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multichannel intraluminal impedance

Miguel Couselo, Vicente Ibáñez, Javier Lluna, Juan José Vila
Introduction Low values of esophageal impedance baseline (EIB) have been related to esophagitis. The aim of this study was to evaluate the diagnostic performance of EIB for erosive esophagitis (ErE) and histological esophagitis (HiE) in children studied for gastroesophageal reflux. Material and Methods Children who underwent esophageal multichannel intraluminal impedance-pH monitoring (MII-pH) and upper-endoscopy with esophageal biopsies were studied retrospectively. EIB values were obtained by MII-pH. ErE was assessed by endoscopy following the Hetzel-Dent classification; HiE was defined by basal zone hyperplasia, papillary lengthening, or inflammatory infiltration...
October 21, 2016: European Journal of Pediatric Surgery
Ivan Pavić, Irena Babić, Jasna Čepin Bogović, Iva Hojsak
OBJECTIVE: The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance-pH (MII-pH) monitoring in children with suspected laryngopharyngeal reflux (LPR). DESIGN, SETTING AND PARTICIPANTS: A prospective study including children in whom, due to LPR suggestive symptoms, MII-pH monitoring was performed at tertiary medical center from February 2012 to July 2015. INTERVENTIONS: All included children underwent same diagnostic protocol which included examination by single pulmonologist, ENT specialist and underwent 24-h MII-pH monitoring...
October 11, 2016: Clinical Otolaryngology
M M J Singendonk, M A Benninga, M P van Wijk
Recently, multichannel intraluminal impedance (MII) monitoring was added to the repertoire of tests to evaluate the (patho)physiology of gastroesophageal reflux (GER) in children. Its advantage above the sole monitoring of the esophageal pH lies in the ability of the detection of both acid and nonacid GER and to discern between liquid and gas GER. Currently, combined 24 h pH-MII monitoring is recommended for evaluation of gastro-esophageal reflux disease (GERD) and its relation to symptoms in infants and children, despite the lack of reference values in these age groups...
October 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Nicola de Bortoli, Leonardo Frazzoni, Edoardo V Savarino, Marzio Frazzoni, Irene Martinucci, Aleksandra Jania, Salvatore Tolone, Michele Scagliarini, Massimo Bellini, Elisa Marabotto, Manuele Furnari, Giorgia Bodini, Salvatore Russo, Lorenzo Bertani, Veronica Natali, Lorenzo Fuccio, Vincenzo Savarino, Corrado Blandizzi, Santino Marchi
OBJECTIVES: We aimed to evaluate the prevalence of irritable bowel syndrome (IBS) in patients with typical reflux symptoms as distinguished into gastroesophageal reflux disease (GERD), hypersensitive esophagus (HE), and functional heartburn (FH) by means of endoscopy and multichannel intraluminal impedance (MII)-pH monitoring. The secondary aim was to detect pathophysiological and clinical differences between different sub-groups of patients with heartburn. METHODS: Patients underwent a structured interview based on questionnaires for GERD, IBS, anxiety, and depression...
September 20, 2016: American Journal of Gastroenterology
Serhat Bor, Askin Erdogan, Berna Bayrakci, Esra Yildirim, Rukiye Vardar
Obesity increases the risk of gastroesophageal reflux disease (GERD). The majority of the reflux attacks occur postprandially. The influence of the speed of food intake on gastroesophageal reflux events is unclear in obese patients. To determine the influence of the speed of food intake on intraesophageal reflux events in obese patients with and without GERD. A total of 26 obese female patients were recruited. The patients underwent esophageal manometry to evaluate the upper limit of the lower esophageal sphincter and subsequently placement of a Multichannel intraluminal impedance-pH (MII-pH) catheter...
September 15, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
J J Tan, L Wang, Z F Huang, Y F Li, W D Tian, X Liu, F F Zeng, X P Li
OBJECTIVE: To evaluate the relationship between pepsin induced by laryngopharyngeal reflux and laryngeal carcinoma. METHODS: Patients with vocal cord leukoplakia(n=18) and laryngeal carcinoma(n=21) encountered in Nanfang Hospital between December 2012 and April 2014 were included and sixteen healthy volunteers were recruited as control. Laryngeal biopsy specimens were taken from the patients with laryngeal carcinoma, or vocal cord leukoplakia and control subjects for the immunohistochemical study of pepsin...
