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https://www.readbyqxmd.com/read/28798354/enpp1-is-an-anti-aging-factor-that-regulates-klotho-under-phosphate-overload-conditions
#1
Ryuichi Watanabe, Nobuyuki Fujita, Yuiko Sato, Tami Kobayashi, Mayu Morita, Takatsugu Oike, Kana Miyamoto, Makoto Kuro-O, Toshimi Michigami, Seiji Fukumoto, Takashi Tsuji, Yoshiaki Toyama, Masaya Nakamura, Morio Matsumoto, Takeshi Miyamoto
Control of phosphate metabolism is crucial to regulate aging in mammals. Klotho is a well-known anti-aging factor that regulates phosphate metabolism: mice mutant or deficient in Klotho exhibit phenotypes resembling human aging. Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) is required for Klotho expression under phosphate overload conditions. Loss-of-function Enpp1 (ttw/ttw) mice under phosphate overload conditions exhibited phenotypes resembling human aging and Klotho mutants, such as short life span, arteriosclerosis and osteoporosis, with elevated serum 1,25(OH)2D3 levels...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796598/prevalence-correlates-and-time-trends-of-multiple-chronic-conditions-among-israeli-adults-estimates-from-the-israeli-national-health-interview-survey-2014-2015
#2
Samah Hayek, Anneke Ifrah, Teena Enav, Tamy Shohat
INTRODUCTION: Chronic diseases constitute a major public health challenge. The prevalence of multiple chronic conditions (MCC) has increased. The objective of our study was to describe the prevalence, correlates, and time trends of MCC in the Israeli population and among the nation's 2 main population groups (Jewish and Arab). METHODS: To describe the prevalence of correlates of MCC, we used data from the 2014-2015 Israeli National Health Interview Survey-III (INHIS-III)...
August 10, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28794478/a-method-based-on-artificial-intelligence-to-fully-automatize-the-evaluation-of-bovine-blastocyst-images
#3
José Celso Rocha, Felipe José Passalia, Felipe Delestro Matos, Maria Beatriz Takahashi, Diego de Souza Ciniciato, Marc Peter Maserati, Mayra Fernanda Alves, Tamie Guibu de Almeida, Bruna Lopes Cardoso, Andrea Cristina Basso, Marcelo Fábio Gouveia Nogueira
Morphological analysis is the standard method of assessing embryo quality; however, its inherent subjectivity tends to generate discrepancies among evaluators. Using genetic algorithms and artificial neural networks (ANNs), we developed a new method for embryo analysis that is more robust and reliable than standard methods. Bovine blastocysts produced in vitro were classified as grade 1 (excellent or good), 2 (fair), or 3 (poor) by three experienced embryologists according to the International Embryo Technology Society (IETS) standard...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794060/assessment-of-health-related-quality-of-life-and-psychological-well-being-of-children-and-adolescents-with-obesity-enrolled-in-a-new-zealand-community-based-intervention-programme-an-observational-study
#4
Yvonne C Anderson, Lisa E Wynter, Katharine F Treves, Cameron C Grant, Joanna M Stewart, Tami L Cave, Trecia A Wouldes, José G B Derraik, Wayne S Cutfield, Paul L Hofman
OBJECTIVE: To describe health-related quality of life (HRQOL) and psychological well-being of children and adolescents at enrolment in a multidisciplinary community-based obesity programme and to determine association with ethnicity. This programme targeted indigenous people and those from most deprived households. Further, this cohort was compared with other populations/normative data. METHODS: This study examines baseline demographic data of an unblinded randomised controlled clinical trial...
August 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28791563/differences-in-quality-of-life-between-jewish-and-arab-patients-on-hemodialysis
#5
Orly Romano-Zelekha, Eliezer Golan, Anneke Ifrah, Talia Weinstein, Tamy Shohat
PURPOSE: Higher health-related quality of life (HRQOL) in dialysis patients has been associated with fewer hospitalizations and lower mortality. Since Arab patients on dialysis have better survival rates than Jewish patients, we hypothesized that they would have higher HRQOL. We also studied the impact of several risk factors on HRQOL in each population. METHODS: Based on a national dialysis registry, patients from 64 hemodialysis units were recruited to participate...
