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https://www.readbyqxmd.com/read/29793081/geochemical-anomalies-of-trace-elements-in-unremediated-soils-of-mt-karcz%C3%A3-wka-a-historic-lead-mining-area-in-the-city-of-kielce-poland
#1
Agnieszka Gałuszka, Zdzisław M Migaszewski, Sabina Dołęgowska, Artur Michalik
Concentrations of selected trace elements (Ag, As, Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Zn) and rare earth elements were determined in 61 samples of surface soils collected from Mt. Karczówka, a historic Pb ore mining area located in the city of Kielce, south-central Poland. Some of these samples were subjected to XRD analyses and Pb stable isotope measurements. The mineral and chemical composition of rock samples were also examined. Mining activity in the study area was conducted mostly during 15th-17th centuries using technologically primitive methods, and was finally ceased in the first half of the 19th century...
May 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29792193/research-ethics-review-at-university-eduardo-mondlane-uem-maputo-central-hospital-mozambique-2013-2016-a-descriptive-analysis-of-the-start-up-of-a-new-research-ethics-committee-rec
#2
Jahit Sacarlal, Vasco Muchanga, Carlos Mabutana, Matilde Mabui, Arlete Mariamo, Assa Júlio Cuamba, Leida Artur Fumo, Jacinta Silveira, Elizabeth Heitman, Troy D Moon
BACKGROUND: Mozambique has seen remarkable growth in biomedical research over the last decade. To meet a growing need, the National Committee for Bioethics in Health of Mozambique (CNBS) encouraged the development of ethical review processes at institutions that regularly conduct medical and social science research. In 2012, the Faculty of Medicine (FM) of University Eduardo Mondlane (UEM) and the Maputo Central Hospital (MCH) established a joint Institutional Committee on Bioethics for Health (CIBS FM & MCH)...
May 23, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29791187/a-single-lab-test-to-aid-pierre-robin-sequence-severity-diagnosis
#3
Artur Fahradyan, Beina Azadgoli, Michaela Tsuha, Mark M Urata, Stacey H Francis
OBJECTIVE: The workup of patients with Pierre Robin sequence (PRS) consists of a physical examination, O2 saturation, and polysomnography to determine the severity of respiratory obstruction and need for surgery. We suggest that capillary blood gas (CBG) may be a better physiologic representation of airway obstruction and should be routinely used in the management of patients with PRS. DESIGN: This is a multicenter study based on a retrospective review of medical records...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29791163/on-the-relationship-between-excited-state-lifetime-and-isomerization-quantum-yield-in-animal-rhodopsins-beyond-the-one-dimensional-landau-zener-model
#4
Mohsen M T El-Tahawy, Artur Nenov, Oliver Weingart, Massimo Olivucci, Marco Garavelli
We show that the speed of the chromophore photoisomerization of animal rhodopsins is not a relevant control knob for their light sensitivity. This result is at odd with the momentum-driven tunnelling rationale (i.e., assuming a one-dimensional Landau-Zener model for the decay: Zener, C. "Non-Adiabatic Crossing of Energy Levels", Proceedings of the Royal Society of London. Series A 1932, 137 (833), 696-702) holding that a faster nuclear motion through the conical intersection translates into a higher quantum yield and, thus, light sensitivity...
May 23, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29789554/synthetic-cytokine-receptors-transmit-biological-signals-using-artificial-ligands
#5
Erika Engelowski, Artur Schneider, Manuel Franke, Haifeng Xu, Ramona Clemen, Alexander Lang, Paul Baran, Christian Binsch, Birgit Knebel, Hadi Al-Hasani, Jens M Moll, Doreen M Floß, Philipp A Lang, Jürgen Scheller
Cytokine-induced signal transduction is executed by natural biological switches, which among many others control immune-related processes. Here, we show that synthetic cytokine receptors (SyCyRs) can induce cytokine signaling using non-physiological ligands. High-affinity GFP- and mCherry-nanobodies were fused to transmembrane and intracellular domains of the IL-6/IL-11 and IL-23 cytokine receptors gp130 and IL-12Rβ1/IL-23R, respectively. Homo- and heterodimeric GFP:mCherry fusion proteins as synthetic cytokine-like ligands were able to induce canonical signaling in vitro and in vivo...
