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https://www.readbyqxmd.com/read/29741648/progression-of-regional-grey-matter-atrophy-in-multiple-sclerosis
#1
Arman Eshaghi, Razvan V Marinescu, Alexandra L Young, Nicholas C Firth, Ferran Prados, M Jorge Cardoso, Carmen Tur, Floriana De Angelis, Niamh Cawley, Wallace J Brownlee, Nicola De Stefano, M Laura Stromillo, Marco Battaglini, Serena Ruggieri, Claudio Gasperini, Massimo Filippi, Maria A Rocca, Alex Rovira, Jaume Sastre-Garriga, Jeroen J G Geurts, Hugo Vrenken, Viktor Wottschel, Cyra E Leurs, Bernard Uitdehaag, Lukas Pirpamer, Christian Enzinger, Sebastien Ourselin, Claudia A Gandini Wheeler-Kingshott, Declan Chard, Alan J Thompson, Frederik Barkhof, Daniel C Alexander, Olga Ciccarelli
Grey matter atrophy is present from the earliest stages of multiple sclerosis, but its temporal ordering is poorly understood. We aimed to determine the sequence in which grey matter regions become atrophic in multiple sclerosis and its association with disability accumulation. In this longitudinal study, we included 1417 subjects: 253 with clinically isolated syndrome, 708 with relapsing-remitting multiple sclerosis, 128 with secondary-progressive multiple sclerosis, 125 with primary-progressive multiple sclerosis, and 203 healthy control subjects from seven European centres...
May 8, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29714673/measurement-of-whole-brain-and-gray-matter-atrophy-in-multiple-sclerosis-assessment-with-mr-imaging
#2
Loredana Storelli, Maria A Rocca, Elisabetta Pagani, Wim Van Hecke, Mark A Horsfield, Nicola De Stefano, Alex Rovira, Jaume Sastre-Garriga, Jacqueline Palace, Diana Sima, Dirk Smeets, Massimo Filippi
Purpose To compare available methods for whole-brain and gray matter (GM) atrophy estimation in multiple sclerosis (MS) in terms of repeatability (same magnetic resonance [MR] imaging unit) and reproducibility (different system/field strength) for their potential clinical applications. Materials and Methods The softwares ANTs-v1.9, CIVET-v2.1, FSL-SIENAX/SIENA-5.0.1, Icometrix-MSmetrix-1.7, and SPM-v12 were compared. This retrospective study, performed between March 2015 and March 2017, collected data from (a) eight simulated MR images and longitudinal data (2 weeks) from 10 healthy control subjects to assess the cross-sectional and longitudinal accuracy of atrophy measures, (b) test-retest MR images in 29 patients with MS acquired within the same day at different imaging unit field strengths/manufacturers to evaluate precision, and (c) longitudinal data (1 year) in 24 patients with MS for the agreement between methods...
May 27, 2018: Radiology
https://www.readbyqxmd.com/read/29582852/the-current-role-of-mri-in-differentiating-multiple-sclerosis-from-its-imaging-mimics
#3
Ruth Geraldes, Olga Ciccarelli, Frederik Barkhof, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Monika Hofer, Friedemann Paul, Paolo Preziosa, Alex Rovira, Gabriele C DeLuca, Ludwig Kappos, Tarek Yousry, Franz Fazekas, Jette Frederiksen, Claudio Gasperini, Jaume Sastre-Garriga, Nikos Evangelou
This corrects the article DOI: 10.1038/nrneurol.2018.14.
March 20, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29521337/the-current-role-of-mri-in-differentiating-multiple-sclerosis-from-its-imaging-mimics
#4
REVIEW
Ruth Geraldes, Olga Ciccarelli, Frederik Barkhof, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Monika Hofer, Friedemann Paul, Paolo Preziosa, Alex Rovira, Gabriele C DeLuca, Ludwig Kappos, Tarek Yousry, Franz Fazekas, Jette Frederiksen, Claudio Gasperini, Jaume Sastre-Garriga, Nikos Evangelou, Jacqueline Palace
MRI red flags proposed over a decade ago by the European Magnetic Resonance Network in MS (MAGNIMS) have guided clinicians in the diagnosis of multiple sclerosis (MS). However, the past 10 years have seen increased recognition that vascular disease can coexist and possibly interact with MS, improvements in the reliability of ways to differentiate MS from novel antibody-mediated CNS disorders (such as anti-aquaporin-4 antibody and myelin-oligodendrocyte glycoprotein antibody-associated diseases) and advances in MRI techniques...
