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Trigeminal neuralgia and nerve

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https://www.readbyqxmd.com/read/28236840/primary-trigeminal-neuralgia-and-the-role-of-pars-oralis-of-the-spinal-trigeminal-nucleus
#1
Selcuk Peker, Alperen Sirin
Trigeminal neuralgia is a painful condition that causes great discomfort. Although this disease has been known for more than 1000years, there is still no consensus on its underlying mechanism or treatment. Many hypotheses have been reported to explain the cause and nature of trigeminal neuralgia. These include theories about peripheral mechanisms and central mechanisms. We put forward a new hypothesis that trigeminal neuralgia is associated with the pars oralis of the spinal trigeminal nucleus (POSTN). The main basis for this is the close similarity between trigger point distribution and the area of influence of the POSTN...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28235509/management-of-isolated-infraorbital-neuralgia-by-ultrasound-guided-infraorbital-nerve-block-with-combination-of-steroid-and-local-anesthetic
#2
Oya Y Cok, Sinan Deniz, H Evren Eker, Levent Oguzkurt, Anis Aribogan
Patients with isolated peripheral branch neuralgia of trigeminal nerve usually receive traditional treatment such as medical therapy and interventional procedures targeting the entire trigeminal nerve or related ganglions. However, if the intractable pain is limited to a certain branch, the patient may also benefit from a peripheral and nerve-targeted interventional approach. Here, we report the management of a patient with isolated infraorbital neuralgia by ultrasound-guided infraorbital nerve block with steroid and local anesthetic combination...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28223844/neuronal-plasticity-of-trigeminal-ganglia-in-mice-following-nerve-injury
#3
Randi Lynds, Chuang Lyu, Gong-Wei Lyu, Xie-Qi Shi, Annika Rosén, Kamal Mustafa, Tie-Jun Sten Shi
BACKGROUND: Nerve injury may induce neuropathic pain. In studying the mechanisms of orofacial neuropathic pain, attention has been paid to the plastic changes that occur in the trigeminal ganglia (TGs) and nucleus in response to an injury of the trigeminal nerve branches. Previous studies have explored the impact of sciatic nerve injury on dorsal root ganglia (DRGs) and it has shown dramatic changes in the expression of multiple biomarkers. In large, the changes in biomarker expression in TGs after trigeminal nerve injury are similar to that in DRGs after sciatic nerve injury...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28217812/-effects-of-tetramethylpyrazine-on-trigeminal-neuralgia-induced-by-chronic-constriction-injury-of-infraorbital-nerve-in-rats
#4
Meng-Xia Tan, Wei Xiong, Ling-Kun He, Ling-Kun He, Guo Yang, Li-Ping Huang, Yu-Lin Shen, Shang-Dong Liang, Yun Gao
Trigeminal neuralgia (TN) is a kind of recurrent transient and severe pain that is limited to the trigeminal nerve in one or more branches. The clinical incidence of TN is high, which seriously affects the quality of life of the patients and is difficult to cure. The present study investigated the effects of tetramethylpyrazine (TMP) on TN induced by chronic constriction injury of the infraorbital nerve (ION-CCI) in rats. Adult male Sprague-Dawley rats were randomly assigned to four groups: sham, sham treated with TMP (Sham+TMP), TN model (TN), and TN treated with TMP (TN+TMP)...
February 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28203025/-trigemino-cardiac-reflex-in-skull-base-surgery
#5
H Z Duan, Y Zhang, L Li, J Y Zhang, Z Q Yi, S D Bao
OBJECTIVE: To explore the mechanism, clinical features, and prognosis of Trigemino-cardiac reflex (TCR) during skull base operations. METHODS: A retrospective analysis was performed on 291 patients with skull base disease from Jan. 2009 to Oct. 2015 in Peking University First Hospital. By reviewing the patients' operative data and anaesthetic electrical record, and we picked out all the patients who suffered from TCR during the operation and analyzed their surgical procedures, clinical features, influence factors, and prognosis...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28184169/differential-drug-effects-on-spontaneous-and-evoked-pain-behavior-in-a-model-of-trigeminal-neuropathic-pain
#6
K Deseure, G H Hans
PURPOSE: Baclofen and morphine have shown efficacy against mechanical allodynia after infraorbital nerve chronic constriction injury (IoN-CCI). No drug effects have yet been reported on spontaneous trigeminal neuropathic pain. It has been proposed that the directed face grooming behavior that also develops following IoN-CCI offers a measure of spontaneous trigeminal neuropathic pain. SUBJECTS AND METHODS: We examined the effects of a continuous 1-week infusion of 30 mg/day carbamazepine (the first-line drug treatment for trigeminal neuralgia), 1...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28175487/190%C3%A2-a-comparative-analysis-of-operative-and-radiographic-findings-of-neurovascular-compression-of-the-trigeminal-nerve-in-patients-without-trigeminal-neuralgia
#7
Raymond F Sekula, Marion Hughes, Hossein Mousavi
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28162635/-389-treatment-of-refractory-trigeminal-neuralgia-caused-by-head-and-neck-radiation-with-ultrasound-guided-trigeminal-nerve-block
