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https://www.readbyqxmd.com/read/27910944/thyroid-sclerosing-mucoepidermoid-carcinoma-with-eosinophilia-a-clinicopathologic-and-molecular-analysis-of-a-distinct-entity
#1
Akeesha A Shah, Kristin La Fortune, Caitlyn Miller, Stacey E Mills, Zubair Baloch, Virginia LiVolsi, Sanja Dacic, Alyssa L Mahaffey, Marina Nikiforova, Yuri E Nikiforov, Raja R Seethala
Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare thyroid neoplasm of uncertain pathogenesis that resembles salivary gland mucoepidermoid carcinoma. This multi-institutional study characterizes the clinicopathologic and molecular features of this tumor by utilizing next-generation sequencing to assess common mutations and gene fusions involved in thyroid carcinogenesis as well as fluorescence in-situ hybridization for MAML2 translocations typical of salivary gland mucoepidermoid carcinoma. Nine cases (6 females and 3 males, mean age: 59 years, range 30-77 years) were identified...
December 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27523965/molecular-pathology-predictive-prognostic-and-diagnostic-markers-in-salivary-gland-tumors
#2
REVIEW
Raja R Seethala, Christopher C Griffith
Although initial attempts at using ancillary studies in salivary gland tumor classification were viewed with skepticism, numerous advances over the past decade have established a role for assessment of molecular alterations in the diagnosis and potential prognosis and treatment of salivary gland tumors. Many monomorphic salivary tumors are now known to harbor defining molecular alterations, usually translocations. Pleomorphic, high-grade carcinomas tend to have complex alterations that are often further limited by inaccuracy of initial classification by morphologic and immunophenotypic features...
September 2016: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/27400918/mammary-analog-secretory-carcinoma-masc-involving-the-thyroid-gland-a-report-of-the-first-3-cases
#3
Jennifer Dettloff, Raja R Seethala, Todd M Stevens, Margaret Brandwein-Gensler, Barbara A Centeno, Kristen Otto, Julia A Bridge, Justin A Bishop, Marino E Leon
Salivary gland-type tumors have been rarely described in the thyroid gland. Mammary Analog Secretory Carcinoma (MASC) is a recently defined type of salivary gland carcinoma characterized by a t(12;15)(p13;q25) resulting in an ETV6-NTRK3 fusion gene. We report 3 cases of MASC involving the thyroid gland without clinical evidence of a salivary gland or breast primary; the clinico-pathologic characteristics are reviewed. Assessment for rearrangement of the ETV6 (12p13) locus was conducted by fluorescence in situ hybridization (FISH) on representative FFPE sections using an ETV6 break apart probe (Abbott Molecular, Des Plaines, IL, USA)...
July 11, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/26839269/cytology-of-the-salivary-glands
#4
REVIEW
Raja R Seethala
Common usage of fine-needle aspirate (FNA) for salivary gland lesions is the preoperative determination of whether a lesion is neoplastic, its lineage, and if neoplastic, whether it is low grade/benign, or high grade. Immunohistochemical stains can be performed on cell blocks to determine lineage and help refine diagnosis, although their performance is not always equivalent to that seen in surgical specimens. Several characteristic translocations have been described in various entities in these categories, and these can be evaluated using fluorescence in situ hybridization...
March 2014: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26837791/rare-malignant-and-benign-salivary-gland-epithelial-tumors
#5
Raja R Seethala, E Leon Barnes
Although at least 24 distinct histologic salivary gland carcinomas exist, many of them are rare, comprising only 1% to 2% of all salivary gland tumors. These include epithelial-myoepithelial carcinoma, (hyalinizing) clear cell carcinoma, basal cell adenocarcinoma, cystadenocarcinoma, low-grade salivary duct carcinoma (low-grade cribriform cystadenocarcinoma), oncocytic carcinoma, and adenocarcinoma not otherwise specified. Few tumors (clear cell carcinoma and basal cell adenocarcinoma) have unique molecular correlates...
December 2011: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26837790/common-malignant-salivary-gland-epithelial-tumors
#6
Raja R Seethala, E Leon Barnes
Malignant salivary gland epithelial tumors are histologically diverse with at least 24 recognized distinct entities. In general, malignant tumors account for 15% to 30% of parotid tumors, 40% to 45% of submandibular tumors, 70% to 90% of sublingual tumors, and 50% of minor salivary tumors. Common malignancies include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, salivary duct carcinoma, carcinoma ex pleomorphic adenoma, polymorphous lowgrade adenocarcinoma, and myoepithelial carcinoma...
