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https://www.readbyqxmd.com/read/27922578/facet-joint-violation-during-percutaneous-pedicle-screw-placement-a-comparison-of-two-techniques
#1
Oliver Tannous, Ehsan Jazini, Tristan B Weir, Kelley E Banagan, Eugene Y Koh, D Greg Anderson, Daniel E Gelb, Steven C Ludwig
STUDY DESIGN: A comparative study of facet joint violation (FJV) using two percutaneous surgical techniques. OBJECTIVE: To compare the rate of iatrogenic FJV and medial pedicle wall breach between two methods of percutaneous pedicle screw instrumentation in the thoracic and lumbar spine. SUMMARY OF BACKGROUND DATA: Variable iatrogenic damage to the facet joints has been reported to occur with percutaneous pedicle screw techniques, compared with the open approach, which has been associated with adjacent segment disease...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27920432/discovery-of-an-enzyme-and-substrate-selective-inhibitor-of-adam10-using-an-exosite-binding-glycosylated-substrate
#2
Franck Madoux, Daniela Dreymuller, Jean-Phillipe Pettiloud, Radleigh Santos, Christoph Becker-Pauly, Andreas Ludwig, Gregg B Fields, Thomas Bannister, Timothy P Spicer, Mare Cudic, Louis D Scampavia, Dmitriy Minond
ADAM10 and ADAM17 have been shown to contribute to the acquired drug resistance of HER2-positive breast cancer in response to trastuzumab. The majority of ADAM10 and ADAM17 inhibitor development has been focused on the discovery of compounds that bind the active site zinc, however, in recent years, there has been a shift from active site to secondary substrate binding site (exosite) inhibitor discovery in order to identify non-zinc-binding molecules. In the present work a glycosylated, exosite-binding substrate of ADAM10 and ADAM17 was utilized to screen 370,276 compounds from the MLPCN collection...
December 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920089/world-endometriosis-society-consensus-on-the-classification-of-endometriosis
#3
Neil P Johnson, Lone Hummelshoj, G David Adamson, Jörg Keckstein, Hugh S Taylor, Mauricio S Abrao, Deborah Bush, Ludwig Kiesel, Rulla Tamimi, Kathy L Sharpe-Timms, Luk Rombauts, Linda C Giudice
STUDY QUESTION: What is the global consensus on the classification of endometriosis that considers the views of women with endometriosis? SUMMARY ANSWER: We have produced an international consensus statement on the classification of endometriosis through systematic appraisal of evidence and a consensus process that included representatives of national and international, medical and non-medical societies, patient organizations, and companies with an interest in endometriosis...
December 5, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27919740/metabolic-differences-between-cold-stored-and-machine-perfused-porcine-kidneys-a-1-h-nmr-based-study
#4
Jay Nath, Tom B Smith, Kamlesh Patel, Sam R Ebbs, Alex Hollis, Daniel A Tennant, Christian Ludwig, Andrew R Ready
Hypothermic machine perfusion (HMP) and static cold storage (SCS) are the two methods used to preserve deceased donor kidneys prior to transplant. This study seeks to characterise the metabolic profile of HMP and SCS porcine kidneys in a cardiac death donor model. Twenty kidneys were cold flushed and stored for two hours following retrieval. Paired kidneys then underwent 24 h of HMP or SCS or served as time zero controls. Metabolite quantification in both storage fluid and kidney tissue was performed using one dimensional (1)H NMR spectroscopy...
