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https://www.readbyqxmd.com/read/29775273/the-role-of-clpp-protease-in-bacterial-pathogenesis-and-human-diseases
#1
Vaibhav Bhandari, Keith S Wong, Jin Lin Zhou, Mark F Mabanglo, Robert A Batey, Walid A Houry
In prokaryotic cells and eukaryotic organelles, the ClpP protease plays an important role in proteostasis. The disruption of ClpP function has been shown to influence the infectivity and virulence of a number of bacterial pathogens. More recently, ClpP has been found to be involved in various forms of carcinomas and in Perrault syndrome, which is an inherited condition characterized by hearing loss in males and females and by ovarian abnormalities in females. Hence, targeting ClpP is a potentially viable, attractive option for the treatment of different ailments...
May 18, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29775147/intraoperative-cochlear-nerve-mapping-with-the-mobile-cochlear-nerve-compound-action-potential-tracer-in-vestibular-schwannoma-surgery
#2
Nobuyuki Watanabe, Takuya Ishii, Kazuhiko Fujitsu, Shogo Kaku, Teruo Ichikawa, Kosuke Miyahara, Tomu Okada, Shin Tanino, Yasuhiro Uriu, Yuichi Murayama
OBJECTIVE The authors describe the usefulness and limitations of the cochlear nerve compound action potential (CNAP) mobile tracer (MCT) that they developed to aid in cochlear nerve mapping during vestibular schwannoma surgery (VSS) for hearing preservation. METHODS This MCT device requires no more than 2 seconds for stable placement on the nerve to obtain the CNAP and thus is able to trace the cochlear nerve instantaneously. Simultaneous bipolar and monopolar recording is possible. The authors present the outcomes of 18 consecutive patients who underwent preoperative useful hearing (defined as class I or II of the Gardner-Robertson classification system) and underwent hearing-preservation VSS with the use of the MCT...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29775031/-neurofeedback-therapy-in-the-treatment-of-tinnitus
#3
REVIEW
Z Q Zhao, G X Lei, Y L Li, D Zhang, W D Shen, S M Yang, Y H Qiao
Neurofeedback therapy is a fast-growing field of tinnitus treatment, which is a new type of biofeedback therapy. In the past, the "muscle tone" and "blood flow" were used as feedback signals in biofeedback therapy to treat tinnitus, however there was no long-term follow-up report. Instead, neurofeedback therapy utilizes EEG (electroencephalogram) as the feedback signal, which is also called EEG biofeedback therapy. At present, most treatments of tinnitus only record subjective measures of patients as evaluation indicators, whereas neurofeedback therapy is more convincing for using comprehensive evaluation including changes of brain wave as objective indicators and subjective measures of patients...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775024/-sleep-quality-analysis-in-patients-with-unilateral-idiopathic-sudden-sensorineural-hearing-loss
#4
Y J Wang, M M Wang, Z Q Hou, Z M Fang, H B Wang
Objective: To analyze the characteristics of sleep quality and its correlation with the clinical features and hearing curative effects in patients with unilateral idiopathic sudden sensorineural hearing loss (ISSHL). Method: Pittsburgh sleep quality index (PSQI) was applied to evaluate the sleep quality of unilateral ISSHL patients in our department. Patient group is divided into poor sleep quality subgroup (total PSQI score>7 points) and normal sleep subgroup (total PSQI score≤7 points). The differences of Patient group and two subgroups between hearing curative effect in the 30 days after treatment and sleep quality scores were compared and analyzed...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775022/-establishment-of-the-characterization-of-an-adult-digits-in-noise-test-based-on-internet
#5
B E Qi, T B Zhang, X X Fu, G P Li
Objective: The aim of this study is to explore the sensitivity and specificity of the internet-based digital noise threshold (DIN) test for detecting noise-induced hearing loss, expecting to provide a rapid and effective screening tool for clinical application. Method: This study enrolled 50 adult subjects, of which 34 were normal hearing (NH), 16 patients with sensorineural hearing loss (SNHL). Pure-tone audiometry, acoustic immittance and DIN test were tested respectively. Pearson's correlation coefficient was used to analyze the correlation between NH and SNHL...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775021/-the-correlation-between-radiological-classification-and-clinical-audiometry-in-otosclerosis
#6
Y Ren, K Wang, J Q Zhang
Objective: The aim of this study is to explore the correlation between radiological classification on HRCT and effects on surgery with hearing improvement in otosclerosis. Method: Thirty three patients (66 ears) with otosclerosis were enrolled to this study, who would be done operation using Fischs stapes surgery technique. All patients were classified according to axial HRCT preoperatively. All patients were evaluated by pure tone test preoperatively and 6 months postoperatively. Correlation between radiological classification and hearing effects were studied...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775006/-comparison-of-effects-for-acute-low-tone-sensorineural-hearing-loss-use-of-glucocorticoids-or-not
#7
C H Zhang
No abstract text is available yet for this article.
