keyword
MENU ▼
Read by QxMD icon Read
search

Neck tumor

keyword
https://www.readbyqxmd.com/read/29151106/survival-outcome-of-intermediate-grade-salivary-gland-carcinoma
#1
Gi Cheol Park, Jong-Lyel Roh, Kyung-Ja Cho, Yong Gi Jung, Hyoun Wook Lee, Tae Gyu Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVE: Histological grade is the most important factor for defining treatment strategies and predicting prognosis for salivary gland carcinoma (SGC). We examined factors affecting long-term recurrence and survival among intermediate-grade SGC (IGSGC) patients to define optimal treatment modalities and outcomes. METHODS: We reviewed the clinical and pathological data on 108 IGSGC patients who underwent definitive surgery with or without postoperative radiotherapy...
November 18, 2017: Oncology
https://www.readbyqxmd.com/read/29150876/toxicological-characterization-of-zno-nanoparticles-in-malignant-and-non-malignant-cells
#2
Helena Moratin, Agmal Scherzad, Thomas Gehrke, Pascal Ickrath, Katrin Radeloff, Norbert Kleinsasser, Stephan Hackenberg
The increasing usage of zinc oxide nanoparticles (ZnO-NPs) in industrial applications as well as in consumer products raises concern regarding their potential adverse effects to a greater extend. Numerous studies have demonstrated toxic properties of NPs, however there is still a lack of knowledge concerning the underlying mechanisms. This study was designed to systematically investigate cytotoxicity, apoptosis, cell cycle alterations, and genotoxicity induced by ZnO-NP. Moreover, it was an aim of the investigations to specify the diverse effects of nanoparticle exposure in malignant in comparison with non-malignant cells...
November 18, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29148641/ganglioneuroma-of-the-neck-a-case-report
#3
Woubedel Kiflu, Tihitena Negussie
Ganglioneuroma (GN) is benign tumor arising from sympathetic ganglion which commonly occurs at posterior mediastinum, retroperitoneum and adrenal gland. Rarely, it may also present in cervical region as slow growing painless neck mass. Here we present a 7 years old female child with 4 years duration of slow growing left lateral neck mass. After proper investigations the patient was prepared & taken to the operation room for complete excision of the mass. Post operation biopsy settled the definitive diagnosis as Ganglioneuroma...
January 2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/29147608/the-prognostic-role-of-tumor-infiltrating-t-lymphocytes-in-squamous-cell-carcinoma-of-the-head-and-neck-a-systematic-review-and-meta-analysis
#4
REVIEW
Emma J de Ruiter, Marc L Ooft, Lot A Devriese, Stefan M Willems
Background - The presence of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment is associated with an improved prognosis and a better response to therapy in different types of cancer. In this systematic review and meta-analysis, we investigated the prognostic value of T cells in head and neck squamous cell carcinoma (HNSCC). Methods - In a systematic review, Pubmed and Embase were searched for publications that investigated the prognostic value of T cells in HNSCC. A meta-analysis was performed including all studies assessing the association between CD3+, CD4+, CD8+, and FoxP3+ TILs and overall survival (OS), disease-free survival (DFS), or locoregional control (LRC)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29147602/gdnf-secreted-by-nerves-enhances-pd-l1-expression-via-jak2-stat1-signaling-activation-in-hnscc
#5
Chengzhong Lin, Wei Cao, Zhenhu Ren, Yu Tang, Chunye Zhang, Rong Yang, Yiming Chen, Zheqi Liu, Canbang Peng, Lizhen Wang, Xu Wang, Tong Ji
Programmed death ligand 1 (PD-L1) functions as a key immune inhibitory factor by binding with its receptor, programmed death 1 (PD-1), to induce immune cell dysfunction and escape of the immune system. However, the mechanisms of PD-L1 expression under growth factor stimulation are not well characterized. Here, we demonstrate a novel role for glial cell line-derived neurotrophic factor (GDNF) in upregulating PD-L1 expression in head and neck squamous cell carcinoma (HNSCC). The expression and correlation of PD-L1, GDNF and perineural invasion (PNI) status were evaluated by bioinformatics analysis of TCGA database and IHC assays from 145 HNSCC patients...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29147595/synchronous-ganglioneuroma-and-schwannoma-mistaken-for-carotid-body-tumor
#6
Konstantinos Paraskevopoulos, Angeliki Cheva, Styliani Papaemmanuil, Konstantinos Vahtsevanos, Konstantinos Antoniades
Ganglioneuromas are a very rare benign neural tumor, commonly derived from the ganglia of the sympathetic system, and are composed of mature Schwann cells, ganglion cells, and nerve fibres. They may arise anywhere from the base of the skull to the pelvis along the paravertebral sympathetic plexus. We report a rare case of synchronous ganglioneuroma and schwannoma, mistaken for carotid body tumor. The coexistence of these two entities in head and neck region is very rare.
