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https://www.readbyqxmd.com/read/28425413/ursodeoxycholic-acid-therapy-in-patients-with-primary-biliary-cholangitis-with-limited-liver-transplantation-availability
#1
Yazmín Karel Melchor-Mendoza, Braulio Martínez-Benítez, Aline Mina-Hawat, Gustavo Rodríguez-Leal, Ximena Duque, Segundo Moran-Villota
INTRODUCTION: There is little information on survival rates of patients with primary biliary cholangtis (PBC) in developing countries. This is particularly true in Latin America, where the number of liver transplants performed remains extremely low for patients with advanced liver disease who fulfill criteria for liver transplantation. The goal of this study was to compare survival rate of patients with PBC in developing countries who were treated with ursodeoxycholic acid (UDCA) versus survival of patients who received other treatments (OT) without UDCA, prescribed before the UDCA era...
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28425308/the-effect-of-molecular-weights-of-microencapsulating-polymers-on-viability-of-mouse-cloned-pancreatic-%C3%AE-cells-biomaterials-osmotic-forces-and-potential-applications-in-diabetes-treatment
#2
Armin Mooranian, Ryu Tackechi, Emma Jamieson, Grant Morahan, Hani Al-Salami
INTRODUCTION: Ideal cell-containing microcapsules should be capable of maintaining cell viability and exhibit significant structural stability to support cellular functionality. To date, such microcapsules remain unavailable, thus, this study used our well-established microencapsulating methods to examine a total of 32 different microencapsulating formulations and correlate polymers' molecular weights (Mwt) and UDCA addition, with cell viability and microcapsules' stability, postmicroencapsulation...
April 20, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28417463/pharmacological-interventions-for-primary-sclerosing-cholangitis-an-attempted-network-meta-analysis
#3
REVIEW
Francesca Saffioti, Kurinchi Selvan Gurusamy, Neil Hawkins, Clare D Toon, Emmanuel Tsochatzis, Brian R Davidson, Douglas Thorburn
BACKGROUND: Primary sclerosing cholangitis is a chronic cholestatic liver disease that is associated with both hepatobiliary and colorectal malignancies, which can result in liver cirrhosis and its complications. The optimal pharmacological treatment for patients with primary sclerosing cholangitis remains controversial. OBJECTIVES: To assess the comparative benefits and harms of different pharmacological interventions in people with primary sclerosing cholangitis by performing a network meta-analysis, and to generate rankings of available pharmacological interventions according to their safety and efficacy...
March 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28382327/proton-pump-inhibitor-is-a-risk-factor-for-recurrence-of-common-bile-duct-stones-after-endoscopic-sphincterotomy-propensity-score-matching-analysis
#4
Nobuhiko Fukuba, Shunji Ishihara, Hiroki Sonoyama, Noritsugu Yamashita, Masahito Aimi, Yoshiyuki Mishima, Tsuyoshi Mishiro, Hiroshi Tobita, Koutarou Shibagaki, Naoki Oshima, Ichiro Moriyama, Kousaku Kawashima, Tatsuya Miyake, Norihisa Ishimura, Shuichi Sato, Yoshikazu Kinoshita
Background and study aims Recurrence of common bile duct stones (CBDS) in patients treated with endoscopic sphincterotomy (ES) can lead to deterioration in their quality of life. Although the pathology and related factors are unclear, we speculated that proton pump inhibiter (PPI) administration increases the risk of CBDS recurrence by altering the bacterial mixture in the bile duct. Patients and methods The primary endpoint of this retrospective study was recurrence-free period. Several independent variables considered to have a relationship with CBDS recurrence including PPI use were analyzed using a COX proportional hazard model, with potential risk factors then evaluated by propensity score matching analysis...