April 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29511382/management-of-multiple-sclerosis-patients-in-central-european-countries-current-needs-and-potential-solutions
#5
REVIEW
Thomas Berger, Monika Adamczyk-Sowa, Tünde Csépány, Franz Fazekas, Tanja Hojs Fabjan, Dana Horáková, Zsolt Illes, Eleonóra Klimová, Fritz Leutmezer, Konrad Rejdak, Csilla Rozsa, Saša Šega Jazbec, Jarmila Szilasiová, Peter Turčáni, Marta Vachová, László Vécsei, Eva Havrdová
Multiple sclerosis (MS) experts in Europe are facing rapidly rising demands of excellence due to the increasing complexity of MS therapy and management. A central European expert board of MS experts met to identify needs and obstacles with respect to raising quality of MS care in central and Eastern European countries. There are substantial variations across countries regarding delivery of care and its cost structure, as well as access to treatment. To date, Eastern European countries are often less able to afford reimbursement of immunomodulatory agents than Western countries...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29477616/the-role-of-the-cerebellum-in-multiple-sclerosis-150-years-after-charcot
#6
REVIEW
Katrin Parmar, Christine Stadelmann, Maria A Rocca, Dawn Langdon, Egidio D'Angelo, Marcus D'Souza, Jessica Burggraaff, Christiane Wegner, Jaume Sastre-Garriga, Alonso Barrantes-Freer, Jonas Dorn, Bernard M J Uitdehaag, Xavier Montalban, Jens Wuerfel, Christian Enzinger, Alex Rovira, Mar Tintore, Massimo Filippi, Ludwig Kappos, Till Sprenger
Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging...
June 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29451440/radiologically-isolated-syndrome-or-subclinical-multiple-sclerosis-magnims-consensus-recommendations
#7
Nicola De Stefano, Antonio Giorgio, Mar Tintoré, Maria Pia Amato, Ludwig Kappos, Jacqueline Palace, Tarek Yousry, Maria A Rocca, Olga Ciccarelli, Christian Enzinger, Jette Frederiksen, Massimo Filippi, Hugo Vrenken, Àlex Rovira
No abstract text is available yet for this article.
February 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29331092/deep-gray-matter-volume-loss-drives-disability-worsening-in-multiple-sclerosis
#8
Arman Eshaghi, Ferran Prados, Wallace J Brownlee, Daniel R Altmann, Carmen Tur, M Jorge Cardoso, Floriana De Angelis, Steven H van de Pavert, Niamh Cawley, Nicola De Stefano, M Laura Stromillo, Marco Battaglini, Serena Ruggieri, Claudio Gasperini, Massimo Filippi, Maria A Rocca, Alex Rovira, Jaume Sastre-Garriga, Hugo Vrenken, Cyra E Leurs, Joep Killestein, Lukas Pirpamer, Christian Enzinger, Sebastien Ourselin, Claudia A M Gandini Wheeler-Kingshott, Declan Chard, Alan J Thompson, Daniel C Alexander, Frederik Barkhof, Olga Ciccarelli
OBJECTIVE: Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. METHODS: We analyzed 3,604 brain high-resolution T1-weighted magnetic resonance imaging scans from 1,417 participants: 1,214 MS patients (253 clinically isolated syndrome [CIS], 708 relapsing-remitting [RRMS], 128 secondary-progressive [SPMS], and 125 primary-progressive [PPMS]), over an average follow-up of 2...
