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Arman Eshaghi, Ferran Prados, Wallace Brownlee, Daniel R Altmann, Carmen Tur, M Jorge Cardoso, Floriana De Angelis, Steven H van de Pavert, Niamh Cawley, Nicola De Stefano, M Laura Stromillo, Marco Battaglini, Serena Ruggieri, Claudio Gasperini, Massimo Filippi, Maria A Rocca, Alex Rovira, Jaume Sastre-Garriga, Hugo Vrenken, Cyra E Leurs, Joep Killestein, Lukas Pirpamer, Christian Enzinger, Sebastien Ourselin, Claudia A M Gandini Wheeler-Kingshott, Declan Chard, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Olga Ciccarelli
OBJECTIVE: Grey matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. METHODS: We analysed 3,604 brain high-resolution T1-weighted MRI scans from 1,417 participants: 1,214 MS patients (253 clinically-isolated syndrome[CIS], 708 relapsing-remitting[RRMS], 128 secondary-progressive[SPMS], 125 primary-progressive[PPMS]), over an average follow-up of 2...
January 13, 2018: Annals of Neurology
Marloes Hj Hagens, Jessica Burggraaff, Iris D Kilsdonk, Serena Ruggieri, Sara Collorone, Rosa Cortese, Niamh Cawley, Emilia Sbardella, Michaela Andelova, Michael Amann, Johanna M Lieb, Patrizia Pantano, Birgit I Lissenberg-Witte, Joep Killestein, Celia Oreja-Guevara, Jens Wuerfel, Olga Ciccarelli, Claudio Gasperini, Carsten Lukas, Alex Rovira, Frederik Barkhof, Mike P Wattjes
BACKGROUND: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. OBJECTIVES: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. METHODS: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Massimo Filippi, Paolo Preziosa, Alessandro Meani, Olga Ciccarelli, Sarlota Mesaros, Alex Rovira, Jette Frederiksen, Christian Enzinger, Frederik Barkhof, Claudio Gasperini, Wallace Brownlee, Jelena Drulovic, Xavier Montalban, Stig P Cramer, Alexander Pichler, Marloes Hagens, Serena Ruggieri, Vittorio Martinelli, Katherine Miszkiel, Mar Tintorè, Giancarlo Comi, Iris Dekker, Bernard Uitdehaag, Irena Dujmovic-Basuroski, Maria A Rocca
BACKGROUND: In 2016, the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) network proposed modifications to the MRI criteria to define dissemination in space (DIS) and time (DIT) for the diagnosis of multiple sclerosis in patients with clinically isolated syndrome (CIS). Changes to the DIS definition included removal of the distinction between symptomatic and asymptomatic lesions, increasing the number of lesions needed to define periventricular involvement to three, combining cortical and juxtacortical lesions, and inclusion of optic nerve evaluation...
December 21, 2017: Lancet Neurology
Georgina Arrambide, Mar Tintore, Cristina Auger, Jordi Río, Joaquín Castilló, Angela Vidal-Jordana, Ingrid Galán, Carlos Nos, Manuel Comabella, Raquel Mitjana, Patricia Mulero, Andrea de Barros, Breogán Rodríguez-Acevedo, Luciana Midaglia, Jaume Sastre-Garriga, Alex Rovira, Xavier Montalban
OBJECTIVES: To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions in clinically isolated syndromes (CIS). METHODS: Step 1: We evaluated lesion topography classifications in 657 patients with CIS with stepwise Cox proportional hazards regression models considering second attack as the outcome. Step 2: We established 2 dissemination in space (DIS) versions according to the periventricular lesion cutoffs of ≥1 and ≥3 and assessed their performance at 10 years with second attack as the outcome, first individually and then combined with dissemination in time (DIT) in all cases (n = 326), by age, and by CIS topography...
