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e_cadherin expression of gastric cancer

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https://www.readbyqxmd.com/read/28209205/long-noncoding-agap2-as1-is-activated-by-sp1-and-promotes-cell-proliferation-and-invasion-in-gastric-cancer
#1
Fuzhen Qi, Xianghua Liu, Hao Wu, Xiang Yu, Chenchen Wei, Xiaodan Huang, Guozhong Ji, Fengqi Nie, Keming Wang
BACKGROUND: Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and cancer progression. Recently, the lncRNA AGAP2-AS1 was identified as an oncogenic lncRNA in human non-small cell lung cancer (NSCLC) and its elevated expression was linked to NSCLC development and progression. However, the expression pattern and molecular mechanism of AGAP2-AS1 in gastric cancer (GC) have not been characterized. METHODS: Bioinformatic analysis was performed to determine AGAP2-AS1 expression levels in the GC and normal tissues using gene profiling data from the Gene Expression Omnibus...
February 16, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28132880/pseudolaric-acid-b-inhibits-gastric-cancer-cell-metastasis-in-vitro-and-in-haematogenous-dissemination-model-through-pi3k-akt-erk1-2-and-mitochondria-mediated-apoptosis-pathways
#2
Dan Wang, Yan Xin, Yanqiu Tian, Wenhui Li, Dan Sun, Yi Yang
Pseudolaric acid B (PAB) is the major bioactive constituent in the root bark of Pseudolarix kaempferi and has been reported to have cytotoxicity against tumor cells. Our in vivo experiments showed that PAB could inhibit gastric cancer cell lung metastasis in a nude mouse haematogenous dissemination model. To evaluate the anti-metastasis mechanism of PAB in gastric cancer cells, cytological experiments were performed. The results showed that PAB could inhibit the adhesion ability to matrigel, migration, invasion and colony formation ability of BGC-823 and MKN-45 cells...
January 26, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28130110/tnf-%C3%AE-inducing-protein-of-helicobacter-pylori-induces-epithelial-mesenchymal-transition-emt-in-gastric-cancer-cells-through-activation-of-il-6-stat3-signaling-pathway
#3
Guodong Chen, Na Tang, Chao Wang, Linqiao Xiao, Minjun Yu, Lanhua Zhao, Hengling Cai, Liang Han, Chengyuan Xie, Yan Zhang
Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). Although it has been proved that Tipα is a strong inducer of epithelial-mesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Current evidence indicates that the oncogenic transcription factor signal transducers and activators of transcription 3 (STAT3) is inappropriately activated in multiple malignancies, including gastric cancer...
January 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28128310/droplet-based-microtumor-model-to-assess-cell-ecm-interactions-and-drug-resistance-of-gastric-cancer-cells
#4
Minjeong Jang, Ilkyoo Koh, Seok Jae Lee, Jae-Ho Cheong, Pilnam Kim
Gastric cancer (GC) is a common aggressive malignant tumor with high incidence and mortality worldwide. GC is classified into intestinal and diffuse types according to the histo-morphological features. Because of distinctly different clinico-pathological features, new cancer therapy strategies and in vitro preclinical models for the two pathological variants of GC is necessary. Since extracellular matrix (ECM) influence the biological behavior of tumor cells, we hypothesized that GC might be more similarly modeled in 3D with matrix rather than in 2D...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096693/gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of-the-literature-and-possible-underlying-mechanisms
#5
J Carlos Villa Guzmán, J Espinosa, R Cervera, M Delgado, R Patón, J M Cordero García
Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28091828/liver-x-receptor-%C3%AE-lxr%C3%AE-promoted-invasion-and-emt-of-gastric-cancer-cells-by-regulation-of-nf-%C3%AE%C2%BAb-activity
#6
Linhua Ji, Bin Zhang, Gang Zhao
Aberrant expression of Liver X receptor α (LXRα) has been frequently reported in various types of cancers excluding gastric cancer (GC). Moreover, the role of LXRα in human GC has not been previously reported. In this study, we investigated the effect of LXRα down-regulation on invasion and EMT of GC. The expression of LXRα in GC cell lines was detected by real-time PCR. The LXRα siRNA was transiently transfected into GC cells using Lipofectamine™ 2000 reagent. Subsequently, cell invasive ability was evaluated by Transwell assays...
