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e_cadherin expression of gastric cancer

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https://www.readbyqxmd.com/read/27904778/long-non-coding-rna-ccat2-promotes-gastric-cancer-proliferation-and-invasion-by-regulating-the-e-cadherin-and-lats2
#1
Yong-Jun Wang, Jian-Zhen Liu, Pei Lv, Yi Dang, Jiang-Yan Gao, Yong Wang
Dysregulation of long non-coding RNAs (lncRNAs) play important roles in tumor development and progression. The long non-coding RNA CCAT2 has been identified to be up-regulated in gastric cancer (GC). However, the detailed molecular mechanism of CCAT2 involved in GC progression is still unknown. The aim of this study was to explore the expression and role of CCAT2 in GC progression. In the study, the expression levels of CCAT2 were significantly up-regulated in 108 cases GC tissues compared with adjacent non-tumor tissues by qRT-PCR analysis...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27904681/mir-330-3p-inhibits-gastric-cancer-progression-through-targeting-msi1
#2
Aoran Guan, Hui Wang, Xun Li, Hui Xie, Ruotian Wang, Yankun Zhu, Ruhong Li
Increasing evidences demonstrated that microRNAs (miRNAs) play critical roles in the human tumor development and progression. In our study, we found that miR-330-3p expression was downregulated in gastric cancer cell lines and tissues. Ectopic expression of miR-330-3p suppressed the gastric cancer cell proliferation, colony formation and migration. Overexpression of miR-330-3p promoted E-cadherin expression and inhibited the expression of N-cadherin, vimentin and snail. We identified Musashi-1 (MSI1) as a direct target gene of miR-330-3p in gastric cancer cell...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27900025/pbx3-promotes-gastric-cancer-invasion-and-metastasis-by-inducing-epithelial-mesenchymal-transition
#3
Shuanhu Wang, Chenglong Li, Wenbin Wang, Chungen Xing
The overexpression of pre-leukemia transcription factor 3 (PBX3) in tumors plays an important role in invasion, metastasis and proliferation in a variety of human cancer types. Tumor metastasis and angiogenesis significantly contribute to the progression of cancer and create challenges for cancer therapy. In the present study, reverse transcription-polymerase chain reaction demonstrated that PBX3 was upregulated in gastric cancer (GC) tissues and Transwell assay revealed that the overexpression of PBX3 promoted GC invasion and metastasis in vitro...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899979/aspirin-inhibits-the-proliferation-and-migration-of-gastric-cancer-cells-in-p53-knockout-mice
#4
Xue-Fu Li, Bing-Zhong Xu, Shi-Zhen Wang
The aim of the present study was to investigate the effect of aspirin on the cell proliferation and migration of gastric cancer cells in p53-knockout mice. Twenty p53(-/-) male mice aged 6 to 7 weeks, with an average weight of 20±3 g were used. The model of gastric cancer was established by the implantation of a mouse forestomach carcinoma cell line, subcutaneously, at the back of the neck, and then the mice were randomly divided into two groups after establishment of the model (control group, n=10; experimental group, n=10)...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27882939/direct-regulation-of-foxk1-by-c-jun-promotes-proliferation-invasion-and-metastasis-in-gastric-cancer-cells
#5
Ying Peng, Pei Zhang, Xiaoting Huang, Qingqing Yan, Meiyan Wu, Ruyi Xie, Yao Wu, Mengnan Zhang, Qingzhen Nan, Jinjun Zhao, Aimin Li, Jing Xiong, Yuexin Ren, Yang Bai, Ye Chen, Side Liu, Jide Wang
Forkhead box (FOX) K1 is a member of the FOX transcription factor superfamily. High FOXK1 expression is associated with several cancers. However, whether FOXK1 expression contributes to gastric cancer (GC) development and progression remains unknown. We analyzed the FOXK1 promoter using the Promo software and found several binding sequence transcription factors, including c-jun. However, the molecular mechanism by which FOXK1 affects the c-jun-mediated malignant phenotype is poorly understood. Here, we found that FOXK1 protein expression was higher in 8/10 (80...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27876712/mir-30a-decreases-multidrug-resistance-mdr-of-gastric-cancer-cells
#6
Chunying Li, Jinhai Zou, Guoqi Zheng, Jiankun Chu
BACKGROUND The effectiveness of chemotherapy for gastric cancer is largely limited by either intrinsic or acquired drug resistance. In this study, we aimed to explore the association between miR-30a dysregulation and multidrug resistance (MDR) in gastric cancer cells. MATERIAL AND METHODS We recruited 20 patients with advanced gastric cancer. Chemosensitivity was assessed after completion of the chemotherapy. SGC-7901 and SGC-7901/DDP cells were transfected for miR-30a overexpression or knockdown. Then, MTT assay was performed to assess the IC50 of DPP and 5-FU in SGC-7901 and SGC-7901/DDP cells...