August 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Doulami Georgia, Triantafyllou Stamatina, Natoudi Maria, Albanopoulos Konstantinos, Filis Konstantinos, Leandros Emmanouil, Zografos Georgios, Theodorou Dimitrios
INTRODUCTION: It is not yet clear if laparoscopic sleeve gastrectomy (LSG) causes newly onset gastroesophageal reflux (GERD) or worsens already existing GERD. This is due to the absence of prospective studies using objective assessment measures of GERD such as pH monitoring. Our study aims at assessing GERD 1-year post-LSG procedure for obesity. MATERIALS AND METHODS: Twelve asymptomatic obese patients were studied prospectively by using 24-h multichannel intraluminal impedance-pHmetry (MIIpH) pre- and 12 months post-LSG...
September 3, 2016: Obesity Surgery
Mark Safe, Jemma Cho, Usha Krishnan
OBJECTIVE: The aim of the study was to evaluate and compare multichannel intraluminal impedance-pH (MII-pH) monitoring with standard investigations including pH testing for detecting gastroesophageal reflux disease (GERD) in children. METHODS: A retrospective review of all MII-pH studies performed between July 2007 and March 2013 at Sydney Children's Hospital. Results from MII-pH testing, esophagogastroduodenoscopy (EGD), barium meal and pepsin assay, symptoms, underlying comorbidities, age, and medication usage were evaluated...
November 2016: Journal of Pediatric Gastroenterology and Nutrition
Evan C Cumpston, Joel H Blumin, Jonathan M Bock
OBJECTIVES: Minimal data exist to define the use of contemporary dual pH with multichannel intraluminal impedance (MII) probes integrating both pharyngeal acid and impedance sensors to evaluate laryngopharyngeal reflux (LPR) symptoms in a laryngology clinic population. This study was performed to review a series of patients tested with dual pH-MII for suspected LPR symptoms and to analyze pH-MII data findings for this patient cohort. STUDY DESIGN: Case series with planned data collection...
August 23, 2016: Otolaryngology—Head and Neck Surgery
Chao Zhang, Jimin Wu, Zhiwei Hu, Chao Yan, Xiang Gao, Weitao Liang, Diangang Liu, Fei Li, Zhonggao Wang
BACKGROUND/AIMS: Respiratory symptoms are often associated with gastroesophageal reflux disease (GERD). Although the role of multichannel intraluminal impedance-pH (MII-pH) monitoring in GERD is clear, little is known regarding the characteristics of patients with respiratory symptoms based on MII-pH monitoring and anti-reflux therapy. We evaluated a cohort of GERD patients to identify the MII-pH parameters of GERD-related respiratory symptoms and to assess the anti-reflux therapy outcomes...
2016: PloS One
Chen Du, Jehad Al-Ramahi, Qingsong Liu, Yan Yan, Jack Jiang
OBJECTIVE/HYPOTHESIS: The objective of this study was to determine the validity of our laryngopharyngeal reflux (LPR) diagnostic system from our previous study (Witt et al.) against the results of a standard pH probe monitoring. We hypothesized that subjects with abnormal pH probe results demonstrate color and texture abnormalities that would be classified as LPR according to artificial neural network (ANN) analysis. STUDY DESIGN: Retrospective analysis. METHODS: Eighty-two subjects, including 18 pH-positive, 11 pH-negative, and 53 control subjects were tested for LPR through multichannel intraluminal impedance 24-hour pH (MII-24pH) monitoring...
August 6, 2016: Laryngoscope
Feroze Sidhwa, Alessandra Moore, Elaine Alligood, Piero Marco Fisichella
OBJECTIVE: To review the clinical presentation, diagnosis, and treatment options available for management of extraesophageal manifestations of gastroesophageal reflux disease (GERD) and to compare the most recent technological advances to the existing guidelines. SUMMARY BACKGROUND DATA: Extraesophageal manifestations of GERD include cough, laryngopharyngeal reflux (LPR), and asthma. Recent advances in diagnostic modalities may have outpaced the existing diagnostic and therapeutic clinical guidelines...
