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curcumin, stroke

Serdar Altinay, Murat Cabalar, Cihan Isler, Funda Yildirim, Duygu Sultan Celik, Oguzhan Zengi, Abdurrahim Tas, Ahmet Gulcubuk
AIM: To investigate the neuroprotective effect of chronic curcumin supplementation on the rat forebrain prior to ischemia and reperfusion Material and Methods: Forebrain ischemia was induced by bilateral common carotid artery occlusion for 1 hour, followed by reperfusion for 72 hours. Older rats were divided into five groups: I, 300 mg/kg oral curcumin for 21 days before ischemia and 300 mg/kg intraperitoneal curcumin after ischemia; II, 300 mg/kg intraperitoneal curcumin after ischemia; III, 300 mg/kg oral curcumin for 21 days before ischemia; IV, only ischemia; V:, sham-operated...
April 13, 2016: Turkish Neurosurgery
Shuang Liu, Yungang Cao, Man Qu, Zheng Zhang, Liang Feng, Zusen Ye, Meijuan Xiao, Sheng T Hou, Rongyuan Zheng, Zhao Han
OBJECTIVES: To investigate whether curcumin regulates Notch signaling to cause neuroprotection and neurogenesis after focal ischemia reperfusion injury. METHOD: Focal ischemia reperfusion injury was modeled in rats by occluding the middle cerebral artery. These animals were given either curcumin (300 mg/kg) or corn oil (vehicle) by intraperitoneal injection starting 1 h after stroke and continuing for 7 d. In parallel, sham-operated control animals received vehicle...
June 2016: Neurological Research
Heni Rachmawati, Irene Surya Soraya, Neng Fisheri Kurniati, Annisa Rahma
Atherosclerosis and hypertension can potentially progess into dangerous cardiovascular diseases such as myocardial infarction and stroke. Statins are widely used to lower cholesterol levels while antihypertensive agents such as captopril are widely prescribed to treat high blood pressure. Curcumin, a phenolic compound isolated from Curcuma domestica, has been proven effective for a broad spectrum of diseases, including hypertension and hypercholesterolemia. Therefore, curcumin is quite promising as an alternative therapeutic compound...
2016: Scientia Pharmaceutica
Xiao-Dong Zhuang, Li-Zhen Liao, Xiao-Bian Dong, Xun Hu, Yue Guo, Zhi-Min Du, Xin-Xue Liao, Li-Chun Wang
This study describes the synthesis of a novel series of curcumin-inspired compounds via a facile synthetic route. The structures of these derivatives were ascertained using various spectroscopic and analytic techniques. The pharmacological effects of the target analogs were assessed by assaying their inhibition of angiotensin-converting enzyme (ACE). All of the synthesized derivatives exhibited considerable inhibition of ACE, with half-maximal inhibitory concentrations ranging from 1.23 to 120.32 μM. In a docking analysis with testicular ACE (tACE), the most promising inhibitor (4j) was efficiently accommodated in the deep cleft of the protein cavity, making close interatomic contacts with Glu162, His353, and Ala356, comparable with lisinopril...
2016: Drug Design, Development and Therapy
Yanping Miao, Sheng Zhao, Yang Gao, Ruijun Wang, Qiong Wu, Hui Wu, Tianyou Luo
The effects of curcumin (CCM) on cerebral ischemia/reperfusion injury are not well understood. The aim of this study was to investigate whether CCM attenuates inflammation and mitochondrial dysfunction in a rat model of cerebral ischemia/reperfusion injury and whether Sirt1 is involved in these potential protective effects. Sirtinol, a Sirt1 inhibitor, was used to elucidate the underlying mechanism. Rats were subjected to 2h of transient middle cerebral artery occlusion (MCAO), followed by reperfusion for 24h...
March 2016: Brain Research Bulletin
Niyaz Ahmad, Iqbal Ahmad, Sadiq Umar, Zeenat Iqbal, Mohd Samim, Farhan Jalees Ahmad
Abstract Stroke is a one of the leading causes of disease and deaths worldwide, which causes irreversible deterioration of the central nervous system. Curcuminoids are reported to have a potential role in the amelioration of cerebral ischemia but they exhibit low serum and tissue levels due to low solubility and poor absorption. Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC)-loaded PNIPAM nanoparticles (NPs) were prepared by free radical polymerization and characterized for particles size, entrapment efficiency, zeta potential, in vitro release and ex vivo permeation study...
September 19, 2014: Drug Delivery
Nilanjan Ghosh, Rituparna Ghosh, Zulfiqar A Bhat, Vivekananda Mandal, Sitesh C Bachar, Namsa D Nima, Otimenyin O Sunday, Subhash C Mandal
Ischemic brain injury is one of the leading causes of death worldwide and has attracted a lot of attention in the field of drug discovery. Cerebral ischemia is a complex pathological process involving a series of mechanisms, including generation of free radicals, oxidative stress, disruption of the membrane function, release of neurotransmitters and apoptosis. Thrombolytic therapy is the most effective therapeutic strategy, but the benefits are far from being absolute. Increased attention in the field of drug discovery has been focused on using natural compounds from traditional medicinal herbs for neuroprotection, which appears to be a promising therapeutic option for cerebral ischemia with minimal systemic adverse effects that could limit their long term use...
