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https://www.readbyqxmd.com/read/28727808/automatic-mouse-ultrasound-detector-a-mud-a-new-tool-for-processing-rodent-vocalizations
#1
Sarah M Zala, Doris Reitschmidt, Anton Noll, Peter Balazs, Dustin J Penn
House mice (Mus musculus) emit complex ultrasonic vocalizations (USVs) during social and sexual interactions, which have features similar to bird song (i.e., they are composed of several different types of syllables, uttered in succession over time to form a pattern of sequences). Manually processing complex vocalization data is time-consuming and potentially subjective, and therefore, we developed an algorithm that automatically detects mouse ultrasonic vocalizations (Automatic Mouse Ultrasound Detector or A-MUD)...
2017: PloS One
https://www.readbyqxmd.com/read/28722586/continuous-excretion-of-leptospira-borgpetersenii-ballum-in-mice-assessed-by-viability-quantitative-polymerase-chain-reaction
#2
Marie-Estelle Soupé-Gilbert, Emilie Bierque, Sophie Geroult, Magali Teurlai, Cyrille Goarant
Rodents are the main reservoir animals of leptospirosis. In this study, we characterized and quantified the urinary excretion dynamics of Leptospira by Mus musculus infected with 2 × 10(8) virulent Leptospira borgpetersenii serogroup Ballum. Each micturition was collected separately in metabolic cages, at 12 time points from 7 to 117 days post-infection (dpi). We detected Leptospira in all urine samples collected (up to 8 per time point per mouse) proving that Leptospira excretion is continuous with ca. 90% live L...
July 17, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721358/utah-optrode-array-customization-using-stereotactic-brain-atlases-and-3-d-cad-modeling-for-optogenetic-neocortical-interrogation-in-small-rodents-and-nonhuman-primates
#3
Ronald W Boutte, Sam Merlin, Guy Yona, Brandon Griffiths, Alessandra Angelucci, Itamar Kahn, Shy Shoham, Steve Blair
As the optogenetic field expands, the need for precise targeting of neocortical circuits only grows more crucial. This work demonstrates a technique for using Solidworks(®) computer-aided design (CAD) and readily available stereotactic brain atlases to create a three-dimensional (3-D) model of the dorsal region of area visual cortex 4 (V4D) of the macaque monkey (Macaca fascicularis) visual cortex. The 3-D CAD model of the brain was used to customize an [Formula: see text] Utah optrode array (UOA) after it was determined that a high-density ([Formula: see text]) UOA caused extensive damage to marmoset (Callithrix jacchus) primary visual cortex as assessed by electrophysiological recording of spiking activity through a 1...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/28720579/recruitment-of-histone-modifications-to-assist-mrna-dosage-maintenance-after-degeneration-of-cytosine-dna-methylation-during-animal-evolution
#4
Andrew Yf Chang, Ben-Yang Liao
Following gene duplication, mRNA expression of the duplicated gene is reduced to maintain mRNA dosage. In mammals, this process is achieved with increased cytosine DNA methylation of the promoters of duplicated genes to suppress transcriptional initiation. However, not all animal species possess a full apparatus for cytosine DNA methylation. For such species such as roundworm (Caenorhabditis elegans, "worm" hereafter) or fruit fly (Drosophila melanogaster, "fly" hereafter), it is unclear how reduced expression of duplicated genes has been achieved evolutionarily...
July 18, 2017: Genome Research
https://www.readbyqxmd.com/read/28719007/validating-activity-indices-from-camera-traps-for-commensal-rodents-and-other-wildlife-in-and-around-farm-buildings
#5
Mark Lambert, Fiona Bellamy, Richard Budgey, Rebecca Callaby, Julia Coats, Janet Talling
BACKGROUND: Indices of rodent activity are used as indicators of population change during field evaluation of rodenticides. We investigated the potential for using camera traps to determine activity indices for commensal rodents living in and around farm buildings, and sought to compare these indices against previously calibrated survey methods. RESULTS: We recorded 41, 263 images of 23 species including Norway rats (Rattus norvegicus Berk.) and house mice (Mus musculus L...
