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https://www.readbyqxmd.com/read/29330865/a-case-of-radiation-induced-osteosarcoma-of-the-skull-presenting-as-a-cutaneous-epidermotropic-tumour-with-a-short-latent-period
#1
E Rashidghamat, E Calonje
Radiation induced sarcoma is an unusual but well documented tumor. The frequency of radiation induced sarcoma of the head and neck region has been reported as 0.143%. In the literature the median interval between irradiation and development of sarcoma is 11 years. Cases of RIS with a short latent period i.e. less than four years are rare. We report a case of a 34 year-old female who developed an osteosarcoma of the scalp, over a previous craniotomy scar, three years after excision of a frontal anaplastic oligodendroglioma which had been followed by a course of 6 weeks radiotherapy (58 Gy) and 6 cycles of Temozolomide...
January 13, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29330429/tissue-and-serum-microrna-profile-of-oral-squamous-cell-carcinoma-patients
#2
Augusto Schneider, Berta Victoria, Yury Nunez Lopez, Wiktoria Suchorska, Wojciech Barczak, Agnieszka Sobecka, Wojciech Golusinski, Michal M Masternak, Pawel Golusinski
Head and neck cancer is characterized by malignant tumors arising from the epithelium covering the upper aerodigestive tract, and the majority of these epithelial malignancies are squamous cell carcinomas (SCCs) of the oral cavity (OSCCs). The aim of the current work was to identify miRNAs regulated in OSCC cancerous tissue when compared to a healthy adjacent tissue and to verify the presence of the same miRNAs in the circulation of these patients. For that serum samples and biopsies of healthy and tumor tissues were collected from five patients diagnosed with OSCC of the oral cavity, RNA was extracted from these samples and microRNAs libraries were prepared and sequenced...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329129/primary-cutaneous-spindle-cell-squamous-carcinoma-expressing-smooth-muscle-actin-diagnostic-pitfalls
#3
Abdullahi Ahmad, Hye Jin Chung, Jag Bhawan
Alpha smooth muscle actin (SMA) belongs to the actin proteins. It is a known immunohistochemical marker for tumors of mesenchymal origin. There have been reports of expression of SMA in certain epithelial malignancies in the head and neck and genital regions. In this study, the authors report a primary cutaneous spindle cell squamous carcinoma expressing SMA. Both high- and low-molecular-weight keratins and p63 were positive, and S100 protein, SOX10, MART-1/Melan-A, and muscle-specific actin stains were negative...
January 11, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29329114/synovial-sarcomas-of-the-upper-aero-digestive-tract-is-there-a-role-for-conservative-surgery
#4
Alberto Paderno, Alessandro Gronchi, Cesare Piazza
PURPOSE OF REVIEW: To present the current state of knowledge concerning the role of conservative surgery in the treatment of synovial sarcomas of the upper aero-digestive tract (UADT). RECENT FINDINGS: The wider experience on synovial sarcomas involving the extremities and the results of retrospective reports focused on head and neck synovial sarcomas tend to justify a conservative surgical approach when dealing with tumors involving the UADT. SUMMARY: UADT synovial sarcomas is an extremely rare clinical entity (only around 50 cases reported in the literature, with four more herein presented from our own surgical series), with no clear guidelines concerning its treatment...
January 11, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29327683/clinical-manifestation-of-malignant-lymphomas-of-the-head-and-neck-region
#5
Katarzyna Bojanowska-Poźniak, Monika Nurkowska, Marian Danilewicz, Wioletta Pietruszewska
INTRODUCTION: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL), with numerous subtypes. The majority of MLs are localized in lymph nodes, but extranodal locations are also possible. MLs represent approximately 3-5% of all malignant neoplasms in Poland, but their incidence has been increasing in recent years, especially in young patients...