May 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29786667/mass-transfer-in-osmotic-dehydration-of-kiwiberry-experimental-and-mathematical-modelling-studies
#6
Michał Bialik, Artur Wiktor, Piotr Latocha, Ewa Gondek
The aim of this study was to analyze the impact of osmotic solutions and temperature on the osmotic dehydration (OD) of two cultivars of kiwiberry. OD was carried out in sucrose, xylitol and maltitol solutions at 30 °C and 50 °C, respectively. The process of osmotic dehydration was described by the means of water loss (WL), solid gain (SG), weight reduction (WR), and water content changes. Moreover, dehydration was described by mathematical models often used in the literature. The highest WL, WR and SG values were observed for samples treated by xylitol and maltitol at 50 °C...
May 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29782491/community-based-benchmarking-improves-spike-rate-inference-from-two-photon-calcium-imaging-data
#7
Philipp Berens, Jeremy Freeman, Thomas Deneux, Nicolay Chenkov, Thomas McColgan, Artur Speiser, Jakob H Macke, Srinivas C Turaga, Patrick Mineault, Peter Rupprecht, Stephan Gerhard, Rainer W Friedrich, Johannes Friedrich, Liam Paninski, Marius Pachitariu, Kenneth D Harris, Ben Bolte, Timothy A Machado, Dario Ringach, Jasmine Stone, Luke E Rogerson, Nicolas J Sofroniew, Jacob Reimer, Emmanouil Froudarakis, Thomas Euler, Miroslav Román Rosón, Lucas Theis, Andreas S Tolias, Matthias Bethge
In recent years, two-photon calcium imaging has become a standard tool to probe the function of neural circuits and to study computations in neuronal populations. However, the acquired signal is only an indirect measurement of neural activity due to the comparatively slow dynamics of fluorescent calcium indicators. Different algorithms for estimating spike rates from noisy calcium measurements have been proposed in the past, but it is an open question how far performance can be improved. Here, we report the results of the spikefinder challenge, launched to catalyze the development of new spike rate inference algorithms through crowd-sourcing...
May 21, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29781620/nonadiabatic-quantum-dynamics-with-frozen-width-gaussians
#8
Loic Joubert-Doriol, Artur F Izmaylov
We review techniques for simulating fully quantum nonadiabatic dynamics using the frozen-width moving Gaussian basis functions to represent the nuclear wavefunction. A choice of these basis functions is primarily motivated by the idea of the on-the-fly dynamics that will involve electronic structure calculations done locally in the vicinity of each Gaussian center and thus avoiding "curse of dimensionality'' appearing in large systems. For quantum dynamics involving multiple electronic states there are several aspects that need to be addressed...
May 21, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29781447/singlet-and-triplet-trions-in-ws-sub-2-sub-monolayer-encapsulated-in-hexagonal-boron-nitride
#9
Diana Vaclavkova, Jan Wyzula, Karol Nogajewski, Miroslav Bartos, Artur Slobodeniuk, Clément Faugeras, Marek Potemski, Maciej Molas
Embedding a WS<sub>2</sub> monolayer in flakes of hexagonal boron nitride allowed
 us to resolve and study the photoluminescence response due to both singlet and triplet
 states of negatively charged excitons (trions) in this atomically thin semiconductor.
 The energy separation between the singlet and triplet states has been found to
 be relatively small reflecting rather weak effects of the electron-electron exchange
 interaction for the trion triplet in a WS<sub>2</sub> monolayer, which involves two electrons
 with the same spin but from different valleys...
