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https://www.readbyqxmd.com/read/28324008/vessel-network-architecture-of-adult-human-islets-promotes-distinct-cell-cell-interactions-in-situ-and-is-altered-after-transplantation
#1
Christian M Cohrs, Chunguang Chen, Stephan R Jahn, Julia Stertmann, Helena Chmelova, Jürgen Weitz, Andrea Bähr, Nikolai Klymiuk, Anja Steffen, Barbara Ludwig, Virginia Kamvissi, Eckhard Wolf, Stefan R Bornstein, Michele Solimena, Stephan Speier
Islet cell hormone release is modulated by signals from endothelial and endocrine cells within the islet. However, models of intra-islet vascularization and paracrine cell signaling are mostly based on rodent pancreas. We here assessed for the first time the architecture and endocrine cell interaction of the vascular network in unperturbed human islets in situ and their potential to re-establish their endogenous vascular network after transplantation in vivo. We prepared pancreas tissue slices of fresh tissue obtained from non-diabetic patients undergoing partial pancreatectomy...
January 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28315429/vinpocetine-reduces-diclofenac-induced-acute-kidney-injury-through-inhibition-of-oxidative-stress-apoptosis-cytokine-production-and-nf-%C3%AE%C2%BAb-activation-in-mice
#2
Victor Fattori, Sergio M Borghi, Carla F S Guazelli, Andressa C Giroldo, Jefferson Crespigio, Allan J C Bussmann, Letícia Coelho-Silva, Natasha G Ludwig, Tânia L Mazzuco, Rubia Casagrande, Waldiceu A Verri
Acute kidney injury (AKI) represents a complex clinical condition associated with significant morbidity and mortality. Approximately 19%-33% AKI episodes in hospitalized patients are related to drug-induced nephrotoxicity. Although considered safe, non-steroidal anti-inflammatory drugs such as diclofenac have received special attention in the past years due to the potential risk of renal damage. Vinpocetine is a nootropic drug known to have anti-inflammatory properties. In the present study, we investigated the effect and mechanisms of vinpocetine in a model of diclofenac-induced AKI...
March 14, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28306371/carfilzomib-and-dexamethasone-vs-bortezomib-and-dexamethasone-in-patients-with-relapsed-multiple-myeloma-results-of-the-phase-3-study-endeavor-nct01568866-according-to-age-subgroup
#3
Heinz Ludwig, Meletios A Dimopoulos, Philippe Moreau, Wee-Joo Chng, Hartmut Goldschmidt, Roman Hájek, Thierry Facon, Ludek Pour, Ruben Niesvizky, Albert Oriol, Laura Rosiñol, Aleksandr Suvorov, Gianluca Gaidano, Tomas Pika, Katja Weisel, Vesselina Goranova-Marinova, Antonio Palumbo, Heidi H Gillenwater, Nehal Mohamed, Sanjay Aggarwal, Shibao Feng, Douglas Joshua
No abstract text is available yet for this article.
March 17, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28304217/the-efficacy-of-teriflunomide-in-patients-who-received-prior-disease-modifying-treatments-subgroup-analyses-of-the-teriflunomide-phase-3-temso-and-tower-studies
#4
Mark S Freedman, Jerry S Wolinsky, Giancarlo Comi, Ludwig Kappos, Tomas P Olsson, Aaron E Miller, Karthinathan Thangavelu, Myriam Benamor, Philippe Truffinet, Paul W O'Connor
Teriflunomide is a once-daily oral immunomodulator approved for relapsing-remitting multiple sclerosis (MS). The objective of this post hoc analysis of the phase 3, pooled TEMSO (NCT00134563) and TOWER (NCT00751881) dataset is to evaluate the effect of teriflunomide treatment on annualised relapse rate and disability worsening across patient subgroups defined according to prior disease-modifying therapy exposure. This analysis provides further supportive evidence for a consistent effect of teriflunomide across a broad range of patients with relapsing MS, including patients who have used and discontinued other disease-modifying therapies...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28302395/social-cognition-psychometric-evaluation-scope-in-people-with-early-psychosis-a-preliminary-study
#5
Kelsey A Ludwig, Amy E Pinkham, Philip D Harvey, Skylar Kelsven, David L Penn
Social cognition is an important outcome in schizophrenia research. Unfortunately, there has been a lack of consensus regarding which measures of social cognition best capture this domain of functioning. The Social Cognition Psychometric Evaluation (SCOPE) study was developed to address the need for a battery of measures that have sound psychometric properties and can be implemented in clinical trials for individuals with chronic schizophrenia. The current study expands upon the SCOPE study by examining the psychometric properties of the eight candidate measures administered to individuals early in the course of psychosis...
