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magnims ms

Wallace J Brownlee, Katherine A Miszkiel, Daniel R Altmann, Olga Ciccarelli, David H Miller
In patients who present with a clinically isolated syndrome (CIS), whose features are suggestive of multiple sclerosis (MS), fulfilling McDonald 2010 magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) and dissemination in time (DIT) enables a diagnosis of MS. While ⩾1 periventricular lesion is included in the 2010 DIS criteria, earlier McDonald criteria required ⩾3 periventricular lesions to confirm DIS and recent Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS)-recommended DIS criteria also require ⩾3 lesions...
September 6, 2016: Multiple Sclerosis: Clinical and Laboratory Research
Maria Pia Sormani, Claudio Gasperini, Marzia Romeo, Jordi Rio, Massimiliano Calabrese, Eleonora Cocco, Christian Enzingher, Franz Fazekas, Massimo Filippi, Antonio Gallo, Ludwig Kappos, Maria Giovanna Marrosu, Vittorio Martinelli, Luca Prosperini, Maria Assunta Rocca, Alex Rovira, Till Sprenger, Maria Laura Stromillo, Gioacchino Tedeschi, Mar Tintorè, Carla Tortorella, Maria Trojano, Xavier Montalban, Carlo Pozzilli, Giancarlo Comi, Nicola De Stefano
OBJECTIVE: To provide new insights into the role of markers of response to interferon-β therapy in multiple sclerosis (MS) in a multicenter setting, focusing on the relevance of MRI lesions in combination with clinical variables. METHODS: A large multicenter clinical dataset was collected within the Magnetic Resonance Imaging in MS (MAGNIMS) network. This included a large cohort of patients with relapsing-remitting MS on interferon-β treatment, MRI and clinical assessments during the first year of treatment, and clinical follow-up of at least 2 additional years...
July 12, 2016: Neurology
Marisa Koini, Massimo Filippi, Maria A Rocca, Tarek Yousry, Olga Ciccarelli, Gioacchino Tedeschi, Antonio Gallo, Stefan Ropele, Paola Valsasina, Gianna Riccitelli, Dusan Damjanovic, Nils Muhlert, Laura Mancini, Franz Fazekas, Christian Enzinger
Purpose To study the concomitant use of structural and functional magnetic resonance (MR) imaging correlates to explain information processing speed (IPS) and executive function (EF) in multiple sclerosis (MS). Materials and Methods Local ethics committee approval was obtained at all sites for this prospective, multicenter study. All subjects provided written informed consent. Twenty-six patients with relapsing-remitting MS and 32 healthy control subjects from four centers underwent structural and functional MR imaging, including a go/no-go task and neuropsychological assessment...
September 2016: Radiology
Paolo Preziosa, Maria A Rocca, Elisabetta Pagani, Maria Laura Stromillo, Christian Enzinger, Antonio Gallo, Hanneke E Hulst, Matteo Atzori, Deborah Pareto, Gianna C Riccitelli, Massimiliano Copetti, Nicola De Stefano, Franz Fazekas, Alvino Bisecco, Frederik Barkhof, Tarek A Yousry, Maria J Arévalo, Massimo Filippi
In a multicenter setting, we applied voxel-based methods to different structural MR imaging modalities to define the relative contributions of focal lesions, normal-appearing white matter (NAWM), and gray matter (GM) damage and their regional distribution to cognitive deficits as well as impairment of specific cognitive domains in multiple sclerosis (MS) patients. Approval of the institutional review boards was obtained, together with written informed consent from all participants. Standardized neuropsychological assessment and conventional, diffusion tensor and volumetric brain MRI sequences were collected from 61 relapsing-remitting MS patients and 61 healthy controls (HC) from seven centers...
April 2016: Human Brain Mapping
Massimo Filippi, Maria A Rocca, Olga Ciccarelli, Nicola De Stefano, Nikos Evangelou, Ludwig Kappos, Alex Rovira, Jaume Sastre-Garriga, Mar Tintorè, Jette L Frederiksen, Claudio Gasperini, Jacqueline Palace, Daniel S Reich, Brenda Banwell, Xavier Montalban, Frederik Barkhof
In patients presenting with a clinically isolated syndrome, MRI can support and substitute clinical information in the diagnosis of multiple sclerosis by showing disease dissemination in space and time and by helping to exclude disorders that can mimic multiple sclerosis. MRI criteria were first included in the diagnostic work-up for multiple sclerosis in 2001, and since then several modifications to the criteria have been proposed in an attempt to simplify lesion-count models for showing disease dissemination in space, change the timing of MRI scanning to show dissemination in time, and increase the value of spinal cord imaging...
