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postural instability aging

Cinzia Nasuti, Gloria Brunori, Piera Eusepi, Lisa Marinelli, Roberto Ciccocioppo, Rosita Gabbianelli
INTRODUCTION: Oxidative stress, alpha-synuclein changes, mitochondrial complex I defects and dopamine loss, observed in the striatum of rats exposed to the pesticide permethrin in early life, could represent neuropathological hallmarks of Parkinson's disease (PD). Nevertheless, an animal model of PD should also fulfill criteria of face and predictive validities. This study was designed to: 1) verify dopaminergic status in the striatum and substantia nigra pars compacta; 2) recognize non-motor symptoms; 3) investigate the time-course development of motor disabilities; 4) assess L-Dopa effectiveness on motor symptoms in rats previously exposed to permethrin in early life...
October 15, 2016: Journal of Pharmacological and Toxicological Methods
L Wu, N Mu, F Yang, J Zang, J-P Zheng
OBJECTIVE: The aim of this study is to determine characteristics of non-motor symptoms (NMS) in early Parkinson's disease (PD) with olfactory deficits and to analyze the feasibility of diagnosing PD based on olfactory deficits. PATIENTS AND METHODS: 62 patients without olfactory deficits in early PD (PD group), 58 patients with olfactory deficits in early PD (olfactory deficits group) and 60 healthy examined people (control group) were selected successively. RESULTS: It was found that there was no statistical significance in the difference in ages and courses of disease among the three groups (p > 0...
September 2016: European Review for Medical and Pharmacological Sciences
S V Vasichkin, O S Levin
AIM: To study gait disorders and postural instability in patients with essential tremor (ET). MATERIAL AND METHODS: Forty patients with ET, aged from 29 to 82 years, (mean 64.2±13.0) were examined. Tandem walk, tremor, stability and stabilometry were studied. RESULTS AND CONCLUSION: A half of the patients had gait disorders and postural instability. Though these disorders were mild to moderate, they caused significant subjective discomfort and influenced quality of life...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Jeanne Montastruc, David Amarantini, Valérie Lambert, Evelyne Castel-Lacanal, Philippe Marque, David Gasq
OBJECTIVE: Weight-bearing asymmetry (WBA) at the expense of the paretic side concerns 60% of stroke patients. WBA is associated with poor functional prognosis especially in terms of gait performance [1,2]. The primary objective was to assess the determinants of WBA in stroke patients from clinical and instrumental data. MATERIAL/PATIENTS AND METHODS: The sensitivity (EmNSA), motricity (Fugl-Meyer motor), spatial neglect and visual perception of verticality (VPV) were evaluated in 20 stroke patients (age: 53...
September 2016: Annals of Physical and Rehabilitation Medicine
Salma Jeribi, Abdelmoneem Yahia, Imen Achour, Bouthaina Hammemi, Abdelmoneem Ghorbel, Mohamed Habib Elleuch, Sameh Ghroubi
OBJECTIVE: To determine the effect of completing a vestibular rehabilitation treatment protocol on postural balance, dizziness and quality of life in patients with peripheral vertigo. MATERIAL/PATIENTS AND METHODS: A prospective study concerning patients with instability due to unilateral peripheral vestibular disorder. The patients were evaluated with a clinical examination and a test of static and dynamic balance on the Satel(®) platform in which length, mediolateral (LongX) and anterior-posterior deviations (long Y) were monitored...
September 2016: Annals of Physical and Rehabilitation Medicine
Marie Lumeau, Mathieu Lempereur, Emmanuel Sonnet, Olivier Remy Neris
OBJECTIVE: Distal sensorimotor polyneuropathy (DPN) is a leading risk factor of developing ulcer, including increased pressures at the forefoot. The rocker sole shoes are prescribed to decrease pressures but could induce instability [1]. The aim of this study was to compare the postural stability between normal shoes (NS) and rocker sole shoes (RSS) in patients with type 2 diabetes and DPN. MATERIAL/PATIENTS AND METHODS: In this preliminary, randomized, controlled study, NS and RSS were compared during static standing and gait...
September 2016: Annals of Physical and Rehabilitation Medicine
Nathalie Ribeiro Artigas, Giovana Duarte Eltz, Alexandre Severo do Pinho, Vanessa Bielefeldt Leotti Torman, Arlete Hilbig, Carlos R M Rieder
Background. Changes in proprioception may contribute to postural instability in individuals with neurological disorders. Objectives. Evaluate proprioception in the lower limbs of patients with Parkinson's disease (PD) and the association between proprioception and cognitive ability, motor symptoms, postural instability, and disease severity. Methods. This is a cross-sectional, controlled study that evaluated proprioception in PD patients and healthy age- and sex-matched individuals. Kinetic postural proprioception of the knee was evaluated using an isokinetic dynamometer (Biodex® Multi-Joint System 4 Pro)...
