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https://www.readbyqxmd.com/read/28549377/biocompatibility-of-liposome-nanocarriers-in-the-rat-inner-ear-after-intratympanic-administration
#1
Jing Zou, Hao Feng, Rohit Sood, Paavo K J Kinnunen, Ilmari Pyykko
Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration. However, information on the biocompatibility of LPNs in the inner ear is lacking. The aim of the present study is to document the biocompatibility of LPNs in the inner ear after intratympanic delivery. LPNs with or without gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) were delivered to the rats through transtympanic injection...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28548978/frontline-managers-we-want-to-hear-about-you-2017-richard-hader-visionary-leader-award
#2
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Nursing Management
https://www.readbyqxmd.com/read/28548616/pediatric-superior-semicircular-canal-dehiscence-illustrative-case-and-systematic-review
#3
Carlito Lagman, Vera Ong, Lawrance K Chung, Lekaa Elhajjmoussa, Christina Fong, Anthony C Wang, Quinton Gopen, Isaac Yang
OBJECTIVE The purpose of this study is to present an illustrative case of pediatric superior semicircular canal dehiscence (SSCD) and to systematically review the current published literature in the pediatric population. METHODS An electronic search of the Scopus, Web of Science, PsycINFO, Cochrane, and Embase databases was performed by 2 independent authors through January 2017. Search term combinations included "pediatrics," "children," "canal," and "dehiscence." Inclusion criteria were as follows: English, full-text clinical studies, case reports, and case series describing pediatric patient(s) (younger than 18 years) with CT evidence of SSCD...
May 26, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28547010/language-development-and-impairment-in-children-with-mild-to-moderate-sensorineural-hearing-loss
#4
Lorna F Halliday, Outi Tuomainen, Stuart Rosen
Purpose: The goal of this study was to examine language development and factors related to language impairments in children with mild to moderate sensorineural hearing loss (MMHL). Method: Ninety children, aged 8-16 years (46 children with MMHL; 44 aged-matched controls), were administered a battery of standardized language assessments, including measures of phonological processing, receptive and expressive vocabulary and grammar, word and nonword reading, and parental report of communication skills...
May 24, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28546977/how-much-elderly-people-of-isfahan-are-adherent-to-their-drug-therapy-regimens
#5
Parvaneh Abazari, Tayebe Arab Jafari, Ali Mohammad Sabzghabaee
BACKGROUND: The need for a correct follow-up for medical advices of health givers is the cornerstone for avoiding drug-related complications in especial period of elderly people life. There isn't any data about drug therapy regimens adherence of elderly people of Isfahan. In this study, we aimed to cover this deficit. MATERIALS AND METHODS: In this cross-sectional study which was carried out in Isfahan (Iran) in 2013 senior citizens (aged 65 or more) who were taking at least one medication and had no record of residency in nursing homes were included...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28546963/auditory-processing-abilities-of-parkinson-s-disease-patients
#6
Robert L Folmer, Jay J Vachhani, Sarah M Theodoroff, Rachel Ellinger, Amy Riggins
Since Parkinson's Disease (PD) primarily affects older people, a majority of PD patients have age-related hearing loss (HL) that will worsen over time. The goal of this study was to assess peripheral and central auditory functions in a population of PD patients and compare the results with a group of age-matched control subjects. Study participants included 35 adults with PD (mean age = 66.9 ± 11.2 years) and a group of 35 healthy control subjects (mean age = 65.4 ± 12.3 years). Assessments included questionnaires, neuropsychological tests, audiometric testing, and a battery of central auditory processing tests...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28546251/mr-imaging-in-sudden-sensorineural-hearing-loss-time-to-talk
#7
G Conte, F Di Berardino, C Sina, D Zanetti, E Scola, C Gavagna, L Gaini, G Palumbo, P Capaccio, F Triulzi
Sudden sensorineural hearing loss is defined as acute hearing loss of the sensorineural type of at least 30 dB over 3 contiguous frequencies that occurs within a 72-hour period. Although many different causative factors have been proposed, sudden sensorineural hearing loss is still considered "idiopathic" in 71%-85% of cases, and treatments are empiric, not based on etiology. MR imaging implemented with a 3D FLAIR sequence has provided new insights into the etiology of sudden sensorineural hearing loss. Herein, we review the current management trends for patients with sudden sensorineural hearing loss, from the initial clinical diagnosis to therapeutic strategies and diagnostic work-up...