December 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29327682/analysis-of-implementiation-of-4th-head-and-neck-cancer-awareness-week-in-department-of-otolaryngology-in-mi%C3%A4-dzyleski-hospital-in-warsaw
#6
Karolina Dżaman, Karolina Piskadło-Zborowska, Mirosława Pietniczka-Załęska
INTRODUCTION: The aim of the study was to analyze the profile of patients applying for free preventive examinations within The Forth European Head an Neck Cancer (HNC) Awareness Week in the Department of Otorhynolaryngology in Międzyleski Hospital in Warsaw (ORL MSS). MATERIAL AND METHODS: A media campaign was designed to inform HNC risk patients about the opportunity to receive free preventive examinations in ORL MSS. 225 patients were enrolled to the study. Patient age ranged from 26 to 92 (average 63 years)...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29325948/spinal-metastasis-resulting-from-atypical-thymic-carcinoid-a-case-report
#7
Xinjie Wu, Yingna Qi, Feng Yang, Mingsheng Tan, Jie Lin
BACKGROUND: Thymic carcinoid with spinal metastasis is an extremely rare entity. Clinically, the tumor presents either by its endocrine manifestations or by mechanical compression of surrounding structures. However, no previous studies reported a case with neck pain, and neurological deficit as initial presentation of an atypical thymic carcinoid. METHOD: A 56-year-old non-smoking man presented with 12-month history of intermittent neck pain and 1-month history of progressive numbness and weakness of the right upper limb...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325590/dynamic-changes-in-18f-borono-l-phenylalanine-uptake-in-unresectable-advanced-or-recurrent-squamous-cell-carcinoma-of-the-head-and-neck-and-malignant-melanoma-during-boron-neutron-capture-therapy-patient-selection
#8
Takahiro Morita, Hiroaki Kurihara, Kenta Hiroi, Natsuki Honda, Hiroshi Igaki, Jun Hatazawa, Yasuaki Arai, Jun Itami
BACKGROUND: We evaluated dynamic changes in 18F-borono-L-phenylalanine (18F-BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neutron capture therapy (BNCT) patient selection. METHODS: Dynamic changes in the maximum standardized uptake value (SUVmax), tumor-to-normal tissue ratio (TNR), and tumor-to-blood pool ratio (TBR) for 18F-BPA were evaluated in 20 patients with SCC and 8 patients with MM...
January 11, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29325506/clinical-impact-of-detectable-antithyroglobulin-antibodies-below-the-reference-limit-borderline-in-patients-with-papillary-thyroid-carcinoma-with-negative-serum-thyroglobulin-and-neck-ultrasonography-after-ablation-a-prospective-study
#9
Marina Carvalho, Pedro Weslley Rosario, Gabriela Franco Mourão, Luis Fernando Faria Oliveira, Maria Regina Calsolari
BACKGROUND: Interference of antithyroglobulin antibodies (TgAb) with serum thyroglobulin (Tg) can occur even at detectable TgAb concentrations below the reference limit (borderline TgAb). Thus, borderline TgAb is considered positive TgAb in patients with thyroid cancer. This prospective study evaluated patients with papillary thyroid carcinoma with negative Tg and neck ultrasonography (US) after initial therapy and compared tumor persistence/recurrence and long-term Tg and TgAb behavior in those with borderline versus undetectable TgAb...