December 2011: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26411881/ciliated-adenosquamous-carcinoma-expanding-the-phenotypic-diversity-of-human-papillomavirus-associated-tumors
#7
Lisa Radkay-Gonzalez, William Faquin, Jonathan B McHugh, James S Lewis, Madalina Tuluc, Raja R Seethala
This study describes a unique subset of ciliated, human papillomavirus (HPV) related, adenosquamous carcinomas (AsqCA) of the head and neck that in contrast to most AsqCA, often show areas with lower grade cytonuclear features. They are comprised of largely non-keratinizing squamous cell carcinoma components with cystic change, gland formation, mucin production, and cilia in tumor cells. Seven cases of ciliated AsqCA were retrieved. Site distribution was as follows: palatine tonsil--3/7, base of tongue--1/7, and neck (unknown primary site)--3/7...
June 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/26230372/comparison-of-p63-and-p40-%C3%AE-np63-as-basal-squamoid-and-myoepithelial-markers-in-salivary-gland-tumors
#8
Adepitan A Owosho, Cristina E Aguilar, Raja R Seethala
p40 is selective for ΔNp63 isoforms and appears to be more specific for squamous differentiation than p63. Its performance as a basal/myoepithelial marker in salivary gland tumors has only rarely been addressed in the literature. We thus compared the performance of p63 and p40 (ΔNp63) immunohistochemical stain as markers of basal, squamoid, and myoepithelial differentiation in 105 salivary gland tumors selected from our archives. The neoplasms were categorized according to their presumed phenotype as ductoacinar (n=45), biphasic (dual ductal and myoepithelial/basal differentiation, n=44), purely myoepithelial (n=5), and excretory duct phenotype (n=11)...
August 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/25972326/salivary-gland-tumor-fine-needle-aspiration-cytology-a-proposal-for-a-risk-stratification-classification
#9
Christopher C Griffith, Reetesh K Pai, Frank Schneider, Umamaheswar Duvvuri, Robert L Ferris, Jonas T Johnson, Raja R Seethala
OBJECTIVES: Fine-needle aspiration (FNA) is useful in the evaluation of salivary gland tumors, but currently no standard terminology or risk stratification model exists. METHODS: FNA smears were reviewed and categorized based on cytonuclear features, stromal characteristics, and background characteristics. Risk of malignancy was calculated for each category. Classifications as benign, neoplasm of uncertain malignant potential (NUMP), suspicious for malignancy, and positive for malignancy were used to aggregate categories into similar risk groups...
June 2015: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/25871467/salivary-duct-carcinoma-the-predominance-of-apocrine-morphology-prevalence-of-histologic-variants-and-androgen-receptor-expression
#10
MULTICENTER STUDY
Lindsay Williams, Lester D R Thompson, Raja R Seethala, Ilan Weinreb, Adel M Assaad, Madalina Tuluc, Nasir Ud Din, Bibianna Purgina, Chi Lai, Christopher C Griffith, Simion I Chiosea
Salivary duct carcinoma (SDC) is a prototypic aggressive salivary gland carcinoma. Our aim is to determine the prevalence of histologic variants (micropapillary, basal-like) and androgen receptor (AR) expression in a large multi-institutional series of SDC. AR status was determined by immunohistochemistry (IHC). Most SDCs were characterized by an apocrine phenotype and AR expression. Cases with a nonapocrine phenotype and AR-negative status were studied by additional IHC and fluorescence in situ hybridization for ETV6 or MYB/NFIB...
May 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/25723113/molecular-characterization-of-apocrine-salivary-duct-carcinoma
#11
Simion I Chiosea, Lindsay Williams, Christopher C Griffith, Lester D R Thompson, Ilan Weinreb, Julie E Bauman, Alyssa Luvison, Somak Roy, Raja R Seethala, Marina N Nikiforova
Contemporary classification and treatment of salivary duct carcinoma (SDC) require its thorough molecular characterization. Thirty apocrine SDCs were analyzed by the Ion Ampliseq Cancer HotSpot panel v2 for mutations in 50 cancer-related genes. Mutational findings were corroborated by immunohistochemistry (eg, TP53, BRAF, β-catenin, estrogen, and androgen receptors) or Sanger sequencing/SNaPshot polymerase chain reaction. ERBB2 (HER2), PTEN, FGFR1, CDKN2A/P16, CMET, EGFR, MDM2, and PIK3CA copy number changes were studied by fluorescence in situ hybridization...
