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https://www.readbyqxmd.com/read/28047670/su-f-p-20-predicting-waiting-times-in-radiation-oncology-using-machine-learning
#1
A Joseph, D Herrera, T Hijal, L Hendren, A Leung, J Wainberg, M Sawaf, M Gorshkov, R Maglieri, M Keshavarz, J Kildea
PURPOSE: Waiting times remain one of the most vexing patient satisfaction challenges facing healthcare. Waiting time uncertainty can cause patients, who are already sick or in pain, to worry about when they will receive the care they need. These waiting periods are often difficult for staff to predict and only rough estimates are typically provided based on personal experience. This level of uncertainty leaves most patients unable to plan their calendar, making the waiting experience uncomfortable, even painful...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28025771/early-experience-with-laparoscopic-frey-procedure-for-chronic-pancreatitis-a-case-series-and-review-of-literature
#2
Daniel J Kilburn, Adrian K H Chiow, Universe Leung, Mehan Siriwardhane, David J Cavallucci, Richard Bryant, Nicholas A O'Rourke
The Frey procedure has been demonstrated to be an effective surgical technique to treat patients with painful large duct chronic pancreatitis. More commonly reported as an open procedure, we report our experience with a minimally invasive approach to the Frey procedure. Four consecutive patients underwent a laparoscopic Frey procedure at our institution from January 2012 to July 2015. We herein report our technique and describe short- and medium-term outcomes. The median age was 40 years old. The median duration of pancreatic pain prior to surgery was 12 years...
December 26, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28009741/colorectal-cancer-liver-metastases-and-concurrent-extrahepatic-disease-treated-with-resection
#3
Universe Leung, Mithat Gönen, Peter J Allen, T Peter Kingham, Ronald P DeMatteo, William R Jarnagin, Michael I D'Angelica
OBJECTIVE: The aim of the study was to evaluate outcomes after resection of colorectal liver metastases (CRLM) and concurrent extrahepatic disease (EHD), and to define prognostic factors. BACKGROUND: There is increasing evidence to support resection of liver metastases and concurrent EHD in selected patients. Long-term survival data are lacking, and prognostic factors are not well defined. METHODS: Retrospective review of 219 patients was undertaken between January 1992 and December 2012, who underwent hepatectomy for CRLM and resection of synchronous EHD...
January 2017: Annals of Surgery
https://www.readbyqxmd.com/read/27993329/an-mrna-gene-expression-based-signature-to-identify-fgfr1-amplified-estrogen-receptor-positive-breast-tumors
#4
Jingqin Luo, Shuzhen Liu, Samuel Leung, Alejandro A Gru, Yu Tao, Jeremy Hoog, Julie Ho, Sherri R Davies, D Craig Allred, Andrea L Salavaggione, Jacqueline Snider, Elaine R Mardis, Torsten O Nielsen, Matthew J Ellis
Fibroblast growth factor receptor 1 (FGFR1) amplification drives poor prognosis and is an emerging therapeutic target. We sought to construct a multigene mRNA expression signature to efficiently identify FGFR1-amplified estrogen receptor-positive (ER(+)) breast tumors. Five independent breast tumor series were analyzed. Genes discriminative for FGFR1 amplification were screened transcriptome-wide by receiver operating characteristic analyses. The METABRIC series was leveraged to construct/evaluate four approaches to signature composition...
