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EUS-FNA

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https://www.readbyqxmd.com/read/29221338/the-new-transbronchial-diagnostic-approach-for-the-metastatic-lung-tumor-from-renal-cell-carcinoma-a-case-report
#1
Yu Okubo, Yuji Matsumoto, Toshiyuki Nakai, Takaaki Tsuchida, Keisuke Asakura, Noriko Motoi, Shun-Ichi Watanabe
Endobronchial ultrasound-guided needle aspiration (EBUS-TBNA) is a well-established procedure with high diagnostic yield and safety. However, the standard 22 gauge needles sometimes cause major bleeding particularly in hypervascular tumors like metastatic lung tumors from renal cell carcinoma (RCC). The 25 gauge needles are already introduced to endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), and are considered as one of the standard devices due to their comparable diagnostic outcome, lower complication risk, and the better manipulability...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218317/agreement-between-endoscopic-ultrasound-guided-fine-needle-aspiration-and-endobiliary-brush-cytology-in-suspected-pancreaticobiliary-malignancies
#2
Matthew J Sullivan, Hope Kincaid, Shashin Shah, Hiral N Shah
Background and study aims:  For suspected pancreaticobiliary malignancies, endobiliary brush cytology during endoscopic retrograde cholangiopancreatography (ERCP) remains the diagnostic test of choice despite historically poor and variable sensitivity. This has led to increased use of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) as an initial test. Recently, our institution began using a cytology brush that was designed specifically to collect a more substantial and higher-quality sample...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29201471/metastatic-renal-cell-cancer-to-thyroid-diagnosed-by-endoscopic-ultrasound-guided-fine-needle-aspiration-technique
#3
Yousef Abdel-Aziz, Tariq Hammad, Mohamad Nawras, Hayder Abdulwahid, Ali Nawras
Medical literature about the role of endoscopic ultrasound (EUS) in identifying thyroid lesions is limited. We present a case of secondary thyroid cancer from renal cell carcinoma (RCC) metastasis, diagnosed by thyroid EUS-fine needle aspiration (FNA) approach that was done for staging of esophageal adenocarcinoma, in a patient with 11-year history of complete right nephrectomy for RCC. An 81-year-old female patient underwent EUS for the evaluation of a newly discovered distal esophageal cancer. A hypoechoic, round, and well-demarcated mass that measured 26...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29199667/mediastinal-staging-for-non-small-cell-lung-cancer-revisited-it-is-being-done-under-aegis-of-icon-and-lung-cancer-consortium-asia
#4
REVIEW
D Pandey, P Ramanathan, R Pandey, K Prabhash
Mediastinal staging is a crucial factor in the decision making in patients with non-metastatic non-small cell lung cancer (NSCLC). Mediastinoscopy has historically been the gold standard for this purpose. With the advent of PET-CT, the role of an invasive staging modality like mediastinoscopy has been diminishing. Newer developments in endoscopic staging like EBUS and EUS-FNA have also provided means to get a cytological diagnosis of enlarged lymph nodes. With the meta-analyses showing encouraging results of neoadjuvant chemotherapy in operable lung cancers including the early stage disease, the sanctity of invasive mediastinal staging for the sole purpose for selecting patients for upfront surgery is debatable...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29193477/outcomes-of-endoscopic-ultrasound-guided-pancreatic-fnac-diagnosis-for-solid-and-cystic-lesions-at-manchester-royal-infirmary-based-upon-the-papanicolaou-society-of-cytopathology-pancreaticobiliary-terminology-classification-scheme
#5
P K Wright, D A Shelton, M R Holbrook, S A Thiryayi, N Narine, D Slater, D N Rana
OBJECTIVE: To compare endoscopic ultrasound (EUS)-FNAC diagnosis of pancreatic lesions with patient outcome based upon the Papanicolaou Society of Cytopathology pancreaticobiliary terminology classification scheme diagnostic categories: Panc 1 (non-diagnostic); Panc 2 (negative for malignancy/neoplasia); Panc 3 (atypical); Panc 4B (neoplastic, benign); Panc 4O (neoplastic, other); Panc 5 (suspicious of malignancy); and Panc 6 (positive/malignant). METHODS: All EUS-FNA pancreas specimens taken at Manchester Royal Infirmary in 2015 were prospectively classified according to the above scheme at the time of cytology reporting and data recorded prospectively...
