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https://www.readbyqxmd.com/read/28811697/role-of-iron-and-copper-in-the-pathogenesis-of-parkinson-s-disease
#1
Mohit Kumar Gangania, Jyoti Batra, Suman Kushwaha, Rachna Agarwal
Parkinson's disease (PD) is an old age disorder of basal ganglia which involves oligomerization of α-synuclein protein and formation of intercellular inclusions known as "Lewy bodies" in substantia nigra and caudate nuclei in brain which is progressive in nature. It is second most prevalent neurodegenerative disorder characterized by tremor at rest, muscle rigidity, slowness of movement (bradykinesia, akinesia), and changes in posture (instability). Both excess and deficiency in levels of transition metals (especially iron, copper) can be detrimental to the central nervous system...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28767021/the-limits-of-stability-in-patients-with-unilateral-vestibulopathy
#2
Rafael Alvarez-Otero, Nicolas Perez-Fernandez
OBJECTIVE: To characterize the stability limits and region in patients with unilateral vestibulopathy according to the side of the lesion and determine if that imposes any bias. To analyze if the stability limits and region depend on the functional deficit as evaluated in the sensory organization test. METHODS: Forty patients with chronic dizziness and without any vertigo spell for least 6 months prior to testing. In all of them, a unilateral vestibulopathy was diagnosed clinically and at vestibular testing...
October 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28758070/prediction-of-post-stroke-falls-by-quantitative-assessment-of-balance
#3
Hyun Haeng Lee, Se Hee Jung
OBJECTIVE: To evaluate characteristics of the postural instability in patients with stroke and to present a prediction model of post-stroke falls. METHODS: Patients with a first-ever stroke who had been evaluated by the Balance Master (BM) at post-stroke 3 months (±1 month) between August 2011 and December 2015 were enrolled. Parameters for the postural instability, such as the weight bearing asymmetry (WBA) and postural sway velocity (PSV), were obtained. The fall events in daily lives were assessed via structured telephone interview with a fall related questionnaire...
June 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28743580/comparison-of-balance-strategies-in-mountain-climbers-during-real-altitude-exposure-between-1-500m-and-3-200m-effects-of-age-and-expertise
#4
Anne-Violette Bruyneel, Arnaud Humbert, Marc Bertrand
PURPOSE: The aim of this study was to estimate the effect of altitude (1500m vs. 3200m) on balance strategies, and to determine the influence of age (> or <40 years) and expertise (> or <20days of mountain climbing/year) on postural stability at altitude. METHOD: Eighty-nine volunteer mountaineers were tested at 1500m, 3200m immediately after exiting the cable car and at 3200m following the climb and return. Double-leg stance with eyes closed and single-leg stance with eyes open were tested...
July 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28716427/influence-of-l-dopa-on-subtle-motor-signs-in-heterozygous-parkin-and-pink1-mutation-carriers
#5
Anne Weissbach, Inke R König, Katja Hückelheim, Peter P Pramstaller, Elisa Werner, Norbert Brüggemann, Vera Tadic, Katja Lohmann, Tobias Bäumer, Alexander Münchau, Meike Kasten, Christine Klein
INTRODUCTION: A latent nigrostriatal deficit and its possible clinical consequences in asymptomatic heterozygous Parkin and PINK1 mutation carriers (AMC) have been a matter of investigation in recent years. Notably, mild Parkinsonian signs in heterozygous mutation carriers can be so subtle that they may be missed if not specifically investigated. METHODS: We studied 15 heterozygous Parkin and PINK1 AMC and 18 age- and sex-matched mutation-negative controls using a standardized video, instructing the probands to perform relevant parts of the UPDRS III to investigate fine motor movements at baseline and after first-time L-Dopa administration...
July 8, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28713084/evalution-of-the-effectiveness-of-multimodal-approach-to-the-management-of-cervical-vertigo
#6
Olexandr A Jaroshevskyi, Oleksandr S Payenok, Anna V Logvinenko
INTRODUCTION: Vertigo is one of the most common complaints among patients consulting neurologists and general practitioners - family medicine. A special form of dizziness is cervical vertigo. However, the presence of chronic vertigo and imbalance in this group of patients makes it possible to include the treatment of vestibular rehabilitation in the program. AIM: Evalution of the effectiveness of multimodal approach to the management of cervical vertigo. MATERIAL AND METHODS: 109 patients aged from 18 to 45 with vertigo together with myofascial pain syndrome of neck and shoulder area were examined...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28712000/predictors-of-weight-loss-in-early-treated-parkinson-s-disease-from-the-net-pd-ls-1-cohort
#7
Anne-Marie Wills, Ruosha Li, Adriana Pérez, Xuehan Ren, James Boyd
Weight loss is a common symptom of Parkinson's disease and is associated with impaired quality of life. Predictors of weight loss have not been studied in large clinical cohorts. We previously observed an association between change in body mass index and change in Unified Parkinson's Disease Rating Scale (UPDRS) motor and total scores. In this study, we performed a secondary analysis of longitudinal data (1-6 years) from 1619 participants in the NINDS Exploratory Trials in PD Long-term Study-1 (NET-PD LS1) to explore predictors of weight loss in a large prospective clinical trial cohort of early treated Parkinson's disease...
