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https://www.readbyqxmd.com/read/28821155/simultaneous-influence-of-pectin-and-xyloglucan-on-structure-and-mechanical-properties-of-bacterial-cellulose-composites
#1
Monika Szymańska-Chargot, Monika Chylińska, Justyna Cybulska, Arkadiusz Kozioł, Piotr M Pieczywek, Artur Zdunek
The impact of the matrix polysaccharides on the cellulose microfibrils structure as well as on the mechanical properties of cell walls still remains an open question. Therefore, the aim of investigations was to determine the simultaneous influence of (i) different concentrations of pectins with constant concentration of xyloglucan, and (ii) different concentrations of xyloglucan with constant concentration of pectins on cellulose structure. Composites of bacterial cellulose (BC) produced by Komagataeibacter xylinus are considered to mimic natural plant cell walls...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821149/solution-blow-spun-nanocomposites-of-poly-lactic-acid-cellulose-nanocrystals-from-eucalyptus-kraft-pulp
#2
Delne Domingos da Silva Parize, Juliano Elvis de Oliveira, Tina Williams, Delilah Wood, Roberto de Jesús Avena-Bustillos, Artur Piotr Klamczynski, Gregory Melvin Glenn, José Manoel Marconcini, Luiz Henrique Capparelli Mattoso
Cellulose nanocrystals (CNCs) were extracted from Eucalyptus kraft pulp by sulfuric acid hydrolysis, and esterified with maleic anhydride (CNCMA). The incorporation of sulfate ester groups on the cellulose surface resulted in higher stability of the nanoparticles in aqueous suspensions and lower thermal stability. Then, PLA/CNC and PLA/CNCMA nanocomposites were successfully obtained by solution blow spinning (SBS) using dimethyl carbonate (DMC) as solvent. CNC and CNCMA indicated to be acting both as nucleating agents or growth inhibitors of PLA crystal and tends to favor the formation of PLA crystals of higher stability...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28819953/impact-of-post-dilatation-on-the-reduction-of-paravalvular-leak-and-mortality-after-transcatheter-aortic-valve-implantation
#3
Paweł Kleczyński, Artur Dziewierz, Marzena Daniec, Maciej Bagieński, Łukasz Rzeszutko, Danuta Sorysz, Jarosław Trębacz, Robert Sobczyński, Marek Tomala, Dariusz Dudek
BACKGROUND: Post-implantation paravalvular leak (PVL) remains a significant complication of transcatheter aortic valve implantation (TAVI). More importantly, its occurrence may impact long-term mortality. AIM: We sought to evaluate the effects of balloon post-dilatation (PD) on the reduction of PVL and mortality in patients undergoing TAVI. METHODS: A total of 101 consecutive patients undergoing TAVI were enrolled. Angiography, echocardiography, and the aortic regurgitation index (ARI) were used to assess the severity of PVL before and after balloon PD...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28818819/quantifying-human-movement-using-the-movn-smartphone-app-validation-and-field-study
#4
Ralph Maddison, Luke Gemming, Javier Monedero, Linda Bolger, Sarahjane Belton, Johann Issartel, Samantha Marsh, Artur Direito, Madeleine Solenhill, Jinfeng Zhao, Daniel John Exeter, Harshvardhan Vathsangam, Jonathan Charles Rawstorn
BACKGROUND: The use of embedded smartphone sensors offers opportunities to measure physical activity (PA) and human movement. Big data-which includes billions of digital traces-offers scientists a new lens to examine PA in fine-grained detail and allows us to track people's geocoded movement patterns to determine their interaction with the environment. OBJECTIVE: The objective of this study was to examine the validity of the Movn smartphone app (Moving Analytics) for collecting PA and human movement data...
August 17, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28818603/effects-of-suspended-sediments-and-nutrient-enrichment-on-juvenile-corals
#5
Adriana Humanes, Artur Fink, Bette L Willis, Katharina E Fabricius, Dirk de Beer, Andrew P Negri
Three to six-month-old juveniles of Acropora tenuis, A. millepora and Pocillopora acuta were experimentally co-exposed to nutrient enrichment and suspended sediments (without light attenuation or sediment deposition) for 40days. Suspended sediments reduced survivorship of A. millepora strongly, proportional to the sediment concentration, but not in A. tenuis or P. acuta juveniles. However, juvenile growth of the latter two species was reduced to less than half or to zero, respectively. Additionally, suspended sediments increased effective quantum yields of symbionts associated with A...