February 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29327668/impact-of-3-tesla-mri-on-interobserver-agreement-in-clinically-isolated-syndrome-a-magnims-multicentre-study
#9
Marloes Hj Hagens, Jessica Burggraaff, Iris D Kilsdonk, Serena Ruggieri, Sara Collorone, Rosa Cortese, Niamh Cawley, Emilia Sbardella, Michaela Andelova, Michael Amann, Johanna M Lieb, Patrizia Pantano, Birgit I Lissenberg-Witte, Joep Killestein, Celia Oreja-Guevara, Jens Wuerfel, Olga Ciccarelli, Claudio Gasperini, Carsten Lukas, Alex Rovira, Frederik Barkhof, Mike P Wattjes
BACKGROUND: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. OBJECTIVES: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. METHODS: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29275979/prediction-of-a-multiple-sclerosis-diagnosis-in-patients-with-clinically-isolated-syndrome-using-the-2016-magnims-and-2010-mcdonald-criteria-a-retrospective-study
#10
Massimo Filippi, Paolo Preziosa, Alessandro Meani, Olga Ciccarelli, Sarlota Mesaros, Alex Rovira, Jette Frederiksen, Christian Enzinger, Frederik Barkhof, Claudio Gasperini, Wallace Brownlee, Jelena Drulovic, Xavier Montalban, Stig P Cramer, Alexander Pichler, Marloes Hagens, Serena Ruggieri, Vittorio Martinelli, Katherine Miszkiel, Mar Tintorè, Giancarlo Comi, Iris Dekker, Bernard Uitdehaag, Irena Dujmovic-Basuroski, Maria A Rocca
BACKGROUND: In 2016, the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) network proposed modifications to the MRI criteria to define dissemination in space (DIS) and time (DIT) for the diagnosis of multiple sclerosis in patients with clinically isolated syndrome (CIS). Changes to the DIS definition included removal of the distinction between symptomatic and asymptomatic lesions, increasing the number of lesions needed to define periventricular involvement to three, combining cortical and juxtacortical lesions, and inclusion of optic nerve evaluation...
February 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29101276/lesion-topographies-in-multiple-sclerosis-diagnosis-a-reappraisal
#11
Georgina Arrambide, Mar Tintore, Cristina Auger, Jordi Río, Joaquín Castilló, Angela Vidal-Jordana, Ingrid Galán, Carlos Nos, Manuel Comabella, Raquel Mitjana, Patricia Mulero, Andrea de Barros, Breogán Rodríguez-Acevedo, Luciana Midaglia, Jaume Sastre-Garriga, Alex Rovira, Xavier Montalban
OBJECTIVES: To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions in clinically isolated syndromes (CIS). METHODS: Step 1: We evaluated lesion topography classifications in 657 patients with CIS with stepwise Cox proportional hazards regression models considering second attack as the outcome. Step 2: We established 2 dissemination in space (DIS) versions according to the periventricular lesion cutoffs of ≥1 and ≥3 and assessed their performance at 10 years with second attack as the outcome, first individually and then combined with dissemination in time (DIT) in all cases (n = 326), by age, and by CIS topography...
December 5, 2017: Neurology
https://www.readbyqxmd.com/read/28899746/performance-of-five-research-domain-automated-wm-lesion-segmentation-methods-in-a-multi-center-ms-study
#12
Alexandra de Sitter, Martijn D Steenwijk, Aurélie Ruet, Adriaan Versteeg, Yaou Liu, Ronald A van Schijndel, Petra J W Pouwels, Iris D Kilsdonk, Keith S Cover, Bob W van Dijk, Stefan Ropele, Maria A Rocca, Marios Yiannakas, Mike P Wattjes, Soheil Damangir, Giovanni B Frisoni, Jaume Sastre-Garriga, Alex Rovira, Christian Enzinger, Massimo Filippi, Jette Frederiksen, Olga Ciccarelli, Ludwig Kappos, Frederik Barkhof, Hugo Vrenken
BACKGROUND AND PURPOSE: In vivoidentification of white matter lesions plays a key-role in evaluation of patients with multiple sclerosis (MS). Automated lesion segmentation methods have been developed to substitute manual outlining, but evidence of their performance in multi-center investigations is lacking. In this work, five research-domain automated segmentation methods were evaluated using a multi-center MS dataset. METHODS: 70 MS patients (median EDSS of 2...
