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A Zambrowicz, A Zabłocka, Ł Bobak, J Macała, M Janusz, A Polanowski, T Trziszka
A large number of bioactive peptides isolated from natural sources are known to play important physiological roles in the human body. It is possible to use these as alternative therapy agents. One example is yolkin which can be useful as a food supplement, a natural therapeutic agent for preventing and treating cognitive disorders of various origins, preferably in patients with unsatisfactory responses to known therapies. A new simple method of isolation of yolkin based on precipitation with ethanol or acetone was developed...
September 1, 2017: Food Chemistry
Marta Lemieszewska, Marta Jakubik-Witkowska, Bartłomiej Stańczykiewicz, Aleksandra Zambrowicz, Agnieszka Zabłocka, Antoni Polanowski, Tadeusz Trziszka, Joanna Rymaszewska
No abstract text is available yet for this article.
February 2017: Archivum Immunologiae et Therapiae Experimentalis
Marta Lemieszewska, Marta Jakubik-Witkowska, Bartłomiej Stańczykiewicz, Aleksandra Zambrowicz, Agnieszka Zabłocka, Antoni Polanowski, Tadeusz Trziszka, Joanna Rymaszewska
The study aimed to assess the effect of the polypeptide Y complex (Yolkin), isolated from chicken egg yolk, on behavioural and cognitive functions. It also aimed to compare this activity with colostrum-derived substances (Colostrinin, Coloco), which have a confirmed impact on learning and memory. In the study, the effect of Yolkin, administered to rats of different ages, who performed various tasks involving spatial and episodic memory, motor functions and exploratory behavior, was assessed. The experiment was carried out in rats which were 6 and 12 months old...
October 2016: Archivum Immunologiae et Therapiae Experimentalis
Agnieszka Zabłocka, Agnieszka Sosnowska, Anna Urbaniak, Maria Janusz, Antoni Polanowski
In the hen immune system the egg content plays as significant a role in the development of the chick as colostrum does in newborn mammals. One of the most important proteins in this system seems to be the main yolk immunoglobulin IgY. It has been shown that IgY is accompanied by an immunostimulatory polypeptide complex named yolkin. In this report the biological activities of yolkin separated by means of four different procedures are presented. It was shown that yolkin acts as an inducer rather than a modulator of cytokine and nitric oxide release, and does not participate in the protection of cells against destructive effects of reactive oxygen species...
April 2014: Food & Function
Antoni Polanowski, Agnieszka Sosnowska, Agnieszka Zabłocka, Maria Janusz, Tadeusz Trziszka
The protein mixture of cytokine-inducing activity accompanying chicken immunoglobulin Y, named yolkin, consists of several peptides of molecular weight (MW) ranging from over 1 to 35 kDa. Yolkin and its constituent peptides were found to be efficient inducers of interleukin (IL)-1β, IL-6 and IL-10 secretion. N-terminal amino acid sequences of eight of the electrophoretically purified yolkin constituents revealed that all of them are homological to some fragments of the C-terminal domain of vitellogenin II...
July 2013: Biological Chemistry
A Polanowski, A Zabłocka, A Sosnowska, M Janusz, T Trziszka
Immunity transfer from a mother to the newborn does not depend exclusively on immunoglobulins. Peptides, which are characterized by immunoregulatory properties that accompany IgG(2), known as proline-rich polypeptide complex (PRP), have been discovered for the first time in ovine colostrum. In this report we present new data showing that some immunoregulatory peptides associated with the main immunoglobulin class, IgY, are also present in the avian immune system. Cytokine-inducing activity of particular fractions obtained from ovine colostrum, IgG+ (IgG(2) containing PRP), IgG- (IgG(2) free of PRP), and purified PRP, was compared with that of crude egg yolk IgY (IgY+), additionally purified egg yolk IgY (IgY-), and polypeptides accompanying IgY named Yolkin (Y), using an ex vivo model of whole human blood cells...
December 2012: Poultry Science
N I Sinitsyn, V I Petrosyan, V A Yolkin, N D Devyatkov, Gulyaev YuV, O V Betskii
New findings of an investigation of the interaction between electromagnetic waves in the millimeter range and water and biological media are reported.
2000: Critical Reviews in Biomedical Engineering
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