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https://www.readbyqxmd.com/read/28444974/school-based-surveillance-for-influenza-vaccine-effectiveness-during-2014-15-seasons-in-hong-kong
#1
Ting F Leung, Renee W Y Chan, Angela Kwok, Wendy C S Ho, Mars K P Tao, Kam L Hon, Frankie W T Cheng, Albert M Li, Paul K S Chan
BACKGROUND: Influenza imposes substantial healthcare burden in children, which can be prevented by vaccination. Influenza vaccination coverage varies widely among childhood populations worldwide, which has significant impact on herd immunity and usefulness of influenza vaccine. However, there is limited real-life data on influenza vaccine effectiveness (VE) in children. OBJECTIVE: This prospective study aimed to investigate clinical spectrum of childhood influenza and VE in preventing influenza in Hong Kong children...
April 26, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28444106/the-association-of-air-pollution-with-pubertal-development-evidence-from-hong-kong-s-children-of-1997-birth-cohort
#2
Jian V Huang, Gabriel M Leung, C Mary Schooling
Many pollutants are endocrine disruptors with impacts on reproduction and health in animals, but evidence in humans, of which sex-specific effects on pubertal development may be an indicator, is less clear. We examined the association of air pollution in utero and during early life with pubertal development in Hong Kong, China, an area with a high level of air pollution compared with other similarly developed cities. We assessed sex-specific associations of particulate matter less than or equal to 10 μm in diameter (PM10), nitric oxide, sulfur dioxide, and nitrogen dioxide in different growth phases with clinically assessed pubertal stage at approximately age 11 years (as indicated by Tanner stage) in a large population-representative birth cohort, the "Children of 1997...
April 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28443069/long-term-enrichment-of-stress-tolerant-cellulolytic-soil-populations-following-timber-harvesting-evidenced-by-multi-omic-stable-isotope-probing
#3
Roland C Wilhelm, Erick Cardenas, Hilary Leung, András Szeitz, Lionel D Jensen, William W Mohn
Soil management is vital for maintaining the productivity of commercial forests, yet the long-term impact of timber harvesting on soil microbial communities remains largely a matter of conjecture. Decomposition of plant biomass, comprised mainly of lignocellulose, has a broad impact on nutrient cycling, microbial activity and physicochemical characteristics of soil. At "Long-term Soil Productivity Study" sites in California dominated by Ponderosa pine, we tested whether clear-cut timber harvesting, accompanied by varying degrees of organic matter (OM) removal, affected the activity and structure of the cellulose-degrading microbial populations 16 years after harvesting...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28443025/honokiol-induces-apoptosis-g1-arrest-and-autophagy-in-kras-mutant-lung-cancer-cells
#4
Lian-Xiang Luo, Ying Li, Zhong-Qiu Liu, Xing-Xing Fan, Fu-Gang Duan, Run-Ze Li, Xiao-Jun Yao, Elaine Lai-Han Leung, Liang Liu
Aberrant signaling transduction induced by mutant KRAS proteins occurs in 20∼30% of non-small cell lung cancer (NSCLC), however, a direct and effective pharmacological inhibitor targeting KRAS has not yet reached the clinic to date. Honokiol, a small molecular polyphenol natural biophenolic compound derived from the bark of magnolia trees, exerts anticancer activity, however, its mechanism remains unknown. In this study, we sought to investigate the in vitro effects of honokiol on NSCLC cell lines harboring KRAS mutations...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28442911/are-psychiatric-comorbidities-and-associated-cognitive-functions-related-to-treatment-response-to-methylphenidate-in-boys-with-attention-deficit-hyperactivity-disorder
#5
Mandy H Chan, Patrick Wl Leung, Ting-Pong Ho, Se-Fong Hung, Chi-Chiu Lee, Chun-Pan Tang, Ka-Chai Cheung, Fung-Yee Ching, Fefe Hk Chan, Lu-Hua Chen, Merce Garcia-Barcelo, Pak-Chung Sham
