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Septal myectomy

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https://www.readbyqxmd.com/read/28642712/investigations-into-the-sarcomeric-protein-and-ca-2-regulation-abnormalities-underlying-hypertrophic-cardiomyopathy-in-cats-felix-catus
#1
Andrew E Messer, Jasmine Chan, Alex Daley, O'Neal Copeland, Steven B Marston, David J Connolly
Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Homozygous MYBPC3 mutations have been identified in these breeds but the mutations in other cats are unknown. At the clinical and physiological level feline HCM is closely analogous to human HCM but little is known about the primary causative mechanism. Most identified HCM causing mutations are in the genes coding for proteins of the sarcomere...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28609808/resection-of-subaortic-membrane-for-discrete-subaortic-stenosis
#2
Sachin Talwar, Abhishek Anand, Saurabh Kumar Gupta, Sivasubramanian Ramakrishnan, Shyam Sunder Kothari, Anita Saxena, Rajnish Juneja, Shiv Kumar Choudhary, Balram Airan
BACKGROUND: We reviewed the long-term results of surgery for discrete subaortic membrane (SubAM) from a single institute. METHODS: A retrospective review of medical records of all patients (n = 146) who underwent resection of a SubAM for discrete subaortic stenosis between 1990 and 2015 at the All India Institute of Medical Sciences, New Delhi, India was undertaken. RESULTS: Median age at surgery was 9.0 years (9 months-47 years). There was one early death...
June 13, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28483207/usefulness-of-preoperative-transforming-growth-factor-beta-to-predict-new-onset-atrial-fibrillation-after-surgical-ventricular-septal-myectomy-in-patients-with-obstructive-hypertrophic-cardiomyopathy
#3
Ying Guo, Xi Wu, Xinxin Zheng, Jie Lu, Shuiyun Wang, Xiaohong Huang
Postoperative atrial fibrillation (AF) occurs frequently after cardiac surgery and contributes significantly to mortality. Transforming growth factor-beta (TGF-β) is associated with postoperative AF after coronary artery bypass grafting and valve surgery. We performed a prospective study to evaluate the role of TGF-β as a predictor of AF after myectomy. A total of 109 consecutive obstructive hypertrophic cardiomyopathy patients without previous AF who underwent myectomy were identified. We measured plasma TGF-β levels before surgery, monitored heart rhythm until discharge, and followed patients for a mean of 36 ± 10 months...
April 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28396501/mechanism-of-progressive-heart-failure-and-significance-of-pulmonary-hypertension-in-obstructive-hypertrophic-cardiomyopathy
#4
Michele Covella, Ethan J Rowin, Nicholas S Hill, Ioana R Preston, Alberto Milan, Alexander R Opotowsky, Barry J Maron, Martin S Maron, Bradley A Maron
BACKGROUND: There are limited data on the prevalence, pathophysiology, and management implications of pulmonary hypertension in patients with obstructive hypertrophic cardiomyopathy and advanced heart failure. METHODS AND RESULTS: To assess the clinical significance of measured cardiopulmonary hemodynamics in hypertrophic cardiomyopathy patients with heart failure, we retrospectively assessed right heart catheterization data in 162 consecutive patients with outflow tract gradients (median [interquartile range], 90 mm Hg [70-110 mm Hg]), 59±11 years old, and 49% men, predominately New York Heart Association class III/IV status...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28363351/comparison-of-ventricular-septal-measurements-in-hypertrophic-cardiomyopathy-patients-who-underwent-surgical-myectomy-using-multimodality-imaging-and-implications-for-diagnosis-and-management
#5
Dermot Phelan, Brett W Sperry, Paaladinesh Thavendiranathan, Patrick Collier, Zoran B Popović, Harry M Lever, Nicholas G Smedira, Milind Y Desai
Accurate and reproducible quantification of ventricular septal (VS) thickness in hypertrophic cardiomyopathy (HC) is essential for diagnosis, surgical planning, and risk stratification. We sought to compare VS thickness measurements using transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and cardiac magnetic resonance (CMR) in patients with HC. Prospectively reported measurements of VS thickness were compared using analysis of variance and Bland-Altman plots in 90 consecutive patients with HC who underwent a TTE, TEE, and CMR within 3 months...
May 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28329292/surgical-septal-myectomy-or-alcohol-septal-ablation-which-approach-offers-better-outcomes-for-patients-with-hypertrophic-obstructive-cardiomyopathy
#6
Shi Sum Poon, Mark Field, Dhiraj Gupta, Duke Cameron
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether surgical septal myectomy (SM) is more beneficial than alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy. Altogether 218 articles were found using the reported search, of which 15 studies represented the best evidence to answer the clinical question. There were 14 observational studies and 1 meta-analysis study. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these articles are tabulated...
