keyword
https://read.qxmd.com/read/38520329/transition-metal-ru-ii-catalysts-immobilized-nanoreactors-for-conditional-bioorthogonal-catalysis-in-cells
#1
JOURNAL ARTICLE
Zhiguo Gao, Yaojia Li, Jiaqi Xing, Yougong Lu, Quanlin Shao, Jinzhong Hu, Shan Zhao, Wei He, Baiwang Sun
Employing transition metal catalysts (TMCs) to perform bioorthogonal activation of prodrugs and pro-fluorophores in biological systems, particularly in a conditional fashion, remains a challenge. Here, we used a mesoporous organosilica nanoscaffold (RuMSN), which localizes Ru(II) conjugates on the pore wall, enabling the biorthogonal photoreduction reactions of azide groups. Due to easily adjustable surface charges and pore diameter, this efficiently engineering RuMSN catalyst, with abundant active sites on the inner pore well, could spontaneously repel or attract substrates with different molecular sizes and charges and thus ensure selective bioorthogonal catalysis...
March 23, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38516621/live-cell-super-resolution-imaging-unconventional-dynamics-and-assemblies-of-nuclear-pore-complexes
#2
JOURNAL ARTICLE
Xianxin Ye, Minzhu Guan, Yaorong Guo, Xiang Liu, Kunhao Wang, Tongsheng Chen, Shiqun Zhao, Liangyi Chen
Super-resolution microscopy has promoted the development of cell biology, but imaging proteins with low copy numbers in cellular structures remains challenging. The limited number of designated proteins within nuclear pore complexes (NPCs) impedes continuous observation in live cells, although they are often used as a standard for evaluating various SR methods. To address this issue, we tagged POM121 with Halo-SiR and imaged it using structured illumination microscopy with sparse deconvolution (Sparse-SIM)...
August 31, 2023: Biophysics Reports
https://read.qxmd.com/read/38509107/structure-of-an-open-k-atp-channel-reveals-tandem-pip-2-binding-sites-mediating-the-kir6-2-and-sur1-regulatory-interface
#3
JOURNAL ARTICLE
Camden M Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng
ATP-sensitive potassium (KATP ) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells. KATP channel opening is stimulated by PIP2 and inhibited by ATP. Mutations that increase channel opening by PIP2 reduce ATP inhibition and cause neonatal diabetes. Although considerable evidence has implicated a role for PIP2 in KATP channel function, previously solved open-channel structures have lacked bound PIP2 , and mechanisms by which PIP2 regulates KATP channels remain unresolved...
March 20, 2024: Nature Communications
https://read.qxmd.com/read/38503703/-determination-of-four-phenolic-endocrine-disrupting-chemicals-in-water-by-dispersive-solid-phase-extraction-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-based-on-metal-organic-skeleton-porous-carbon-materials
#4
JOURNAL ARTICLE
Pan Wang, Ji-Ping Ma, Shuang Li, Jia-Wen Cheng, Chao-Nan Huang
Phenolic endocrine-disrupting chemicals (EDCs) are exogenous substances that interfere with the endocrine system and disrupt normal cell functions upon entering a living organism, leading to reproductive and developmental toxicity. Therefore, the development of a rapid and efficient analytical method for detecting phenolic EDCs in environmental waters is crucial. Owing to the low concentration of phenolic EDCs in environmental water, appropriate sample pretreatment methods are necessary to remove interferences caused by the sample matrix and enrich the target analytes before instrumental analysis...
