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https://www.readbyqxmd.com/read/27905047/endoscopic-ultrasound-guided-fine-needle-aspiration-biopsy-eus-fna-in-insulinomas-indications-and-clinical-relevance-in-a-single-investigator-cohort-of-47-patients
#1
Peter Herbert Kann, Roland Moll, Detlef Bartsch, Andreas Pfützner, Thomas Forst, Gianluca Tamagno, Joachim N Goebel, Verena Fourkiotis, Simona Raluca Bergmann, Maike Collienne
PURPOSE: This study was aimed to investigate the role and relevance of endoscopic ultrasound-guided fine-needle aspiration biopsy in the diagnostic work-up of insulinomas. METHODS: We have analysed the frequency, clinical indications, success rate (obtaining diagnostic tissue), diagnostic accuracy (in comparison to the pathological diagnosis after surgery), complications, and tolerability of endoscopic ultrasound-guided fine-needle aspiration biopsy and the localization and size of the lesions in 47 consecutive patients (29 females, 18 males; 46 ± 15 years) who had surgery for insulinoma following fasting test and were explored by single investigator EUS 1994-2015...
November 30, 2016: Endocrine
https://www.readbyqxmd.com/read/27895743/diagnosis-of-pancreatic-lesions-collected-by-endoscopic-ultrasound-guided-fine-needle-aspiration-using-next-generation-sequencing
#2
Eri Kameta, Kazuya Sugimori, Takashi Kaneko, Tomohiro Ishii, Haruo Miwa, Takeshi Sato, Yasuaki Ishii, Soichiro Sue, Tomohiko Sasaki, Yuki Yamashita, Wataru Shibata, Naomichi Matsumoto, Shin Maeda
Endoscopic ultrasound-guided fine-needle aspiration (EUF-FNA) has improved the diagnosis of pancreatic lesions. Next-generation sequencing (NGS) facilitates the production of millions of sequences concurrently. Therefore, in the current study, to improve the detectability of oncogenic mutations in pancreatic lesions, an NGS system was used to diagnose EUS-FNA samples. A total of 38 patients with clinically diagnosed EUS-FNA specimens were analyzed; 27 patients had pancreatic ductal adenocarcinoma (PDAC) and 11 had non-PDAC lesions...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27873469/variation-of-cytopathologists-use-of-the-indeterminate-diagnostic-categories-atypical-and-suspicious-for-malignancy-in-the-cytologic-diagnosis-of-solid-pancreatic-lesions-on-endoscopic-ultrasound-guided-fine-needle-aspirates
#3
Renu K Virk, Roberto Gamez, Swati Mehrotra, Mohammed Atieh, Güliz A Barkan, Eva M Wojcik, Stefan E Pambuccian
: Indeterminate cytologic diagnoses in endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) of solid pancreatic lesions include the diagnostic categories "atypical" (ATY) and "suspicious for malignancy" (SUSP), which are used at variable rates and are associated with variable underlying risk of malignancy. The aim of this study was to determine individual cytopathologists' rates of indeterminate diagnoses in EUS-FNA of solid pancreatic lesions and their relationship to cytopathologists' experience and volume of pancreatic EUS-FNA examined, as well as the potential impact of departmental consensus review on indeterminate diagnoses...
November 22, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27863178/fine-needle-aspiration-biopsy-of-pancreatic-neuroendocrine-tumors-correlation-between-ki-67-index-in-cytological-samples-and-clinical-behavior
#4
Cristina Díaz Del Arco, J Miguel Esteban López-Jamar, Luis Ortega Medina, J Ángel Díaz Pérez, Ma Jesús Fernández Aceñero
BACKGROUND: Mitotic count in hematoxylin-eosin stained slides and Ki-67 index allow stratification of patients for prognosis and therapeutic decision making in pancreatic neuroendocrine tumors (PNETs). However, the utility of Ki-67 determination in cytological material and its association to PNET prognosis are under discussion. METHODS: We have retrospectively reviewed all cases of EUS-FNA cytology of pancreatic lesions performed in the Hospital Clínico San Carlos (Madrid) between 2006 and 2016...
