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https://www.readbyqxmd.com/read/29907780/effects-of-8-week-sensory-electrical-stimulation-combined-with-motor-training-on-eeg-emg-coherence-and-motor-function-in-individuals-with-stroke
#1
Li-Ling Hope Pan, Wen-Wen Yang, Chung-Lan Kao, Mei-Wun Tsai, Shun-Hwa Wei, Felipe Fregni, Vincent Chiun-Fan Chen, Li-Wei Chou
The peripheral sensory system is critical to regulating motor plasticity and motor recovery. Peripheral electrical stimulation (ES) can generate constant and adequate sensory input to influence the excitability of the motor cortex. The aim of this proof of concept study was to assess whether ES prior to each hand function training session for eight weeks can better improve neuromuscular control and hand function in chronic stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES)...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29905857/gfpt1-deficiency-in-muscle-leads-to-myasthenia-and-myopathy-in-mice
#2
Yasmin Issop, Denisa Hathazi, Muzamil Majid Khan, Rüdiger Rudolf, Joachim Weis, Sally Spendiff, Clarke R Slater, Andreas Roos, Hanns Lochmüller
Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is the rate-limiting enzyme in the hexosamine biosynthetic pathway which yields precursors required for protein and lipid glycosylation. Mutations in GFPT1 and other genes downstream of this pathway cause congenital myasthenic syndrome (CMS) characterised by fatigable muscle weakness due to impaired neurotransmission. The precise pathomechanisms at the neuromuscular junction (NMJ) due to a deficiency in GFPT1 is yet to be discovered. One of the challenges we face is the viability of Gfpt1 -/- knockout mice...
June 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29904285/sugammadex-appropriate-use-in-the-context-of-budgetary-constraints
#3
REVIEW
Guy Cammu
Purpose of Review: The purpose of this review is to assess how sugammadex impacts postoperative residual curarization using appropriate doses based on neuromuscular transmission monitoring and whether the advantages of sugammadex versus neostigmine outweigh its higher cost. Recent Findings: An accurate assessment of neuromuscular blockade with monitoring is necessary before selecting neostigmine versus sugammadex for reversal at the end of surgery to overcome incomplete neuromuscular recovery...
2018: Current Anesthesiology Reports
https://www.readbyqxmd.com/read/29904284/new-drug-developments-for-neuromuscular-blockade-and-reversal-gantacurium-cw002-cw011-and-calabadion
#4
REVIEW
Hans Donald de Boer, Ricardo Vieira Carlos
Purpose of Review: The purpose of this chapter is to provide a brief review of the literature on the recent developments in neuromuscular blockade and reversal agents. Recent Findings: Novel drug development resulted in pharmacological advancements in neuromuscular management and led to a new series of compounds, chlorofumarates, such as gantacurium, CW002, and CW011. These drugs have a fast onset and rapid to intermediate duration of action and can be rapidly reversed by l-cysteine adduction without side effects that are commonly observed with anticholinesterase reversal drugs...
2018: Current Anesthesiology Reports
https://www.readbyqxmd.com/read/29903643/the-use-of-neuromuscular-electrical-stimulation-nmes-for-managing-the-complications-of-ageing-related-to-reduced-exercise-participation
#5
REVIEW
Dominic O'Connor, Louise Brennan, Brian Caulfield
Exercise participation and activity levels are low in many older adults, and when paired with the multi-systemic effects of ageing, such as sarcopenia and decreased cardiovascular function, can result in a loss of functional independence. Voluntary exercise may not always be feasible for these individuals, highlighting a need for alternative therapies. There is a growing body of literature that recognises the positive effects of neuromuscular electrical stimulation (NMES) on muscle strength, muscle mass and cardiorespiratory function in older adults...