December 2, 2016: Cryobiology
https://www.readbyqxmd.com/read/27917914/t-cells-mediate-autoantibody-induced-cutaneous-inflammation-and-blistering-in-epidermolysis-bullosa-acquisita
#5
Katja Bieber, Mareike Witte, Shijie Sun, Jennifer E Hundt, Kathrin Kalies, Sören Dräger, Anika Kasprick, Trix Twelkmeyer, Rudolf A Manz, Peter König, Jörg Köhl, Detlef Zillikens, Ralf J Ludwig
T cells are key players in autoimmune diseases by supporting the production of autoantibodies. However, their contribution to the effector phase of antibody-mediated autoimmune dermatoses, i.e., tissue injury and inflammation of the skin, has not been investigated. In this paper, we demonstrate that T cells amplify the development of autoantibody-induced tissue injury in a prototypical, organ-specific autoimmune disease, namely epidermolysis bullosa acquisita (EBA) - characterized and caused by autoantibodies targeting type VII collagen...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916742/angiographic-and-clinical-outcomes-of-patients-treated-with-drug-coated-balloon-angioplasty-for-in-stent-restenosis-after-coronary-bifurcation-stenting-with-a-two-stent-technique
#6
Yukinori Harada, Roisin Colleran, Susanne Pinieck, Daniele Giacoppo, Jonathan Michel, Sebastian Kufner, Salvatore Cassese, Michael Joner, Tareq Ibrahim, Karl-Ludwig Laugwitz, Adnan Kastrati, Robert A Byrne
AIMS: We conducted this study to evaluate the efficacy of drug-coated balloon therapy for in-stent restenosis after coronary bifurcation stenting. METHODS AND RESULTS: Patients who underwent angioplasty with at least one paclitaxel-coated balloon for in-stent restenosis after bifurcation intervention using a two-stent approach were included. Two types of paclitaxel-coated balloon were used, with either iopromid (iopromide-PCB) or butyryltri-n-hexyl citrate excipient (BTHC-PCB)...
December 6, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27916685/finding-the-right-fit-studying-the-biomechanics-of-under-tapping-with-varied-thread-depth-and-pitch
#7
Ehsan Jazini, Carmen Petraglia, Mark Moldavsky, Oliver Tannous, Tristan Weir, Comron Saifi, Omar Elkassabany, Yiwei Cai, Brandon Bucklen, Joseph O'Brien, Steven C Ludwig
BACKGROUND CONTEXT: Compromise of pedicle screw purchase is a concern in maintaining rigid spinal fixation, especially with osteoporosis. Little consistency exists among various tapping techniques. Pedicle screws are often prepared with taps of a smaller diameter, which can further exacerbate inconsistency. PURPOSE: To determine whether a mismatch between tap thread depth (D) and pitch (P) and screw thread D and P affects fixation when under-tapping in osteoporotic bone...
December 1, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27911496/gram-scale-chemical-synthesis-of-base-modified-ribonucleoside-5-o-triphosphates
#8
Muthian Shanmugasundaram, Annamalai Senthilvelan, Anilkumar R Kore
This unit delineates a simple, reliable, straight-forward, general, and efficient chemical method for the synthesis of modified nucleoside-5'-O-triphosphates such as 5-methylcytidine-5'-O-triphosphate (5-Me-CTP), pseudouridine-5'-O-triphosphate (pseudo-UTP), and N(1) -methylpseudouridine-5'-O-triphosphate (N(1) -methylpseudo-UTP), starting from the corresponding nucleoside. The reaction utilizes an improved protection-free "one-pot, three-step" Ludwig synthetic strategy that involves the monophosphorylation of the nucleoside with phosphorous oxychloride followed by reaction with tributylammonium pyrophosphate and subsequent hydrolysis of the resulting cyclic intermediate to furnish the corresponding ribonucleoside triphosphate (NTP) in moderate yields...
December 1, 2016: Current Protocols in Nucleic Acid Chemistry
https://www.readbyqxmd.com/read/27910197/a-stable-manganese-pincer-catalyst-for-the-selective-dehydrogenation-of-methanol
#9
María Andérez-Fernández, Lydia K Vogt, Steffen Fischer, Wei Zhou, Haijun Jiao, Marcel Garbe, Saravanakumar Elangovan, Kathrin Junge, Henrik Junge, Ralf Ludwig, Matthias Beller
For the first time, structurally defined manganese pincer complexes catalyze the dehydrogenation of aqueous methanol to hydrogen and carbon dioxide, which is a transformation of interest with regard to the implementation of a hydrogen and methanol economy. Excellent long-term stability was demonstrated for the Mn-PNPiPr catalyst, as a turnover of more than 20 000 was reached. In addition to methanol, other important hydrogen carriers were also successfully dehydrogenated.