July 2014: Natural Product Communications
Anuradha Kalani, Pradip K Kamat, Komal Kalani, Neetu Tyagi
The epigenetic impact of curcumin in stroke and neurodegenerative disorders is curiosity-arousing. It is derived from Curcuma longa (spice), possesses anti-oxidative, anti-inflammatory, anti-lipidemic, neuro-protective and recently shown to exhibit epigenetic modulatory properties. Epigenetic studies include DNA methylation, histone modifications and RNA-based mechanisms which regulate gene expression without altering nucleotide sequences. Curcumin has been shown to affect cancer by altering epigenetic changes but its role as an epigenetic agent in cerebral stroke has not been much explored...
April 2015: Metabolic Brain Disease
Ferah Yildirim, Shengbo Ji, Golo Kronenberg, Angel Barco, Roman Olivares, Eva Benito, Ulrich Dirnagl, Karen Gertz, Matthias Endres, Christoph Harms, Andreas Meisel
Epigenetic transcriptional regulation by histone acetylation depends on the balance between histone acetyltransferase (HAT) and deacetylase activities (HDAC). Inhibition of HDAC activity provides neuroprotection, indicating that the outcome of cerebral ischemia depends crucially on the acetylation status of histones. In the present study, we characterized the changes in histone acetylation levels in ischemia models of focal cerebral ischemia and identified cAMP-response element binding protein (CREB)-binding protein (CBP) as a crucial factor in the susceptibility of neurons to ischemic stress...
2014: PloS One
Hua-Jiang Dong, Chong-Zhi Shang, Ding-Wei Peng, Jian Xu, Peng-Xiao Xu, Li Zhan, Peng Wang
Inflammatory reactions play a key role in the cerebral injury after stroke or other ischemic brain diseases. Curcumin, which is extracted from herb turmeric, has been reported to have anti-inflammatory effects. The present study was aimed to investigate the anti-inflammatory effects of curcumin on oxygen-glucose deprivation (OGD) injured brain microvascular endothelial cells (BMECs). Rat BMECs were used and the results showed that OGD induced a significant elevation of the leakage of lactate dehydrogenase and the secretion of the proinflammation cytokine, IL-1β...
September 2014: Neurological Sciences
Yunfei Pu, Hexuan Zhang, Peijian Wang, Yu Zhao, Qiang Li, Xing Wei, Yuanting Cui, Jing Sun, Qianhui Shang, Daoyan Liu, Zhiming Zhu
BACKGROUND/AIMS: Age-related cerebrovascular dysfunction contributes to stroke, cerebral amyloid angiopathy, cognitive decline and neurodegenerative diseases. One pathogenic mechanism underlying this effect is increased oxidative stress. Up-regulation of mitochondrial uncoupling protein 2 (UCP2) plays a crucial role in regulating reactive oxygen species (ROS) production. Dietary patterns are widely recognized as contributors to cardiovascular and cerebrovascular disease. In this study, we tested the hypothesis that dietary curcumin, which has an antioxidant effect, can improve aging-related cerebrovascular dysfunction via UCP2 up-regulation...
2013: Cellular Physiology and Biochemistry
T-H Chen, Y-C Yang, J-C Wang, J-J Wang
OBJECTIVES: Renal ischemia and reperfusion (I/R) injury frequently leads to acute renal failure (ARF) and multiple-organ injury with a substantial morbidity rate. The primary cause of ARF-associated death is, however, cardiac failure instead of renal failure itself, and the pathogenesis of renal I/R-induced cardiac injury is still poorly understood. We evaluated the efficacy of curcumin pretreatment on cardioprotection. METHODS: Thirty Sprague-Dawley rats were evenly divided into 3 groups of sham-operated control, renal I/R injury, and a curcumin pretreatment group...
2013: Transplantation Proceedings
Niyaz Ahmad, Sadiq Umar, Mohammad Ashafaq, Mohd Akhtar, Zeenat Iqbal, Mohd Samim, Farhan Jalees Ahmad
Oxidative stress and inflammatory damage play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. The development of new strategies for enhancing drug delivery to the brain is of great importance in diagnostics and therapeutics of central nervous diseases. The present study examined the hypothesis that intranasal delivery of nanoformulation of curcuminoids would reduce oxidative stress-associated brain injury after middle cerebral artery occlusion (MCAO). The rats were subjected to 2 h of MCAO followed by 22 h reperfusion, after which the grip strength, locomotor activity was performed...
