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https://www.readbyqxmd.com/read/29774400/cost-effectiveness-of-osteoporosis-screening-strategies-for-hip-fracture-prevention-in-older-chinese-people-a-decision-tree-modeling-study-in-the-mr-os-and-ms-os-cohort-in-hong-kong
#1
Y Su, F T T Lai, B H K Yip, J C S Leung, T C Y Kwok
Despite the high costs of hip fracture, many governments provide limited support for osteoporosis screening. We demonstrated that osteoporosis screening by dual-energy X-ray absorptiometry (DXA) with or without pre-screening by Fracture Risk Assessment Tool (FRAX) or calcaneal ultrasound are more cost-effective than no screening in Chinese people aged 65 or over in Hong Kong. INTRODUCTION: To examine the cost-effective potential osteoporosis screening strategies for hip fracture prevention in Hong Kong...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29752481/publisher-correction-the-c-terminal-tails-of-endogenous-glua1-and-glua2-differentially-contribute-to-hippocampal-synaptic-plasticity-and-learning
#2
Zikai Zhou, An Liu, Shuting Xia, Celeste Leung, Junxia Qi, Yanghong Meng, Wei Xie, Pojeong Park, Graham L Collingridge, Zhengping Jia
In the version of this article initially published, the wrong version of Supplementary Fig. 10 was posted and the city for affiliation 4, the Co-innovation Center of Neuroregeneration, Nantong University, was given as Nanjing instead of Nantong. The errors have been corrected in the HTML and PDF versions of the article.
May 11, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29740362/you-are-what-you-read-the-belief-systems-of-cyber-bystanders-on-social-networking-sites
#3
Angel N M Leung, Natalie Wong, JoAnn M Farver
The present study tested how exposure to two types of responses to a hypothetical simulated Facebook setting influenced cyber-bystanders' perceived control and normative beliefs using a 4 cyberbully-victim group (pure cyberbullies, non-involved, pure cyberbullied victims, and cyberbullied-victims) × 2 condition (offend vs. defend) experimental design. 203 Hong Kong Chinese secondary school and university students (132 females, 71 males; 12 to 28; M = 16.70; SD = 3.03 years old) were randomly assigned into one of two conditions...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29685141/sinew-acupuncture-for-knee-osteoarthritis-study-protocol-for-a-randomized-sham-controlled-trial
#4
Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea, Lixing Lao
BACKGROUND: Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational study revealed that sinew acupuncture has immediate analgesic effects on various soft tissue injuries, including knee injuries. However, no rigorous trials have been conducted. This study aims to examine whether sinew acupuncture can safely relieve pain and symptoms of knee osteoarthritis (KOA) and improve patients' functional movement and quality of life...
April 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29623871/health-promoting-lifestyle-and-quality-of-life-among-chinese-nursing-students
#5
Yim Wah Mak, Angela H F Kao, Lucia W Y Tam, Virginia W C Tse, Don T H Tse, Doris Y P Leung
AimThis study aimed to examine the relationships between socio-economic status, health-promoting lifestyles, and quality of life among Chinese nursing students. BACKGROUND: Nursing students will be future health promoters, but they may not always adopt the recommended healthy lifestyle. Currently, there are insufficient studies examining the health-promoting lifestyles of Chinese nursing students, and the impact of socio-economic status and health-promoting lifestyle on their health. METHODS: This was a cross-sectional survey...
April 6, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29593017/electroacupuncture-plus-standard-of-care-for-managing-refractory-functional-dyspepsia-protocol-of-a-pragmatic-trial-with-economic-evaluation
#6
Vincent C H Chung, Charlene H L Wong, Jessica Y L Ching, Wai Zhu Sun, Yan Li Ju, Sheung Sheung Hung, Wai Ling Lin, Ka Chun Leung, Samuel Y S Wong, Justin C Y Wu
INTRODUCTION: This trial proposes to compare the effectiveness and cost-effectiveness of electroacupuncture (EA) plus on-demand gastrocaine with waiting list for EA plus on-demand gastrocaine in providing symptom relief and quality-of-life improvement among patients with functional dyspepsia (FD). METHODS AND ANALYSIS: This is a single-centre, pragmatic, randomised parallel-group, superiority trial comparing the outcomes of (1) EA plus on-demand gastrocaine group and (2) waiting list to EA plus on-demand gastrocaine group...
