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Magnesium AND supplement

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https://www.readbyqxmd.com/read/29912157/trpm6-is-essential-for-magnesium-uptake-and-epithelial-cell-function-in-the-colon
#1
Francesca Luongo, Giuseppe Pietropaolo, Mathieu Gautier, Isabelle Dhennin-Duthille, Halima Ouadid-Ahidouch, Federica I Wolf, Valentina Trapani
Intestinal magnesium (Mg) uptake is essential for systemic Mg homeostasis. Colon cells express the two highly homologous transient receptor potential melastatin type (TRPM) 6 and 7 Mg2+ channels, but their precise function and the consequences of their mutual interaction are not clear. To explore the functional role of TRPM6 and TRPM7 in the colon, we used human colon cell lines that innately express both channels and analyzed the functional consequences of genetic knocking-down, by RNA interference, or pharmacological inhibition, by NS8593, of either channel...
June 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29908683/determination-of-serum-bone-related-minerals-during-denosumab-treatment-in-osteoporosis-patients-with-rheumatoid-arthritis-mineral-change-by-denosumab-in-osteoporosis-with-rheumatoid-arthritis
#2
Takako Suzuki, Yukio Nakamura, Hiroyuki Kato
OBJECTIVES: This study included 51 osteoporosis patients with rheumatoid arthritis (RA) who were treated with anti-resorption drug, denosumab. To date, there has been no report on the changes of bone-related minerals after anti-resorption drug therapy. METHODS: Fifty one osteoporotic patients with RA were retrospectively enrolled. Serum Zinc (Zn), Magnesium (Mg), Iron (Fe), and Copper (Cu) were examined at 1 week, 1, 2, 4, 6, 8, 10, 12 months. Lumbar spine (L1-4) bone mineral density (L-BMD), and bilateral total hip BMD (H-BMD) were examined before and at 6 and 12 months after treatment commencement...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29900589/mineral-and-bone-disorders-in-conventional-hemodialysis-challenges-and-solutions
#3
Takayuki Hamano
Despite the advent of cinacalcet and noncalcium-containing phosphate binders, controlling the progression of vascular calcification (VC) is still challenging. Recent reports demonstrate that carbamylation driven by high urea concentration aggravates VC, suggesting the importance of adequate dialysis in retarding its progression. Theoretically, other promising measures include the use of iron-based phosphate binders, vitamin K, and magnesium supplements, which should be investigated in future randomized controlled trials (RCTs), ideally with hard outcomes...
June 13, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29899597/bioaccessibility-of-phenolic-compounds-lutein-and-bioelements-of-preparations-containing-chlorella-vulgaris-in-artificial-digestive-juices
#4
Bożena Muszyńska, Agata Krakowska, Jan Lazur, Barbara Jękot, Łukasz Zimmer, Agnieszka Szewczyk, Katarzyna Sułkowska-Ziaja, Ewa Poleszak, Włodzimierz Opoka
Chlorella vulgaris Beijerinck is a spherical, green alga belonging to the genus Chlorella and family Chlorellaceae. It has high nutritional value and shows multiple biological effects. Dietary supplements that contain extracts of C. vulgaris are sold in the form of tablets, capsules, powders, and aqueous solutions. To the best of our knowledge, this is the first study to determine the content of bioelements (zinc, iron, and magnesium), phenolic compounds, and lutein before and after incubation with artificial digestive juices from preparations containing C...
2018: Journal of Applied Phycology
https://www.readbyqxmd.com/read/29898113/mineral-supplementation-stimulates-the-immune-system-and-antioxidant-responses-of-dairy-cows-and-reduces-somatic-cell-counts-in-milk
#5
Amanda C Warken, Leandro S Lopes, Nathieli B Bottari, Patrícia Glombowsky, Gabriela M Galli, Vera M Morsch, Maria Rosa C Schetinger, Aleksandro S DA Silva
The aim of this study was to evaluate whether the use of subcutaneous mineral supplementation would affect metabolic parameters, immunological response, milk quality and composition of dairy cows in the postpartum period. Twelve pregnant primiparous Holstein cows, were divided into two groups: six animals supplemented with the mineral complex (magnesium, phosphorus, potassium, selenium and copper), and six animals used as controls. Milk samples were collected every two other weeks postpartum up to sixty days of lactation to analyze composition and quality...
April 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29897029/magnesium-and-mood-disorders-systematic-review-and-meta-analysis
#6
Danny Phelan, Patricio Molero, Miguel A Martínez-González, Marc Molendijk
BACKGROUND: Magnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+ intake and Mg2+ blood levels in the mood disorders and the effects of Mg2+ supplements on mood. METHOD: Systematic review and meta-analyses. RESULTS: Adherence to a Mg2+-rich diet was negatively associated with depression in cross-sectional (odds ratio = 0...