December 2, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27909000/distinct-contributions-of-dorsal-and-ventral-streams-to-imitation-of-tool-use-and-communicative-gestures
#10
Andrea Dressing, Kai Nitschke, Dorothee Kümmerer, Tobias Bormann, Lena Beume, Charlotte S M Schmidt, Vera M Ludwig, Irina Mader, Klaus Willmes, Michel Rijntjes, Christoph P Kaller, Cornelius Weiller, Markus Martin
Imitation of tool-use gestures (transitive; e.g., hammering) and communicative emblems (intransitive; e.g., waving goodbye) is frequently impaired after left-hemispheric lesions. We aimed 1) to identify lesions related to deficient transitive or intransitive gestures, 2) to delineate regions associated with distinct error types (e.g., hand configuration, kinematics), and 3) to compare imitation to previous data on pantomimed and actual tool use. Of note, 156 patients (64.3 ± 14.6 years; 56 female) with first-ever left-hemispheric ischemic stroke were prospectively examined 4...
November 30, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27904754/polymethylmethacrylate-imbedded-with-antibiotics-cranioplasty-an-infection-solution-for-moderate-and-large-defects-reconstruction
#11
Paulo Valdeci Worm, Tobias Ludwig do Nascimento, Fabricio do Couto Nicola, Eduardo Farias Sanches, Carlos Fernando Dos Santos Moreira, Luiz Pedro Willimann Rogério, Marcelo Martins Dos Reis, Guilherme Finger, Marcus Vinicius Martins Collares
BACKGROUND: In cases where autologous bone graft reconstruction is not possible (such as comminuted fractures, bone graft reabsorption, or infection) and the use of synthetic material is required, polymethylmethacrylate (PMMA) use is a safe and efficient solution. Studies comparing the incidence of postoperative complications between autologous and synthetic cranioplasty are heterogeneous, not allowing a conclusion of which is the best material for skull defects reconstruction. Current medical literature lacks prospective well-delineated studies with long-term follow-up that analyze the impact of antibiotic use in PMMA cranial reconstruction of moderate and large defects...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27900415/-management-of-anesthesia-in-endovascular-interventions
#12
T Rössel, R Paul, T Richter, S Ludwig, T Hofmockel, A R Heller, T Koch
Cardiovascular diseases are one of the leading causes of morbidity and mortality in Germany. In these patients, the high-risk profile necessitates an interdisciplinary and multimodal approach to treatment. Endovascular interventions and vascular surgery have become established as an important element of this strategy in the past; however, the different anatomical localizations of pathological vascular alterations make it necessary to use a wide spectrum of procedural options and methods; therefore, the requirements for management of anesthesia are variable and necessitate a differentiated approach...
November 29, 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27898640/2016-note-to-reviewers
#13
Stephen Ludwig, Gary Fleisher, Fran Klass, Zella Ludwig
No abstract text is available yet for this article.
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27896930/you-are-not-alone
#14
EDITORIAL
M Ludwig, A Högner, A Patzak
Be assured, not alone at all, indifferent what you wish for. Between you and me and the bedpost, you are even outnumbered. Outnumbered by trillions of tiny individuals living, laughing and eating on and inside you. Actually, the numbers are a little scary: its 10:1 microorganisms versus humans, and in terms of genes, we are even talking about an incredible 100:1 ratio. So, dear advocates of individualism, we are literally more bug than human. And as our little cohabitants have followed us on our journey through evolution, we better continue to cooperate in order to stay healthy...
November 29, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27895807/cpas-based-sequencing-on-the-bgiseq-500-to-explore-small-non-coding-rnas
#15
Tobias Fehlmann, Stefanie Reinheimer, Chunyu Geng, Xiaoshan Su, Snezana Drmanac, Andrei Alexeev, Chunyan Zhang, Christina Backes, Nicole Ludwig, Martin Hart, Dan An, Zhenzhen Zhu, Chongjun Xu, Ao Chen, Ming Ni, Jian Liu, Yuxiang Li, Matthew Poulter, Yongping Li, Cord Stähler, Radoje Drmanac, Xun Xu, Eckart Meese, Andreas Keller
BACKGROUND: We present the first sequencing data using the combinatorial probe-anchor synthesis (cPAS)-based BGISEQ-500 sequencer. Applying cPAS, we investigated the repertoire of human small non-coding RNAs and compared it to other techniques. RESULTS: Starting with repeated measurements of different specimens including solid tissues (brain and heart) and blood, we generated a median of 30.1 million reads per sample. 24.1 million mapped to the human genome and 23...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27889344/malabsorption-of-a-bioresorbable-vascular-scaffold-system-leading-to-very-late-in-scaffold-restenosis-more-than-3-5-years-after-implantation-assessment-by-optical-coherence-tomography
#16
Michael Dommasch, Nikolas Langwieser, Karl-Ludwig Laugwitz, Tareq Ibrahim
No abstract text is available yet for this article.
