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https://www.readbyqxmd.com/read/28440749/correction-pcgf6-prc1-suppresses-premature-differentiation-of-mouse-embryonic-stem-cells-by-regulating-germ-cell-related-genes
#1
Mitsuhiro Endoh, Takaho A Endo, Jun Shinga, Katsuhiko Hayashi, Anca Farcas, Kit-Wan Ma, Shinsuke Ito, Jafar Sharif, Tamie Endoh, Naoko Onaga, Manabu Nakayama, Tomoyuki Ishikura, Osamu Masui, Benedikt M Kessler, Toshio Suda, Osamu Ohara, Akihiko Okuda, Robert J Klose, Haruhiko Koseki
No abstract text is available yet for this article.
April 25, 2017: ELife
https://www.readbyqxmd.com/read/28419385/development-and-feasibility-of-a-group-based-therapeutic-yoga-program-for-women-with-chronic-pelvic-pain
#2
Alison J Huang, Tami S Rowen, Priscilla Abercrombie, Leslee L Subak, Michael Schembri, Traci Plaut, Maria T Chao
Objective.:  To develop a group-based therapeutic yoga program for women with chronic pelvic pain (CPP) and explore the effects of this program on pain severity, sexual function, and well-being. Methods.:  A yoga therapy program for CPP was developed by a multidisciplinary panel of clinicians, researchers, and yoga consultants. Women reporting moderate to severe pelvic pain for at least six months were recruited into a single-arm trial. Participants attended twice weekly group classes focusing on Iyengar-based yoga techniques and were instructed to practice yoga at home an hour a week for six weeks...
April 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28416221/ombitasvir-paritaprevir-and-ritonavir-plus-dasabuvir-for-8-weeks-in-previously-untreated-patients-with-hepatitis-c-virus-genotype-1b-infection-without-cirrhosis-garnet-a-single-arm-open-label-phase-3b-trial
#3
Tania M Welzel, Tarik Asselah, Emily O Dumas, Stefan Zeuzem, David Shaw, Rawi Hazzan, Xavier Forns, Tami Pilot-Matias, Wenjing Lu, Daniel E Cohen, Jordan J Feld
BACKGROUND: Clinical studies have shown high rates of sustained virological response (hepatitis C virus [HCV] RNA <15 IU/mL) at post-treatment week 12 (SVR12) in patients with genotype 1b infection with and without cirrhosis who received coformulated ombitasvir, paritaprevir, and ritonavir, plus dasabuvir, without ribavirin, for 12 weeks. In this study, we aimed to assess 8-week treatment with ombitasvir, paritaprevir, and ritonavir, plus dasabuvir, without ribavirin in patients infected with HCV genotype 1b without cirrhosis...
April 13, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28415629/a-h1n1-pdm09-influenza-infection-vaccine-inefficiency
#4
Nehemya Friedman, Yaron Drori, Rakefet Pando, Aharona Glatman-Freedman, Hanna Sefty, Ravit Bassal, Yaniv Stein, Tamy Shohat, Ella Mendelson, Musa Hindiyeh, Michal Mandelboim
The last influenza pandemic, caused by the swine A(H1N1)pdm09 influenza virus, began in North America at 2009. Since then, the World Health Organization (WHO) recommended integration of the swine-based virus A/California/07/2009 strain in yearly vaccinations. Yet, infections with A(H1N1)pdm09 have continued in subsequent years. The reasons for this are currently unknown. During the 2015-2016 influenza season, we noted an increased prevalence of A(H1N1)pdm09 influenza virus infection in Israel. Our phylogenetic analysis indicated that the circulating A(H1N1)pdm09 strains belonged to 6B...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28406621/discovery-of-selective-phosphodiesterase-1-inhibitors-with-memory-enhancing-properties
#5
Brian Dyck, Bryan Branstetter, Tawfik Gharbaoui, Andrew R Hudson, J Guy Breitenbucher, Laurent Gomez, Iriny Botrous, Tami Marrone, Richard Barido, Charles K Allerston, E Peder Cedervall, Rui Xu, Vandana Sridhar, Ryan Barker, Kathleen Aertgeerts, Kara Schmelzer, David Neul, Dong Lee, Mark Eben Massari, Carsten B Andersen, Kristen Sebring, Xianbo Zhou, Robert Petroski, James Limberis, Martin Augustin, Lawrence E Chun, Thomas E Edwards, Marco Peters, Ali Tabatabaei
A series of potent thienotriazolopyrimidinone-based PDE1 inhibitors was discovered. X-ray crystal structures of example compounds from this series in complex with the catalytic domain of PDE1B and PDE10A were determined, allowing optimization of PDE1B potency and PDE selectivity. Reduction of hERG affinity led to greater than a 3000-fold selectivity for PDE1B over hERG. 6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one was identified as an orally bioavailable and brain penetrating PDE1B enzyme inhibitor with potent memory-enhancing effects in a rat model of object recognition memory...