January 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27986182/episiotomy-technique-and-management-of-anal-sphincter-tears-a-survey-of-clinical-practice-and-education
#5
Rebecca Menzies, Marian Leung, Nirmala Chandrasekaran, Andrea Lausman, Michael Geary
OBJECTIVE: To ascertain current techniques of episiotomy used by obstetrics and gynaecology faculty members and residents in an academic department and to determine the current management strategies for third and fourth degree tears. METHOD: A 14-question anonymous online survey was circulated to all faculty members and residents in the University of Toronto Department of Obstetrics and Gynaecology between October 2015 and March 2016. Results were analyzed descriptively or with Fisher exact test...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27968905/the-effect-of-an-e-health-web-based-support-programme-on-psychological-outcomes-and-health-related-quality-of-life-among-chinese-patients-with-coronary-heart-disease-a-parallel-group-randomised-controlled-trial
#6
Eliza M L Wong, Sek Y Chair, Doris Y Leung, Janet W Sit, Aileen W Chan, Kai C Leung
BACKGROUND: Coronary heart disease is the leading global cause of death, and e-health web-based programmes are effective to support patients. However, fewstudieshave reported psychological outcomes and health related quality of life (HRQoL) in Chinese populations. This study aimed to investigate the effect of an e-health web-based support programme for patients with coronary heart disease on anxiety, depression, and HRQoL across six months. METHODS: This parallel-group, randomised controlled trial was conducted in two specialist clinics in Hong Kong, China...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968866/associations-between-body-mass-index-and-second-hand-smoke-exposure-and-stroke-recurrence-in-chinese-patients-in-xi-an-shantou-and-chongqing-a-multicentre-cross-sectional-survey
#7
Doris Y P Leung, Eliza M L Wong, Aileen W K Chan, Yong Zhao, Janet W H Sit
BACKGROUND: Recurrence of stroke is common and it affects quality of life, mobility, and mortality rates of stroke survivors. Previous studies have shown a paradoxical association between body mass index (BMI) and post-stroke mortality, and a dose-dependent association between second-hand smoke (SHS) exposure and risk of stroke. But the associations between BMI, SHS exposure, and stroke recurrence are unclear. We aimed to examine these associations in stroke survivors. METHODS: This cross-sectional survey was done in Xi'an, Shantou, and Chongqing...
October 2016: Lancet
https://www.readbyqxmd.com/read/27965196/sickle-cell-disease-an-international-survey-of-results-of-hla-identical-sibling-hematopoietic-stem-cell-transplantation
#8
Eliane Gluckman, Barbara Cappelli, Francoise Bernaudin, Myriam Labopin, Fernanda Volt, Jeanette Carreras, Belinda Pinto Simões, Alina Ferster, Sophie Dupont, Josu de la Fuente, Jean-Hugues Dalle, Marco Zecca, Mark C Walters, Lakshmanan Krishnamurti, Monica Bhatia, Kathryn Leung, Gregory Yanik, Joanne Kurtzberg, Nathalie Dhedin, Mathieu Kuentz, Gerard Michel, Jane Apperley, Patrick Lutz, Bénédicte Neven, Yves Bertrand, Jean Pierre Vannier, Mouhab Ayas, Marina Cavazzana, Susanne Matthes-Martin, Vanderson Rocha, Hanadi Elayoubi, Chantal Kenzey, Peter Bader, Franco Locatelli, Annalisa Ruggeri, Mary Eapen
Despite advances in supportive therapy to prevent complications of sickle cell disease (SCD), access to care is not universal. Hematopoietic cell transplantation is, to date, the only curative therapy for SCD, but its application is limited by availability of a suitable HLA-matched donor and lack of awareness of the benefits of transplant. Included in this study are 1000 recipients of HLA-identical sibling transplants performed between 1986 and 2013 and reported to the European Blood and Marrow Transplant, Eurocord and the Center for International Blood and Marrow Transplant Research...
December 13, 2016: Blood
https://www.readbyqxmd.com/read/27932412/universal-haplotype-based-noninvasive-prenatal-testing-for-single-gene-diseases
#9
Winnie W I Hui, Peiyong Jiang, Yu K Tong, Wing-Shan Lee, Yvonne K Y Cheng, Maria I New, Rezan A Kadir, K C Allen Chan, Tak Y Leung, Y M Dennis Lo, Rossa W K Chiu
BACKGROUND: Researchers have developed approaches for the noninvasive prenatal testing of single gene diseases. One approach that allows for the noninvasive assessment of both maternally and paternally inherited mutations involves the analysis of single nucleotide polymorphisms (SNPs) in maternal plasma DNA with reference to parental haplotype information. In the past, parental haplotypes were resolved by complex experimental methods or inferential approaches, such as through the analysis of DNA from other affected family members...
December 8, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27916206/how-many-oocytes-are-optimal-to%C3%A2-achieve-multiple-live-births-with%C3%A2-one-stimulation-cycle-the%C3%A2-one%C3%A2-and-done-approach
#10
Denis A Vaughan, Angela Leung, Nina Resetkova, Robin Ruthazer, Alan S Penzias, Denny Sakkas, Michael M Alper
OBJECTIVE: To study how many infertility patients would complete an average-sized family (achieve ≥2 live births) after a single, complete in vitro fertilization (IVF) cycle. DESIGN: A retrospective cohort study. SETTING: University-affiliated private infertility practice. PATIENT(S): Women undergoing IVF. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The outcome of 1 or ≥2 live births after a single retrieval cycle, followed by use of all embryos in subsequent frozen cycles in relation to oocyte number...