April 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28382282/ursodeoxycholic-acid-induces-death-receptor-mediated-apoptosis-in-prostate-cancer-cells
#5
Won Sup Lee, Ji Hyun Jung, Radha Panchanathan, Jeong Won Yun, Dong Hoon Kim, Hye Jung Kim, Gon Sup Kim, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi, Jin-Myung Jung
BACKGROUND: Bile acids have anti-cancer properties in a certain types of cancers. We determined anticancer activity and its underlying molecular mechanism of ursodeoxycholic acid (UDCA) in human DU145 prostate cancer cells. METHODS: Cell viability was measured with an MTT assay. UDCA-induced apoptosis was determined with flow cytometric analysis. The expression levels of apoptosis-related signaling proteins were examined with Western blotting. RESULTS: UDCA treatment significantly inhibited cell growth of DU145 in a dose-dependent manner...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28371104/old-and-new-treatments-for-primary-biliary-cholangitis
#6
David Chascsa, Elizabeth J Carey, Keith D Lindor
Primary biliary cholangitis (formerly primary biliary cirrhosis) is a rare progressive cholestatic liver disease, whose hallmark features include a persistently elevated alkaline phosphatase level, presence of anti-mitochondrial antibodies and characteristic histology. Since 1998, ursodeoxycholic acid (UDCA), a bile acid, has been the only available therapeutic agent. Primary biliary cholangitis is associated with the development of end-stage liver disease, increased morbidity and mortality. UDCA has been shown to improve serum biochemistries, histology and delay the need for liver transplantation...
April 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28371099/finding-the-cure-for-primary-biliary-cholangitis-still-waiting
#7
Atsushi Tanaka, M Eric Gershwin
The introduction of ursodeoxycholic acid (UDCA)may well have contributed to some of the improvements in morbidity and mortality of primary biliary cholangitis (PBC). Yet nearly 40% of PBC patients are unresponsive to UDCA. Further the data on UDCA is confounded by the changes in the goepidemiology and particularly the earlier diagnosis of PBC. In this regard we welcome the addition of obeticholic acid (OCA) as an alternative therapeutic option forthe treatment of PBC in those patients refractory to UDCA. However, OCA is intellectually disappointing...
April 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28360029/ursodeoxycholic-acid-and-lithocholic-acid-exert-anti-inflammatory-actions-in-the-colon
#8
Joseph B J Ward, Natalia K Lajczak, Orlaith B Kelly, Aoife M O'Dwyer, Ashwini K Giddam, Joan N Ní Gabhainn, Placido Franco, Murtaza M Tambuwala, Caroline A Jefferies, Simon Keely, Aldo Roda, Stephen Joseph Keely
Inflammatory bowel diseases (IBD) are a group of common and debilitating chronic intestinal disorders for which currently-available therapies are often unsatisfactory. The naturally-occurring secondary bile acid, ursodeoxycholic acid (UDCA), has well-established anti-inflammatory and cytoprotective actions and may therefore be effective in treating IBD. Here, we aimed to investigate regulation of colonic inflammatory responses by UDCA and to determine the potential impact of bacterial metabolism on its therapeutic actions...
March 30, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28350426/pharmacological-interventions-for-primary-biliary-cholangitis-an-attempted-network-meta-analysis
#9
REVIEW
Francesca Saffioti, Kurinchi Selvan Gurusamy, Leonardo Henry Eusebi, Emmanuel Tsochatzis, Brian R Davidson, Douglas Thorburn
BACKGROUND: Primary biliary cholangitis (previously primary biliary cirrhosis) is a chronic liver disease caused by the destruction of small intra-hepatic bile ducts resulting in stasis of bile (cholestasis), liver fibrosis, and liver cirrhosis. The optimal pharmacological treatment of primary biliary cholangitis remains uncertain. OBJECTIVES: To assess the comparative benefits and harms of different pharmacological interventions in the treatment of primary biliary cholangitis through a network meta-analysis and to generate rankings of the available pharmacological interventions according to their safety and efficacy...
March 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28315136/ursodeoxycholic-acid-suppresses-lipogenesis-in-mouse-liver-possible-role-of-the-decrease-in-%C3%AE-muricholic-acid-a-farnesoid-x-receptor-antagonist
#10
Kyosuke Fujita, Yusuke Iguchi, Mizuho Une, Shiro Watanabe
The farnesoid X receptor (FXR) is a major nuclear receptor of bile acids; its activation suppresses sterol regulatory element-binding protein 1c (SREBP1c)-mediated lipogenesis and decreases the lipid contents in the liver. There are many reports showing that the administration of ursodeoxycholic acid (UDCA) suppresses lipogenesis and reduces the lipid contents in the liver of experimental animals. Since UDCA is not recognized as an FXR agonist, these effects of UDCA cannot be readily explained by its direct activation of FXR...