April 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28404108/ombitasvir-paritaprevir-and-ritonavir-plus-ribavirin-in-adults-with-hepatitis-c-virus-genotype-4-infection-and-cirrhosis-agate-i-a-multicentre-phase-3-randomised-open-label-trial
#6
Tarik Asselah, Christophe Hézode, Roula B Qaqish, Magdy ElKhashab, Tarek Hassanein, George Papatheodoridis, Jordan J Feld, Christophe Moreno, Stefan Zeuzem, Peter Ferenci, Yao Yu, Rebecca Redman, Tami Pilot-Matias, Niloufar Mobashery
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clinical trial data for treatment remain limited. We assessed the combination of two direct-acting antivirals, ombitasvir (NS5A inhibitor) and paritaprevir (NS3/4A protease inhibitor; co-dosed with ritonavir) plus ribavirin in patients with HCV genotype 4 infection and compensated cirrhosis...
September 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28402194/words-can-hurt-the-effects-of-physical-and-psychological-partner-violence-on-condom-negotiation-and-condom-use-among-young-women
#7
Courtney Peasant, Tami P Sullivan, Tiarney D Ritchwood, Gilbert R Parra, Nicole H Weiss, Jaimie P Meyer, James G Murphy
Physical and psychological intimate partner violence (IPV) are prevalent on college campuses and may affect young women's condom use behavior. This study explored condom negotiation as a mediator of the relation of physical and psychological IPV to condom use among college women. A total of 235 heterosexual college women were recruited during September 2012-May 2013. Participants completed online questionnaires assessing lifetime history of IPV, frequency of condom negotiation, and use of condoms during the last 30 days...
April 12, 2017: Women & Health
https://www.readbyqxmd.com/read/28387378/elevation-of-pro-inflammatory-cytokine-levels-following-anti-resorptive-drug-treatment-is-required-for-osteonecrosis-development-in-infectious-osteomyelitis
#8
Mayu Morita, Ryotaro Iwasaki, Yuiko Sato, Tami Kobayashi, Ryuichi Watanabe, Takatsugu Oike, Satoshi Nakamura, Yosuke Keneko, Kana Miyamoto, Kazuyuki Ishihara, Yoichiro Iwakura, Ken Ishii, Morio Matsumoto, Masaya Nakamura, Hiromasa Kawana, Taneaki Nakagawa, Takeshi Miyamoto
Various conditions, including bacterial infection, can promote osteonecrosis. For example, following invasive dental therapy with anti-bone resorptive agents, some patients develop osteonecrosis in the jaw; however, pathological mechanisms underlying these outcomes remain unknown. Here, we show that administration of anti-resorptive agents such as the bisphosphonate alendronate accelerates osteonecrosis promoted by infectious osteomyelitis. Potent suppression of bone turnover by these types of agents is considered critical for osteonecrosis development; however, using mouse models we found that acceleration of bone turnover by teriparatide injection did not prevent osteonecrosis but rather converted osteoclast progenitors to macrophages expressing inflammatory cytokines, which were required for osteonecrosis development...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28379997/wild-versus-domestic-prey-in-the-diet-of-reintroduced-tigers-panthera-tigris-in-the-livestock-dominated-multiple-use-forests-of-panna-tiger-reserve-india
#9
S S Kolipaka, W L M Tamis, M van 't Zelfde, G A Persoon, H H de Iongh
Grazing livestock in openly accessible areas is a common practice in the multiple-use forests of India; however, its compatibility with the reintroduction of tigers to these areas requires examination. Here, we investigated the diet of tigers in a livestock-dominated multiple-use buffer zone of the Panna Tiger Reserve, India. We hypothesised that the presence of feral cattle, along with open-access grazing practices in multiple-use forests, would increase the incidence of predation on livestock by tigers, even when wild prey are available...