March 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29590358/gene-expression-classifier-versus-targeted-next-generation-sequencing-in-the-management-of-indeterminate-thyroid-nodules
#7
Masha J Livhits, Eric J Kuo, Angela M Leung, Jianyu Rao, Mary Levin, Michael L Douek, Katrina R Beckett, Kyle A Zanocco, Dianne S Cheung, Yaroslav A Gofnung, Stephanie Smooke Praw, Michael W Yeh
Context: Molecular testing has reduced the need for diagnostic hemithyroidectomy for indeterminate thyroid nodules. No studies have directly compared molecular testing techniques. Objective: Compare diagnostic performance of Afirma Gene Expression Classifier (GEC) and ThyroSeq v2 next-generation sequencing assay. Design: Parallel randomized trial, monthly block randomization of patients with Bethesda III / IV cytology to GEC or ThyroSeq v2...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29540423/does-modifying-the-timing-of-meal-intake-improve-cardiovascular-risk-factors-protocol-of-an-australian-pilot-intervention-in-night-shift-workers-with-abdominal-obesity
#8
Maxine P Bonham, Gloria K W Leung, Rochelle Davis, Tracey L Sletten, Chiara Murgia, Morag J Young, Nina Eikelis, Elisabeth A Lambert, Catherine E Huggins
INTRODUCTION: Shift work is an independent risk factor for cardiovascular disease (CVD). Shift workers who are awake overnight and sleep during the day are misaligned with their body's endogenous circadian rhythm. Eating at night contributes to this increased risk of CVD by forcing the body to actively break down and process nutrients at night. This pilot study aims to determine whether altering meal timing overnight, in a shift working population, will impact favourably on modifiable risk factors for CVD (postprandial bplasma lipids and glucose concentration)...
March 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29531959/rationale-and-design-of-the-screening-of-pulmonary-hypertension-in-systemic-lupus-erythematosus-sophie-study
#9
Duo Huang, Yang-Yang Cheng, Pak-Hei Chan, Jojo Hai, Kai-Hang Yiu, Hung-Fat Tse, Ka-Lam Wong, Katherine Fan, Ying Wah Li, Woon-Leung Ng, Cheuk-Wan Yim, Cheuk-Hon John Wong, Lai-Shan Tam, Priscilla C H Wong, Chi-Yuen Wong, Chup-Hei Ho, Alexander M H Leung, Chi-Chiu Mok, Ho Lam, Chak-Sing Lau, Tommy Cheung, Carmen Ho, Sharon W Y Law, Esther W Chan, Li-Xue Yin, Wen-Sheng Yue, Toi Meng Mok, Mario Alberto Evora, Chung-Wah Siu
Current guideline-recommended screening for pulmonary hypertension in patients with systemic sclerosis has not been evaluated in systemic lupus erythematosus (SLE), which is disproportionately prevalent in Asians. This multicentre, cross-sectional screening study aims to study the prevalence of pulmonary hypertension among SLE patients using these guidelines, and identify independent predictors and develop a prediction model for pulmonary hypertension in SLE patients. SLE patients from participating centres will undergo an echocardiography- and biomarker-based pulmonary hypertension screening procedure as in the DETECT study...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29496055/three-dimensional-printing-of-patient-specific-surgical-plates-in-head-and-neck-reconstruction-a-prospective-pilot-study
#10
Wei-Fa Yang, Wing Shan Choi, Yiu Yan Leung, Justin Paul Curtin, Ruxu Du, Chun-Yu Zhang, Xian-Shuai Chen, Yu-Xiong Su
BACKGROUND: Surgical plates have been extensively used in head and neck reconstruction and conventional plates are mass-produced with universal configurations. To overcome disadvantages of conventional surgical plates, we have been exploring patient-specific surgical plates using the three-dimensional (3D) printing technology. We hypothesized that the application of 3D-printed patient-specific surgical plates in head and neck reconstruction is feasible, safe and precise. METHODS: We are conducting a prospective clinical trial to assess the feasibility, safety and accuracy of applying 3D-printed patient-specific surgical plates in head and neck reconstruction...
