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https://www.readbyqxmd.com/read/28525495/national-cancer-database-report-of-lymphadenectomy-trends-in-endometrial-cancer
#1
James Cripe, Elizabeth Handorf, Jennifer Brown, Angela Jain, Stephen Rubin, Gina Mantia-Smaldone
OBJECTIVES: Lymph node involvement has a significant impact on prognosis that may direct adjuvant therapy. The role of routine lymph node staging (LNS) is controversial given conflicting results in multiple studies. Our aims are to describe treatment patterns of LNS, identify factors impacting LNS, and quantify the contemporary trends. METHODS/MATERIALS: The National Cancer Data Base was queried for patients undergoing hysterectomy for endometrioid and serous uterine carcinomas from 2003 to 2012...
May 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28502486/jcl-roundtable-cardiovascular-disease-risk-reduction-in-menopausal-women
#2
REVIEW
William Virgil Brown, Martha Gulati, Gina P Lundberg
Ovarian failure occurs in most women during the late fifth decade or early sixth decade of life. This causes a number of changes in physiology as estrogen and progestin concentrations decline. These involve lipoprotein metabolism and the vasculature. The risk factors for large vessel disease increase, and dysfunction of the small resistance vessels responds with changes in blood flow to the skin causing unpleasant symptoms. These and other changes result in visits to the physician. A reassessment of risk factors and symptoms is needed to develop a new plan for effective management, both short term and long term...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28476941/systemic-chemotherapy-as-salvage-treatment-for-locally-advanced-rectal-cancer-patients-who-fail-to-respond-to-standard-neoadjuvant-chemoradiotherapy
#3
Francesco Sclafani, Gina Brown, David Cunningham, Sheela Rao, Paris Tekkis, Diana Tait, Federica Morano, Chiara Baratelli, Eleftheria Kalaitzaki, Shahnawaz Rasheed, David Watkins, Naureen Starling, Andrew Wotherspoon, Ian Chau
BACKGROUND: The potential of chemotherapy as salvage treatment after failure of neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC) has never been explored. We conducted a single-center, retrospective analysis to address this question. PATIENTS AND METHODS: Patients with newly diagnosed LARC who were inoperable or candidates for extensive (i.e., beyond total mesorectal excision [TME]) surgery after long-course chemoradiotherapy and who received salvage chemotherapy were included...
May 5, 2017: Oncologist
https://www.readbyqxmd.com/read/28472756/development-and-validation-of-innoquant-%C3%A2-hy-a-system-for-quantitation-and-quality-assessment-of-total-human-and-male-dna-using-high-copy-targets
#4
Andrew Loftus, Gina Murphy, Hiromi Brown, Anne Montgomery, Jonathan Tabak, James Baus, Marion Carroll, André Green, Suresh Sikka, Sudhir Sinha
The development and validation of InnoQuant(®) HY, a real-time PCR system containing four DNA targets-two RE autosomal targets of different sizes, male specific targets, and an internal positive control target-are described herein. The ratio of the two autosomal targets provides a Degradation Index, or a quantitative value of a sample's degradation state. The male specific targets are multi-copy targets located on the Y chromosome, which provides information about a sample's male DNA composition. The experimental results demonstrate InnoQuant HY as a robust qPCR method producing accurate DNA quantitation results even at low dynamic ranges, with reproducibility among population groups...
April 17, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28449006/a-meta-analysis-comparing-the-risk-of-metastases-in-patients-with-rectal-cancer-and-mri-detected-extramural-vascular-invasion-mremvi-vs-mremvi-negative-cases
#5
Muhammed R S Siddiqui, Constantinos Simillis, Chris Hunter, Manish Chand, Jemma Bhoday, Aurelie Garant, Te Vuong, Giovanni Artho, Shahnawaz Rasheed, Paris Tekkis, Al-Mutaz Abulafi, Gina Brown
BACKGROUND: Pathological extramural vascular invasion (EMVI) is an independent prognostic factor in rectal cancer, but can also be identified on MRI-detected extramural vascular invasion (mrEMVI). We perform a meta-analysis to determine the risk of metastatic disease at presentation and after surgery in mrEMVI-positive patients compared with negative tumours. METHODS: Electronic databases were searched from January 1980 to March 2016. Conventional meta-analytical techniques were used to provide a summative outcome...
