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https://www.readbyqxmd.com/read/29906625/computed-tomography-and-magnetic-resonance-imaging-findings-of-pancreatic-hamartoma-a-case-report-and-literature-review
#1
Yeo Eun Han, Beom Jin Park, Deuk Jae Sung, Min Ju Kim, Na Yeon Han, Ki Choon Sim, Sung Bum Cho, Joo Young Kim
Pancreatic hamartoma is a rare benign malformation that resembles a neoplasm and may be mistaken for a malignancy. The imaging findings of pancreatic hamartoma are not well established, as only one radiological case report has been described since 1983. Herein, we discussed a case of pancreatic hamartoma in a 35-year-old woman and conducted a literature review focused on imaging findings and differential diagnosis of pancreatic hamartoma. Increased late enhancement on post-contrast dynamic study and absence of diffusion restriction may be characteristic MR imaging findings of pancreatic hamartoma that may narrow the differential diagnosis of hypervascular pancreatic lesions...
June 6, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29904461/pancreatic-arteriovenous-malformation-mimicking-pancreatic-neoplasm-a-systematic-multimodality-diagnostic-approach-and-treatment
#2
Olga Nikolaidou, Ekaterini Xinou, Pavlos Papakotoulas, Andis Philippides, Dimitra Panagiotopoulou-Boukla
Pancreatic arteriovenous malformation (pAVM) is a very rare entity, as less than 100 cases are reported in the international literature. Patients with pAVM may be asymptomatic or may present a wide range of symptoms, such as vague pain, feeling of fullness, gastrointestinal bleeding, or even portal hypertension. We present the multimodality approach in the diagnosis of a patient with pAVM and treatment via transcatheter arterial embolization of the lesion using steel coils. The patient was free of symptoms 12 months later...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29903633/incidence-and-reasons-of-pancreatic-resection-in-patients-with-asymptomatic-serous-cystadenoma
#3
Carlo Lombardo, Sara Iacopi, Francesca Menonna, Niccolò Napoli, Emanuele Kauffmann, Juri Bernardini, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Carla Cappelli, Daniela Campani, Davide Caramella, Ugo Boggi
BACKGROUND/OBJECTIVES: Despite diagnostic refinements, pancreatic resection (PR) is eventually performed in some patients with asymptomatic serous cystadenoma (A-SCA). The aim of this study was to define incidence and reasons of PR in A-SCA. METHODS: A retrospective analysis of a prospectively maintained database was performed for all the patients referred for pancreatic cystic lesions (PCL) between January 2005 and March 2016. RESULTS: Overall, there were 1488 patients with PCL, including 1271 (85...
June 8, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29903049/the-hepatic-pre-metastatic-niche-in-pancreatic-ductal-adenocarcinoma
#4
REVIEW
Demi S Houg, Maarten F Bijlsma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies to date, largely because it is associated with high metastatic risk. Pancreatic tumors have a characteristic tendency to metastasize preferentially to the liver. Over the past two decades, it has become evident that the otherwise hostile milieu of the liver is selectively preconditioned at an early stage to render it more conducive to the engraftment and growth of disseminated cancer cells, a concept defined as pre-metastatic niche (PMN) formation...
