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https://www.readbyqxmd.com/read/29321305/arabidopsis-rna-polymerase-v-mediates-enhanced-compaction-and-silencing-of-geminivirus-and-transposon-chromatin-during-host-recovery-from-infection
#1
Tami Coursey, Elizabeth Regedanz, David M Bisaro
Plants employ RNA-directed DNA methylation (RdDM) and dimethylation of histone 3 lysine 9 (H3K9me2) to silence geminiviruses and transposable elements (TEs). We previously showed that canonical RdDM (Pol IV-RdDM) involving RNA polymerases IV and V (Pol IV and Pol V) is required for Arabidopsis thaliana to recover from infection with Beet curly top virus lacking a suppressor protein that inhibits methylation (BCTV L2-). Recovery, which is characterized by reduced viral DNA levels and symptom remission, allows normal floral development...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29313396/the-role-of-tamis-transanal-minimally-invasive-surgery-in-the-management-of-advanced-rectal-cancer-one-shared-story-of-three-exceptional-cases
#2
Dimitrios Giannoulopoulos, Constantinos Nastos, Maria Gavriatopoulou, Antonios Vezakis, Dionysios Dellaportas, Ira Sotirova, Georgios Giokas, Georgios Polymeneas, Theodosios Theodosopoulos
PURPOSE OF THE STUDY: The current gold standard for contemporary treatment of rectal cancer is total mesorectal excision (TME), achieving excellent local disease control and low recurrence rates. However, TME may be associated with postoperative mortality and quality of life deterioration. Therefore, the need to develop less radical treatment strategies has emerged. Transanal minimally invasive surgery (TAMIS) is currently indicated only for early rectal cancer. However, local excision following chemoradiation has yielded promising clinical outcomes in selected cases with more advanced disease...
January 9, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29308967/effects-of-kinesio-taping-on-breast-cancer-related-lymphedema-a-meta-analysis-in-clinical-trials
#3
Karina Tamy Kasawara, Jéssica Monique Rossetti Mapa, Vilma Ferreira, Marco Aurélio Nemitalla Added, Silvia Regina Shiwa, Nelson Carvas, Patricia Andrade Batista
BACKGROUND: Lymphedema is known as a secondary complication of breast cancer treatment, caused by reduction on lymphatic flow and lymph accumulation on interstitial space. The Kinesio Taping (KT) has become an alternative treatment for lymphedema volume reduction. The objective of the study was to evaluate the literature through a systematic review on KT effects on lymphedema related to breast cancer. METHODS: Search strategies were performed by the following keywords: "Kinesio Taping," "Athletic Tape," "Cancer," "Neoplasm," "Lymphedema," and "Mastectomy" with derivations and different combinations...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29307733/safety-and-feasibility-of-intravesical-instillation-of-botulinum-toxin-a-in-hydrogel-based-slow-release-delivery-system-in-interstitial-cystitis-bladder-pain-syndrome-patients-a-pilot-study
#4
Yishai H Rappaport, Amnon Zisman, Michal Jeshurun-Gutshtat, Tami Gerassi, Gil Hakim, Yuri Vinshtok, Kobi Stav
OBJECTIVE: To assess feasibility and safety of a mixture instillation of TC-3 Gel, a novel reverse-thermal gelation hydrogel, and botulinum toxin-A (BTX-A) for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). TC-3 Gel/BTX-A mix is instilled into the bladder as liquid, solidifies due to body heat and gradually dissolves to release BTX-A for several hours. METHODS: A single intravesical instillation of 200U BTX-A premixed with 40ml TC-3 Gel was delivered to the bladder...
January 4, 2018: Urology
https://www.readbyqxmd.com/read/29304877/what-is-required-for-community-based-participatory-research-to-be-effective-studying-asylum-seekers-access-to-healthcare
#5
Ifat Vainer, Tamy Shohat
This commentary on the paper by Gottlieb et al. [IJPHR November 2017] expands the discussion of the community-based participatory research approach, which is based on equal partnership between researchers and community members. We emphasize the essential principles that were originally introduced in order for this approach to be effective.