January 16, 2017: Human Cell
https://www.readbyqxmd.com/read/28081541/circular-rna-0000096-affects-cell-growth-and-migration-in-gastric-cancer
#7
Peifei Li, Huilin Chen, Shengcan Chen, Xiaoyan Mo, Tianwen Li, Bingxiu Xiao, Rui Yu, Junming Guo
BACKGROUND: Circular RNAs (circRNAs) are a class of non-coding RNAs broadly expressed in cells of various species. Their role in cancers, especially in gastric cancer, is poorly understood. METHODS: Circular RNA 0000096 (hsa_circ_0000096) levels in 101 paired gastric cancer tissues and adjacent non-tumorous tissues from patients with gastric cancer were detected by real-time quantitative reverse transcription-polymerase chain reaction. A receiver operating characteristic curve was generated to evaluate the diagnostic value of hsa_circ_0000096...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28077118/malat1-promoted-invasiveness-of-gastric-adenocarcinoma
#8
Na Keum Lee, Jung Hwa Lee, Cristina Ivan, Hui Ling, Xinna Zhang, Chan Hyuk Park, George A Calin, Sang Kil Lee
BACKGROUND: Gastric cancer is the second leading cause of cancer globally, and the mechanism of its pathogenesis is still largely unknown. Recently, non-coding RNAs have been recognized to promote metastasis in various cancers, including gastric cancer. METHODS: We found that metastasis associated lung adenocarcinoma transcript-1 (MALAT1) is upregulated in gastric cancer tissue compared to adjacent normal tissue, as determined by microarray and subsequent qRT-PCR, then investigated the impact of MALAT1 on apoptosis, cell proliferation, and the cell cycle to dissect the carcinogenesis of gastric cancer, and examined mechanisms of invasion and metastasis...
January 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28076840/hif-1%C3%AE-induces-the-epithelial-mesenchymal-transition-in-gastric-cancer-stem-cells-through-the-snail-pathway
#9
Shi-Wei Yang, Zhi-Gang Zhang, Ying-Xue Hao, Yong-Liang Zhao, Feng Qian, Yan Shi, Ping-Ang Li, Chun-Yang Liu, Pei-Wu Yu
Substantial evidence suggests that the epithelial-mesenchymal transition (EMT) phenotype is associated with the invasive characteristics of cancer stem cells (CSCs),which possess an EMT phenotype that may predominate in tumor invasion and metastasis. However, the mechanisms for the generation and regulation of these CSCs have not been clearly defined. As hypoxia and EMT-related factors may have important functions in EMT-like CSCs, the aim of this study was to investigate the effects of hypoxia on these cells...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28076475/expression-of-e-cadherin-and-wnt-pathway-proteins-betacatenin-apc-tcf-4-and-survivin-in-gastric-adenocarcinoma-clinical-and-pathological-implication
#10
Rodrigo Rego Lins, Celina Tizuko Fujiyama Oshima, Levindo Alves de Oliveira, Marcelo Souza Silva, Ana Maria Amaral Antonio Mader, Jaques Waisberg
Background: Gastric cancer is the fifth most frequent cancer and the third most common cause of cancer-related deaths worldwide.It has been reported that Wnt/ betacatenin pathway is activated in 30-50% of these tumors. However,the deregulation of this pathway has not been fully elucidated. Aim: To determine the expression of E-cadherin, betacatenin, APC, TCF-4 and survivin proteins in gastric adenocarcinoma tissues and correlate with clinical and pathological parameters...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28075173/tgf%C3%AE-1-induced-lncrna-uca1-upregulation-promotes-gastric-cancer-invasion-and-migration
#11
Zhong-Kun Zuo, Yi Gong, Xiang-Heng Chen, Fei Ye, Zheng-Ming Yin, Qian-Ni Gong, Jiang-Sheng Huang
According to recent studies, long noncoding RNA urothelial carcinoma associated 1 (UCA1) is involved in the development and progression of many malignant tumors, including gastric cancer (GC). We validated the detailed role of UCA1 in human GC cell lines and GC tissues so as to determine its exact function and the underlying mechanism of GC invasion and migration. In our research, lncRNA-UCA1 was specifically upregulated in GC tissues and cell lines, and augmented GC cell proliferation, and invasive and migratory capabilities...