2016: Neuroscience Journal
Sarah J Ozinga, Susan M Linder, Jay L Alberts
OBJECTIVE: To determine the accuracy of inertial measurement unit data from a mobile device using the mobile device relative to posturography to quantify postural stability in individuals with Parkinson's disease (PD). DESIGN: Criterion standard. SETTING: Motor control laboratory at Cleveland Clinic. PARTICIPANTS: Fourteen mild to moderate individuals with PD and 14 healthy age-matched community dwelling controls completed the project...
September 23, 2016: Archives of Physical Medicine and Rehabilitation
Christopher J Burcal, Alejandra Y Trier, Erik A Wikstrom
CONTEXT: Both balance training and selected interventions meant to target sensory structures (STARS) have been shown to be effective at restoring deficits associated with chronic ankle instability (CAI). Clinicians often utilize multiple treatment modalities in patients with CAI. However, evidence for combined intervention effectiveness in CAI patients remains limited. OBJECTIVE: To determine if augmenting a balance training protocol with STARS (BTS) results in greater improvements than balance training (BT) alone in those with CAI...
August 24, 2016: Journal of Sport Rehabilitation
Cameron J Powden, Kathleen K Hogan, Erik A Wikstrom, Matthew C Hoch
CONTEXT: Talocrural joint mobilizations are commonly used to address deficits associated with chronic ankle instability (CAI). OBJECTIVE: Examine the immediate effects of talocrural joint traction in those with CAI. DESIGN: Blinded, crossover. SETTING: Laboratory. PARTICIPANTS: Twenty adults (14 females; age=23.80±4.02years; height=169.55±12.38cm; weight=78.34±16.32kg) with self-reported CAI participated...
August 24, 2016: Journal of Sport Rehabilitation
Kyung-Min Kim, Joseph M Hart, Susan Saliba, Jay Hertel
CONTEXT:  Individuals with chronic ankle instability (CAI) present with decreased modulation of the Hoffmann reflex (H-reflex) from a simple to a more challenging task. The neural alteration is associated with impaired postural control, but the relationship has not been investigated in individuals with CAI. OBJECTIVE:  To determine differences in H-reflex modulation and postural control between individuals with or without CAI and to identify if they are correlated in individuals with CAI...
September 1, 2016: Journal of Athletic Training
Kathleen K Hogan, Cameron J Powden, Matthew C Hoch
BACKGROUND: To investigate the effect of foot posture on postural control and dorsiflexion range of motion in individuals with chronic ankle instability. METHODS: The study employed a cross-sectional, single-blinded design. Twenty-one individuals with self-reported chronic ankle instability (male=5; age=23.76(4.18)years; height=169.27(11.46)cm; weight=73.65(13.37)kg; number of past ankle sprains=4.71(4.10); episode of giving way=17.00(18.20); Cumberland Ankle Instability Score=18...
October 2016: Clinical Biomechanics
Marie Y Davis, Catherine O Johnson, James B Leverenz, Daniel Weintraub, John Q Trojanowski, Alice Chen-Plotkin, Vivianna M Van Deerlin, Joseph F Quinn, Kathryn A Chung, Amie L Peterson-Hiller, Liana S Rosenthal, Ted M Dawson, Marilyn S Albert, Jennifer G Goldman, Glenn T Stebbins, Bryan Bernard, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, David Eidelberg, Paul J Mattis, Martin Niethammer, Dora Yearout, Shu-Ching Hu, Brenna A Cholerton, Megan Smith, Ignacio F Mata, Thomas J Montine, Karen L Edwards, Cyrus P Zabetian
Importance: Parkinson disease (PD) is heterogeneous in symptom manifestation and rate of progression. Identifying factors that influence disease progression could provide mechanistic insight, improve prognostic accuracy, and elucidate novel therapeutic targets. Objective: To determine whether GBA mutations and the E326K polymorphism modify PD symptom progression. Design, Setting, and Participants: The entire GBA coding region was screened for mutations and E326K in 740 patients with PD enrolled at 7 sites from the PD Cognitive Genetics Consortium...
