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https://www.readbyqxmd.com/read/28749624/synthesis-characterization-and-evaluation-of-cytotoxic-effects-of-novel-hybrid-steroidal-heterocycles-as-peg-based-nanoparticles
#1
Mervat M Abd Elhalim, Nasser S M Ismail, Shaymaa M M Yahya, Yasmin Y Omar, Ahmed A Abd Rabou, Deena S Lasheen, Mahmoud F Zawrah, Gamal A Elmegeed
Anticancer agents featuring hybrid molecules can improve effectiveness and diminish drug resistance. The current study aimed to introduce newly synthesized heterocyclic steroids of promising anticancer effects loaded in polyethylene glycol (PEG)•based nanoparticles form. Several heterocyclic steroids (1-9) were synthesized via multicomponent reactions (MCRs) and confirmed via the analytical and spectral data. Compounds 1, 2, 3, 4, 5, 6, 7 and 9, were investigated individually in their free and PEG based nano-size hybrid forms as anticancer agents against three human cell lines: hepatocellular carcinoma cells (HepG2); breast cancer cells (MCF-7); and colon cancer cells (HCT116)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749466/knockout-of-march2-inhibits-the-growth-of-hct116-colon-cancer-cells-by-inducing-endoplasmic-reticulum-stress
#2
Dan Xia, Wanli Ji, Chentong Xu, Xin Lin, Xiaokun Wang, Yan Xia, Ping Lv, Quansheng Song, Dalong Ma, Yingyu Chen
Membrane-associated RING-CH protein 2 (MARCH2), a member of the MARCH family, functions in vesicle trafficking and autophagy regulation. In this study, we established MARCH2 knockout HCT116 cell lines using CRISPR/Cas9-mediated genome editing to evaluate the role of MARCH2 in colon cancer in vitro and in vivo. Knockout of MARCH2 suppressed cell proliferation, and promoted autophagy, apoptosis and G2/M phase cell cycle arrest. These effects were associated with activation of endoplasmic reticulum (ER) stress...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28749261/colonic-adenocarcinomas-in-a-familial-group-of-captive-amur-rat-snakes-elaphe-schrencki
#3
Benjamin Lamglait, Karin Lemberger
This article reports five cases of colonic adenocarcinomas in a family group of captive Amur rat snake (Elaphe schrenckii) from the Réserve Africaine de Sigean, France. This tumor was detected in three females and two males, all adults, and accounted for 16% of causes of death of adults of this species at this institution from 1986 to 2013. Grossly, mild to marked thickening of the intestinal wall cranially to the cloaca was found in four cases; tan to yellow firm masses were noted in the distal intestinal wall in the other case...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749188/enteric-coatings-for-colonic-drug-delivery-state-of-the-art
#4
Alessandra Maroni, Saliha Moutaharrik, Lucia Zema, Andrea Gazzaniga
No abstract text is available yet for this article.
July 27, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28748988/-characterization-of-patients-with-sporadic-colorectal-cancer-following-the-new-consensus-molecular-subtypes-cms
#5
Ana María Wielandt, Cynthia Villarroel, Claudia Hurtado, Daniela Simian, Diego Zamorano, Maripaz Martínez, Magdalena Castro, María Teresa Vial, Udo Kronberg, Francisco López-Kostner
BACKGROUND: Colorectal cancer (CRC) is an heterogeneous disease. Three carcinogenic pathways determine its molecular profile: microsatellite instability (MSI), chromosomal instability (CIN) and CpG island methylator phenotype (CIMP). Based on the new molecular classification, four consensus CRC molecular subtypes (CMS) are established, which are related to clinical, pathological and biological characteristics of the tumor. AIM: To classify Chilean patients with sporadic CRC according to the new consensus molecular subtypes of carcinogenic pathways...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748664/long-term-efficient-control-of-siv-infection-in-macaques-is-associated-with-an-intact-intestinal-barrier
#6
Maria Daskalaki, Berit Neumann, Antonina Klippert, Kerstin Mätz-Rensing, Franz-Josef Kaup, Christiane Stahl-Hennig
Hallmarks of SIV infection are early depletion of gut CD4 T cells and diminished intestinal integrity. Comprehensive studies on colon biopsies of SIV-infected macaques efficiently controlling infection revealed that in contrast to viremic and failing controllers, elite controllers show preserved CD4 T cells, and low viral load, apoptosis, and inflammation.