November 29, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29159273/a-health-economic-evaluation-of-needle-based-confocal-laser-endomicroscopy-for-the-diagnosis-of-pancreatic-cysts
#6
Claude Le Pen, Laurent Palazzo, Bertrand Napoléon
Background and study aims:  The low sensitivity of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), especially for the diagnosis of serous cystadenomas (SCAs), can be associated with diagnostic uncertainty that can regularly lead to unnecessary surgical procedures. Needle-based confocal laser endomicroscopy (nCLE) used with EUS-FNA improves diagnostic accuracy, helping to reduce unnecessary surgery and patient follow-up. This study was conducted to evaluate the economic benefit of EUS-FNA + nCLE...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29151511/an-intrapancreatic-accessory-spleen-that-was-difficult-to-diagnose-due-to-temporal-changes-after-splenectomy
#7
Daisuke Uchida, Koichiro Tsutsumi, Hironari Kato, Hiroyuki Okada
Accessory spleen (AS) is common anomaly, and 20% of AS cases occur in the pancreatic tail(1). An intrapancreatic AS can be difficult to distinguish from pancreatic neoplasms. In most cases, an AS is described as a hypervascular and solitary tumor, but an AS sometimes takes other forms. We herein report a rare case of an intrapancreatic AS with temporal changes in its appearance after splenectomy, which mimicked aspects of pancreatic cancer. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and Tc-99m sulfur colloid scintigraphy were useful for the diagnosis...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29144794/endoscopic-ultrasound-guided-fine-needle-aspiration-eus-fna-in-the-diagnosis-of-adrenal-metastasis-in-a-high-risk-population
#8
Catherine D Zhang, Dana Erickson, Michael J Levy, Ferga C Gleeson, Diva R Salomao, Danae A Delivanis, Irina Bancos
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the diagnosis of adrenal metastasis in a high-risk population Objective: While the left adrenal gland is readily accessible via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), data regarding the utility of EUS-FNA in the diagnosis of adrenal lesions remain limited. We aimed to 1) describe the clinical context, adverse event rate, and diagnostic performance of EUS-FNA and 2) compare the safety profile and diagnostic accuracy of EUS-FNA with percutaneous adrenal biopsy...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29113789/a-case-of-lymphangioma-like-mesenteric-cysts-diagnosed-as-adenocarcinoma-of-possible-pancreatic-origin-on-eus-fna
#9
Maxime Delvincourt, Edmund M Godfrey, Adam Duckworth, Nicholas R Carroll
No abstract text is available yet for this article.
November 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29108314/utility-of-endoscopic-ultrasound-guided-fine-needle-aspiration-of-regional-lymph-nodes-that-are-proximal-to-and-far-from-the-primary-distal-esophageal-carcinoma
#10
Yusuke Shimodaira, Rebecca S Slack, Kazuto Harada, Manoop S Bhutani, Elena Elimova, Gregg A Staerkel, Nour Sneige, Jeremy Erasmus, Hironori Shiozaki, Nikolaos Charalampakis, Venkatram Planjery, Dilsa Mizrak Kaya, Fatemeh G Amlashi, Mariela A Blum, Heath D Skinner, Bruce D Minsky, Dipen M Maru, Wayne L Hofstetter, Stephen G Swisher, Jeannette E Mares, Jane E Rogers, Quan D Lin, William A Ross, Brian Weston, Jeffrey H Lee, Jaffer A Ajani
Implications of assessing the proximal and far para-tracheal or sub-carinal nodes (para-tracheal [PTN] or sub-carinal [SCN]) associated with lower primary esophageal carcinomas (ECs) are unclear. To evaluate the value of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) for PTN and SCN, we analyzed results by positron emission tomography (PET) avidity, 4 EUS node malignancy features, and EUS-FNA results in all patients with Siewert's I or II EC. Of 133 patients (PTN, n=102; SCN, n=31) with EUS-FNA, 47 (35%) patients had malignant node, leading to treatment modifications...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29081794/eus-morphology-is-reliable-in-selecting-patients-with-mucinous-pancreatic-cyst-s-most-likely-to-benefit-from-surgical-resection
#11