August 8, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28783776/odorous-volatile-organic-compounds-escherichia-coli-and-nutrient-concentrations-when-kiln-dried-pine-chips-and-corn-stover-bedding-are-used-in-beef-bedded-manure-packs
#6
Mindy J Spiehs, Elaine D Berry, James E Wells, David B Parker, Tami M Brown-Brandl
Pine ( spp.) bedding has been shown to lower the concentration of odorous volatile organic compounds (VOCs) and pathogenic bacteria compared with corn ( L.) stover bedding, but availability and cost limit the use of pine bedding in cattle confinement facilities. The objectives of this study were to determine if the addition of pine wood chips to laboratory-scaled bedded packs containing corn stover (i) reduced odorous VOC emissions; (ii) reduced total ; and (iii) changed the nutrient composition of the resulting manure-bedded packs...
July 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28782305/sensory-over-responsiveness-among-healthy-subjects-is-associated-with-a-pro-nociceptive-state
#7
Irit Weissman-Fogel, Yelena Granovsky, Tami Bar-Shalita
OBJECTIVE: Chronic pain patients show hypersensitivity to sensory non-painful stimuli. Sensory over-responsiveness (SOR) to innocuous daily stimuli, experienced as painful, is prevalent in 10% of the healthy population. This altered sensory processing may be an expression of over facilitation, or a less efficient pain inhibitory process in the pain pathways. We therefore aimed at investigating specifically the pain inhibitory system of subjects with SOR who are otherwise healthy, not studied as of yet...
August 7, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28770628/effects-of-a-knee-brace-with-a-patellar-hole-versus-without-a-patellar-hole-in-patients-with-knee-osteoarthritis-a-double-blind-randomized-controlled-trial
#8
Marco Aurélio Nemitalla Added, Caroline Added, Karina Tamy Kasawara, Viviane Perez Rotta, Diego Galace de Freitas
The objective of this study was to observe the immediate effect of a knee brace with a patellar hole versus without a patellar hole on pain perception in patients with knee osteoarthritis. To accomplish this, a double-blind, randomized controlled trial enrolled 108 patients divided into two groups (knee brace with a patellar hole or without a patellar hole). Patients were evaluated by the Visual Analogue Scale (VAS) in order to measure their pain sensation, the Timed Up and Go (TUG) test was used to evaluate their ability to walk, and the 8-m walking test (8MWT) was used to estimate their walking speed...
January 1, 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/28753431/project-drive-a-compendium-of-cancer-dependencies-and-synthetic-lethal-relationships-uncovered-by-large-scale-deep-rnai-screening
#9
E Robert McDonald, Antoine de Weck, Michael R Schlabach, Eric Billy, Konstantinos J Mavrakis, Gregory R Hoffman, Dhiren Belur, Deborah Castelletti, Elizabeth Frias, Kalyani Gampa, Javad Golji, Iris Kao, Li Li, Philippe Megel, Thomas A Perkins, Nadire Ramadan, David A Ruddy, Serena J Silver, Sosathya Sovath, Mark Stump, Odile Weber, Roland Widmer, Jianjun Yu, Kristine Yu, Yingzi Yue, Dorothee Abramowski, Elizabeth Ackley, Rosemary Barrett, Joel Berger, Julie L Bernard, Rebecca Billig, Saskia M Brachmann, Frank Buxton, Roger Caothien, Justina X Caushi, Franklin S Chung, Marta Cortés-Cros, Rosalie S deBeaumont, Clara Delaunay, Aurore Desplat, William Duong, Donald A Dwoske, Richard S Eldridge, Ali Farsidjani, Fei Feng, JiaJia Feng, Daisy Flemming, William Forrester, Giorgio G Galli, Zhenhai Gao, François Gauter, Veronica Gibaja, Kristy Haas, Marc Hattenberger, Tami Hood, Kristen E Hurov, Zainab Jagani, Mathias Jenal, Jennifer A Johnson, Michael D Jones, Avnish Kapoor, Joshua Korn, Jilin Liu, Qiumei Liu, Shumei Liu, Yue Liu, Alice T Loo, Kaitlin J Macchi, Typhaine Martin, Gregory McAllister, Amandine Meyer, Sandra Mollé, Raymond A Pagliarini, Tanushree Phadke, Brian Repko, Tanja Schouwey, Frances Shanahan, Qiong Shen, Christelle Stamm, Christine Stephan, Volker M Stucke, Ralph Tiedt, Malini Varadarajan, Kavitha Venkatesan, Alberto C Vitari, Marco Wallroth, Jan Weiler, Jing Zhang, Craig Mickanin, Vic E Myer, Jeffery A Porter, Albert Lai, Hans Bitter, Emma Lees, Nicholas Keen, Audrey Kauffmann, Frank Stegmeier, Francesco Hofmann, Tobias Schmelzle, William R Sellers
Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping of cancer dependencies has lagged behind and the discovery of therapeutic targets for counteracting tumor suppressor gene loss is needed. To identify vulnerabilities relevant to specific cancer subtypes, we conducted a large-scale RNAi screen in which viability effects of mRNA knockdown were assessed for 7,837 genes using an average of 20 shRNAs per gene in 398 cancer cell lines...