2017: PloS One
https://www.readbyqxmd.com/read/28371078/efficacy-of-an-emollient-containing-diethylene-glycol-dilinoleic-acid-copolymer-for-the-treatment-of-dry-skin-and-pruritus-in-patients-with-senile-xerosis
#10
Runa Izumi, Osamu Negi, Tamie Suzuki, Mitsutoshi Tominaga, Atsuko Kamo, Yasushi Suga, Shoko Matsukuma, Kenji Takamori
BACKGROUND AND AIMS: Pruritus frequently reduces quality of life (QOL) in patients with senile xerosis. This study investigated the moisturizing and antipruritic effects of a topical emollient containing a diethylene glycol/dilinoleic acid copolymer (D/DC) in patients with pruritic senile xerosis. METHODS: This single-blind study involved 50 subjects, aged 50-75 years. Patients were randomized to self-applied treatment of the lower legs with 10% (n = 20) or 20% (n = 20) D/DC-containing cream, white petrolatum (n = 5), or no treatment (n = 5) thrice daily for four weeks...
March 30, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28370291/postregistration-monitoring-of-pesticides-is-urgently-required-to-protect-ecosystems
#11
REVIEW
Martina G Vijver, Ellard R Hunting, Tom A P Nederstigt, Wil L M Tamis, Paul J van den Brink, Peter M van Bodegom
Current admission policies for pesticides follow a controlled experimental tiered risk assessment approach, giving results that are difficult to extrapolate to a real-world situation. Later analyses of compounds such as DDT and neonicotinoid pesticides clearly show that the actual chemical impacts frequently affect many more components of an ecosystem than a priori suggested by risk assessment. Therefore, to manage the actual risks for ecosystems imposed by manufactured compounds, it is proposed that current admission policies for chemicals be enriched by using postregistration monitoring...
April 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28366881/substance-p-mediated-chemokine-production-promotes-monocyte-migration
#12
Sergei Spitsin, John Meshki, Angela Winters, Florin Tuluc, Tami D Benton, Steven D Douglas
The neuropeptide SP has physiologic and pathophysiologic roles in CNS and peripheral tissues and is involved in crosstalk between nervous and immune systems in various conditions, including HIV and SIV infection. Increased SP levels were demonstrated in plasma of HIV(+) individuals as well as in the CNS of SIV-infected, nonhuman primates. SP increases HIV infection in macrophages through interaction with its receptor, NK1R. The SP effect on immune system is both pro- and anti-inflammatory and includes up-regulation of a number of cytokines and cell receptors...
April 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28365523/thrombin-generation-as-a-predictor-of-thromboembolic-events-in-multiple-myeloma-patients
#13
Merav Leiba, Sarah Malkiel, Ivan Budnik, Gabriela Rozic, Abraham Avigdor, Adrian Duek, Arnon Nagler, Gili Kenet, Tami Livnat
BACKGROUND: Multiple myeloma (MM) is characterized by an increased incidence of thromboembolic events, especially when immunomodulatory drugs are used. Currently, our ability to predict these thrombotic events is limited. We hypothesized that global coagulation tests may be predictive of thrombotic events in MM patients. METHODS: Blood samples were taken from 36 MM patients before and during routine treatment. Thrombin generation (TG) tests including endogenous thrombin potential (ETP) and peak height were analyzed...
March 25, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28355962/indications-and-outcomes-from-32-consecutive-patients-for-the-treatment-of-rectal-lesions-by-transanal-minimally-invasive-surgery
#14
Luis J García-Flórez, Jorge L Otero-Díez, Ana I Encinas-Muñiz, Luis Sánchez-Domínguez
BACKGROUND: The aim of this study was to evaluate the feasibility, safety, perioperative morbidity, and short-term outcomes of the transanal minimally invasive surgery (TAMIS) technique. METHODS: This is a descriptive review of prospectively collected data from 32 consecutive patients who underwent TAMIS procedures in our colorectal unit over a 40-month period. GelPOINT Path port was used in all cases. Demographic data, indications, tumor characteristics, morbidity, and follow-up data were collected...
March 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28350479/treating-sexual-side-effects-from-oral-contraceptive-pills
#15
Tami Serene Rowen
No abstract text is available yet for this article.