November 23, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27861150/digital-pcr-identifies-changes-in-cdh1-e-cadherin-transcription-pattern-in-intestinal-type-gastric-cancer
#7
Raefa Abou Khouzam, Chiara Molinari, Samanta Salvi, Monica Marabelli, Valeria Molinaro, Donata Orioli, Luca Saragoni, Paolo Morgagni, Daniele Calistri, Guglielmina Nadia Ranzani
E-cadherin is a cell-cell adhesion protein encoded by CDH1 tumor-suppressor gene. CDH1 inactivating mutations, leading to loss of protein expression, are common in gastric cancer of the diffuse histotype, while alternative mechanisms modulating E-cadherin expression characterize the more common intestinal histotype. These mechanisms are still poorly understood. CDH1 intron 2 has recently emerged as a cis-modulator of E-cadherin expression, encoding non-canonical transcripts. One in particular, CDH1a, proved to be expressed in gastric cancer cell lines, while being absent in the normal stomach...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27855404/knockdown-of-radixin-suppresses-gastric-cancer-metastasis-in-vitro-by-up-regulation-of-e-cadherin-via-nf-%C3%AE%C2%BAb-snail-pathway
#8
Yu-Wen Zhu, Jun-Kai Yan, Juan-Juan Li, Yang-Ming Ou, Qing Yang
BACKGROUND/AIMS: Radixin has recently been shown to correlate with the metastasis of gastric cancer, but the pathogenesis is elusive. Adhesion proteins contribute to the regulation of metastasis, and thus this study sought to investigate the role of radixin in the migration, invasion and adhesion of gastric cancer cells, as well as its interaction with adhesion proteins in vitro. METHODS: Radixin stable knockdown human gastric carcinoma SGC-7901 cells were constructed...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27835600/yap1-enhances-cell-proliferation-migration-and-invasion-of-gastric-cancer-in-vitro-and-in-vivo
#9
Dan Sun, Xiaoting Li, Yingjian He, Wenhui Li, Ying Wang, Huan Wang, Shanshan Jiang, Yan Xin
Yes-associated protein 1 (YAP1) plays an important role in the development of carcinomas such as breast, colorectal, and gastric (GC) cancers, but the role of YAP1 in GC has not been investigated comprehensively. The present study strongly suggests that YAP1 and P62 were significantly up-regulated in GC specimens, compared with normal gastric mucosa. In addition, the YAP1high P62high expression was independently associated with poor prognosis in GC (hazard ratio: 1.334, 95% confidence interval: 1.045-1.704, P = 0...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27819872/high-throughput-protein-and-mrna-expression-based-classification-of-gastric-cancers-can-identify-clinically-distinct-subtypes-concordant-with-recent-molecular-classifications
#10
Sangjeong Ahn, So-Jeong Lee, Yonugkeum Kim, Ahrong Kim, Nari Shin, Kyung Un Choi, Chang-Hun Lee, Gi Yeong Huh, Kyong-Mee Kim, Namrata Setia, Gregory Y Lauwers, Do Youn Park
Gastric cancers have recently been classified into several types on the basis of molecular characterization, and the new taxonomy has shown to have clinical relevance. However, the technology required for thorough molecular classification is complicated and expensive, currently preventing widespread use. We aimed to reproduce the results of molecular classification using only simple techniques, that is, immunohistochemical analysis and in situ hybridization. We classified a cohort of 349 successive gastric adenocarcinomas into 5 subtypes, on the basis of protein or mRNA expression of MLH1, E-cadherin, p53, and Epstein-Barr virus...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27803929/advances-in-understanding-how-heavy-metal-pollution-triggers-gastric-cancer
#11
REVIEW
Wenzhen Yuan, Ning Yang, Xiangkai Li