March 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28296229/phytosterol-mediated-inhibition-of-intestinal-cholesterol-absorption-in-mice-is-independent-of-liver-x-receptor
#6
Lídia Cedó, David Santos, Iziar A Ludwig, Reija Silvennoinen, Annabel García-León, Leena Kaipiainen, José M Carbó, Annabel F Valledor, Helena Gylling, Maria-José Motilva, Petri T Kovanen, Miriam Lee-Rueckert, Francisco Blanco-Vaca, Joan Carles Escolà-Gil
SCOPE: Previous studies have proposed that phytosterols activate liver X receptors (LXR) in the intestine, thereby reducing intestinal cholesterol absorption and promoting fecal cholesterol excretion. METHODS AND RESULTS: In the present study, we examined the effects of dietary phytosterol supplementation on intestinal cholesterol absorption and fecal neutral sterol excretion in LXRαβ-deficient mice, and wild-type mice treated with synthetic high-affinity LXRαβ agonists...
March 15, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28294347/nadroparin-carries-a-potentially-high-risk-of-inducing-cutaneous-delayed-type-hypersensitivity-responses
#7
Marc Schindewolf, Andreas Recke, Detlef Zillikens, Edelgard Lindhoff-Last, Ralf J Ludwig
BACKGROUND: Heparins are widely used for the prophylaxis/treatment of thromboembolic events. As adverse effects, heparin-induced skin lesions occur frequently (in 7.5-39% of patients). Skin lesions may be the only clinical manifestation of life-threatening immune-mediated heparin-induced thrombocytopenia, but are commonly caused by a delayed-type hypersensitivity response [heparin-induced delayed-type hypersensitivity (HIHS)]. Risk factors have not been prospectively identified. OBJECTIVES: To identify possible risk factors for heparin-induced skin lesions from three independent clinical trials in a combined analysis...
March 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28293204/what-are-the-ingredients-for-an-inequity-paradigm-manipulating-the-experimenter-s-involvement-in-an-inequity-task-with-dogs
#8
Désirée Brucks, Sarah Marshall-Pescini, Jennifer L Essler, Jim McGetrick, Ludwig Huber, Friederike Range
Cooperation is only beneficial if the outcome is equally shared between individuals involved in the cooperative interaction. A mechanism to limit the development of unequal cooperation is inequity aversion, the negative reaction to unequal treatment. While inequity aversion has been studied extensively across many animal species, it remains unclear whether inequity aversion elicited in experimental settings is directed to the cooperative partner animal or rather to the experimenter distributing the rewards unequally...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28292941/preclinical-anti-tumor-efficacy-of-bay-1129980-a-novel-auristatin-based-anti-c4-4a-lypd3-antibody-drug-conjugate-for-the-treatment-of-non-small-cell-lung-cancer
#9
Jörg Willuda, Lars Linden, Hans-Georg Lerchen, Charlotte Kopitz, Beatrix Stelte-Ludwig, Carol Pena, Claudia Lange, Sven Golfier, Christoph Kneip, Patricia E Carrigan, Kirk Mclean, Joachim Schuhmacher, Oliver von Ahsen, Jörg Müller, Frank Dittmer, Rudolf Beier, Sherif El-Sheikh, Jan Tebbe, Gabriele Leder, Heiner Apeler, Rolf Jautelat, Karl Ziegelbauer, Bertolt Kreft
C4.4A (LYPD3) has been identified as a cancer- and metastasis-associated internalizing cell surface protein that is expressed in non-small cell lung cancer (NSCLC), with particularly high prevalence in the squamous cell carcinoma (SCC) subtype. With the exception of skin keratinocytes and esophageal endothelial cells, C4.4A expression is scarce in normal tissues, presenting an opportunity to selectively treat cancers with a C4.4A-directed antibody-drug conjugate (ADC). We have generated BAY 1129980 (C4.4A-ADC), an ADC consisting of a fully human C4...