August 5, 2016: Annals of Surgery
Fei Dy, Janine Amirault, Paul D Mitchell, Rachel Rosen
OBJECTIVES: To determine the sensitivity of salivary pepsin compared with multichannel intraluminal impedance with pH testing (pH-MII), endoscopy, and gastroesophageal reflux disease (GERD) questionnaires. STUDY DESIGN: We prospectively recruited 50 children from Boston Children's Hospital who were undergoing pH-MII to evaluate for GERD. The patients completed 24-hour pH-MII testing, completed symptom and quality of life questionnaires, and provided a saliva specimen that was analyzed using the PepTest lateral flow test...
October 2016: Journal of Pediatrics
Seyed Mohsen Dehghani, Seyed Alireza Taghavi, Hazhir Javaherizadeh, Maryam Nasri
BACKGROUND: - Gastroesophageal reflux disease is the most common esophageal disorder in pediatrics. OBJECTIVE: - The aim of this study was to compare reflux parameters of typical and atypical symptoms of gastroesophageal reflux disease using 24-hour esophageal pH monitoring and multichannel intraluminal impedance in pediatric population. METHODS: - In this prospective study, 43 patients aged less than 18 year with suspected gastroesophageal reflux disease were enrolled...
July 2016: Arquivos de Gastroenterologia
Gerson Domingues
No abstract text is available yet for this article.
July 2016: Arquivos de Gastroenterologia
Chenxi Xie, Jinhui Wang, Yuwen Li, Niandi Tan, Yi Cui, Minhu Chen, Yinglian Xiao
Background/Aims: Anti-reflux barrier dysfunction is one of the primary mechanisms in gastroesophageal reflux disease (GERD) pathogenesis. The esophagogastric junction contractile integral (EGJ-CI) is a new metric adopted to evaluate the EGJ contractility, which implied the anti-reflux barrier function. The aim of the current study was to validate this new metric in GERD patients and its correlation with the esophageal acid exposure, as well as the efficacy of proton pump inhibitor treatment...
July 16, 2016: Journal of Neurogastroenterology and Motility
Femke A Mauritz, J M Conchillo, L W E van Heurn, P D Siersema, C E J Sloots, R H J Houwen, D C van der Zee, M Y A van Herwaarden-Lindeboom
INTRODUCTION: Laparoscopic antireflux surgery (LARS) in children primarily aims to decrease reflux events and reduce reflux symptoms in children with therapy-resistant gastroesophageal reflux disease (GERD). The aim was to objectively assess the effect and efficacy of LARS in pediatric GERD patients and to identify parameters associated with failure of LARS. METHODS: Twenty-five children with GERD [12 males, median age 6 (2-18) years] were included prospectively...
July 1, 2016: Surgical Endoscopy
Giovanni Di Nardo, Cesare Cremon, Luca Bertelli, Salvatore Oliva, Roberto De Giorgio, Nico Pagano
OBJECTIVES: To determine the incidence of inlet patch (IP) and to assess the clinical and pathological features, role of the diagnostic workup in treatment decision making, efficacy of medical and endoscopic therapy, and natural history in a pediatric population. STUDY DESIGN: Consecutive patients aged <18 years (n = 1000) undergoing esophagogastroduodenoscopy were enrolled prospectively. Biopsy specimens were obtained from IPs and the proximal and distal esophagus, stomach, and duodenum...
September 2016: Journal of Pediatrics
Li-Ping Chen, Zai-Wei Huang, Bing Xiao
OBJECTIVE: To explore the risk factors and clinical characteristics of non-erosive reflux disease (NERD) based on a prospective single disease database of functional gastrointestinal disease. METHODS: Using a customized case report form, we collected the personal and clinical data of all study participants in an online database for further analysis. High-resolution manometry and multichannel intraluminal impedance-pH monitoring were performed in some cases. RESULTS: A total of 504 NERD cases and 152 control cases were included in our database...
May 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Thomas L Carroll, Kael Nahikian, Ammar Asban, Daniel Wiener
OBJECTIVES: Prior studies demonstrate inconsistent diagnostic strategies for laryngopharyngeal reflux disease (LPR) patients who are offered laparoscopic Nissen fundoplication (Nissen). Superior symptom resolution outcomes are demonstrated in patients with accompanying typical gastroesophageal reflux (GERD) symptoms. This study aims to evaluate the efficacy of selecting patients with LPR complaints for Nissen using full column, dual pH impedance catheters (multichannel intraluminal impedance catheters [MII])...
September 2016: Annals of Otology, Rhinology, and Laryngology
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