December 2017: NeuroImage
https://www.readbyqxmd.com/read/28617364/-a-current-view-on-the-mri-diagnosis-of-multiple-sclerosis-an-update-of-2016-revised-mri-criteria
#13
V V Bryukhov, I A Krotenkova, S N Morozova, M V Krotenkova
Magnetic resonance imaging (MRI) is the primary method for confirming the clinical diagnosis of multiple sclerosis (MS). The article presents the current data on using MRI of the brain and spinal cord for diagnosis in suspected MS. Special attention is paid to the MRI criteria of McDonald and MAGNIMS for relapsing-remitting MS (RRMS) and primary-progressive MS (PPMS) in the latest revisions of 2010 and 2016. The information provided can help radiologists and neurologists to optimize the use of MRI in clinical practice for diagnosis of MS...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28492101/evaluation-of-2016-magnims-mri-criteria-for-dissemination-in-space-in-patients-with-a-clinically-isolated-syndrome
#14
Jae-Won Hyun, So-Young Huh, Woojun Kim, Min Su Park, Suk-Won Ahn, Joong-Yang Cho, Byung-Jo Kim, Sang-Hyun Lee, Su-Hyun Kim, Ho Jin Kim
OBJECTIVES: We compared validity of 2010 McDonald and newly proposed 2016 Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) criteria for dissemination in space (DIS) in predicting the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). METHODS: Between 2006 and 2016, we enrolled 170 patients who had a first clinical event suggestive of multiple sclerosis (MS) from seven referral hospitals in Korea...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28093711/clinical-neurophysiology-of-multiple-sclerosis
#15
REVIEW
Mario Habek, Ivan Adamec, Barbara Barun, Luka Crnošija, Tereza Gabelić, Magdalena Krbot Skorić
Different neurophysiological methods such as evoked potentials (EP), testing of the autonomic nervous system (ANS) or polysomnography have the potential to detect clinically silent lesions or to confirm the existence of an association between a clinical symptom and multiple sclerosis (MS); previously undetected by MRI. Therefore, in the most recent MRI criteria for the diagnosis of MS (MAGNIMS consensus guidelines), neurophysiological confirmation of optic nerve dysfunction (slowed conduction on visual EP), support dissemination in space and, in patients without concurrent visual symptoms, dissemination in time...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27600111/periventricular-lesions-and-ms-diagnostic-criteria-in-young-adults-with-typical-clinically-isolated-syndromes
#16
Wallace J Brownlee, Katherine A Miszkiel, Daniel R Altmann, Olga Ciccarelli, David H Miller
In patients who present with a clinically isolated syndrome (CIS), whose features are suggestive of multiple sclerosis (MS), fulfilling McDonald 2010 magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) and dissemination in time (DIT) enables a diagnosis of MS. While ⩾1 periventricular lesion is included in the 2010 DIS criteria, earlier McDonald criteria required ⩾3 periventricular lesions to confirm DIS and recent Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS)-recommended DIS criteria also require ⩾3 lesions...
June 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27306626/assessing-response-to-interferon-%C3%AE-in-a-multicenter-dataset-of-patients-with-ms
#17
MULTICENTER STUDY
Maria Pia Sormani, Claudio Gasperini, Marzia Romeo, Jordi Rio, Massimiliano Calabrese, Eleonora Cocco, Christian Enzingher, Franz Fazekas, Massimo Filippi, Antonio Gallo, Ludwig Kappos, Maria Giovanna Marrosu, Vittorio Martinelli, Luca Prosperini, Maria Assunta Rocca, Alex Rovira, Till Sprenger, Maria Laura Stromillo, Gioacchino Tedeschi, Mar Tintorè, Carla Tortorella, Maria Trojano, Xavier Montalban, Carlo Pozzilli, Giancarlo Comi, Nicola De Stefano
OBJECTIVE: To provide new insights into the role of markers of response to interferon-β therapy in multiple sclerosis (MS) in a multicenter setting, focusing on the relevance of MRI lesions in combination with clinical variables. METHODS: A large multicenter clinical dataset was collected within the Magnetic Resonance Imaging in MS (MAGNIMS) network. This included a large cohort of patients with relapsing-remitting MS on interferon-β treatment, MRI and clinical assessments during the first year of treatment, and clinical follow-up of at least 2 additional years...