December 5, 2017: Neurology
Alexandra de Sitter, Martijn D Steenwijk, Aurélie Ruet, Adriaan Versteeg, Yaou Liu, Ronald A van Schijndel, Petra J W Pouwels, Iris D Kilsdonk, Keith S Cover, Bob W van Dijk, Stefan Ropele, Maria A Rocca, Marios Yiannakas, Mike P Wattjes, Soheil Damangir, Giovanni B Frisoni, Jaume Sastre-Garriga, Alex Rovira, Christian Enzinger, Massimo Filippi, Jette Frederiksen, Olga Ciccarelli, Ludwig Kappos, Frederik Barkhof, Hugo Vrenken
BACKGROUND AND PURPOSE: In vivoidentification of white matter lesions plays a key-role in evaluation of patients with multiple sclerosis (MS). Automated lesion segmentation methods have been developed to substitute manual outlining, but evidence of their performance in multi-center investigations is lacking. In this work, five research-domain automated segmentation methods were evaluated using a multi-center MS dataset. METHODS: 70 MS patients (median EDSS of 2...
September 9, 2017: NeuroImage
V V Bryukhov, I A Krotenkova, S N Morozova, M V Krotenkova
Magnetic resonance imaging (MRI) is the primary method for confirming the clinical diagnosis of multiple sclerosis (MS). The article presents the current data on using MRI of the brain and spinal cord for diagnosis in suspected MS. Special attention is paid to the MRI criteria of McDonald and MAGNIMS for relapsing-remitting MS (RRMS) and primary-progressive MS (PPMS) in the latest revisions of 2010 and 2016. The information provided can help radiologists and neurologists to optimize the use of MRI in clinical practice for diagnosis of MS...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Jae-Won Hyun, So-Young Huh, Woojun Kim, Min Su Park, Suk-Won Ahn, Joong-Yang Cho, Byung-Jo Kim, Sang-Hyun Lee, Su-Hyun Kim, Ho Jin Kim
OBJECTIVES: We compared validity of 2010 McDonald and newly proposed 2016 Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) criteria for dissemination in space (DIS) in predicting the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). METHODS: Between 2006 and 2016, we enrolled 170 patients who had a first clinical event suggestive of multiple sclerosis (MS) from seven referral hospitals in Korea...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
Mario Habek, Ivan Adamec, Barbara Barun, Luka Crnošija, Tereza Gabelić, Magdalena Krbot Skorić
Different neurophysiological methods such as evoked potentials (EP), testing of the autonomic nervous system (ANS) or polysomnography have the potential to detect clinically silent lesions or to confirm the existence of an association between a clinical symptom and multiple sclerosis (MS); previously undetected by MRI. Therefore, in the most recent MRI criteria for the diagnosis of MS (MAGNIMS consensus guidelines), neurophysiological confirmation of optic nerve dysfunction (slowed conduction on visual EP), support dissemination in space and, in patients without concurrent visual symptoms, dissemination in time...
2017: Advances in Experimental Medicine and Biology
Wallace J Brownlee, Katherine A Miszkiel, Daniel R Altmann, Olga Ciccarelli, David H Miller
In patients who present with a clinically isolated syndrome (CIS), whose features are suggestive of multiple sclerosis (MS), fulfilling McDonald 2010 magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) and dissemination in time (DIT) enables a diagnosis of MS. While ⩾1 periventricular lesion is included in the 2010 DIS criteria, earlier McDonald criteria required ⩾3 periventricular lesions to confirm DIS and recent Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS)-recommended DIS criteria also require ⩾3 lesions...
June 2017: Multiple Sclerosis: Clinical and Laboratory Research
Maria Pia Sormani, Claudio Gasperini, Marzia Romeo, Jordi Rio, Massimiliano Calabrese, Eleonora Cocco, Christian Enzingher, Franz Fazekas, Massimo Filippi, Antonio Gallo, Ludwig Kappos, Maria Giovanna Marrosu, Vittorio Martinelli, Luca Prosperini, Maria Assunta Rocca, Alex Rovira, Till Sprenger, Maria Laura Stromillo, Gioacchino Tedeschi, Mar Tintorè, Carla Tortorella, Maria Trojano, Xavier Montalban, Carlo Pozzilli, Giancarlo Comi, Nicola De Stefano
OBJECTIVE: To provide new insights into the role of markers of response to interferon-β therapy in multiple sclerosis (MS) in a multicenter setting, focusing on the relevance of MRI lesions in combination with clinical variables. METHODS: A large multicenter clinical dataset was collected within the Magnetic Resonance Imaging in MS (MAGNIMS) network. This included a large cohort of patients with relapsing-remitting MS on interferon-β treatment, MRI and clinical assessments during the first year of treatment, and clinical follow-up of at least 2 additional years...
