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Ray Cody Mayo, Kathryn L Pearson, David E Avrin, Jessica W T Leung
As the health care environment continually changes, radiologists look to the ACR's Imaging 3.0(®) initiative to guide the search for value. By leveraging new technology, a cloud-based image exchange network could provide secure universal access to prior images, which were previously siloed, to facilitate accurate interpretation, improved outcomes, and reduced costs. The breast imaging department represents a viable starting point given the robust data supporting the benefit of access to prior imaging studies, existing infrastructure for image sharing, and the current workflow reliance on prior images...
September 24, 2016: Journal of the American College of Radiology: JACR
Omar Felipe Dueñas-Garcia, Danielle Patterson, Maria De la Luz Nieto, Katherine Leung, Michael Kevin Flynn
OBJECTIVES: This study aimed to compare the effect of periurethral infiltration of bupivacaine versus normal saline on postoperative voiding function and pain in patients undergoing retropubic midurethral sling METHODS: A randomized double-blind placebo-controlled study was performed at the University of Massachusetts from March 2012 to June 2015. Ninety patients were randomized to receive 0.5% bupivacaine with epinephrine or normal saline with epinephrine solution for periurethral hydrodissection...
September 26, 2016: Female Pelvic Medicine & Reconstructive Surgery
Kaushik Parvathaneni, Sanjay Belani, Dennis Leung, Christopher J L Newth, Robinder G Khemani
OBJECTIVE: The Pediatric Acute Lung Injury Consensus Conference has developed a pediatric-specific definition of acute respiratory distress syndrome, which is a significant departure from both the Berlin and American European Consensus Conference definitions. We sought to test the external validity and potential impact of the Pediatric Acute Lung Injury Consensus Conference definition by comparing the number of cases of acute respiratory distress syndrome and mortality rates among children admitted to a multidisciplinary PICU when classified by Pediatric Acute Lung Injury Consensus Conference, Berlin, and American European Consensus Conference criteria...
September 23, 2016: Pediatric Critical Care Medicine
Karene Hoi Ting Yeung, Jacqueline E Tate, Ching Ching Chan, Martin C W Chan, Paul K S Chan, Kin Hung Poon, Sylvia Luen Yee Siu, Genevieve Po Gee Fung, Kwok Leung Ng, Iris Mei Ching Chan, Pui Tak Yu, Chi Hang Ng, Yu Lung Lau, E Anthony S Nelson
BACKGROUND: Rotavirus is a common infectious cause of childhood hospitalisation in Hong Kong. Rotavirus vaccines have been used in the private sector since licensure in 2006 but have not been incorporated in the government's universal Childhood Immunisation Programme. This study aimed to evaluate rotavirus vaccine effectiveness against hospitalisation. METHODS: This case-control study was conducted in the 2014/2015 rotavirus season in six public hospitals. Hospitalised acute gastroenteritis patients meeting inclusion criteria were recruited and copies of their immunisation records were collected...
September 22, 2016: Vaccine
Vanessa Clements, Kit Leung, Santosh Khanal, Jane Raymond, Michelle Maxwell, Chris Rissel
BACKGROUND: Excessive gestational weight gain can result in poor maternal and child health outcomes. Estimates from single studies indicate the prevalence of excessive gestational weight gain in Australia could lie between 38 and 67 %. The risk of excessive weight gain can be reduced through healthy eating and exercise. We describe the rationale and methods of the Get Healthy in Pregnancy Service, a trial service which aims to support women in achieving appropriate gestational weight gain through an existing telephone-based health coaching service...
2016: BMC Health Services Research
Xiao D Yue, Chun-Lok Leung, Neelam A Hiranandani
Playfulness has been referred to as a disposition that involves reframing a situation to amuse others and to make the situation more stimulating and enjoyable. It may serve to shift one's perspective when dealing with environmental threats. Despite all the benefits of playfulness towards psychological well-being, it remains a largely understudied subject in psychology, particularly in Chinese societies. Hence, this study examined the association between adult playfulness, humor styles, and subjective happiness among a sample of 166 university students in Hong Kong and 159 students in Guangzhou, who completed a self-administered questionnaire, including the Short Measure for Adult Playfulness, the Chinese Humor Styles Questionnaire, and the Subjective Happiness Scale...
August 9, 2016: Psychological Reports
Kam Wa Chan, Tai Pang Ip, Alfred Siu Kei Kwong, Sing Leung Lui, Gary Chi Wang Chan, Benjamin John Cowling, Wai Han Yiu, Dickson Wai Leong Wong, Yang Liu, Yibin Feng, Kathryn Choon Beng Tan, Loretta Yuk Yee Chan, Joseph Chi Kam Leung, Kar Neng Lai, Sydney Chi Wai Tang
INTRODUCTION: Diabetes mellitus and diabetic nephropathy (DN) are prevalent and costly to manage. DN is the leading cause of end-stage kidney disease. Conventional therapy blocking the renin-angiotensin system has only achieved limited effect in preserving renal function. Recent observational data show that the use of Chinese medicine (CM), a major form of traditional medicine used extensively in Asia, could reduce the risk of end-stage kidney disease. However, existing clinical practice guidelines are weakly evidence-based and the effect of CM remains unclear...