March 17, 2017: Lipids
https://www.readbyqxmd.com/read/28289997/innovative-microcapsules-for-pancreatic-%C3%AE-cells-harvested-from-mature-double-transgenic-mice-cell-imaging-viability-induced-glucose-stimulated-insulin-measurements-and-proinflammatory-cytokines-analysis
#11
Armin Mooranian, Ryu Tackechi, Emma Jamieson, Grant Morahan, Hani Al-Salami
PURPOSE: Recently we demonstrated that microencapsulation of a murine pancreatic β-cell line using an alginate-ursodeoxycholic acid (UDCA) matrix produced microcapsules with good stability and cell viability. In this study, we investigated if translation of this formulation to microencapsulation of primary β-cells harvested from mature double-transgenic healthy mice would also generate stable microcapsules with good cell viability. METHODS: Islets of Langerhans were isolated from Ngn3-GFP/RIP-DsRED mice by intraductal collagenase P digestion and density gradient centrifugation, dissociated into single cells and the β-cell population purified by Fluorescence Activated Cell Sorting...
March 13, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28256288/beneficial-effects-of-ursodeoxycholic-acid-via-inhibition-of-airway-remodelling-apoptosis-of-airway-epithelial-cells-and-th2-immune-response-in-murine-model-of-chronic-asthma
#12
S Işık, M Karaman, S Çilaker Micili, Ş Çağlayan-Sözmen, H Alper Bağrıyanık, Z Arıkan-Ayyıldız, N Uzuner, Ö Karaman
BACKGROUND AND AIMS: In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling, epithelial apoptosis, and T Helper (Th)-2 derived cytokine levels in a murine model of chronic asthma. METHODS: Twenty-seven BALB/c mice were divided into five groups; PBS-Control, OVA-Placebo, OVA-50mg/kg UDCA, OVA-150mg/kg UDCA, OVA-Dexamethasone...
February 27, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28255561/genetic-contribution-to-the-pathogenesis-of-primary-biliary-cholangitis
#13
REVIEW
Satoru Joshita, Takeji Umemura, Eiji Tanaka, Masao Ota
Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies. Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a favorable outcome in the vast majority of cases. Although the etiology of PBC has not yet been elucidated, human leukocyte antigen (HLA) class II alleles have been consistently associated with disease onset for decades...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28249268/bile-acids-in-polycystic-liver-diseases-triggers-of-disease-progression-and-potential-solution-for-treatment
#14
Maria J Perugorria, Ibone Labiano, Aitor Esparza-Baquer, Marco Marzioni, Jose J G Marin, Luis Bujanda, Jesús M Banales
Polycystic liver diseases (PLDs) are a group of genetic hereditary cholangiopathies characterized by the development and progressive growth of cysts in the liver, which are the main cause of morbidity. Current therapies are based on surgical procedures and pharmacological strategies, which show short-term and modest beneficial effects. Therefore, the determination of the molecular mechanisms of pathogenesis appears to be crucial in order to find new potential targets for pharmacological therapy. Ductal plate malformation during embryogenesis and abnormal cystic cholangiocyte growth and secretion are some of the key mechanisms involved in the pathogenesis of PLDs...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28249264/bile-acids-and-deregulated-cholangiocyte-autophagy-in-primary-biliary-cholangitis
#15
Motoko Sasaki, Yasuni Nakanuma
BACKGROUND: Primary biliary cholangitis (PBC) is characterized by a high prevalence of serum anti-mitochondrial antibodies against the E2 subunit of the pyruvate dehydrogenase complex and bile duct lesions called chronic non-suppurative destructive cholangitis (CNSDC) in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. Macroautophagy (a major type of autophagy) is a process of cellular self-digestion that plays a critical role in energy homeostasis and in the cytoprotection to various stresses...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28249257/therapeutic-mechanisms-of-bile-acids-and-nor-ursodeoxycholic-acid-in-non-alcoholic-fatty-liver-disease
#16