July 12, 2016: Neurology
https://www.readbyqxmd.com/read/27002420/correlates-of-executive-functions-in-multiple-sclerosis-based-on-structural-and-functional-mr-imaging-insights-from-a-multicenter-study
#18
MULTICENTER STUDY
Marisa Koini, Massimo Filippi, Maria A Rocca, Tarek Yousry, Olga Ciccarelli, Gioacchino Tedeschi, Antonio Gallo, Stefan Ropele, Paola Valsasina, Gianna Riccitelli, Dusan Damjanovic, Nils Muhlert, Laura Mancini, Franz Fazekas, Christian Enzinger
Purpose To study the concomitant use of structural and functional magnetic resonance (MR) imaging correlates to explain information processing speed (IPS) and executive function (EF) in multiple sclerosis (MS). Materials and Methods Local ethics committee approval was obtained at all sites for this prospective, multicenter study. All subjects provided written informed consent. Twenty-six patients with relapsing-remitting MS and 32 healthy control subjects from four centers underwent structural and functional MR imaging, including a go/no-go task and neuropsychological assessment...
September 2016: Radiology
https://www.readbyqxmd.com/read/26833969/structural-mri-correlates-of-cognitive-impairment-in-patients-with-multiple-sclerosis-a-multicenter-study
#19
MULTICENTER STUDY
Paolo Preziosa, Maria A Rocca, Elisabetta Pagani, Maria Laura Stromillo, Christian Enzinger, Antonio Gallo, Hanneke E Hulst, Matteo Atzori, Deborah Pareto, Gianna C Riccitelli, Massimiliano Copetti, Nicola De Stefano, Franz Fazekas, Alvino Bisecco, Frederik Barkhof, Tarek A Yousry, Maria J Arévalo, Massimo Filippi
In a multicenter setting, we applied voxel-based methods to different structural MR imaging modalities to define the relative contributions of focal lesions, normal-appearing white matter (NAWM), and gray matter (GM) damage and their regional distribution to cognitive deficits as well as impairment of specific cognitive domains in multiple sclerosis (MS) patients. Approval of the institutional review boards was obtained, together with written informed consent from all participants. Standardized neuropsychological assessment and conventional, diffusion tensor and volumetric brain MRI sequences were collected from 61 relapsing-remitting MS patients and 61 healthy controls (HC) from seven centers...
April 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/26822746/mri-criteria-for-the-diagnosis-of-multiple-sclerosis-magnims-consensus-guidelines
#20
REVIEW
Massimo Filippi, Maria A Rocca, Olga Ciccarelli, Nicola De Stefano, Nikos Evangelou, Ludwig Kappos, Alex Rovira, Jaume Sastre-Garriga, Mar Tintorè, Jette L Frederiksen, Claudio Gasperini, Jacqueline Palace, Daniel S Reich, Brenda Banwell, Xavier Montalban, Frederik Barkhof
In patients presenting with a clinically isolated syndrome, MRI can support and substitute clinical information in the diagnosis of multiple sclerosis by showing disease dissemination in space and time and by helping to exclude disorders that can mimic multiple sclerosis. MRI criteria were first included in the diagnostic work-up for multiple sclerosis in 2001, and since then several modifications to the criteria have been proposed in an attempt to simplify lesion-count models for showing disease dissemination in space, change the timing of MRI scanning to show dissemination in time, and increase the value of spinal cord imaging...
March 2016: Lancet Neurology
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