With the development of industrialization and urbanization, heavy metals contamination has become a major environmental problem. Numerous investigations have revealed an association between heavy metal exposure and the incidence and mortality of gastric cancer. The mechanisms of heavy metals (lead, cadmium, mercury, chromium, and arsenic) contamination leading to gastric cancer are concluded in this review. There are four main potential mechanisms: (1) Heavy metals disrupt the gastric mucosal barrier by decreasing mucosal thickness, mucus content, and basal acid output, thereby affecting the function of E-cadherin and inducing reactive oxygen species (ROS) damage...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27802436/win-55-212-2-inhibits-the-epithelial-mesenchymal-transition-of-gastric-cancer-cells-via-cox-2-signals
#12
Xiangshu Xian, Liuye Huang, Bo Zhang, Chengrong Wu, Jun Cui, Zhihua Wang
BACKGROUND: Cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to reports that they can affect the tumor growth, migration, and metastasis. Previous studies showed that the cannabinoid agonist WIN 55,212-2 (WIN) was associated with gastric cancer (GC) metastasis, but the mechanisms were unknown. METHODS: The effects of WIN on GC cell migration and invasion were analyzed by the wound-healing assay and Transwell assay...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27781410/expression-profile-of-e-cadherin-estrogen-receptors-and-p53-in-early-onset-gastric-cancers
#13
Fan Zhou, Yuanyuan Xu, Jiong Shi, Xing Lan, Xiaoping Zou, Lei Wang, Qin Huang
Early-onset gastric cancer (EOGC) is predominant in females, diffuse histology, and hereditary pattern. Germline mutation of CDH1 and p53 has been reported previously and female dominance was speculated to be associated with estrogen and its receptors. Expression of E-cadherin, estrogen receptor α (ERα), estrogen receptor β (ERβ), and p53 in EOGC remains unclear, which was the focus of this study, to assess clinical significance of their expression in EOGC. The expression of E-cadherin, ERα, ERβ, and p53 in tumors and normal tissues from surgically resected EOGCs was assessed by immunohistochemistry (n = 139) and Western blot (n = 7) methods, respectively...
October 25, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27779657/adam17-promotes-epithelial-mesenchymal-transition-via-tgf-%C3%AE-smad-pathway-in-gastric-carcinoma-cells
#14
Min Xu, Hailang Zhou, Chunli Zhang, Junbo He, Hong Wei, Meng Zhou, Ying Lu, Yaocheng Sun, Jerry Wanming Ding, Jian Zeng, Wanxin Peng, Fengyi Du, Aihua Gong
Although a disintegrin and metalloproteinase-17 (ADAM17) overexpression has been demonstrated in numerous human tumors including gastric cancer, its role in gastric cancer development remains to be clarified. In the present study, we identify that ADAM17 activates TGF-β/Smad signaling to promote epithelial-mesenchymal transition (EMT) in gastric cancer cells. We found that ADAM17 promotes proliferation, migration and invasion in gastric carcinoma cells. Subsequently, we revealed that silencing ADAM17 induces the expression of epithelial marker of E-cadherin and downregulates expression of mesenchymal markers including N-cadherin, vimentin and Snail in MGC803 and MKN45 cells, whereas ADAM17 overexpression reverses these changes in BGC823 and HGC27 cells...
October 21, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27767089/the-effect-of-oxamflatin-on-the-e-cadherin-expression-in-gastric-cancer-cell-line
#15
E Faghihloo, Y Araei, M Mohammadi, H Mirzaei, H R Mohammadi, T Mokhtari-Azad
Gastric cancer is among the leading causes of cancer-related death, and the symptoms are commonly characterized in advanced stages. Histone acetylation is among the most important epigenetic alterations occurring during cancer development. In addition, reduced E-cadherin expression is a major contributor in the process of tumor cell invasion and metastasis. Oxamflatin is a histone deacetylase inhibitor that has been suggested as a promising anti-tumor agent; yet its effect on the viability and invasion of gastric tumor cells is unclear...
