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https://www.readbyqxmd.com/read/29777255/inhibition-of-sialidase-activity-and-cellular-invasion-by-the-bacterial-vaginosis-pathogen-gardnerella-vaginalis
#1
G Govinden, J L Parker, K L Naylor, A M Frey, D O C Anumba, G P Stafford
Bacterial vaginosis is a genital tract infection, thought to be caused by transformation of a lactobacillus-rich flora to a dysbiotic microbiota enriched in mixed anaerobes. The most prominent of these is Gardnerella vaginalis (GV), an anaerobic pathogen that produces sialidase enzyme to cleave terminal sialic acid residues from human glycans. Notably, high sialidase activity is associated with preterm birth and low birthweight. We explored the potential of the sialidase inhibitor Zanamavir against GV whole cell sialidase activity using methyl-umbelliferyl neuraminic acid (MU-NANA) cleavage assays, with Zanamavir causing a 30% reduction in whole cell GV sialidase activity (p < 0...
May 18, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29772525/vaginal-microbiota-dysmicrobism-and-role-of-biofilm-forming-bacteria
#2
Giuseppina Campisciano, Nunzia Zanotta, Vincenzo Petix, Lucia Corich, Francesco De Seta, Manola Comar
Bacterial vaginosis involves the presence of a polymicrobial biofilm on the vaginal epithelium, guaranteeing immune escape and spread of antibiotic resistance. To spot known biofilm-forming bacteria, we profiled the vaginal microbiome of sixty-four symptomatic women suffering from a different grade of vaginal disorders and sixty asymptomatic healthy women. Specific microbial profiles distinguished symptomatic from asymptomatic women and characterized the grade of dysmicrobism within the symptomatic group. Lactobacillus crispatus and iners predominated on the healthy vaginal mucosa, while Lactobacillus gasseri predominated in the intermediate dysmicrobism...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29739103/bacteramia-caused-by-gardnerella-vaginalis-in-a-cesarean-section-patient
#3
Yili Chen, Xinhong Han, Penghao Guo, Han Huang, Zhongwen Wu, Kang Liao
BACKGROUND: Gardnerella vaginalis is a facultative anaerobic and small gram-variable rod bacterium. G. vaginalis, which can be transmitted through sexual contact, is the common pathogen for the feminine bacterial pathogen (BV). Here we describe a case of bacteremia in a patient after cesarean section caused by G. vaginalis in China. Case presentation: A 35-year-old woman suffered bacteremia caused by G. vaginalis after cesarean section. This patient, without evidence of polymicrobial infection, was treated with cefuroxime and had a good outcome...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29709092/the-vaginal-microbiome-amplifies-sex-hormone-associated-cyclic-changes-in-cervicovaginal-inflammation-and-epithelial-barrier-disruption
#4
Frideborg Bradley, Kenzie Birse, Klara Hasselrot, Laura Noël-Romas, Andrea Introini, Hugo Wefer, Maike Seifert, Lars Engstrand, Annelie Tjernlund, Kristina Broliden, Adam D Burgener
PROBLEM: Susceptibility to HIV is associated with the menstrual cycle and vaginal microbiome, but their collective impact on vaginal inflammation remains unclear. Here, we characterized the cervicovaginal proteome, inflammation, and microbiome community structure and function during the menstrual cycle. METHOD OF STUDY: Cervicovaginal secretions were collected from regularly cycling women (n = 16) at median day 10, 16, and 24 of each menstrual cycle and analyzed by mass spectrometry, 16S rRNA gene sequencing, and a multiplex bead array immunoassay...
April 30, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29707229/fighting-biofilms-with-lantibiotics-and-other-groups-of-bacteriocins
#5
REVIEW
Harsh Mathur, Des Field, Mary C Rea, Paul D Cotter, Colin Hill, R Paul Ross
Biofilms are sessile communities of bacteria typically embedded in an extracellular polymeric matrix. Bacterial cells embedded in biofilms are inherently recalcitrant to antimicrobials, compared to cells existing in a planktonic state, and are notoriously difficult to eradicate once formed. Avenues to tackle biofilms thus far have largely focussed on attempting to disrupt the initial stages of biofilm formation, including adhesion and maturation of the biofilm. Such an approach is advantageous as the concentrations required to inhibit formation of biofilms are generally much lower than removing a fully established biofilm...
