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https://www.readbyqxmd.com/read/28413396/mammary-analogue-secretory-carcinoma-presenting-as-a-cervical-lymph-node-metastasis-of-unknown-primary-site-a-case-report
#1
Kensuke Suzuki, Masao Yagi, Akira Kanda, Yoshiki Kobayashi, Masaya Konishi, Chika Miyasaka, Takashi Tashiro, Hiroshi Iwai
BACKGROUND: Mammary analogue secretory carcinoma (MASC) is a pathological entity arising in the salivary glands first described by Skalova et al. [Am J Surg Pathol 2010;34: 599-608]. Here, we report the first case of MASC presenting as a cervical lymph node metastasis of unknown primary site together with a brief review of the literature. CASE REPORT: We present a 74-year-old male with a painless lump in his left neck. Based on the fine-needle aspiration cytological findings, a possible malignant tumor was suspected...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28251831/cytologic-findings-of-mammary-analogue-secretory-carcinoma-arising-in-the-thyroid
#2
Paula A Rodríguez-Urrego, Snjezana Dogan, Oscar Lin
Mammary analogue secretory carcinoma (MASC) of the salivary gland, first described by Skálová et al in 2010, is a tumor that morphologically and genetically resembles breast secretory carcinoma harboring ETV6-NTRK3 fusion gene. To date, only seven cases of primary thyroid MASC have been described. The overall findings are similar to those seen in the salivary gland counterpart including the ETV6-NTRK3 fusion gene. This is the second report describing the cytologic features of MASC at this primary location, which also showed a classical type papillary carcinoma component...
June 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28224460/how-phenotype-guides-management-of-the-most-common-malignant-salivary-neoplasms-of-the-larynx
#3
REVIEW
Fernando López, Michelle D Williams, Alena Skálová, Henrik Hellquist, Carlos Suárez, Iain J Nixon, Juan P Rodrigo, Antonio Cardesa, Primož Strojan, Miquel Quer, Jennifer L Hunt, Alessandra Rinaldo, Alfio Ferlito
Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. The index of suspicion for a non-squamous cell carcinoma entity should be high when a submucosal mass is present. An accurate diagnosis is mandatory due to the impact each biologic entity has on treatment and outcome...
February 21, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28060365/newly-described-salivary-gland-tumors
#4
Alena Skalova, Michal Michal, Roderick Hw Simpson
This review concentrates on three salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma (MASC), sclerosing polycystic adenoma (SPA) and cribriform adenocarcinoma of tongue and other minor salivary glands (CAMSGs). MASC is a distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25) resulting in an ETV6-NTRK3 fusion. SPA is a rare lesion often mistaken histologically for low-grade salivary carcinoma...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27837476/differing-lymphatic-vessels-density-in-salivary-adenoid-cystic-carcinoma-and-pleomorphic-adenoma
#5
Richard Salzman, I Stárek, L Kučerová, A Skálová
Benign and malignant tumours are known to express various factors inducing lymphangiogenesis. Despite their different biological behaviour, salivary pleomorphic adenomas (PA) and adenoid cystic carcinomas (SACC) show similar lymphatic network. Authors compare density of lymphatic network in these tumours. The retrospective study included 20 SACC and 20 PA from salivary tumours. Lymphatic vessel density (LVD) was identified using D2-40 antibody and counted. In SACC, intratumoral, respectively peritumoral, lymphatic vessels were identified in 100 %, respectively 93...
November 11, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27605055/salivary-gland-hybrid-tumour-revisited-could-they-represent-high-grade-transformation-in-a-low-grade-neoplasm
#6
Henrik Hellquist, Alena Skalova, Bahram Azadeh
Salivary gland hybrid tumour, first described in 1996, is a very rare neoplasm for which exact morphological criteria have not been universally agreed upon. In contrast, the concept of high-grade transformation (HGT) in salivary neoplasms has been widely accepted during the last decade, and the number of reported cases is rapidly increasing. A review of the literature revealed 38 cases of hybrid tumour reported in 22 publications. During approximately the same time period, well over 100 cases of HGT in salivary neoplasms have been reported...