January 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29325251/-extrapleural-solitary-fibrous-tumor-with-uncommon-histology-a-clinicopathologic-analysis-of-7-cases
#10
M Zhao, Z R Yang, Y B Wang, Y Chen, G W Qi, Y J Yan, W J Xu, G Q Ru, X L He
Objective: To investigate the clinicopathologic characteristics, immunophenotypes, and differential diagnostic features of extra-pleural solitary fibrous tumor (SFT) with uncommon histology. Methods: Seven cases of extra-pleural SFT with uncommon histology were collected during January 2015 and December 2016 in Zhejiang Provincal People's Hospital; the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed. EnVision method was used for immunohistochemical staining of STAT6, CD34 and other differential diagnosis associated markers...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29325250/-myofibroma-myofibromatosis-a-clinicopathologic-analysis-of-9-cases
#11
Y Fu, W Y Guan, H Y Wu, H Y Wu, Z W Fan, Q Ye, F Q Meng
Objective: To investigate the clinical and histological features, diagnosis and differential diagnosis of myofibroma/myofibromatosis. Methods: The clinical data and pathology features of nine cases of myofibroma/myofibromatosis were collected from August 2011 to November 2016 in Affiliated Drum Tower Hospital, Nanjing University Medical School and Children's Hospital of Nanjing Medical University. Immunohistochemistry(IHC), PDGFRB molecular analysis and ETV6-NTRK3 gene fusion were performed and relevant literature reviewed...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29323421/head-and-neck-cancer-tumor-seeding-at-the-percutaneous-endoscopic-gastrostomy-site
#12
REVIEW
June R Greaves
The National Institutes of Health National Cancer Institute estimates that over 13,000 new cases of head and neck cancer (HNC) will be diagnosed in 2017. Patients with HNC often require enteral nutrition (EN) via gastrostomy tube to provide nutrition support and hydration because of tumor obstruction of the oropharynx and/or cumulative effects of chemoradiation therapy. The percutaneous endoscopic gastrostomy (PEG) tube has become the preferred technique for EN access because placement is considered a minimally invasive procedure...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29323141/comparison-long-term-outcome-of-definitive-radiotherapy-plus-different-chemotherapy-schedules-in-patients-with-advanced-nasopharyngeal-carcinoma
#13
Yi-Chun Liu, Wen-Yi Wang, Chih-Wen Twu, Rong-San Jiang, Kai-Li Liang, Po-Ju Lin, Jing-Wei Lin, Jin-Ching Lin
Concurrent chemoradiotherapy (CCRT) is the current standard of care for advanced nasopharyngeal carcinoma (NPC). We hypothesize that shifting CCRT to neoadjuvant chemotherapy followed by radiotherapy (NeoCT-RT) is an alternative option. From December 2004 to January 2009, 256 NPC patients with stage II-IVB were treated by either CCRT or NeoCT-RT. All patients received the same dosage and fractionation schedule of RT. After long-term follow-up, 26.8% (34/127) and 23.3% (30/129) of patients who received CCRT and NeoCT-RT respectively, developed a tumor relapse (P = 0...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323108/clinical-study-of-tuberculosis-in-the-head-and-neck-region-11-years-experience-and-a-review-of-the-literature
#14
Pai Pang, Weiyi Duan, Shuchun Liu, Shuang Bai, Yanan Ma, Ruiwu Li, Fayu Liu, Changfu Sun
Tuberculosis (TB) is an infectious disease and major health concern. Head and neck tuberculosis (HNTB) is relatively rare, but can arise in many regions, including the lymph nodes, larynx, oral cavity and pharynx. We retrospectively reviewed the clinical records of 60 patients diagnosed with HNTB in our department between March 2005 and January 2016. A review and summary of previous HNTB articles published in PubMed since 1885 was also performed. The subjects consisted of 17 males and 43 females, and the average age of patients was 45 ± 14...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29322881/radiofrequency-ablation-of-primary-thyroid-carcinoma-efficacy-according-to-the-types-of-thyroid-carcinoma
#15
So Yeong Jeong, Jung Hwan Baek, Young Jun Choi, Sae Rom Chung, Tae Yon Sung, Won Gu Kim, Tae Yong Kim, Jeong Hyun Lee
OBJECTIVE: To evaluate the efficacy of ultrasound (US)-guided radiofrequency ablation (RFA) according to the types of thyroid carcinoma, particularly in patients with a high surgical risk. MATERIALS AND METHODS: Eight patients with nine tumors of pathologically proven papillary and anaplastic carcinoma were treated by US-guided RFA. Patients with primary thyroid carcinoma were divided into three groups; group 1: Anaplastic carcinoma, group 2: papillary macrocarcinoma, and group 3: papillary microcarcinoma...
