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https://www.readbyqxmd.com/read/29661036/when-migraine-mimics-stroke-a-systematic-review
#1
Alberto Terrin, Giulia Toldo, Mario Ermani, Federico Mainardi, Ferdinando Maggioni
Background Migraine with aura may mimic an acute ischemic stroke, so that an improper administration of thrombolytic treatment can expose migrainous patients to severe adverse effects. Methods This systematic review quantifies the relevance of migraine with aura among stroke mimics, checking for thrombolysis' safety in these patients. We reviewed the literature after 1995, distinguishing from studies dealing with stroke mimics treated with systemic thrombolysis and those who were not treated with systemic thrombolysis...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29655808/impact-of-syncope-and-pre-syncope-on-short-term-mortality-in-patients-with-acute-pulmonary-embolism
#2
Loris Roncon, Marco Zuin, Franco Casazza, Cecilia Becattini, Claudio Bilato, Pietro Zonzin
BACKGROUND: Syncope and pre-syncope are well-known symptoms of acute pulmonary embolism (PE). However, data about their impact on short-term mortality are scant. We assess the short-term mortality (30-day) for all-causes in PE patients admitted with syncope or with pre-syncope, according their hemodynamic status at admission. METHODS: Patients from the prospective Italian Pulmonary Embolism Registry (IPER) were included in the study. At admission, subjects were stratified according to 2008 ESC guidelines (as high- and non-high-risk patients)...
April 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29651371/tenecteplase-versus-alteplase-for-the-management-of-acute-ischemic-stroke-in-a-low-income-country-nepal-cost-efficacy-and-safety
#3
REVIEW
Gaurav Nepal, Ghanshyam Kharel, Shaik Tanveer Ahamad, Babin Basnet
Intravenous alteplase is the only approved treatment for acute ischemic stroke. Tenecteplase, a genetically engineered, mutant tissue plasminogen activator, is an alternative thrombolytic agent. The economic feasibility of stroke treatment has been a matter of huge debate and discussion thus far. The use of thrombolytics for the management of ischemic stroke has recently begun in Nepal. In low-income countries like Nepal, where the per capita income falls at just $691.7 and 25.2% of the population are under the poverty line, stroke patients cannot meet treatment expenses...
February 9, 2018: Curēus
https://www.readbyqxmd.com/read/29627022/hyperglycemia-predicts-unfavorable-outcomes-in-acute-ischemic-stroke-patients-treated-with-intravenous-thrombolysis-among-a-chinese-population-a-prospective-cohort-study
#4
Sheng-Feng Lin, A-Ching Chao, Han-Hwa Hu, Ruey-Tay Lin, Chih-Hung Chen, Lung Chan, Huey-Juan Lin, Yu Sun, Yung-Yang Lin, Po-Lin Chen, Shinn-Kuang Lin, Ming-Hui Sun, Cheng-Yu Wei, Yu-Te Lin, Jiunn-Tay Lee, Chi-Huey Bai
BACKGROUND AND PURPOSE: Poorly controlled blood glucose was reported to cause deterioration of acute ischemic stroke. In this study, we investigated whether an elevated admission serum glucose level in the 3-h time window of intravenous thrombolysis for acute ischemic stroke determined poor functional outcomes among Chinese population. METHODS: This was a prospective cohort study. From December 1, 2004 to December 31, 2016, a total of 2370 patients were enrolled and categorized into two cohorts by blood glucose levels of ≥200 and <200 mg/dl in the 3 h after stroke onset...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29623912/cerebral-ischemia-and-neuroregeneration
#5
REVIEW
Reggie H C Lee, Michelle H H Lee, Celeste Y C Wu, Alexandre Couto E Silva, Harlee E Possoit, Tsung-Han Hsieh, Alireza Minagar, Hung Wen Lin
Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies against stroke/cerebral ischemia are urgently needed...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29614907/haemodialysis-access-thrombosis-outcomes-after-surgical-thrombectomy-versus-catheter-directed-thrombolytic-infusion
#6
Linn Koraen-Smith, Matteus Krasun, Matteo Bottai, Ulf Hedin, Carl M Wahlgren, Peter Gillgren
INTRODUCTION: Thrombosis is one of the most common complications of dialysis vascular access and is a significant source of morbidity and healthcare-associated costs. In this retrospective study, outcomes for surgical thrombectomy and thrombolysis after access thrombosis in patients with arteriovenous fistulas or prosthetic grafts (arteriovenous grafts) were analysed. METHODS: All patients with a primary episode of dialysis access thrombosis between 2005 and 2013 were included which yielded 131 patients with 149 episodes of access thrombosis (108 arteriovenous grafts; 41 arteriovenous fistulas)...