2016: BMJ Open
Diann S Eley, Janni Leung, Barry A Hong, Kevin M Cloninger, C Robert Cloninger
PURPOSE: There is a high prevalence of stress, depression, and burn-out in medical students. Medical students differ widely in personality traits, self-perceptions, and values that may have an impact on their well-being. This study aimed to investigate variability in their personality profiles in relation to their potential for well-being and resilience. METHOD: Participants were 808 medical students from The University of Queensland. An online questionnaire collected socio-demographics and the Temperament and Character Inventory to assess personality traits...
2016: PloS One
Yee Tak Derek Cheung, Jessica Pui Kei Leung, Chelsia Ka Ching Cheung, William Ho Cheung Li, Man Ping Wang, Tai Hing Lam
BACKGROUND: About half of the daily smokers in Hong Kong have never tried and have no intention to quit smoking. More than one-third (37.9 %) of daily smokers have attempted to quit but failed. Nicotine replacement therapy (NRT) is a safe and effective pharmacotherapy to increase abstinence by reducing withdrawal symptoms during the early stage of smoking abstinence. However, the prevalence of NRT use in Hong Kong is lower than in most developed countries. The proposed study aims to assess the effectiveness of providing free NRT samples to smokers on increasing quit attempts and the quit rate...
2016: Trials
M Gordon Joyce, Adam K Wheatley, Paul V Thomas, Gwo-Yu Chuang, Cinque Soto, Robert T Bailer, Aliaksandr Druz, Ivelin S Georgiev, Rebecca A Gillespie, Masaru Kanekiyo, Wing-Pui Kong, Kwanyee Leung, Sandeep N Narpala, Madhu S Prabhakaran, Eun Sung Yang, Baoshan Zhang, Yi Zhang, Mangaiarkarasi Asokan, Jeffrey C Boyington, Tatsiana Bylund, Sam Darko, Christopher R Lees, Amy Ransier, Chen-Hsiang Shen, Lingshu Wang, James R Whittle, Xueling Wu, Hadi M Yassine, Celia Santos, Yumiko Matsuoka, Yaroslav Tsybovsky, Ulrich Baxa, James C Mullikin, Kanta Subbarao, Daniel C Douek, Barney S Graham, Richard A Koup, Julie E Ledgerwood, Mario Roederer, Lawrence Shapiro, Peter D Kwong, John R Mascola, Adrian B McDermott
Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing diverse subtypes of group 1 and group 2 influenza A viruses. Co-crystal structures with hemagglutinin revealed that each class utilized characteristic germline genes and convergent sequence motifs to recognize overlapping epitopes in the hemagglutinin stem...
July 28, 2016: Cell
Yi Man Wah, Tak Yeung Leung, Yvonne Kwun Yue Cheng, Daljit Singh Sahota
OBJECTIVE: The aim was to determine the institutional procedure-related fetal loss rate after chorionic villus sampling (CVS) and the factors which may identify pregnancies at increased risk of having a procedure-related loss. MATERIALS AND METHODS: Pregnancy outcomes were retrieved of all women having a singleton pregnancy and undergoing a CVS procedure between 2004 and 2013 at a university hospital in Hong Kong. The incidence of procedure-related fetal loss due to unintended miscarriages adjusted for the background loss incidence of miscarriages was determined...
July 12, 2016: Fetal Diagnosis and Therapy
T H Rainer, Y K Leung, A Lee, P Y Chan, N M Cheng, J K Wong, B P Yan, A T Ahuja, C A Graham
BACKGROUND: Chest pain patients commonly present to emergency departments (ED), and require either hospital admission and/or lengthy diagnostic protocols to rule-out myocardial infarction. We aimed to identify the best combination of add-on tests to high-sensitivity cardiac troponin (hs-cTnT) for predicting 30-day major adverse cardiac events (MACE) in adult chest pain patients presenting to an ED with suspected acute coronary syndrome. METHODS: This prospective observational study was conducted in the ED of a tertiary university hospital in Hong Kong, recruiting adult patients with chest pain of less than 24h duration, suspected with acute coronary syndrome (ACS), and had no history of coronary artery bypass grafting or stent insertion...
October 1, 2016: International Journal of Cardiology
Ruzena Tkacova, Darlene L Y Dai, Judith M Vonk, Janice M Leung, Pieter S Hiemstra, Maarten van den Berge, Lisette Kunz, Zsuzsanna Hollander, Donald Tashkin, Robert Wise, John Connett, Raymond Ng, Bruce McManus, S F Paul Man, Dirkje S Postma, Don D Sin
BACKGROUND: The impact of airway hyperreactivity (AHR) on respiratory mortality and systemic inflammation among patients with chronic obstructive pulmonary disease (COPD) is largely unknown. We used data from 2 large studies to determine the relationship between AHR and FEV1 decline, respiratory mortality, and systemic inflammation. OBJECTIVES: We sought to determine the relationship of AHR with FEV1 decline, respiratory mortality, and systemic inflammatory burden in patients with COPD in the Lung Health Study (LHS) and the Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) study...