March 8, 2024: Se Pu, Chinese Journal of Chromatography
https://read.qxmd.com/read/38480247/two-new-species-of-monopisthocotyla-dactylogyridea-dactylogyridae-parasitizing-the-nasal-cavities-of-bryconops-melanurus-characiformes-iguanodectidae-from-coastal-drainages-of-the-eastern-amazon-brazil
#5
JOURNAL ARTICLE
Joo F Santos-Neto, Saymon M Paixo, Marcus V Domingues
The present study integrates molecular and morphological data to support the proposal of new species of Telethecium Kritsky, Van Every & Boeger, 1996 and Diaphorocleidus Jogunoori, Kritsky & Venkatanarasaiah, 2004 from the nasal cavities of Bryconops melanurus (Bloch) of the coastal drainages of the Eastern Amazon. Telethecium tiquira sp. n. is characterized by possessing a male copulatory organ (MCO) with two circular sclerotized brims on the base, a coiled tubular shaft having 1 counterclockwise rings, an accessory piece with enlarged base, pincer-shaped at the distal portion; a sclerotized calyx-shaped vaginal vestibule, and hooks with proximal shank dilatation comprising 3/4 of the shank length...
February 13, 2024: Zootaxa
https://read.qxmd.com/read/38436215/-not-available
#6
REVIEW
Ariadna Delgado-Bermúdez, Marc Yeste, Sergi Bonet, Elisabeth Pinart
BACKGROUND: Ion channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage-gated channels (Kv), ligand-gated channels (Kligand ), inwardly rectifying channels (Kir ), and tandem pore domain channels (K2P ). MATERIAL-METHODS: The present review includes recent findings on the role of potassium channels in sperm physiology of mammals...
March 4, 2024: Andrology
https://read.qxmd.com/read/38354505/considering-the-selectivity-of-pore-size-gradient-size-exclusion-chromatography-columns
#7
JOURNAL ARTICLE
Szabolcs Fekete, Matthew Lauber, Mingcheng Xu
One of the most significant performance determining variables of a size exclusion column is the pore size of its packing material. This is most definitely the case for assigning the suitability of a given column for differently sized analytes. As technologies for particle and column manufacturing continue to advance, it is worth contemplating the value of more finely controlled manipulation of this parameter. The change in a packing material's pores across the length of a size exclusion column was thus explored...
February 8, 2024: Journal of Chromatography. A
https://read.qxmd.com/read/38351772/tandem-templating-strategies-facilitate-the-assembly-of-calix-8-arene-supported-ln-18-clusters
#8
JOURNAL ARTICLE
Yushu Jiao, Sergio Sanz, Jan van Leusen, David Gracia, Angelos B Canaj, Marco Evangelisti, Euan K Brechin, Scott J Dalgarno, Paul Kögerler
Calix[ n ]arenes offer ideal chemical functionality through the polyphenolic lower rim to construct nano-sized coordination clusters with lanthanide (Ln) metal ions ( e.g. , NdIII10, GdIII8). However, the number of metal centers they can accommodate is still limited compared to that achievable with smaller ligands ( e.g. , GdIII140, GdIII104). Here, we exploit a combination of the "anion template strategy" and "templating ligands" to synthesise three highly symmetric ( D 3h , trigonal planar) LnIII18 (Ln = La, Nd, and Gd) systems, representing the largest calix[ n ]arene-based coordination clusters yet...
February 14, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38335958/structures-and-ion-transport-mechanisms-of-plant-high-affinity-potassium-transporters
#9
JOURNAL ARTICLE
Jiangqin Wang, Yanping Luo, Fan Ye, Zhong Jie Ding, Shao Jian Zheng, Shuai Qiao, Yong Wang, Jiangtao Guo, Wei Yang, Nannan Su
Plant high-affinity K+ transporters (HKTs) mediate Na+ and K+ uptake, maintain Na+ /K+ homeostasis, and therefore play crucial roles in plant salt tolerance. In this study, we present cryoelectron microscopy structures of HKTs from two classes, class I HKT1;1 from Arabidopsis thaliana (AtHKT1;1) and class II HKT2;1 from Triticum aestivum (TaHKT2;1), in both Na+ - and K+ -bound states at 2.6- to 3.0-Å resolutions. Both AtHKT1;1 and TaHKT2;1 function as homodimers. Each HKT subunit consists of four tandem domain units (D1-D4) with a repeated K+ -channel-like M-P-M topology...