BACKGROUND: Methylphenidate (MPH) has been found to be an effective medication for attention-deficit/hyperactivity disorder (ADHD). However, there are neither consistent nor sufficient findings on whether psychiatric comorbidities and associated cognitive functions of ADHD are related to treatment response to MPH in ADHD children. OBJECTIVES: This study investigated whether psychiatric comorbidities, IQ, and neurocognitive deficits are related to treatment response to MPH in ADHD children...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28442714/mitigating-herding-in-hierarchical-crowdsourcing-networks
#6
Han Yu, Chunyan Miao, Cyril Leung, Yiqiang Chen, Simon Fauvel, Victor R Lesser, Qiang Yang
Hierarchical crowdsourcing networks (HCNs) provide a useful mechanism for social mobilization. However, spontaneous evolution of the complex resource allocation dynamics can lead to undesirable herding behaviours in which a small group of reputable workers are overloaded while leaving other workers idle. Existing herding control mechanisms designed for typical crowdsourcing systems are not effective in HCNs. In order to bridge this gap, we investigate the herding dynamics in HCNs and propose a Lyapunov optimization based decision support approach - the Reputation-aware Task Sub-delegation approach with dynamic worker effort Pricing (RTS-P) - with objective functions aiming to achieve superlinear time-averaged collective productivity in an HCN...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28442470/late-outcomes-in-children-with-langerhans-cell-histiocytosis
#7
Tin Wai Chow, Wing Kwan Leung, Frankie Wai Tsoi Cheng, Shekhar Medhukar Kumta, Winnie Chiu Wing Chu, Vincent Lee, Matthew Ming Kong Shing, Chi Kong Li
INTRODUCTION: Langerhans cell histiocytosis (LCH) is a rare disease with diverse clinical courses. Despite improvement in survival outcomes in the recent decades, sequelae of the disease remain a concern. This study aimed to provide information on the long-term outcomes in patients with LCH, particularly on the sequelae and any associated factors. METHOD: Medical records of patients with diagnosis of LCH and being managed in our centre were retrospectively reviewed...
April 25, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28442458/circulating-micrornas-in-delayed-cerebral-infarction-after-aneurysmal-subarachnoid-hemorrhage
#8
Gang Lu, Man Sze Wong, Mark Zhi Qiang Xiong, Chi Kwan Leung, Xian Wei Su, Jing Ye Zhou, Wai Sang Poon, Vera Zhi Yuan Zheng, Wai Yee Chan, George Kwok Chu Wong
BACKGROUND: Delayed cerebral infarction (DCI) is a major cause of morbidities after aneurysmal subarachnoid hemorrhage (SAH) and typically starts at day 4 to 7 after initial hemorrhage. MicroRNAs (miRNAs) play an important role in posttranscriptional gene expression control, and distinctive patterns of circulating miRNA changes have been identified for some diseases. We aimed to investigate miRNAs that characterize SAH patients with DCI compared with those without DCI. METHODS AND RESULTS: Circulating miRNAs were collected on day 7 after SAH in healthy, SAH-free controls (n=20), SAH patients with DCI (n=20), and SAH patients without DCI (n=20)...
April 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28442202/macrobenthic-communities-in-hong-kong-waters-comparison-between-2001-and-2012-and-potential-link-to-pollution-control
#9
Zhi Wang, Kenneth M Y Leung, Xinzheng Li, Tong Zhang, Jian-Wen Qiu
Macrobenthic communities in 2001 and 2012 were compared across the marine environment of Hong Kong based on sediment grab samples collected from 28 stations. CLUSTER analysis showed in both surveys that the stations could be divided into four groups at 20% faunal similarity. However, there were notable changes in the macrobenthic community structure between 2001 and 2012 in three focal areas of pollution control (i.e., Victoria Harbour, Deep Bay and Tolo Harbour). The potential link between macrobenthos and pollution abatement measures, and the contributions of environmental conditions to the differential responsiveness of macrobenthos were explored...
April 23, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28441440/correction-relationships-between-mucosal-antibodies-non-typeable-haemophilus-influenzae-nthi-infection-and-airway-inflammation-in-copd
#10
Karl J Staples, Stephen Taylor, Steve Thomas, Stephanie Leung, Karen Cox, Thierry G Pascal, Kristoffer Ostridge, Lindsay Welch, Andrew C Tuck, Stuart C Clarke, Andrew Gorringe, Tom M A Wilkinson
[This corrects the article DOI: 10.1371/journal.pone.0167250.].
