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https://www.readbyqxmd.com/read/29785201/speed-breeding-for-multiple-quantitative-traits-in-durum-wheat
#1
Samir Alahmad, Eric Dinglasan, Kung Ming Leung, Adnan Riaz, Nora Derbal, Kai P Voss-Fels, Jason A Able, Filippo M Bassi, Jack Christopher, Lee T Hickey
Background: Plant breeding requires numerous generations to be cycled and evaluated before an improved cultivar is released. This lengthy process is required to introduce and test multiple traits of interest. However, a technology for rapid generation advance named 'speed breeding' was successfully deployed in bread wheat ( Triticum aestivum L.) to achieve six generations per year while imposing phenotypic selection for foliar disease resistance and grain dormancy. Here, for the first time the deployment of this methodology is presented in durum wheat ( Triticum durum Desf...
2018: Plant Methods
https://www.readbyqxmd.com/read/29782540/monte-carlo-simulations-of-microtubule-arrays-the-critical-roles-of-rescue-transitions-the-cell-boundary-and-tubulin-concentration-in-shaping-microtubule-distributions
#2
Lynne Cassimeris, Jessica C Leung, David J Odde
Microtubules are dynamic polymers required for a number of processes, including chromosome movement in mitosis. While regulators of microtubule dynamics have been well characterized, we lack a convenient way to predict how the measured dynamic parameters shape the entire microtubule system within a cell, or how the system responds when specific parameters change in response to internal or external signals. Here we describe a Monte Carlo model to simulate an array of dynamic microtubules from parameters including the cell radius, total tubulin concentration, microtubule nucleation rate from the centrosome, and plus end dynamic instability...
2018: PloS One
https://www.readbyqxmd.com/read/29782034/trigeminal-nerve-sheath-tumor-presenting-as-a-cluster-headache
#3
Ario Mirian, Adrian Budhram, Andrew Leung, Michelle-Lee Jones
No abstract text is available yet for this article.
May 21, 2018: Headache
https://www.readbyqxmd.com/read/29781391/hypercorrection-of-high-confidence-errors-in-the-classroom
#4
Shana K Carpenter, Cynthia L Haynes, Daniel Corral, Kam Leung Yeung
People often have erroneous knowledge about the world that is firmly entrenched in memory and endorsed with high confidence. Although strong errors in memory would seem difficult to "un-learn," evidence suggests that errors are more likely to be corrected through feedback when they are originally endorsed with high confidence compared to low confidence. This hypercorrection effect has been predominantly studied in laboratory settings with general knowledge (i.e., trivia) questions, however, and has not been systematically explored in authentic classroom contexts...
May 19, 2018: Memory
https://www.readbyqxmd.com/read/29779834/economic-evaluation-of-a-multi-disciplinary-community-based-intervention-programme-for-new-zealand-children-and-adolescents-with-obesity
#5
Yvonne C Anderson, William Leung, Cameron C Grant, Tami L Cave, José G B Derraik, Wayne S Cutfield, Nicola M Pereira, Paul L Hofman, Trudy A Sullivan
OBJECTIVE: To determine whether Whānau Pakari, a home-based, 12-month multi-disciplinary child obesity intervention programme was cost-effective when compared with the prior conventional hospital-based model of care. METHODS: Whānau Pakari trial participants were recruited January 2012-August 2014, and randomised to either a high-intensity intervention (weekly sessions for 12 months with home-based assessments and advice, n=100) or low-intensity control (home-based assessments and advice only, n=99)...
May 17, 2018: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29779828/followership-a-review-of-the-literature-in-healthcare-and-beyond
#6
REVIEW
Caleb Leung, Amanda Lucas, Peter Brindley, Shellie Anderson, Jason Park, Ashley Vergis, Lawrence M Gillman
INTRODUCTION: Research in healthcare leadership has focused on leaders. In contrast, organizational success may be more influenced by followers. Kelley described five followership styles based on two characteristics: active engagement and independent critical thinking. We examined the literature on the association between followership style and workplace outcomes. METHODS: Articles from MEDLINE, CINAHL, and EMBASE were searched. Given the paucity of studies, we expanded our search to non-healthcare databases...
May 6, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29779800/treatment-strategies-and-survival-outcomes-in-older-women-with-breast-cancer-a-comparative-study-between-the-focus-cohort-and-nottingham-cohort
#7
Hugo Schuil, Marloes Derks, Gerrit-Jan Liefers, Johanneke Portielje, Cornelis van de Velde, Binafsha Syed, Andrew Green, Ian Ellis, Kwok-Leung Cheung, Esther Bastiaannet
OBJECTIVE: Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational cohort. MATERIALS AND METHODS: Women aged 70 years and older diagnosed with breast cancer after 1990 with a T0-T2 tumor stage and no evidence of metastatic disease were included from a population-based cohort in the Netherlands and a British hospital-based cohort in Nottingham...
