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e_cadherin expression of gastric cancer

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https://www.readbyqxmd.com/read/28927050/expression-of-tspan-1-gene-in-patients-with-advanced-gastric-cancer
#1
Yaowu Cai, Maosong Zheng, Zhiqiang Zhao, Hanxing Huang, Wenda Fu, Xuefeng Xu
The present study investigated the correlations of the Tspan-1 gene expression with the clinical characteristics and survival prognoses of patients with advanced gastric cancer. A total of 150 patients with advanced gastric cancer were enrolled in the present study, of whom 84 were at stage II and 66 were at stage III according to the tumor node metastasis (TNM) staging; the immunohistochemical staining method and the semi-quantitative PCR method were used to detect the positive expression rates and mRNA relative expression levels of Tspan-1, vascular endothelial growth factor (VEGF), E-cadherin and N-cadherin...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28906366/risk-factors-for-lymph-node-metastasis-of-early-gastric-cancers-in-patients-younger-than-40
#2
Tao Ji, Fan Zhou, John Wang, Li Zi
This research aims to explore the potential risk factors of lymph node metastasis (LNM) for early gastric cancers in young patients.We retrospectively collected data from 4287 patients who underwent gastrectomy from January 2005 to December 2015 at Linyi People's Hospital. Of these, we enrolled 397 eligible consecutive patients who had early gastric cancer, then divided them into 2 groups according to age (≤40 years and >40 years). The association between the clinicopathological factors and LNM was analyzed by univariate and multivariate analysis...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28895255/ubr2-enriched-in-p53-mbmmsc-exosome-promoted-gastric-cancer-progression-via-wnt-%C3%AE-catenin-pathway
#3
Jiahui Mao, Zhaofeng Liang, Bin Zhang, Huan Yang, Xia Li, Hailong Fu, Xu Zhang, Yongmin Yan, Wenrong Xu, Hui Qian
The deficiency or mutation of p53 has been known to be linked to several types of cancers. Mesenchymal stem cell (MSC) is an important component in tumor microenvironment and exosomes secreted by MSCs can transfer bioactive molecules including proteins and nucleic acid to another cells in tumor microenvironment to influence the progress of tumor. However, whether the state of p53 in MSCs can impact the bioactive molecule secretion of exosomes to promote cancer progression and the regulatory mechanism remain elusive...
September 12, 2017: Stem Cells
https://www.readbyqxmd.com/read/28893318/icg-001-suppresses-growth-of-gastric-cancer-cells-and-reduces-chemoresistance-of-cancer-stem-cell-like-population
#4
Yi Liu, Hui Chen, Peiming Zheng, Yingxia Zheng, Qin Luo, Guohua Xie, Yanhui Ma, Lisong Shen
BACKGROUND: ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with β-catenin and inhibits CBP function as a co-activator of Wnt/β-catenin-mediated transcription. Given its ability to inhibit Wnt/β-catenin signaling pathway, ICG-001 has been used in some tumor types to exert its anticarcinogenic effect. Here, we examined ICG-001 and its potential role as a therapeutic in gastric cancer (GC). METHODS: The gastric cancer cell lines SGC-7901, MGC-803, BGC-823 and MKN-45 were used in vitro and in vivo...