March 2016: Lancet Neurology
Christian Enzinger, Frederik Barkhof, Olga Ciccarelli, Massimo Filippi, Ludwig Kappos, Maria A Rocca, Stefan Ropele, Àlex Rovira, Torben Schneider, Nicola de Stefano, Hugo Vrenken, Claudia Wheeler-Kingshott, Jens Wuerfel, Franz Fazekas
MRI has become the most important paraclinical tool for diagnosing and monitoring patients with multiple sclerosis (MS). However, conventional MRI sequences are largely nonspecific in the pathology they reveal, and only provide a limited view of the complex morphological changes associated with MS. Nonconventional MRI techniques, such as magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI) promise to complement existing techniques by revealing more-specific information on microstructural tissue changes...
December 2015: Nature Reviews. Neurology
J M Tillema, H E Hulst, M A Rocca, H Vrenken, M D Steenwijk, D Damjanovic, C Enzinger, S Ropele, G Tedeschi, A Gallo, O Ciccarelli, A Rovira, X Montalban, N de Stefano, M L Stromillo, M Filippi, F Barkhof
OBJECTIVES: The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing-remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. METHODS: T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs)...
June 2016: Multiple Sclerosis: Clinical and Laboratory Research
Mike P Wattjes, Àlex Rovira, David Miller, Tarek A Yousry, Maria P Sormani, Maria P de Stefano, Mar Tintoré, Cristina Auger, Carmen Tur, Massimo Filippi, Maria A Rocca, Franz Fazekas, Ludwig Kappos, Chris Polman, Frederik Barkhof, Xavier Montalban
The role of MRI in the assessment of multiple sclerosis (MS) goes far beyond the diagnostic process. MRI techniques can be used as regular monitoring to help stage patients with MS and measure disease progression. MRI can also be used to measure lesion burden, thus providing useful information for the prediction of long-term disability. With the introduction of a new generation of immunomodulatory and/or immunosuppressive drugs for the treatment of MS, MRI also makes an important contribution to the monitoring of treatment, and can be used to determine baseline tissue damage and detect subsequent repair...
October 2015: Nature Reviews. Neurology
Àlex Rovira, Mike P Wattjes, Mar Tintoré, Carmen Tur, Tarek A Yousry, Maria P Sormani, Nicola De Stefano, Massimo Filippi, Cristina Auger, Maria A Rocca, Frederik Barkhof, Franz Fazekas, Ludwig Kappos, Chris Polman, David Miller, Xavier Montalban
The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over the past few years. Technical improvements and continuously emerging data from clinical trials and observational studies have contributed to the enhanced performance of this tool for achieving a prompt diagnosis in patients with MS. The aim of this article is to provide guidelines for the implementation of MRI of the brain and spinal cord in the diagnosis of patients who are suspected of having MS. These guidelines are based on an extensive review of the recent literature, as well as on the personal experience of the members of the MAGNIMS (Magnetic Resonance Imaging in MS) network...
August 2015: Nature Reviews. Neurology
Xavier Montalban
Diagnostic criteria for MS rely on the demonstration of CNS disease in space and time and in reasonable exclusion of other causes. Since McDonald 2001, in patients with a first attack, MRI may provide evidence of diagnosis for dissemination in space and time. The 2010 McDonald criteria selected the Magnims criteria for dissemination in space (DIS). DIS is defined as the presence of ≥1 asymptomatic T2 lesion(s) in at least two of four locations considered characteristic for MS in previous MRI criteria: juxtacortical, periventricular, infratentorial and spinal cord...
November 2014: Multiple Sclerosis and related Disorders
Alvino Bisecco, Maria A Rocca, Elisabetta Pagani, Laura Mancini, Christian Enzinger, Antonio Gallo, Hugo Vrenken, Maria Laura Stromillo, Massimiliano Copetti, David L Thomas, Franz Fazekas, Gioacchino Tedeschi, Frederik Barkhof, Nicola De Stefano, Massimo Filippi
In this multicenter study, we performed a tractography-based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Dual-echo, morphological and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing-remitting MS patients and 57 healthy controls from six European centers. Patients underwent an extensive neuropsychological assessment. Thalamic connectivity defined regions (CDRs) were segmented based on their cortical connectivity using diffusion tractography-based parcellation...