Siddharth Javia, Satish Munigala, Sushovan Guha, Banke Agarwal
BACKGROUND AND STUDY AIMS: Endoscopic ultrasound (EUS) surveillance of patients with mucinous pancreatic cysts relies on the assessment of morphologic features suggestive of malignant transformation. These criteria were derived from the evaluation of surgical pathology in patients with pancreatic cysts who underwent surgery. Reliability of these criteria when evaluated by EUS in identifying lesions which require surgery has still not been established. PATIENTS AND METHODS: This retrospective cohort study included seventy-eight patients who underwent surgical resection of pancreatic cysts based on EUS-FNA (fine-needle aspiration) findings suggestive of mucinous pancreatic cysts with concern for malignancy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29075963/endoscopic-evaluation-and-management-of-gastric-stromal-tumors
#12
REVIEW
Kambiz Kadkhodayan, Ehsan Rafiq, Robert H Hawes
Purpose of Review Gastrointestinal stromal tumors (GISTs) are both relatively common. Management of these lesions has been challenging with emerging interest in the endoscopic approach for both diagnostic and therapeutic interventions. Recent Findings Although these can be visualized on CT scan, endoscopic ultrasound (EUS) represents the standard method of evaluation and characterization using fine needle aspiration cytology (FNA) when indicated. While EUS-FNA can yield diagnostic cells, full characterization requires a sufficient volume of viable cells to do molecular analysis for c-KIT and determine the mitotic index...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29065734/comparison-of-22-gauge-standard-fine-needle-versus-core-biopsy-needle-for-endoscopic-ultrasound-guided-sampling-of-suspected-pancreatic-cancer-a-randomized-crossover-trial
#13
Dong Hyo Noh, Kyu Choi, Seonhye Gu, Juhee Cho, Kee-Taek Jang, Young Sik Woo, Kyu Taek Lee, Jong Kyun Lee, Kwang Hyuck Lee
BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is effective for tissue diagnosis of pancreatic mass. To improve diagnostic yield and drawbacks, 22-gauge (G) core biopsy (FNB) needle has been developed. This study aims to compare 22G FNA and FNB needles for EUS-guided sampling of suspected pancreatic cancer. METHODS: This is a randomized controlled crossover trial. A total of 60 patients with suspected unresectable pancreatic cancer referred for EUS-guided sampling were randomly assigned to two groups...
October 24, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29063486/diagnosis-and-management-of-pancreatic-cystic-neoplasms
#14
REVIEW
Malcolm Kearns, Nuzhat A Ahmad
Pancreatic cystic neoplasms (PCNs) are being diagnosed with increasing frequency. PCNs have diverse presentations, natural history, and biological behavior. Obtaining an accurate diagnosis of the type of cyst and assessing the potential for malignancy are crucial in determining the appropriate management strategy. Cross-sectional imaging with computed tomography (CT) or magnetic resonance imaging (MRI), at experienced centers, is effective in defining the type of cyst as well as identifying high-risk features...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29057146/light-scattering-spectroscopy-identifies-the-malignant-potential-of-pancreatic-cysts-during-endoscopy
#15
Lei Zhang, Douglas K Pleskow, Vladimir Turzhitsky, Eric U Yee, Tyler M Berzin, Mandeep Sawhney, Shweta Shinagare, Edward Vitkin, Yuri Zakharov, Umar Khan, Fen Wang, Jeffrey D Goldsmith, Saveli Goldberg, Ram Chuttani, Irving Itzkan, Le Qiu, Lev T Perelman
Pancreatic cancers are usually detected at an advanced stage and have poor prognosis. About one fifth of these arise from pancreatic cystic lesions. Yet not all lesions are precancerous, and imaging tools lack adequate accuracy for distinguishing precancerous from benign cysts. Therefore, decisions on surgical resection usually rely on endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). Unfortunately, cyst fluid often contains few cells, and fluid chemical analysis lacks accuracy, resulting in dire consequences, including unnecessary pancreatic surgery for benign cysts and the development of cancer...