September 11, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28875011/evaluation-of-e-cadherin-expression-in-gastric-cancer-and-its-correlation-with-clinicopathologic-parameters
#5
Zhila Torabizadeh, Anahita Nosrati, Seyedeh Neda Sajadi Saravi, Jamshid Yazdani Charati, Ghasem Janbabai
Background: Gastric cancer is one of the most common cancers in the world. There are many genomic and molecular factors that cause gastric cancer to occur. Also, many markers that associate with tumor invasiveness have been known. E-cadherin is a calcium- mediated cell adhesion molecule. In some studies, abnormal expression of E-cadherin has been seen in gastric carcinoma. However, in the studies done there has been some conflicting information about abnormal expression of this marker in a variety of gastric carcinoma and also about the expression of this marker and its correlation with various clinicopathologic factors of tumor...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28871949/-knock-down-of-zeb1-inhibits-the-proliferation-invasion-and-migration-of-gastric-cancer-cells
#6
Dengyu Chen, Yifan Chu, Qingwei Zheng, Zhiben Xu, Ping Zhou, Sheng Li
Objective To down-regulate the expression of zinc-finger E-box binding homeobox 1 (ZEB1) gene by shRNA, and investigate its effect on invasion, migration and proliferation, as well as the related gene expressions of lncRNA HOTAIR and E-cadherin in human gastric cancer BGC823 cells. Methods RNA interfering (RNAi) was used to knock down ZEB1 in gastric cancer BGC823 cells. The recombinant plasmid shZEB1 was constructed and transfected into the gastric cancer BGC823 cells by Lipofectamine(TM) 2000, and the stably transfected cells were isolated by G418 selection and limited dilution...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28832634/expression-and-potential-roles-of-sodium-potassium-atpase-and-e-cadherin-in-human-gastric-adenocarcinoma
#7
Shih-Ho Wang, Kuan-Lin Wang, Wen-Kai Yang, Tsung-Han Lee, Wan-Yu Lo, Jane-Dar Lee
BACKGROUND: Gastric adenocarcinoma originates from an abnormal epithelium. The aim of this study was to investigate the expression of sodium-potassium ATPase (NKA), a transmembrane protein located in the epithelium for Na+ and K+ transportation, and E-cadherin, which are both crucial for the epithelium and adherens junction, as potential gastric cancer biomarkers. METHODS: 45 patients diagnosed with gastric adenocarcinoma were recruited. Immunohistochemistry and immunofluorescence were conducted to for localization of NKA α1-, β1-isoform, and E-cadherin...
2017: PloS One
https://www.readbyqxmd.com/read/28819379/hypoxia-inducible-factor-1-alpha-correlates-with-tumor-associated-macrophages-infiltration-influences-survival-of-gastric-cancer-patients
#8
Wei-Jie Zhang, Cheng Chen, Zhi-Hua Zhou, Shan-Ting Gao, Teong Jin Tee, Liu-Qing Yang, Yuan-Yuan Xu, Tao-Hong Pang, Xin-Yun Xu, Qi Sun, Min Feng, Hao Wang, Chun-Lei Lu, Guo-Zhong Wu, Sheng Wu, Wen-Xian Guan, Gui-Fang Xu
Background: Hypoxia was a common feature for accelerating tumor metastasis by both inducting epithelial-mesenchymal transition (EMT) of tumor cells and polarization of tumor-associated macrophages (TAMs). The association and roles between hypoxia, EMT and TAMs in the biological behavior of gastric cancer (GC) for the time being recurrence is unclear. Material and methods: hypoixa by expression of hypoxia-inducible factor-1 alpha (HIF-1α), polarized functional status of infiltrated TAMs by immunohistochemical staining of CD68 and CD163, and the expression of E-cadherin as EMT property had been evaluated in 236 patients consecutive with histologically confirmed GC...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28761361/circ-104916-is-downregulated-in-gastric-cancer-and-suppresses-migration-and-invasion-of-gastric-cancer-cells
#9
Jin Li, Li Zhen, Yan Zhang, Liying Zhao, Hao Liu, Danxian Cai, Hao Chen, Jiang Yu, Xiaolong Qi, Guoxin Li
Circular RNAs are a large class of noncoding RNA that have shown huge capabilities as gene regulators. Recent evidence suggest that circular RNAs are associated with many diseases, especially cancer. However, little attention has been focused on the expression and function of circular RNA in gastric cancer (GC). In this study, we demonstrate that the expression of circ-104916 is downregulated in GC tissues and cell lines. A lower expression of circ-104916 appeared in deeper invasion depth, higher tumor stage and more frequent lymphatic metastasis patients...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28760854/oncogenic-kras-and-p53-loss-drive-gastric-tumorigenesis-in-mice-that-can-be-attenuated-by-e-cadherin-expression
#10
Jacob Till, Changhwan Yoon, Bang-Jin Kim, Kerry C Roby, Prince Addai, Evan Jonokuchi, Laura H Tang, Sam S Yoon, Sandra Ryeom
Gastric adenocarcinoma (GA) is the third leading cause of cancer-related death worldwide, but no models exist to readily investigate distant metastases which are mainly responsible for mortality in this disease. Here we report the development of a genetically engineered mouse model of GA tumorigenesis based on Kras(G12D) expression plus inactivation of E-cadherin (Cdh1) and p53 in the gastric parietal cell lineage. Intestinal and diffuse gastric tumors arise rapidly in this model, which displays a median survival of 76 days...