2017: PloS One
https://www.readbyqxmd.com/read/28441251/prognostic-role-of-histological-tumor-regression-in-patients-receiving-neoadjuvant-chemotherapy-for-high-grade-serous-tubo-ovarian-carcinoma
#11
Edwina Coghlan, Tarek M Meniawy, Aime Munro, Max Bulsara, Colin Jr Stewart, Adeline Tan, M H Eleanor Koay, Daniel MaGee, Jim Codde, Jason Tan, Stuart G Salfinger, Ganendra R Mohan, Yee Leung, Cassandra B Nichols, Paul A Cohen
OBJECTIVE: Our objective was to validate the prognostic role of the chemotherapy response score (CRS), which has been proposed for measuring tumor response to neoadjuvant chemotherapy in patients with high-grade serous tubo-ovarian carcinoma, in predicting progression-free survival (PFS) and overall survival (OS). METHODS: A retrospective cohort study was conducted of patients with advanced high-grade serous tubo-ovarian carcinoma diagnosed between January 1, 2010, and December 31, 2014, and treated with neoadjuvant chemotherapy...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28441105/transcriptomic-dissection-of-the-horizontally-acquired-response-regulator-esrb-reveals-its-global-regulatory-roles-in-the-physiological-adaptation-and-activation-of-t3ss-and-the-cognate-effector-repertoire-in-edwardsiella-piscicida-during-infection-towards
#12
Yang Liu, Luyao Zhao, Minjun Yang, Kaiyu Yin, Xiaohui Zhou, Ka Yin Leung, Qin Liu, Yuanxing Zhang, Qiyao Wang
Edwardsiella piscicida is the leading pathogen threatening worldwide aquaculture industries. The two-component system (TCS) EsrA-EsrB is essential for the pathogenesis of this bacterium. However, little is known about the regulon and regulatory mechanism of EsrA-EsrB or about the factors that mediate the interaction of TCS with bacterial hosts. Here, our RNA-seq analysis indicated that EsrB strongly induces type III and type VI secretion systems (T3/T6SS) expression and that it modulates the expression of both physiology- and virulence-associated genes in E...
April 25, 2017: Virulence
https://www.readbyqxmd.com/read/28441104/gestalt-intervention-groups-for-anxious-parents-in-hong-kong-a-quasi-experimental-design
#13
Grace Suk Man Leung, Su Hean Khor
This study examined the impact of gestalt intervention groups for anxious Chinese parents in Hong Kong. A non-randomized control group pre-test/post-test design was adopted. A total of 156 parents participated in the project. After 4 weeks of treatment, the intervention group participants had lower anxiety levels, less avoidance of inner experiences, and more kindness towards oneself and mindfulness when compared to control group participants. However, the dimension of self-judgment remained unchanged. The adaptation of gestalt intervention to suit the Chinese culture was discussed...
April 25, 2017: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/28441088/video-enabled-cue-exposure-based-intervention-improves-postdischarge-drinking-outcomes-among-alcohol-dependent-men-a-prospective-study-at-a-government-addiction-treatment-setting-in-india
#14
Prasanthi Nattala, Pratima Murthy, Kit Sang Leung, Sreevani Rentala, Jayashree Ramakrishna
Returning to alcohol use following inpatient treatment occurs due to various real life cues/triggers. It is a challenge to demonstrate to patients how to deal with these triggers during inpatient treatment. Aims of the current study were (a) to evaluate the effectiveness of video-enabled cue-exposure-based intervention (VE-CEI) in influencing treatment outcomes in alcohol dependence, (b) to identify postdischarge predictors of intervention failure (returning to ≥50% of baseline alcohol consumption quantity/day)...
April 25, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28439924/prevalence-and-predictors-of-thyroid-functional-abnormalities-in-newly-diagnosed-al-amyloidosis
#15
E Muchtar, D S Dean, A Dispenzieri, D Dingli, F K Buadi, M Q Lacy, S R Hayman, P Kapoor, N Leung, S Russell, J A Lust, Yi Lin, R Warsame, W Gonsalves, T V Kourelis, R S Go, R Chakraborty, S Zeldenrust, R A Kyle, S Vincent Rajkumar, S K Kumar, M A Gertz
BACKGROUND: Data on the effect of systemic immunoglobulin light chain amyloidosis (AL amyloidosis) on thyroid function are limited. OBJECTIVE: To assess the prevalence of hypothyroidism in AL amyloidosis patients and determine its predictors. METHODS: 1142 newly diagnosed AL amyloidosis patients were grouped based on the thyroid-stimulating hormone (TSH) measurement at diagnosis: hypothyroid group (TSH above upper normal reference; >5 mIU L(-1) ; n = 217, 19% of study participants) and euthyroid group (n = 925, 81%)...