November 14, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27860444/cytological-findings-and-bcl10-expression-in-pancreatic-acinar-cell-carcinoma-a-case-report
#5
Akinobu Ohno, Yuichiro Sato, Eriko Nakamura, Hiroshi Noguchi, Takako Tokumitsu, Masahide Hiyoshi, Atsushi Nanashima, Yujiro Asada
BCL10 was recently demonstrated to be a biomarker for pancreatic acinar cell carcinoma, but whether altered BCL10 expression can be detected in cell block specimens is unclear. Here, we report a pancreatic acinar cell carcinoma with cytological findings that showed BCL10 expression in a cell block. A 72-year-old man presented with a pancreatic tumor and underwent endoscopic ultrasound-fine needle aspiration (EUS-FNA) with additional passes performed for cell block preparation. The EUS-FNA cytology showed loose cohesive clusters with focal acinar- or gland-like-structures and prominent nucleoli...
November 17, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27848241/a-mixed-adenoneuroendocrine-carcinoma-of-the-pancreas-a-case-report
#6
Kouki Imaoka, Saburo Fukuda, Hirofumi Tazawa, Yoshio Kuga, Tetsuya Mochizuki, Yuzo Hirata, Seiji Fujisaki, Mamoru Takahashi, Toshihiro Nishida, Hideto Sakimoto
A tumor consisting of an adenocarcinoma component and a neuroendocrine carcinoma component, with each component accounting for at least 30% of the tumor, is defined as a mixed adenoneuroendocrine carcinoma (MANEC). We report a case of MANEC of the pancreas. A 63-year-old man presented with hyperglycemia and was referred to our hospital for further examination. Abdominal contrast-enhanced computed tomography (CT) revealed a mass of 2 cm in size in the pancreas head with portal vein narrowing. Fluorin-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) CT revealed increased accumulation in the mass of the pancreas head...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27826620/surgical-management-for-non-functional-pancreatic-neuroendocrine-neoplasms-with-synchronous-liver-metastasis-a-consensus-from-the-chinese-study-group-for-neuroendocrine-tumors-csnet
#7
Kaizhou Jin, Jin Xu, Jie Chen, Minhu Chen, Rufu Chen, Ye Chen, Zhiyu Chen, Bin Cheng, Yihebali Chi, Shi-Ting Feng, Deliang Fu, Baohua Hou, Dan Huang, Heguang Huang, Qiang Huang, Jie Li, Ying Li, Houjie Liang, Rong Lin, An'an Liu, Jixi Liu, Xubao Liu, Ming Lu, Jie Luo, Gang Mai, Quanxing Ni, Meng Qiu, Chenghao Shao, Baiyong Shen, Weiqi Sheng, Jian Sun, Chunlu Tan, Huangying Tan, Qiyun Tang, Yingmei Tang, Xiaodong Tian, Danian Tong, Xiaohong Wang, Jian Wang, Jie Wang, Wei Wang, Wei Wang, Yu Wang, Zheng Wu, Ling Xue, Qiang Yan, Ning Yang, Yinmo Yang, Zhiying Yang, Xiaoyi Yin, Chunhui Yuan, Shan Zeng, Renchao Zhang, Xianjun Yu
Pancreatic neuroendocrine neoplasms (p-NENs) are slowly growing tumors with frequent liver metastasis. There is a variety of approaches to treat non-functional p-NENs with synchronous liver metastasis (LM) which complicates the determination of optimal treatment. Based on updated literature review, we discussed the treatment strategy determinants for p-NEN with LM. According to the resectability of primary tumor, the WHO 2010 grade classification and the radiological type of liver metastasis, the CSNET group reached agreements on a number of issues, including the following...
November 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27824027/endoscopic-retrograde-cholangiopancreatography-versus-endoscopic-ultrasound-for-tissue-diagnosis-of-malignant-biliary-stricture-systematic-review-and-meta-analysis
#8
REVIEW
Diogo Turiani Hourneaux De Moura, Eduardo Guimarães Hourneaux Moura, Wanderlei Marques Bernardo, Eduardo Turiani Hourneaux De Moura, Felipe I Baracat, Andre Kondo, Sergio Eijii Matuguma, Everson Luis Almeida Artifon
BACKGROUND AND AIMS: There are no systematic reviews comparing the use of endoscopic retrograde cholangiopancreatography (ERCP)-based brush cytology and forceps biopsy and endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) for the diagnosis of malignant biliary stricture; so in this revision, we will compare ERCP against EUS-FNA for tissue diagnosis of malignant biliary stricture. DESIGN: A systematic review was conducted of comparative studies (prospective or retrospective) analyzing EUS and ERCP for tissue diagnosis of malignant biliary stricture...