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29145292/recurrent-spinal-primitive-neuroectodermal-tumor-with-brain-and-bone-metastases-a-case-report
#7
Frank Chen, Shyh-Shin Chiou, Sheng-Fung Lin, Ann-Shung Lieu, Yi-Ting Chen, Chih-Jen Huang
RATIONALE: Primary spinal primitive neuroectodermal tumor (PNET) is relatively rare in all age groups, and the prognosis in most cases of spinal PNETs appears to be poor, with a median patient survival of 1 to 2 years. We present a case with recurrent spinal PNET with brain and bone metastases that was successfully treated by multimodality treatment. PATIENT CONCERNS: A 14-year-old teenage girl had suffered from progressive left upper back pain with bilateral lower legs weakness and numbness for 1 year...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144820/pheochromocytoma-a-genetic-and-diagnostic-update
#8
Leilani B Mercado-Asis, Katherine I Wolf, Ivana Jochmanova, David Taïeb
OBJECTIVE: Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors derived from adrenal or extra-adrenal locations, respectively. Upon suspicion of PPGL, specific metabolomic, molecular, biochemical, imaging, and histopathological studies are performed to prove, localize, treat, and monitor disease progression. Recently, improved diagnostic tools allow physicians to accurately diagnose PPGL, even in patients presenting with small (less than 1 cm) or biochemically silent tumors, which previously delayed proper detection and treatment...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143362/microrna-26a-inhibits-proliferation-and-tumorigenesis-via-targeting-cks2-in-laryngeal-squamous-cell-carcinoma
#9
Zhiyan Wu, Baocai Lu, Xiao Li, Wenjie Miao, Jin Li, Yongjuan Shi, Wenfa Yu
Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck cancer, with high mortality and incidence. MicroRNA-26a (miR-26a) is involved in the development and progression of several tumors. However, the roles of miR-26a and its target CKS2 in LSCC progression are not yet clear. The mRNA and protein expression was determined using RT-PCR and Western blotting assay, respectively. Cell proliferation was detected using a Cell Counting kit-8 assay (CCK-8). Transwell assay was used to evaluate cell migration and invasion...
November 16, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29142854/skin-metastasis-on-the-neck-an-unusual-presentation-of-recurrence-of-papillary-thyroid-carcinoma
#10
Selen Soylu, Akif Enes Arikan, Serkan Teksoz, Murat Ozcan, Yusuf Bukey
Skin metastasis of papillary thyroid carcinoma (PTC) is rare. Here, two cases of skin metastases of PTC are presented. Both of the patients were females, one is 83 and the other is 65 years old. The patients were admitted to the hospital with a movable skin lesion on anterior neck region. Free T3 and T4 levels were in normal levels and TSH levels were low in both patients. The 83-year-old patient underwent total thyroidectomy due to papillary thyroid cancer and received (131)I ablation therapy and then thyroid suppression therapy...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142772/rare-case-of-an-extraosseous-cervical-chordoma-with-both-intradural-and-extensive-extraspinal-involvement
#11
Victor Awuor, Christopher E Stewart, Albert Camma, Julie Renner, J M Tongson
Background: Chordomas must be considered among the differential diagnoses for extradural spinal tumors, especially involving the clival or sacrococcygeal regions. They are often locally invasive and destructive to the osseous structures from which they arise, but rarely extend intradurally. Here, we report a unique chordoma that was intradural and spanned nearly four subaxial cervical vertebral levels. Case Description: We report the case of an atypical intradural chordoma that spanned four subaxial levels of the cervical spine in an 81-year-old female...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29142746/interaction-between-merkel-cell-carcinoma-and-the-immune-system-pathogenetic-and-therapeutic-implications
#12
Irene Zanetti, Ilaria Coati, Mauro Alaibac
Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine carcinoma. It usually appears on the face and neck of elderly Caucasian people as a flesh-colored, erythematous or violaceous dome-shaped, non-tender nodule with a smooth surface. In immunocompromised patients with T-cell dysfunction, such as patients with acquired immunodeficiency syndrome (AIDS) or solid organ transplant recipients, the incidence of this disease is markedly increased. This suggests a link between the development of MCC and the immune system...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29142463/management-of-extramedullary-plasmacytoma-role-of-radiotherapy-and-prognostic-factor-analysis-in-55-patients
#13
Ge Wen, Weihu Wang, Yujing Zhang, Shaoqing Niu, Qiwen Li, Yexiong Li
Objective: To investigate potential prognostic factors affecting patient outcomes and to evaluate the optimal methods and effects of radiotherapy (RT) in the management of extramedullary plasmacytoma (EMP). Methods: Data from 55 patients with EMP between November 1999 and August 2015 were collected. The median age was 51 (range, 22-77) years. The median tumor size was 3.5 (range, 1.0-15.0) cm. The median applied dose was 50.0 (range, 30.0-70.0) Gy. Thirty-nine patients (70...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29142161/treatment-and-outcomes-of-carcinoma-of-the-external-and-middle-ear-the-validity-of-en-bloc-resection-for-advanced-tumor
#14
Takuma Matoba, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Eiji Tachibana, Takeshi Okada, Shingo Murakami, Yasuhisa Hasegawa
Carcinoma of the external and middle ear is a very rare disease. Despite the various treatment modalities available, its prognosis is still poor. We aimed to analyze the treatment modalities, outcomes, and validity of surgical approaches, especially in advanced tumors in the ear. Twenty-five patients with carcinoma of the external and middle ear were retrospectively analyzed. The modified Pittsburgh staging system was used for staging of the patients. Overall and disease-free survival was estimated using of Kaplan-Meier method...