March 28, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28349965/the-nicotinic-acetylcholine-receptor-%C3%AE-7-subunit-is-an-essential-negative-regulator-of-bone-mass
#16
Kazuaki Mito, Yuiko Sato, Tami Kobayashi, Kana Miyamoto, Eriko Nitta, Atsushi Iwama, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto
The nicotinic receptor α7nAchR reportedly regulates vagal nerve targets in brain and cardiac tissue. Here we show that nAchR7(-/-) mice exhibit increased bone mass due to decreased osteoclast formation, accompanied by elevated osteoprotegerin/RANKL ratios in serum. Vagotomy in wild-type mice also significantly increased the serum osteoprotegerin/RANKL ratio, and elevated bone mass seen in nAchR7(-/-) mice was reversed in α7nAchR/osteoprotegerin-doubly-deficient mice. α7nAchR loss significantly increased TNFα expression in Mac1-positive macrophages, and TNFα increased the osteoprotegerin/RANKL ratio in osteoblasts...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28348376/a-missense-single-nucleotide-polymorphism-in-the-aldh2-gene-rs671-is-associated-with-hip-fracture
#17
Kenichiro Takeshima, Yuji Nishiwaki, Yasunori Suda, Yasuo Niki, Yuiko Sato, Tami Kobayashi, Kana Miyamoto, Hisaya Uchida, Wataru Inokuchi, Takashi Tsuji, Atsushi Funayama, Masaya Nakamura, Morio Matsumoto, Yoshiaki Toyama, Takeshi Miyamoto
Hip fracture is the most severe bone fragility fracture among osteoporotic injuries. Family history is a known risk factor for fracture and now included among criteria for osteoporosis diagnosis and treatment; however, genetic factors underlying family history favoring fracture remain to be elucidated. Here we demonstrate that a missense SNP in the ALDH2 gene, rs671 (ALDH2*2), is significantly associated with hip fracture (odds ratio = 2.48, 95% confidence interval: 1.20-5.10, p = 0.021). The rs671 SNP was also significantly associated with osteoporosis development (odds ratio = 2...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28342132/endoscopic-mucosal-resection-versus-esophagectomy-for-intramucosal-adenocarcinoma-in-the-setting-of-barrett-s-esophagus
#18
Chao Li, Denise Tami Yamashita, Jeffrey David Hawel, Drew Bethune, Harry Henteleff, James Ellsmere
BACKGROUND: Esophagectomy has been the standard of care for patients with intramucosal adenocarcinoma (IMC) in the setting of Barrett's esophagus. It is, however, associated with significant post-operative morbidity and mortality. Endoscopic mucosal resection (EMR) offers a minimally invasive approach with lesser morbidity. This study investigates the transition from esophagectomy to EMR for IMC with respect to eradication rates, post-operative morbidity, and long-term survival. METHODS: Patients diagnosed with IMC from 2005 to 2013 were identified retrospectively...
March 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28338468/endoscopic-mucosal-resection-for-high-grade-dysplasia-and-intramucosal-carcinoma-a-canadian-experience
#19
Denise Tami Yamashita, Chao Li, Drew Bethune, Harry Henteleff, James Ellsmere
BACKGROUND: Endoscopic mucosal resection (EMR) is increasingly being used as a first-line treatment for Barrett esophagus (BE) with high-grade dysplasia (HGD) and intramucosal adenocarcinoma (IMC). We reviewed our experience with endoscopic treatment of BE with HGD and IMC at our institution with respect to eradication rates, complications and long-term recurrence. METHODS: We performed a single-centre retrospective review of all patients referred between October 2010 and August 2014 for EMR with dysplastic BE or IMC...
April 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28338404/effect-of-histone-deacetylase-inhibitor-butyroyloxymethyl-diethyl-phosphate-an-7-on-corneal-neovascularization-in-a-mouse-model
#20
Michal Schaap-Fogler, Irit Bahar, Ada Rephaeli, Mor Dahbash, Abraham Nudelman, Eitan Livny, Tilda Barliya, Yael Nisgav, Tami Livnat
PURPOSE: To examine whether butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, inhibits chemically induced corneal neovascularization (NV) in mice. METHODS: Corneal NV was induced in the right eye of male C57BL mice by application of a mixture of 75% silver nitrate and 25% potassium nitrate to the corneal center. Immediately thereafter, the mice were randomized into 2 groups, receiving an intraperitoneal injection of AN-7 or saline, which served as control...
March 24, 2017: Journal of Ocular Pharmacology and Therapeutics
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