February 7, 2024: Molecular Plant
https://read.qxmd.com/read/38303137/a-hierarchical-metal-organic-framework-composite-aerogel-catalyst-containing-integrated-acid-base-and-metal-sites-for-the-one-pot-catalytic-synthesis-of-cyclic-carbonates
#10
JOURNAL ARTICLE
Xinyu Zhao, Ganggang Chang, Hongjian Xu, Yao Yao, Didi Dong, Shujie Yang, Ge Tian, Xiaoyu Yang
Catalysis has played a decisive role in the development of unique chemical reactions to produce important chemicals. However, conventional stepwise synthetic routes that rely on individual catalysts to promote each step often suffer from ponderous processes for the isolation of intermediates that result in massive material losses and large economic expenditures. In addition, traditional powder forms of these catalysts suffer from poor processability and recoverability. Herein, we designed and prepared a hierarchical metal-organic framework (MOF) composite monolithic catalyst IL-Au@UiO-66-NH2 /CMC that contains integrated acid (Zr4+ ), base (ionic liquid (IL)), and metal sites (Au nanoparticles (NPs)) to promote the one-pot preparation of cyclic carbonates from styrene derivatives and CO2 ...
February 1, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38233203/deep-cracking-of-bulky-hydrocarbons-into-light-products-via-tandem-catalysis-over-uniform-interconnected-zsm-5-alsba-15-composites
#11
JOURNAL ARTICLE
Yali Zhang, Jiaren Wang, Xianglin Xie, Xiaoning Wang, Winston Duo Wu, Xiao Dong Chen, Zhangxiong Wu
Deep cracking of bulky hydrocarbons on zeolite-containing catalysts into light products with high activity, desired selectivity, and long-term stability is demanded but challenging. Herein, the efficient deep cracking of 1,3,5-triisopropylbenzene (TIPB) on intimate ZSM-5@AlSBA-15 composites via tandem catalysis is demonstrated. The rapid aerosol-confined assembly enables the synthesis of the composites composed of a continuous AlSBA-15 matrix decorated with isolated ZSM-5 nanoparticles. The two components at various ZSM-5/AlSBA-15 mass ratios are uniformly mixed with chemically bonded pore walls, interconnected pores, and eliminated external surfaces of nanosized ZSM-5...
January 17, 2024: Small
https://read.qxmd.com/read/38177114/nuclear-pore-protein-pom121-regulates-subcellular-localization-and-transcriptional-activity-of-ppar%C3%AE
#12
JOURNAL ARTICLE
Yanxiong Yu, Mohammad S Farooq, Sabine Eberhart Meessen, Yidan Jiang, Dominik Kato, Tianzuo Zhan, Christel Weiss, Rony Seger, Wei Kang, Xiang Zhang, Jun Yu, Matthias P A Ebert, Elke Burgermeister
Manipulation of the subcellular localization of transcription factors by preventing their shuttling via the nuclear pore complex (NPC) emerges as a novel therapeutic strategy against cancer. One transmembrane component of the NPC is POM121, encoded by a tandem gene locus POM121A/C on chromosome 7. Overexpression of POM121 is associated with metabolic diseases (e.g., diabetes) and unfavorable clinical outcome in patients with colorectal cancer (CRC). Peroxisome proliferator-activated receptor-gamma (PPARγ) is a transcription factor with anti-diabetic and anti-tumoral efficacy...