June 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28329110/mid-term-outcomes-of-concomitant-surgical-ablation-of-atrial-fibrillation-in-patients-undergoing-cardiac-surgery-for-hypertrophic-cardiomyopathy%C3%A2
#7
Elisabetta Lapenna, Alberto Pozzoli, Michele De Bonis, Giovanni La Canna, Teodora Nisi, Simona Nascimbene, Luca Vicentini, Stefania Di Sanzo, Benedetto Del Forno, Davide Schiavi, Ottavio Alfieri
OBJECTIVES: Atrial fibrillation (AF) is common in patients with hypertrophic cardiomyopathy (HCM) and it is often poorly tolerated because of loss of atrial contraction and reduced filling time with rapid ventricular rates. Restoring sinus rhythm is of great clinical benefit to HCM patients. Very few data exist regarding surgical ablation of concomitant AF in this setting. The aim of this study was to evaluate the mid-term outcome of surgical AF ablation in patients who underwent cardiac surgery due to HCM...
June 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28301315/time-and-age-dependent-decrease-of-nt-probnp-after-septal-myectomy-in-hypertrophic-obstructive-cardiomyopathy
#8
Hao Cui, Xi Wu, Shuiyun Wang, Bing Tang, Changsheng Zhu, Haibo Chen, Xiaohui Zhou, Rong Wu, Qinjun Yu, Xiaohong Huang
BACKGROUND: NT-proBNP level is a predictive factor in hypertrophic cardiomyopathy patients, in which left ventricular outflow tract obstruction contributes to an increased NT-proBNP level. However, studies regarding the influence of septal myectomy on NT-proBNP level in hypertrophic obstructive cardiomyopathy are lacking. METHODS: One hundred and eighty-two patients who underwent septal myectomy in Fuwai Hospital from May 2011 to March 2016 and were included in the present study...
March 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28275421/treating-a-structural-heart-disease-using-a-non-structural-approach-role-of-cardiac-pacing-in-hypertrophic-cardiomyopathy
#9
Bernard Benjamin P Albano, Erdie C Fadreguilan, Jeffrey M Chua, James Ho, Ana Beatriz Medrano
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease characterized by a thickened non-dilated ventricle in the absence of another cardiac or systemic condition. Its most important hemodynamic consequence is left ventricular outflow tract (LVOT) obstruction. The primary management strategy of this condition is surgical septal myectomy, but an acceptable alternative treatment in patients who are not suitable for (or who refuse) surgery is alcohol septal ablation (ASA). However, in patients with unfavorable coronary anatomy which precludes ASA (i...
February 2017: Cardiology Research
https://www.readbyqxmd.com/read/28268009/why-we-need-more-septal-myectomy-surgeons-an-emerging-recognition
#10
EDITORIAL
Barry J Maron, Joseph A Dearani, Martin S Maron, Steve R Ommen, Hassan Rastegar, Rick A Nishimura, Daniel G Swistel, Mark V Sherrid, Anthony Ralph-Edwards, Harry Rakowski, Nicholas G Smedira, Ethan J Rowin, Milind Y Desai, Harry M Lever, Paolo Spirito, Paolo Ferrazzi, Hartzell V Schaff
No abstract text is available yet for this article.
February 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28262912/hypertrophic-angulation-deformity-of-the-basal-interventricular-septum-combined-with-abnormality-of-the-papillary-muscle-and-chordae-tendineae
#11
Yi Wang, Luwei Ye, Lixue Yin, Jie Zeng
A Chinese woman was admitted to our hospital because of syncope. Transthoracic echocardiography revealed a hypertrophic basal interventricular septum of 15 mm with a sharp angle protruding into the left ventricular outflow tract. Moreover, an anomalous anterolateral papillary muscle (maximum width of 11 mm) was inserted into the left ventricular outflow tract, with short chordae tendineae connecting both basal interventricular septum and anterior leaflet of the mitral valve. All of these abnormalities resulted in a left ventricular outflow gradient of 136 mmHg...
January 23, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28247219/concomitant-septal-myectomy-during-minimally-invasive-aortic-valve-replacement-through-a-right-mini-thoracotomy-for-the-treatment-of-aortic-stenosis-with-systolic-anterior-motion-of-the-mitral-valve
#12
Toshinori Totsugawa, Kota Suzuki, Arudo Hiraoka, Kentaro Tamura, Hidenori Yoshitaka, Taichi Sakaguchi
This paper reports concomitant septal myectomy during minimally invasive aortic valve replacement through a right mini-thoracotomy. A 76-year-old woman was diagnosed as having aortic stenosis with systolic anterior motion of the mitral valve. The bulging septum was exposed by pulling up a traction suture placed at the annulus of the right coronary cusp; the anomalous chordae and muscle bundles attached to the septum were also resected. By setting an adequate intercostal thoracotomy and placing a traction suture, concomitant myectomy was safely performed even through a right mini-thoracotomy...
