguire, Adeline Le Monnier, Kathrin Müller, Mark Poolman, Dipali Singh, Stephanie Spelberg, Giulio Rocco Stella, Antonella Succurro, Lucilla Taddei, Brieuc Urbain, Valeria Villanova, Claudia Zabke, Oliver Ebenhöh
The ability of phototrophs to colonise different environments relies on robust protection against oxidative stress, a critical requirement for the successful evolutionary transition from water to land. Photosynthetic organisms have developed numerous strategies to adapt their photosynthetic apparatus to changing light conditions in order to optimise their photosynthetic yield, which is crucial for life on Earth to exist. Photosynthetic acclimation is an excellent example of the complexity of biological systems, where highly diverse processes, ranging from electron excitation over protein protonation to enzymatic processes coupling ion gradients with biosynthetic activity, interact on drastically different timescales from picoseconds to hours...
May 17, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28828861/towards-the-standardization-of-mitochondrial-proteomics-the-italian-mt-hpp-initiative
#15
Tiziana Alberio, Luisa Pieroni, Maurizio Ronci, Cristina Banfi, Italia Bongarzone, Patrizia Bottoni, Maura Brioschi, Marianna Caterino, Clizia Chinello, Antonella Cormio, Flora Cozzolino, Vincenzo Cunsolo, Simona Fontana, Barbara Garavaglia, Laura Giusti, Viviana Greco, Antonio Lucacchini, Elisa Maffioli, Fulvio Magni, Francesca Monteleone, Maria Monti, Valentina Monti, Clara Musicco, Giuseppe Petrosillo, Vito Porcelli, Rosaria Saletti, Roberto Scatena, Alessio Soggiu, Gabriella Tedeschi, Mara Zilocchi, Paola Roncada, Andrea Urbani, Mauro Fasano
The mitochondrial Human Proteome Project aims at understanding the function of the mitochondrial proteome and its crosstalk with the proteome of other organelles. Being able to choose a suitable and validated enrichment protocol of functional mitochondria, based on the specific needs of the downstream proteomics analysis, would greatly help the researchers in the field. Mitochondrial fractions from ten model cell lines were prepared using three enrichment protocols and analyzed on seven different LC-MS/MS platforms...
August 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28796992/abnormal-interhemispheric-synchrony-in-neonatal-hypoxic-ischemic-encephalopathy-a-retrospective-pilot-study
#16
Elise Leroy-Terquem, Anne Isabelle Vermersch, Pauline Dean, Ziad Assaf, Nathalie Boddaert, Alexandre Lapillonne, Jean-François Magny
BACKGROUND: Abnormal interhemispheric synchrony has been described in many clinical compromises in brain function, but its prognostic value in neonatal hypoxic-ischemic encephalopathy (HIE) is unknown. OBJECTIVES: The study aimed at describing the frequency of abnormal interhemispheric synchrony in infants with HIE and to explore its prognostic value. The main outcome was survival without major disabilities. METHODS: We performed a single-center retrospective cohort study and enrolled 40 neonates with HIE who underwent hypothermia...
August 11, 2017: Neonatology
https://www.readbyqxmd.com/read/28777893/age-related-vascularization-and-ossification-of-joints-in-children-an-international-pilot-study-to-test-multi-observer-ultrasound-reliability
#17
Daniel Windschall, Paz Collado, Jelena Vojinovic, Silvia Magni-Manzoni, Peter Balint, George A W Bruyn, Cristina Hernandez-Diaz, Juan Carlos Nieto, Viviana Ravagnani, Nikolay Tzaribachev, Annamaria Iagnocco, Maria Antonietta D'Agostino, Esperanza Naredo
OBJECTIVE: To determine the intra- and inter-observer reliability of ultrasound (US)-detected age-related joint vascularization and ossification grading in healthy children. METHODS: Following standardized image acquisition and machine setting protocols, 10 international US experts examined four joints (wrist, second metacarpophalangeal joint, knee, and ankle) in 12 healthy children (divided into four age groups: 2-4, 5-8, 9-12, and 13-16 years). Grey-scale was used to detect the ossification grade, and power Doppler (PD) US was used to detect physiological vascularization...
August 4, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28754766/divergent-evolution-and-niche-differentiation-within-the-common-peatmoss-sphagnum-magellanicum
#18
Narjes Yousefi, Kristian Hassel, Kjell Ivar Flatberg, Petri Kemppainen, Emiliano Trucchi, A Jonathan Shaw, Magni Olsen Kyrkjeeide, Péter Szövényi, Hans K Stenøien
PREMISE OF THE STUDY: Populations with phenotypic polymorphism in discrete characters may be good models for investigating genome evolution and speciation. Sphagnum magellanicum Brid. is found throughout the northern hemisphere, and despite considerable variation in morphological characters, it is considered one of the least taxonomically controversial peatmoss species. We have observed two main morphs of the species associated with different microhabitats. Here we investigated the genomic and environmental basis of this intraspecific morphological variation...
July 28, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28748995/-effects-of-a-mindfulness-intervention-in-chilean-high-schoolers
#19
RANDOMIZED CONTROLLED TRIAL
Álvaro I Langer, Carlos Schmidt, José Manuel Aguilar-Parra, Cristian Cid, Antonella Magni
BACKGROUND: Mindfulness has been conceptualized as paying attention to present moment experience in a non-judgmental manner, and the practice of developing that skill. AIM: To determine the impact of a mindfulness-based intervention on negative emotional states of anxiety, stress, and depression in Chilean high schoolers. MATERIAL AND METHODS: Eighty-eight teenagers aged 13 ± 0.6 years (46 females) were randomly assigned to a mindfulness group or a control (41 and 47, respectively)...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28720146/analysis-of-long-term-cd4-cd25highcd127-t-reg-cells-kinetics-in-peripheral-blood-of-lung-transplant-recipients
#20
Davide Piloni, Monica Morosini, Sara Magni, Alice Balderacchi, Luigia Scudeller, Emanuela Cova, Tiberio Oggionni, Giulia Stella, Carmine Tinelli, Filippo Antonacci, Andrea Maria D'Armini, Federica Meloni
BACKGROUND: The role of CD4(+)CD25(high)CD127(-) T-reg cells in solid-organ Transplant (Tx) acceptance has been extensively studied. In previous studies on kidney and liver recipients, peripheral T-reg cell counts were associated to graft survival, while in lung Tx, there is limited evidence for similar findings. This study aims to analyze long term peripheral kinetics of T-reg-cells in a cohort of lung recipients and tests its association to several clinical variables. METHODS: From jan 2009 to dec 2014, 137 lung Tx recipients were submitted to an immunological follow up (median: 105...
July 18, 2017: BMC Pulmonary Medicine
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