Fei Li, Xudong Xing, Qiqi Jin, Xiang-Ming Wang, Pengfei Dai, Ming Han, Huili Shi, Ze Zhang, Xianlong Shao, Yunyi Peng, Yiqin Zhu, Jiayi Xu, Dan Li, Yu Chen, Wei Wu, Qiao Wang, Chen Yu, Luonan Chen, Fan Bai, Dong Gao
Sex differences in mammalian complex traits are prevalent and are intimately associated with androgens1-7 . However, a molecular and cellular profile of sex differences and their modulation by androgens is still lacking. Here we constructed a high-dimensional single-cell transcriptomic atlas comprising over 2.3 million cells from 17 tissues in Mus musculus and explored the effects of sex and androgens on the molecular programs and cellular populations. In particular, we found that sex-biased immune gene expression and immune cell populations, such as group 2 innate lymphoid cells, were modulated by androgens...
April 10, 2024: Nature