January 5, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29298362/helmets-matter-kentucky-motorcycle-crash-victims-seen-at-a-tennessee-trauma-center
#6
George M Testerman, Daniel C Prior, Tamie D Wells, William C Sumner, Jeffrey T Johnston, Sarah E Rollins, Jeremy M Meyer
OBJECTIVES: Motorcycle helmet laws vary by state, with Kentucky requiring helmets only for younger riders. We hypothesized that motorcyclists injured in Kentucky and seen at a Tennessee trauma center would be more likely to be unhelmeted, have more severe head injuries, and sustain more fatal injuries than those injured in Tennessee or Virginia. METHODS: A Trauma Registry review of 729 injured motorcyclists from January 2005 through June 2015 examined state location of crash, demographics, helmet use, and clinical outcomes...
January 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29296020/linking-soil-biology-and-chemistry-in-biological-soil-crust-using-isolate-exometabolomics
#7
Tami L Swenson, Ulas Karaoz, Joel M Swenson, Benjamin P Bowen, Trent R Northen
Metagenomic sequencing provides a window into microbial community structure and metabolic potential; however, linking these data to exogenous metabolites that microorganisms process and produce (the exometabolome) remains challenging. Previously, we observed strong exometabolite niche partitioning among bacterial isolates from biological soil crust (biocrust). Here we examine native biocrust to determine if these patterns are reproduced in the environment. Overall, most soil metabolites display the expected relationship (positive or negative correlation) with four dominant bacteria following a wetting event and across biocrust developmental stages...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29295472/a-prospective-birth-cohort-study-on-maternal-cholesterol-levels-and-offspring-attention-deficit-hyperactivity-disorder-new-insight-on-sex-differences
#8
Yuelong Ji, Anne W Riley, Li-Ching Lee, Heather Volk, Xiumei Hong, Guoying Wang, Rayris Angomas, Tom Stivers, Anastacia Wahl, Hongkai Ji, Tami R Bartell, Irina Burd, David Paige, Margaret D Fallin, Barry Zuckerman, Xiaobin Wang
Growing evidence suggests that maternal cholesterol levels are important in the offspring's brain growth and development. Previous studies on cholesterols and brain functions were mostly in adults. We sought to examine the prospective association between maternal cholesterol levels and the risk of attention deficit hyperactivity disorder (ADHD) in the offspring. We analyzed data from the Boston Birth Cohort, enrolled at birth and followed from birth up to age 15 years. The final analyses included 1479 mother-infant pairs: 303 children with ADHD, and 1176 neurotypical children without clinician-diagnosed neurodevelopmental disorders...
December 23, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29294951/criminal-protection-orders-for-women-victims-of-domestic-violence-explicating-predictors-of-level-of-restrictions-among-orders-issued
#9
Tami P Sullivan, Nicole H Weiss, Carolina Price, Nicole E Pugh
Criminal protection orders (POs), with varying degrees of restrictions, are issued by the criminal justice system to enhance the safety of victims of domestic violence (DV). Limited research exists to elucidate factors associated with their issuance. Therefore, the purpose of this study was to investigate how demographic, relationship, parenting, and court-process-related factors are related to the level of restriction the PO places on the offender. Two-hundred ninety-eight women who were victims in a criminal DV case ( M age 36...
October 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294901/social-reactions-to-ipv-disclosure-and-ptsd-symptom-severity-assessing-avoidant-coping-as-a-mediator
#10
Jennifer N Schackner, Nicole H Weiss, Katie M Edwards, Tami P Sullivan
Women's experiences of negative social reactions to disclosure of intimate partner violence (IPV) victimization have been linked to greater posttraumatic stress disorder (PTSD) symptom severity. However, research has not identified factors that may explain this association. The goal of the current study was to extend research in this area by elucidating the potential mediating role of avoidant coping in the relations among negative and positive social reactions to IPV disclosure and PTSD symptom severity. Participants were 173 community women currently experiencing IPV who disclosed their victimization to another individual ( M age = 36...