March 2018: Oral Oncology
https://www.readbyqxmd.com/read/29432521/final-validation-of-the-promise-molecular-classifier-for-endometrial-carcinoma-in-a-large-population-based-case-series
#11
S Kommoss, M K McConechy, F Kommoss, S Leung, A Bunz, J Magrill, H Britton, F Kommoss, F Grevenkamp, A Karnezis, W Yang, A Lum, B Krämer, F Taran, A Staebler, S Lax, S Y Brucker, D G Huntsman, C B Gilks, J N McAlpine, A Talhouk
Introduction: Based on The Cancer Genome Atlas, we previously developed and confirmed a pragmatic molecular classifier for endometrial cancers; ProMisE (Proactive Molecular Risk Classifier for Endometrial Cancer). ProMisE identifies four prognostically distinct molecular subtypes, and can be applied to diagnostic specimens (biopsy/curettings), enabling earlier informed decision-making. We have strictly adhered to the Institute of Medicine (IOM) guidelines for the development of genomic biomarkers, and herein present the final validation step of a locked-down classifier prior to clinical application...
February 7, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29426008/colchicine-lack-of-effectiveness-in-symptom-and-inflammation-modification-in-knee-osteoarthritis-colkoa-a-randomized-controlled-trial
#12
Y Y Leung, B Haaland, J L Huebner, S B S Wong, M Tjai, C Wang, B Chowbay, J Thumboo, B Chakraborty, M H Tan, V B Kraus
OBJECTIVES: Uric acid may activate an innate immune response in osteoarthritis (OA), contributing to disease pathology and progression. We evaluated the effectiveness of colchicine on pain and function in symptomatic knee OA (KOA) and the underlying mechanism of action. METHODS: Colchicine effectiveness in symptoms and inflammation modification in knee osteoarthritis (COLKOA) was a double-blind, placebo-controlled, randomized trial comparing 16 weeks of treatment with 0...
May 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29416567/involvement-of-gut-microbiome-in-human-health-and-disease-brief-overview-knowledge-gaps-and-research-opportunities
#13
REVIEW
Dachao Liang, Ross Ka-Kit Leung, Wenda Guan, William W Au
The commensal, symbiotic, and pathogenic microbial community which resides inside our body and on our skin (the human microbiome) can perturb host energy metabolism and immunity, and thus significantly influence development of a variety of human diseases. Therefore, the field has attracted unprecedented attention in the last decade. Although a large amount of data has been generated, there are still many unanswered questions and no universal agreements on how microbiome affects human health have been agreed upon...
2018: Gut Pathogens
https://www.readbyqxmd.com/read/29408866/oral-paracetamol-and-or-ibuprofen-for-treating-pain-after-soft-tissue-injuries-single-centre-double-blind-randomised-controlled-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Kevin K C Hung, Colin A Graham, Ronson S L Lo, Yuk Ki Leung, Ling Yan Leung, S Y Man, W K Woo, Giles N Cattermole, Timothy H Rainer
BACKGROUND: Soft tissue injuries commonly present to the emergency department (ED), often with acute pain. They cause significant suffering and morbidity if not adequately treated. Paracetamol and ibuprofen are commonly used analgesics, but it remains unknown if either one or the combination of both is superior for pain control. OBJECTIVES: To investigate the analgesic effect of paracetamol, ibuprofen and the combination of both in the treatment of soft tissue injury in an ED, and the side effect profile of these drugs...