April 27, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28448250/recruiting-community-partners-for-veggie-van-strategies-and-lessons-learned-from-a-mobile-market-intervention-in-north-carolina-2012-2015
#6
Gina L Tripicchio, Jacqueline Grady Smith, Janelle Armstrong-Brown, Jared McGuirt, Lindsey Haynes-Maslow, Sarah Mardovich, Alice S Ammerman, Lucia Leone
BACKGROUND: Food access interventions are promising strategies for improving dietary intake, which is associated with better health. However, studies examining the relationship between food access and intake are limited to observational designs, indicating a need for more rigorous approaches. The Veggie Van (VV) program was a cluster-randomized intervention designed to address the gap between food access and intake. In this article, we aim to describe the approaches involved in recruiting community partners to participate in VV...
April 27, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28391141/development-and-validation-of-a-novel-multiplexed-dna-analysis-system-innotyper-%C3%A2-21
#7
Hiromi Brown, Robyn Thompson, Gina Murphy, Dixie Peters, Bobby La Rue, Jonathan King, Anne H Montgomery, Marion Carroll, James Baus, Sid Sinha, Frank R Wendt, Bing Song, Ranajit Chakraborty, Bruce Budowle, Sudhir K Sinha
We report here a novel multiplexed DNA analysis system consisting of 20 Alu markers and Amelogenin for analysis of highly degraded forensic biological samples. The key to the success of the system in obtaining results from degraded samples is the primer design yielding small amplicon size (60-125bp) for all 20 markers. The markers included in the InnoTyper(®) 21 system are bi-allelic, having two possible allelic states (insertion or null) and thus termed INNULs. The markers are short interspersed nuclear elements (SINEs), a category of retrotransposable elements (REs) which are non-coding genomic DNA repeat sequences, or "mobile insertion elements," comprising approximately 40% of the human genome...
March 18, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28369965/canine-cranial-cruciate-ligament-deficient-stifle-biomechanics-associated-with-extra-articular-stabilization-predicted-using-a-computer-model
#8
Nathan P Brown, Gina E Bertocci, Denis J Marcellin-Little
OBJECTIVE: To evaluate lateral fabellotibial suture (LFTS) and TightRope CCL (TR) extra-articular stabilization biomechanics in the cranial cruciate ligament (CrCL)-deficient canine stifle joint during the stance phase of gait. STUDY DESIGN: Computer simulations. ANIMALS: Healthy 33-kg Golden Retriever. METHODS: LFTS and TR were implemented in a previously developed 3-D quasi-static rigid body CrCL-deficient canine pelvic limb computer model simulating the stance phase of gait...
April 1, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28323938/loss-of-action-via-neurotensin-leptin-receptor-neurons-disrupts-leptin-and-ghrelin-mediated-control-of-energy-balance
#9
Juliette A Brown, Raluca Bugescu, Thomas Mayer, Adriana Gata-Garcia, Gizem Kurt, Hillary L Woodworth, Gina M Leinninger
The hormones ghrelin and leptin act via the lateral hypothalamic area (LHA) to modify energy balance but the underlying neural mechanisms remain unclear. We investigated how leptin and ghrelin engage LHA neurons to modify energy balance behaviors and whether there is any cross-talk between leptin and ghrelin-responsive circuits. We demonstrate that ghrelin activates LHA neurons expressing Hypocretin/Orexin (OX) to increase food intake. Leptin mediates anorectic actions via separate neurons expressing the long form of the leptin receptor (LepRb), many of which co-express the neuropeptide neurotensin (Nts); we refer to these as NtsLepRb neurons...
March 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/28221318/evaluating-and-treating-mammalian-bites
#10
Donna Rasmussen, Alexandra Landon, Jennifer Powell, Gina R Brown
Mammalian bites, typically from dogs, cats, or humans, are a common presentation in EDs and family practice settings, and patients present with varying degrees of complexity. Injuries can range from local to systemic, including aggressive bacterial infections and permanent limb impairment. Using a systematic approach to initial wound assessment, followed by appropriate diagnostic testing and treatment, is critical to improved long-term patient outcomes.
March 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28130592/extended-lymphadenectomy-for-locally-advanced-and-recurrent-rectal-cancer
#11
Panagiotis A Georgiou, S Mohammed Ali, Gina Brown, Shahnawaz Rasheed, Paris P Tekkis
PURPOSE: The purpose of this study is to assess the value of extended (lateral) lymphadenectomy (EL) in the operative management of locally advanced and recurrent rectal cancer. METHODS: Patients that underwent exenterative surgery for locally advanced or recurrent rectal cancer between 2006 and 2009 were included in the study. A decision for EL was taken at the local multidisciplinary meeting based on the radiological findings. Perioperative and oncological outcomes were assessed and compared between the EL and non-EL group prospectively...