November 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27733664/diffuse-gastric-carcinoma-undergoes-characteristic-phenotypic-changes-in-the-intravascular-environment-evidence-for-a-reversal-of-the-epithelial-mesenchymal-transition-in-lymphovascular-metastasis
#16
Tim S Bracey, Louise C Keers, Susan A Adams, Mark E F Smith
This article reports differences between the properties of extravascular carcinoma, which generally forms the vast bulk of a tumor, and those of intravascular carcinoma, at both primary and metastatic lymph node sites. In a morphological and immunohistochemical study of 19 diffuse gastric adenocarcinomas, we report that in comparison to extravascular carcinoma, the intravascular tumor compartment showed frequent and profound phenotypic change, including increased tumor cell cohesion, differentiation and cadherin/catenin expression...
October 12, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27729612/deletion-of-iqgap1-promotes-helicobacter-pylori-induced-gastric-dysplasia-in-mice-and-acquisition-of-cancer-stem-cell-properties-in-vitro
#17
Emilie Bessède, Silvia Molina, Luis Acuña Amador, Pierre Dubus, Cathy Staedel, Lucie Chambonnier, Alice Buissonnière, Elodie Sifré, Alban Giese, Lucie Bénéjat, Benoît Rousseau, Pierre Costet, David B Sacks, Francis Mégraud, Christine Varon
Helicobacter pylori infection is responsible for gastric carcinogenesis but host factors are also implicated. IQGAP1, a scaffolding protein of the adherens junctions interacting with E-cadherin, regulates cellular plasticity and proliferation. In mice, IQGAP1 deficiency leads to gastric hyperplasia. The aim of this study was to elucidate the consequences of IQGAP1 deletion on H. pylori-induced gastric carcinogenesis.Transgenic mice deleted for iqgap1 and WT littermates were infected with Helicobacter sp., and histopathological analyses of the gastric mucosa were performed...
October 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27706737/association-between-the-cdh1-472dela-and-160c-a-polymorphisms-and-diffuse-and-intestinal-gastric-cancer-in-a-mexican-population
#18
A R Bustos-Carpinteyro, N Delgado-Figueroa, E Santiago-Luna, M T Magaña-Torres, J Y Sánchez-López
Gastric cancer (GC), the third leading cause of cancer-related deaths in Mexico and worldwide, can be classified into diffuse (DGC) or intestinal (IGC) types based on its histological characteristics. DGC is characterized by reduced expression of the cell adhesion protein E-cadherin, which is encoded by CDH1. The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results...
September 16, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27706642/snail-induced-epithelial-mesenchymal-transition-in-gastric-carcinoma-cells-and-generation-of-cancer-stem-cell-characteristics
#19
Y J Yang, Z B Li, G R Zhang, L J Wu, J Y Yu, L J Hu, Y L Zhou, H D Wang, D Liang
Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer stem cell characteristics of Snail-overexpressed cells. A pEGFP-C1-Snail eukaryotic expression plasmid was constructed and pEGFP-C1(-) and pEGFP-C1-Snail plasmids were extracted and transfected into SGC7901 cells using Lipofectamine 2000...
August 29, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27698811/expression-of-foxm1-and-the-emt-associated-protein-e-cadherin-in-gastric-cancer-and-its-clinical-significance
#20
Jing Zhang, Xiao-Yu Chen, Ke-Jian Huang, Wei-Dong Wu, Tao Jiang, Jun Cao, Li-Sheng Zhou, Zheng-Jun Qiu, Chen Huang
The aim of the present study was to investigate the expression of forkhead box M1 (FoxM1) and E-cadherin in tissues of gastric cancer in order to reveal any correlation between FoxM1, E-cadherin and clinicopathological parameters. The association between FoxM1 and E-cadherin in the development and progression of gastric cancer was also investigated. The expression of FoxM1 and E-cadherin in gastric cancer and adjacent normal tissue on tissue microarray was detected using immunohistochemistry. The clinicopathological significance of FoxM1 and E-cadherin in gastric cancer was explored, and the association between FoxM1 and E-cadherin was further examined using statistical techniques...
October 2016: Oncology Letters
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