July 12, 2016: Neurology
Marisa Koini, Massimo Filippi, Maria A Rocca, Tarek Yousry, Olga Ciccarelli, Gioacchino Tedeschi, Antonio Gallo, Stefan Ropele, Paola Valsasina, Gianna Riccitelli, Dusan Damjanovic, Nils Muhlert, Laura Mancini, Franz Fazekas, Christian Enzinger
Purpose To study the concomitant use of structural and functional magnetic resonance (MR) imaging correlates to explain information processing speed (IPS) and executive function (EF) in multiple sclerosis (MS). Materials and Methods Local ethics committee approval was obtained at all sites for this prospective, multicenter study. All subjects provided written informed consent. Twenty-six patients with relapsing-remitting MS and 32 healthy control subjects from four centers underwent structural and functional MR imaging, including a go/no-go task and neuropsychological assessment...
September 2016: Radiology
Paolo Preziosa, Maria A Rocca, Elisabetta Pagani, Maria Laura Stromillo, Christian Enzinger, Antonio Gallo, Hanneke E Hulst, Matteo Atzori, Deborah Pareto, Gianna C Riccitelli, Massimiliano Copetti, Nicola De Stefano, Franz Fazekas, Alvino Bisecco, Frederik Barkhof, Tarek A Yousry, Maria J Arévalo, Massimo Filippi
In a multicenter setting, we applied voxel-based methods to different structural MR imaging modalities to define the relative contributions of focal lesions, normal-appearing white matter (NAWM), and gray matter (GM) damage and their regional distribution to cognitive deficits as well as impairment of specific cognitive domains in multiple sclerosis (MS) patients. Approval of the institutional review boards was obtained, together with written informed consent from all participants. Standardized neuropsychological assessment and conventional, diffusion tensor and volumetric brain MRI sequences were collected from 61 relapsing-remitting MS patients and 61 healthy controls (HC) from seven centers...
April 2016: Human Brain Mapping
Massimo Filippi, Maria A Rocca, Olga Ciccarelli, Nicola De Stefano, Nikos Evangelou, Ludwig Kappos, Alex Rovira, Jaume Sastre-Garriga, Mar Tintorè, Jette L Frederiksen, Claudio Gasperini, Jacqueline Palace, Daniel S Reich, Brenda Banwell, Xavier Montalban, Frederik Barkhof
In patients presenting with a clinically isolated syndrome, MRI can support and substitute clinical information in the diagnosis of multiple sclerosis by showing disease dissemination in space and time and by helping to exclude disorders that can mimic multiple sclerosis. MRI criteria were first included in the diagnostic work-up for multiple sclerosis in 2001, and since then several modifications to the criteria have been proposed in an attempt to simplify lesion-count models for showing disease dissemination in space, change the timing of MRI scanning to show dissemination in time, and increase the value of spinal cord imaging...
March 2016: Lancet Neurology
Christian Enzinger, Frederik Barkhof, Olga Ciccarelli, Massimo Filippi, Ludwig Kappos, Maria A Rocca, Stefan Ropele, Àlex Rovira, Torben Schneider, Nicola de Stefano, Hugo Vrenken, Claudia Wheeler-Kingshott, Jens Wuerfel, Franz Fazekas
MRI has become the most important paraclinical tool for diagnosing and monitoring patients with multiple sclerosis (MS). However, conventional MRI sequences are largely nonspecific in the pathology they reveal, and only provide a limited view of the complex morphological changes associated with MS. Nonconventional MRI techniques, such as magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI) promise to complement existing techniques by revealing more-specific information on microstructural tissue changes...
December 2015: Nature Reviews. Neurology
J M Tillema, H E Hulst, M A Rocca, H Vrenken, M D Steenwijk, D Damjanovic, C Enzinger, S Ropele, G Tedeschi, A Gallo, O Ciccarelli, A Rovira, X Montalban, N de Stefano, M L Stromillo, M Filippi, F Barkhof
OBJECTIVES: The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing-remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. METHODS: T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs)...