March 14, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28292426/kibra-and-merlin-activate-the-hippo-pathway-spatially-distinct-from-and-independent-of-expanded
#10
Ting Su, Michael Z Ludwig, Jiajie Xu, Richard G Fehon
The Hippo pathway is emerging as a key evolutionarily conserved signaling mechanism that controls organ size. Three membrane-associated proteins, Kibra, Merlin, and Expanded, regulate pathway activity, but the precise molecular mechanism by which they function is still poorly understood. Here we provide evidence that Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex. Merlin and Kibra together recruit the adapter protein Salvador, which in turn recruits the core kinase Hippo...
March 13, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28290756/denosumab-and-surgery-for-the-treatment-of-perthes-disease-in-a-9-year-old-boy-favorable-course-documented-by-comprehensive-imaging-a-case-report
#11
A Ludwig Meiss, Florian Barvencik, Kornelia Babin, Gerald Eggers-Stroeder
No abstract text is available yet for this article.
March 14, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28287134/correlating-oxygen-evolution-catalysts-activity-and-electronic-structure-by-a-high-throughput-investigation-of-ni1-y-zfeycrzox
#12
Christoph Schwanke, Helge Sören Stein, Lifei Xi, Kirill Sliozberg, Wolfgang Schuhmann, Alfred Ludwig, Kathrin M Lange
High-throughput characterization by soft X-ray absorption spectroscopy (XAS) and electrochemical characterization is used to establish a correlation between electronic structure and catalytic activity of oxygen evolution reaction (OER) catalysts. As a model system a quasi-ternary materials library of Ni1-y-zFeyCrzOx was synthesized by combinatorial reactive magnetron sputtering, characterized by XAS, and an automated scanning droplet cell. The presence of Cr was found to increase the OER activity in the investigated compositional range...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28285840/secondary-malignancies-after-rectal-cancer-resection-with-and-without-radiation-therapy-a-propensity-adjusted-population-based-seer-analysis
#13
Rene Warschkow, Ulrich Güller, Thomas Cerny, Bruno Martin Schmied, Ludwig Plasswilm, Paul Martin Putora
BACKGROUND: The relationship between radiation therapy for rectal cancer and secondary malignancies is debated. The present study is the first population-based analysis using conventional multivariable analyses as well as propensity score matching to assess this relationship. METHODS: Overall, 77,484 patients after resection of localized or locally advanced rectal adenocarcinoma diagnosed between 1973 and 2012 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry...
March 9, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28281024/retinal-toxicity-after-cisplatin-based-chemotherapy-in-patients-with-germ-cell-cancer
#14
Simon Dulz, Niels H Asselborn, Klaus-Peter Dieckmann, Cord Matthies, Walter Wagner, Jens Weidmann, Christoph Seidel, Christoph Oing, Lars A Berger, Winfried Alsdorf, Blanche Mankichian, Christian Meyer, Malte W Vetterlein, Philipp Gild, Tim A Ludwig, Armin Soave, Philipp Schriefer, Andreas Becker, Sascha A Ahyai, Karin Oechsle, Carsten Bokemeyer, Lars Wagenfeld, Margit Fisch, Michael Hartmann, Felix K-H Chun, Luis A Kluth
PURPOSE: Visual impairment represents an infrequent form of cisplatin-induced neurotoxicity; however, visual deterioration has been reported in several studies. To evaluate potential morphological and functional retinal alterations in patients with germ cell cancer (GCC) treated with cisplatin-based chemotherapy (CBC). METHODS: Multi-disciplinary and multi-institutional study design. Examination of 28 eyes of 14 male GCC patients, who had received at least one cycle of CBC...
March 9, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28280847/neuronal-differentiation-capability-of-nasal-polyps-of-chronic-rhinosinusitis
#15
Michael Koennecke, Robert Böscke, Ann-Christin Pfannerstill, Stefan Reers, Martina Elsner, Benjamin Fell, Anja Richter, Karl-Ludwig Bruchhage, Sandra Schumann, Ralph Pries, Ludger Klimek, Barbara Wollenberg
Chronic rhinosinusitis with nasal polyps is considered a subgroup of chronic rhinosinusitis and a significant health problem, but the pathogenesis remains unclear to date. Therefore, we investigated the stemness to determine the role of stem cells in nasal polyps, with additional analysis of the neuronal differentiation potential of nasal polyp cells. We determined gene and protein expression profiles of stem cells in nasal polyp tissues, using whole genome microarray, quantitative real-time PCR (qPCR), immunohistochemistry, and flow cytometry...