July 18, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28708106/evodiamine-exerts-an-anti-hepatocellular-carcinoma-activity-through-a-wwox-dependent-pathway
#6
Che-Yuan Hu, Hung-Tsung Wu, Yu-Chu Su, Ching-Han Lin, Chih-Jen Chang, Chao-Liang Wu
Evodiamine is one of the main components isolated from Evodia rutaecarpa, and it has been reported to exert inhibitory effects on cancers by anti-proliferative and apoptosis-inducing activities. Although the anti-cancer activity of evodiamine has been identified, the precise mechanisms of this action remain obscure. While previous studies indicated that evodiamine exerts anti-tumor effects through inhibiting β-catenin activity, and WW domain-containing oxidoreductase (WWOX) regulates β-catenin accumulation in cytoplasm, the effects of evodiamine on the expression of WWOX are still unknown...
July 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28698824/on-the-tear-proteome-of-the-house-mouse-mus-musculus-musculus-in-relation-to-chemical-signalling
#7
Romana Stopkova, Petr Klempt, Barbora Kuntova, Pavel Stopka
Mammalian tears are produced by lacrimal glands to protect eyes and may function in chemical communication and immunity. Recent studies on the house mouse chemical signalling revealed that major urinary proteins (MUPs) are not individually unique in Mus musculus musculus. This fact stimulated us to look for other sexually dimorphic proteins that may-in combination with MUPs-contribute to a pool of chemical signals in tears. MUPs and other lipocalins including odorant binding proteins (OBPs) have the capacity to selectively transport volatile organic compounds (VOCs) in their eight-stranded beta barrel, thus we have generated the tear proteome of the house mouse to detect a wider pool of proteins that may be involved in chemical signalling...
2017: PeerJ
https://www.readbyqxmd.com/read/28693627/morphofunctional-evaluation-of-the-testis-duration-of-spermatogenesis-and-spermatogenic-efficiency-in-the-japanese-fancy-mouse-mus-musculus-molossinus
#8
Guilherme M J Costa, Marcelo C Leal, Luiz R França
Japanese fancy mouse, mini mouse or pet mouse are common names used to refer to strains of mice that present with different colour varieties and coat types. Although many genetic studies that involve spotting phenotype based on the coat have been performed in these mice, there are no reports of quantitative data in the literature regarding testis structure and spermatogenic efficiency. Hence, in this study we researched testis function and spermatogenesis in the adult Japanese fancy mouse. The following values of 68 ± 6 mg and 0...
July 11, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28689507/a-survey-of-zoonotic-pathogens-carried-by-house-mouse-and-black-rat-populations-in-yucatan-mexico
#9
J A Panti-May, R R C DE Andrade, Y Gurubel-González, E Palomo-Arjona, L Sodá-Tamayo, J Meza-Sulú, M Ramírez-Sierra, E Dumonteil, V M Vidal-Martínez, C Machaín-Williams, D DE Oliveira, M G Reis, M A Torres-Castro, M R Robles, S F Hernández-Betancourt, F Costa
The house mouse (Mus musculus) and the black rat (Rattus rattus) are reservoir hosts for zoonotic pathogens, several of which cause neglected tropical diseases (NTDs). Studies of the prevalence of these NTD-causing zoonotic pathogens, in house mice and black rats from tropical residential areas are scarce. Three hundred and two house mice and 161 black rats were trapped in 2013 from two urban neighbourhoods and a rural village in Yucatan, Mexico, and subsequently tested for Trypanosoma cruzi, Hymenolepis diminuta and Leptospira interrogans...