November 8, 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27818598/22-gauge-core-vs-22-gauge-aspiration-needle-for-endoscopic-ultrasound-guided-sampling-of-abdominal-masses
#9
William Sterlacci, Athanasios D Sioulas, Lothar Veits, Pervin Gönüllü, Guido Schachschal, Stefan Groth, Mario Anders, Christos K Kontos, Theodoros Topalidis, Andrea Hinsch, Michael Vieth, Thomas Rösch, Ulrike W Denzer
AIM: To compare the aspiration needle (AN) and core biopsy needle (PC) in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of abdominal masses. METHODS: Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge (G) AN (Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22G PC (EchoTip ProCore; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27818594/slow-pull-and-different-conventional-suction-techniques-in-endoscopic-ultrasound-guided-fine-needle-aspiration-of-pancreatic-solid-lesions-using-22-gauge-needles
#10
Jia-Ying Chen, Qing-Yu Ding, Yang Lv, Wen Guo, Fa-Chao Zhi, Si-De Liu, Tian-Ming Cheng
AIM: To evaluate the cytological diagnostic capacity and sample quality of the slow-pull technique and compare them with different suction techniques. METHODS: From July 2010 to December 2015, 102 patients with pancreatic solid lesions who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with 22-gauge needles were retrospectively evaluated. EUS-FNA diagnosis was based on a cytological examination, and final diagnosis was based on a comprehensive standard of cytological diagnosis, surgical pathology and clinical or imaging follow-up...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27818584/endoscopic-ultrasound-guided-techniques-for-diagnosing-pancreatic-mass-lesions-can-we-do-better
#11
REVIEW
Andrew C Storm, Linda S Lee
The diagnostic approach to a possible pancreatic mass lesion relies first upon various non-invasive imaging modalities, including computed tomography, ultrasound, and magnetic resonance imaging techniques. Once a suspect lesion has been identified, tissue acquisition for characterization of the lesion is often paramount in developing an individualized therapeutic approach. Given the high prevalence and mortality associated with pancreatic cancer, an ideal approach to diagnosing pancreatic mass lesions would be safe, highly sensitive, and reproducible across various practice settings...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27817254/cytohistological-and-immunohistochemical-characteristics-of-spindle-shaped-mesenchymal-neoplasms-occurring-in-the-gastrointestinal-tract
#12
Antonio Ieni, Valeria Barresi, Luca Reggiani Bonetti, Giovanni Branca, Rosario Alberto Caruso, Giovanni Tuccari
The purpose of the present review is to analyze the cytohistological and immunohistochemical characteristics of spindle-shaped mesenchymal gastrointestinal neoplams (MGNs), a group of unusual neoplastic conditions with different biological behavior. These tumors exhibit clinical pictures strictly related to the site of origin and dimensions, even if they appear generally with an intramural localization. This latter point may suggest an useful application of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), mainly followed by the cell-block procedure (CBP) in the differential diagnostic approach...
November 6, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27807563/rare-subepithelial-mass-diagnosed-as-gastric-splenosis-via-eus-fna
#13
Saleh Elwir, Beenu Thakral, Brooke Glessing, Elizabeth Courville, Shawn Mallery
No abstract text is available yet for this article.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27777439/a-prospective-randomized-controlled-study-comparing-eus-sonopsy-cy-r-and-22-gauge-biopsy-needles-for-endoscopic-ultrasound-guided-fine-needle-aspiration-of-solid-pancreatic-mass-lesions
#14
Sho Mizukawa, Hironari Kato, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada, Hirofumi Inoue, Noriyuki Tanaka
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a standard procedure for precise histological diagnosis of pancreas tumors, but it is sometimes difficult to obtain adequate specimens. EUS Sonopsy CY® is a newly designed needle with original features. This randomized study will compare the tissue collection rate of EUS Sonopsy CY® to that of a conventional needle in EUS-FNA. The major eligibility criteria are as follows: Patients with a pancreatic mass referred for EUSFNA; age 20 years, and performance status<4...