May 25, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28545994/the-impact-of-atypical-sensory-processing-on-social-impairments-in-autism-spectrum-disorder
#8
REVIEW
Melissa D Thye, Haley M Bednarz, Abbey J Herringshaw, Emma B Sartin, Rajesh K Kana
Altered sensory processing has been an important feature of the clinical descriptions of autism spectrum disorder (ASD). There is evidence that sensory dysregulation arises early in the progression of ASD and impacts social functioning. This paper reviews behavioral and neurobiological evidence that describes how sensory deficits across multiple modalities (vision, hearing, touch, olfaction, gustation, and multisensory integration) could impact social functions in ASD. Theoretical models of ASD and their implications for the relationship between sensory and social functioning are discussed...
May 17, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28545498/feasibility-of-a-systematic-comprehensive-one-to-one-training-scoot-program-for-new-scooter-users-study-protocol-for-a-randomized-control-trial
#9
W Ben Mortenson, Sharon Jang, Charlie H Goldsmith, Laura Hurd Clarke, Sandra Hobson, Richelle Emery
BACKGROUND: Mobility scooters can facilitate community participation among individuals with mobility limitations. However, accidents are a serious concern with scooter use. Scooter training has been recommended to improve safety, but there are currently few validated programs available. Therefore, we developed a Systematic, Comprehensive, One-to-One Training (SCOOT) program for scooter users. We will conduct a study to evaluate the outcomes produced by the provision SCOOT. METHODS: This feasibility study will use a mixed-methods, rater-blinded, randomized control trial, with a two-step wedge design...
May 25, 2017: Trials
https://www.readbyqxmd.com/read/28545070/pou4f3-mutation-screening-in-japanese-hearing-loss-patients-massively-parallel-dna-sequencing-based-analysis-identified-novel-variants-associated-with-autosomal-dominant-hearing-loss
#10
Tomohiro Kitano, Maiko Miyagawa, Shin-Ya Nishio, Hideaki Moteki, Kiyoshi Oda, Kenji Ohyama, Hiromitsu Miyazaki, Hiroshi Hidaka, Ken-Ichi Nakamura, Takaaki Murata, Rina Matsuoka, Yoko Ohta, Nobuhiro Nishiyama, Kozo Kumakawa, Sakiko Furutate, Satoshi Iwasaki, Takechiyo Yamada, Yumi Ohta, Natsumi Uehara, Yoshihiro Noguchi, Shin-Ichi Usami
A variant in a transcription factor gene, POU4F3, is responsible for autosomal dominant nonsyndromic hereditary hearing loss, DFNA15. To date, 14 variants, including a whole deletion of POU4F3, have been reported to cause HL in various ethnic groups. In the present study, genetic screening for POU4F3 variants was carried out for a large series of Japanese hearing loss (HL) patients to clarify the prevalence and clinical characteristics of DFNA15 in the Japanese population. Massively parallel DNA sequencing of 68 target candidate genes was utilized in 2,549 unrelated Japanese HL patients (probands) to identify genomic variations responsible for HL...
2017: PloS One
https://www.readbyqxmd.com/read/28544941/time-based-expectations-entail-preparatory-motor-activity
#11
Gregor Volberg, Roland Thomaschke
Human behavior is guided by expectations that facilitate perception of upcoming events or reaction to them. In natural settings expectations are often implicitly based on time, e.g., when making a phone call one would expect to hear either a person answering (earlier) or a voicemail greeting (later). We investigated how time-based expectations can improve performance in the absence of explicit prior information on the pending stimulus or the associated response. Visual stimuli were presented after a characteristic short or long foreperiod, and a forced-choice categorization using either the left or the right hand was required...
May 4, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28544920/acquisition-of-who-question-comprehension-in-german-children-with-hearing-loss
#12
Eva Wimmer, Monika Rothweiler, Martina Penke
For children with sensorineural hearing loss the ability to understand wh-questions might be particularly challenging because they often have only restricted access to spoken language input during optimal periods of language acquisition. In previous research it has been suggested that this restricted input during critical stages in language acquisition might lead to syntactic deficits that persist into adolescence. In this study we want to pursue this issue by investigating the comprehension of wh-questions in German children with bilateral sensorineural hearing loss...
May 13, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28544707/the-use-of-co2-laser-in-skin-complications-following-baha-implantation-our-experience-in-the-eight-patients
#13
Maciej Sokola, Katarzyna Malec, Pawel Brzewski, Pawel Dobosz
1 Skin reactions are the most common complications after BAHA implantation. 2 The excess of soft tissue leads to inability to tack the hearing ad to the abutment which prevents the effective use of sound processor. 3 This is a prospective case series of 8 patients with skin overgrowth around the BAHA abutments treated with CO2 laser. 4 This case-series suggest that CO2 laser is safe and easy method for the treatment of the skin overgrowth around the BAHA abutment. 5 This is the first case series presentation of the CO2 laser surgery for treatment of the skin overgrowth around the abutment of BAHA This article is protected by copyright...