July 2018: BJPsych Open
https://www.readbyqxmd.com/read/29894321/association-between-advanced-keratoconus-and-serum-levels-of-zinc-calcium-magnesium-iron-copper-and-selenium
#7
Shahram Bamdad, Naser Owji, Alireza Bolkheir
PURPOSE: To investigate the possibility of an association between serum levels of zinc (Zn), calcium (Ca), magnesium (Mg), iron (Fe), copper (Cu), and selenium (Se) and advanced keratoconus (KCN). METHODS: In this study, 50 patients with advanced KCN and 50 control subjects were included. Plasma levels of Zn, Ca, Mg, Fe, Cu, and Se were compared between the groups. RESULTS: Mean ± SD age of the patients in the case and control groups was 29...
June 7, 2018: Cornea
https://www.readbyqxmd.com/read/29878034/calcium-absorption-may-be-affected-after-either-sleeve-gastrectomy-or-roux-en-y-gastric-bypass-in-premenopausal-women-a-2-y-prospective-study
#8
Fernando Carrasco, Karen Basfi-Fer, Pamela Rojas, Attila Csendes, Karin Papapietro, Juana Codoceo, Jorge Inostroza, Nancy F Krebs, Jamie L Westcott, Leland V Miller, Manuel Ruz
Background: Although Roux-en-Y gastric bypass (RYGBP) is known to reduce calcium absorption (CA), the effects of vertical sleeve gastrectomy (SG) and its long-term implications on CA have not yet been studied. Objective: The aim of this study was to evaluate changes in CA and its relation with modifications of bone mineral density (BMD), intakes of calcium and vitamin D, vitamin D status, and parathyroid hormone (PTH) concentrations ≤24 mo after SG and RYGBP, respectively...
June 6, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29867006/egg-consumption-in-infants-is-associated-with-longer-recumbent-length-and-greater-intake-of-several-nutrients-essential-in-growth-and-development
#9
Yanni Papanikolaou, Victor L Fulgoni
Nutrient intake during infancy is critical for healthy growth and development. The present study examined egg consumption and associations with nutrient intakes, markers of growth and weight-related measures in infants 6⁻24 months of age ( N = 561) compared to infant egg non-consumers ( N = 2129). Egg consumers were defined as those infants consuming eggs (i.e., with the exclusion of mixed dishes) during a 24-h dietary recall. Associations with nutrient intakes and markers of growth variables were evaluated using data from What We Eat in America, the dietary component of the National Health and Nutrition Examination Survey, 2001⁻2012...
June 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29793668/magnesium-as-a-calcification-inhibitor
#10
REVIEW
Lucie Hénaut, Ziad A Massy
Vascular calcification (VC) is associated with elevated cardiovascular mortality rates in patients with CKD. Recent clinical studies of patients with advanced CKD have observed an association between low serum magnesium (Mg) levels on one hand and elevated VC and cardiovascular mortality on the other. These findings have stimulated interest in understanding Mg's impact on CKD in general and the associated VC in particular. In vitro and preclinical in vivo data indicate that Mg has the potential to protect vascular smooth muscle cells against calcification via several different molecular mechanisms...
May 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29793665/oral-magnesium-supplementation-and-metabolic-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#11
REVIEW
Martha Rodríguez-Morán, Luis E Simental-Mendía, Claudia I Gamboa-Gómez, Fernando Guerrero-Romero
The objective of the study was to evaluate the efficacy of oral magnesium supplementation in the improvement of metabolic syndrome (MetS) and its components. This is a randomized double-blind, placebo-controlled clinical trial that enrolled 198 individuals with MetS and hypomagnesemia who were randomly allocated to receive either 30 mL of magnesium chloride 5% solution, equivalent to 382 mg of elemental magnesium (n = 100), or placebo solution (n = 98), daily for 16 weeks. Serum magnesium levels <1...
May 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29793664/magnesium-and-cardiovascular-disease
#12
REVIEW
Kamonwan Tangvoraphonkchai, Andrew Davenport
Magnesium is the most abundant intracellular divalent cation and essential for maintaining normal cellular physiology and metabolism, acting as a cofactor of numerous enzymes, regulating ion channels and energy generation. In the heart, magnesium plays a key role in modulating neuronal excitation, intracardiac conduction, and myocardial contraction by regulating a number of ion transporters, including potassium and calcium channels. Magnesium also has a role in regulating vascular tone, atherogenesis and thrombosis, vascular calcification, and proliferation and migration of endothelial and vascular smooth muscle cells...
May 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29793663/magnesium-and-blood-pressure-a-physiology-based-approach
#13
REVIEW
Joëlle C Schutten, Michel M Joosten, Martin H de Borst, Stephan J L Bakker
Hypertension is an important public health challenge because of its high prevalence and strong association with cardiovascular disease and premature death. Hypertension is a major cause of CKD, is present in more than 80% of CKD patients, and contributes to CKD progression. Risk factors for hypertension include, but are not limited to, age, race, family history, obesity, physical inactivity, tobacco use, and inadequate intake of minerals such as calcium, potassium, and magnesium. Magnesium is the second most abundant intracellular cation in the human body and plays an important role in insulin and adenosine triphosphate metabolism...