May 24, 2016: Journal of Allergy and Clinical Immunology
Don D Sin, Marc Miravitlles, David M Mannino, Joan B Soriano, David Price, Bartolome R Celli, Janice M Leung, Yasutaka Nakano, Hye Yun Park, Peter A Wark, Michael E Wechsler
Patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) have been largely excluded from pivotal therapeutic trials and, as a result, its treatment remains poorly defined and lacking firm evidence. To date, there is no universally accepted definition of ACOS, which has made it difficult to understand its epidemiology or pathophysiology. Despite many uncertainties, there is emerging agreement that some of the key features of ACOS include persistent airflow limitation in symptomatic individuals 40 years of age and older, a well-documented history of asthma in childhood or early adulthood and a significant exposure history to cigarette or biomass smoke...
September 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Veronica Ka Wai Lai, Anna Lee, Patricia Leung, Chun Hung Chiu, Ka Man Ho, Charles David Gomersall, Malcolm John Underwood, Gavin Matthew Joynt
INTRODUCTION: Patients and their families are understandably anxious about the risk of complications and unfamiliar experiences following cardiac surgery. Providing information about postoperative care in the intensive care unit (ICU) to patients and families may lead to lower anxiety levels, and increased satisfaction with healthcare. The objectives of this study are to evaluate the effectiveness of preoperative patient education provided for patients undergoing elective cardiac surgery...
2016: BMJ Open
C-Y Yu, H-Y Ou, C-C Weng, T-L Huang, T-Y Chen, L Leung-Chit, H-W Hsu, C-L Chen, Y-F Cheng
BACKGROUND: The majority of hepatocellular carcinoma (HCC) patients is diagnosed in late stages and therefore becomes ineligible for potentially curative treatment such as resection or liver transplantation. Transarterial chemoembolization (TACE) with drug-eluting beads (DC beads, Biocompatibles, Farnham, United Kingdom) has been proven with less side effects and better efficacy than conventional TACE, especially among patients with poor liver function. PURPOSE: The aim of this study is to evaluate outcomes of HCC patients who received TACE with DC beads, which resulted to eligibility for liver transplantation...
May 2016: Transplantation Proceedings
T S Wildes, A C Winter, H R Maybrier, A M Mickle, E J Lenze, S Stark, N Lin, S K Inouye, E M Schmitt, S L McKinnon, M R Muench, M R Murphy, R T Upadhyayula, B A Fritz, K E Escallier, G P Apakama, D A Emmert, T J Graetz, T W Stevens, B J Palanca, R L Hueneke, S Melby, B Torres, J Leung, E Jacobsohn, M S Avidan
INTRODUCTION: Postoperative delirium, arbitrarily defined as occurring within 5 days of surgery, affects up to 50% of patients older than 60 after a major operation. This geriatric syndrome is associated with longer intensive care unit and hospital stay, readmission, persistent cognitive deterioration and mortality. No effective preventive methods have been identified, but preliminary evidence suggests that EEG monitoring during general anaesthesia, by facilitating reduced anaesthetic exposure and EEG suppression, might decrease incident postoperative delirium...
2016: BMJ Open
Nathan Churchill, Michael Hutchison, Doug Richards, General Leung, Simon Graham, Tom A Schweizer
There is growing concern about the potential long-term consequences of sport concussion for young, currently active athletes. However, there remains limited information about brain abnormalities associated with a history of concussion and how they relate to clinical factors. In this study, advanced Magnetic Resonance Imaging (MRI) was used to comprehensively describe abnormalities in brain structure and function associated with a history of sport concussion. 43 athletes (21 male, 22 female) were recruited from inter-university teams at the beginning of the season, including 21 with a history of concussion and 22 without prior concussion; both groups also contained a balanced sample of contact and non-contact sports...
June 1, 2016: Journal of Neurotrauma
Yongxian Yuan, Huaiqian Xu, Ross Ka-Kit Leung
BACKGROUND: Previous studies compared running cost, time and other performance measures of popular sequencing platforms. However, comprehensive assessment of library construction and analysis protocols for Proton sequencing platform remains unexplored. Unlike Illumina sequencing platforms, Proton reads are heterogeneous in length and quality. When sequencing data from different platforms are combined, this can result in reads with various read length. Whether the performance of the commonly used software for handling such kind of data is satisfactory is unknown...
2016: BMC Genomics
Jun Huang, Xing-Xing Fan, Jiaxi He, Hui Pan, Run-Ze Li, Liyan Huang, Zebo Jiang, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung, Jian-Xing He
The discovery of Warburg effect opens a new era in anti-cancer therapy. Aerobic glycolysis is regarded as a hallmark of cancer cells and increasing literatures indicates that metabolic changes are critical for the maintenance and progression of cancer cells. Besides aerobic glycolysis, increased fatty acid synthesis is also required for the rapid growth of cancer cells, and is considered as one of the most typical metabolic symbols of cancer either. Thus, targeting fatty acid metabolism may provide a potential avenue for the diagnosis and therapeutic treatment of cancer...
May 19, 2016: Oncotarget
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