August 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28748628/reproductive-phenology-of-creole-horses-in-ecuador-in-the-absence-of-photoperiod-variation-the-effects-of-forage-availability-and-flooding-affecting-body-condition-of-mares
#7
Juan Carranza, Washington A Yoong, Concha Mateos, Belén Caño Vergara, Chian L Gómez, Verónica Macías
Horse reproduction tends to be seasonal. The main adjusting factor in their original temperate ranges is photoperiod variation, although it is absent in equatorial areas where horses were introduced by European colonizers. Hence, dates of reproduction in these areas may be influenced by factors affecting mares' conditions and the success of foaling. Here we study reproductive timing in Creole horses in Ecuador reared in an extensive production system. We found that foaling peaked in August. Mares' conditions showed one peak in June-July, before the start of the breeding season, and another in December, and it was highly variable along the year...
July 27, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28748436/organophosphorus-pesticide-mixture-removal-from-environmental-matrices-by-a-soil-streptomyces-mixed-culture
#8
Gabriela Briceño, Karen Vergara, Heidi Schalchli, Graciela Palma, Gonzalo Tortella, María Soledad Fuentes, María Cristina Diez
The current study aimed to evaluate the removal of a pesticide mixture composed of the insecticides chlorpyrifos (CP) and diazinon (DZ) from liquid medium, soil and a biobed biomixture by a Streptomyces mixed culture. Liquid medium contaminated with 100 mg L(-1) CP plus DZ was inoculated with the Streptomyces mixed culture. Results indicated that microorganisms increased their biomass and that the inoculum was viable. The inoculum was able to remove the pesticide mixture with a removal rate of 0.036 and 0...
July 26, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28748345/educational-inequality-in-cancer-mortality-a-record-linkage-study-of-over-35-million-italians
#9
Gianfranco Alicandro, Luisa Frova, Gabriella Sebastiani, Iman El Sayed, Paolo Boffetta, Carlo La Vecchia
PURPOSE: Large studies are needed to evaluate socioeconomic inequality for site-specific cancer mortality. We conducted a longitudinal census-based national study to quantify the relative inequality in cancer mortality among educational levels in Italy. METHODS: We linked the 2011 Italian census with the 2012 and 2013 death registries. Educational inequality in overall cancer and site-specific cancer mortality were evaluated by computing the mortality rate ratio (MRR)...
July 26, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28748288/talaromyces-sayulitensis-acidiella-bohemica-and-penicillium-citrinum-in-brazilian-oil-shale-by-products
#10
Kelly C G P de Goes, Josué J da Silva, Gisele M Lovato, Beatriz T Iamanaka, Fernanda P Massi, Diva S Andrade
Fine shale particles and retorted shale are waste products generated during the oil shale retorting process. These by-products are small fragments of mined shale rock, are high in silicon and also contain organic matter, micronutrients, hydrocarbons and other elements. The aims of this study were to isolate and to evaluate fungal diversity present in fine shale particles and retorted shale samples collected at the Schist Industrialization Business Unit (Six)-Petrobras in São Mateus do Sul, State of Paraná, Brazil...