July 27, 2017: Cell
https://www.readbyqxmd.com/read/28747407/chronic-hindbrain-administration-of-oxytocin-is-sufficient-to-elicit-weight-loss-in-diet-induced-obese-rats
#10
Zachary S Roberts, Tami H Wolden-Hanson, Miles E Matsen, Vitaly Ryu, Cheryl H Vaughan, James L Graham, Peter J Havel, Daniel Wahieb Chukri, Michael W Schwartz, Gregory J Morton, James E Blevins
Oxytocin (OT) administration elicits weight loss in diet-induced obese (DIO) rodents, nonhuman primates and humans by both reducing energy intake and increasing energy expenditure (EE). Although the neurocircuitry underlying these effects remains uncertain, OT neurons in the paraventricular nucleus are positioned to control both energy intake and sympathetic nervous system outflow to interscapular brown adipose tissue (IBAT) through projections to both the hindbrain nucleus of the solitary tract and spinal cord...
July 26, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28744060/effects-of-physiotherapy-treatment-for-urinary-incontinence-in-patient-with-multiple-sclerosis
#11
Carla Maria de Abreu Pereira, Mariane Castiglione, Karina Tamy Kasawara
[Purpose] The aim of the study was to evaluate the benefits of physical therapy for urinary incontinence in patients with multiple sclerosis and to verify the impact of urinary incontinence on the patient's quality of life. [Subject and Methods] A case study of a 55-year-old female patient diagnosed with multiple sclerosis and mixed urinary incontinence was conducted. Physical therapy sessions were conducted once a week, in total 15 sessions, making use of targeted functional electrical vaginal stimulation, along with active exercises for the pelvic floor muscles and electrical stimulation of the posterior tibial nerve, behavioral rehabilitation and exercise at home...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28739429/llex-paraguariensis-decreases-oxidative-stress-in-bone-and-mitigates-the-damage-in-rats-during-perimenopause
#12
Camila Scacco Pereira, Camila Tami Stringhetta-Garcia, Lilian da Silva Xavier, Keny Gonçalves Tirapeli, Ariana Aparecida Ferreira Pereira, GiselIi Mitsuy Kayahara, José Marcelo Tramarim, Marcelo Macedo Crivelini, Karina Stringhetta Padovani, Andréia Machado Leopoldino, Mário Jefferson Quirino Louzada, Adriane Belló-Klein, Susana Francisca Llesuy, Edilson Ervolino, Rita Cássia Menegati Dornelles, Antonio Hernandes Chaves-Neto, Ana Cláudia de Melo Stevanato Nakamune
During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause...
July 21, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28728144/retinal-penetration-of-intravitreally-injected-tissue-plasminogen-activator-a-rat-model-study
#13
Kfir Tal, Assaf Dotan, Yael Nisgav, Mor Dachbash, Orly Gal-Or, Rita Ehrlich, Dan D Gaton, Dov Weinberger, Tami Livnat
PURPOSE: To determine whether intravitreal unconjugated tissue plasminogen activator (tPA) (alteplase) can penetrate the intact neural retina and reach the subretinal space in an experimental model. METHODS: This study was performed in 24 Sprague-Dawley rats aged 12 weeks. Under general anesthesia, the right eye was injected with either 0.75 μg of 3 μL tPA (14 rats; study group) or saline (10 rats, control group) into the vitreous. Animals were euthanized at 3, 24, and 48 h...
July 20, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28724337/handedness-effects-of-imagined-fine-motor-movements
#14
Christopher M Donoff, Christopher R Madan, Anthony Singhal
Previous studies of movement imagery have found inter-individual differences in the ability to imagine whole-body movements. The majority of these studies have used subjective scales to measure imagery ability, which may be confounded by other factors related to effort. Madan and Singhal [2013. Introducing TAMI: An objective test of ability in movement imagery. Journal of Motor Behavior, 45(2), 153-166. doi: 10.1080/00222895.2013.763764 ] developed the Test of Ability in Movement Imagery (TAMI) to address these confounds by using a multiple-choice format with objectively correct responses...
