keyword
MENU ▼
Read by QxMD icon Read
search

Thrombolytic

keyword
https://www.readbyqxmd.com/read/29445287/patient-knowledge-on-stroke-risk-factors-symptoms-and-treatment-options
#1
Kashif Waqar Faiz, Antje Sundseth, Bente Thommessen, Ole Morten Rønning
Background: Public campaigns focus primarily on stroke symptom and risk factor knowledge, but patients who correctly recognize stroke symptoms do not necessarily know the reason for urgent hospitalization. The aim of this study was to explore knowledge on stroke risk factors, symptoms and treatment options among acute stroke and transient ischemic attack patients. Methods: This prospective study included patients admitted to the stroke unit at the Department of Neurology, Akershus University Hospital, Norway...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29419626/effect-of-a-patency-bundle-on-central-venous-catheter-complications-among-hospitalized-adult-patients-a-best-practice-implementation-project
#2
Vivian Huang
OBJECTIVES: The aim of this project was to improve continuity of care by decreasing central catheter occlusions in adults in two acute care units with high use of central venous catheters. Specific objectives were to introduce a patency bundle and train nurses on thrombolytic administration for timely resolution of catheter occlusions. INTRODUCTION: Central venous catheters are a vital component of medical care of acutely ill hospitalized patients. Occluded catheters delay treatment and can increase infection risk...
February 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29417839/mechanical-thrombectomy-is-time-still-brain-the-dawn-of-a-new-era
#3
Naveed Kamal, Neil Majmundar, Nitesh Damadora, Mohammad El-Ghanem, Rolla Nuoman, Irwin A Keller, Steven Schonfeld, Igor Rybinnik, Gaurav Gupta, Sudipta Roychowdry, Fawaz Al-Mufti
PURPOSE: The purpose of this study is to review the history of treatments for acute ischemic stroke, examine developments in endovascular therapy, and discuss the future of the management of acute ischemic stroke. METHODS: A selective review of recent clinical trials for the treatment of acute ischemic stroke was conducted. RESULTS: We reviewed completed trials of the management of acute ischemic stroke including intravenous thrombolytics, intraarterial thrombolytics, and thrombectomy...
February 8, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29416997/acute-coronary-syndrome-related-mortality-audit-in-a-teaching-hospital-at-port-blair-india
#4
Shiv Shankar Singh, Swapan Kumar Paul, Ranabir Pal, Pandurang Vithal Thatkar
Background: India has a growing trend of acute myocardial infarction (AMI) due to shifting lifestyle. Objective: To study the profile of patients died due to AMI and to find its risk correlates. Methods: A study was conducted on consecutive AMI cases admitted in the teaching hospital at Port Blair from April 2011 to March 2016. During inpatients management, outcomes were followed up from admission till discharge or expiry. Results: Of the total 491 cases, majority (75...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29415308/clinical-information-systems-integration-in-new-york-city-s-first-mobile-stroke-unit
#5
Benjamin R Kummer, Michael P Lerario, Babak B Navi, Adam C Ganzman, Daniel Ribaudo, Saad A Mir, Sammy Pishanidar, Tim Lekic, Olajide Williams, Hooman Kamel, Randolph S Marshall, George Hripcsak, Mitchell S V Elkind, Matthew E Fink
BACKGROUND:  Mobile stroke units (MSUs) reduce time to thrombolytic therapy in acute ischemic stroke. These units are widely used, but the clinical information systems underlying MSU operations are understudied. OBJECTIVE:  The first MSU on the East Coast of the United States was established at New York Presbyterian Hospital (NYP) in October 2016. We describe our program's 7-month pilot, focusing on the integration of our hospital's clinical information systems into our MSU to support patient care and research efforts...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29412186/cyclic-rgd-functionalized-liposomes-encapsulating-urokinase-for-thrombolysis
#6
Nengpan Zhang, Chunlin Li, Dayong Zhou, Chen Ding, Yaqing Jin, Qingmei Tian, Xiangzhou Meng, Kefeng Pu, Yimin Zhu
Thrombosis, a critical event in blood vessels, not only is associated with myocardial infarction and stroke, but also accounts for considerable morbidity and mortality. Thrombolytic drugs are usually applied to the treatment of acute myocardial infarction, acute cerebral infarction and pulmonary embolism. However, thrombolytic drugs show limited efficacy in clinical practice because of the short half-life in plasma and systemic side effects. In this study, the cyclic RGD (cRGD) functionalized liposomes were prepared to encapsulate urokinase, a cheap and widely used thrombolytic drug in clinic and better thrombolysis efficacy was achieved...