June 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/25674280/mammary-analog-secretory-carcinoma-of-salivary-gland-with-high-grade-histology-arising-in-hard-palate-report-of-a-case-and-review-of-literature
#12
REVIEW
Wenyi Luo, Sarah W Lindley, Peter H Lindley, Gregory A Krempl, Raja R Seethala, Kar-Ming Fung
Mammary gland analog secretary carcinoma (MASC) of salivary gland is typically a tumor of low histologic grade and behaves as a low-grade malignancy with relatively benign course. This tumor shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, ETV6-NTRK3, with secretory carcinoma of breast. Histologically, it is often mistaken as acinic cell carcinoma, adenocarcinoma not otherwise specified, and other primary salivary gland tumors. Here we report a case of MASC with high-grade transformation and cervical lymph node metastases confirmed with ETV6-NTRK3 translocation arising in the hard palate of a 41 year-old adult...
2014: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/25497834/a-comparative-analysis-of-lef-1-in-odontogenic-and-salivary-tumors
#13
COMPARATIVE STUDY
Elizabeth A Bilodeau, Marie Acquafondata, E Leon Barnes, Raja R Seethala
LEF-1 is a nuclear transcription factor of the Wnt pathway that regulates multipotent skin stem cell differentiation. β-Catenin is considered a transcriptional coactivator that interacts with LEF-1.This study evaluates LEF-1 in a variety of odontogenic and salivary tumors and determines the prevalence of β-catenin coexpression. Ninety-eight salivary gland tumors and 51 odontogenic tumors were evaluated for LEF-1 and β-catenin immunohistochemical staining. Positivity was defined as at least 2+ intensity in more than 50% of tumor cells, which required a composite score of 6 or more...
February 2015: Human Pathology
https://www.readbyqxmd.com/read/25240283/hotspot-activating-prkd1-somatic-mutations-in-polymorphous-low-grade-adenocarcinomas-of-the-salivary-glands
#14
Ilan Weinreb, Salvatore Piscuoglio, Luciano G Martelotto, Daryl Waggott, Charlotte K Y Ng, Bayardo Perez-Ordonez, Nicholas J Harding, Javier Alfaro, Kenneth C Chu, Agnes Viale, Nicola Fusco, Arnaud da Cruz Paula, Caterina Marchio, Rita A Sakr, Raymond Lim, Lester D R Thompson, Simion I Chiosea, Raja R Seethala, Alena Skalova, Edward B Stelow, Isabel Fonseca, Adel Assaad, Christine How, Jianxin Wang, Richard de Borja, Michelle Chan-Seng-Yue, Christopher J Howlett, Anthony C Nichols, Y Hannah Wen, Nora Katabi, Nicholas Buchner, Laura Mullen, Thomas Kislinger, Bradly G Wouters, Fei-Fei Liu, Larry Norton, John D McPherson, Brian P Rubin, Blaise A Clarke, Britta Weigelt, Paul C Boutros, Jorge S Reis-Filho
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
November 2014: Nature Genetics
https://www.readbyqxmd.com/read/25141970/canalicular-adenoma-a-clinicopathologic-and-immunohistochemical-analysis-of-67-cases-with-a-review-of-the-literature
#15
REVIEW
Lester D R Thompson, Justin L Bauer, Simion Chiosea, Jonathan B McHugh, Raja R Seethala, Markku Miettinen, Susan Müller
There is a lack of a comprehensive immunohistochemical (IHC) analysis of canalicular adenoma (CanAd), especially when combined with a description of the unique histologic features. Given the usual small biopsies, IHC may be useful in distinguishing CanAd from other tumors in the differential diagnosis. Retrospective. The patients included 54 females and 13 males (4.2:1), aged 43-90 years, with a mean age at presentation of 69.9 years. Clinical presentation was generally a mass (n = 61) slowly increasing in size (mean 38...