May 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29793661/dietary-magnesium-and-chronic-disease
#14
REVIEW
Forrest H Nielsen
Although official magnesium (Mg) dietary reference intakes are open to question, a significant number of adults likely have intakes that are in the range of 50%-99% of the requirement. This moderate or marginal (subclinical) deficient Mg intake generally is asymptomatic. Animal studies, however, indicate that moderate or subclinical Mg deficiency primes phagocytic cells for the release of proinflammatory cytokines leading to chronic inflammatory and oxidative stress. Human studies have found that dietary Mg is inversely related to serum or plasma C-reactive protein (CRP)...
May 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29788815/effect-of-magnesium-loading-dose-on-insulin-resistance-in-patients-with-stress-induced-hyperglycemia-a-randomized-clinical-trial
#15
Zinat Heidary, Hossein Khalili, Mostafa Mohammadi, Mohammad-Taghi Beigmohammadi, Alireza Abdollahi
OBJECTIVES: There is currently no evidence that whether magnesium supplementation would improve stress-induced hyperglycemia (SIH) in critically ill patients. In this study, effects of magnesium loading dose on insulin resistance (IR) indices were evaluated in critically ill patients without diabetes having SIH. METHODS: Seventy critically ill patients with SIH were assigned to receive a loading dose of magnesium (7.5 g of magnesium sulfate in 500 mL normal saline as intravenous infusion over an 8-hour period) or placebo...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29788266/dietary-magnesium-alleviates-experimental-murine-colitis-through-upregulation-of-the-transient-receptor-potential-melastatin-6-channel
#16
Valentina Trapani, Valentina Petito, Angelica Di Agostini, Daniela Arduini, Willem Hamersma, Giuseppe Pietropaolo, Francesca Luongo, Vincenzo Arena, Egidio Stigliano, Loris R Lopetuso, Antonio Gasbarrini, Federica I Wolf, Franco Scaldaferri
Background: Magnesium (Mg) is essential for human health and is absorbed mainly in the intestine. In view of the likely occurrence of an Mg deficit in inflammatory bowel disease (IBD) and the documented role of Mg in modulating inflammation, the present study addresses whether Mg availability can affect the onset and progression of intestinal inflammation. Methods: To study the correlation between Mg status and disease activity, we measured magnesemia by atomic absorption spectroscopy in a cohort of IBD patients...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29780355/therapeutic-interference-with-vascular-calcification-lessons-from-klotho-hypomorphic-mice-and-beyond
#17
REVIEW
Florian Lang, Christina Leibrock, Lisann Pelzl, Meinrad Gawaz, Burkert Pieske, Ioana Alesutan, Jakob Voelkl
Medial vascular calcification, a major pathophysiological process associated with cardiovascular disease and mortality, involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs). In chronic kidney disease (CKD), osteo-/chondrogenic transdifferentiation of VSMCs and, thus, vascular calcification is mainly driven by hyperphosphatemia, resulting from impaired elimination of phosphate by the diseased kidneys. Hyperphosphatemia with subsequent vascular calcification is a hallmark of klotho-hypomorphic mice, which are characterized by rapid development of multiple age-related disorders and early death...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29773176/effects-of-zinc-magnesium-and-chromium-supplementation-on-cardiometabolic-risk-in-adults-with-metabolic-syndrome-a-double-blind-placebo-controlled-randomised-trial
#18
Ha-Na Kim, Se-Hong Kim, Young-Mi Eun, Sang-Wook Song
The prevalence of metabolic syndrome (MetS) has been increasing rapidly worldwide. The activities of zinc, magnesium and chromium have a potential association with MetS; therefore, we investigated the effects of zinc, magnesium and chromium supplements on metabolic risk factors in adults with MetS. In this double-blind, placebo controlled randomised study, 32 adults with MetS were included in the zinc, magnesium, and chromium-administered group (n = 16) or the placebo group (n = 16) and received either 300 mg magnesium, 600 μg chromium and 36 mg zinc per day or placebo over a 24-week period...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29769070/serum-magnesium-levels-and-risk-of-coronary-artery-disease-mendelian-randomisation-study
#19
Susanna C Larsson, Stephen Burgess, Karl Michaëlsson
BACKGROUND: Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary artery disease (CAD). METHODS: This Mendelian randomisation analysis is based on summary-level data from the CARDIoGRAMplusC4D consortium's 1000 Genomes-based genome-wide association meta-analysis of 48 studies with a total of 60,801 CAD cases and 123,504 non-cases...
May 17, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29765771/reduction-in-nephrotoxicities-using-short-hydration-for-chemotherapy-containing-cisplatin-a-consecutive-analysis-of-467-patients-with-thoracic-malignancies
#20
Midori Tanaka, Hidehito Horinouchi, Yasushi Goto, Shintaro Kanda, Yutaka Fujiwara, Hiroshi Nokihara, Noboru Yamamoto, Yuichiro Ohe
Background: Conventional hydration (CH) in chemotherapy containing cisplatin (CDDP) has been recommended to prevent renal toxicity. Although an increasing number of studies have demonstrated the feasibility of short hydration (SH), few large studies have reported the superiority of SH, compared with CH, in terms of nephrotoxicities. Methods: We conducted a consecutive retrospective analysis of 467 patients who had been treated with chemotherapy including CDDP. Statistical analyses were performed to evaluate the risk factors for nephrotoxicities...
2018: ESMO Open
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