July 26, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28748285/toward-the-standardization-of-mycological-examination-of-sputum-samples-in-cystic-fibrosis-results-from-a-french-multicenter-prospective-study
#11
Noémie Coron, Marc Pihet, Emilie Fréalle, Yolande Lemeille, Claudine Pinel, Hervé Pelloux, Gilles Gargala, Loic Favennec, Isabelle Accoceberry, Isabelle Durand-Joly, Frédéric Dalle, Frédéric Huet, Annlyse Fanton, Amale Boldron, Guy-André Loeuille, Philippe Domblides, Bérengère Coltey, Isabelle Pin, Catherine Llerena, Françoise Troussier, Christine Person, Christophe Marguet, Nathalie Wizla, Caroline Thumerelle, Dominique Turck, Stéphanie Bui, Michael Fayon, Alain Duhamel, Anne Prévotat, Benoit Wallaert, Sylvie Leroy, Jean-Philippe Bouchara, Laurence Delhaes
Fungal respiratory colonization of cystic fibrosis (CF) patients emerges as a new concern; however, the heterogeneity of mycological protocols limits investigations. We first aimed at setting up an efficient standardized protocol for mycological analysis of CF sputa that was assessed during a prospective, multicenter study: "MucoFong" program (PHRC-06/1902). Sputa from 243 CF patients from seven centers in France were collected over a 15-month period and submitted to a standardized protocol based on 6 semi-selective media...
July 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28748258/ezh2-is-involved-in-silencing-of-wnt5a-during-epithelial-mesenchymal-transition-of-colon-cancer-cell-line
#12
Jianxin Tao, Liping Shi, Longchang Huang, Haoze Shi, Hang Chen, Yixin Wang, Tong Wang
PURPOSE: Transforming growth factor-β (TGF-β) induction of epithelial-mesenchymal transition (EMT) in SW480 was established as a system for studies of colon cancer metastasis. However, the epigenetic mechanisms underlying this process remain unknown. In mammal, polycomb repressive complex-2 (PRC2) is a highly conserved histone methyltransferase involved in epigenetic regulations. Enhancer of zeste Homolog 2 (EZH2) is the catalytic subunit of PRC2, which catalyzes methylation of lysine 27 of histone H3 (H3K27)...
July 26, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28748213/metabolic-reprogramming-underlies-metastatic-potential-in-an-obesity-responsive-murine-model-of-metastatic-triple-negative-breast-cancer
#13
Ciara H O'Flanagan, Emily L Rossi, Shannon B McDonell, Xuewen Chen, Yi-Hsuan Tsai, Joel S Parker, Jerry Usary, Charles M Perou, Stephen D Hursting
The vast majority of cancer-related deaths are due to metastatic disease, whereby primary tumor cells disseminate and colonize distal sites within the body. Triple negative breast cancer typically displays aberrant Wnt signaling, lacks effective targeted therapies, and compared with other breast cancer subtypes, is more likely to recur and metastasize. We developed a Wnt-driven lung metastasis model of triple negative breast cancer (metM-Wnt(lung)) through serial passaging of our previously described, nonmetastatic, claudin-low M-Wnt cell line...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28748208/dataset-of-sgo1-expression-in-cardiac-gastrointestinal-hepatic-and-neuronal-tissue-in-mouse
#14
Andrew T Song, Antonella Galli, Severine Leclerc, Stanley Nattel, Craig Mandato, Gregor Andelfinger
The data shown in this article are related to the research article entitled "Characterization of Sgo1 expression pattern in developing and adult mouse" (Song et al., 2017) [3]. The article provides novel data on Sgo1 gene expression pattern utilizing Sgo1_LacZ_Knock in mouse line and immunohistochemistry in wild type mice. The data presents Sgo1 expression pattern during development, and in post-developmental proliferative and quiescent tissue. The article describes following tissues: developing heart, neural tube, adult colon, cerebellum, cerebral cortex, liver, and testis...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28748100/a-case-of-hypercalcaemia-in-an-immunocompetent-patient-with-mycobacterium-avium-intracellulare
#15
Christine E Parsons, Sujata Singh, Holly L Geyer
Mycobacterium avium intracellulare infection or colonization should be considered in the differential diagnosis of hypercalcemia, especially in immunocompromised individuals, in the appropriate clinical context.
