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Pei-Pei Zhang, Lei Zhou, Jia-Shi Cao, Yi-Ping Li, Zhi Zeng, Ni Sun, Li Shen, Hao-Yue Zhu, Yang Ruan, Wen-Ting Zha, Xin-Yu Wang, Ke-Qiang Zhang, Ran Zhang
The present study was conducted to investigate the prevalence of HPV infection in epithelial ovarian cancer (EOC) in Hunan province. DNA samples were collected from paraffin embedded ovarian tissue from 322 patients with EOC, 99 with ovarian benign tumors and 199 normal persons. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The relationship between the infection of human papillomavirus (HPV) and the epithelial ovarian carcinoma (EOC) was investigated combined with clinical data...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Tong Li, Yan Li, Guo-Xian Yang, Peng Shi, Xiao-Ying Sun, Yu Yang, Ying-Ying Li, Yang Liu
OBJECTIVES: The objective of this study was to assess the diagnostic value of combination of human papillomavirus (HPV) testing and cytology as compared to isolated cytology in screening cervical cancer. MATERIALS AND METHODS: We searched public databases including PubMed and Embase before September 30, 2014. Sensitivity, specificity, positive likelihood ratio (LR), negative LR, and diagnostic odds ratio (DOR) of the two methods from included studies were meta-analyzed...
January 2016: Journal of Cancer Research and Therapeutics
Zheng Li, Feng Liu, Si Cheng, Lei Shi, Zhiling Yan, Jie Yang, Li Shi, Yufeng Yao, Yanbing Ma
Human papillomavirus (HPV) infection plays a key role in the development of cervical cancer. The aim of the current study was to investigate the HPV type distribution in Chinese women from Yunnan Province, southwest China. A total of 28,457 individuals ranging in age from 17-84 years were recruited from 13 clinical hospitals located in 10 different regions of Yunnan Province. Cervicovaginal swabs were collected from each participant, and HPV screening was performed using Luminex xMAP technology. Our results showed that the HPV prevalence was 12...
2016: Scientific Reports
Ying Shi, Song-Ling Peng, Li-Fang Yang, Xue Chen, Yong-Guang Tao, Ya Cao
Viral infections contribute to approximately 12% of cancers worldwide, with the vast majority occurring in developing countries and areas. Two DNA viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), are associated with 38% of all virus-associated cancers. The probability of one patient infected with these two distinct types of viruses is increasing. Here, we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis...
2016: Chinese Journal of Cancer
Wei Wei, Qi Shi, Nai-Song Zhang, Kang Xiao, Li-Na Chen, Xiao-Dong Yang, Jia-Fu Ji, Xiao-Ping Dong
Prion protein (PrP) is a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein that functions as a unique pathogenic agent in transmissible spongiform encephalopathy (TSE). In the past decade, overexpression of PrP was observed in a number of human malignant tumors, such as gastric, breast and pancreatic cancer. However, the role of PrP expression in squamous cell carcinoma is rarely documented. To screen PrP expression in head and neck squamous cell carcinoma (HNSCCs), the paraffin-embedded specimens of 92 pathologically diagnosed HNSCCs were assessed by PrP-specific immunohistochemistry (IHC)...
February 2016: Oncology Reports
Meiqun Jia, Jing Han, Dong Hang, Jie Jiang, Minjie Wang, Baojun Wei, Juncheng Dai, Kai Zhang, Lanwei Guo, Jun Qi, Hongxia Ma, Jufang Shi, Jiansong Ren, Zhibin Hu, Min Dai, Ni Li
Given that only a small proportion of women infected by high-risk human papillomavirus (hrHPV) develop cervical cancer, it's important to identify biomarkers for distinguishing women with hrHPV positivity who might develop cervical cancer from the transient infections. In this study, we hypothesized that human leukocyte antigens (HLA) susceptibility alleles might contribute to cervical cancer risk among females infected by hrHPV, and interact with hrHPV types. A case-control study with 593 cervical cancer cases and 407 controls (all hrHPV positive) was conducted to evaluate the effect of eight HLA-related single-nucleotide polymorphisms (SNPs) and their interactions with hrHPV types on the risk of cervical cancer...
June 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
L Li, Y L Tian, X M Lv, H F Yu, Y Y Xie, J D Wang, W Shi
We selected six tagged single nucleotide polymorphisms (SNPs) in the interleukin 17A (IL-17A) and IL-17F genes, and evaluated the relationship between the six common SNPs and environmental factors in cervical cancer patients. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the IL-17A (rs2275913, rs3748067, and rs3819025) and IL-17F (rs763780, rs9382084, and rs1266828) SNPs. The associations between IL-17A and IL-17F gene polymorphisms and risk of cervical cancer were estimated by conditional logistic regression...
