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https://www.readbyqxmd.com/read/29242385/differential-regulation-of-zfp30-expression-in-murine-airway-epithelia-through-altered-binding-of-zfp148-to-rs51434084
#1
Lucas T Laudermilk, Joseph M Thomas, Samir N Kelada
Neutrophil chemotaxis to the airways is a key aspect of host response to microbes and a feature of multiple pulmonary diseases including asthma. Tight regulation of this recruitment is critical to prevent unwanted host tissue damage and inflammation. Using a mouse (Mus musculus) model of asthma applied to the Collaborative Cross (CC), we previously identified a lung gene expression quantitative trait locus (eQTL) for Zinc finger protein 30 (Zfp30) that was also a QTL for neutrophil recruitment and the hallmark neutrophil chemokine CXCL1...
December 14, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29236926/genome-of-leptospira-borgpetersenii-strain-4e-a-highly-virulent-isolate-obtained-from-mus-musculus-in-southern-brazil
#2
Marcus Redü Eslabão, Frederico Schmitt Kremer, Rommel Thiago Juca Ramos, Artur Luiz da Costa da Silva, Vasco Ariston de Carvalho Azevedo, Luciano da Silva Pinto, Éverton Fagonde da Silva, Odir Antônio Dellagostin
A previous study by our group reported the isolation and characterisation of Leptospira borgpetersenii serogroup Ballum strain 4E. This strain is of particular interest because it is highly virulent in the hamster model. In this study, we performed whole-genome shotgun genome sequencing of the strain using the SOLiD sequencing platform. By assembling and analysing the new genome, we were able to identify novel features that have been previously overlooked in genome annotations of other strains belonging to the same species...
February 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29236704/sex-dependent-modulation-of-ultrasonic-vocalizations-in-house-mice-mus-musculus-musculus
#3
Sarah M Zala, Doris Reitschmidt, Anton Noll, Peter Balazs, Dustin J Penn
House mice (Mus musculus) emit ultrasonic vocalizations (USVs), which are surprisingly complex and have features of bird song, but their functions are not well understood. Previous studies have reported mixed evidence on whether there are sex differences in USV emission, though vocalization rate or other features may depend upon whether potential receivers are of the same or opposite sex. We recorded the USVs of wild-derived adult house mice (F1 of wild-caught Mus musculus musculus), and we compared the vocalizations of males and females in response to a stimulus mouse of the same- or opposite-sex...
2017: PloS One
https://www.readbyqxmd.com/read/29232754/-measurement-of-the-strength-of-human-musculus-orbicularis-oculi-using-video-analysis
#4
Anita Koschmieder, Phillip Pisowocki, Carmen Zietz, Rainer Bader, Oliver Stachs, Anselm Jünemann
Introduction Current methods to measure the of strength of the musculus orbicularis oculi are limited by high proneness to examiner error or by their complex and impracticable set-ups. Our aim was to develop a simple and practicable method to measure eye lid power via video analysis. Methods 50 healthy subjects were included. A deformable single use lid speculum was used. Forced maximum lid closure was recorded via a video slit lamp. Analysis of the video data was performed with open source tracking software...
December 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29230292/multiple-steroid-and-thyroid-hormones-detected-in-baleen-from-eight-whale-species
#5
Kathleen E Hunt, Nadine S Lysiak, Jooke Robbins, Michael J Moore, Rosemary E Seton, Leigh Torres, C Loren Buck
Recent studies have demonstrated that some hormones are present in baleen powder from bowhead (Balaena mysticetus) and North Atlantic right (Eubalaena glacialis) whales. To test the potential generalizability of this technique for studies of stress and reproduction in large whales, we sought to determine whether all major classes of steroid and thyroid hormones are detectable in baleen, and whether these hormones are detectable in other mysticetes. Powdered baleen samples were recovered from single specimens of North Atlantic right, bowhead, blue (Balaenoptera [B...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/29219045/mitochondrial-genetic-diversity-and-phylogeography-of-mus-musculus-castaneus-in-northern-punjab-pakistan
#6
Shahnaz Bibi, Muhammad Sajid Nadeem, Andrew Stephen Wiewel, Mirza Azhar Beg, Khalid Hameed, Musarrat Jabeen, Ghazala Kaukab Raja
Regions of Iran, Afghanistan, Pakistan and northwestern India have been proposed as the place of origin of Mus musculus castaneus. But despite the fact that Pakistan encompasses an important part of its range, M. m. castaneus populations in Pakistan have not been the subject of intensive genetic and biogeographic studies, except for a very small number of samples included in past studies. We studied genetic variation in M. m. castaneus (CAS) from northern Punjab Province, Pakistan, by using cytochrome b (Cytb) analysis in a sample of 98 individuals...