May 18, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29779609/gastrointestinal-endoscopy-editorial-board-top-10-topics-advances-in-gi-endoscopy-in-2017
#8
David J Desilets, Joo Ha Hwang, Kondal R Kyanam Kabir Baig, Felix W Leung, Jennifer L Maranki, Girish Mishra, Raj J Shah, Lee L Swanstrom, Amitabh Chak
No abstract text is available yet for this article.
May 17, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29779385/nutritional-available-seleno-amino-acid-derivative-antagonizes-cisplatin-induced-nephrotoxicity-through-inhibition-of-ros-mediated-signaling-pathways
#9
Xiaoling Li, Haobin Zhang, Leung Chan, Chang Liu, Tianfeng Chen
Discovery of nutritionally available agents that could antagonize cisplatin-induced nephrotoxicity is of great significance and clinical application potential. 3,3'-Diselenodipropionic acid (DSePA) is a seleno-amino acid derivative that exhibits strong antioxidant activity. Therefore, this study aimed to examine the protective effects of DSePA on cisplatin-induced nephrotoxicity as well as the molecular mechanisms. The results revealed that DSePA effectively inhibited cell apoptosis induced by cisplatin, through suppressing the caspases activation and PARP cleavage...
May 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29778140/corrigendum-to-validation-of-a-testosterone-and-dihydrotestosterone-liquid-chromatography-tandem-mass-spectrometry-assay-interference-and-comparison-with-established-methods-steroids-volume-73-issue-13-12-december-2008-pages-1345-1352
#10
Christina Wang, Steve Shiraishi, Andrew Leung, Sima Baravarian, Laura Hull, Victor Goh, Paul W N Lee, Ronald S Swerdloff
No abstract text is available yet for this article.
July 2018: Steroids
https://www.readbyqxmd.com/read/29777990/delayed-school-start-time-is-associated-with-better-sleep-daytime-functioning-and-life-satisfaction-in-residential-high-school-students
#11
Christian S Chan, Cyanea Y S Poon, Jacklyn C Y Leung, Kristy N T Lau, Esther Y Y Lau
The effects of a delayed school start time by one hour were examined at a boarding school in Hong Kong. Two cohorts of high school students (N = 228; 61.8% female) were recruited respectively before and after a school start time changed from 7:30am to 8:30am. Both cross-cohort and within-cohort longitudinal comparisons yielded significant increase in total sleep time. Cross-cohort comparison yielded improvement in sleep quality, insomnia, life satisfaction, and psychological distress. Longitudinal data suggested that the longer the additional sleep time, the better was sleep quality, day-time functioning, and subjective wellbeing...
May 16, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29777274/the-natural-agent-4-vinylphenol-targets-metastasis-and-stemness-features-in-breast-cancer-stem-like-cells
#12
Hoi-Wing Leung, Chun-Hay Ko, Grace Gar-Lee Yue, Ingrid Herr, Clara Bik-San Lau
BACKGROUND AND PURPOSE: Cancer stem-like cells (CSC) are regarded as the source of tumour origins, metastasis and drug resistance, and limits current treatment regimens. Previously, we reported the first study of the anti-angiogenic and anti-tumour activities of 4-vinylphenol. To further examine the therapeutic role of 4-vinylphenol, the inhibitory effects of 4-vinylphenol on cancer stemness, drug resistance and metastasis in breast cancer were investigated in the present study. STUDY DESIGN AND METHODS: We enriched parental MDA-MB-231 cells with CSCs in serum-free medium to give spheroids...
May 18, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29777227/in-utero-exposure-to-gestational-diabetes-and-adiposity-does-breastfeeding-make-a-difference
#13
L L Hui, A M Li, E A S Nelson, G M Leung, S L Lee, C M Schooling
BACKGROUND/OBJECTIVES: Short-term breastfeeding from mothers with gestational diabetes (GDM) may programme metabolism and increase offspring diabetes risk. We examined the association of in utero GDM exposure with adiposity from infancy to adolescence, and whether any association was modified by breastfeeding during early infancy. METHODS: In the prospective Chinese birth cohort "Children of 1997" (n = 7342, 88% follow-up rate), generalised estimate equations with multiple imputation were used to assess associations of in utero GDM exposure with age- and sex-specific body mass index (BMI) z-score during infancy (3 and 9 months), childhood (2- < 8 years) and adolescence (8-16 years), adjusted for sex, parity, maternal age, birth place, preeclampisa, smoking, and family socio-economic position...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29775858/when-is-the-right-hemisphere-holistic-and-when-is-it-not-the-case-of-chinese-character-recognition
#14
Harry K S Chung, Jacklyn C Y Leung, Vienne M Y Wong, Janet H Hsiao
Holistic processing (HP) has long been considered a characteristic of right hemisphere (RH) processing. Indeed, holistic face processing is typically associated with left visual field (LVF)/RH processing advantages. Nevertheless, expert Chinese character recognition involves reduced HP and increased RH lateralization, presenting a counterexample. Recent modeling research suggests that RH processing may be associated with an increase or decrease in HP, depending on whether spacing or component information was used respectively...
