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https://www.readbyqxmd.com/read/28194183/regulation-of-stem-cell-properties-of-m%C3%A3-ller-glia-by-jak-stat-and-mapk-signaling-in-the-mammalian-retina
#1
REVIEW
Krista M Beach, Jianbo Wang, Deborah C Otteson
In humans and other mammals, the neural retina does not spontaneously regenerate, and damage to the retina that kills retinal neurons results in permanent blindness. In contrast to embryonic stem cells, induced pluripotent stem cells, and embryonic/fetal retinal stem cells, Müller glia offer an intrinsic cellular source for regenerative strategies in the retina. Müller glia are radial glial cells within the retina that maintain retinal homeostasis, buffer ion flux associated with phototransduction, and form the blood/retinal barrier within the retina proper...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28166405/recurrent-quantum-scars-in-a-mesoscopic-graphene-ring
#2
Damien Cabosart, Alexandre Felten, Nicolas Reckinger, Andra Iordanescu, Sébastien Toussaint, Sébastien Faniel, Benoit Hackens
When coherent charge carriers cross micron-scale cavities, their dynamics can be governed by a few resonant states, also called "quantum scars", determined by the cavity geometry. Quantum scars can be described using theoretical tools, but have also been directly imaged in the case of high quality semiconductor cavities, as well as in disordered graphene devices, thanks to Scanning Gate Microscopy (SGM). Here, we discuss spatially-resolved SGM images of low temperature charge transport through a mesoscopic ring fabricated from high quality monolayer graphene lying on top of hexagonal boron nitride...
February 6, 2017: Nano Letters
https://www.readbyqxmd.com/read/28135202/using-a-radial-diffusion-method-to-investigate-the-role-of-plasmin-degradation-of-fibrin-in-a-physical-model-of-an-early-phase-wound
#3
Chima P Chukwuemeka, Jann Cupp, Jonathan R Sanders
BACKGROUND: Fibrin clot formation, which acts to stabilize a wound following injury, is among the key early aspects of dermal wound healing. This preliminary matrix is eventually degraded via a process known as fibrinolysis and replaced with a collagen-rich matrix that continues to be remodeled to minimize scarring. Disruptions in these carefully coordinated events lead to certain undesirable conditions such as fibrosis and the formation of abnormal scars that are associated with excess amounts of collagen...
January 23, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28106972/endoscopic-hand-drill-for-management-of-tracheal-stenosis
#4
Sandro Batzella Sandro Batzella, Gabriele Lucantoni, Giovanni Galluccio, Mario Santini, Umberto Caterino Umberto Caterino, Alfonso Reginelli, Alfonso Fiorelli Alfonso Fiorelli
We propose the use of a new endoscopic drill for management of web-like tracheal stenosis. Our device allows creating radial holes within stenosis that facilitates the use of the scissors for cutting the  scar and the subsequent mechanical dilatation.
January 17, 2017: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/28062979/contemporary-indications-for-diagnostic-open-biopsy-in-women-assessed-for-screen-detected-breast-lesions-a-ten-year-single-institution-series-of-814-consecutive-cases
#5
Gelareh Farshid, P Grantley Gill
PURPOSE: In contemporary practice, 5% of women with non-malignant needle biopsies of screen-detected lesions still require diagnostic open biopsy (OBx). Our aims are to (i) capture a snapshot of the contemporary indications for OBx in screen-detected lesions; (ii) determine upgrade rates to malignancy (DCIS or invasive cancer); (iii) identify indications with sufficiently low upgrades to justify avoidance of OBx and (iv) propose plausible non-surgical alternatives. METHODS: Between Jan 2005 and Dec 2014, women assessed for a screen-detected lesion and recommended for OBx are included...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28041765/-the-thin-alt-perforator-flap-for-oropharyngeal-robotic-assisted-reconstruction
#6
Q Qassemyar, P Aguilar, S Temam, F Kolb, P Gorphe
Since a few years, the transoral robotic surgery reduced the morbidity of oropharyngeal tumors excision. Large posterior tumors can now be removed without any scar visible on the face. In this context and to respect the thinness required for reconstructions at the junction of the upper aerodigestive tract, the free radial forearm flap still remains the solution of choice. However, if the transoral robotic surgery respects the anatomy and the aesthetics of patients at the visible and social area that represents the face, the forearm flap provides visible scars on the other region of social interaction that represents the upper limb...