May 22, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28544249/37th-annual-david-w-smith-workshop-on-malformations-and-morphogenesis-abstracts-of-the-2016-annual-meeting
#14
Kim M Keppler-Noreuil, Julian A Martinez-Agosto, Louanne Hudgins, John C Carey
The 37th Annual David W. Smith Workshop on Malformations and Morphogenesis occurred on September 9th-14th, 2016 at the University of California-Los Angeles Conference Center in Lake Arrowhead, CA. The Workshop, which honors the legacy of David W. Smith, brought together clinicians and researchers interested in congenital malformations and their underlying mechanisms of morphogenesis. The Workshop highlighted five themes besides mechanisms of morphogenesis and New Syndromes: Neural Crestopathies, Mosaicism, Disorders of Skin Pigmentation, Therapies, and Ear Malformations and Hearing Loss...
May 24, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28543437/the-adenoid-its-history-and-a-cautionary-tale
#15
Robert J Ruben
The existence of the adenoid first appears to have been noted by Conrad Victor Schneider in 1661. James Yearsley reported in 1842 one case in which he improved hearing by removal of a mucus membrane from behind the uvula, which indicates some appreciation of a relationship of the nasopharynx to ear disease. Hans Wilhelm Meyer, in 1868, was the first to demonstrate the relationship of the adenoid to ear disease and to develop an effective, although somewhat difficult, surgical operation to remove the adenoid...
June 2017: Laryngoscope
https://www.readbyqxmd.com/read/28543270/acoustic-plus-electric-speech-processing-long-term-results
#16
Bruce J Gantz, Camille C Dunn, Jacob Oleson, Marlan R Hansen
OBJECTIVE: Few studies have investigated the stability of residual hearing and speech perception outcomes in individuals who were implanted with a shorter electrode device. STUDY DESIGN: Longitudinal, single-subject design. METHODS: Fifty subjects who received a Nucleus Hybrid (Cochlear, Sydney, Australia) short electrode cochlear implant (CI) and had a minimum of 2 years (and up to 15 years) of postoperative longitudinal experience were included in this study...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28543174/endoscopic-transcanal-approach-to-the-middle-ear-for-management-of-pediatric-cholesteatoma
#17
Saied Ghadersohi, John M Carter, Stephen R Hoff
OBJECTIVES: To describe outcomes for endoscopic ear surgery (EES) for pediatric cholesteatoma at a tertiary pediatric hospital. METHODS: Retrospective case series of 65 pediatric cholesteatoma cases in 38 ears. Subgrouping based on cholesteatoma type and EES type. Surgical findings, outcomes, and demographic data were evaluated. RESULTS: Endoscopes were used in 65 pediatric cholesteatoma cases in 38 primary ears (34 patients), followed for an average of 2...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28543040/automated-smartphone-audiometry-validation-of-a-word-recognition-test-app
#18
Nicholas A Dewyer, Patpong Jiradejvong, Jennifer Henderson Sabes, Charles J Limb
OBJECTIVES/HYPOTHESIS: Develop and validate an automated smartphone word recognition test. STUDY DESIGN: Cross-sectional case-control diagnostic test comparison. METHODS: An automated word recognition test was developed as an app for a smartphone with earphones. English-speaking adults with recent audiograms and various levels of hearing loss were recruited from an audiology clinic and were administered the smartphone word recognition test...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28542688/bilateral-hearing-and-vestibular-loss-in-a-patient-with-untreated-chronic-myeloid-leukemia
#19
Liyang Tang, Michael Schubert, Andrea Marlowe, Heather Weinreich
No abstract text is available yet for this article.
May 25, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28542633/new-chamber-stapes-prosthesis-a-preliminary-assessment-of-the-functioning-of-the-prototype
#20
Monika Kwacz, Magdalena Sołyga, Maciej Mrówka, Konrad Kamieniecki
Piston-stapedotomy is the most common method for hearing restoration in patients with otosclerosis. In this study, we have experimentally examined a prototype of a new chamber stapes prosthesis. The prototype was implanted in a human cadaver temporal bone. The round window vibrations before and after implantation were measured for the acoustic signal (90 dB SPL, 0.8-8 kHz) in the external auditory canal. In comparison with a 0.4-mm piston prosthesis, the chamber prosthesis induced significantly higher vibration of the round window, especially for frequencies above 1...
2017: PloS One
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