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29773983/somatosensory-cross-modal-reorganization-in-adults-with-age-related-early-stage-hearing-loss
#8
Garrett Cardon, Anu Sharma
Under conditions of profound sensory deprivation, the brain has the propensity to reorganize. For example, intact sensory modalities often recruit deficient modalities' cortices for neural processing. This process is known as cross-modal reorganization and has been shown in congenitally and profoundly deaf patients. However, much less is known about cross-modal cortical reorganization in persons with less severe cases of age-related hearing loss (ARHL), even though such cases are far more common. Thus, we investigated cross-modal reorganization between the auditory and somatosensory modalities in older adults with normal hearing (NH) and mild-moderate ARHL in response to vibrotactile stimulation using high density electroencephalography (EEG)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29773946/utility-of-the-care-dependency-scale-in-predicting-care-needs-and-health-risks-of-elderly-patients-admitted-to-a-geriatric-unit-a-cross-sectional-study-of-200-consecutive-patients
#9
Halina Doroszkiewicz, Matylda Sierakowska, Marta Muszalik
Objective: The aim of the study was to evaluate the usefulness of the Polish version of the Care Dependency Scale (CDS) in predicting care needs and health risks of elderly patients admitted to a geriatric unit. Methods: This was a cross-sectional study of 200 geriatric patients aged ≥60 years, chronologically admitted to a geriatrics unit in Poland. The study was carried out using the Polish version of the CDS questionnaire to evaluate biopsychosocial needs and the level of care dependency...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29773520/frequency-of-gjb2-mutations-in-patients-with-nonsyndromic-hearing-loss-from-an-ethnically-characterized-brazilian-population
#10
Felippe Felix, Marcia Gonçalves Ribeiro, Shiro Tomita, Mariano Gustavo Zalis
INTRODUCTION: In different parts of the world, mutations in the GJB2 gene are associated with nonsyndromic hearing loss, and the homozygous 35delG mutation (p.Gly12Valfs*2) is a major cause of hereditary hearing loss. However, the 35delG mutation is not equally prevalent across ethnicities, making it important to study other mutations, especially in multiethnic countries such as Brazil. OBJECTIVE: This study aimed to identify different mutations in the GJB2 gene in patients with severe to profound nonsyndromic sensorineural hearing loss of putative genetic origin, and who were negative or heterozygote for the 35delG mutation...
November 21, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29773417/stapes-surgery-preserving-the-superstructure-of-stapes-takagi-s-stapedotomy-in-otosclerosis-a-retrospective-study-of-24-consecutive-cases
#11
Shin-Ichi Sato, Akira Takagi, Takashi Fujiwara
OBJECTIVE: The aim of this study was to evaluate the hearing outcomes and complications of stapedotomy in which the stapes superstructure was preserved (Takagi's stapedotomy). In this surgical approach, the lenticular process of the incus rather is removed, than the superstructure of the stapes. METHODS: A single-center retrospective observational study was performed. We included all patients having Takagi's stapedotomy for otosclerosis between January 2005 and April 2016...
May 14, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29773124/otolaryngology-and-the-global-burden-of-disease
#12
REVIEW
James E Saunders, Zane Rankin, Kathryn Y Noonan
The Global Burden of Disease (GBD) project provides longitudinal analysis of the global burden of otolaryngologic diseases by measuring the all-cause mortality, years of life lost, the years of life lived with disability, and disability-adjusted life years. Hearing loss burden is assessed overall and as sequelae of other diseases, such as otitis media or meningitis. Using these measures, we can appreciate the high prevalence and disability related to hearing loss globally. Other otolaryngologic diseases that contribute to the GBD include otitis media, cleft lip and palate, head and neck cancer, facial trauma, and oral disorders...
June 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29772954/electric-acoustic-stimulation-suppresses-tinnitus-in-a-subject-with-high-frequency-single-sided-deafness
#13
Griet Mertens, Vincent Van Rompaey, Paul Van de Heyning
BACKGROUND: A suggested solution to suppress tinnitus is to restore the normal sensory input. This is based on the auditory deprivation hypothesis. It is known that hearing aids can provide sufficient activation of the auditory nervous system and reduce tinnitus in subjects with mild to moderate hearing loss and that cochlear implantation can reduce tinnitus in subjects with severe to profound hearing loss. This applies to subjects with single-sided deafness (SSD) or bilateral hearing loss...