May 15, 2018: Cognition
https://www.readbyqxmd.com/read/29774400/cost-effectiveness-of-osteoporosis-screening-strategies-for-hip-fracture-prevention-in-older-chinese-people-a-decision-tree-modeling-study-in-the-mr-os-and-ms-os-cohort-in-hong-kong
#15
Y Su, F T T Lai, B H K Yip, J C S Leung, T C Y Kwok
Despite the high costs of hip fracture, many governments provide limited support for osteoporosis screening. We demonstrated that osteoporosis screening by dual-energy X-ray absorptiometry (DXA) with or without pre-screening by Fracture Risk Assessment Tool (FRAX) or calcaneal ultrasound are more cost-effective than no screening in Chinese people aged 65 or over in Hong Kong. INTRODUCTION: To examine the cost-effective potential osteoporosis screening strategies for hip fracture prevention in Hong Kong...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29774150/the-effect-of-off-hours-hospital-admission-on-mortality-and-clinical-outcomes-for-patients-with-upper-gastrointestinal-hemorrhage-a-systematic-review-and-meta-analysis-of-20-cohorts
#16
Xian Feng Xia, Philip Wai Yan Chiu, Kelvin Kam Fai Tsoi, Francis Ka Leung Chan, Joseph Jao Yiu Sung, James Yun Wong Lau
Objective: The objective of this article is to evaluate the relationship between off-hours hospital admission (weekends, public holidays or nighttime) and mortality for upper gastrointestinal hemorrhage (UGIH). Methods: Medline, Embase, Scopus, and the Chinese Biomedical Literature were searched through December 2016 to identify eligible records for inclusion in this meta-analysis. A random-effects model was applied. Results: Twenty cohort studies were included for analysis...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29773820/genetic-diversity-of-prrsv-1-in-central-eastern-europe-in-1994-2014-origin-and-evolution-of-the-virus-in-the-region
#17
Gyula Balka, Katarzyna Podgórska, Manreetpal Singh Brar, Ádám Bálint, Daniel Cadar, Vladimir Celer, Lilla Dénes, Zuzana Dirbakova, Anna Jedryczko, Lázár Márton, Dinko Novosel, Tamaš Petrović, Ivo Sirakov, Dóra Szalay, Ivan Toplak, Frederick Chi-Ching Leung, Tomasz Stadejek
More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the authors collected and analyzed both recent as well as already submitted sequences comparing them to a large backbone set of available ORF5 sequences representing the full spectrum of PRRSV 1 Subtype 1 diversity to conduct a systematic phylogenetic analysis and reclassification elucidating the diversity of the virus in these countries...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773243/impact-of-diabetes-and-increasing-body-mass-index-category-on-left-ventricular-systolic-and-diastolic-function
#18
Arnold C T Ng, Francesca Prevedello, Giulia Dolci, Cornelis J Roos, Roxana Djaberi, Matteo Bertini, See Hooi Ewe, Christine Allman, Dominic Y Leung, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
BACKGROUND: Diabetes and obesity are both worldwide growing epidemics, and both are independently associated with increased risk for heart failure and death. The aim of this study was to examine the additive detrimental effect of both diabetes and increasing body mass index (BMI) category on left ventricular (LV) myocardial systolic and diastolic function. METHODS: The present retrospective multicenter study included 653 patients (337 with type 2 diabetes and 316 without diabetes) of increasing BMI category...
May 15, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29772675/silencing-stem-cell-factor-gene-in-fibroblasts-to-regulate-paracrine-factor-productions-and-enhance-c-kit-expression-in-melanocytes-on-melanogenesis
#19
Pin-Hui Li, Li-Heng Liu, Cheng-Chung Chang, Rong Gao, Chung-Hang Leung, Dik-Lung Ma, Hui-Min David Wang
Melanogenesis is a complex physiological mechanism involving various paracrine factors. Skin cells such as keratinocytes, fibroblasts, and melanocytes communicate with one another through secreted regulators, thereby regulating the melanocytes' bio-functions. The stem cell factor (SCF) is a paracrine factor produced by fibroblasts, and its receptor, c-kit, is expressed on melanocytes. Binding of SCF to c-kit activates autophosphorylation and tyrosine kinase to switch on its signal transmission. SCF inhibition does not suppress fibroblast proliferation in MTT assay, and SCF silencing induced mRNA expressions of paracrine factor genes, HGF , NRG-1 , and CRH in qPCR results...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772270/identification-of-certain-panax-species-to-be-potential-substitutes-for-panax-notoginseng-in-hemostatic-treatments
#20
REVIEW
Bin Rui Yang, Sze Chung Yuen, Guang Yi Fan, Wei-Hong Cong, Siu-Wai Leung, Simon Ming-Yuen Lee
Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow (P. notoginseng) is a highly valued Chinese materia medica having a hemostatic effect and mainly used for the treatment of trauma and ischemic cardiovascular diseases. Stringent growth requirements, weak resistance to insect pests and plant diseases, arsenic contamination and continuous cropping constitute hurdles to further increases in the agricultural production of P. notoginseng. This review focuses on the traditional uses (based on traditional Chinese medicine theory), major chemical components, biological activities, pharmacological properties, geographical distributions and historical development of taxonomy of P...
May 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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