Bin Xu, Andrea L Barbieri, Justin A Bishop, Simon I Chiosea, Snjezana Dogan, Silvana Di Palma, William C Faquin, Ronald Ghossein, Martin Hyrcza, Vickie Y Jo, James S Lewis, John R Lozada, Michal Michal, Fresia G Pareja, Bayardo Perez-Ordonez, Manju L Prasad, Bibianna Purgina, Jorge S Reis-Filho, Theresa Scognamiglio, Ana P M Sebastiao, Raja R Seethala, Alena Skálová, Stephen M Smith, Merva S Tekkeşin, Lester D R Thompson, Jason K Wasseman, Bruce M Wenig, Ilan Weinreb, Nora Katabi
Polymorphous adenocarcinoma (PAC) shows histologic diversity with streaming and targetoid features whereas cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominantly cribriform and solid patterns with glomeruloid structures and optically clear nuclei. Opinions diverge on whether CASG represents a separate entity or a variant of PAC. We aimed to assess the level of agreement among 25 expert Head and Neck pathologists in classifying these tumors. Digital slides of 48 cases were reviewed and classified as: PAC, CASG, tumors with ≥50% of papillary architecture (PAP), and tumors with indeterminate features (IND)...
April 2020: American Journal of Surgical Pathology