2015: Genetics and Molecular Research: GMR
Yong-Hua Shi, Bo-Wei Wang, Talaf Tuokan, Qiao-Zhi Li, Ya-Jing Zhang
A micronucleus is an additional small nucleus formed due to chromosomes or chromosomal fragments fail to be incorporated into the nucleus during cell division. In this study, we assessed the utility of micronucleus counting as a screening tool in cervical precancerous lesions in Thinprep cytological test smears under oil immersion. High risk HPV was also detected by hybrid capture-2 in Thinprep cytological test smears. Our results showed that micronucleus counting was significantly higher in high-grade squamous intraepithelial lesion (HSIL) and invasive carcinoma cases compared to low-grade squamous intraepithelial lesion (LSIL) and non-neoplastic cases...
2015: International Journal of Clinical and Experimental Pathology
Lanwei Guo, Juan Wen, Jing Han, Jie Jiang, Shuanghua Xie, Xiaoshuang Feng, Baojun Wei, Juncheng Dai, Kai Zhang, Jun Qi, Hongxia Ma, Jufang Shi, Jiansong Ren, Yue Zhang, Min Dai, Zhibin Hu, Ni Li
Zinc ribbon domain containing 1 (ZNRD1) may play integral roles in immune response against HPV infection and cervical cancer. Its antisense transcript, ZNRD1-AS1, is an important regulator of ZNRD1. By bioinformatics analyses, we identified that several single nucleotide polymorphisms (SNPs) in ZNRD1-AS1 may be expression quantitative trait loci (eQTLs) for ZNRD1. So we hypothesized that these eQTLs SNPs in ZNRD1-AS1 may influence the susceptibility of cervical cancer through influencing ZNRD1 expression. We designed a population-based case-control study containing 1486 cervical cancer patients and 1536 controls to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and rs9261204) in ZNRD1-AS1 with the risk of cervical cancer...
2015: American Journal of Cancer Research
Shi-Rong Li, Zhen-Ming Wang, Yu-Hui Wang, Xi-Bo Wang, Jian-Qiang Zhao, Hai-Bin Xue, Fu-Guo Jiang
BACKGROUND: Detection of cervical high grade lesions in patients with atypical squamous cells of undetermined significance (ASCUS) is still a challenge. Our study tested the efficacy of the paired boxed gene 1 (PAX1) methylation analysis by methylation-sensitive high-resolution melting (MS-HRM) in the detection of high grade lesions in ASCUS and compared performance with the hybrid capture 2 (HC2) human papillomavirus (HPV) test. MATERIALS AND METHODS: A total of 463 consecutive ASCUS women from primary screening were selected...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Jin-Yun Li, Tao Huang, Cheng Zhang, Dan-Jie Jiang, Qing-Xiao Hong, Hui-Hui Ji, Meng Ye, Shi-Wei Duan
Cervical carcinoma is the main cause of cancer-related mortality in women and is correlated with more than 15 risk cofactors, including infection of cervical cells with high-risk types of HPV (hrHPV). Indeed, both aberrant methylation of the RASSF1A promoter and hrHPV infection are often observed in cervical carcinomas. The purpose of our meta-analysis was to evaluate the role of RASSF1A promoter methylation and hrHPV infection in cervical cancer. Our meta-analysis involved 895 cervical cancer patients and 454 control patients from 15 studies...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Dongxiao Hu, Jiansong Zhou, Fenfen Wang, Haiyan Shi, Yang Li, Baohua Li
PURPOSE: Cadherin switch, as a key hallmark of epithelial-mesenchymal transition (EMT), is characterized by reduced E-cadherin expression and increased N-cadherin or P-cadherin expression, and has been implicated in many aggressive tumors, but the importance and regulatory mechanism of cadherin switch in cervical cancer have not been investigated. Our study aimed to explore the role of cadherin switch by regulation of HPV-16 E6/E7 in progression and metastasis of cervical cancer. METHODS: The expressions of E-cadherin and P-cadherin were examined by immunohistochemical staining in 40 cases of high-grade cervical lesions with HPV-16 infection only in which HPV-16 E6 and E7 expression had been detected using qRT-PCR method...
December 2015: Archives of Gynecology and Obstetrics
Li Ma, Xiao Cong, Meilu Bian, Mai Shi, Xiuhong Wang, Jun Liu, Haiyan Liu
OBJECTIVE: To explored high-risk HPV genotyping PCR testing whether as a feasible means for the early screening of cervical cancer and precancerous lesions. METHODS: From January 2013 to June 2014, 15,192 outpatients in China-Japan Friendship Hospital voluntary were tested by high-risk type HPV genotyping PCR. The average age of them were (33±8) years old. High-risk HPV types genotyping PCR tested by fluorescence PCR technology, in which 13 kinds of high-risk HPV subtypes were detected, including HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68...