October 2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27773725/remote-malignant-intravascular-thrombi-eus-guided-fine-needle-aspiration-diagnosis-and-impact-on-cancer-staging
#15
Tarun Rustagi, Ferga C Gleeson, Suresh T Chari, Barham K Abu Dayyeh, Michael B Farnell, Prasad G Iyer, Michael L Kendrick, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Mark D Topazian, Mark J Truty, Santhi S Vege, Kenneth K Wang, Michael J Levy
BACKGROUND AND AIMS: Malignant vascular invasion usually results from gross direct infiltration from a primary tumor, and impacts cancer staging, prognosis, and therapy. However, patients may also develop a remote malignant thrombi (RMT), defined as a malignant intravascular thrombus located remote and noncontiguous to the primary tumor. Our aim was to compare the endoscopic ultrasound (EUS) and the computed tomography (CT) and magnetic resonance imaging (MRI) findings of RMT and impact on cancer staging and resectability...
October 20, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27761149/endoscopic-ultrasound-guided-fine-needle-aspiration-cytology-of-metastatic-renal-cell-carcinoma-to-the-pancreas-a-multi-center-experience
#16
Rahul Pannala, Karyn M Hallberg-Wallace, Amber L Smith, Aziza Nassar, Jun Zhang, Matthew Zarka, Jordan P Reynolds, Longwen Chen
INTRODUCTION: The increasing use of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) cytology to examine pancreatic neoplasms has led to an increase in the diagnosis of metastases to the pancreas. Renal cell carcinoma (RCC) is the most common metastasis to the pancreas. Our study examines 33 cases of metastatic RCC to the pancreas sampled by EUS-FNA from four large tertiary care hospitals. MATERIALS AND METHODS: We searched the cytopathology database for RCC metastatic to the pancreas diagnosed by EUS-FNA from January 2005 to January 2015...
2016: CytoJournal
https://www.readbyqxmd.com/read/27725540/the-disappearance-of-lymph-node-metastasis-from-neuroendocrine-carcinoma-after-endoscopic-ultrasound-guided-fine-needle-aspiration
#17
Masayuki Shibata, Hiroyuki Matsubayashi, Akiko Todaka, Hanako Kurai, Naoyuki Tsutsumi, Keiko Sasaki, Hiroyuki Ono
A 75-year-old Japanese man was referred to our hospital to undergo the examination of an enlarged peripancreatic lymph node. Computed tomography (CT) showed a lymph node 47 mm in size that was located above the pancreas head and beneath the liver. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of the enlarged lymph node was performed, and an immunohistological examination of the sample confirmed a histological diagnosis of neuroendocrine carcinoma (NEC). The patient refused treatment with chemotherapy and instead chose to undergo observation...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27713922/training-to-use-eus-fna-it-is-time-to-give-up-the-human-hands-on-approach
#18
Marc Barthet, Geoffroy Vanbiervliet, Jean-Michel Gonzalez
No abstract text is available yet for this article.
September 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27709855/using-forceps-biopsy-after-small-submucosal-dissection-in-the-diagnosis-of-gastric-subepithelial-tumors
#19
Yoon Suk Jung, Hyuk Lee, Kyungeun Kim, Jin Hee Sohn, Hong Joo Kim, Jung Ho Park
The current tissue sampling techniques for subepithelial tumors (SETs) of the gastrointestinal (GI) tract have limited diagnostic efficacy. We evaluated the diagnostic yield and safety of forceps biopsies after small endoscopic submucosal dissection (SESD biopsies) in the diagnosis of gastric SETs. A total of 42 patients with gastric SETs > 10 mm were prospectively enrolled between May 2013 and October 2014. A dual knife was used to incise the mucosa and submucosa and forceps biopsies were then introduced deep into the lesion...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27688080/reliability-of-ki-67-determination-in-fna-samples-for-grading-pancreatic-neuroendocrine-tumors
#20
Cristina Díaz Del Arco, J Ángel Díaz Pérez, Luis Ortega Medina, Javier Sastre Valera, M Jesús Fernández Aceñero
Neuroendocrine pancreatic tumors (PanNETs) are graded on the basis of their proliferative activity. Cytological samples are commonly the only samples available, but the determination of Ki-67 in cytology and its reliability as a measure of tumor mitotic activity is not well settled. We have retrospectively reviewed all the cases of FNA under EUS control of PanNETs in a 10-year period (2006-2016) in the Hospital Clínico San Carlos (Madrid). We identified 10 PanNET cases with histological correlation. Median age was 49...
September 29, 2016: Endocrine Pathology
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