April 24, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28438476/fulfilling-the-psychological-and-information-need-of-the-family-members-of-critically-ill-patients-using-interactive-mobile-technology-a-randomised-controlled-trial
#16
Vico Chung Lim Chiang, Rainbow Lai Ping Lee, Fung Mei Ho, Chi Kwong Leung, Yi Pui Tang, Wing Sze Wong, Yee Sin Ho, Yan Wai Tung, Hang Louie Lai
BACKGROUND: Intensive care nurses may have an important role in empowering families by providing psychological support and fulfilling the family's pivotal need for information. AIM: To determine whether 'education of families by tab' about the patient's condition was more associated with improved anxiety, stress, and depression levels than the 'education of families by routine'. RESEARCH DESIGN: A randomized control trial of 74 main family caregivers (intervention: 39; control: 35)...
April 21, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28437538/effects-of-diagnosis-by-newborn-screening-for-cystic-fibrosis-on-weight-and-length-in-the-first-year-of-life
#17
Daniel H Leung, Sonya L Heltshe, Drucy Borowitz, Daniel Gelfond, Margaret Kloster, James E Heubi, Michael Stalvey, Bonnie W Ramsey
Importance: Since the implementation of universal newborn screening (NBS) for cystic fibrosis (CF), the timing and magnitude of growth deficiency or its association with correlates of disease among infants with CF who underwent NBS has not been well described. Objective: To examine incremental weight gain, linear growth, and clinical features in the first year of life among infants with CF who underwent NBS. Design, Setting, and Participants: The Baby Observational and Nutrition Study (BONUS), a multicenter, longitudinal, observational cohort study, was conducted during regular CF clinic visits in the first 12 months of life at 28 US Cystic Fibrosis Foundation-accredited Care Centers from January 7, 2012, through May 31, 2015...
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28437072/the-single-disulfide-directed-%C3%AE-hairpin-fold-dynamics-stability-and-engineering
#18
Balasubramanyam Chittoor, Krishnarjuna Bankala, Rodrigo A W Morales, Christopher Andrew MacRaild, Maiada Sadek, Eleanor Ww Leung, Samuel Robinson, Michael Pennington, Raymond S Norton
Grafting bioactive peptide sequences onto small cysteine-rich scaffolds is a promising strategy to enhance their stability and value in novel peptide-based therapeutics. However, correctly folded disulfide-rich peptides can be challenging to produce by either recombinant or synthetic means. The single disulfide-directed β-hairpin (SDH) fold, first observed in contryphan-Vc1, provides a potential alternative to complex disulfide-rich scaffolds. We have undertaken recombinant production of full-length contryphan-Vc1 (rCon-Vc1[Z1Q]) and a truncated analog (rCon-Vc11-22[Z1Q]), analyzed the backbone dynamics of rCon-Vc1[Z1Q], and probed the conformational and proteolytic stability of these peptides to evaluate the potential of contryphan-Vc1 as a molecular scaffold...
April 24, 2017: Biochemistry
https://www.readbyqxmd.com/read/28436622/congenital-intestinal-fibrosarcoma-with-rapid-recurrence-requiring-adjuvant-chemotherapy
#19
Wing Shan Queenie See, Daniel Ka Leung Cheuk, Ka Fai To, Philip Pun Ching Ip, Alan Kwok Shing Chiang, Shau Yin Ha, Godfrey Chi Fung Chan
A total of 16 cases of congenital fibrosarcoma have been reported from 1975 to March 2015. Five of the 16 had abnormal fusion between erythroblast transformation specific translocation variant 6 and neurotrophin recptor gene neurotrophic tyrosine kinase, receptor, type 3 (ETV6-NTRK3); in another five out of 16 this was absent, and six were not tested. All were managed by surgical resection but none involved metastasis. Herein we report the case of a newborn baby girl with congenital fibrosarcoma negative for ETV6-NTRK3 gene fusion, who presented with ileal perforation and positive resection margin...
April 24, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28436083/the-added-value-of-world-views-over-self-views-predicting-modest-behaviour-in-eastern-and-western-cultures
#20
Sylvia Xiaohua Chen, Jacky C K Ng, Emma E Buchtel, Yanjun Guan, Hong Deng, Michael Harris Bond
Personality research has been focused on different aspects of the self, including traits, attitudes, beliefs, goals, and motivation. These aspects of the self are used to explain and predict social behaviour. The present research assessed generalized beliefs about the world, termed 'social axioms' (Leung et al., ), and examined their additive power over beliefs about the self in explaining a communal behaviour, that is, modesty. Three studies predicted reported modest behaviour among Mainland Chinese, Hong Kong Chinese, East Asian Canadians, and European Canadians...
April 24, 2017: British Journal of Social Psychology
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