2018: PloS One
https://www.readbyqxmd.com/read/29381966/hemolytic-anemia-in-alcoholic-liver-disease-zieve-syndrome-a-case-report-and-literature-review
#15
Miao-Xia Liu, Xiao-Yu Wen, Ying-Kit Leung, Yi-Jie Zheng, Mei-Shan Jin, Qing-Long Jin, Jun-Qi Niu
RATIONALE: Zieve syndrome, a rarely reported disease resulting from alcohol abuse, consists of a triad of symptoms: hemolytic anemia, cholestatic jaundice, and transient hyperlipidemia. It is largely under-recognized and under-reported, possibly because of unawareness of the condition by physicians. Here, we report a case of Zieve syndrome managed at the Jilin University First Bethune Hospital. PATIENT CONCERNS: A 30-year-old Chinese woman presented with a 4-month history of fatigue, yellowish discoloration of the eyes, and tea-colored urine...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29317635/publisher-correction-random-access-quantum-information-processors-using-multimode-circuit-quantum-electrodynamics
#16
R K Naik, N Leung, S Chakram, Peter Groszkowski, Y Lu, N Earnest, D C McKay, Jens Koch, D I Schuster
In the original version of this Article, the affiliation details for Peter Groszkowski and Jens Koch were incorrectly given as 'Department of Physics, University of Chicago, Chicago, IL, 60637, USA', instead of the correct 'Department of Physics and Astronomy, Northwestern University, Evanston, Illinois 60208, USA'. This has now been corrected in both the PDF and HTML versions of the Article.
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29299224/the-effectiveness-of-functional-electrical-stimulation-fes-in-on-off-mode-for-enhancing-the-cycling-performance-of-team-phoenix-at-2016-cybathlon
#17
Kenry Wc Leung, Raymond Ky Tong, Xiaojun Wang, Ginny Ty Lee, Peter Mk Pang, H W Wai, H C Leung
In this study we designed a Functional Electrical Stimulation (FES) trike for a female subject with spinal cord injury to exercise her lower limbs and improve her lower limb muscle condition for attending the 2016 Cybathlon FES bike competition. Our FES pilot was the only female participant, in the FES cycling competition and she rode for Team Phoenix from the Chinese University of Hong Kong. Due to the weakness of muscles in the lower limb of the subject, and due to scoliosis over her thoracolumbar aéra, the mechanical structure of the trike had to be tailor-made to ensure she sat on the bike in a safe and secure position...
December 5, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29239246/association-between-sonographically-measured-mesenteric-fat-thickness-and-brachial-artery-flow-mediated-dilation-in-chinese-young-male-adults
#18
Stanley Py Siu, Wilson Kc Leung, Polly Sc Wan, Eric Kh Liu, Christopher Wk Lai
Objective To investigate the potential correlation between sonographically measured mesenteric fat thickness (MFT) and brachial artery flow-mediated dilation (FMD) in a sample of healthy Chinese male young adults. Methods Healthy male participants were recruited from Hong Kong Polytechnic University for this prospective observational study. The physical activity readiness questionnaire and ultrasound measurements of carotid intima media thickness were used to screen for clinically healthy subjects. MFT and brachial artery FMD were measured by ultrasound, and body mass index (BMI) was recorded...
December 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29232166/revisiting-knowledge-attitudes-and-practice-kap-on-human-papillomavirus-hpv-vaccination-among-female-university-students-in-hong-kong
#19
Jonathan Tin Chi Leung, Chi-Kin Law
Despite cervical cancer can be preventable by HPV vaccination, little is known on its associated factors among young females in Hong Kong. This study aimed to investigate the present situation regarding the self-reported knowledge, attitudes and practice (KAP) of Human Papillomavirus (HPV) vaccination and to examine their associated factors among female university students in Hong Kong. 195 respondents were recruited to complete a self-administered questionnaire from two local universities through convenience sampling...
December 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29219888/computed-tomography-features-associated-with-the-eighth-edition-tnm-stage-classification-for-thymic-epithelial-tumors
#20
Sukhmani K Padda, Donato Terrone, Lu Tian, Amanda Khuong, Joel W Neal, Jonathan W Riess, Mark F Berry, Chuong D Hoang, Bryan M Burt, Ann N Leung, Erich J Schwartz, Joseph B Shrager, Heather A Wakelee
PURPOSE: The eighth edition of the TNM classification of malignant tumors for the first time includes an official staging system for thymic epithelial tumors (TETs) recognized by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC). Staging is critical for the management of TETs, and determining stage accurately from imaging has the potential to improve clinical outcomes. We examine preoperative computed tomography (CT) characteristics of TETs associated with AJCC/UICC pathologic TNM stage...
December 6, 2017: Journal of Thoracic Imaging
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