August 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29289852/trauma-exposure-and-heavy-drinking-and-drug-use-among-college-students-identifying-the-roles-of-negative-and-positive-affect-lability-in-a-daily-diary-study
#11
Nicole H Weiss, Krysten W Bold, Ateka A Contractor, Tami P Sullivan, Stephen Armeli, Howard Tennen
Trauma exposure is linked to heavy drinking and drug use among college students. Extant research reveals positive associations between negative affect lability and both trauma exposure and alcohol use. This study aimed to extend past research by using daily diary methods to test whether (a) individuals with (versus without) trauma exposure experience greater negative and positive affect lability, (b) negative and positive affect lability are associated with heavy drinking and drug use, and (c) negative and positive affect lability mediate the relations between trauma exposure and heavy drinking and drug use...
December 13, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29284406/an-additive-effect-of-leading-role-in-the-organization-between-social-participation-and-dementia-onset-among-japanese-older-adults-the-ages-cohort-study
#12
Yuta Nemoto, Tami Saito, Satoru Kanamori, Taishi Tsuji, Kokoro Shirai, Hiroyuki Kikuchi, Kazushi Maruo, Takashi Arao, Katsunori Kondo
BACKGROUND: Several previous studies reported social participation may reduce the incident of dementia; therefore, the type of positions held in the organization may relate to dementia onset. However, this hypothesis remains largely unknown. The purpose of the present study was to examine the additive effect of a leadership position in the organization on dementia onset and social participation among elderly people in a local community, according to data from a Japanese older adults cohort study...
December 29, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29274630/molecular-tools-for-pathway-engineering-in-saccharomyces-cerevisiae
#13
REVIEW
Pamela B Besada-Lombana, Tami L McTaggart, Nancy A Da Silva
Molecular tools for the regulation of protein expression in Saccharomyces cerevisiae have contributed to rapid advances in pathway engineering for this yeast. This review considers new and enhanced additions to this toolbox, focusing on experimental approaches to modulate enzyme synthesis and enzyme fate. Methods for genome engineering, regulation of transcription, post-translational protein localization, and combinatorial screening and sensing in S. cerevisiae are highlighted, and promising new approaches are introduced...
December 20, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29273889/tumor-necrosis-factor-receptor-associated-factor-6-is-required-to-inhibit-foreign-body-giant-cell-formation-and-activate-osteoclasts-under-inflammatory-and-infectious-conditions
#14
Akihito Oya, Eri Katsuyama, Mayu Morita, Yuiko Sato, Tami Kobayashi, Kana Miyamoto, Toru Nishiwaki, Atsushi Funayama, Yoshinari Fujita, Takashi Kobayashi, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto
Osteoclasts and foreign body giant cells (FBGCs) are derived from common progenitors and share properties such as multi-nucleation capacity induced by cell-cell fusion; however, mechanisms underlying lineage determination between these cells remain unclear. Here we show that, under inflammatory conditions, osteoclasts are stimulated in a manner similar to M1 macrophages, while formation of FBGCs, which exhibit M2-like phenotypes, is inhibited in a manner similar to that seen in M1/M2 macrophage polarization...
December 22, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29273435/severe-abnormal-behavior-incidence-after-administration-of-neuraminidase-inhibitors-using-the-national-database-of-medical-claims
#15
Yuuki Nakamura, Tamie Sugawara, Yasushi Ohkusa, Kiyosu Taniguchi, Chiaki Miyazaki, Mariko Momoi, Nobuhiko Okabe
An earlier study using the number of abnormal behaviors reported to the study group as the numerator and the number of influenza patient prescribed each neuraminidase inhibitor (NI) estimated by respective pharmaceutical companies found no significant difference among incidence rates of the most severe abnormal behaviors by type of NI throughout Japan. However, the dataset for the denominator used in that earlier study was the estimated number of prescriptions. In the present study, to compare the incidence rates of abnormal behavior more precisely among influenza patients administered several sorts of NI or administered no NI, we used data obtained from the National Database of Electronic Medical Claims (NDBEMC) as the denominator to reach a definitive conclusion...