May 21, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29780382/extracellular-purine-metabolism-is-the-switchboard-of-immunosuppressive-macrophages-and-a-novel-target-to-treat-diseases-with-macrophage-imbalances
#10
Anna Ohradanova-Repic, Christian Machacek, Celine Charvet, Franck Lager, Delphine Le Roux, René Platzer, Vladimir Leksa, Goran Mitulovic, Thomas R Burkard, Gerhard J Zlabinger, Michael B Fischer, Vincent Feuillet, Gilles Renault, Stephan Blüml, Miroslav Benko, Miloslav Suchanek, Johannes B Huppa, Takami Matsuyama, Artur Cavaco-Paulo, Georges Bismuth, Hannes Stockinger
If misregulated, macrophage (Mϕ)-T cell interactions can drive chronic inflammation thereby causing diseases, such as rheumatoid arthritis (RA). We report that in a proinflammatory environment, granulocyte-Mϕ (GM-CSF)- and Mϕ colony-stimulating factor (M-CSF)-dependent Mϕs have dichotomous effects on T cell activity. While GM-CSF-dependent Mϕs show a highly stimulatory activity typical for M1 Mϕs, M-CSF-dependent Mϕs, marked by folate receptor β (FRβ), adopt an immunosuppressive M2 phenotype. We find the latter to be caused by the purinergic pathway that directs release of extracellular ATP and its conversion to immunosuppressive adenosine by co-expressed CD39 and CD73...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29779787/a-thermodynamic-funnel-drives-bacterial-lipopolysaccharide-transfer-in-the-tlr4-pathway
#11
Roland G Huber, Nils A Berglund, Vasileios Kargas, Jan K Marzinek, Daniel A Holdbrook, Syma Khalid, Thomas J Piggot, Artur Schmidtchen, Peter J Bond
The Gram-negative bacterial outer membrane contains lipopolysaccharide, which potently stimulates the mammalian innate immune response. This involves a relay of specialized complexes culminating in transfer of lipopolysaccharide from CD14 to Toll-like receptor 4 (TLR4) and its co-receptor MD-2 on the cell surface, leading to activation of downstream inflammatory responses. In this study we develop computational models to trace the TLR4 cascade in near-atomic detail. We demonstrate through rigorous thermodynamic calculations that lipopolysaccharide molecules traversing the receptor cascade fall into a thermodynamic funnel...
April 25, 2018: Structure
https://www.readbyqxmd.com/read/29779390/-prenatally-diagnosed-case-of-pallister%C3%A2-killian-syndrome
#12
Zsolt Tidrenczel, Erika P Tardy, Edina Sarkadi, Judit Simon, Artúr Beke, János Demeter
Pallister-Killian syndrome (PKS) is a rare, sporadic genetic disorder that is caused by the mosaic presence of a supernumerary marker chromosome, isochromosome 12p. The syndrome is a polydysmorphic condition characterized by mental retardation, craniofacial dysmorphism, hypotonia, seizures, epilepsy and certain organic malformations (diaphragmatic hernia, congenital heart disease). Prenatal diagnosis is challenging due to the mosaic tissue-specific distribution of the chromosomal disorder and highly variable phenotype...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29778336/implementation-of-the-aortic-no-touch-technique-to-reduce-stroke-after-off-pump-coronary-surgery
#13
Alexander Albert, Jürgen Ennker, Yasser Hegazy, Sebastian Ullrich, Georgi Petrov, Payam Akhyari, Stefan Bauer, Eda Ürer, Ina Carolin Ennker, Artur Lichtenberg, Horst Priss, Alexander Assmann
OBJECTIVES: Despite substantial scientific effort, the relationship between stroke after coronary artery bypass grafting and the use of the aortic no-touch off-pump technique (anOPCAB) remains incompletely understood. The present study aimed to define the effect of anOPCAB on the occurrence and time point of stroke. METHODS: A total cohort of 15,042 consecutive patients underwent surgical myocardial revascularization at a single institution. After establishing anOPCAB as routine procedure, 4695 patients received surgery by 18 different surgeons using the anaortic approach...
April 11, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29777080/paroxysmal-dyskinesia-in-the-bichon-frise
#14
Mark Lowrie, Artur S P Varejão
No abstract text is available yet for this article.
May 19, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29770771/the-usefulness-of-agent-emission-imaging-high-mechanical-index-ultrasound-mode-in-the-diagnosis-of-urolithiasis-a-prospective-preliminary-study
#15
Artur Salmaslıoğlu, Mesut Bulakçı, Barış Bakır, Ravza Yılmaz, Yunus Emre Akpınar, Tzevat Tefik, Öner Şanlı, Sevda Özel, Bülent Acunas
PURPOSE: We aimed to determine the feasibility and effectiveness of agent emission imaging - high mechanical index (AEI-High MI) mode ultrasonography (US) compared with gray-scale and color Doppler US, alone or in combination, for the diagnosis of urolithiasis with reference to unenhanced computed tomography (CT). METHODS: This prospective study included 72 consecutive patients (40 males, 32 females; mean age, 45.9±14.7 years) referred by the department of urology for acute or elective symptoms of urolithiasis and confirmed to have urinary calculi on unenhanced abdominal CT, between January 2015 and June 2015...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29768577/new-palladacycle-derived-acylhydrazones-as-pre-catalysts-in-mirozoki-heck-coupling-and-oxyarylations
#16
Raquel A C Leão, Vagner D Pinho, Artur S Coelho, Arthur E Kümmerle, Paulo R R Costa
New acylhydrazone-based palladacycles are prepared and evaluated as pre-catalysts in Mirozoki-Heck and oxyarylation reactions.