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28059478/amplified-7q21-22-gene-mcm7-and-its-intronic-mir-25-suppress-col1a2-associated-genes-to-sustain-intestinal-gastric-cancer-features
#12
Tamilzhalagan Sembulingam, Dhanasekaran Rathinam, Kumaresan Ganesan
Frequent amplification of 7q21-22 genomic region is known in gastric cancer. Multiple genes including SHFM1, MCM7, and COL1A2 were reported to be the potential cancer candidate genes of this 20 Mb amplicon. This amplicon has two polycistrionic miRNA clusters and in the present study, miR-106b-25 cluster located in intron-13 of MCM7 was identified to express in gastric tumors. Among the 7q21-22 candidate genes, SHFM1 and MCM7 are expressed in intestinal type gastric tumors, whereas COL1A2 is expressed in diffuse type gastric tumors...
January 6, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28009991/low-expression-of-rap1gap-is-associated-with-epithelial-mesenchymal-transition-emt-and-poor-prognosis-in-gastric-cancer
#13
Ya Yang, Jia Zhang, Yan Yan, Hui Cai, Min Li, Kai Sun, Jizhao Wang, Xu Liu, Jiansheng Wang, Xiaoyi Duan
Rap1GAP is a crucial tumor suppressor, but its role in gastric cancer (GC) is little investigated. In this study, we found that the expression of Rap1GAP was decreased in GC. Low expression of Rap1GAP was positively correlated with advanced pTNM stage, Borrmann types, tumor diameter and poor prognosis in patients with GC. Low expression of Rap1GAP correlated with loss of E-cadherin expression, and anomalous positivity of MMP2 expression. Multivariate analysis showed that low expression of Rap1GAP was an independent prognostic factor...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27928465/gene-expression-and-pathway-analysis-of-ctnnb1-in-cancer-and-stem-cells
#14
Shihori Tanabe, Takeshi Kawabata, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki
AIM: To investigate β-catenin (CTNNB1) signaling in cancer and stem cells, the gene expression and pathway were analyzed using bioinformatics. METHODS: The expression of the catenin β 1 (CTNNB1) gene, which codes for β-catenin, was analyzed in mesenchymal stem cells (MSCs) and gastric cancer (GC) cells. Beta-catenin signaling and the mutation of related proteins were also analyzed using the cBioPortal for Cancer Genomics and HOMology modeling of Complex Structure (HOMCOS) databases...