January 11, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29322269/prognostic-value-of-simultaneous-18f-fdg-pet-mri-using-a-combination-of-metabolo-volumetric-parameters-and-apparent-diffusion-coefficient-in-treated-head-and-neck-cancer
#16
Yong-Il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee, June-Key Chung
BACKGROUND: The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for the prediction of treatment failure in surgically resected head and neck cancer. We hypothesized that PET parameters corrected by tumor cellularity (combined PET/MRI parameters) could predict the prognosis. On regional PET, maximum standardized uptake value (SUVmax) was measured as metabolic parameters...
January 10, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29321813/novel-concept-of-a-modular-hip-implant-could-contribute-to-less-implant-failure-in-tha-a-hypothesis
#17
Ronny Grunert, Stefan Schleifenbaum, Robert Möbius, Michael Kopper, Christian Rotsch, Welf-Guntram Drossel, Niels Hammer, Torsten Prietzel
Background: The modularity in total hip arthroplasty (THA) allows orthopaedic surgeons for an exact reconstruction of hip biomechanical parameters especially in revision and tumor arthroplasty. Modular structured femoral stems using taper junctions showed increased implant breakage in the recent past. Presentation of the hypothesis: We hypothesize that a novel modular stem-neck-interface leads to less implant breakage compared to conventional femoral stems. Testing of the hypothesis: For this purpose, a novel modular femoral stem for THA was to design and manufacture...
2018: Patient Safety in Surgery
https://www.readbyqxmd.com/read/29320320/mr-imaging-and-cochlear-implants-with-retained-internal-magnets-reducing-artifacts-near-highly-inhomogeneous-magnetic-fields
#18
Heidi A Edmonson, Matthew L Carlson, Alice C Patton, Robert E Watson
The number of patients receiving cochlear implants and auditory brainstem implants for severe to profound sensorineural hearing loss has rapidly increased. These implants consist of an internal component implanted between the skull and the temporal scalp and an external removable speech processor unit. A small magnet within the internal component is commonly used to hold the external speech processor unit in place. Several cochlear implant models have recently received U.S. Food and Drug Administration and European Economic Area regulatory approval to allow magnetic resonance (MR) imaging examinations to be performed under certain specified conditions...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29319130/anaplastic-thyroid-carcinoma-with-rapid-thyrotoxicosis-case-report-and-the-review-of-literature
#19
Jacek Daroszewski, Katarzyna Paczkowska, Aleksandra Jawiarczyk-Przybyłowska, Marek Bolanowski, Michał Jeleń
INTRODUCTION: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of malignant neoplasms of thyroid. ATC usually presents with local symptoms due to rapidly enlarging thyroid mass, and has only seldom been reported to be a cause of thyrotoxicosis. Up to date only 9 cases of ATC presented with thyrotoxicosis have been described. CASE REPORT: We report a case of 66-year-old woman, who had had a large, euthyroid multinodular goiter for almost 50 years...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29317966/epithelioid-angiosarcoma-in-femur-a-case-presentation
#20
Yunus Oc, Bekir Eray Kilinc, Rodi Ertugrul, Hasan Basri Sezer, Osman Tugrul Eren
Primary malignant vascular tumors which constitute less than 1% of the primary bone tumors are very rarely encountered. Epithelioid angiosarcoma is a very uncommon subtype of angiosarcomas presenting with an epithelioid phenotype and mimicking carcinomas clinically. These tumors select mostly extra-skeletal locations but rarely bones as their medium. A 31-year-old male patient applied to our clinic with a nonspecific left hip pain. X-ray evaluation revealed a cystic expansile mass in the trochanteric region of the femur extending to the femoral neck...
December 2017: World Journal of Oncology
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