October 1, 2016: JAMA Neurology
Emanuele Spina, Antonio Carotenuto, Maria Gabriella Aceto, Ilaria Cerillo, Francesco Silvestre, Francesco Arace, Paolo Paone, Giuseppe Orefice, Rosa Iodice
BACKGROUND: Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been used in MS only to reduce muscle tone and fatigue alone or together with botulinum toxin. OBJECTIVE: To assess whether FV is effective on walking impairment in a cohort of MS patients...
September 21, 2016: Restorative Neurology and Neuroscience
Vikas Kotagal
Parkinson disease is a chronic progressive syndrome with a broad array of clinical features. Different investigators have suggested the heterogeneous motor manifestations of early Parkinson disease can be conceptualized through a taxonomy of clinical subtypes including tremor-predominant and postural instability and gait difficulty-predominant subtypes. Although it is theoretically valuable to distinguish subtypes of Parkinson disease, the reality is that few patients fit these discrete categories well and many transition from exhibiting elements of one subtype to elements of another...
June 2016: Annals of Clinical and Translational Neurology
Nancy L Low Choy, Mary-Therese M Lucey, Susan L Lewandowski, Benedict J Panizza
OBJECTIVES/HYPOTHESIS: To investigate balance, community mobility, gaze instability, and dizziness handicap and assess falls risk in people who are conservatively managed with small vestibular schwannoma (VS). STUDY DESIGN: Cross-sectional study with controls. METHODS: The study involved 18 people (mean age 58.7 ± 12.2 years) diagnosed with VS (<12 mm) and 22 age-matched controls (mean age 56.9 ± 8.0 years). Measures included standing on firm and foam surfaces with feet apart, then together with eyes open and closed, Timed Up and Go (TUG) test and dual TUG test, Dynamic Gait Index, 6-Minute Walk Test, Halmagyi Impulse Test, Dynamic Visual Acuity Test, and the Dizziness Handicap Inventory...
August 13, 2016: Laryngoscope
Ryan M Peters, Monica D McKeown, Mark G Carpenter, J Timothy Inglis
Age-related changes in the density, morphology, and physiology of plantar cutaneous receptors negatively impact the quality and quantity of balance-relevant information arising from the foot soles. Plantar perceptual sensitivity declines with age and may predict postural instability; however, alteration in lower limb cutaneous reflex strength may also explain greater instability in older adults and has yet to be investigated. We replicated the age-related decline in sensitivity by assessing monofilament and vibrotactile (30 and 250 Hz) detection thresholds near the first metatarsal head bilaterally in healthy young and older adults...
October 1, 2016: Journal of Neurophysiology
Kyunghun Kang, Ji Su Jeon, Taegyeong Kim, Dongho Choi, Pan Woo Ko, Sung Kyoo Hwang, Ho Won Lee
BACKGROUND AND PURPOSE: Our aims were to analyze the characteristics of parkinsonian features and to characterize changes in parkinsonian motor symptoms before and after the cerebrospinal fluid tap test (CSFTT) in idiopathic normal-pressure hydrocephalus (INPH) patients. METHODS: INPH subjects were selected in consecutive order from a prospectively enrolled INPH registry. Fifty-five INPH patients (37 males) having a positive response to the CSFTT constituted the final sample for analysis...
July 26, 2016: Journal of Clinical Neurology
Christopher J Burcal, Erik A Wikstrom
Performing a cognitive task while balancing can result in either increased or decreased sway depending on the nature of the cognitive task, and is commonly used in pathologic populations to evaluate postural performance. A total of 39 participants were recruited into two groups: uninjured controls (n=20, age: 21.9±2.1 years, height: 175.0±11.2cm, mass: 71.3±14.9kg) and chronic ankle instability (n=19, age: 22.1±5.6 years, height: 169.7±7.7cm, mass: 72.9±17.3kg). Participants were asked to perform one of three cognitive tasks while maintaining single limb balance...
July 2016: Gait & Posture
Marcello Moccia, Enrico Tedeschi, Lorenzo Ugga, Roberto Erro, Marina Picillo, Ferdinando Caranci, Paolo Barone, Arturo Brunetti
BACKGROUND: Parkinson's Disease (PD) patients are usually divided into Tremor Dominant (TD) and Postural Instability/Gait Difficulty (PIGD) subtypes. The latter is characterized by axial motor symptoms and worse outcomes, possibly also because of comorbid white matter disease. Therefore, the current study investigated the importance of Age-Related White Matter Changes (ARWMCs) in the development of different PD motor phenotypes. METHODS: The present 4-year longitudinal study recruited 63 de novo PD patients, who underwent MRI at the time of the diagnosis to rate ARWMCs...
August 15, 2016: Journal of the Neurological Sciences
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