December 19, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29250835/em-algorithm-estimation-of-a-structural-equation-model-for-the-longitudinal-study-of-the-quality-of-life
#16
Antoine Barbieri, Myriam Tami, Xavier Bry, David Azria, Sophie Gourgou, Caroline Bascoul-Mollevi, Christian Lavergne
Health-related quality of life (HRQoL) data are measured via patient questionnaires, completed by the patients themselves at different time points. We focused on oncology data gathered through the use of European Organization for Research and Treatment of Cancer questionnaires, which decompose HRQoL into several functional dimensions, several symptomatic dimensions, and the global health status (GHS). We aimed to perform a global analysis of HRQoL and reduce the number of analyses required by using a two-step approach...
December 18, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29232720/inhibitors-in-hemophilia-treatment-challenges-and-novel-options
#17
Assaf Arie Barg, Tami Livnat, Gili Kenet
No abstract text is available yet for this article.
December 12, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29228060/model-of-hindlimb-unloading-in-adult-female-rats-characterizing-bone-physicochemical-microstructural-and-biomechanical-properties
#18
Melise Jacon Peres-Ueno, Camila Tami Stringhetta-Garcia, Robson Chacon Castoldi, Guilherme Akio Tamura Ozaki, Antônio Hernandes Chaves-Neto, Rita Cássia Menegati Dornelles, Mário Jefferson Quirino Louzada
Prolonged bedrest and microgravity induce alterations to bone, leading to bone fragility and compromising the quality of life. In this study, we characterized the physicochemical changes, microstructure, and biomechanics of the femurs of female adult rats in response to hindlimb unloading for 21 days. Twenty 6-month-old Wistar female rats were distributed into control (CON) and hindlimb unloading (HLU) groups. Analysis the in vivo bone mineral density (BMD) by dual energy x-ray absorptiometry (DXA) from the femurs was performed at the beginning and end of the experiment; plasma levels of calcium, phosphorus, and alkaline phosphatase, tartrate-resistant acid phosphatase activity, assessed by spectrophotometry, and estradiol, measured by enzyme-linked immunosorbent assay, was performed after the experiment...
2017: PloS One
https://www.readbyqxmd.com/read/29222024/continuous-and-not-continuous-2-week-treadmill-training-enhances-the-performance-in-the-passive-avoidance-test-in-ischemic-gerbils
#19
Ana Paula Cassiano Silveira, Takae Tamy Kitabatake, Vivian Mozol Pantaleo, Hélio Zangrossi, Guilherme Bertolino, Elaine Caldeira de Oliveira Guirro, Hugo Celso Dutra de Souza, João Eduardo de Araujo
This study aims to investigate the frequency and total duration effects of the 2-week treadmill training after experimental ischemic stroke in the passive avoidance test. We performed bilateral occlusion of common external carotid arteries, for five minutes, in Mongolian gerbils. The training groups were: continuous training for twelve consecutive days or not continuous training for six non-consecutive days. The groups remained in the treadmill for 15min, with the speed set at 10m/min, and the training started 24h after the stroke...
December 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29220633/developing-adaptive-treatment-strategies-to-address-suicidal-risk-in-college-students-a-pilot-sequential-multiple-assignment-randomized-trial-smart
#20
Jacqueline Pistorello, David Jobes, Scott Compton, Nadia Samad Locey, Joseph C Walloch, Robert Gallop, Josephine S Au, Samantha K Noose, Maria Young, Jacquelyn Johnson, Yani Dickens, Patricia Chatham, Tami Jeffcoat, Georgia Dalto, Spondita Goswami
OBJECTIVES: This pilot study investigated the potential to utilize adaptive treatment strategies for treating moderate to severe suicidal risk among college students. This paper will describe the unique design and report on feasibility and acceptability findings. METHODS: A two-stage Sequential Multiple Assignment Randomized Trial (SMART) was conducted: In Stage 1, 62 suicidal college students were randomized to either a suicide-focused or a treatment-as-usual condition (4-8 weeks)...
December 8, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
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