July 2015: Human Brain Mapping
Achim Gass, Maria A Rocca, Federica Agosta, Olga Ciccarelli, Declan Chard, Paola Valsasina, Jonathan C W Brooks, Antje Bischof, Philipp Eisele, Ludwig Kappos, Frederik Barkhof, Massimo Filippi
The spinal cord is a clinically important site that is affected by pathological changes in most patients with multiple sclerosis; however, imaging of the spinal cord with conventional MRI can be difficult. Improvements in MRI provide a major advantage for spinal cord imaging, with better signal-to-noise ratio and improved spatial resolution. Through the use of multiplanar MRI, identification of diffuse and focal changes in the whole spinal cord is now routinely possible. Corroborated by related histopathological analyses, several new techniques, such as magnetisation transfer, diffusion tension imaging, functional MRI, and proton magnetic resonance spectroscopy, can detect non-focal, spinal cord pathological changes in patients with multiple sclerosis...
April 2015: Lancet Neurology
Maria A Rocca, Maria P Amato, Nicola De Stefano, Christian Enzinger, Jeroen J Geurts, Iris-K Penner, Alex Rovira, James F Sumowski, Paola Valsasina, Massimo Filippi
In patients with multiple sclerosis (MS), grey matter damage is widespread and might underlie many of the clinical symptoms, especially cognitive impairment. This relation between grey matter damage and cognitive impairment has been lent support by findings from clinical and MRI studies. However, many aspects of cognitive impairment in patients with MS still need to be characterised. Standardised neuropsychological tests that are easy to administer and sensitive to disease-related abnormalities are needed to gain a better understanding of the factors affecting cognitive performance in patients with MS than exists at present...
March 2015: Lancet Neurology
Lucy Matthews, Christian Enzinger, Franz Fazekas, Alex Rovira, Olga Ciccarelli, Maria Teresa Dotti, Massimo Filippi, Jette L Frederiksen, Antonio Giorgio, Wilhelm Küker, Carsten Lukas, Maria A Rocca, Nicola De Stefano, Ahmed Toosy, Tarek Yousry, Jacqueline Palace
BACKGROUND: Leber's hereditary optic neuropathy (LHON) and a multiple sclerosis (MS)-like illness appear to coexist 50 times more frequently than would be expected by chance. This association of LHON and MS (LMS) raises an important question about whether there could be a common pathophysiological mechanism involving mitochondrial dysfunction. OBJECTIVE: The primary aim was to define MRI features of LMS and LHON, and to assess the proportions of individuals displaying features typical of MS...
May 2015: Journal of Neurology, Neurosurgery, and Psychiatry
Maria A Rocca, Paola Valsasina, Hanneke E Hulst, Khaled Abdel-Aziz, Christian Enzinger, Antonio Gallo, Debora Pareto, Gianna Riccitelli, Nils Muhlert, Olga Ciccarelli, Frederik Barkhof, Franz Fazekas, Gioacchino Tedeschi, Maria J Arévalo, Massimo Filippi
In this multicenter study, we applied functional magnetic resonance imaging (fMRI) to define the functional correlates of cognitive dysfunction in patients with multiple sclerosis (MS). fMRI scans during the performance of the N-back task were acquired from 42 right-handed relapsing remitting (RR) MS patients and 52 sex-matched right-handed healthy controls, studied at six European sites using 3.0 Tesla scanners. Patients with at least two abnormal (<2 standard deviations from the normative values) neuropsychological tests at a standardized evaluation were considered cognitively impaired (CI)...
December 2014: Human Brain Mapping
So-Young Huh, Ju-Hong Min, Woojun Kim, Su-Hyun Kim, Ho Jin Kim, Byung-Jo Kim, Byoung Joon Kim, Kwang Ho Lee
BACKGROUND: Although neuromyelitis optica (NMO) is a central nervous system (CNS) autoimmune disease distinct from multiple sclerosis (MS). NMO and NMO spectrum disorder (NMOSD) sometimes show asymptomatic lesions on brain magnetic resonance imaging (MRI) at onset, and even present with symptomatic brain involvement. OBJECTIVES: We investigated whether brain MRI at onset can be helpful for the differentiation of MS and NMOSD. METHODS: We retrospectively analyzed initial brain MRIs, performed within three months of onset, in patients with MS (n = 51) and anti-aquaporin4-antibody-positive patients with NMOSD (n = 67)...