March 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28029280/biomechanics-of-an-orthosis-managed-cranial-cruciate-ligament-deficient-canine-stifle-joint-predicted-by-use-of-a-computer-model
#12
Gina E Bertocci, Nathan P Brown, Patrice M Mich
OBJECTIVE To evaluate effects of an orthosis on biomechanics of a cranial cruciate ligament (CrCL)-deficient canine stifle joint by use of a 3-D quasistatic rigid-body pelvic limb computer model simulating the stance phase of gait and to investigate influences of orthosis hinge stiffness (durometer). SAMPLE A previously developed computer simulation model for a healthy 33-kg 5-year-old neutered Golden Retriever. PROCEDURES A custom stifle joint orthosis was implemented in the CrCL-deficient pelvic limb computer simulation model...
January 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27913603/the-tumor-suppressor-flcn-mediates-an-alternate-mtor-pathway-to-regulate-browning-of-adipose-tissue
#13
Shogo Wada, Michael Neinast, Cholsoon Jang, Yasir H Ibrahim, Gina Lee, Apoorva Babu, Jian Li, Atsushi Hoshino, Glenn C Rowe, James Rhee, José A Martina, Rosa Puertollano, John Blenis, Michael Morley, Joseph A Baur, Patrick Seale, Zoltan Arany
Noncanonical mechanistic target of rapamycin (mTOR) pathways remain poorly understood. Mutations in the tumor suppressor folliculin (FLCN) cause Birt-Hogg-Dubé syndrome, a hamartomatous disease marked by mitochondria-rich kidney tumors. FLCN functionally interacts with mTOR and is expressed in most tissues, but its role in fat has not been explored. We show here that FLCN regulates adipose tissue browning via mTOR and the transcription factor TFE3. Adipose-specific deletion of FLCN relieves mTOR-dependent cytoplasmic retention of TFE3, leading to direct induction of the PGC-1 transcriptional coactivators, drivers of mitochondrial biogenesis and the browning program...
November 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27898754/genome-wide-association-mapping-of-fusarium-head-blight-resistance-in-wheat-using-genotyping-by-sequencing
#14
Marcio P Arruda, Patrick Brown, Gina Brown-Guedira, Allison M Krill, Carrie Thurber, Keith R Merrill, Bradley J Foresman, Frederic L Kolb
Fusarium head blight (FHB) is one of the most important wheat ( L.) diseases worldwide, and host resistance displays complex genetic control. A genome-wide association study (GWAS) was performed on 273 winter wheat breeding lines from the midwestern and eastern regions of the United States to identify chromosomal regions associated with FHB resistance. Genotyping-by-sequencing (GBS) was used to identify 19,992 single-nucleotide polymorphisms (SNPs) covering all 21 wheat chromosomes. Marker-trait associations were performed with different statistical models, the most appropriate being a compressed mixed linear model (cMLM) controlling for relatedness and population structure...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27889036/diagnosis-and-diagnostic-imaging-of-anal-canal-cancer
#15
REVIEW
Kristen K Ciombor, Randy D Ernst, Gina Brown
Anal canal cancer is an uncommon malignancy but one that is often curable with optimal therapy. Owing to its unique location, histology, risk factors, and usual presentation, a careful diagnostic approach is warranted. This approach includes an excellent history and physical examination, including digital rectal examination, laboratory data, and comprehensive imaging. Anal cancer staging and formulation of a treatment plan depends on accurate imaging data. Modern radiographic techniques have improved staging quality and accuracy, and a thorough knowledge of anal anatomy is paramount to the optimal multidisciplinary treatment of this disease...