June 2016: Multiple Sclerosis: Clinical and Laboratory Research
Mike P Wattjes, Àlex Rovira, David Miller, Tarek A Yousry, Maria P Sormani, Maria P de Stefano, Mar Tintoré, Cristina Auger, Carmen Tur, Massimo Filippi, Maria A Rocca, Franz Fazekas, Ludwig Kappos, Chris Polman, Frederik Barkhof, Xavier Montalban
The role of MRI in the assessment of multiple sclerosis (MS) goes far beyond the diagnostic process. MRI techniques can be used as regular monitoring to help stage patients with MS and measure disease progression. MRI can also be used to measure lesion burden, thus providing useful information for the prediction of long-term disability. With the introduction of a new generation of immunomodulatory and/or immunosuppressive drugs for the treatment of MS, MRI also makes an important contribution to the monitoring of treatment, and can be used to determine baseline tissue damage and detect subsequent repair...
October 2015: Nature Reviews. Neurology
Àlex Rovira, Mike P Wattjes, Mar Tintoré, Carmen Tur, Tarek A Yousry, Maria P Sormani, Nicola De Stefano, Massimo Filippi, Cristina Auger, Maria A Rocca, Frederik Barkhof, Franz Fazekas, Ludwig Kappos, Chris Polman, David Miller, Xavier Montalban
The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over the past few years. Technical improvements and continuously emerging data from clinical trials and observational studies have contributed to the enhanced performance of this tool for achieving a prompt diagnosis in patients with MS. The aim of this article is to provide guidelines for the implementation of MRI of the brain and spinal cord in the diagnosis of patients who are suspected of having MS. These guidelines are based on an extensive review of the recent literature, as well as on the personal experience of the members of the MAGNIMS (Magnetic Resonance Imaging in MS) network...
August 2015: Nature Reviews. Neurology
Xavier Montalban
Diagnostic criteria for MS rely on the demonstration of CNS disease in space and time and in reasonable exclusion of other causes. Since McDonald 2001, in patients with a first attack, MRI may provide evidence of diagnosis for dissemination in space and time. The 2010 McDonald criteria selected the Magnims criteria for dissemination in space (DIS). DIS is defined as the presence of ≥1 asymptomatic T2 lesion(s) in at least two of four locations considered characteristic for MS in previous MRI criteria: juxtacortical, periventricular, infratentorial and spinal cord...
November 2014: Multiple Sclerosis and related Disorders
Alvino Bisecco, Maria A Rocca, Elisabetta Pagani, Laura Mancini, Christian Enzinger, Antonio Gallo, Hugo Vrenken, Maria Laura Stromillo, Massimiliano Copetti, David L Thomas, Franz Fazekas, Gioacchino Tedeschi, Frederik Barkhof, Nicola De Stefano, Massimo Filippi
In this multicenter study, we performed a tractography-based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Dual-echo, morphological and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing-remitting MS patients and 57 healthy controls from six European centers. Patients underwent an extensive neuropsychological assessment. Thalamic connectivity defined regions (CDRs) were segmented based on their cortical connectivity using diffusion tractography-based parcellation...
July 2015: Human Brain Mapping
Achim Gass, Maria A Rocca, Federica Agosta, Olga Ciccarelli, Declan Chard, Paola Valsasina, Jonathan C W Brooks, Antje Bischof, Philipp Eisele, Ludwig Kappos, Frederik Barkhof, Massimo Filippi
The spinal cord is a clinically important site that is affected by pathological changes in most patients with multiple sclerosis; however, imaging of the spinal cord with conventional MRI can be difficult. Improvements in MRI provide a major advantage for spinal cord imaging, with better signal-to-noise ratio and improved spatial resolution. Through the use of multiplanar MRI, identification of diffuse and focal changes in the whole spinal cord is now routinely possible. Corroborated by related histopathological analyses, several new techniques, such as magnetisation transfer, diffusion tension imaging, functional MRI, and proton magnetic resonance spectroscopy, can detect non-focal, spinal cord pathological changes in patients with multiple sclerosis...
April 2015: Lancet Neurology
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