March 9, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28279779/effects-of-mate-separation-in-female-and-social-isolation-in-male-free-living-greylag-geese-on-behavioural-and-physiological-measures
#16
Sonja C Ludwig, Katharina Kapetanopoulos, Kurt Kotrschal, Claudia A F Wascher
The presence of a social partner may significantly contribute to coping with stressful events, whereas dyadic separation generally increases glucocorticoid levels and, thereby, might also affect immune function and health. To study the covariation between social factors, immuno-reactive corticosterone metabolites, haematology and parasite product excretion patterns in a free-living, long-term monogamous bird, we separated pair mates in Greylag geese (Anser anser). We isolated the males of eight pairs for 48hours to examine behavioural, adrenocortical, haematological and parasitological responses to mate removal in the female partners, and to social isolation in the males...
March 6, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28279775/procollagen-lysine-2-oxoglutarate-5-dioxygenase-2-plod2-expression-in-brain-arteriovenous-malformations-bavm-and-its-association-with-bavm-size
#17
Belal Neyazi, Levent Tanrikulu, Ludwig Wilkens, Christian Hartmann, Klaus-Peter Stein, Claudia A Dumitru, I Erol Sandalcioglu
BACKGROUND: and Purpose: Brain arteriovenous malformations (bAVM) are severe conditions which can cause severe neurological deficits and mortality. The underlying cellular and molecular mechanisms associated with bAVM growth and rupture still remain unclear. The objective of this study was to explore the potential role of PLOD2 (Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) in the pathophysiology of bAVM. METHODS: Expression and localization of PLOD2 were analyzed on tissue microarrays from bAVM patients (n=60) by immunohistochemistry...
March 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28278597/a-digital-feedback-system-to-support-implementation-of-measurement-based-care-by-school-based-mental-health-clinicians
#18
Aaron R Lyon, Michael D Pullmann, Kelly Whitaker, Kristy Ludwig, Jessica Knaster Wasse, Elizabeth McCauley
Evidence supports the utility of measurement-based care (MBC) to improve youth mental health outcomes, but clinicians rarely engage in MBC practices. Digital measurement feedback systems (MFS) may reflect a feasible strategy to support MBC adoption and sustainment. This pilot study was initiated to evaluate the impact of a MFS and brief consultation supports to facilitate MBC uptake and sustainment among mental health clinicians in the education sector, the most common mental health service delivery setting for youth...
March 2, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28278068/an-improved-experimental-methodology-to-evaluate-the-effectiveness-of-protective-gloves-against-nanoparticles-in-suspension
#19
Ludwig Vinches, Mohamed Zemzem, Stéphane Hallé, Caroline Peyrot, Kevin J Wilkinson, Nathalie Tufenkji
Recent studies underline the potential health risks associated to the "nano" revolution, particularly for the workers who handle engineered nanoparticles (ENPs) that can be found in the formulation of several commercial products. Although many Health & Safety agencies recommend the use of protective gloves against chemicals, few studies have investigated the effectiveness of these gloves towards nanoparticle suspensions. Moreover, the data that are available are often contradictory. This study was designed to evaluate the effectiveness of protective gloves against nanoparticles in suspension...
February 21, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28276483/vascular-transcriptome-profiling-identifies-sphingosine-kinase-1-as-a-modulator-of-angiotensin-ii-induced-vascular-dysfunction
#20
Mateusz Siedlinski, Ryszard Nosalski, Piotr Szczepaniak, Agnieszka H Ludwig-Gałęzowska, Tomasz Mikołajczyk, Magdalena Filip, Grzegorz Osmenda, Grzegorz Wilk, Michał Nowak, Paweł Wołkow, Tomasz J Guzik
Vascular dysfunction is an important phenomenon in hypertension. We hypothesized that angiotensin II (AngII) affects transcriptome in the vasculature in a region-specific manner, which may help to identify genes related to vascular dysfunction in AngII-induced hypertension. Mesenteric artery and aortic transcriptome was profiled using Illumina WG-6v2.0 chip in control and AngII infused (490 ng/kg/min) hypertensive mice. Gene set enrichment and leading edge analyses identified Sphingosine kinase 1 (Sphk1) in the highest number of pathways affected by AngII...
March 9, 2017: Scientific Reports
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