November 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29141291/-peripheral-blood-circulating-tumor-cells-in-local-advanced-head-and-neck-squamous-cell-carcinoma
#15
J L Lou, L Guo, W H Zheng, J Z Zhao, J Q Zhao, Z Liang, S Y Wang, M Y Fang
Objective: To investigate the value of detecting circulating tumor cells (CTCs) in patients with local advanced head and neck squamous cell carcinoma (LAHNSCC). Methods: Twenty cases of LAHNSCC and eight healthy cases as the negative control were collected. The clinicopathological factors were evaluated. The LAHNSCC CTCs were enriched by specific antibody nanofluidic chip immunoassay using CytoSorter CTCs sorting system. LAHNSCC CTCs were identified by immunofluorescence staining. The relationships between CTCs and the clinicopathological features of LAHNSCC were analyzed...
November 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29140965/long-term-hearing-preservation-after-resection-of-vestibular-schwannoma-a-systematic-review-and-meta-analysis
#16
Syed F Ahsan, Farhan Huq, Michael Seidman, Andrew Taylor
OBJECTIVE: The objective is to perform a systematic review and meta-analysis of the literature on the long-term results of hearing preservation after vestibular schwannoma resection. DATA SOURCES: Ovid/Medline, PubMed, Embase, and the Cochrane library from January 1980 to January 2015. STUDY SELECTION: Inclusion criteria: age ≥18 years, minimum 10 patients in the treatment group, hearing preserving microsurgery, no previous radiation treatment, serviceable hearing at immediate postop follow-up, hearing outcomes reported using Gardner Robinson or the American Academy of Otolaryngology-Head and Neck Surgeons hearing grading scales, and average follow-up of 5 years...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29139089/cancer-stem-cells-in-head-and-neck-carcinomas-identification-and-possible-therapeutic-implications
#17
Elize Wolmarans, Sonja C Boy, Sulette Nel, Anne E Mercier, Michael Sean Pepper
The recurrence and/or lack of response of certain tumors to radio- and chemotherapy has been attributed to a small subpopulation of cells termed cancer stem cells (CSCs). CSCs have been identified in many tumors (including solid and hematological tumors). CSCs are characterized by their capacity for self-renewal, their ability to introduce heterogeneity within a tumor mass and its metastases, genomic instability, and their insensitivity to both radiation and chemotherapy. The latter highlights the clinical importance of studying this subpopulation since their resistance to traditional treatments may lead to metastatic disease and/or tumor relapse...
November 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29138797/activation-of-adrenergic-receptor-%C3%AE-2-promotes-tumor-progression-and-epithelial-mesenchymal-transition-in-tongue-squamous-cell-carcinoma
#18
Haichao Liu, Cheng Wang, Nan Xie, Zehang Zhuang, Xiqiang Liu, Jinsong Hou, Hongzhang Huang
Tongue squamous cell carcinoma (TSCC) is more aggressive than other cancers in the head and neck region because of its potential for metastasis. Recently, β2‑adrenergic receptor (β2‑AR) has been reported to be a potential promoter in various types of solid cancer. However, the role of β2‑AR and its effect on TSCC is not well documented. Histological staining, western blot analysis, migration and invasion assay were used. In this study, the expression of β2‑AR was increased in TSCC tissue compared with adjacent non‑cancerous epithelium...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29138659/-lymphangioma-of-the-breast-about-a-case
#19
Eric Mbuya Musapudi, Aimé Lukoba Bwalya, Igor Mujinga Wa Mujinga, Didier Tshibangu Mujinga, Julien Ilunga Nikulu, Guy Nday Ilunga
Lymphangioma is a benign lesion of the lymphatic vessels. It is a rare paediatric condition and it is exceptional among adults. It mainly occurs in the neck, armpit and abdomen. It rarely occurs in the breast. We report the case of a 18 year-old female patient seen in consultation for a mass in her left breast, which had evolved over the last 23 months. Management was based on surgery. The patient underwent complete tumor resection. Anatomopathological examination showed lymphangioma of the breast. Patient's evolution was favorable and the patient had a median 10 months follow-up with no recurrences identified...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29138574/cancer-cell-dormancy-mechanisms-and-implications-of-cancer-recurrence-and-metastasis
#20
REVIEW
Xiao-Lei Gao, Mei Zhang, Ya-Ling Tang, Xin-Hua Liang
More recently, disease metastasis and relapse in many cancer patients several years (even some decades) after surgical remission are regarded as tumor dormancy. However, the knowledge of this phenomenon is cripplingly limited. Substantial quantities of reviews have summarized three main potential models that can be put forth to explain such process, including angiogenic dormancy, immunologic dormancy, and cellular dormancy. In this review, newly uncovered mechanisms governing cancer cell dormancy are discussed, with an emphasis on the cross talk between dormant cancer cells and their microenvironments...
2017: OncoTargets and Therapy
keyword
keyword
96390
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"