August 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28692855/recuperation-of-slow-walking-in-de-novo-parkinson-s-disease-is-more-closely-associated-with-increased-cadence-rather-than-with-expanded-stride-length
#8
Kyum-Yil Kwon, Hye Mi Lee, Sung Hoon Kang, Seon Jong Pyo, Han Jun Kim, Seong-Beom Koh
INTRODUCTION: Gait characteristics in the early stages of Parkinson's disease (PD) have been less investigated so far. Moreover, the levodopa effect on gait in early PD remains to be further elucidated. We prospectively designed the study to examine gait dynamics and effect of dopaminergic treatment in patients with de novo PD. METHODS: Spatiotemporal parameters were measured in healthy controls and drug naïve patients with PD, using computerized analysis with GAITRite system during usual gait...
July 1, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28684307/discriminant-validity-of-spatial-and-temporal-postural-index-in-children-with-neurodevelopmental-disorders
#9
Maria Pia Bucci, Nathalie Goulème, Coline Stordeur, Eric Acquaviva, Isabelle Scheid, Aline Lefebvre, Christophe-Loïc Gerard, Hugo Peyre, Richard Delorme
Autism, learning disabilities and attention deficit/hyperactive disorder are often comorbid disorders. In order to try and find some markers that might be transnosographic, we hypothesized that abnormal postural sway profiles may discriminate children with neurodevelopmental disorders (NDDs) from typically developing children. The aim of our study was thus to compare spatial and temporal measures of the Center of Pressure in three distinct groups of children with NDDs (high functioning autism spectrum disorders, learning disabilities (dyslexia) and attention deficit/hyperactive disorders) and in typically developing children...
July 3, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28677942/effect-of-fibular-repositioning-taping-in-adult-basketball-players-with-chronic-ankle-instability-a-randomized-placebo-controlled-crossover-trial
#10
Yanina Alves, Fernando Ribeiro, Anabela G Silva
BACKGROUND: Chronic ankle instability presents a high incidence and prevalence in basketbal players. It's important to develop strategies to reduce the functional and mechanical limitations resulting from this condition. To compare the effect of Mulligan ́s fibular repositioning taping with a placebo taping immediatly after application and after a running test (Yo-Yo IRT). METHODS: 16 adult basketball players (10 male, 6 female) with chronic ankle instability and mean age 21...
July 5, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28677937/long-term-outcome-of-surgical-treatment-of-chiari-malformation-without-syringomyelia
#11
Lorenzo Giammattei, Mahmoud Messerer, Roy T Daniel, Nozar Aghakhani, Fabrice Parker
BACKGROUND: Surgical treatment for CM without syringomyelia is still under debate. The aim of this study was to evaluate the long term outcome of surgically treated patients for CM-I without syringomyelia. METHODS: We selected all adult patients who underwent surgery for CM-I without syringomyelia between 1993 and 2010. Only patients with long term follow-up (>5 years) were included. Clinical manifestations, radiologic features, and follow-up data were analyzed...
July 4, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28668186/an-active-balance-board-system-with-real-time-control-of-stiffness-and-time-delay-to-assess-mechanisms-of-postural-stability
#12
Denise R Cruise, James R Chagdes, Joshua J Liddy, Shirley Rietdyk, Jeffrey M Haddad, Howard N Zelaznik, Arvind Raman
Increased time-delay in the neuromuscular system caused by neurological disorders, concussions, or advancing age is an important factor contributing to balance loss (Chagdes et al., 2013, 2016a,b). We present the design and fabrication of an active balance board system that allows for a systematic study of stiffness and time-delay induced instabilities in standing posture. Although current commercial balance boards allow for variable stiffness, they do not allow for manipulation of time-delay. Having two controllable parameters can more accurately determine the cause of balance deficiencies, and allows us to induce instabilities even in healthy populations...
June 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28660004/management-of-recent-elbow-dislocations-functional-treatment-versus-immobilization-a-prospective-study-about-60-cases
#13
Ndeye Fatou Coulibaly, Niane Mouhamadou Moustapha, Hamadi Hadji Djoumoi, Sarr Lamine, Gueye Alioune Badara, Sane André Daniel
OBJECTIVE: To determine our therapeutic posture trough a comparison of functional treatment results versus immobilization in two different periods. INTRODUCTION: For years, the treatment of recent elbow dislocations consisted of reduction and immobilization during 21 days. Given the frequency of stiffness other methods have been tried out. METHOD: A prospective study was carried out from January 2010 to December 2014. Sixty patients averaging 28...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28655059/association-of-autonomic-dysfunction-with-disease-progression-and-survival-in-parkinson-disease
#14
Eduardo De Pablo-Fernandez, Carmen Tur, Tamas Revesz, Andrew J Lees, Janice L Holton, Thomas T Warner
Importance: Evidence suggests that development of autonomic dysfunction (AutD) may negatively affect disease course and survival in patients with synucleinopathies. However, the few available studies on Parkinson disease (PD) have conflicting results, comprise a small number of patients, have short follow-up periods, and lack pathologic confirmation of the diagnosis. Objective: To examine the association of time of onset of AutD with disease progression and survival in PD...