January 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27872117/protocol-for-a-multicentre-randomised-feasibility-trial-evaluating-early-surgery-alone-in-low-rectal-cancer-sailor
#16
Dean A Harris, Kymberley Thorne, Hayley Hutchings, Saiful Islam, Gail Holland, Olivia Hatcher, Sarah Gwynne, Ian Jenkins, Peter Coyne, Michael Duff, Melanie Feldman, Des C Winter, Simon Gollins, Phil Quirke, Nick West, Gina Brown, Deborah Fitzsimmons, Alan Brown, John Beynon
INTRODUCTION: There are 11 500 rectal cancers diagnosed annually in the UK. Although surgery remains the primary treatment, there is evidence that preoperative radiotherapy (RT) improves local recurrence rates. High-quality surgery in rectal cancer is equally important in minimising local recurrence. Advances in MRI-guided prediction of resection margin status and improvements in abdominoperineal excision of the rectum (APER) technique supports a reassessment of the contribution of preoperative RT...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27856295/street-smarts-and-a-scalpel-emotional-intelligence-in-surgical-education
#17
Mary Kate Erdman, Alisha Bonaroti, Gina Provenzano, Rachel Appelbaum, Marybeth Browne
OBJECTIVE: To evaluate trends of emotional intelligence (EI) in surgical education and to compare the incorporation of EI in surgical education to other fields of graduate medical education. DESIGN: A MEDLINE search was performed for publications containing both "surgery" and "emotional intelligence" with at least one term present in the title. Articles were included if the authors deemed EI in surgical education to be a significant focus. A separate series of MEDLINE searches were performed with the phrase "emotional intelligence" in any field and either "surg*," "internal medicine," "pediatric," "neurology," "obstetric," "gynecology," "OBGYN," "emergency," or "psychiat*" in the title...
March 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/27852235/enrichment-dynamics-of-listeria-monocytogenes-and-the-associated-microbiome-from-naturally-contaminated-ice-cream-linked-to-a-listeriosis-outbreak
#18
Andrea Ottesen, Padmini Ramachandran, Elizabeth Reed, James R White, Nur Hasan, Poorani Subramanian, Gina Ryan, Karen Jarvis, Christopher Grim, Ninalynn Daquiqan, Darcy Hanes, Marc Allard, Rita Colwell, Eric Brown, Yi Chen
BACKGROUND: Microbiota that co-enrich during efforts to recover pathogens from foodborne outbreaks interfere with efficient detection and recovery. Here, dynamics of co-enriching microbiota during recovery of Listeria monocytogenes from naturally contaminated ice cream samples linked to an outbreak are described for three different initial enrichment formulations used by the Food and Drug Administration (FDA), the International Organization of Standardization (ISO), and the United States Department of Agriculture (USDA)...
November 16, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27775500/molecular-mapping-of-stem-rust-resistance-loci-effective-against-the-ug99-race-group-of-the-stem-rust-pathogen-and-validation-of-a-single-nucleotide-polymorphism-marker-linked-to-stem-rust-resistance-gene-sr28
#19
E M Babiker, T C Gordon, S Chao, M N Rouse, R Wanyera, M Acevedo, G Brown-Guedira, J M Bonman
Wheat landrace PI 177906 has seedling resistance to stem rust caused by Puccinia graminis f. sp. tritici races TTKSK, TTKST, and BCCBC and field resistance to the Ug99 race group. Parents, 140 recombinant inbred lines, and 138 double haploid (DH) lines were evaluated for seedling resistance to races TTKSK and BCCBC. Parents and the DH population were evaluated for field resistance to Ug99 in Kenya. The 90K wheat single nucleotide polymorphism (SNP) genotyping platform was used to genotype the parents and populations...
February 2017: Phytopathology
https://www.readbyqxmd.com/read/27748747/vessel-co-option-mediates-resistance-to-anti-angiogenic-therapy-in-liver-metastases
#20
Sophia Frentzas, Eve Simoneau, Victoria L Bridgeman, Peter B Vermeulen, Shane Foo, Eleftherios Kostaras, Mark R Nathan, Andrew Wotherspoon, Zu-Hua Gao, Yu Shi, Gert Van den Eynden, Frances Daley, Clare Peckitt, Xianming Tan, Ayat Salman, Anthoula Lazaris, Patrycja Gazinska, Tracy J Berg, Zak Eltahir, Laila Ritsma, Jacco van Rheenen, Alla Khashper, Gina Brown, Hanna Nyström, Malin Sund, Steven Van Laere, Evelyne Loyer, Luc Dirix, David Cunningham, Peter Metrakos, Andrew R Reynolds
The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that are poorly understood. Notably, instead of through the induction of angiogenesis, tumor vascularization can occur through the nonangiogenic mechanism of vessel co-option. Here we show that vessel co-option is associated with a poor response to the anti-angiogenic agent bevacizumab in patients with colorectal cancer liver metastases. Moreover, we find that vessel co-option is also prevalent in human breast cancer liver metastases, a setting in which results with anti-angiogenic therapy have been disappointing...
November 2016: Nature Medicine
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