July 10, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28676531/mtdna-polymorphism-and-metabolic-inhibition-affect-sperm-performance-in-conplastic-mice
#10
Maximiliano Tourmente, Misa Hirose, Saleh Ibrahim, Damian Dowling, Daniel Tompkins, Eduardo R S Roldan, Neil Gemmell
A broad link exists between nucleotide substitutions in the mitochondrial genome (mtDNA) and a range of metabolic pathologies, but the exploration of the effect of specific mtDNA genotypes is on-going. Mitochondrial DNA mutations are of particular relevance for reproductive traits, because they are expected to have profound effects on male specific processes as a result of the strict maternal inheritance of mtDNA. Sperm motility is crucially dependent on ATP in most systems studied. However, the importance of mitochondrial function in the production of the ATP necessary for sperm function remains uncertain...
July 4, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28669950/-screening-of-biomarkers-related-with-leukocyte-responses-early-after-burn-injury-in-mice-by-differential-gene-expression-profiling
#11
Qiong Zou, Yan-Bin Gao, Hui Jin, Zhi-Yang Lu, Peng-Wei Shi, Lei Yang
OBJECTIVE: To screen the genes related with leukocyte responses in mice early after burn injury by bioinformatic analysis of the gene expression profiling data. METHODS: The gene expression profiles were obtained from GEO (GSE7404, Mouse musculus, 25% TBSA, full-thickness) database. T test, fold changes and GO functional enrichment analysis were used to identify the differentially expressed genes (DEGs) related to leukocyte responses to burns; the interacting genes were transferred to STRING to construct the protein-protein interaction (PPI) network...
June 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28666356/modphea-model-organism-phenotype-enrichment-analysis-of-eukaryotic-gene-sets
#12
Meng-Pin Weng, Ben-Yang Liao
Motivation: Genome-scale phenotypic data are available for many model organisms, yet existing tools to functionally interpret gene sets from these phenotypic data are largely based on mutagenesis-derived phenotypes observed in mouse or human. Results: Data from both mutagenesis and knockdown experiments are incorporated into mod PhEA to allow users to perform enrichment analyses based on phenotypes observed in budding yeast ( Saccharomyces cerevisiae ), roundworm ( Caenorhabditis elegans ), fruit fly ( Drosophila melanogaster ), zebrafish ( Danio rerio ), mouse ( Mus musculus ), and humans ( Homo sapiens )...
June 29, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28664829/quantification-of-induced-hypothermia-from-aseptic-scrub-applications-during-rodent-surgery-preparation
#13
Anna M Skorupski, Jingyi Zhang, Danielle Ferguson, Frank Lawrence, F Claire Hankenson
Laboratory mice (Mus musculus) are prone to develop hypothermia during anesthesia for surgery, thus potentially impedinganesthetic recovery, wound healing, and future health. The core body temperatures of isoflurane-anesthetized mice areinfluenced by the choice of supplemental heat sources; however, the contribution of various surgical scrubs on the bodytemperatures of mice under gas anesthesia has not been assessed. We sought to quantify the effect of using alcohol (70%isopropyl alcohol [IPA]) compared with saline to rinse away surgical scrub on the progression of hypothermia in anesthetizedmice (n = 47)...
June 29, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28662754/animal-models-of-ebolavirus-infection
#14
Marisa C St Claire, Dan R Ragland, Laura Bollinger, Peter B Jahrling
Ebola virus is a highly pathogenic member of the family Filoviridae that causes a severe hemorrhagic disease in humans and NHP. The 2013-2016 West African outbreak has increased interest in the development and refinement of animal models of Ebola virus disease. These models are used to test countermeasures and vaccines, gain scientific insights into the mechanisms of disease progression and transmission, and study key correlates of immunology. Ebola virus is classified as a BSL4 pathogen and Category A agent, for which the United States government requires preparedness in case of bioterrorism...
June 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28660292/bartonella-in-rodents-and-ectoparasites-in-the-canary-islands-spain-new-insights-into-host-vector-pathogen-relationships
#15
Estefania Abreu-Yanes, Aaron Martin-Alonso, Natalia Martin-Carrillo, Katherine Garcia Livia, Alessandro Marrero-Gagliardi, Basilio Valladares, Carlos Feliu, Pilar Foronda
Bartonella genus is comprised of several species of zoonotic relevance and rodents are reservoirs for some of these Bartonella species. As there were no data about the range of Bartonella species circulating among rodents in the Canary Islands, our main aim was to overcome this lack of knowledge by targeting both the citrate synthase (gltA) and the RNA polymerase beta subunit (rpoB) genes. A total of 181 small mammals and 154 ectoparasites were obtained in three of the Canary Islands, namely Tenerife, La Palma, and Lanzarote...