June 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/25081914/adamantinoma-like-ewing-sarcoma-mimicking-basal-cell-adenocarcinoma-of-the-parotid-gland-a-case-report-and-review-of-the-literature
#16
REVIEW
Cecilia Lezcano, Martha R Clarke, Lei Zhang, Cristina R Antonescu, Raja R Seethala
Adamantinoma-like Ewing sarcoma (AES) is a rare variant of the Ewing family of tumors that resembles classic adamantinoma of bone. AES shows epithelial differentiation and a more complex immunohistochemical expression profile with keratin and basal marker immunoreactivity and can resemble a variety of carcinomas. We report an unusual case of an AES of the parotid gland that mimicked a basal cell adenocarcinoma. Like basal cell adenocarcinoma, this AES showed a nested basaloid proliferation with peripheral palisading in tumor nests with 'basaloid' epithelial differentiation as highlighted by cytokeratin AE1/3 and p40 positivity...
June 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/24942367/novel-prkd-gene-rearrangements-and-variant-fusions-in-cribriform-adenocarcinoma-of-salivary-gland-origin
#17
Ilan Weinreb, Lei Zhang, Laxmi M S Tirunagari, Yun-Shao Sung, Chun-Liang Chen, Bayardo Perez-Ordonez, Blaise A Clarke, Alena Skalova, Simion I Chiosea, Raja R Seethala, Daryl Waggott, Paul C Boutros, Christine How, Fei-Fei Liu, Jonathan C Irish, David P Goldstein, Ralph Gilbert, Nasir Ud Din, Adel Assaad, Jason L Hornick, Lester D R Thompson, Cristina R Antonescu
Polymorphous low-grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low-grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants of one spectrum, as they appear to have significant overlap, but also clinicopathologic differences. As many salivary carcinomas harbor recurrent translocations, paired-end RNA sequencing and FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs and two PLGAs...
October 2014: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/24804831/salivary-duct-carcinoma-and-the-concept-of-early-carcinoma-ex-pleomorphic-adenoma
#18
Christopher C Griffith, Lester D R Thompson, Adel Assaad, Bibianna M Purgina, Chi Lai, Julie E Bauman, Ilan Weinreb, Raja R Seethala, Simion I Chiosea
AIMS: The data on the histological type of carcinomatous component and the extent of extracapsular invasion for salivary carcinomas ex pleomorphic adenoma (PA) are conflicting. We aimed to determine the prognostic value of extracapsular invasion in salivary duct carcinomas (SDC) ex PA. METHODS AND RESULTS: A total of 117 patients with SDC were identified retrospectively; 44 cases involving major salivary glands had pre-existing PA (44 of 117, 37%). The morphological spectrum of SDC ex PA was characterized...
December 2014: Histopathology
https://www.readbyqxmd.com/read/24710732/sclerosing-rhabdomyosarcoma-presentation-of-a-rare-sarcoma-mimicking-myoepithelial-carcinoma-of-the-parotid-gland-and-review-of-the-literature
#19
REVIEW
Blake M Warner, Christopher C Griffith, William D Taylor, Raja R Seethala
Sclerosing rhabdomyosarcoma (SRMS), a recently characterized variant of rhabdomyosarcoma, can pose a significant diagnostic challenge given its rarity and its histological similarity to other malignancies. SRMS is characterized by dense hyalinized or sclerosing collagenous matrix and a pseudovascular pattern of growth. SRMS shares histologic similarities with several mesenchymal tumors including: leiomyosarcoma, osteosarcoma, chondrosarcoma, angiosarcoma, and sclerosing epithelioid fibrosarcoma. We herein report a case of SRMS mimicking a myoepithelial carcinoma of the parotid gland...
March 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/24446021/secretory-myoepithelial-carcinoma-a-histologic-and-molecular-survey-and-a-proposed-nomenclature-for-mucin-producing-signet-ring-tumors
#20
Jassem M Bastaki, Bibianna M Purgina, Sanja Dacic, Raja R Seethala
Signet ring cell (mucin producing) adenocarcinoma is a rare low grade salivary gland malignancy. While currently designated as an adenocarcinoma, myoepithelial differentiation has been implied in previously reported cases. We herein perform a survey of our cases of signet ring cell adenocarcinoma and review the literature in order to refine categorization of this rare tumor. Five cases were retrieved. One was reclassified as a mammary analogue secretory carcinoma, leaving four that fulfilled the criteria for signet ring cell adenocarcinoma: the presence of prominent signet ring or vacuolated cells arranged in islands, interconnecting strands, cords or sheets in a myxoid or hyaline stroma, or pools of mucin...
2014: Head and Neck Pathology
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