November 17, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27886606/a-symmetric-supercapacitor-biofuel-cell-hybrid-device-based-on-enzyme-modified-nanoporous-gold-an-autonomous-pulse-generator
#17
Xinxin Xiao, Peter Ó Conghaile, Dónal Leech, Roland Ludwig, Edmond Magner
The integration of supercapacitors with enzymatic biofuel cells (BFCs) can be used to prepare hybrid devices in order to harvest significantly higher power output. In this study, a supercapacitor/biofuel cell hybrid device was prepared by the immobilisation of redox enzymes with electrodeposited poly(3,4-ethylenedioxythiophene) (PEDOT) and the redox polymer [Os(2,2'-bipyridine)2(polyvinylimidazole)10Cl](+/2+)(Os(bpy)2PVI) on dealloyed nanoporous gold. The thickness of the deposition layer can be easily controlled by tuning the deposition conditions...
November 9, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27886503/signatures-of-hyperfine-spin-orbit-and-decoherence-effects-in-a-pauli-spin-blockade
#18
T Fujita, P Stano, G Allison, K Morimoto, Y Sato, M Larsson, J-H Park, A Ludwig, A D Wieck, A Oiwa, S Tarucha
We detect in real time interdot tunneling events in a weakly coupled two-electron double quantum dot in GaAs. At finite magnetic fields, we observe two characteristic tunneling times T_{d} and T_{b}, belonging to, respectively, a direct and a blocked (spin-flip-assisted) tunneling. The latter corresponds to the lifting of a Pauli spin blockade, and the tunneling times ratio η=T_{b}/T_{d} characterizes the blockade efficiency. We find pronounced changes in the behavior of η upon increasing the magnetic field, with η increasing, saturating, and increasing again...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27886307/a-simple-guiding-principle-for-the-temperature-dependence-of-the-solubility-of-light-gases-in-imidazolium-based-ionic-liquids-derived-from-molecular-simulations
#19
Daniela Kerlé, Majid Namayandeh Jorabchi, Ralf Ludwig, Sebastian Wohlrab, Dietmar Paschek
We have determined the temperature dependence of the solvation behavior of a large collection of important light gases in imidazolium-based ionic liquids with the help of extensive molecular dynamics simulations. The motivation of our study is to unravel common features of the temperature dependent solvation under well controlled conditions, and to provide a guidance for cases, where experimental data from different sources disagree significantly. The solubility of molecular hydrogen, oxygen, nitrogen, methane, krypton, argon, neon and carbon dioxide in the imidazolium based ionic liquids of type 1-n-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Cnmim][NTf2]) with varying alkyl side chain lengths n = 2, 4, 6, 8 is computed for a temperature range between 300 K and 500 K at 1 bar...
November 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27884243/high-sensitivity-troponin-t-and-mortality-after-elective-percutaneous-coronary-intervention
#20
Gjin Ndrepepa, Roisin Colleran, Siegmund Braun, Salvatore Cassese, Julia Hieber, Massimiliano Fusaro, Sebastian Kufner, Ilka Ott, Robert A Byrne, Oliver Husser, Christian Hengstenberg, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
BACKGROUND: The prognostic value of high-sensitivity troponin T (hs-TnT) elevation after elective percutaneous coronary intervention (PCI) in patients with or without raised baseline hs-TnT levels is unclear. OBJECTIVES: The goal of this study was to assess whether the prognostic value of post-procedural hs-TnT level after elective PCI depends on the baseline hs-TnT level. METHODS: This study included 5,626 patients undergoing elective PCI who had baseline and peak post-procedural hs-TnT measurements available...
November 29, 2016: Journal of the American College of Cardiology
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