May 14, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29768132/post-operative-infections-among-patients-undergoing-radical-cystectomy-at-a-tertiary-center
#17
Krystian Kaczmarek, Artur Lemiński, Aleksandra Bańcarz, Alicja Zakrzewska, Marcin Słojewski
BACKGROUND: Post-operative infection after radical cystectomy is a common complication. It is essential to identify modifiable risk factors that can predict post-operative infection to reduce the incidence of infection after radical cystectomy. We investigated the incidence of post-operative infection, associated pathogens, and risk factors for post-operative infection after radical cystectomy. PATIENTS AND METHODS: Patients who underwent radical cystectomy for bladder cancer in a single urologic department from 2014 to 2016 were included...
May 2018: Surgical Infections
https://www.readbyqxmd.com/read/29767657/structural-and-electrochemical-studies-of-tio-2-complexes-with-4-4-1e-1-e-2-5-bis-octyloxy-1-4-phenylene-bis-ethene-2-1-diyl-bis-e-n-2-5-bis-octyloxy-benzylidene-imine-derivative-bases-towards-organic-devices
#18
Anna Rozycka, Agnieszka Iwan, Krzysztof Artur Bogdanowicz, Michal Filapek, Natalia Górska, Agnieszka Hreniak, Monika Marzec
Three (4,4'-((1E,1'E)-(2,5-bis(octyloxy)-1,4-phenylene)bis(ethene-2,1-diyl))bis-(E)-N-(2,5-bis(octyloxy)benzylidene)) imine derivatives were synthesized via a condensation reaction with p-toluenesulfonic acid as a catalyst. The effects of the end groups and vinylene (-HC[double bond, length as m-dash]CH-) moieties on the structural, thermal, optical, electrochemical and photovoltaic properties of imines were investigated to check the influence of TiO2 on the imine properties. The thermal behavior of imines and their complexes with TiO2 was widely investigated using FT-IR, XRD, DSC and POM methods in order to determine the order type in the imine structure...
May 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29765533/-gstm1-gstt1-and-gstp1-polymorphisms-and-colorectal-cancer-risk-in-polish-nonsmokers
#19
Justyna Klusek, Anna Nasierowska-Guttmejer, Artur Kowalik, Iwona Wawrzycka, Piotr Lewitowicz, Magdalena Chrapek, Stanisław Głuszek
Glutathione S-transferase (GST) enzymes are responsible for cellular detoxification of many carcinogens and are important anticancer elements. This study assessed potential relationships between GSTM1 , GSTT1 , and GSTP1 polymorphisms and colorectal cancer (CRC) risk in Polish nonsmokers. We also analyzed the influence of GST gene polymorphisms on CRC clinical and histopathological features. Our study included 197 CRC patients and 104 healthy controls. GSTM1 , GSTT1 , and GSTP1 polymorphisms were evaluated using qPCR...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29765434/risk-factors-and-prognostic-role-of-an-electrical-storm-in-patients-after-myocardial-infarction-with-an-implanted-icd-for-secondary-prevention
#20
Wojciech Kwaśniewski, Artur Filipecki, Michał Orszulak, Witold Orszulak, Dagmara Urbańczyk, Robert Roczniok, Maria Trusz-Gluza, Katarzyna Mizia-Stec
Introduction: The aim of our study was to determine the risk factors for electrical storm (ES) and to assess the impact of ES on the long-term prognosis in patients after myocardial infarction (MI) with an implantable cardioverter-defibrillator (ICD) for secondary prevention of sudden cardiac death (SCD). Material and methods: We retrospectively analyzed 416 patients with coronary artery disease after MI who had an implanted ICD for secondary prevention of SCD. Fifty (12%) patients had one or more incidents of an electrical storm - the ES (+) group...
April 2018: Archives of Medical Science: AMS
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