December 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27526014/-new-developments-in-molecular-diagnostics-of-carcinomas-of-the-salivary-glands-translocation-carcinomas
#7
Alena Skálová, Petr Šteiner, Tomáš Vaneček
In recent years the discovery of translocations and the fusion oncogenes that they result in has changed the way diagnoses are made in salivary gland pathology. These genetic aberrations are recurrent; and at the very least serve as powerful diagnostic tools in salivary gland tumors diagnosis and classification. They also show promise as prognostic markers and hopefully as targets of therapy. In this review the 4 carcinomas currently known to harbor translocations will be discussed, namely mucoepidermoid carcinoma, adenoid cystic carcinoma, mammary analogue secretory carcinoma, and hyalinizing clear cell carcinoma...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27179279/giant-cribriform-adenocarcinoma-of-the-tongue-showing-prkd3-rearrangement
#8
H Majewska, A Skálová, I Weinreb, D Stodulski, M Hyrcza, C Stankiewicz, W Biernat
Cribriform adenocarcinoma of the tongue and minor salivary glands (CAMSG) was first described 16 years ago. It typically presents as a mass at the base of the tongue with early spread to lymph nodes, but without potential for distant metastases. In the 2005 World Health Organization Classification of Tumors the entity was classified as a possible variant of polymorphous low-grade adenocarcinoma (PLGA). Since then, more than 40 cases have been described in the English literature. Recently, PRKD1-3 translocation was found in more than 80% of CAMSGs...
March 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27179273/renal-clear-cell-carcinoma-metastasis-to-salivary-glands-a-series-of-9-cases-clinico-pathological-study
#9
H Majewska, A Skálová, K Radecka, D Stodulski, M Hyrcza, C Stankiewicz, W Biernat
Metastatic tumors involving salivary glands arising from the non-head and neck area are very rare. Renal cell carcinoma (RCC) is known for its high propensity for metastasis to unusual localizations. RCC metastasis to the maxillofacial area is an uncommon event (16%), but metastasis to salivary glands is extremely rare. We report a series of 9 such cases retrieved from two institutions. The group included 6 females and 3 males. The age at diagnosis ranged from 60 to 97 years (mean 72.6 years). The tumors involved the parotid gland in 7 cases, and the submandibular and small salivary gland of the oral cavity in 1 case each...
March 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27101824/histological-reclassification-of-parotid-gland-carcinomas-importance-for-clinicians
#10
Dominik Stodulski, Hanna Majewska, Alena Skálová, Bogusław Mikaszewski, Wojciech Biernat, Czesław Stankiewicz
Reassessment of histological specimens of salivary gland carcinomas is associated with a change of primary diagnosis in a significant number of patients. The authors evaluated the relation between reclassification/verification of histological diagnosis and the clinical course of parotid gland carcinomas. Histological and immunohistochemical examinations of 111 specimens of parotid gland carcinomas operated on during the years 1992-2010 were revised and in some cases supplemented with cytogenetic tests (FISH), to verify the diagnosis and potentially reclassify the tumours...
November 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27017314/cervical-lymph-node-metastasis-in-adenoid-cystic-carcinoma-of-oral-cavity-and-oropharynx-a-collective-international-review
#11
REVIEW
Carlos Suárez, Leon Barnes, Carl E Silver, Juan P Rodrigo, Jatin P Shah, Asterios Triantafyllou, Alessandra Rinaldo, Antonio Cardesa, Karen T Pitman, Luiz P Kowalski, K Thomas Robbins, Henrik Hellquist, Jesus E Medina, Remco de Bree, Robert P Takes, Andrés Coca-Pelaz, Patrick J Bradley, Douglas R Gnepp, Afshin Teymoortash, Primož Strojan, William M Mendenhall, Jean Anderson Eloy, Justin A Bishop, Kenneth O Devaney, Lester D R Thompson, Marc Hamoir, Pieter J Slootweg, Vincent Vander Poorten, Michelle D Williams, Bruce M Wenig, Alena Skálová, Alfio Ferlito
The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3% and 16%. Metastasis to the cervical lymph nodes of intraoral and oropharyngeal AdCC varies from 2% to 43%, with the lower rates pertaining to palatal AdCC and the higher rates to base of the tongue...