December 2013: Protoplasma
Mohammad Nabiuni, Zahra Nazari, Zahra Safaeinejad, Bahram Delfan, Jaleel A Miyan
Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure. Blockade of AQP1 in the CP reduce the production of cerebrospinal fluid (CSF). Downregulation of AQP1 might be protective against some neurological disorders correlated with increased intracranial pressure and/or poor drainage of CSF. Curcumin, the major constituent of the rhizome of Curcuma longa, has been shown to inhibit potassium channels, Na⁺-K⁺ ATPase, as well as AQP3 in some cells...
June 2013: Journal of Medicinal Food
Jeffrey M Witkin, Xia Li
The root extract, curcumin (diferuloylmethane), is a constituent of the ancient herbal medicine Jiawei-Xiaoyaosan that has been used for dyspepsia, stress, and mood disorders. Curcumin engenders a diverse profile of biological actions that result in changes in oxidative stress, inflammation, and cell-death pathways. Combined with its historical use in medical practice and its safety profile, curcumin has been studied for its potential therapeutic applications in cancer, aging, endocrine, immunological, gastrointestinal, and cardiac diseases...
June 2013: CNS & Neurological Disorders Drug Targets
Jingxian Wu, Qiong Li, Xiaoyan Wang, Shanshan Yu, Lan Li, Xuemei Wu, Yanlin Chen, Jing Zhao, Yong Zhao
Oxidative damage plays a critical role in many diseases of the central nervous system. This study was conducted to determine the molecular mechanisms involved in the putative anti-oxidative effects of curcumin against experimental stroke. Oxygen and glucose deprivation/reoxygenation (OGD/R) was used to mimic ischemic insult in primary cultured cortical neurons. A rapid increase in the intracellular expression of NAD(P)H: quinone oxidoreductase1 (NQO1) induced by OGD was counteracted by curcumin post-treatment, which paralleled attenuated cell injury...
2013: PloS One
Janet L Funk, Jennifer B Frye, Grace Davis-Gorman, Allison L Spera, Michael J Bernas, Marlys H Witte, Martin E Weinand, Barbaba N Timmermann, Paul F McDonagh, Leslie Ritter
OBJECTIVE: We sought to test the hypothesis that turmeric-derived curcuminoids limit reperfusion brain injury in an experimental model of stroke via blockade of early microvascular inflammation during reperfusion. METHODS: Male Sprague Dawley rats subjected to MCAO/R were treated with turmeric-derived curcuminoids (vs. vehicle) 1 hour prior to reperfusion (300 mg/kg ip). Neutrophil adhesion to the cerebral microcirculation and measures of neutrophil and endothelial activation were assayed during early reperfusion (0-4 hours); cerebral infarct size, edema, and neurological function were assessed at 24 hours...
August 2013: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Cheng Yang, Keng Wu, Shang-Hai Li, Qiong You
CONTEXT: The heart is one of the target organs susceptible to attack by sepsis, and protection of the cardiac function in sepsis or alleviation dysfunction caused by sepsis appears a serious and urgent problem. OBJECTIVE: This study was designed to explore the effect of curcumin on myocardial injury induced by sepsis and to explore the therapeutic effect of curcumin in managing sepsis induced cardiac dysfunction. METHODS: Cecal ligation and puncture surgery were used to establish the sepsis model...
April 2013: Pharmaceutical Biology
Aisha I Kelly-Cobbs, Roshini Prakash, Weiguo Li, Bindu Pillai, Sherif Hafez, Maha Coucha, Maribeth H Johnson, Safia N Ogbi, Susan C Fagan, Adviye Ergul
Hemorrhagic transformation is an important complication of acute ischemic stroke, particularly in diabetic patients receiving thrombolytic treatment with tissue plasminogen activator, the only approved drug for the treatment of acute ischemic stroke. The objective of the present study was to determine the effects of acute manipulation of potential targets for vascular protection [i.e., NF-κB, peroxynitrite, and matrix metalloproteinases (MMPs)] on vascular injury and functional outcome in a diabetic model of cerebral ischemia...
March 15, 2013: American Journal of Physiology. Heart and Circulatory Physiology
Ning-Ping Wang, Zhang-Feng Wang, Stephanie Tootle, Tiji Philip, Zhi-Qing Zhao
BACKGROUND AND PURPOSE: Curcumin, the natural yellow pigment extracted from the rhizomes of the plant curcuma longa, has been demonstrated to exhibit a variety of potent beneficial effects, acting as an antioxidant, anti-inflammatory and anti-fibrotic. In this study we tested the hypothesis that curcumin attenuates maladaptive cardiac repair and improves cardiac function after ischaemia and reperfusion by reducing degradation of extracellular matrix (ECM) and inhibiting synthesis of collagens via TGFβ/Smad-mediated signalling pathway...
December 2012: British Journal of Pharmacology
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