Daniel Steinacher, Thierry Claudel, Michael Trauner
Non-alcoholic fatty liver disease is one of the most rapidly rising clinical problems in the 21st century. So far no effective drug treatment has been established to cure this disease. Bile acids (BAs) have a variety of signaling properties, which can be used therapeutically for modulating hepatic metabolism and inflammation. A side-chain shorted derivative of ursodeoxycholic acid (UDCA) is 24 nor-ursodeoxycholic acid (NorUDCA) and it represents a new class of drugs for treatment of liver diseases. NorUDCA has unique biochemical and therapeutic properties, since it is relatively resistant to conjugation with glycine or taurine compared to UDCA...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28239165/antihypertensive-agents-do-not-prevent-blood-brain-barrier-dysfunction-and-cognitive-deficits-in-dietary-induced-obese-mice
#17
J C L Mamo, V Lam, C Giles, S H Coulson, N Fimognari, A Mooranian, H Al-Salami, R Takechi
BACKGROUND: While vascular risk factors including Western-styled diet and obesity are reported to induce cognitive decline and increase dementia risk, recent reports consistently suggest that compromised integrity of cerebrovascular blood-brain barrier (BBB) may have an important role in neurodegeneration and cognitive deficits. A number of studies report that elevated blood pressure increases the permeability of BBB. METHODS: In this study, we investigated the effects of antihypertensive agents, candesartan or ursodeoxycholic acid (UDCA), on BBB dysfunction and cognitive decline in wild-type mice maintained on high fat and fructose (HFF) diet for 24 weeks...
March 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28238692/management-of-pruritus-in-primary-biliary-cholangitis-a-narrative-review
#18
REVIEW
Hirsh D Trivedi, Blanca Lizaola, Elliot B Tapper, Alan Bonder
Primary biliary cholangitis is an autoimmune condition characterized by destruction of intrahepatic bile ducts. It causes debilitating symptoms, which dramatically affect the patient's quality of life. Pruritus affects 60% to 70% of individuals with primary biliary cholangitis and leads to sleep disturbances, fatigue, depression and suicidal ideation. A complete search was done with studies from PubMed, EMBASE, Web of Science, Cochrane database, Countway library and CINAHL with specific search terms. This narrative review was prepared after a comprehensive literature review...
February 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28236406/lc-ms-ms-analysis-and-pharmacokinetic-study-on-five-bioactive-constituents-of-tanreqing-injection-in-rats
#19
Feng Zhang, Liang Sun, Shou-Hong Gao, Wan-Sheng Chen, Yi-Feng Chai
Tanreqing injection (TRQ), a well-known traditional Chinese medicine formula, is commonly used to treat respiratory diseases. In the present study, a rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determinate the plasma contents of 5 major constituents of TRQ, including chlorogenic acid (CHA), caffeic acid (CFA), baicalin (BA), ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in rats after intravenous administration of TRQ...
October 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28219198/-effects-and-mechanisms-of-ursodeoxycholic-acid-on-isoprenaline-induced-myocardial-fibrosis-in-mice
#20
X Li, K Q Han, Y N Shi, S Z Men, S Li, M H Sun, H Dong, J J Lu, L J Ma, M Zhao, D Li, W Liu
Objective: To investigate the effects and possible mechanisms of ursodeoxycholic acid (UDCA) on myocardial fibrosis in mice. Method: To observe the expression of transforming growth factor(TGF) -β1, CTGF, MMPs and the degree of myocardial fibrosis, 61 male Kunming mice were randomly divided into normal group, low dose UDCA group, high dose of UDCA group, spironolactone group, and the control group.Isoproterenol (ISO) injection was given subcutaneously (30 d) to make the model of myocardial fibrosis.Corresponding anti-fibrosis drugs (UDCA or spironolactone) were given by gavage...
February 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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