December 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27914853/monitoring-the-fitness-of-antiviral-resistant-influenza-strains-during-an-epidemic-a-mathematical-modelling-study
#11
Kathy Leung, Marc Lipsitch, Kwok Yung Yuen, Joseph T Wu
BACKGROUND: Antivirals (eg, oseltamivir) are important for mitigating influenza epidemics. In 2007, an oseltamivir-resistant influenza seasonal A H1N1 strain emerged and spread to global fixation within 1 year. This event showed that antiviral-resistant (AVR) strains can be intrinsically more transmissible than their contemporaneous antiviral-sensitive (AVS) counterpart. Surveillance of AVR fitness is therefore essential. Our objective was to develop a simple method for estimating AVR fitness from surveillance data...
November 30, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27687749/the-economic-and-social-value-of-an-image-exchange-network-a-case-for-the-cloud
#12
Ray Cody Mayo, Kathryn L Pearson, David E Avrin, Jessica W T Leung
As the health care environment continually changes, radiologists look to the ACR's Imaging 3.0(®) initiative to guide the search for value. By leveraging new technology, a cloud-based image exchange network could provide secure universal access to prior images, which were previously siloed, to facilitate accurate interpretation, improved outcomes, and reduced costs. The breast imaging department represents a viable starting point given the robust data supporting the benefit of access to prior imaging studies, existing infrastructure for image sharing, and the current workflow reliance on prior images...
January 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27682748/voiding-function-after-midurethral-slings-with-and-without-local-anesthetic-randomized-controlled-trial
#13
Omar Felipe Dueñas-Garcia, Danielle Patterson, Maria De la Luz Nieto, Katherine Leung, Michael Kevin Flynn
OBJECTIVES: This study aimed to compare the effect of periurethral infiltration of bupivacaine versus normal saline on postoperative voiding function and pain in patients undergoing retropubic midurethral sling METHODS: A randomized double-blind placebo-controlled study was performed at the University of Massachusetts from March 2012 to June 2015. Ninety patients were randomized to receive 0.5% bupivacaine with epinephrine or normal saline with epinephrine solution for periurethral hydrodissection...
January 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27673384/evaluating-the-performance-of-the-pediatric-acute-lung-injury-consensus-conference-definition-of-acute-respiratory-distress-syndrome
#14
Kaushik Parvathaneni, Sanjay Belani, Dennis Leung, Christopher J L Newth, Robinder G Khemani
OBJECTIVE: The Pediatric Acute Lung Injury Consensus Conference has developed a pediatric-specific definition of acute respiratory distress syndrome, which is a significant departure from both the Berlin and American European Consensus Conference definitions. We sought to test the external validity and potential impact of the Pediatric Acute Lung Injury Consensus Conference definition by comparing the number of cases of acute respiratory distress syndrome and mortality rates among children admitted to a multidisciplinary PICU when classified by Pediatric Acute Lung Injury Consensus Conference, Berlin, and American European Consensus Conference criteria...
September 23, 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27595446/rotavirus-vaccine-effectiveness-in-hong-kong-children
#15
Karene Hoi Ting Yeung, Jacqueline E Tate, Ching Ching Chan, Martin C W Chan, Paul K S Chan, Kin Hung Poon, Sylvia Luen Yee Siu, Genevieve Po Gee Fung, Kwok Leung Ng, Iris Mei Ching Chan, Pui Tak Yu, Chi Hang Ng, Yu Lung Lau, E Anthony S Nelson
BACKGROUND: Rotavirus is a common infectious cause of childhood hospitalisation in Hong Kong. Rotavirus vaccines have been used in the private sector since licensure in 2006 but have not been incorporated in the government's universal Childhood Immunisation Programme. This study aimed to evaluate rotavirus vaccine effectiveness against hospitalisation. METHODS: This case-control study was conducted in the 2014/2015 rotavirus season in six public hospitals. Hospitalised acute gastroenteritis patients meeting inclusion criteria were recruited and copies of their immunisation records were collected...