July 2018: Maturitas
https://www.readbyqxmd.com/read/29903623/immune-checkpoint-mediated-myositis-and-myasthenia-gravis-a-case-report-and-review-of-evaluation-and-management
#6
Kylie H Kang, William Grubb, Komal Sawlani, Michael K Gibson, Christopher J Hoimes, Lisa R Rogers, Pierre Lavertu, Min Yao
BACKGROUND: We present a case of myositis and possible overlapping neuromuscular junction disorder following treatment with nivolumab for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). METHODS: We report a 75-year-old man with recurrent stage IVA, T1N2cM0 oral cavity HNSCC treated with weight-dosed nivolumab who presented three weeks later with severe fatigue, generalized weakness, and bilateral ptosis. Evaluation demonstrated elevated creatine kinase and myopathic motor units on electromyography, supporting a diagnosis of an underlying muscle disease...
June 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29903600/revisiting-extracorporeal-membrane-oxygenation-for-ards-in-burns-a-case-series-and-review-of-the-literature
#7
Craig R Ainsworth, Jeffrey Dellavolpe, Kevin K Chung, Leopoldo C Cancio, Phillip Mason
INTRODUCTION: Recent reports on the use of extracorporeal membrane oxygenation (ECMO) in critically ill burn patients with Acute Respiratory Distress Syndrome (ARDS) recommended against the use of ECMO. The authors cited the high mortality rates associated with the use of ECMO in these patients with no appreciable benefit. Accumulating evidence from referral centers suggests improved survival in patients with ARDS receiving ECMO. We report our recent experience treating patients with severe ARDS with ECMO in a burn intensive care unit...
June 11, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29902705/the-effect-of-eccentric-exercise-and-delayed-onset-muscle-soreness-on-the-homologous-muscle-of-the-contralateral-limb
#8
Nosratollah Hedayatpour, Zahra Izanloo, Deborah Falla
High intensity eccentric exercise induces muscle fiber damage and associated delayed-onset muscle soreness (DOMS) resulting in an impaired ability of the muscle to generate voluntary force. This study investigates the extent to which DOMS, induced by high intensity eccentric exercise, can affect the activation and performance of the non-exercised homologous muscle of the contralateral limb. Healthy volunteers performed maximal voluntary contractions of knee extension and sustained isometric knee extension at 50% of maximal force until task failure on both the ipsilateral exercised limb and the contralateral limb...
June 6, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29902280/automatic-characterization-of-stride-parameters-in-canines-with-a-single-wearable-inertial-sensor
#9
Gregory J Jenkins, Chady H Hakim, N Nora Yang, Gang Yao, Dongsheng Duan
BACKGROUND AND OBJECTIVE: Gait analysis is valuable for studying neuromuscular and skeletal diseases. Wearable motion sensors or inertial measurement units (IMUs) have become common for human gait analysis. Canines are important large animal models for translational research of human diseases. Our objective is to develop a method for accurate and reliable determination of the timing of each stride in dogs using a wearable IMU. METHODS: We built a wireless IMU sensor using off-the-shelf components...
2018: PloS One
https://www.readbyqxmd.com/read/29901600/determining-the-burden-of-the-family-caregivers-of-people-with-neuromuscular-diseases-who-use-a-wheelchair
#10
Thais Pousada, Betania Groba, Laura Nieto-Riveiro, Alejandro Pazos, Emiliano Díez, Javier Pereira
The present study provides a basic outline of the care and support that family caregivers offer to people affected by neuromuscular diseases.To determine the presence of burden in caregivers of people with neuromuscular diseases who use a wheelchair and to establish whether the presence of burden is influenced by contextual factors, between them, the use of wheelchair.The applied design was cross-sectional and descriptive. The data were collected through a specific questionnaire, the Functional Independence Measure, the Matching Person and Technology form and the Zarit Burden Interview...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901439/tenectin-recruits-integrin-to-stabilize-bouton-architecture-and-regulate-vesicle-release-at-the-drosophila-neuromuscular-junction
#11
Qi Wang, Tae Hee Han, Peter Nguyen, Michal Jarnik, Mihaela Serpe
Assembly, maintenance and function of synaptic junctions depend on extracellular matrix (ECM) proteins and their receptors. Here we report that Tenectin (Tnc), a Mucin-type protein with RGD motifs, is an ECM component required for the structural and functional integrity of synaptic specializations at the neuromuscular junction (NMJ) in Drosophila. Using genetics, biochemistry, electrophysiology, histology and electron microscopy, we show that Tnc is secreted from motor neurons and striated muscles and accumulates in the synaptic cleft...