#8
A Ebrahimi, A Nader, M Kendall
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28158167/the-rare-painful-phenomena-chronic-paroxysmal-hemicrania-tic-syndrome-as-a-clinically-isolated-syndrome-of-the-central-nervous-system
#9
Srdjan Ljubisavljevic, Ana Prazic, Miodrag Lazarevic, Dragan Stojanov, Dejan Savic, Slobadan Vojinovic
The association of paroxysmal hemicrania with trigeminal neuralgia (TN) has been described and called paroxysmal hemicrania-tic syndrome (PH-tic). We report the case of a patient diagnosed as having chronic PH-tic (CPH-tic) syndrome as a clinically isolated syndrome of the central nervous system (CNS) (CIS).A forty year old woman was admitted to our hospital suffering from right facial pain for the last 2 years. The attacks were paroxysmal, neuralgiform, consisting of throb-like sensations, which developed spontaneously or were triggered by different stimuli in right facial (maxilar and mandibular) areas...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28158153/trigeminal-neuralgia-induced-by-cobra-venom-leads-to-cognitive-deficits-associated-with-downregulation-of-creb-bdnf-pathway
#10
Li Zhang, Xinli Ding, Zhe Wu, Xiaoyan Qian, Jianxiong An, Ming Tian
BACKGROUND: Chronic pain often results in cognitive impairment. Our previous study showed that trigeminal neuralgia induced by cobra venom leads to spatial learning and memory deficits, although the underlying mechanism remains unclear. However, recent evidence indicates that the c-AMP-responsive element binding protein (CREB)/brain derived neurotrophic factor (BDNF) pathway plays a critical role in various etiologies of cognitive deficits. OBJECTIVES: Our aim was to explore the CREB/BDNF pathway to determine the molecular mechanisms involved in the pathogenesis of cognitive impairment caused by cobra venom-induced trigeminal neuralgia...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28140499/deterministic-tractography-of-the-descending-tract-of-the-spinal-trigeminal-nerve-using-diffusion-tensor-imaging
#11
Daniel J Burkett, Jonathan R Garst, Jacquelyn P Hill, Anthony Kam, Douglas E Anderson
BACKGROUND AND PURPOSE: Pain information from the face enters the pons via the trigeminal nerve before creating an anatomical "elbow" that turns caudally into the spinal trigeminal tract (SpTV). Visualization of the descending tract of the trigeminal nerve as it begins its descent from the nerve root entry zone (NREZ) in the pons would improve the accuracy of current procedures aimed at altering or lesioning the trigeminal nerve within the brainstem. The focus of this study was to develop a standardized protocol using diffusion tensor imaging (DTI) and deterministic tractography methods to image the SpTV...
January 31, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28138306/trigeminal-nerve-block-with-alcohol-for-medically-intractable-classic-trigeminal-neuralgia-long-term-clinical-effectiveness-on-pain
#12
Kyung Ream Han, Yun Jeong Chae, Jung Dong Lee, Chan Kim
BACKGROUND: Trigeminal nerve block (Tnb) with alcohol for trigeminal neuralgia (TN) may not be used widely as a percutaneous procedure for medically intractable TN in recent clinical work, because it has been considered having a limited duration of pain relief, a decrease in success rate and increase in complications on repeated blocks. OBJECTIVES: To evaluate the clinical outcome of the Tnb with alcohol in the treatment of medically intractable TN. METHODS: Six hundred thirty-two patients were diagnosed with TN between March 2000 and February 2010...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28137525/hypericum-perforatum-st-john-s-wort-as-a-possible-therapeutic-alternative-for-the-management-of-trigeminal-neuralgia-tn-a-case-report
#13
Khalil Assiri, Yagoub Alyami, James M Uyanik, Marcela Romero-Reyes
Hypericum perforatum (St. John's Wort) is an alternative remedy used primarily for depression but also is used for rheumatism, gastroenteritis, headache and neuralgias. The mechanism of action of Hypericum perforatum comprehends a neurotransmitter inhibitory profile, and potential anti-inflammatory and anti-oxidant effects suggesting a role for pain management. In this case report, we describe a 53-year-old Hispanic female patient who came to our orofacial pain clinical service presenting with a history of trigeminal neuralgia (TN)...
February 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28134648/symptomatic-trigeminal-neuralgia-caused-by-cerebellopontine-angle-tumors
#14
Pengfei Liu, Chenlong Liao, Wenxiang Zhong, Min Yang, Shiting Li, Wenchuan Zhang
To investigate the characteristics of symptomatic trigeminal neuralgia (TN) caused by tumors and the relationship between anatomicosurgical findings and tumor type, the authors undertook a retrospective review of 35 patients with symptomatic TN between 2006 and 2015. The tumors included 16 meningiomas, 14 epidermoids, 4 vestibular schwannomas, and 1 hemangioblastoma. The studies show that patients with tumor-induced TN were significantly younger than those idiopathic TN (P <0.05). Meningioma-induced TN tended to have responsible vessels, while epidermoid tumor seemed to cause TN by wrapping or compressing the nerve...