September 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27578294/pragmatic-cluster-randomised-trial-of-a-free-telephone-based-health-coaching-program-to-support-women-in-managing-weight-gain-during-pregnancy-the-get-healthy-in-pregnancy-trial
#16
Vanessa Clements, Kit Leung, Santosh Khanal, Jane Raymond, Michelle Maxwell, Chris Rissel
BACKGROUND: Excessive gestational weight gain can result in poor maternal and child health outcomes. Estimates from single studies indicate the prevalence of excessive gestational weight gain in Australia could lie between 38 and 67 %. The risk of excessive weight gain can be reduced through healthy eating and exercise. We describe the rationale and methods of the Get Healthy in Pregnancy Service, a trial service which aims to support women in achieving appropriate gestational weight gain through an existing telephone-based health coaching service...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27507855/adult-playfulness-humor-styles-and-subjective-happiness
#17
Xiao D Yue, Chun-Lok Leung, Neelam A Hiranandani
Playfulness has been referred to as a disposition that involves reframing a situation to amuse others and to make the situation more stimulating and enjoyable. It may serve to shift one's perspective when dealing with environmental threats. Despite all the benefits of playfulness towards psychological well-being, it remains a largely understudied subject in psychology, particularly in Chinese societies. Hence, this study examined the association between adult playfulness, humor styles, and subjective happiness among a sample of 166 university students in Hong Kong and 159 students in Guangzhou, who completed a self-administered questionnaire, including the Short Measure for Adult Playfulness, the Chinese Humor Styles Questionnaire, and the Subjective Happiness Scale...
December 2016: Psychological Reports
https://www.readbyqxmd.com/read/27496229/semi-individualised-chinese-medicine-treatment-as-an-adjuvant-management-for-diabetic-nephropathy-a-pilot-add-on-randomised-controlled-multicentre-open-label-pragmatic-clinical-trial
#18
Kam Wa Chan, Tai Pang Ip, Alfred Siu Kei Kwong, Sing Leung Lui, Gary Chi Wang Chan, Benjamin John Cowling, Wai Han Yiu, Dickson Wai Leong Wong, Yang Liu, Yibin Feng, Kathryn Choon Beng Tan, Loretta Yuk Yee Chan, Joseph Chi Kam Leung, Kar Neng Lai, Sydney Chi Wai Tang
INTRODUCTION: Diabetes mellitus and diabetic nephropathy (DN) are prevalent and costly to manage. DN is the leading cause of end-stage kidney disease. Conventional therapy blocking the renin-angiotensin system has only achieved limited effect in preserving renal function. Recent observational data show that the use of Chinese medicine (CM), a major form of traditional medicine used extensively in Asia, could reduce the risk of end-stage kidney disease. However, existing clinical practice guidelines are weakly evidence-based and the effect of CM remains unclear...
August 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27494401/identifying-the-dominant-personality-profiles-in-medical-students-implications-for-their-well-being-and-resilience
#19
Diann S Eley, Janni Leung, Barry A Hong, Kevin M Cloninger, C Robert Cloninger
PURPOSE: There is a high prevalence of stress, depression, and burn-out in medical students. Medical students differ widely in personality traits, self-perceptions, and values that may have an impact on their well-being. This study aimed to investigate variability in their personality profiles in relation to their potential for well-being and resilience. METHOD: Participants were 808 medical students from The University of Queensland. An online questionnaire collected socio-demographics and the Temperament and Character Inventory to assess personality traits...
2016: PloS One
https://www.readbyqxmd.com/read/27456342/motivating-smokers-at-outdoor-public-smoking-hotspots-to-have-a-quit-attempt-with-a-nicotine-replacement-therapy-sample-study-protocol-for-a-randomized-controlled-trial
#20
Yee Tak Derek Cheung, Jessica Pui Kei Leung, Chelsia Ka Ching Cheung, William Ho Cheung Li, Man Ping Wang, Tai Hing Lam
BACKGROUND: About half of the daily smokers in Hong Kong have never tried and have no intention to quit smoking. More than one-third (37.9 %) of daily smokers have attempted to quit but failed. Nicotine replacement therapy (NRT) is a safe and effective pharmacotherapy to increase abstinence by reducing withdrawal symptoms during the early stage of smoking abstinence. However, the prevalence of NRT use in Hong Kong is lower than in most developed countries. The proposed study aims to assess the effectiveness of providing free NRT samples to smokers on increasing quit attempts and the quit rate...
July 26, 2016: Trials
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