April 2015: Zhonghua Fu Chan Ke za Zhi
Feng Xu, Meng Cao, Qinfeng Shi, Hongwei Chen, Yili Wang, Xu Li
Integration of high-risk human papillomavirus (HPV) into the host genome is a key event for cervical carcinogenesis. Different methods have been used to explore the physical states of the HPV genome to reveal the mechanisms for malignant transformation of the infected cells. Consensus has been reached that, although variable portions of the HPV genome are deleted in the integrated HPV sequences, common disruption of the viral E2 gene has been demonstrated in different studies. The head-to-tail concatemers of the full-length HPV16 genome is another typical integration pattern of HPV16, typically found in Caski cell lines, but its prevalence in cervical cancer has never been tested...
April 2015: Virus Genes
Hui Gao, Zhengfang Huang, Chenlong Shi, Houda Li
A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human papilloma virus infections. pINV was cloned by polymerase chain reaction and the human papillomavirus (HPV)16 E6/7 gene was obtained from the cancer tissue samples of patients with cervical carcinoma at the Yangzhou Maternal and China Health-Care Center of Jinagsu Province (Yangzhou, China)...
February 2015: Oncology Letters
Li-Xia Bai, Jin-Tao Wang, Ling Ding, Shi-Wen Jiang, Hui-Jie Kang, Chen-Fei Gao, Xiao Chen, Chen Chen, Qin Zhou
Fragile histidine triad (FHIT) is a suppressor gene related to cervical cancer through CpG island hypermethylation. Folate is a water-soluble B-vitamin and an important cofactor in one-carbon metabolism. It may play an essential role in cervical lesions through effects on DNA methylation. The purpose of this study was to observe effects of folate and FHIT methylation and HPV 16 on cervical cancer progression. In this study, DNA methylation of FHIT, serum folate level and HPV16 status were measured using methylation-specific polymerase chain reaction (MSP), radioimmunoassay (RIA) and polymerase chain reaction (PCR), respectively, in 310 women with a diagnosis of normal cervix (NC, n=109), cervical intraepithelial neoplasia (CIN, n=101) and squamous cell carcinoma of the cervix (SCC, n=101)...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Shao Hui Huang, John N Waldron, Michael Milosevic, Xiaowei Shen, Jolie Ringash, Jie Su, Li Tong, Bayardo Perez-Ordonez, Ilan Weinreb, Andrew J Bayley, John Kim, Andrew Hope, B C John Cho, Meredith Giuliani, Albiruni Razak, David Goldstein, Willa Shi, Fei-Fei Liu, Wei Xu, Brian O'Sullivan
BACKGROUND: The objective of this study was to investigate the prognostic value of the pretreatment circulating neutrophil count (CNC), circulating monocyte count (CMC), and circulating lymphocyte count (CLC) in human papillomavirus (HPV)-related (HPV+) and HPV-unrelated (HPV-) oropharyngeal cancer (OPC). METHODS: All p16-confirmed HPV+ and HPV- OPC cases treated with chemoradiotherapy from 2000 to 2010 were included. Overall survival (OS) and recurrence-free survival (RFS) were compared for high and low CNCs, CMCs, and CLCs (dichotomized by median values)...
February 15, 2015: Cancer
Shi Min Zhuang, Xi-Fu Wu, Jing-Jia Li, Ge-Hua Zhang
Cancer of unknown primary site (CUP) is an intriguing clinical phenomenon found in ~3-9% of all head and neck cancers. It has not yet been determined whether CUP forms a distinct biological entity with specific genetic and phenotypic characteristics, or whether it is the clinical presentation of metastasis in patients with an undetected primary tumor and no visible clinical signs. The treatment of patients with cervical lymph node metastases from CUP remains controversial, due to the lack of randomized clinical trials comparing different treatment options...
November 2014: Molecular and Clinical Oncology
Shu-Zhen Qi, Shao-Ming Wang, Ju-Fang Shi, Qian-Qiu Wang, Xiang-Sheng Chen, Li-Jun Sun, An Liu, Nanci Zhang, Ning Jiang, Priya Siva, Xiu-Lian Xu, You-Lin Qiao
BACKGROUND: Genital warts (GW) are the most common sexually transmitted infections. To date, few studies using a human papillomavirus (HPV)-specific questionnaire have focused on the impact of quality of life (QoL) among patients with GW in developing countries. The origins of GW related psychosocial burdens and variations between genders were poorly characterized as well. METHODS: A hospital-based survey was conducted in Beijing and Nanjing of China in 2008. Eligible patients aged 18-65 who had a diagnosis of GW within 3 months were recruited...
2014: BMC Public Health
Cairong Zhu, Bryan A Bassig, Yawei Zhang, Kunchong Shi, Peter Boyle, Ni Li, Tongzhang Zheng
We investigated the incidence trends for adenocarcinoma (AC) of the cervix among individuals belonging to the 20-44-year age group in the USA and compared the observed birth cohort incidence patterns with the changing patterns of exposure to potential risk factors associated with AC of the cervix, such as infection with human papillomavirus, use of diethylstilbestrol (DES), obesity, and use of oral contraceptives. Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program for 1973-2010, we conducted age-period-cohort modeling to evaluate birth cohort patterns on incidence trends of AC of the cervix over time...
May 2015: European Journal of Cancer Prevention
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