January 4, 2024: Cell Death & Disease
https://read.qxmd.com/read/38141489/nano-plastics-and-gastric-health-decoding-the-cytotoxic-mechanisms-of-polystyrene-nano-plastics-size
#13
JOURNAL ARTICLE
Mingming Han, Tian Zhu, Ji Liang, Hong Wang, Chenxi Zhu, Anisah Lee Binti Abdullah, James Rubinstein, Richard Worthington, Andrew George, Yiming Li, Wei Qin, Qichen Jiang
Gastrointestinal diseases exert a profound impact on global health, leading to millions of healthcare interventions and a significant number of fatalities annually. This, coupled with escalating healthcare expenditures, underscores the need for identifying and addressing potential exacerbating factors. One emerging concern is the pervasive presence of microplastics and nano-plastics in the environment, largely attributed to the indiscriminate usage of disposable plastic items. These nano-plastics, having infiltrated our food chain, pose a potential threat to gastrointestinal health...
December 11, 2023: Environment International
https://read.qxmd.com/read/38113885/protein-semisynthesis-underscores-the-role-of-a-conserved-lysine-in-activation-and-desensitization-of-acid-sensing-ion-channels
#14
JOURNAL ARTICLE
Debayan Sarkar, Iacopo Galleano, Stephanie Andrea Heusser, Sofie Yuewei Ou, Gül Refika Uzun, Keith K Khoo, Gerbrand Jan van der Heden van Noort, Joseph Scott Harrison, Stephan Alexander Pless
Acid-sensing ion channels (ASICs) are trimeric ion channels that open a cation-conducting pore in response to proton binding. Excessive ASIC activation during prolonged acidosis in conditions such as inflammation and ischemia is linked to pain and stroke. A conserved lysine in the extracellular domain (Lys211 in mASIC1a) is suggested to play a key role in ASIC function. However, the precise contributions are difficult to dissect with conventional mutagenesis, as replacement of Lys211 with naturally occurring amino acids invariably changes multiple physico-chemical parameters...
December 14, 2023: Cell Chemical Biology
https://read.qxmd.com/read/38071772/functionalized-magnetic-metal-organic-framework-nanocomposites-for-high-throughput-automation-extraction-and-sensitive-detection-of-antipsychotic-drugs-in-serum-samples
#15
JOURNAL ARTICLE
Zelin Zhang, Wei Han, Jiang Qing, Taoyu Meng, Wenli Zhou, Zhou Xu, Maolong Chen, Li Wen, Yunhui Cheng, Li Ding
Due to the complexity of biological sample matrix, the automated and high-throughput pretreatment technology is urgently needed for monitoring the antipsychotic drugs for mental patients. In this study, functionalized magnetic zirconium-based organic framework nanocomposites (Fe3 O4 @SiO2 @Zr-MOFs) were successfully designed and synthesized by the layer-by-layer growth. Among them, Fe3 O4 @SiO2 @UiO-67-COOH showed the best adsorption performance, and at the same time it exhibited excellent water dispersibility, high thermal stability, chemical stability and high hydrophobicity...
December 6, 2023: Journal of Hazardous Materials
https://read.qxmd.com/read/38048683/mechanochemical-synthesis-ionic-covalent-organic-frameworks-cotton-composites-for-pipette-tip-solid-phase-extraction-of-domoic-acid-in-seafood
#16
JOURNAL ARTICLE
Zhiyong Wang, Shiye Xie, Wenmin Zhang, Hui Chen, Qingqing Ding, Jinhua Xu, Qidong Yu, Lan Zhang
Pipette tip solid-phase extraction (PT-SPE) as a miniaturized solid-phase extraction technique have a wide range of applications in the field of sample pretreatment. In this study, ionic covalent organic frameworks@cotton (iCOF@cotton) were facilely synthesized by mechanochemical grinding method only in half an hour, and used as the adsorbents of PT-SPE. The synthesized iCOF@cotton not only had high specific surface area, suitable pore structure and cationic charge groups of iCOF that can extract polar targets quickly, but also reduced the problem of high back pressure of PT-SPE by the addition of cotton, thus accelerating extraction time...