February 2, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29407893/atherosclerotic-intracranial-internal-carotid-artery-calcification-and-intravenous-thrombolytic-therapy-for-acute-ischemic-stroke
#7
Rahsan Gocmen, Ethem Murat Arsava, Kader Karli Oguz, Mehmet Akif Topcuoglu
BACKGROUND AND AIMS: Intracranial internal carotid artery calcification (IICAC) is a frequent and readily available finding in acute stroke patients treated with intravenous (IV) tissue plasminogen activator (tPA). We aimed to investigate the effects of IICAC subtype (medial and intimal) on the response to IV tPA. METHODS: In this retrospective study, 91 (57% female, age 69 ± 13 years) consecutive acute anterior circulation stroke patients treated with IV tPA were included...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29404353/simultaneous-acute-cardio-cerebral-infarction-is-there-a-consensus-for-management
#8
REVIEW
Oluwaseun A Akinseye, Muhammad Shahreyar, Mark R Heckle, Rami N Khouzam
Acute ischemic stroke (AIS) and acute myocardial infarction (AMI) are both life-threatening medical conditions with narrow therapeutic time-window that carry grave prognosis if not addressed promptly. The acute management of both condition is well documented in the literature, however the management of a simultaneous presentation of both AIS and AMI is unclear. A delayed intervention of one infarcted territory for the other may result in permanent irreversible morbidity or disability, and even death. In addition, the use of antiplatelet and anticoagulants that are inherently part of an AMI management may increase the risk for hemorrhagic conversion associated with intravenous thrombolysis used in AIS, and the use of a thrombolytic in AIS increases the risk of cardiac wall rupture in the setting of an AMI...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29404166/does-the-incidence-and-mortality-of-pulmonary-thromboembolism-change-over-the-years
#9
Savaş Sedat Özsu, Zerrin Gürel Durmuş, Mustafa Buğra Coşkuner, Yılmaz Bülbül, Funda Öztuna, Tevfik Özlü
OBJECTIVES: In the last 20 years, with the use of computed tomography (CT) angiography, the number of patients diagnosed with pulmonary thromboembolism (PTE) has increased. At the same time, data show that pulmonary embolism mortality has also reduced in this duration. MATERIAL AND METHODS: In this study, we analyzed records of patients with PTE (using ICD's) in the hospital automation system from 2001 to 2013. Data regarding age, sex, date of diagnosis, diagnosis of cancer, hemodynamic status, initial and maintenance treatment, hospital length of stay, and hospital mortality were recorded...