December 2017: Zoological Science
https://www.readbyqxmd.com/read/29199946/stimulation-of-hair-follicle-stem-cell-proliferation-through-an-il-1-dependent-activation-of-%C3%AE-%C3%AE-t-cells
#7
Pedro Lee, Rupali Gund, Abhik Dutta, Neha Pincha, Isha Rana, Subhasri Ghosh, Deborah Witherden, Eve Kandyba, Amanda MacLeod, Krzysztof Kobielak, Wendy L Havran, Colin Jamora
The cutaneous wound-healing program is a product of a complex interplay among diverse cell types within the skin. One fundamental process that is mediated by these reciprocal interactions is the mobilization of local stem cell pools to promote tissue regeneration and repair. Using the ablation of epidermal caspase-8 as a model of wound healing in Mus musculus, we analyzed the signaling components responsible for epithelial stem cell proliferation. We found that IL-1α and IL-7 secreted from keratinocytes work in tandem to expand the activated population of resident epidermal γδT-cells...
December 4, 2017: ELife
https://www.readbyqxmd.com/read/29199466/toxicological-evaluation-in-silico-and-in-vivo-of-secondary-metabolites-of-cissampelos-sympodialis-in-mus-musculus-mice-following-inhalation
#8
Mateus Feitosa Alves, Larissa Adilis Maria Paiva Ferreira, Francisco Allysson Assis Ferreira Gadelha, Laércia Karla Diega Paiva Ferreira, Mayara Barbalho Felix, Marcus Tullius Scotti, Luciana Scotti, Kardilândia Mendes de Oliveira, Sócrates Golzio Dos Santos, Margareth de Fátima Formiga Melo Diniz
The ethanolic extract of the leaves of Cissampelos sympodialis showed great pharmacological potential, with inflammatory and immunomodulatory activities, however, it showed some toxicological effects. Therefore, this study aims to verify the toxicological potential of alkaloids of the genus Cissampelos through in silico methodologies, to develop a method in LC-MS/MS verifying the presence of alkaloids in the infusion and to evaluate the toxicity of the infusion of the leaves of C. sympodialis when inhaled by Swiss mice...
December 4, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29196872/seleno-compounds-and-carnosic-acid-added-to-diets-with-rapeseed-and-fish-oils-affect-concentrations-of-selected-elements-and-chemical-composition-in-the-liver-heart-and-muscles-of-lambs
#9
Marian Czauderna, Anna Ruszczyńska, Ewa Bulska, Katarzyna Agnieszka Krajewska
The objective of our studies was to investigate effects of carnosic acid (CA), selenized yeast (SeY) and selenate (SeVI) added to the diet including rapeseed oil (RO) and fish oil (FO) on concentrations of elements, fatty acids (FAs), tocopherols, cholesterol, and malondialdehyde in the liver, heart, musculus longissimus dorsi (MLD), and musculus biceps femoris (MBF) of lambs. Lambs were fed diets: group I-the basal diet (BD) with RO; group II-BD with RO and FO; group III-BD with RO, FO, and CA; group IV-BD with RO, FO, CA, and SeY; group V-BD with RO, FO, CA, and SeVI...
December 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29193268/what-role-does-heritability-play-in-transgenerational-phenotypic-responses-to-captivity-implications-for-managing-captive-populations
#10
Stephanie K Courtney Jones, Phillip G Byrnea
Animals maintained in captivity exhibit rapid changes in phenotypic traits, which may be maladaptive for natural environments. The phenotype can shift away from the wild phenotype via transgenerational effects, with the environment experienced by parents influencing the phenotype and fitness of offspring. There is emerging evidence that controlling transgenerational effects could help mitigate the effects of captivity, improving the success of captively bred animals post release. However, controlling transgenerational effects requires knowledge of the mechanisms driving transgenerational changes...