May 17, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29772756/developing-an-acoustic-sensing-yarn-for-health-surveillance-in-a-military-setting
#14
Theodore Hughes-Riley, Tilak Dias
Overexposure to high levels of noise can cause permanent hearing disorders, which have a significant adverse effect on the quality of life of those affected. Injury due to noise can affect people in a variety of careers including construction workers, factory workers, and members of the armed forces. By monitoring the noise exposure of workers, overexposure can be avoided and suitable protective equipment can be provided. This work focused on the creation of a noise dosimeter suitable for use by members of the armed forces, where a discrete dosimeter was integrated into a textile helmet cover...
May 17, 2018: Sensors
https://www.readbyqxmd.com/read/29771904/development-of-an-otitis-media-strategy-in-the-pacific-key-informant-perspectives
#15
Elizabeth Holt, Judith McCool, Vili Nosa, Peter Thorne
AIM: Ear and hearing health services are scarce within Pacific Island countries. Where available, they remain under-resourced, despite there being a high estimated prevalence of otitis media and otitis media-related hearing loss. This study examines the potential for improving ear and hearing health strategies by examining key factors, opportunities and challenges, working with Fiji as a case study. METHOD: A series of semi-structured interviews were conducted with professionals who had experience in otitis media programme implementation and/or professionals with working experience within the Pacific region and the Fiji health system...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29771080/-analysis-of-related-factors-of-coins-foreign-bodies-crossing-the-esophagus-in-204-cases-of-children
#16
M M Ni, L Liu, R Zhao, M Nie, X H Yang
Objective: To evaluate the effect of systemic and intratympanic dexamethasone combination therapy on sudden deafness. Method: A total of 98 patients randomly divided into three groups: an intravenous corticosteroid (systemic corticosteroid monotherapy group); an intratympanic corticosteroid (IT monotherapy group); and a combination therapy group (IT plus systemic combination group). All patients were treated additionally with ginkgo-damole and mecobalamine and proton pomp inhibitor. An audiometry was performed before and after the therapies in all patients...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771077/-observation-of-flupentixol-and-melitracen-on-curative-effect-of-sudden-deafness-patients-with-anxiety-and-depression-in-different-stages
#17
T Zhang, G D Yu
Objective: To investigate the efficacy of flupentixol melitracen on different stages of sudden deafness patients with anxiety and depression. Method: Totally one hundred and sixty-three sudden deafness patients with anxiety and depression were randomly divided into two groups: experimental group(81 cases) and control group (82 cases). All patients were given routine treatment for 2 weeks. The experimental group was given oral flupentixol melitracen (1 tablet/day)for a period of 3 months. The hearing, tinnitus effect and vertigo treatment course were observed and compared...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770645/atoh1-regulation-in-the-cochlea-more-than-just-transcription
#18
REVIEW
Yen-Fu Cheng
More than 80% of all cases of deafness are related to the death or degeneration of cochlear hair cells and the associated spiral ganglion neurons, and a lack of regeneration of these cells leads to permanent hearing loss. Therefore, the regeneration of lost hair cells is an important goal for the treatment of deafness. Atoh1 is a basic helix-loop-helix (bHLH) transcription factor that is critical in both the development and regeneration of cochlear hair cells. Atoh1 is transcriptionally regulated by several signaling pathways, including Notch and Wnt signalings...
July 13, 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29770223/profound-hearing-loss-following-surgery-in-pediatric-patients-with-posterior-fossa-low-grade-glioma
#19
Yahya Ghazwani, Ibrahim Qaddoumi, Johnnie K Bass, Shengjie Wu, Jason Chiang, Frederick Boop, Amar Gajjar, Zsila Sadighi
Background: Hearing loss may occur in patients with posterior fossa low-grade glioma who undergo surgery. Methods: We retrospectively reviewed 217 patients with posterior fossa low-grade glioma, including 115 for whom results of hearing tests performed after surgery and before chemotherapy or radiation therapy were available. We explored the association of UHL with age at diagnosis, sex, race, tumor location, extent of resection, posterior fossa syndrome, ventriculoperitoneal shunt placement, and histology...
May 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29770122/acute-unilateral-audiovestibulopathy-due-to-embolic-labyrinthine-infarction
#20
Zhong Liqun, Kee-Hong Park, Hyo-Jung Kim, Sun-Uk Lee, Jeong-Yoon Choi, Ji-Soo Kim
Introduction: Labyrinthine infarction is a cause of acute audiovestibulopathy, but can be diagnosed only in association with other infarctions involving the brainstem or cerebellar areas supplied by the anterior inferior cerebellar artery (AICA) since current imaging techniques cannot visualize an infarction confined to the labyrinth. This case series aimed to establish embolic labyrinthine infarction as a mechanism of isolated acute audiovestibulopathy. Methods: We analyzed clinical features, imaging findings, and mechanisms of embolism in 10 patients (8 men, age range: 38-76) who had developed acute audiovestibulopathy in association with an obvious source of embolism and concurrent acute embolic infarctions in the non-anterior inferior cerebellar artery territories...
2018: Frontiers in Neurology
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