May 2014: Multiple Sclerosis: Clinical and Laboratory Research
H Kearney, M A Rocca, P Valsasina, L Balk, J Sastre-Garriga, J Reinhardt, S Ruggieri, A Rovira, C Stippich, L Kappos, T Sprenger, P Tortorella, M Rovaris, C Gasperini, X Montalban, J J G Geurts, C H Polman, F Barkhof, M Filippi, D R Altmann, O Ciccarelli, D H Miller, D T Chard
BACKGROUND: Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it is relevant to how we monitor and treat the disease. OBJECTIVES: The Magnetic Imaging in MS (MAGNIMS) collaborative group sought to determine the relationship of brain lesion load, and brain and spinal cord atrophy, with physical disability in patients with long-established MS. METHODS: Patients had a magnetic resonance imaging (MRI) scan of their brain and spinal cord, from which we determined brain grey (GMF) and white matter (WMF) fractional volumes, upper cervical spinal cord cross-sectional area (UCCA) and brain T2-lesion volume (T2LV)...
January 2014: Multiple Sclerosis: Clinical and Laboratory Research
Veronica Popescu, Federica Agosta, Hanneke E Hulst, Ingrid C Sluimer, Dirk L Knol, Maria Pia Sormani, Christian Enzinger, Stefan Ropele, Julio Alonso, Jaume Sastre-Garriga, Alex Rovira, Xavier Montalban, Benedetta Bodini, Olga Ciccarelli, Zhaleh Khaleeli, Declan T Chard, Lucy Matthews, Jaqueline Palace, Antonio Giorgio, Nicola De Stefano, Philipp Eisele, Achim Gass, Chris H Polman, Bernard M J Uitdehaag, Maria Jose Messina, Giancarlo Comi, Massimo Filippi, Frederik Barkhof, Hugo Vrenken
OBJECTIVE: To determine whether brain atrophy and lesion volumes predict subsequent 10 year clinical evolution in multiple sclerosis (MS). DESIGN: From eight MAGNIMS (MAGNetic resonance Imaging in MS) centres, we retrospectively included 261 MS patients with MR imaging at baseline and after 1-2 years, and Expanded Disability Status Scale (EDSS) scoring at baseline and after 10 years. Annualised whole brain atrophy, central brain atrophy rates and T2 lesion volumes were calculated...
October 2013: Journal of Neurology, Neurosurgery, and Psychiatry
H Vrenken, M Jenkinson, M A Horsfield, M Battaglini, R A van Schijndel, E Rostrup, J J G Geurts, E Fisher, A Zijdenbos, J Ashburner, D H Miller, M Filippi, F Fazekas, M Rovaris, A Rovira, F Barkhof, N de Stefano
Focal lesions and brain atrophy are the most extensively studied aspects of multiple sclerosis (MS), but the image acquisition and analysis techniques used can be further improved, especially those for studying within-patient changes of lesion load and atrophy longitudinally. Improved accuracy and sensitivity will reduce the numbers of patients required to detect a given treatment effect in a trial, and ultimately, will allow reliable characterization of individual patients for personalized treatment. Based on open issues in the field of MS research, and the current state of the art in magnetic resonance image analysis methods for assessing brain lesion load and atrophy, this paper makes recommendations to improve these measures for longitudinal studies of MS...
October 2013: Journal of Neurology
Antonio Giorgio, Marco Battaglini, Maria Assunta Rocca, Alessandro De Leucio, Martina Absinta, Ronald van Schijndel, Alex Rovira, Mar Tintoré, Declan Chard, Olga Ciccarelli, Christian Enzinger, Claudio Gasperini, Jette Frederiksen, Massimo Filippi, Frederik Barkhof, Nicola De Stefano
OBJECTIVES: To assess in a large population of patients with clinically isolated syndrome (CIS) the relevance of brain lesion location and frequency in predicting 1-year conversion to multiple sclerosis (MS). METHODS: In this multicenter, retrospective study, clinical and MRI data at onset and clinical follow-up at 1 year were collected for 1,165 patients with CIS. On T2-weighted MRI, we generated lesion probability maps of white matter (WM) lesion location and frequency...
January 15, 2013: Neurology
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