July 2017: JRSM Open
https://www.readbyqxmd.com/read/28748042/porphyromonas-gingivalis-disturbs-host-commensal-homeostasis-by-changing-complement-function
#16
REVIEW
Ingar Olsen, John D Lambris, George Hajishengallis
Porphyromonas gingivalis is a Gram-negative anaerobic rod that has been proposed as an orchestrator of complement-dependent dysbiotic inflammation. This notion was suggested from its capacities to manipulate the complement-Toll-like receptor crosstalk in ways that promote dysbiosis and periodontal disease in animal models. Specifically, while at low colonization levels, P. gingivalis interferes with innate immunity and leads to changes in the counts and composition of the oral commensal microbiota. The resulting dysbiotic microbial community causes disruption of host-microbial homeostasis, leading to inflammatory bone loss...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28748040/effect-of-erythritol-on-microbial-ecology-of-in-vitro-gingivitis-biofilms
#17
Marleen Marga Janus, Catherine Minke Charlotte Volgenant, Bernd Willem Brandt, Mark Johannes Buijs, Bart Jan Frederik Keijser, Wim Crielaard, Egija Zaura, Bastiaan Philip Krom
Gingivitis is one of the most common oral infections in humans. While sugar alcohols such as erythritol are suggested to have caries-preventive properties, it may also have beneficial effects in prevention of gingivitis by preventing maturation of oral biofilms. The aim of this study was to assess the effect of erythritol on the microbial ecology and the gingivitis phenotype of oral microcosms. Biofilms were inoculated with stimulated saliva from 20 healthy donors and grown in a gingivitis model in the continuous presence of 0 (control group), 5, and 10% erythritol...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28748029/prevalence-of-and-risk-factors-for-methicillin-resistant-staphylococcus-aureus-colonization-among-human-immunodeficient-virus-infected-outpatients-in-taiwan-oral-candida-colonization-as-a-comparator
#18
Chi-Jung Wu, Wen-Chien Ko, Mao-Wang Ho, Hsi-Hsun Lin, Yun-Liang Yang, Jiun-Nong Lin, I-Wen Huang, Hui-Ying Wang, Jui-Fen Lai, Yih-Ru Shiau, Li-Yun Hsieh, Hui-Ting Chen, Chih-Chao Lin, Wen-Li Chu, Hsiu-Jung Lo, Tsai-Ling Lauderdale
Human immuodeficency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) and community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) have increased in recent years in Taiwan. This study was undertaken to determine the prevalence of and risk factors for nasal and oral S. aureus and MRSA colonization among contemporary HIV-infected populations. Clinical variables for S. aureus and MRSA colonization among HIV-infected outpatients from three hospitals were analyzed and compared with those for oral Candida colonization...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28748028/porphyromonas-gingivalis-suppresses-invasion-of-fusobacterium-nucleatum-into-gingival-epithelial-cells
#19
Young-Jung Jung, Hye-Kyoung Jun, Bong-Kyu Choi
Invasion of periodontal pathogens into periodontal tissues is an important step that can cause tissue destruction in periodontal diseases. Porphyromonas gingivalis is a keystone pathogen and its gingipains are key virulence factors. Fusobacterium nucleatum is a bridge organism that mediates coadhesion of disease-causing late colonizers such as P. gingivalis and early colonizers during the development of dental biofilms. The aim of this study was to investigate how P. gingivalis, in particular its gingipains, influences the invasion of coinfecting F...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28748027/oral-candidiasis-among-african-human-immunodeficiency-virus-infected-individuals-10-years-of-systematic-review-and-meta-analysis-from-sub-saharan-africa
#20
REVIEW
Martha F Mushi, Oliver Bader, Liliane Taverne-Ghadwal, Christine Bii, Uwe Groß, Stephen E Mshana
Oral candidiasis (OC) is the most common opportunistic fungal infection among immunocompromised individuals. This systematic review and meta-analysis reports on the contribution of non-albicans Candida species in causing OC among human immunodeficiency virus (HIV)-infected individuals in sub-Saharan Africa between 2005 and 2015. Thirteen original research articles on oral Candida infection/colonization among HIV-infected African populations were reviewed. The prevalence of OC ranged from 7.6% to 75.3%. Pseudomembranous candidiasis was found to range from 12...
2017: Journal of Oral Microbiology
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