August 14, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28818461/discovery-and-process-development-of-a-novel-tace-inhibitor-for-the-topical-treatment-of-psoriasis
#6
Jean-Guy Boiteau, Gilles Ouvry, Jean-Marie Arlabosse, Stéphanie Astri, Audrey Beillard, Yushma Bhurruth-Alcor, Laetitia Bonnary, Claire Bouix-Peter, Karine Bouquet, Marilyne Bourotte, Isabelle Cardinaud, Catherine Comino, Benoît Deprez, Denis Duvert, Angélique Féret, Feriel Hacini-Rachinel, Craig S Harris, Anne-Pascale Luzy, Arnaud Mathieu, Corinne Millois, Nicolas Orsini, Jonathan Pascau, Artur Pinto, David Piwnica, Gaëlle Polge, Arnaud Reitz, Kevin Reversé, Nicolas Rodeville, Patricia Rossio, Delphine Spiesse, Samuel Tabet, Nathalie Taquet, Loïc Tomas, Emmanuel Vial, Laurent F Hennequin
Targeting the TNFα pathway is a validated approach to the treatment of psoriasis. In this pathway, TACE stands out as a druggable target and has been the focus of in-house research programs. In this article, we present the discovery of clinical candidate 26a. Starting from hits plagued with poor solubility or genotoxicity, 26a was identified through thorough multiparameter optimisation. Showing robust in vivo activity in an oxazolone-mediated inflammation model, the compound was selected for development. Following a polymorph screen, the hydrochloride salt was selected and the synthesis was efficiently developed to yield the API in 47% overall yield...
August 2, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28817543/plasma-levels-of-the-a-subunit-of-factor-xiii-in-patients-undergoing-off-pump-coronary-artery-bypass-surgery
#7
Artur Słomka, Piotr Korbal, Aleksandra Piekuś, Wojciech Pawliszak, Lech Anisimowicz, Ewa Żekanowska
No abstract text is available yet for this article.
August 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28817542/safety-of-transesophageal-echocardiography%C3%A2-guided-electrical-cardioversion-in-patients-with-atrial-fibrillation-and-inadequate-anticoagulation
#8
Joanna Zaprutko, Artur Baszko, Michał Michalak, Karol Kochman, Radosław Szymański, Jan Kłopocki, Anna Nowicka, Rafał Dankowski, Marek Michalski, Piotr Kałmucki, Andrzej Szyszka
INTRODUCTION    Restoring sinus rhythm in patients with atrial fibrillation (AF)/atrial flutter (AFl) requires adequate oral anticoagulation prior to direct current cardioversion (DCC). Some patients eligible for DCC are not properly anticoagulated. OBJECTIVES    The aim of the study was to assess risk factors for thrombus and spontaneous echo contrast (SEC) in the left atrium (LA) as well as the safety profile of transesophageal echocardiography (TEE)-guided DCC in patients with inadequate anticoagulation...
August 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28816159/consensus-guidelines-for-implementing-pencil-beam-scanning-proton-therapy-for-thoracic-malignancies-on-behalf-of-the-ptcog-thoracic-and-lymphoma-subcommittee
#9
REVIEW
Joe Y Chang, Xiaodong Zhang, Antje Knopf, Heng Li, Shinichiro Mori, Lei Dong, Hsiao-Ming Lu, Wei Liu, Shahed N Badiyan, Stephen Both, Arturs Meijers, Liyong Lin, Stella Flampouri, Zuofeng Li, Kikuo Umegaki, Charles B Simone, Xiaorong R Zhu
Pencil-beam scanning (PBS) proton therapy (PT), particularly intensity modulated PT, represents the latest advanced PT technology for treating cancers, including thoracic malignancies. On the basis of virtual clinical studies, PBS-PT appears to have great potential in its ability to tightly tailor the dose to the target while sparing critical structures, thereby reducing treatment-related toxicities, particularly for tumors in areas with complicated anatomy. However, implementing PBS-PT for moving targets has several additional technical challenges compared with intensity modulated photon radiation therapy or passive scattering PT...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28815589/tight-temporal-coupling-between-synaptic-rewiring-of-olfactory-glomeruli-and-the-emergence-of-odor-guided-behavior-in-xenopus-tadpoles
#10
Beatrice Terni, Paolo Pacciolla, Helena Masanas, Pau Gorostiza, Artur Llobet
Olfactory sensory neurons (OSNs) are chemoreceptors that establish excitatory synapses within glomeruli of the olfactory bulb. OSNs undergo continuous turnover throughout life, causing the constant replacement of their synaptic contacts. Using Xenopus tadpoles as an experimental system to investigate rewiring of glomerular connectivity, we show that novel OSN synapses can transfer information immediately after formation, mediating an olfactory-guided behavior. Tadpoles recover the ability to detect amino acids four days after bilateral olfactory nerve transection...