November 28, 2023: Talanta
https://read.qxmd.com/read/38029290/facile-hydrogenolysis-of-sugars-to-1-2-glycols-by-ru-pph-3-opph-3-confined-large-pore-mesoporous-silica
#17
JOURNAL ARTICLE
Arindam Modak, Deepika Gill, Komal Sharma, Vidha Bhasin, Kamal K Pant, S N Jha, Dibyendu Bhattacharyya, Saswata Bhattacharya
Tandem hydrogenation vis-à-vis hydrogenolysis of xylose to 1,2-glycols remains a major challenge. Although one-pot conversion of xylose to 1,2-glycols requires stringent conditions, a sustainable approach would be quite noteworthy. We have developed a microwave route for the one-pot conversion of pentose (C5) and hexose (C6) sugars into glycol and hexitol, without pressurized hydrogen reactors. A pronounced hydrogenolysis of sugars to glycols is observed by Ru single atom (SA) on triphenylphosphine/phosphine oxide-modified silica (Ru@SiP), in contrast to Ru SA on pristine (Ru@SiC) and 3-aminopropyl-modified silica (Ru@SiN)...
November 29, 2023: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38000282/green-construction-of-magnetic-azo-porous-organic-polymer-for-highly-efficient-enrichment-and-detection-of-phenolic-endocrine-disruptors
#18
JOURNAL ARTICLE
Chenhuan Wang, Bin Zhao, Qianqian Wang, Shuaihua Zhang, Qiuhua Wu, Xiaodong Shi
Porous organic polymers (POPs) are prominent sorbents for effective extraction of endocrine disrupting chemicals (EDCs). However, green and sustainable construction of functional POPs is still challenging. Herein, we developed a magnetic azo POP (Mazo-POP) for the first time using hydroxy-rich natural kaempferol and low-toxic basic fuchsin as monomers through a diazo coupling reaction. The Mazo-POP exhibited excellent extraction capabilities for EDCs with a phenolic structure. Consequently, it was used as a magnetic sorbent for extracting phenolic EDCs from water and fish samples, followed by ultrahigh-performance liquid chromatography-tandem mass spectrometric detection...
November 21, 2023: Journal of Hazardous Materials
https://read.qxmd.com/read/37995550/bimetallic-metal-organic-framework-as-an-efficient-sorbent-for-the-extraction-of-tacrolimus-and-cyclosporine-from-plasma-before-hplc-ms-ms-analysis
#19
JOURNAL ARTICLE
Farhad Mehrvarz, Gholamreza Dehghan, Mohammad Reza Afshar Mogaddam
This study investigated the application of pores-size protocols into metal-organic frameworks that can lead to improved adsorption capacity of sorbents. A selective, fast, and sensitive analytical procedure based on dispersive solid phase extraction using a bimetallic metal organic framework named ZrZnMOF coupled with high-performance liquid chromatography-tandem mass spectrometry was established for the simultaneous quantification of tacrolimus and cyclosporine in plasma. The effects of several parameters, such as the dosage of sorbent, separation and elution times, volume and type of elution solvent, were investigated...
November 4, 2023: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/37985060/pd-hkust-1-cu-ii-cmc-composite-bead-as-an-efficient-synergistic-bimetallic-catalyst-for-sonogashira-cross-coupling-reactions
#20
JOURNAL ARTICLE
Yuling Huang, Jiayi Huang, Yuping Zhou, Xuetao Fan, Yiqun Li
We fabricated an efficient Pd@HKUST-1@Cu(II)/CMC composite bead catalyst through an innovative strategy based on the unique properties of metal-organic frameworks (MOFs) and carboxymethylcellulose (CMC). In this strategy, HKUST-1 MOFs were grown in-situ on the surface of micrometer-sized Cu-based CMC beads (Cu(II)/CMC), then Pd(II) ions were incorporated into the pores of the MOF and further be partially reduced to Pd(0) NPs, which is an active species for oxidative addition with aryl halides in Sonogashira reactions...
January 15, 2024: Carbohydrate Polymers
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