December 29, 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27894573/pre-expanded-anterolateral-thigh-perforator-flap-for-phalloplasty
#7
REVIEW
Salvatore D'Arpa, Britt Colebunders, Filip Stillaert, Stan Monstrey
The anterolateral thigh (ALT) perforator flap for phalloplasty is gaining popularity because it avoids the well-known scars of the radial forearm flap. However, scars are not eliminated, just moved to a different location, the thigh, that can for some patients be of great sexual value. Preexpansion of the ALT flap allows primary donor site closure, thus avoiding not only the unsightly appearance of a skin grafted ALT donor site, but also the skin graft donor site scar. Preoperative perforator location by means of computed tomography angiography allows safe expander placement through 2 small remote incisions...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27870779/painless-acanthamoeba-keratitis-with-normal-vision
#8
Pui Wai Rachel Kwok, Ka Wai Kam, Vishal Jhanji, Alvin L Young
PURPOSE: To report an atypical case of contact lens-related Acanthamoeba keratitis. CASE REPORT: A 15-year-old secondary school female student with a history of soft contact lens wear was referred to our hospital by a private general practitioner for management of right eye redness and discomfort for 2 weeks. Upon examination, the best-corrected visual acuity was 20/20 and 20/16 for her right and left eyes, respectively. There was diffuse radial keratoneuritis noted in the cornea of her right eye without any associated epithelial defect...
November 19, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27718416/when-pathological-and-radiological-correlation-is-achieved-excision-of-fibroadenoma-with-lobular-neoplasia-on-core-biopsy-is-not-warranted
#9
C Fives, C J O'Neill, R Murphy, M A Corrigan, M J O'Sullivan, L Feeley, M W Bennett, F O'Connell, T J Browne
BACKGROUND: The diagnosis and management of lobular neoplasia (LN) including lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) remains controversial. Current management options after a core needle biopsy (CNB) with lobular neoplasia (LN) incorporating both ALH and LCIS include excision biopsy or careful clinical and radiologic follow up. METHODS: A retrospective analysis of the surgical database at Cork University Hospital was performed to identify all core needle biopsies from January 1st 2010 to 31st December 2013 with a diagnosis of FA who subsequently underwent surgical excision biopsy...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27681693/pathologic-high-risk-lesions-diagnosis-and-management
#10
Melissa Murray
Percutaneous imaging-guided core needle biopsy (CNB) is a less invasive and less expensive alternative to surgical biopsy for the evaluation of breast lesions. After a CNB the radiologist determine if there is concordance between the pathology, imaging, and clinical findings. Patient management after CNB diagnosis of high-risk breast lesion varies. Surgical excision is warranted for lesions yielding a CNB diagnosis of ADH; however controversy exists regarding the need for surgical excision after CNB diagnosis of radial scar, papillary lesion, atypical lobular hyperplasia (ALH), or lobular carcinoma in situ (LCIS)...
December 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27679785/surgical-treatment-of-unstable-distal-radius-fractures-with-a-volar-variable-angle-locking-plate-clinical-and-radiological-outcomes
#11
Kavin Khatri, Vijay Sharma, Kamran Farooque, Vivek Tiwari
BACKGROUND: Unstable distal end radius fractures are difficult to manage and so various treatment modalities have been described. The use of variable-angle locking plates is promoted for the management of these fractures. OBJECTIVES: This study aimed to evaluate the functional and radiological outcomes in unstable distal end radius fractures treated with variable-angle locking plates. PATIENTS AND METHODS: We reviewed 23 unstable distal end radius fractures that were treated at our institution with volar variable-angle locking plates...