August 17, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28815031/capsule-retention-related-to-small-bowel-capsule-endoscopy-a-large-european-single-center-10-year-clinical-experience
#11
Artur Nemeth, Gabriele Wurm Johansson, Jörgen Nielsen, Henrik Thorlacius, Ervin Toth
BACKGROUND: The most concerning complication of video capsule endoscopy (VCE) is capsule retention (CR) in the gastrointestinal (GI) tract although clinical outcome and management of patients with CR are still uncertain in a large single center material. OBJECTIVES: The aim of this retrospective study was to investigate incidence, causes, risk factors, management and clinical outcomes of CR in a large single center between 2001 and 2011. RESULTS: 2401 consecutive small-bowel (SB) VCEs were performed...
August 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28813898/robots-testing-robots-alan-arm-a-humanoid-arm-for-the-testing-of-robotic-rehabilitation-systems
#12
Jack Brookes, Maksims Kuznecovs, Menelaos Kanakis, Arturs Grigals, Mazvydas Narvidas, Justin Gallagher, Martin Levesley
Robotics is increasing in popularity as a method of providing rich, personalized and cost-effective physiotherapy to individuals with some degree of upper limb paralysis, such as those who have suffered a stroke. These robotic rehabilitation systems are often high powered, and exoskeletal systems can attach to the person in a restrictive manner. Therefore, ensuring the mechanical safety of these devices before they come in contact with individuals is a priority. Additionally, rehabilitation systems may use novel sensor systems to measure current arm position...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813105/a-scientific-survey-on-1550-cases-of-oral-lesions-diagnosed-in-a-brazilian-referral-center
#13
Artur C Vasconcelos, Carlos Aburad, Igor F P Lima, Sheila M M Santos, Silas Antonio J DE Freitas, Ademir Franco, Sigmar M Rode, Luiz R Paranhos
The present study aimed to perform an epidemiological survey on the prevalence rate of oral lesions diagnosed in a referral center in Brazil and to establish association between the lesions and the age and gender of the affected patients. This analytical observational study analyzed 3521 medical records of anatomopathological exams of the Pathological Anatomy and Cytopathology Laboratory of the Cancer Hospital of the state of Mato Grosso (Brazil), from December 2011 to September 2015. A total of 1550 relevant medical records was detected...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28812063/self-organization-of-amino-acid-derived-ndi-assemblies-into-a-nanofibrillar-superstructure-with-humidity-sensitive-n-type-semiconducting-properties
#14
Marco A Squillaci, Grzegorz Markiewicz, Anna Walczak, Artur Ciesielski, Artur R Stefankiewicz, Paolo Samorì
The hierarchical self-assembly of l-tyrosine substituted naphthalenediimide has been explored in solution by NMR spectroscopy and in the solid-state by atomic force microscopy. Spontaneous non-covalent polymerisation led to the formation of a three-dimensional fibre-like supramolecular polymer with n-type semiconducting properties.
August 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28811596/complete-alanine-scanning-of-the-escherichia-coli-rbsb-ribose-binding-protein-reveals-residues-important-for-chemoreceptor-signaling-and-periplasmic-abundance
#15
Artur Reimer, Vitali Maffenbeier, Manupriyam Dubey, Vladimir Sentchilo, Diogo Tavares, Manuel Hernandez Gil, Siham Beggah, Jan Roelof van der Meer
The Escherichia coli RbsB ribose binding protein has been used as a scaffold for predicting new ligand binding functions through in silico modeling, yet with limited success and reproducibility. In order to possibly improve the success of predictive modeling on RbsB, we study here the influence of individual residues on RbsB-mediated signaling in a near complete library of alanine-substituted RbsB mutants. Among a total of 232 tested mutants, we found 10 which no longer activated GFPmut2 reporter expression in E...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811194/immunogenetic-studies-of-the-hepatitis-c-virus-infection-in-an-era-of-pan-genotype-antiviral-therapies-effective-treatment-is-coming
#16
Joel Henrique Ellwanger, Valéria de Lima Kaminski, Jacqueline Maria Valverde-Villegas, Daniel Simon, Vagner Ricardo Lunge, José Artur Bogo Chies
What are the factors that influence human hepatitis C virus (HCV) infection, hepatitis status establishment, and disease progression? Firstly, one has to consider the genetic background of the host and HCV genotypes. The immunogenetic host profile will reflect how each infected individual deals with infection. Secondly, there are environmental factors that drive susceptibility or resistance to certain viral strains. These will dictate (I) the susceptibility to infection; (II) whether or not an infected person will promote viral clearance; (III) the immune response and the response profile to therapy; and (IV) whether and how long it would take to the development of HCV-associated diseases, as well as their severity...