June 14, 2018: ELife
https://www.readbyqxmd.com/read/29900767/anesthesia-of-aquarium-housed-walrus-odobenus-rosmarus-a-case-series
#12
Johanna Kaartinen, Stéphane Lair, Michael T Walsh, Patrick Burns, Marion Desmarchelier, Jessica M Pang, Daniel S J Pang
  Walruses are a challenging species to anesthetize as a result of their large mass, limited access for drug delivery, unique physiology, and small number of reports describing anesthetic procedures. Three aquarium-housed walruses ( Odobenus rosmarus) ranging in age from 3 to 11 yr old (344-1,000 kg) were anesthetized for dental or ophthalmic surgical procedures, with one animal anesthetized twice and one anesthetized three times. Preanesthetic medication was with intramuscular midazolam (0.1-0.2 mg/kg) and meperidine (2-3 mg/kg)...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29899727/flecainide-induced-brugada-syndrome-in-a-patient-with-skeletal-muscle-sodium-channelopathy-a-case-report-with-critical-therapeutical-implications-and-review-of-the-literature
#13
Michele Cavalli, Barbara Fossati, Raffaele Vitale, Elisa Brigonzi, Vito A G Ricigliano, Lorenzo Saraceno, Rosanna Cardani, Carlo Pappone, Giovanni Meola
Skeletal muscle sodium channelopathies are a group of neuromuscular disorders associated with mutations in the SCN4A gene. Because principal sodium channel isoforms expressed in the skeletal muscles and the heart are distinct one from the other, this condition usually spares cardiac functioning. Nonetheless, evidence on a possible link between skeletal muscle and cardiac sodium channelopathies has emerged in recent years. To date, eight patients bearing pathogenetic mutations in the SCN4A gene and manifesting cardiac electrophysiological alterations have been reported in literature...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29899726/a-role-for-gdnf-and-soluble-app-as-biomarkers-of-amyotrophic-lateral-sclerosis-pathophysiology
#14
Serena Stanga, Liliana Brambilla, Bernadette Tasiaux, Anh H Dang, Adrian Ivanoiu, Jean-Noël Octave, Daniela Rossi, Vincent van Pesch, Pascal Kienlen-Campard
The current inability of clinical criteria to accurately identify the "at-risk group" for Amyotrophic Lateral Sclerosis (ALS) development as well as its unknown etiology are fueling the interest in biomarkers aimed at completing clinical approaches for the diagnosis. The Glial cell line-derived neurotrophic factor (GDNF) is a diffusible peptide critically involved in neuronal differentiation and survival. GDNF is largely studied in various neurological and neuromuscular diseases, with a great interest in the peripheral nervous system (PNS)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29899705/age-and-sex-related-differences-in-motor-performance-during-sustained-maximal-voluntary-contraction-of-the-first-dorsal-interosseous
#15
Valerie Sars, Roeland F Prak, Tibor Hortobágyi, Inge Zijdewind
Age and sex affect the neuromuscular system including performance fatigability. Data on performance fatigability and underlying mechanisms in hand muscles are scarce. Therefore, we determined the effects of age and sex on force decline, and the mechanisms contributing to force decline, during a sustained isometric maximal voluntary contraction (MVC) with the index finger abductor (first dorsal interosseous, FDI). Subjects ( n = 51, age range: 19-77 years, 25 females) performed brief and a 2-min sustained MVC with the right FDI...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29898954/mitofusin-gain-and-loss-of-function-drive-pathogenesis-in-drosophila-models-of-cmt2a-neuropathy
#16
Najla El Fissi, Manuel Rojo, Aїcha Aouane, Esra Karatas, Gabriela Poliacikova, Claudine David, Julien Royet, Thomas Rival
Charcot-Marie-Tooth disease type 2A (CMT2A) is caused by dominant alleles of the mitochondrial pro-fusion factor Mitofusin 2 (MFN2). To address the consequences of these mutations on mitofusin activity and neuronal function, we generate Drosophila models expressing in neurons the two most frequent substitutions (R94Q and R364W, the latter never studied before) and two others localizing to similar domains (T105M and L76P). All alleles trigger locomotor deficits associated with mitochondrial depletion at neuromuscular junctions, decreased oxidative metabolism and increased mtDNA mutations, but they differently alter mitochondrial morphology and organization...