April 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29604912/purification-and-antithrombotic-potential-of-a-fibrinolytic-enzyme-from-shiitake-culinary-medicinal-mushroom-lentinus-edodes-gna01-agaricomycetes
#7
Jun-Hui Choi, Kyung-Je Kim, Seung Kim
We purified Lentinus edodes GNA01 fibrinolytic enzyme (LEFE) and identified it as a novel metalloprotease. LEFE was purified to homogeneity through a 2-step procedure, with an 8.28-fold increase in specific activity and 5.3% recovery. The molecular mass of LEFE was approximately 38 kDa, based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Its optimal pH, optimal temperature, pH stability, and thermal stability were 5, 30°C, 6-7, and 40°C, respectively. LEFE was inhibited by zinc and magnesium ions, and by EDTA and EGTA, indicating that LEFE is a metalloprotease...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29590200/retrospective-harm-benefit-analysis-of-pre-clinical-animal-research-for-six-treatment-interventions
#8
Pandora Pound, Christine J Nicol
BACKGROUND: The harm benefit analysis (HBA) is the cornerstone of animal research regulation and is considered to be a key ethical safeguard for animals. The HBA involves weighing the anticipated benefits of animal research against its predicted harms to animals but there are doubts about how objective and accountable this process is. OBJECTIVES: i. To explore the harms to animals involved in pre-clinical animal studies and to assess these against the benefits for humans accruing from these studies; ii...
2018: PloS One
https://www.readbyqxmd.com/read/29589328/influence-of-bleeding-pattern-on-ischemic-lesions-after-spontaneous-hypertensive-intracerebral-hemorrhage-with-intraventricular-hemorrhage
#9
Lucia Rivera-Lara, Santosh B Murthy, Saman Nekoovaght-Tak, Hasan Ali, Nichol McBee, Rachel Dlugash, Malathi Ram, Richard Thompson, Issam A Awad, Daniel F Hanley, Wendy C Ziai
BACKGROUND: Concomitant acute ischemic lesions are detected in up to a quarter of patients with spontaneous intracerebral hemorrhage (ICH). Influence of bleeding pattern and intraventricular hemorrhage (IVH) on risk of ischemic lesions has not been investigated. METHODS: Retrospective study of all 500 patients enrolled in the CLEAR III randomized controlled trial of thrombolytic removal of obstructive IVH using external ventricular drainage. The primary outcome measure was radiologically confirmed ischemic lesions, as reported by the Safety Event Committee and confirmed by two neurologists...
March 27, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29587638/cerebral-microbleeds-shouldn-t-dictate-treatment-of-acute-stroke-a-retrospective-cohort-study-evaluating-risk-of-intracerebral-hemorrhage
#10
Martin A Chacon-Portillo, Rafael H Llinas, Elisabeth B Marsh
BACKGROUND: Intravenous tissue plasminogen activator (IV tPA) after acute ischemic stroke carries the risk of symptomatic intracerebral hemorrhage (sICH). Cerebral microbleeds (CMBs) may indicate increased risk of hemorrhage and can be seen on magnetic resonance imaging (MRI). In this study, we examined the association between CMBs and sICH, focusing on the predictive value of their presence, burden, and location. METHODS: Records from all patients presenting to two academic stroke centers with acute ischemic stroke treated with IV tPA over a 5-year period were retrospectively reviewed...
March 27, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29587253/early-and-one-year-outcomes-of-acute-stroke-in-the-industrial-region-of-poland-during-the-decade-2006-2015-the-silesian-stroke-registry
#11
Marek Gierlotka, Beata Labuz-Roszak, Bogdan Wojtyniak, Anetta Lasek-Bal, Tomasz Zdrojewski, Monika Adamczyk-Sowa, Kamil Chwojnicki, Michal Skrzypek, Daniel Ciesla, Mariusz Gasior
BACKGROUND: Poland, classified as a high-income country, is still considered to have a high cardiovascular risk population. During the last decade, the standards of care in acute stroke (AS) had markedly improved; thus, we aimed to assess whether and how it translated into early and late outcomes. METHODS: Silesian Stroke Registry was created from the administrative database of the public, obligatory, health -insurer in Poland. The AS cases were selected based on primary diagnosis coded in ICD-10 as I60-I64 for years 2006-2015 (n = 120,844)...
March 27, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29567899/autopsy-findings-in-an-atypical-case-of-occult-massive-fatal-pulmonary-embolism-in-a-backdrop-of-hyperhomocysteinemia
#12
Pratibha Misra, Arijit Kumar Ghosh, Aneeta Jassar
A 43-year-old apparently healthy male presented with fever and presyncope. He was suspected to have massive pulmonary thromboembolism based on the clinico-biochemical profile. Despite aggressive thrombolytic therapy, he succumbed to his illness within 12 h of admission. Postmortem examination showed massive pulmonary thromboembolism and hyperhomocysteinemia with low high-density lipoproteins (HDL) cholesterol with antemortem blood sample. Herein, we report autopsy findings in a rare case of a young male with occult massive pulmonary thromboembolism without deep vein thrombosis, who had an atypical clinical presentation and was found to have underlying hyperhomocysteinemia and decreased HDLc...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29565510/analysis-of-related-factors-of-orolingual-angioedema-after-rt-pa-intravenous-thrombolytic-therapy
#13
Y-X Wang, Y-Q Li, Y Chen, C-H Zhang, Z Dong, Z Wang, S-N Zhao, C-H Li, P-L Zhang
OBJECTIVE: Orolingual angioedema (OA) is a rare clinical complication with a potentially fatal risk that occurs after the intravenous application of alteplase (rt-PA) in patients with acute ischemic stroke. The purpose of this work is to investigate the related factors of OA in patients with acute ischemic stroke after the administration of intravenous thrombolytic therapy, to improve the predictive ability of OA during intravenous thrombolytic therapy, and to reduce the prevalence of complications...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29564977/transcranial-near-infrared-laser-therapy-in-improving-cognitive-recovery-of-function-following-traumatic-brain-injury
#14
Xiyang Yao, Chenglin Liu, Dongxia Feng, Jun Yin, Gang Chen
Traumatic brain injury (TBI) is turned into a major health and socioeconomic problem affecting young people and military personnel. Numerous TBI patients experienced the sequela of brain injury called cognitive impairment, which reduced functions in attention, working memory, motivation, and execution. In recent years, transcranial near-infrared laser therapy (tNiRLT) as a possible therapy gradually applied in treating cognitive impairment post-TBI. In the present review, the biological mechanisms of transcranial tNiRLT for TBI are synthesized mainly based on the photonic impact to chronic mild TBI...