June 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/27585486/polymer-infiltrated-ceramic-network-structures-for-resistance-to-fatigue-fracture-and-wear
#12
Haifa El Zhawi, Marina R Kaizer, Asima Chughtai, Rafael R Moraes, Yu Zhang
OBJECTIVE: To investigate fatigue fracture resistance and wear behavior of a polymer infiltrated ceramic network (PICN) material (ENAMIC, Vita Zahnfabrik). METHODS: Anatomically shaped ENAMIC monolithic crowns were milled using a CAD/CAM system. The crowns were cemented on aged dentin-like composite abutments (Z100, 3M ESPE) with resin-based cement (Vita DUO Cement, Vita). The specimens were subjected to 2 types of fatigue and wear tests: (1) accelerated sliding-contact mouth-motion step-stress fatigue test (n=24) in water; and (2) long-term sliding-contact mouth-motion fatigue/wear test using a clinically relevant load (P=200N, n=8) in water...
November 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27585202/forearm-and-hand-function-after-radial-artery-harvest-for-coronary-artery-bypass-grafting-subjective-patients-assessment
#13
Anna Drohomirecka, Paweł Kwinecki, Witold Gwóźdź, Mariusz Mieczyński, Piotr Stępiński, Jarosław Jasiński, Krzysztof Stręk, Romulad Cichoń
BACKGROUND: As arterial myocardial revascularization is proved to provide great results, radial artery use as a graft and its consequences remain an important issue. OBJECTIVES: The aim of the study was to evaluate how patients assess their forearm and hand function after radial artery harvest for coronary artery bypass grafting (CABG). METHODS: 50 patients (mean age 52.2 ± 7.4 years) who underwent CABG at least 6 months (median follow up 11...
August 23, 2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/27549804/improved-border-sharpness-of-post-infarct-scar-by-a-novel-self-navigated-free-breathing-high-resolution-3d-whole-heart-inversion-recovery-magnetic-resonance-approach
#14
Tobias Rutz, Davide Piccini, Simone Coppo, Jerome Chaptinel, Giulia Ginami, Gabriella Vincenti, Matthias Stuber, Juerg Schwitter
The border zone of post-infarction myocardial scar as identified by late gadolinium enhancement (LGE) has been identified as a substrate for arrhythmias and consequently, high-resolution 3D scar information is potentially useful for planning of electrophysiological interventions. This study evaluates the performance of a novel high-resolution 3D self-navigated free-breathing inversion recovery magnetic resonance pulse sequence (3D-SN-LGE) vs. conventional 2D breath-hold LGE (2D-LGE) with regard to sharpness of borders (SBorder) of post-infarction scar...
December 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27542917/radial-scar-at-percutaneous-breast-biopsy-that-does-not-require-surgery
#15
Rachelle Y Leong, Manpreet K Kohli, Nebraz Zeizafoun, Amy Liang, Paul I Tartter
BACKGROUND: Surgical excision is currently recommended after pathologic radial scar is found on breast core needle biopsy because surgical upgrade to carcinoma is not uncommon. The goal of our study was to identify the true pathologic upgrade rate for a "pure" radial scar, those without associated proliferative lesion, based on indication for biopsy, biopsy type, and needle size. STUDY DESIGN: The pathology database of Continuum Health Partners was searched for the terms radial scar and radial sclerosing lesion, from January 2007 to December 2015...
November 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27540716/clinical-and-radiologic-follow-up-study-for-biopsy-diagnosis-of-radial-scar-radial-sclerosing-lesion-without-other-atypia
#16
Elizabeth Tágide Kalife, Ana P Lourenco, Grayson L Baird, Yihong Wang
To determine the incidence of malignancy for radial scars (RS)/radial sclerosing lesions (RSL) without associated atypia or malignancy identified at needle biopsy. Retrospective review of the pathology data base from January 2004 to July 2013 yielded 100 needle biopsies diagnosed as RS/RSL without associated atypia/malignancy. The RS/RSL was considered "incidental" if the target was calcifications and "targeted" if imaging revealed a mass, architectural distortion, or suspicious magnetic resonance imaging enhancement...