June 28, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28656622/a-population-level-atlas-of-mus-musculus-craniofacial-skeleton-and-automated-image-based-shape-analysis
#16
A Murat Maga, Nicholas J Tustison, Brian B Avants
Laboratory mice are staples for evo/devo and genetics studies. Inbred strains provide a uniform genetic background to manipulate and understand gene-environment interactions, while their crosses have been instrumental in studies of genetic architecture, integration and modularity, and mapping of complex biological traits. Recently, there have been multiple large-scale studies of laboratory mice to further our understanding of the developmental basis, evolution, and genetic control of shape variation in the craniofacial skeleton (i...
June 28, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28653484/theoretical-implications-of-quantitative-properties-of-interval-timing-and-probability-estimation-in-mouse-and-rat
#17
Aaron Kheifets, David Freestone, C R Gallistel
In three experiments with mice ( Mus musculus ) and rats (Rattus norvigicus), we used a switch paradigm to measure quantitative properties of the interval-timing mechanism. We found that: 1) Rodents adjusted the precision of their timed switches in response to changes in the interval between the short and long feed latencies (the temporal goalposts). 2) The variability in the timing of the switch response was reduced or unchanged in the face of large trial-to-trial random variability in the short and long feed latencies...
July 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/28652137/subspecies-specific-response-to-acth-challenge-test-in-the-house-mouse-mus-musculus
#18
K Daniszová, O Mikula, M Macholán, I Pospíšilová, B Vošlajerová Bímová, Z Hiadlovská
Long term changes in hormonal levels of small and rare animal species can be effectively monitored by non-invasive methods such as immunoenzymatic analysis. These methods generally analyze metabolites instead of the hormone itself and thus do not invade the organism. However, they can be influenced by many factors, so before they are used, they need to be validated. For this purpose we used the "ACTH challenge" test based on stimulating the animal's adrenocortical activity and measuring the consequent increase of the level of its glucocorticoid ("stress") hormones...
June 23, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28651089/validation-of-commercial-real-time-pcr-arrays-for-environmental-risk-assessment-application-to-the-study-of-p-p%C3%A2-dde-toxicity-in-mus-spretus-mice-liver
#19
Noelia Morales-Prieto, Carmen Pueyo, Nieves Abril
Data on gene transcription profiles provide a comprehensive assessment of the toxic and defensive mechanisms that are triggered by pollutants. PCR-arrays have emerged as a reliable tool for analyzing the expression of a panel of relevant, pathway- or disease-focused genes under uniform cycling conditions. By using SYBR Green-optimized primer assays, it is possible to simultaneously amplify a sample with high specificity and amplification efficiencies. However, commercial PCR-arrays target a limited group of organisms, excluding most of those with environmental relevance, as is the case with Mus spretus mice...
June 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28650973/interferon-signaling-in-peromyscus-leucopus-confers-a-potent-and-specific-restriction-to-vector-borne-flaviviruses
#20
Adaeze O Izuogu, Kristin L McNally, Stephen E Harris, Brian H Youseff, John B Presloid, Christopher Burlak, Jason Munshi-South, Sonja M Best, R Travis Taylor
Tick-borne flaviviruses (TBFVs), including Powassan virus and tick-borne encephalitis virus cause encephalitis or hemorrhagic fevers in humans with case-fatality rates ranging from 1-30%. Despite severe disease in humans, TBFV infection of natural rodent hosts has little noticeable effect. Currently, the basis for resistance to disease is not known. We hypothesize that the coevolution of flaviviruses with their respective hosts has shaped the evolution of potent antiviral factors that suppress virus replication and protect the host from lethal infection...
2017: PloS One
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