August 12, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28810773/geometric-phase-effects-in-excited-state-dynamics-through-a-conical-intersection-in-large-molecules-n-dimensional-linear-vibronic-coupling-model-study
#17
Jiaru Li, Loïc Joubert-Doriol, Artur F Izmaylov
We investigate geometric phase (GP) effects in nonadiabatic transitions through a conical intersection (CI) in an N-dimensional linear vibronic coupling (ND-LVC) model. This model allows for the coordinate transformation encompassing all nonadiabatic effects within a two-dimensional (2D) subsystem, while the other N - 2 dimensions form a system of uncoupled harmonic oscillators identical for both electronic states and coupled bi-linearly with the subsystem coordinates. The 2D subsystem governs ultra-fast nonadiabatic dynamics through the CI and provides a convenient model for studying GP effects...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810284/-development-of-non-arteritic-anterior-ischaemic-optic-neuropathy-in-the-initially-unaffected-fellow-eye-in-patients-treated-with-systemic-corticosteroids
#18
Artur Pahor, Dusica Pahor
Background The objective of this prospective pilot study was to evaluate the results of systemic corticosteroid therapy in patient with non-arteritic anterior ischaemic neuropathy of the optical nerve (NAION) for an observation period of one year and to measure the NAION incidence in the initially healthy contralateral eye of these patients. Patients and Methods All patients diagnosed with acute NAION who were admitted to our ward during 2014 and who fulfilled all inclusion criteria for systemic corticosteroid therapy were included in the study...
August 15, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28810061/single-dose-pharmacokinetics-of-co-crystal-of-tramadol-celecoxib-results-of-a-4-way-randomized-open-label-phase-i-clinical-trial-in-healthy-subjects
#19
Sebastián Videla, Mounia Lahjou, Anna Vaqué, Mariano Sust, Mercedes Encabo, Lluis Soler, Artur Sans, Eric Sicard, Neus Gascón, Gregorio Encina, Carlos Plata-Salamán
AIM: Co-Crystal of Tramadol-Celecoxib (CTC) is a novel co-crystal molecule containing two active pharmaceutical ingredients (APIs) under development by Esteve (E-58425) and Mundipharma Research (MR308). This Phase I study compared single-dose pharmacokinetics (PK) of CTC with those of the individual reference products (immediate-release [IR] tramadol and celecoxib) alone and in open combination. METHODS: Healthy adults aged 18-55 years were orally administered four treatments under fasted conditions (separated by 7-day wash-out period): 200 mg IR CTC (equivalent to 88 mg tramadol and 112 mg celecoxib; Treatment-1); 100 mg IR tramadol (Treatment-2); 100 mg celecoxib (Treatment-3); and 100 mg IR tramadol and 100 mg celecoxib (Treatment-4)...
August 15, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28809462/multiple-electronic-and-structural-factors-control-cpd-and-6-4-thymine-thymine-photodimerization-in-dna-duplex
#20
Irene Conti, Lara Martinez Fernandez, Luciana Esposito, Siegfried Hofinger, Artur Nenov, Marco Garavelli, Roberto Improta
The T-T photodimerization paths leading to the formation of cyclobutane pyrimidine dimer (CPD) and 6-4 pyrimidine pyrimidone (64-PP), the two main DNA photolesions, have been resolved for a T-T step in a DNA duplex by two complementary state-of-the art quantum mechanical approaches: QM(CASPT2//CASSCF)/MM and TD-DFT/PCM. Based on the analysis of several different representative structures, we define a new-ensemble of cooperating geometrical and electronic factors (besides the distance between the reacting bonds) ruling T-T photodimerization in DNA...
August 15, 2017: Chemistry: a European Journal
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