November 2016: Breast Journal
https://www.readbyqxmd.com/read/27538926/three-dimensional-speckle-tracking-echocardiography-and-cardiac-magnetic-resonance-for-left-ventricular-chamber-quantification-and-identification-of-myocardial-transmural-scar
#17
M F A Aly, S A Kleijn, R F Menken-Negroiu, L F Robbers, A M Beek, O Kamp
BACKGROUND: We compared three-dimensional speckle tracking echocardiography (3DSTE) and its strain to cardiac magnetic resonance (CMR) with delayed contrast enhancement for left ventricular (LV) chamber quantification and transmurality of myocardial scar. Furthermore, we examined the ability of 3DSTE strain to differentiate between ischaemic and non-ischaemic LV dysfunction. METHODS: In 80 consecutive patients with ischaemic and 40 patients with non-ischaemic LV dysfunction, the correlations between LV volumes and ejection fraction were measured using 3DSTE and CMR...
October 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27538687/upgrade-rates-of-high-risk-breast-lesions-diagnosed-on-core-needle-biopsy-a-single-institution-experience-and-literature-review
#18
Kelly L Mooney, Lawrence W Bassett, Sophia K Apple
Optimal management of high-risk breast lesions detected by mammogram yielding atypical ductal hyperplasia, flat epithelial atypia, atypical lobular hyperplasia, lobular carcinoma in situ, and radial scar without atypia on core needle biopsy is controversial. This is a single-institution retrospective review of 5750 core needle biopsy cases seen over 14.5 years, including 249 (4.3%), 72 (1.3%), 50 (0.9%), 37 (0.6%), and 54 (0.9%) cases of atypical ductal hyperplasia, flat epithelial atypia, atypical lobular hyperplasia, lobular carcinoma in situ, and radial scar without atypia, respectively...
August 19, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27522516/first-international-consensus-conference-on-lesions-of-uncertain-malignant-potential-in-the-breast-b3-lesions
#19
REVIEW
Christoph J Rageth, Elizabeth Am O'Flynn, Christopher Comstock, Claudia Kurtz, Rahel Kubik, Helmut Madjar, Domenico Lepori, Gert Kampmann, Alexander Mundinger, Astrid Baege, Thomas Decker, Stefanie Hosch, Christoph Tausch, Jean-François Delaloye, Elisabeth Morris, Zsuzsanna Varga
The purpose of this study is to obtain a consensus for the therapy of B3 lesions. The first International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) including atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL), benign phyllodes tumors (PT), and radial scars (RS) took place in January 2016 in Zurich, Switzerland organized by the International Breast Ultrasound School and the Swiss Minimally Invasive Breast Biopsy group-a subgroup of the Swiss Society of Senology...
September 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27444865/mammographically-occult-asymptomatic-radial-scars-complex-sclerosing-lesions-at-ultrasonography-guided-core-needle-biopsy-follow-up-can-be-recommended
#20
Vivian Youngjean Park, Eun-Kyung Kim, Min Jung Kim, Jung Hyun Yoon, Hee Jung Moon
An increasing number of radial scars are detected by ultrasound (US), but their management is controversial. This study investigated the upgrade rate in mammographically occult radial scars/complex sclerosing lesions without epithelial atypia at US-guided 14-gauge core needle biopsy in asymptomatic patients. Nineteen mammographically occult benign radial scars/complex sclerosing lesions (median size, 7 mm; range, 3-23 mm) were included. Patients underwent surgical excision (n = 10) or vacuum-assisted excision, with follow-up US at least 6 mo after benign vacuum-assisted excision results (n = 8), or underwent US follow-up for 2 y after core needle biopsy (n = 1)...
October 2016: Ultrasound in Medicine & Biology
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