2018: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29686882/pyosalpinges-after-hysterosalpingography-in-a-patient-with-lower-genital-tract-infection-and-managed-by-laparoscopic-surgery-in-a-resource-low-tertiary-hospital-case-report-and-literature-review
#6
Thomas Obinchemti Egbe, Fidelia Mbi Kobenge, Metogo Mbengono Junette Arlette, Eugene Belley-Priso
Background: Pyosalpinges (a complication of pelvic inflammatory disease) is infection of the fallopian tubes and the morbidity associated with it has major health implications. We are reporting a case of pyosalpinges diagnosed after hysterosalpingography and managed by laparoscopic surgery at the Douala General Hospital, Cameroon. Case presentation: A 29-year-old single woman, an assistant nurse of the Douala tribe in Cameroon. She is G1P0010 and came to our attention because of secondary infertility of three years duration...
2018: Fertility Research and Practice
https://www.readbyqxmd.com/read/29683763/saccharomyces-cerevisiae-based-probiotic-as-novel-anti-microbial-agent-for-therapy-of-bacterial-vaginosis
#7
Samuele Sabbatini, Claudia Monari, Nathalie Ballet, Paolo Mosci, Amélie Cayzeele Decherfe Fanny Pélerin, Stefano Perito, Paolo Scarpelli, Anna Vecchiarelli
In this study, we demonstrate, for the first time, that Saccharomyces cerevisiae-based probiotic shows an inhibitory effect on Gardnerella vaginalis infection. This effect is likely due to several actions: direct interference with adherence to vaginal tissues, inhibition of sialidase activity, reduction of vaginal epithelial exfoliation. Gardnerella vaginalis does not induce vaginal inflammation and no inflammatory cytokines were, indeed, produced, by the mouse vagina, neither by Gardnerella vaginalis and by the probiotic...
April 23, 2018: Virulence
https://www.readbyqxmd.com/read/29671516/vaginitis-diagnosis-and-treatment
#8
Heather L Paladine, Urmi A Desai
Vaginitis is defined as any condition with symptoms of abnormal vaginal discharge, odor, irritation, itching, or burning. The most common causes of vaginitis are bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis. Bacterial vaginosis is implicated in 40% to 50% of cases when a cause is identified, with vulvovaginal candidiasis accounting for 20% to 25% and trichomoniasis for 15% to 20% of cases. Noninfectious causes, including atrophic, irritant, allergic, and inflammatory vaginitis, are less common and account for 5% to 10% of vaginitis cases...
March 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29651696/diversity-of-the-midstream-urine-microbiome-in-adults-with-chronic-kidney-disease
#9
Holly Kramer, Gina Kuffel, Krystal Thomas-White, Alan J Wolfe, Kavitha Vellanki, David J Leehey, Vinod K Bansal, Linda Brubaker, Robert Flanigan, Julia Koval, Anuradha Wadhwa, Michael J Zilliox
PURPOSE: To examine the characteristics of the midstream urine microbiome in adults with stage 3-5 non-dialysis-dependent chronic kidney disease (CKD). METHODS: Patients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2 ) and diuretic use were recruited from outpatient nephrology clinics. Midstream voided urine specimens were collected using the clean-catch method. The bacterial composition was determined by sequencing the hypervariable (V4) region of the bacterial 16S ribosomal RNA gene...
April 12, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29651616/significant-increase-in-cultivation-of-gardnerella-vaginalis-alloscardovia-omnicolens-actinotignum-schaalii-and-actinomyces-spp-in-urine-samples-with-total-laboratory-automation
#10
Sabrina Klein, Dennis Nurjadi, Susanne Horner, Klaus Heeg, Stefan Zimmermann, Irene Burckhardt
While total laboratory automation (TLA) is well established in laboratory medicine, only a few microbiological laboratories are using TLA systems. Especially in terms of speed and accuracy, working with TLA is expected to be superior to conventional microbiology. We compared in total 35,564 microbiological urine cultures with and without incubation and processing with BD Kiestra TLA for a 6-month period each retrospectively. Sixteen thousand three hundred thirty-eight urine samples were analyzed in the pre-TLA period and 19,226 with TLA...
April 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29648469/the-stimulation-of-the-vaginal-immune-system-with-short-term-administration-of-a-vaginal-gel-containing-fraction-of-propionibacterium-acnes-hyaluronic-acid-and-polycarbophil-is-efficacious-in-vaginal-infections-dependent-on-disorders-in-the-vaginal-ecosystem
#11
Gian Benedetto Melis, Bruno Piras, Maria Francesca Marotto, Manuela Neri, Valentina Corda, Valerio Vallerino, Alessandra Saba, Stefano Lello, Monica Pilloni, Pierina Zedda, Anna Maria Paoletti, Valerio Mais
The vaginal immune system (VIS) is the first defense against antigens recognized as foreign. Substances capable of locally activating the VIS could be a valid strategy to treat vulvo-vaginal infections (VVI), caused by changes in the vaginal ecosystem, such as bacterial vaginosis (BV), vulvo-vaginal candidiasis (CA), and mixed vaginitis (MV). Bacterial lysates, obtained by crushing bacterial cultures, exert immuno-modulatory activities. The parietal fraction from Propionibacterium acnes is a patent of Depofarma (MoglianoVeneto, Italy)...