August 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28642694/ehlers-danlos-syndrome-hypermobility-type-impact-of-somatosensory-orthoses-on-postural-control-a-pilot-study
#15
Emma G Dupuy, Pascale Leconte, Elodie Vlamynck, Audrey Sultan, Christophe Chesneau, Pierre Denise, Stéphane Besnard, Boris Bienvenu, Leslie M Decker
Elhers-Danlos syndrome (EDS) is the clinical manifestation of connective tissue disorders, and comprises several clinical forms with no specific symptoms and selective medical examinations which result in a delay in diagnosis of about 10 years. The EDS hypermobility type (hEDS) is characterized by generalized joint hypermobility, variable skin hyperextensibility and impaired proprioception. Since somatosensory processing and multisensory integration are crucial for both perception and action, we put forth the hypothesis that somatosensory deficits in hEDS patients may lead, among other clinical symptoms, to misperception of verticality and postural instability...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28640143/relationship-between-postural-instability-and-subcortical-volume-loss-in-alzheimer-s-disease
#16
Young-Wook Lee, Hyung Lee, In-Sung Chung, Hyon-Ah Yi
The relationship between postural instability and subcortical structure in AD has received less attention. The aims of this study were to assess whether there are differences in the ability to control balance between Alzheimer's disease (AD) and controls, and to investigate the association between subcortical gray matter volumes and postural instability in AD.We enrolled 107 consecutive AD patients and 37 controls. All participants underwent detailed neuropsychological evaluations, T1-weighted MRI at 3 T, and posture assessment using computerized dynamic posturography...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28619181/multifactorial-sleep-disturbance-in-parkinson-s-disease
#17
REVIEW
J Andrew Albers, Pratap Chand, A Michael Anch
Parkinson's disease (PD) is the second most common neurodegenerative disorder, ranking only behind Alzheimer's disease and affecting 2% of the population over the age of 65. Pathophysiologically, PD is characterized by selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta (SNpc) and striatal dopamine depletion. Patients may also exhibit mild-to-severe degeneration of other central and peripheral nervous tissues. The most dramatic symptoms of the disease are profound dopamine-responsive motor disturbances, including bradykinesia, akinesia, rigidity, resting tremor, and postural instability...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28557606/decomposition-of-postural-movements-in-individuals-with-mild-tbi-while-reaching-to-intercept-a-moving-virtual-target
#18
Ksenia I Ustinova
The study analyzed postural and arm movement coordinations in patients with traumatic brain injury (TBI) while standing and reaching for a target moving in a 3D virtual environment. Thirteen individuals with mild TBI and 13 height, sex, and age-matched healthy control individuals were involved. While standing in front of the screen, the participants interacted with the projected environment by reaching for virtual targets. Coordination was analyzed as the percentage of reach-to-intercept cycle time during which their movement toward the target was decomposed with 0% indicating simultaneous motion in three planes or 100% indicating motion in one or two planes only...
July 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28551466/stance-instability-in-preclinical-sca1-mutation-carriers-a-4-year-prospective-posturography-study
#19
Lorenzo Nanetti, Dario Alpini, Valentina Mattei, Anna Castaldo, Alessia Mongelli, Greta Brenna, Cinzia Gellera, Caterina Mariotti
OBJECTIVE: We aimed to study postural balance in preclinical Spinocerebellar ataxia type 1 (SCA1) mutation carriers to identify and observe specific motor functional deficit before evident clinical manifestation. METHODS: Participants were 9 asymptomatic SCA1 mutation carriers (6M/3F), aged 31.8±7years (range 22-44), and 17 age-matched non-carrier controls (5M/12F) (age 18-42). Subjects underwent postural tests on a force platform (Tetrax(®)-IBS, Sunlight Medical Ltd...
May 17, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28527232/three-dimensional-evaluation-of%C3%A2-postural%C3%A2-stability-in-parkinson-s-disease-with-mobile-technology
#20
Sarah J Ozinga, Mandy Miller Koop, Susan M Linder, Andre G Machado, Tanujit Dey, Jay L Alberts
BACKGROUND: Postural instability is a hallmark of Parkinson's disease. Objective metrics to characterize postural stability are necessary for the development of treatment algorithms to aid in the clinical setting. OBJECTIVE: The aim of this project was to validate a mobile device platform and resultant three-dimensional balance metric that characterizes postural stability. METHODS: A mobile Application was developed, in which biomechanical data from inertial sensors within a mobile device were processed to characterize movement of center of mass in the medial-lateral, anterior-posterior and trunk rotation directions...
2017: NeuroRehabilitation
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