April 13, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29562788/retrievable-inferior-vena-cava-filter-utilization-in-obstetric-patients
#15
Amihai Rottenstreich, Yosef Kalish, Uriel Elchalal, Alexander Klimov, Allan I Bloom
OBJECTIVES: To evaluate patterns of use and outcomes of retrievable inferior vena cava filters (rIVCF) in obstetric patients. METHODS: A single center review of consecutive patients who underwent rIVCF placement during pregnancy/postpartum in 2005-2016. A pooled analysis of the relevant cases in the English literature was conducted. RESULTS: The current cohort comprised 24 women, median age 27 [interquartile range 24-30] years. Among 10 filters placed during pregnancy, the most common indication (n = 4) was the need to withhold anticoagulation therapy before delivery, in the presence of acute thrombosis...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29561531/regional-anesthesia-in-the-patient-receiving-antithrombotic-or-thrombolytic-therapy-american-society-of-regional-anesthesia-and-pain-medicine-evidence-based-guidelines-fourth-edition
#16
Terese T Horlocker, Erik Vandermeuelen, Sandra L Kopp, Wiebke Gogarten, Lisa R Leffert, Honorio T Benzon
No abstract text is available yet for this article.
April 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29561530/regional-anesthesia-in-the-patient-receiving-antithrombotic-or-thrombolytic-therapy-if-only-the-data-were-produced-in-a-river-not-a-pond
#17
EDITORIAL
F Kayser Enneking, Marc A Huntoon
No abstract text is available yet for this article.
April 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29555397/thrombolytic-therapy-in-severe-cardioembolic-stroke-after-reversal-of-dabigatran-with-idarucizumab-case-report-and-literature-review
#18
Yuichiro Ohya, Noriko Makihara, Kayo Wakisaka, Takao Morita, Tetsuro Ago, Takanari Kitazono, Hitonori Takaba
Whether idarucizumab, an antidote of dabigatran, can be used effectively and safely before thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) in patients with stroke undergoing treatment with dabigatran remains unknown. We herein describe a 57-year-old man who developed severe cardioembolic stroke with a National Institutes of Health Stroke Scale score of 22 in the left middle cerebral artery territory while undergoing treatment with dabigatran for nonvalvular atrial fibrillation and who was treated with rt-PA after the reversal of dabigatran with idarucizumab...
March 16, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29553456/ischaemic-stroke-management-at-al-shifa-hospital-in-the-gaza-strip-a-clinical-audit
#19
Amir Abukaresh, Rami Al-Abadlah, Bettina Böttcher, Khamis El-Essi
BACKGROUND: In the 2014 Palestinian annual health report, cerebrovascular accident was ranked as the third leading cause of death in the occupied Palestinian territory. Cerebrovascular accident is also one the most common causes of disability worldwide. Good management decreases mortality and morbidity. The aim of this study was to assess the current management of patients with ischaemic stroke at the Al-Shifa Hospital and to compare this with international guidelines. METHODS: For this clinical audit, we used simple random sampling to select files of patients admitted with the diagnosis of ischaemic stroke to the Al-Shifa Hospital...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29553426/management-of-acute-ischaemic-stroke-at-nasser-hospital-gaza-strip-a-clinical-audit
#20
Mohammed N Alkhatib, Tamer Abd-Alghafoor, AlaaEldeen Elmassry, Loai Albarqouni, Bettina Böttcher, Maha Alfaqawi
BACKGROUND: Stroke is a leading cause of morbidity and mortality worldwide. The aim of this study was to assess the standard of care for patients with acute ischaemic stroke at the internal medicine department of Nasser Hospital, Gaza Strip. METHODS: For this retrospective clinical audit, we selected a random sample of 100 medical records for patients with stroke who were admitted to Nasser Hospital between January and August, 2016. Clinical practice was compared with the recommendations in the 2013 American Heart Association and American Stroke Association guidelines...
February 21, 2018: Lancet
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