April 12, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29643849/insights-into-vaginal-bacterial-communities-and-metabolic-profiles-of-chlamydia-trachomatis-infection-positioning-between-eubiosis-and-dysbiosis
#12
Carola Parolin, Claudio Foschi, Luca Laghi, Chenglin Zhu, Nicoletta Banzola, Valeria Gaspari, Antonietta D'Antuono, Barbara Giordani, Marco Severgnini, Clarissa Consolandi, Melissa Salvo, Roberto Cevenini, Beatrice Vitali, Antonella Marangoni
The vaginal microbiota plays a crucial role in maintaining the health and functioning of the female genital tract, preventing the colonization of urogenital pathogens and sexually transmitted infections. In this study, we characterized the vaginal bacterial communities and the metabolome associated to Chlamydia trachomatis infection (CT: 20 women), compared to healthy condition (H: 22 women) and bacterial vaginosis (BV: 19 women). A microarray-based tool (VaginArray), implemented with a real-time PCR for Gardnerella vaginalis , was used to determine the vaginal bacterial composition, whereas the metabolic profiles were assessed by a proton-based nuclear magnetic resonance (1 H-NMR) spectroscopy...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29619908/prevalence-of-sexually-transmitted-diseases-in-asymptomatic-renal-transplant-recipients
#13
Mehmet Sarier, Nevgun Sepin Ozen, Hicran Guler, Ibrahim Duman, Yücel Yüksel, Sabri Tekin, Asuman Havva Yavuz, Levent Yucetin, Mine Erdogan Yilmaz
OBJECTIVES: Sexually transmitted diseases, which may be asymptomatic, have the potential to cause serious health problems in renal transplant recipients. The aim of this study was to determine the prevalence of sexually transmitted diseases in sexually active asymptomatic renal transplant patients by using real-time multiplex polymerase chain reaction assays. MATERIALS AND METHODS: This prospective controlled study was conducted between November 2016 and January 2017 in our hospital...
April 4, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29544661/vaginosis-associated-bacteria-and-its-association-with-hpv-infection
#14
Pablo Romero-Morelos, Cindy Bandala, Julián Jiménez-Tenorio, Mariana Valdespino-Zavala, Miriam Rodríguez-Esquivel, Reyna Anaid Gama-Ríos, Artfy Bandera, Mónica Mendoza-Rodríguez, Keiko Taniguchi, Daniel Marrero-Rodríguez, Ricardo López-Romero, Eva Ramón-Gallegos, Mauricio Salcedo
BACKGROUND AND OBJECTIVE: Cervical cancer is an important health problem in our country. It is known that there are several risk factors for this neoplasm, and it has been suggested that cervical microbiome alterations could play a role in the development and progress of cancer. Bacterial vaginosis associated bacteria such as Atopobium vaginae and Gardnerella vaginalis has been suggested as potential risk factor for cervical lesions and cervical cancer. MATERIAL AND METHODS: DNA from 177 cervical scraping samples was studied: 104 belonged to women without cytological or colposcopic alterations and 73 samples from precursor lesions with previous human papillomavirus (HPV) infection history...
March 12, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29524791/polybacterial-stimulation-suggests-discrete-il-6-il-6r-signaling-in-human-fetal-membranes-potential-implications-on-il-6-bioactivity
#15
Nathalia Mayumi Noda-Nicolau, Jossimara Polettini, Márcia Guimarães da Silva, Morgan R Peltier, Ramkumar Menon
The polybacterial invasion of the amniotic cavity and risk of preterm birth is often due to cervicovaginal bacteria such as genital mycoplasmas (Mycoplasma hominis and Ureaplasma urealyticum) and Gardnerella vaginalis. The most studied biomarker associated with preterm birth is interleukin-6 (IL-6), a pleiotropic cytokine that performs different functions based on classical or trans-signaling mechanisms. This study evaluated the changes in IL-6 and IL-6 function associated accessory molecules by human fetal membranes to determine the functional availability of IL-6 assessment in an in vitro model of polybacterial infection...