July 19, 2017: Laterality
https://www.readbyqxmd.com/read/28700563/the-relationship-between-serum-levels-of-prolactin-and-growth-hormone-in-the-early-postnatal-period
#15
Jonathan Daliot, Tami Laron-Kenet, Mohammad Wattad, Anat Ben-Dor, Pearl Lilos, Zvi Laron
BACKGROUND: In the neonatal period, pituitary hormones including prolactin (PRL) and growth hormone (hGH) are secreted in high amounts due to immature feedback mechanisms. As both hormones are secreted in part by the same somatomammotrophic cells, we investigated their relationship in newborns in relation to sex, gestational week, method of delivery and anthropometric data. METHODS: Serum levels of PRL and hGH were measured in blood from 225 newborns. Newborn data were extracted from medical records...
July 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28697062/morbidity-and-health-risk-factors-among-new-mexico-miners-a-comparison-across-mining-sectors
#16
Alice M Shumate, Kristin Yeoman, Tristan Victoroff, Kandace Evans, Roger Karr, Tami Sanchez, Akshay Sood, Anthony Scott Laney
OBJECTIVE: This study examines differences in chronic health outcomes between coal, uranium, metal, and nonmetal miners. METHODS: In a cross-sectional study using data from a health screening program for current and former New Mexico miners, log-binomial logistic regression models were used to estimate relative risks of respiratory and heart disease, cancer, osteoarthritis, and back pain associated with mining in each sector as compared with coal, adjusting for other relevant risk factors...
August 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28697045/patient-characteristics-menopause-symptoms-and-care-provided-at-an-interdisciplinary-menopause-clinic-retrospective-chart-review
#17
Beate C Sydora, Nese Yuksel, Nicole L Veltri, Justin Marillier, Christoph P Sydora, Maryna Yaskina, Lori Battochio, Tami M L Shandro, Sue Ross
OBJECTIVE: The goal of this study was to describe the characteristics, menopause symptoms, and treatment progressions in women cared for at an interdisciplinary menopause clinic. METHODS: We conducted a retrospective review of patient charts from women attending a multidisciplinary menopause clinic. Data collected from the charts included patient demographics, menopause symptoms, other concurrent medical conditions, and treatment recommendations. Data were entered into Research Electronic Data Capture database and analyzed descriptively...
July 10, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28690773/recent-advances-in-the-management-of-rectal-cancer-no-surgery-minimal-surgery-or-minimally-invasive-surgery
#18
REVIEW
Joseph M Plummer, Pierre-Anthony Leake, Matthew R Albert
Over the last decade, with the acceptance of the need for improvements in the outcome of patients affected with rectal cancer, there has been a significant increase in the literature regarding treatment options available to patients affected by this disease. That treatment related decisions should be made at a high volume multidisciplinary tumor board, after pre-operative rectal magnetic resonance imaging and the importance of total mesorectal excision (TME) are accepted standard of care. More controversial is the emerging role for watchful waiting rather than radical surgery in complete pathologic responders, which may be appropriate in 20% of patients...
June 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28689155/combination-of-hemostatic-therapies-for-treatment-of-patients-with-hemophilia-a-and-inhibitors
#19
Tami Livnat, Ivan Budnik, Sarina Levy-Mendelovich, Einat Avishai, Mudi Misgav, Assaf Arie Barg, Aharon Lubetsky, Tami Brutman-Barazani, Gili Kenet
BACKGROUND: Therapy application and monitoring of patients with hemophilia A (HA) and inhibitors are challenging. In the current study, combined FVIII - bypass therapy was implemented for a cohort of severe HA patients with inhibitors. METHODS: Plasma of 15 HA patients with inhibitors was spiked ex vivo with FVIII, rFVIIa, FEIBA and their combinations and thrombin generation (TG) was studied. Some patients who experienced hemarthroses or required minor surgeries were treated by a combined concomitant administration of FVIII+FEIBA as IV bolus doses...
June 27, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28685239/a-biodesign-approach-to-obtain-high-yields-of-biosimilars-by-anti-apoptotic-cell-engineering-a-case-study-to-increase-the-production-yield-of-anti-tnf-alpha-producing-recombinant-cho-cells
#20
Sultan Gulce Iz, Muge Anil Inevi, Pelin Saglam Metiner, Duygu Ayyildiz Tamis, Nazli Kisbet
Recent developments in medical biotechnology have facilitated to enhance the production of monoclonal antibodies (mAbs) and recombinant proteins in mammalian cells. Human mAbs for clinical applications have focused on three areas, particularly cancer, immunological disorders, and infectious diseases. Tumor necrosis factor alpha (TNF-α), which has both proinflammatory and immunoregulatory functions, is an important target in biopharmaceutical industry. In this study, a humanized anti-TNF-α mAb producing stable CHO cell line which produces a biosimilar of Humira (adalimumab) was used...
July 6, 2017: Applied Biochemistry and Biotechnology
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