November 28, 2017: Zoo Biology
https://www.readbyqxmd.com/read/29192336/identification-of-opossums-didelphis-aurita-wied-neuweid-1826-as-a-definitive-host-of-sarcocystis-falcatula-like-sporocysts
#11
Samira Salim Mello Gallo, David Scott Lindsay, Nicole Brand Ederli, Filipe Pereira Matteoli, Thiago Motta Venancio, Francisco Carlos Rodrigues de Oliveira
This study was conducted to identify the Sarcocystis species that infect the opossum Didelphis aurita in order to determine which sporocysts they are excreating in to the environment and help determine the role of D. aurita in the epidemiology of Sarcocystis. Sporocysts were obtained from intestinal tracts of 8 of 13 D. aurita trapped in Rio de Janeiro state, Brazil, and were orally inoculated into Melopsittacus undulatus and Balb/c nude Mus musculus. Portions of organs and muscles were processed for histology, immunohistochemistry, transmission electron microscopy (TEM), and PCR using primers JNB 33/54, and ITS...
December 1, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29189940/the-relationship-between-dietary-protein-content-body-condition-and-%C3%AE-15n-in-a-mammalian-omnivore
#12
Kelli L Hughes, John P Whiteman, Seth D Newsome
Seasonal reductions in food availability may cause animals to catabolize endogenous tissue and the resulting loss of lean mass can hinder their ability to forage and reproduce. While several studies have considered nitrogen isotopes (δ15N) as an indicator of catabolism, relationships between protein intake, body condition, and tissue δ15N have not been assessed simultaneously in controlled conditions. We conducted a feeding experiment on laboratory mice (Mus musculus) to test the effects of low (5%) versus high (30-40%) dietary protein content on lean mass, fat mass, and tissue δ15N...
November 30, 2017: Oecologia
https://www.readbyqxmd.com/read/29187420/bayesian-diallel-analysis-reveals%C3%A2-mx1-dependent-and%C3%A2-mx1-independent-effects-on-response-to-influenza-a-virus-in-mice
#13
Paul L Maurizio, Martin T Ferris, Gregory R Keele, Darla R Miller, Ginger D Shaw, Alan C Whitmore, Ande West, Clayton R Morrison, Kelsey E Noll, Kenneth S Plante, Adam S Cockrell, David W Threadgill, Fernando Pardo-Manuel de Villena, Ralph S Baric, Mark T Heise, William Valdar
Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but this host genetic architecture is not well understood. Here we obtain a broad view of how heritable factors affect a mouse model of response to IAV infection using an 8×8 diallel of the eight inbred founder strains of the Collaborative Cross (CC). Expanding on a prior statistical framework for modeling treatment response in diallels, we explore how a range of heritable effects modify acute host response to IAV through 4 days post-infection...
November 29, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29173547/bobcats-lynx-rufus-are-natural-definitive-host-of-besnoitia-darlingi
#14
Shiv K Verma, Camila K Cerqueira-Cézar, Fernando H A Murata, Matthew J Lovallo, Benjamin M Rosenthal, Jitender P Dubey
Bovine besnoitiosis, caused by Besnoitia besnoiti, is an economically important disease of cattle in many countries but its transmission remains a mystery. Wild felids are suspected to be its definitive hosts. The domestic cat (Felis catus) is known experimental definitive host for Besnoitia species of rodents. Here, we report for Besnoitia darlingi the first identification of a natural definitive host, the bobcat (Lynx rufus). Oocysts resembling Toxoplasma gondii (unsporulated; 10.9±0.8×12.1±0.2μm; n=5) were detected microscopically in the feces of two of 25 free ranging wild bobcats from Mississippi, USA...
December 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29173281/akt-isoforms-have-distinct-hippocampal-expression-and-roles-in-synaptic-plasticity
#15
Josien Levenga, Helen Wong, Ryan A Milstead, Bailey N Keller, Lauren E LaPlante, Charles A Hoeffer
AKT is a kinase regulating numerous cellular processes in the brain and mutations in AKT are known to affect brain function. AKT is indirectly implicated in synaptic plasticity, but its direct role has not been studied. Moreover, three highly related AKT isoforms are expressed in the brain, but their individual roles are poorly understood. We find in Mus musculus, each AKT isoform has a unique expression pattern in the hippocampus, with AKT1 and AKT3 primarily in neurons but displaying local differences, while AKT2 is in astrocytes...