July 31, 2017: Cancer Research
https://www.readbyqxmd.com/read/28754864/foxm1-facilitates-gastric-cancer-cell-migration-and-invasion-by-inducing-cathepsin-d
#11
Li Yang, Ming Cui, Liang Zhang, Lei Song
Forkhead box M1 (FOXM1) has been reported as a vital transcription factor in different human malignancies. To date, the mechanisms of FOXM1 in modulating the invasion and metastasis of gastric cancer cells have not been elucidated. In the present study, we found that overexpression of FOXM1 prompted cell migration and invasion of gastric cancer, and increased the expression of Cathepsin D (Cath-D). However, FOXM1 siRNA repressed cell migration and invasion, and also decreased the expression of Cath-D in gastric cancer cells...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28744137/polypeptide-n-acetylgalactosaminyltransferase-6-expression-in-gastric-cancer
#12
Yan Guo, Jingjing Shi, Jun Zhang, Haixin Li, Ben Liu, Hua Guo
Gastric cancer (GC) is one of the leading causes of cancer-related deaths, with limited improvement in its clinical outcome worldwide. Aberrant mucin-type O-glycosylation is a critical event widespread in the development of GC. Polypeptide N-acetylgalactosaminyltransferases (GALNTs) regulate the initial step and determine the sites of mucin-type O-glycoprotein bio-synthesis. GALNT6 has considerable potential as a biomarker in various cancers. The roles of GALNT6 in GC were analyzed, and the results showed that GALNT6 expression markedly increased in GC tissues compared with those in adjacent gastric tissues...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28726786/calcium-binding-protein-s100a14-induces-differentiation-and-suppresses-metastasis-in-gastric-cancer
#13
Min Zhu, Hongyi Wang, Jiantao Cui, Wenmei Li, Guo An, Yuanming Pan, Qingying Zhang, Rui Xing, Youyong Lu
S100A14 is a calcium-binding protein involved in cell proliferation and differentiation as well as the metastasis of human tumors. In this study, we characterized the regulation of S100A14 expression between biological signatures and clinical pathological features in gastric cancer (GC). Our data demonstrated that S100A14 induced the differentiation of GC by upregulating the expression of E-cadherin and PGII. Moreover, S100A14 expression negatively correlated with cell migration and invasion in in vitro and in vivo experimental models...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28718375/emp3-is-induced-by-twist1-2-and-regulates-epithelial-to-mesenchymal-transition-of-gastric-cancer-cells
#14
Ming Han, Wanpeng Xu
In this study, we aimed to explore new downstream effectors of TWIST1/2 in inducing epithelial-to-mesenchymal transition in gastric cancer. Bioinformatic data mining was performed using data in The Cancer Genome Atlas Stomach Adenocarcinoma. Survival curves were generated using Kaplan-Meier plotter. Gastric cancer cell lines (AGS and SGC-7901) were used as in vitro cell model to investigate the regulative effect of TWIST1/2 on epithelial membrane protein 3 expression and the progression of epithelial-to-mesenchymal transition...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28669168/the-160-c-a-cdh1-gene-promoter-polymorphism-and-its-relationship-with-survival-of-patients-with-gastric-cancer-in-kurdistan
#15
Mohammad Nazir Menbari, Sherko Nasseri, Neda Menbari, Ramin Mehdiabadi, Yousef Alipur, Daem Roshani
HASH(0x48841c8) Introduction: Gastric cancer (GC) is the fourth most common type of neoplasm and the second cause of malignancy-related death across much of the world. Complex multi-factorial processes are involved in its genesis, classified in two determinant clusters: non-genetic and genetic . Variation in CDH1 gene expression may play an important role in increasing risk of diffuse and intestinal subtypes of GC. This tumor suppressor gene, located on chromosome 16q22.1, encodes a trans membrane glycoprotein called epithelial cadherin (E-cadherin)...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28656304/mir-138-inhibits-gastric-cancer-growth-by-suppressing-sox4
#16
Lei Pang, Bai Li, Baisong Zheng, Liang Niu, Liang Ge
MicroRNA-138 (miR-138) has been reported to be downregulated and function as a tumor suppressor in several cancers. However, the role and molecular mechanisms of miR-138 in the progression of gastric cancer (GC) remain to be clarified. The aim of the present study was to determine the role of miR-138 in GC progression. In the present study we found that miR-138 expression was downregulated in GC tissues and cell lines. Statistical analysis demonstrated that low expression levels of miR-138 were associated with advanced tumor-node-metastasis (TNM) stage, and lymph node metastasis...