2017: Nature Biomedical Engineering
https://www.readbyqxmd.com/read/29045075/immunocytochemistry-for-sox-11-and-tfe3-as-diagnostic-markers-for-solid-pseudopapillary-neoplasms-of-the-pancreas-in-fna-biopsies
#16
Wen-Chi Foo, Grant Harrison, Xuefeng Zhang
BACKGROUND: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare malignant tumors that can be sampled via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Although diagnosing SPNs can be straightforward in cases with a classic morphology and a typical immunoprofile, challenges can occur with morphologic variants or limited specimens. Recently, 2 immunohistochemical stains, SRY-related high-mobility group box 11 (SOX-11) and transcription factor E3 (TFE3), have been demonstrated to be highly sensitive and specific for SPNs in pancreatic resection specimens...
November 2017: Cancer
https://www.readbyqxmd.com/read/28983505/comparison-of-endoscopic-ultrasound-guided-fine-needle-aspiration-by-capillary-action-suction-and-no-suction-methods-a-randomized-blinded-study
#17
Rinkesh K Bansal, Narendra S Choudhary, Rajesh Puri, Saurabh K Patle, Suraj Bhagat, Mukesh Nasa, Amit Bhasin, Haimanti Sarin, Mridula Guleria, Randhir Sud
BACKGROUND AND STUDY AIM : Different types of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) techniques are used in clinical practice; the best method in terms of outcome has not been determined. The aim of the study was to compare the diagnostic adequacy of aspirated material, and the cytopathological and EUS morphological features between capillary action, suction, and no-suction FNA methods. PATIENTS AND METHODS:  This was a prospective, single-blinded, randomized study conducted at a tertiary care hospital...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28974904/interventional-endoscopic-ultrasound-for-a-symptomatic-pseudocyst-secondary-to-gastric-heterotopic-pancreas
#18
Hang-Bin Jin, Lei Lu, Jian-Feng Yang, Qi-Feng Lou, Jing Yang, Hong-Zhang Shen, Xiao-Wei Tang, Xiao-Feng Zhang
Heterotopic pancreas (HP) is a relatively uncommon entity that is defined as pancreatic tissue without a true anatomical or vascular connection to the pancreas. HP does not cause symptoms in most cases but can occasionally produce various manifestations, including nausea, vomiting, abdominal pain, and even heterotopic pancreatitis. Here, we report an unusual case in which heterotopic pancreatitis complicated by the formation of a pseudocyst that caused gastric outlet obstruction was diagnosed based on serum hyperamylasemia and findings from endoscopic ultrasonography (EUS)-guided fine needle aspiration (EUS-FNA) cytology...
September 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28969083/additional-k-ras-mutation-analysis-and-plectin-1-staining-improve-the-diagnostic-accuracy-of-pancreatic-solid-mass-in-eus-guided-fine-needle-aspiration
#19
Joo Kyung Park, Woo Hyun Paik, Byeong Jun Song, Ji Kon Ryu, Min A Kim, Jin Myung Park, Sang Hyub Lee, Yong-Tae Kim
BACKGROUND: One of the major genetic alterations in pancreatic ductal adenocarcinoma (PDAC) is the point mutation of K-ras gene. Plectin-1 was also recently identified as PDAC specific biomarker. The aim of this study was to investigate the improvement of diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) by using additional K-ras mutation analysis and Plectin-1 staining in patients with pancreatic mass. METHODS: A total of 85 study patients with pancreatic mass underwent EUS-FNA and the final diagnoses were as follows; PDACs: 70 patients, pancreas neuroendocrine tumor: 4, metastasis to pancreas: 5, autoimmune pancreatitis: 3, chronic pancreatitis: 1, tuberculous lymphadenitis: 1, pseudocyst: 1...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28951792/asymptomatic-pancreatic-metastasis-from-renal-cell-carcinoma-diagnosed-21-years-after-nephrectomy
#20
Megumi Zianne, Naoki Takahashi, Akihiko Tsujibata, Kazuhiro Miwa, Yoshinori Goto, Yutaka Matano
This report presents our experience with a case of pancreatic metastasis of renal cell carcinoma (RCC) at a long-term follow-up after nephrectomy. A 73-year-old man underwent nephrectomy for right RCC 21 years ago; computed tomography (CT) scanning on routine follow-up revealed a solid mass in the tail of the pancreas, and magnetic resonance imaging (MRI) showed some tumors in the head and tail of the pancreas. The patient was asymptomatic and allergic to contrast medium. Therefore we could not perform contrast CT/MRI for further examination to diagnose pancreatic tumors...
2017: Case Reports in Gastrointestinal Medicine
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