November 27, 2017: ELife
https://www.readbyqxmd.com/read/29171448/vitamin-d-cell-death-pathways-and-tuberculosis
#16
Manik Retno Wahyunitisari, Ni Made Mertaniasih, Muhammad Amin, Wayan T Artama, Eko B Koendhori
BACKGROUND: Mycobacterium tuberculosis induces cellular necrosis that could promote spread of infection. The aim of this study is to analyze the effects of Vitamin D3 supplementation to improve the effectiveness of 2nd-line anti-tuberculosis (TB) drug therapy, especially in relation with cell death pathways. METHODS: Mus musculus C3HeB/FeJ was randomly divided into four groups containing eight animals each. The 1st group (G1), consisting of mice that were intratracheally infected with multidrug-resistant strain of M...
October 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29169618/clinical-pathology-of-the-vulnerable-gough-moorhen-gallinula-comeri
#17
M P Dagleish, P G Ryan, S Girling, M Ghazali, A L Bond
The Gough moorhen (Gallinula comeri) is native to Gough Island, Tristan da Cunha, and listed as Vulnerable by the International Union for Conservation of Nature due to its restricted range and susceptibility to introduced predators. A planned ecosystem restoration by eradication of introduced house mice (Mus musculus) via aerially delivered rodenticide requires a reproductively balanced population of Gough moorhens to be held in captivity to avoid primary and secondary poisoning. To aid disease detection during the period of captivity, Gough moorhens (n = 43; 25 adult females and 18 adult males) were captured, measured and sampled to determine ease of sexing by morphometrics, to establish reference ranges for routine haematological and biochemical parameters and to identify any intestinal and haemoparasites as well as determine which faecal bacteria were present...
November 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29167345/merkel-cell-polyomavirus-infection-of-animal-dermal-fibroblasts
#18
Wei Liu, Nathan A Krump, Margo MacDonald, Jianxin You
Merkel cell polyomavirus (MCPyV) is the first polyomavirus to be associated with human cancer. Mechanistic studies attempting to fully elucidate MCPyV oncogenic mechanisms have been hampered by the lack of animal models for MCPyV infection. In this study, we examined the infectability of MCPyV-GFP pseudovirus, MCPyV recombinant virion, and several MCPyV chimeric viruses in dermal fibroblasts isolated from various model animals, including mouse (Mus musculus), rabbit (Oryctolagus cuniculus), rat (Rattus norvegicus), chimpanzee (Pan troglodytes), rhesus macaque (Macaca mulatta), patas monkey (Erythrocebus patas), common woolly monkey (Lagothrix lagotricha), red-chested mustached tamarin (Saguinus labiatus), and tree shrew (Tupaia Belangeri)...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29166657/the-effects-of-kinesio-taping-on-the-trajectory-of-the-forelimb-and-the-muscle-activity-of-the-musculus-brachiocephalicus-and-the-musculus-extensor-carpi-radialis-in-horses
#19
Antonia Zellner, Barbara Bockstahler, Christian Peham
BACKGROUND INFORMATION: The present study aimed to investigate the effects of Kinesio Taping on the trajectory of the forelimb and the muscle activity of the M. brachiocephalicus and the M. extensor carpi radialis in horses. 19 horses and ponies of different breeds (body weight: 496±117 kg), gender (8 mares, 10 geldings and 3 stallions) and ages (14.9±6.9 years old) were analysed without Kinesio Tape ("no tape"), with Kinesio Tape (muscle facilitation application on both muscles of both sides, "with tape") and immediately after Kinesio Taping ("post tape") through kinematic motion analysis and surface electromyography on a treadmill at the walk (speed: 1...
2017: PloS One
https://www.readbyqxmd.com/read/29158335/a-deconvolution-protocol-for-chip-seq-reveals-analogous-enhancer-structures-on-the-mouse-and-human-ribosomal-rna-genes
#20
Jean-Clement Mars, Marianne Sabourin-Felix, Michel G Tremblay, Tom Moss
The combination of Chromatin Immunoprecipitation and Massively Parallel Sequencing, or ChIP-Seq, has greatly advanced our genome-wide understanding of chromatin and enhancer structures. However, its resolution at any given genetic locus is limited by several factors. In applying ChIP-Seq to the study of the ribosomal RNA genes, we found that a major limitation to resolution was imposed by the underlying variability in sequence coverage that very often dominates the protein-DNA interaction profiles. Here we describe a simple numerical deconvolution approach that in large part corrects for this variability and significantly improves both the resolution and quantitation of protein-DNA interaction maps deduced from ChIP-Seq data...
November 20, 2017: G3: Genes—Genomes—Genetics
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