November 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27917905/establishment-of-a-gastric-cancer-subline-with-high-metastatic-potential-using-a-novel-microfluidic-system
#15
Zhe-Zhou Chen, Wan-Ming Li, Yu Zhang, Min Yu, Lian-Feng Shan, De-Zheng Yuan, Fu-Rong Liu, Jin Fang
Metastasis is an important hallmark of malignant tumors. In this study, we developed a microfluidic system to screen highly metastatic sublines via differential resolution of cell invasiveness. The system was composed of a PDMS-glass device connected with a syringe pump and a Petri dish. To facilitate the selection process, a long-term cell invasion driving force based on a chemotactic factor gradient was created using the Petri dish-based liquid supply pattern, and the invasive cells were collected for round-by-round selection via an open region in the chip...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904778/long-non-coding-rna-ccat2-promotes-gastric-cancer-proliferation-and-invasion-by-regulating-the-e-cadherin-and-lats2
#16
Yong-Jun Wang, Jian-Zhen Liu, Pei Lv, Yi Dang, Jiang-Yan Gao, Yong Wang
Dysregulation of long non-coding RNAs (lncRNAs) play important roles in tumor development and progression. The long non-coding RNA CCAT2 has been identified to be up-regulated in gastric cancer (GC). However, the detailed molecular mechanism of CCAT2 involved in GC progression is still unknown. The aim of this study was to explore the expression and role of CCAT2 in GC progression. In the study, the expression levels of CCAT2 were significantly up-regulated in 108 cases GC tissues compared with adjacent non-tumor tissues by qRT-PCR analysis...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27904681/mir-330-3p-inhibits-gastric-cancer-progression-through-targeting-msi1
#17
Aoran Guan, Hui Wang, Xun Li, Hui Xie, Ruotian Wang, Yankun Zhu, Ruhong Li
Increasing evidences demonstrated that microRNAs (miRNAs) play critical roles in the human tumor development and progression. In our study, we found that miR-330-3p expression was downregulated in gastric cancer cell lines and tissues. Ectopic expression of miR-330-3p suppressed the gastric cancer cell proliferation, colony formation and migration. Overexpression of miR-330-3p promoted E-cadherin expression and inhibited the expression of N-cadherin, vimentin and snail. We identified Musashi-1 (MSI1) as a direct target gene of miR-330-3p in gastric cancer cell...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27900025/pbx3-promotes-gastric-cancer-invasion-and-metastasis-by-inducing-epithelial-mesenchymal-transition
#18
Shuanhu Wang, Chenglong Li, Wenbin Wang, Chungen Xing
The overexpression of pre-leukemia transcription factor 3 (PBX3) in tumors plays an important role in invasion, metastasis and proliferation in a variety of human cancer types. Tumor metastasis and angiogenesis significantly contribute to the progression of cancer and create challenges for cancer therapy. In the present study, reverse transcription-polymerase chain reaction demonstrated that PBX3 was upregulated in gastric cancer (GC) tissues and Transwell assay revealed that the overexpression of PBX3 promoted GC invasion and metastasis in vitro...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899979/aspirin-inhibits-the-proliferation-and-migration-of-gastric-cancer-cells-in-p53-knockout-mice
#19
Xue-Fu Li, Bing-Zhong Xu, Shi-Zhen Wang
The aim of the present study was to investigate the effect of aspirin on the cell proliferation and migration of gastric cancer cells in p53-knockout mice. Twenty p53(-/-) male mice aged 6 to 7 weeks, with an average weight of 20±3 g were used. The model of gastric cancer was established by the implantation of a mouse forestomach carcinoma cell line, subcutaneously, at the back of the neck, and then the mice were randomly divided into two groups after establishment of the model (control group, n=10; experimental group, n=10)...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27882939/direct-regulation-of-foxk1-by-c-jun-promotes-proliferation-invasion-and-metastasis-in-gastric-cancer-cells
#20
Ying Peng, Pei Zhang, Xiaoting Huang, Qingqing Yan, Meiyan Wu, Ruyi Xie, Yao Wu, Mengnan Zhang, Qingzhen Nan, Jinjun Zhao, Aimin Li, Jing Xiong, Yuexin Ren, Yang Bai, Ye Chen, Side Liu, Jide Wang
Forkhead box (FOX) K1 is a member of the FOX transcription factor superfamily. High FOXK1 expression is associated with several cancers. However, whether FOXK1 expression contributes to gastric cancer (GC) development and progression remains unknown. We analyzed the FOXK1 promoter using the Promo software and found several binding sequence transcription factors, including c-jun. However, the molecular mechanism by which FOXK1 affects the c-jun-mediated malignant phenotype is poorly understood. Here, we found that FOXK1 protein expression was higher in 8/10 (80...
November 24, 2016: Cell Death & Disease
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