July 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29399526/catheter-directed-thrombolysis-of-deep-vein-thrombosis-literature-review-and-practice-considerations
#10
REVIEW
Drew Fleck, Hassan Albadawi, Fadi Shamoun, Grace Knuttinen, Sailendra Naidu, Rahmi Oklu
Deep vein thrombosis (DVT) is a major health problem worldwide. The risk of pulmonary embolism following DVT is well established, but the long-term vascular sequelae of DVT are often underappreciated, costly to manage, and can have extremely detrimental effects on quality of life. Treatment of DVT classically involves oral anticoagulation, which reduces the risk of pulmonary embolism but does not remove the clot. Anticoagulation therefore does little to prevent the venous damage and scarring that occurs following DVT, leaving the patient at risk for permanent venous insufficiency and development of post-thrombotic syndrome (PTS)...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29399523/animal-models-of-venous-thrombosis
#11
REVIEW
Hassan Albadawi, Avery A Witting, Yash Pershad, Alex Wallace, Andrew R Fleck, Peter Hoang, Ali Khademhosseini, Rahmi Oklu
Venous thrombosis (VT) is a prevalent clinical condition with significant adverse sequela or mortality. Anticoagulation and pharmacologic or pharmacomechanical thrombolytic therapies are the mainstays of VT treatment. An understanding of thrombosis biology will allow for more effective VT-tailored diagnosis and therapy. In vivo models of thrombosis provide indispensable tools to study the pathogenesis of thrombus formation and to evaluate novel therapeutic or preventive adjuncts for VT management or prevention...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29399522/can-thrombus-age-guide-thrombolytic-therapy
#12
REVIEW
Christopher Czaplicki, Hassan Albadawi, Sasan Partovi, Ripal T Gandhi, Keith Quencer, Amy R Deipolyi, Rahmi Oklu
Venous thrombosis (VT) is a common yet complex clinical condition that has shown minimal alteration in clinical management for decades. It is well known that thrombus evolves structurally over time, with complex changes resulting from the interplay between coagulation factors, cytokines, leukocytes and a myriad of other factors. Our current treatment options are most effective in the acute thrombus, which is composed predominantly of a loose mesh of fibrin and red blood cells (RBCs), making current anticoagulation therapies and thrombolytics quite effective in treatment...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29399075/impact-of-collateral-circulation-status-on-favorable-outcomes-in-thrombolysis-treatment-a-systematic-review-and-meta-analysis
#13
Alimu Wufuer, Atikaimu Wubuli, Peierdun Mijiti, Jun Zhou, Shabier Tuerxun, Jian Cai, Jianhua Ma, Xiaoning Zhang
Collateral circulation affects the prognosis of patients with acute ischemic stroke (AIS) treated by thrombolysis. The present study performed a systematic assessment of the impact of the collateral circulation status on the outcomes of patients receiving thrombolysis treatment. Relevant full-text articles from the Cochrane Library, Ovid, Medline, Embase and PubMed databases published from January 1, 2000 to November 1, 2016 were retrieved. The quality of the studies was assessed and data were extracted by 2 independent investigators...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29398534/thrombolysis-in-large-diffusion-weighted-imaging-lesions-lower-chance-but-still-a-chance
#14
Hyun-Wook Nah, Dae-Hyun Kim, Myongjin Kang, Jae-Hyung Choi, Hyun-Seok Park, Jae-Kwan Cha
BACKGROUND: We sought to investigate whether early thrombolytic treatment can result in favorable functional outcome even in patients with large diffusion-weighted imaging (DWI) lesions. MATERIALS AND METHODS: We analyzed 566 patients who received intravenous alteplase within 4.5 hours from onset, initially underwent DWI and magnetic resonance angiography, and had acute infarction confined to anterior circulation. DWI lesion volumes were measured semiautomatically...