October 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/26783481/mammary-analogue-secretory-carcinoma-of-the-parotid-gland-a-third-world-country-perspective-a-case-series
#12
Huzaifah Salat, Ramiz Mumtaz, Mubasher Ikram, Nasir Ud Din
Mammary analogue secretory carcinoma (MASC) is a recently described pathological entity in major salivary glands, which was first described by Skálová et al. in 2010. Since then only a limited number of case reports/series have been published describing this tumor with the majority of them discussing the genetic and cytoarchitectural aspect of this tumor. Keeping this in view with the lack of clinical correlation with regard to this tumor, we present our approach to management of two such cases which, according to the best of our knowledge, are the first 2 cases presenting in the South Asian continent...
2015: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/26685679/salivary-acinic-cell-carcinoma-reappraisal-and-update
#13
REVIEW
V Vander Poorten, A Triantafyllou, L D R Thompson, J Bishop, E Hauben, J Hunt, A Skalova, G Stenman, R P Takes, D R Gnepp, H Hellquist, B Wenig, D Bell, A Rinaldo, A Ferlito
Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted...
November 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/26496413/mammary-analog-secretory-carcinoma-of-the-parotid-gland-a-case-report-and-literature-review
#14
Ricardo Balanzá, Rodrigo Arrangoiz, Fernando Cordera, Manuel Muñoz, Enrique Luque-de-León, Eduardo Moreno, Carlos Toledo, Edgar González
BACKGROUND: Mammary analog secretory carcinoma (MASC) was first described in 2010 by Skálová et al. This entity shares morphologic and immunohistochemical features with the secretory carcinoma (SC) of the breast. MASC usually presents as an asymptomatic mass in the parotid gland and predominantly affects men. This tumor is considered a low-grade carcinoma but has the potential for high-grade transformation. We report one MASC case and a review of world literature. CASE REPORT: A 66-year-old male patient presented because he noticed a mass of approximately 3×3cm on the right pre-auricular region...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26492182/mammary-analogue-secretory-carcinoma-of-salivary-glands-molecular-analysis-of-25-etv6-gene-rearranged-tumors-with-lack-of-detection-of-classical-etv6-ntrk3-fusion-transcript-by-standard-rt-pcr-report-of-4-cases-harboring-etv6-x-gene-fusion
#15
Alena Skálová, Tomas Vanecek, Roderick H W Simpson, Jan Laco, Hanna Majewska, Martina Baneckova, Petr Steiner, Michal Michal
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MASC), and has not been documented in any other salivary tumor type. The present study comprised a clinical and molecular analysis of 25 cases morphologically and immunohistochemically typical of MASC. They all also displayed the ETV6 rearrangement as visualized by fluorescent in situ hybridization but lacked the classical ETV6-NTRK3 fusion transcript by standard reverse-transcriptase-polymerase chain reaction...
January 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26426580/lack-of-prkd2-and-prkd3-kinase-domain-somatic-mutations-in-prkd1-wild-type-classic-polymorphous-low-grade-adenocarcinomas-of-the-salivary-gland
#16
Salvatore Piscuoglio, Nicola Fusco, Charlotte K Y Ng, Luciano G Martelotto, Arnaud da Cruz Paula, Nora Katabi, Brian P Rubin, Alena Skálová, Ilan Weinreb, Britta Weigelt, Jorge S Reis-Filho
AIMS: Polymorphous low-grade adenocarcinoma (PLGA) is the second most common intra-oral salivary gland malignancy. The vast majority of PLGAs harbour a PRKD1 E710D hot-spot somatic mutation or somatic rearrangements of PRKD1, PRKD2 or PRKD3. Given the kinase domain homology among PRKD1, PRKD2 and PRKD3, we sought to define whether PLGAs lacking PRKD1 somatic mutations or PRKD gene family rearrangements would be driven by somatic mutations affecting the kinase domains of PRKD2 or PRKD3...