January 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28133989/other-facial-neuralgias
#15
Francis O'Neill, Turo Nurmikko, Claudia Sommer
Premise In this article we review some lesser known cranial neuralgias that are distinct from trigeminal neuralgia, trigeminal autonomic cephalalgias, or trigeminal neuropathies. Included are occipital neuralgia, superior laryngeal neuralgia, auriculotemporal neuralgia, glossopharyngeal and nervus intermedius neuralgia, and pain from acute herpes zoster and postherpetic neuralgia of the trigeminal and intermedius nerves. Problem Facial neuralgias are rare and many physicians do not see such cases in their lifetime, so patients with a suspected diagnosis within this group should be referred to a specialized center where multidisciplinary team diagnosis may be available...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28122347/after-microvascular-decompression-to-treat-trigeminal-neuralgia-both-immediate-pain-relief-and-recurrence-rates-are-higher-in-patients-with-arterial-compression-than-with-venous-compression
#16
Lei Shi, Xiaoyan Gu, Guan Sun, Jun Guo, Xin Lin, Shuguang Zhang, Chunfa Qian
We explored differences in postoperative pain relief achieved through decompression of the trigeminal nerve compressed by arteries and veins. Clinical characteristics, intraoperative findings, and postoperative curative effects were analyzed in 72 patients with trigeminal neuralgia who were treated by microvascular decompression. The patients were divided into arterial and venous compression groups based on intraoperative findings. Surgical curative effects included immediate relief, delayed relief, obvious reduction, and invalid result...
January 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28118416/topical-review-potential-use-of-botulinum-toxin-in-the-management-of-painful-posttraumatic-trigeminal-neuropathy
#17
Nathan Moreau, Wisam Dieb, Vianney Descroix, Peter Svensson, Malin Ernberg, Yves Boucher
Painful posttraumatic trigeminal neuropathy (PPTTN) is a chronic condition that is difficult to endure and has a poorly understood pathophysiology. Treatment options are limited and often unsatisfactory due to insufficient efficacy and significant adverse effects. Botulinum toxin type A (BTX-A), initially used in the management of pathologically sustained or twisting muscular contractions, has recently been advocated for treatment of neuropathic pain. Its action is not limited to the blockage of acetylcholine release at the neuromuscular junction, but also includes inhibition of exocytosis of other neurotransmitters by interfering with the SNARE complexes of synaptic membranes...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28110929/de-novo-superior-cerebellar-artery-aneurysm-following-radiosurgery-for-trigeminal-neuralgia
#18
Joseph C T Chen, Kuo Chao, Javad Rahimian
Stereotactic radiosurgery is a commonly used method for treatment of trigeminal neuralgia. Radiation has been known to be a factor in the later development of aneurysms. Aneurysms have been reported to occur after radiation delivered in a variety of methods including both externally delivered radiation radiosurgery and brachytherapy. We report here an incidence of a de novo aneurysm presenting following radiosurgery treatment for trigeminal neuralgia. The patient was treated using frame-based LINAC radiosurgery receiving 90Gy to the mid cisternal extent of the nerve via a 4mm conical collimator...
January 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28097083/recurrent-squamous-cell-carcinoma-of-the-eyelid-presenting-as-trigeminal-neuralgia
#19
Nicole Spitzer, Naazli Shaikh, Leah Strickland, Son Ho
This paper describes two patients with squamous cell carcinoma (SCC) of the periocular and periorbital skin who presented with trigeminal neuralgia. Both patients had previous cutaneous SCC of the scalp treated successfully with surgical resection but later presented with neuro-ophthalmic findings suggesting perineural invasion (PNI) of SCC. PNI of SCC in the periocular skin or orbit can lead to devastating effects if malignant cells seed into the orbit and adjacent cranial nerves as our two patients developed an orbital apex syndrome...
December 16, 2016: Curēus
https://www.readbyqxmd.com/read/28087952/an-observational-study-of-trigeminal-neuralgia-patients-taking-carbamazepine-during-the-fasting-month-of-ramadan
#20
A J Ajura, S H Lau, S Nur Suffia
INTRODUCTION: Trigeminal neuralgia is an agonising orofacial pain affecting unilaterally the distribution of the trigeminal nerve and it usually occurs in the middle and older age groups. Carbamazepine which is an anti-neuralgic as well as an anti-convulsant medication is the first line drug for treatment of trigeminal neuralgia. It is commonly taken as one tablet (200 mg) three times a day. MATERIALS AND METHODS: This is an observational study carried out from April to September 2014 to determine how Muslim patients on carbamazepine treatment for trigeminal neuralgia cope with their neuralgic pain...
December 2016: Medical Journal of Malaysia
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