June 13, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29898669/morphology-of-the-bryozoan-cinctipora-elegans-cyclostomata-cinctiporidae-with-first-data-on-its-sexual-reproduction-and-the-cyclostome-neuro-muscular-system
#17
Thomas F Schwaha, Stephan Handschuh, Andrew N Ostrovsky, Andreas Wanninger
BACKGROUND: Cyclostome bryozoans are an ancient group of marine colonial suspension-feeders comprising approximately 700 extant species. Previous morphological studies are mainly restricted to skeletal characters whereas data on soft tissues obtained by state-of-the-art methods are still lacking. In order to contribute to issues related to cyclostome ground pattern reconstruction, we analyzed the morphology of the neuromuscular system Cinctipora elegans by means of immunocytochemical staining, confocal laser scanning microscopy, histological sections and microCT imaging...
June 14, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29897452/pre-clinical-symptoms-of-sbma-may-not-be-androgen-dependent-implications-from-two-sbma-mouse-models
#18
Youfen Xu, Katherine Halievski, Masahisa Katsuno, Hiroaki Adachi, Gen Sobue, S Marc Breedlove, Cynthia L Jordan
A distinguishing aspect of spinal bulbar muscular atrophy (SBMA) is its androgen-dependence, possibly explaining why only males are clinically affected. This disease, which impairs neuromuscular function, is linked to a polyglutamine expansion mutation in the androgen receptor (AR). In mouse models of SBMA, motor dysfunction is associated with pronounced defects in neuromuscular transmission, including defects in evoked transmitter release (quantal content, QC) and fiber membrane excitability (based on the resting membrane potential, RMP)...
April 20, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29897309/great-toe-drop-following-knee-ligament-reconstruction-a-case-report
#19
David A Boyce, Chantal Prewitt
CASE DESCRIPTION: A 17-year-old male post anterior cruciate ligament reconstruction complained of the inability to extend his great toe immediately following surgery. BACKGROUND: Neurological injuries following knee arthroscopy have been reported to occur between 0.6%-2.5%. The most commonly injured nerves are the saphenous and common fibular nerve (CFN). Great toe-drop secondary to isolated denervation of the extensor hallucis longus (EHL), has only been reported one time in the literature...
June 13, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29896116/plyometrics-can-preserve-peak-power-during-2-months-of-physical-inactivity-an-rct-including-a-one-year-follow-up
#20
Andreas Kramer, Jakob Kümmel, Albert Gollhofer, Gabriele Armbrecht, Ramona Ritzmann, Daniel Belavy, Dieter Felsenberg, Markus Gruber
Objective: Inactivity results in a marked loss of muscle function, especially in movements requiring high power, force, and rate of force development. The aim of the present study was to evaluate if jump training can prevent these deteriorating effects of physical inactivity. Methods: Performance and muscle activity during several types of jumps was assessed directly before and after 60 days of bed rest as well as during follow-up visits in 23 male participants. Participants in the jump training group (JUMP, 12 participants) trained 5-6x per week during the bed rest period in a sledge jump system that allows jumps in a horizontal position, whereas the control group (CTRL, 11 participants) did not train...
2018: Frontiers in Physiology
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