February 2, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29390574/a-case-report-of-parenchymal-hematoma-after-intravenous-thrombolysis-in-a-rivaroxaban-treated-patient-is-it-a-true-rivaroxaban-hemorrhagic-complication
#15
Eugenia Rota, Gianluca Bruzzone, Sergio Agosti, Roberto Pastorino, Nicola Morelli
RATIONALE: To date, the only treatment approved for acute ischemic strokes is thrombolysis. Whether intravenous thrombolysis may be safe in patients taking direct oral anticoagulants (DOACs) is currently a matter of debate. PATIENT CONCERNS: A 74-year-old woman, who was on rivaroxaban 20 mg/d for nonvalvular atrial fibrillation, was admitted to our stroke unit with left-sided hemiparesis and aphasia. The onset of neurologic deficits had occurred 5 hours after the last rivaroxaban dose...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386899/impact-of-intravenous-thrombolysis-on-length-of-hospital-stay-in-cases-of-acute-ischemic-stroke
#16
Narongrit Kasemsap, Nisa Vorasoot, Kannikar Kongbunkiat, Udomlack Peansukwech, Somsak Tiamkao, Kittisak Sawanyawisuth
Background: There are limited data available on factors associated with length of stay (LOS) in cases of acute ischemic stroke according to Poisson analysis, which is more appropriate than other methods. Materials and methods: We retrospectively reviewed medical summary charts of patients with acute ischemic stroke in 30 hospitals across northeast Thailand, with the main outcome as LOS. Poisson regression was used to examine factors associated with LOS. Results: We included 898 patients in the analysis; 460 (51...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29382029/acute-stent-thrombosis-after-stent-assisted-coiling-in-an-intracranial-aneurysm-patient-carrying-two-reduced-function-cyp2c19-alleles-a-case-report
#17
Lanping Ding, Zhichun Gu, Rong Wang, Yichen Li, Yun Fang
RATIONALE: Stent thrombosis (ST) remains a thorny issue in spite of dual antiplatelet treatment with aspirin plus clopidogrel after stent-assisted coiling (SAC). We report a first case of acute ST after SAC in an intracranial aneurysm (IA) patient who carries two reduced-function CYP2C19 alleles. PATIENT CONCERNS: A 43-year-old Chinese male carrying two reduced-function CYP2C19 alleles was treated with a loading dose of clopidogrel 300 mg and aspirin 300 mg before SAC...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29378443/thrombolysis-in-pregnancy-a-literature-review
#18
Marina Sousa Gomes, Mariana Guimarães, Nuno Montenegro
BACKGROUND: Changes in the coagulation system during pregnancy and puerperium produce a physiological hypercoagulable state. These changes are thought to be the cause of the higher rates of deep vein thrombosis, pulmonary embolism, stroke, and mechanical prosthetic valve thrombosis during pregnancy. Thrombolysis can be a treatment option in this cases. However, there are no available data from randomized controlled trials in pregnant patients and information about the security of thrombolytics in pregnancy is missing...
January 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29378380/intra-arterial-thrombolytic-therapy-is-not-a-therapeutic-option-for-filler-related-central-retinal-artery-occlusion
#19
Yi-Chun Chen, Hsiu-Mei Wu, Shin-Jen Chen, Han-Jui Lee, Jiing-Feng Lirng, Chung-Jung Lin, Feng-Chi Chang, Chao-Bao Luo, Wan-Yuo Guo
Cosmetic facial filler-related central retinal artery occlusion (CRAO) is a devastating complication of facial hyaluronic acid (HA) injection and can be managed by intra-arterial thrombolytic therapy (IATT). The authors report on a 20-year-old woman who developed unilateral CRAO due to facial HA injection and who, despite prompt IATT, lost vision. A review of the related literature found 14 other female patients who developed cosmetic facial filler-related CRAO and accepted IATT management. In no case was vision loss clinically improved...
January 29, 2018: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29374642/hemiparesis-in-spontaneous-spinal-epidural-haematoma-a-potential-stroke-imitator
#20
Ravish Patel, Aravind Kumar, Kazuya Nishizawa, Naresh Kumar
Spontaneous spinal epidural haematoma (SSEH) is a rare condition that requires urgent surgical intervention in order to prevent permanent neurological deficit. SSEH commonly presents as a paraparesis or tetraparesis. SSEH presenting as a hemiparesis is less common and in such situations, it can be mistaken for a cerebrovascular accident (CVA). Thrombolytic or anticoagulant treatment for CVA can potentially worsen the neurological deficit. We report one such case of SSEH misdiagnosed as a CVA. Treatment with tissue plasminogen activator led to worsening of his condition...
January 26, 2018: BMJ Case Reports
keyword
keyword
96478
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"