June 22, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28654632/p53-and-protein-phosphorylation-regulate-the-oncogenic-role-of-epithelial-cell-transforming-2-ect2
#17
Yan Chen, Ping Tian, Yi Liu
BACKGROUND Gastric cancer (GC) is the second leading cause of cancer-related death worldwide, but little progress has been achieved in the treatment of advanced or metastatic GC. GC is highly heterogeneous and more studies are needed to elucidate the metastatic mechanisms. Epithelial cell transforming 2 (ECT2) has been reported to be up-regulated in GC tissues, but its signaling mechanisms remain unclear. MATERIAL AND METHODS In this study, we used Western blot analysis to compare the expression level of ECT2 in 2 GC cell lines: MKN1 and MKN45...
June 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28611525/clinical-significance-of-expression-of-proliferating-cell-nuclear-antigen-and-e-cadherin-in-gastric-carcinoma
#18
Lin Hu, Hong-Lang Li, Wei-Feng Li, Jun-Min Chen, Jian-Tao Yang, Jun-Jing Gu, Lin Xin
AIM: to investigate the expression of proliferating cell nuclear antigen (PCNA) and E-cadherin in gastric carcinoma and to analyze their clinical significance. METHODS: A total of 146 patients were selected for this study, including 38 patients with intestinal metaplasia, 42 with dysplasia, and 66 with primary gastric cancer. In addition, 40 patients with normal gastric tissues were selected as controls. The expression of PCNA and E-cadherin was detected by immunohistochemistry...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28601080/microrna-630-suppresses-epithelial-to-mesenchymal-transition-by-regulating-foxm1-in-gastric-cancer-cells
#19
Jing Feng, Xiaojuan Wang, Weihua Zhu, Si Chen, Changwei Feng
In the present study, we investigated the functional role of microRNA (miR)-630 in epithelial-to-mesenchymal transition (EMT) of gastric cancer (GC) cells, as well as the regulatory mechanism. Cells of human GC cell line SGC 7901 were transfected with miR-630 mimic or miR-630 inhibitor. The transfection efficiency was confirmed by qRT-PCR. Cell migration and invasion were determined by Transwell assay. Protein expression of E-cadherin, vimentin, and Forkhead box protein M1 (FoxM1) was tested by Western blot...
June 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28600569/fpr2-promotes-invasion-and-metastasis-of-gastric-cancer-cells-and-predicts-the-prognosis-of-patients
#20
Xi-Lu Hou, Cheng-Dong Ji, Jun Tang, Yan-Xia Wang, Dong-Fang Xiang, Hai-Qing Li, Wei-Wei Liu, Jiao-Xue Wang, He-Zhong Yan, Yan Wang, Peng Zhang, You-Hong Cui, Ji-Ming Wang, Xiu-Wu Bian, Wei Liu
Formyl peptide receptor 2 (FPR2), a classical chemoattractant receptor of G-protein-coupled receptors, is reported to be involved in invasion and metastasis of some cancers, but the role of FPR2 in gastric cancer (GC) has not yet been elucidated. In this study, we found that the levels of FPR2 expression in GC were positively correlated with invasion depth, lymph node metastasis and negatively correlated with the patients' overall survival. Multivariate analysis indicated that FPR2 expression was an independent prognostic marker for GC patients...
June 9, 2017: Scientific Reports
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