March 1, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28164017/alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy-in-a-patient-with-a-chronic-total-occlusion-of-the-right-coronary-artery-beware-of-collateral-damage
#13
Quentin de Hemptinne, Fabien Picard, Philippe L L'Allier
Alcohol septal ablation (ASA) is an effective semi-invasive alternative to surgical myectomy in selected patients for the management of severely symptomatic and drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). One contraindication of this procedure is the presence of collateral flow originating from the target septal perforator to a remote myocardial territory. In such circumstances, ethanol injection could cause remote non-target myocardial necrosis in the collateralized territory. Percutaneous revascularization of the collateralized vessel prior to ASA might cope with this contraindication by restoring normal antegrade flow in the occluded artery...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28149847/does-relief-of-outflow-tract-obstruction-in-patients-with-hypertrophic-cardiomyopathy-improve-long-term-survival-implications-for-lowering-the-threshold-for-surgical-myectomy-and-alcohol-septal-ablation
#14
EDITORIAL
Srihari S Naidu, Julio A Panza, David Spielvogel, Ramin Malekan, Joshua Goldberg, Wilbert S Aronow
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28106021/endocardial-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy
#15
Tolga Aksu, Tümer Erdem Güler, Kıvanç Yalın, Şükriye Ebru Gölcük, Kazım Serhan Özcan
Septal reduction therapy (SRT) is the accepted therapeutic option for symptomatic hypertrophic obstructive cardiomyopathy (HOCM). At this time, surgical septal myectomy is the gold standard method, but alcohol septal ablation is an acceptable alternative treatment for patients with suitable anatomy. Endocardial septal ablation (ESA) therapy is a little-known method of SRT. Presently described is case of successful ESA procedure performed for HOCM.
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28099954/an-evolution-of-management-in-hypertrophic-cardiomyopathy-myectomy-alcohol-septal-ablation-mitral-valve-replacement-mitraclip
#16
Konstantinos Dean Boudoulas, Harisios Boudoulas
No abstract text is available yet for this article.
2017: Cardiology
https://www.readbyqxmd.com/read/28096824/extended-myectomy-in-the-treatment-of-patients-with-hypertrophic-obstructive-cardiomyopathy
#17
Mateusz Kuć, Piotr Kołsut, Jacek Różański, Maciej Dąbrowski, Mariusz Kłopotowski, Magda Kumor, Mirosław Kowalski, Natalia Kopyłowska, Jarosław Kuriata, Mariusz Kuśmierczyk
INTRODUCTION: Partial resection of the septal muscle is a well-established and effective method of surgical treatment for patients with hypertrophic obstructive cardiomyopathy (HOCM). The procedure is characterized by a low operative mortality rate and long-term clinical improvement that has been confirmed in numerous publications. Mitral insufficiency in patients with HOCM is mostly functional due to the effect of systolic anterior motion (SAM). AIM: To present the early results of surgical treatment provided to HOCM patients and to compare the effectiveness of two surgical procedures: isolated myectomy and myectomy combined with mitral valve replacement...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28095388/the-use-of-mitraclip-for-symptomatic-patients-with-hypertrophic-obstructive-cardiomyopathy
#18
Felix Thomas, Florian Rader, Robert J Siegel
OBJECTIVES: Current nonpharmacological therapies for symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM), including septal myectomy and alcohol septal ablation (ASA), carry significant risks for serious cardiac conduction abnormalities. We present a review of the currently available published data regarding the novel use of the relatively low-risk MitraClip® system in the treatment of symptomatic patients. METHODS: Data were collected from 4 separate studies on the use of the MitraClip on 15 symptomatic HOCM patients with systolic anterior motion (SAM) of the mitral valve apparatus...
2017: Cardiology
https://www.readbyqxmd.com/read/28068798/an-asymptomatic-septal-perforator-coronary-artery-left-ventricle-fistula-following-myectomy-in-a-patient-with-obstructive-hypertrophic-cardiomyopathy
#19
N Koutsogiannis, Ioanna Koniari, N Kounis, G Hahalis
No abstract text is available yet for this article.
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28031684/myectomy-like-extended-alcohol-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy
#20
Denisa Jahnlová, Pavol Tomašov, Josef Veselka
Currently, two therapeutic options are available for patients with drug-resistant obstructive hypertrophic cardiomyopathy. While there is a tendency in extended myectomy to perform a larger septal reduction to eliminate left ventricular outflow tract gradient more effectively, there has been a trend in recent years toward using lower dosages of alcohol during alcohol septal ablation (ASA) to reduce the risk of arrhythmic complications. We report a case of a symptomatic patient with severe septal hypertrophy who underwent an extended ASA of three septal branches...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
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