June 2016: Histopathology
https://www.readbyqxmd.com/read/26296919/expression-of-vegf-c-d-and-lymphangiogenesis-in-salivary-adenoid-cystic-carcinoma
#17
Ivo Stárek, Richard Salzman, Ladislava Kučerová, Alena Skálová, Lukáš Hauer
AIMS: Some human neoplasms stimulate lymphangiogenesis through the over-production of vascular endothelial growth factors C/D (VEGF-C/D). Previously little attention has been paid to the mechanisms of lymphogenous spread of salivary adenoid cystic carcinoma (SACC). The current study investigates the presence of lymphatic network and the role of VEGF-C and VEGF-D in its formation. METHODS: The retrospective study was performed in 20 (12 females and 8 males) patients diagnosed with SACC...
October 2015: Pathology, Research and Practice
https://www.readbyqxmd.com/read/25581728/clear-cell-myoepithelial-carcinoma-of-salivary-glands-showing-ewsr1-rearrangement-molecular-analysis-of-94-salivary-gland-carcinomas-with-prominent-clear-cell-component
#18
Alena Skálová, Ilan Weinreb, Martin Hyrcza, Roderick H W Simpson, Jan Laco, Abbas Agaimy, Marina Vazmitel, Hanna Majewska, Tomas Vanecek, Peter Talarčik, Spomenka Manajlovic, Simona N Losito, Petr Šteiner, Adela Klimkova, Michal Michal
This study examines the presence of the EWSR1 rearrangement in a variety of clear cell salivary gland carcinomas with myoepithelial differentiation. A total of 94 salivary gland carcinomas with a prominent clear cell component included 51 cases of clear cell myoepithelial carcinomas de novo (CCMC), 21 cases of CCMCs ex pleomorphic adenoma (CCMCexPA), 11 cases of epithelial-myoepithelial carcinoma (EMC), 6 cases of EMC with solid clear cell overgrowth, and 5 cases of hyalinizing clear cell carcinoma of minor salivary glands...
March 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/25503077/mammary-analogue-secretory-carcinoma-of-salivary-glands-a-new-entity-associated-with-etv6-gene-rearrangement
#19
Hanna Majewska, Alena Skálová, Dominik Stodulski, Adéla Klimková, Petr Steiner, Czesław Stankiewicz, Wojciech Biernat
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumour that harbours the recurrent ETV6-NTRK3 translocation. This is the first series of MASC cases identified in the historic cohort of carcinomas of salivary glands with clinical/pathological correlation and follow-up data. We reviewed 183 primary carcinomas of major and minor salivary glands resected at the Medical University of Gdańsk, Poland, between 1992 and 2012. Based on morphology and immunohistochemistry, cases suspicious for MASC were selected, and the diagnosis was confirmed by fluorescence in situ hybridization (FISH) for ETV6 rearrangement and by RT-PCR for the ETV6-NTRK3 fusion transcript...
March 2015: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/25240283/hotspot-activating-prkd1-somatic-mutations-in-polymorphous-low-grade-adenocarcinomas-of-the-salivary-glands
#20
Ilan Weinreb, Salvatore Piscuoglio, Luciano G Martelotto, Daryl Waggott, Charlotte K Y Ng, Bayardo Perez-Ordonez, Nicholas J Harding, Javier Alfaro, Kenneth C Chu, Agnes Viale, Nicola Fusco, Arnaud da Cruz Paula, Caterina Marchio, Rita A Sakr, Raymond Lim, Lester D R Thompson, Simion I Chiosea, Raja R Seethala, Alena Skalova, Edward B Stelow, Isabel Fonseca, Adel Assaad, Christine How, Jianxin Wang, Richard de Borja, Michelle Chan-Seng-Yue, Christopher J Howlett, Anthony C Nichols, Y Hannah Wen, Nora Katabi, Nicholas Buchner, Laura Mullen, Thomas Kislinger, Bradly G Wouters, Fei-Fei Liu, Larry Norton, John D McPherson, Brian P Rubin, Blaise A Clarke, Britta Weigelt, Paul C Boutros, Jorge S Reis-Filho
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
November 2014: Nature Genetics
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