April 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29518419/the-nasal-microbiome-in-asthma
#16
Mina Fazlollahi, Tricia D Lee, Jade Andrade, Kasopefoluwa Oguntuyo, Yoojin Chun, Galina Grishina, Alexander Grishin, Supinda Bunyavanich
BACKGROUND: Nasal microbiota may influence asthma pathobiology. OBJECTIVE: We sought to characterize the nasal microbiome of subjects with exacerbated asthma, nonexacerbated asthma, and healthy controls to identify nasal microbiota associated with asthma activity. METHODS: We performed 16S ribosomal RNA sequencing on nasal swabs obtained from 72 primarily adult subjects with exacerbated asthma (n = 20), nonexacerbated asthma (n = 31), and healthy controls (n = 21)...
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29505773/impact-of-contraceptive-initiation-on-vaginal-microbiota
#17
Sharon L Achilles, Michele N Austin, Leslie A Meyn, Felix Mhlanga, Zvavahera M Chirenje, Sharon L Hillier
BACKGROUND: Data evaluating the impact of contraceptives on the vaginal microbiome are limited and inconsistent. OBJECTIVE: We hypothesized that women initiating copper intrauterine device use would have increased bacterial vaginosis and bacterial vaginosis-associated microbes with use compared to women initiating and using hormonal contraceptive methods. STUDY DESIGN: Vaginal swabs (N = 1047 from 266 participants seeking contraception) for Nugent score determination of bacterial vaginosis and quantitative polymerase chain reaction analyses for assessment of specific microbiota were collected from asymptomatic, healthy women aged 18-35 years in Harare, Zimbabwe, who were confirmed to be free of nonstudy hormones by mass spectrometry at each visit...
March 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29505113/accuracy-of-syndromic-management-in-targeting-vaginal-and-cervical-infections-among-symptomatic-women-of-reproductive-age-attending-primary-care-clinics-in-dakar-senegal
#18
Mamadou Saidou Barry, Awa Ba Diallo, Mohamed Diadhiou, Ibrahima Mall, Omar Gassama, Mame Diarra Ndiaye Guèye, Serge Covi-Alavo, Epainete Gawa, Amy Ndao Fall, Aissatou Gaye Diallo, Jean Charles Moreau
OBJECTIVE: To assess the effectiveness of the WHO syndromic algorithm in the management of vaginal discharge among women of reproductive age in Dakar. METHODS: Cross-sectional study of consecutive female patients (aged 18-49 years) presenting with vaginal symptoms at six selected study sites in Dakar; of these, 276 patients were included in the analysis. Vaginal and cervical swab samples were collected and analysed to establish an aetiological diagnosis of any infection...
May 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29492333/bacterial-identification-of-the-vaginal-microbiota-in-ecuadorian-pregnant-teenagers-an-exploratory-analysis
#19
Ana María Salinas, Verónica Gabriela Osorio, Pablo Francisco Endara, Eduardo Ramiro Salazar, Gabriela Piedad Vasco, Sandra Guadalupe Vivero, Antonio Machado
Background: Bacterial vaginosis (BV) is a microbial imbalance (i.e., dysbiosis) that can produce serious medical effects in women at childbearing age. Little is known, however, about the incidence of BV or vaginal microbiota dysbiosis in pregnant teenagers in low and middle-income countries such as Ecuador. The scope of this exploratory analysis was to study the relationship between epidemiologic and microbial risk factors. Among the microbiology risk factors this study investigated five Lactobacillus species, two of them know in preview studies as microbiology risk factors for BV development ( Lactobacillus acidophilus and Lactobacillus iners ), and the last three known for being associated with a healthy vaginal tract ( Lactobacillus crispatus , Lactobacillus gasseri and Lactobacillus jensenii )...
2018: PeerJ
https://www.readbyqxmd.com/read/29477653/the-diagnosis-of-chronic-endometritis-in-infertile-asymptomatic-women-a-comparative-study-of-histology-microbial-cultures-hysteroscopy-and-molecular-microbiology
#20
Inmaculada Moreno, Ettore Cicinelli, Iolanda Garcia-Grau, Marta Gonzalez-Monfort, Davide Bau, Felipe Vilella, Dominique De Ziegler, Leonardo Resta, Diana Valbuena, Carlos Simon
BACKGROUND: Chronic endometritis is a persistent inflammation of the endometrial mucosa caused by bacterial pathogens such as Enterobacteriaceae, Enterococcus, Streptococcus, Staphylococcus, Mycoplasma, and Ureaplasma. Although chronic endometritis can be asymptomatic, it is found in up to 40% of infertile patients and is responsible for repeated implantation failure and recurrent miscarriage. Diagnosis of chronic endometritis is based on hysteroscopy of the uterine cavity, endometrial biopsy with plasma cells being identified histologically, while specific treatment is determined based on microbial culture...
February 23, 2018: American Journal of Obstetrics and Gynecology
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