June 14, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29900044/cd133-directed-car-t-cells-for-advanced-metastasis-malignancies-a-phase-i-trial
#5
Yao Wang, Meixia Chen, Zhiqiang Wu, Chuan Tong, Hanren Dai, Yelei Guo, Yang Liu, Jianhua Huang, Haiyan Lv, Can Luo, Kai-Chao Feng, Qing-Ming Yang, Xiao-Lei Li, Weidong Han
Expressed by cancer stem cells of various epithelial cell origins, CD133 is an attractive therapeutic target for cancers. Autologous chimeric antigen receptor-modified T-cell directed CD133 (CART-133) was first tested in this trial. The anti-tumor specificity and the postulated toxicities of CART-133 were first assessed. Then, we conducted a phase I clinical study in which patients with advanced and CD133-positive tumors received CART-133 cell-infusion. We enrolled 23 patients (14 with hepatocellular carcinoma [HCC], 7 with pancreatic carcinomas, and 2 with colorectal carcinomas)...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29899870/biomarkers-for-the-risk-of-thrombosis-in-pancreatic-adenocarcinoma-are-related-to-cancer-process
#6
Dorothée Faille, Marie-Charlotte Bourrienne, Emmanuelle de Raucourt, Luc de Chaisemartin, Vanessa Granger, Romaric Lacroix, Laurence Panicot-Dubois, Pascal Hammel, Philippe Lévy, Philippe Ruszniewski, Nadine Ajzenberg, Vinciane Rebours
Background: Venous thrombo-embolic events (VTE) frequently occur in patients with pancreatic ductal adenocarcinoma (PDAC) and contribute to high morbidity and mortality. Objectives: To determine whether VTE biomarkers are related to cancer, inflammation or precancerous states and to assess their relevance to predict VTE in PDAC. Patients and Methods: We compared VTE biomarkers in patients with PDAC ( n = 42), intraductal papillary mucinous neoplasm of the pancreas (IPMN, n = 48) or chronic pancreatitis ( n = 50)...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29899320/pancreatic-cystic-lesions-pathogenesis-and-malignant-potential
#7
REVIEW
Antoinette J Pusateri, Somashekar G Krishna
Pancreatic cancer remains one of the most lethal cancers despite extensive research. Further understanding of precursor lesions may enhance the ability to treat and prevent pancreatic cancer. Pancreatic cystic lesions (PCLs) with malignant potential include: mucinous PCLs (intraductal papillary mucinous neoplasms and mucinous cystic neoplasm), solid pseudopapillary tumors and cystic neuroendocrine tumors. This review summarizes the latest literature describing what is known about the pathogenesis and malignant potential of these PCLs, including unique epidemiological, radiological, histological, genetic and molecular characteristics...
June 13, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29898439/the-diagnostic-accuracy-of-cytology-for-the-diagnosis-of-hepatobiliary-and-pancreatic-cancers
#8
Marwan Al-Hajeili, Maryam Alqassas, Astabraq Alomran, Bashaer Batarfi, Bashaer Basunaid, Reem Alshail, Shahad Alaydarous, Rana Bokhary, Mahmoud Mosli
OBJECTIVE: Although cytology testing is considered a valuable method to diagnose tumors that are difficult to access such as hepato-biliary-pancreatic (HBP) malignancies, its diagnostic accuracy remains unclear. We therefore aimed to investigate the diagnostic accuracy of cytology testing for HBP tumors. STUDY DESIGN: We performed a retrospective study of all cytology samples that were used to confirm radiologically detected HBP tumors between 2002 and 2016. The cytology techniques used in our center included fine needle aspiration (FNA), brush cytology, and aspiration of bile...
June 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29896581/a-long-term-survival-case-of-advanced-biliary-cancer-with-repeated-resection-due-to-recurrence-in-the-pancreaticogastrostomy-site-after-pancreaticoduodenectomy
#9
Shohei Eto, Masashi Ishikawa, Michihito Asanoma, Yoshihiko Tashiro, Kazuo Matsuyama, Takehito Oshio
A 62-year-old man underwent endoscopic mucosal resection for early gastric cancer. The follow-up computed tomography revealed biliary dilatation. The tumor was located in the lower bile duct with biliary dilatation, and no evidence of metastasis in other organs was noted. The patient underwent subtotal stomach-preserving pancreatoduodenectomy with pancreaticogastrostomy and Billroth I anastomosis. At 13 months after the operation, gastrointestinal endoscopy revealed a tumor lesion in the pancreaticogastrostomy site...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29895293/robotic-treatment-of-oligometastatic-kidney-tumor-with-synchronous-pancreatic-metastasis-case-report-and-review-of-the-literature
#10
Andrea Boni, Giovanni Cochetti, Stefano Ascani, Michele Del Zingaro, Francesca Quadrini, Alessio Paladini, Diego Cocca, Ettore Mearini
BACKGROUND: The management of metastatic Renal Cell Carcinoma (RCC) has changed dramatically in the last 20 years, and the role of surgery in the immunotherapy's era is under debate. Metastatic lesions interesting pancreas are infrequent, but those harbouring from RCC have an high incidence. If metachronous resections are not rare, synchronous resection of primary RCC and its pancreatic metastasis is uncommonly reported, and accounts for a bad prognosis. CASE PRESENTATION: We report the case of a 68 years old woman, who presented hematuria at hospital incoming, with radiological appearance of a 13 cm left renal mass, with a 2...
June 13, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29895201/neat-en-ing-up-our-understanding-of-p53-pathways-in-tumor-suppression
#11
Stephano Spano Mello, Laura Donatella Attardi
Although the p53 transcription factor has a well-established role in tumor suppression, little is known about how the non-coding targets of p53 mediate its tumor suppression function. Analysis of ncRNAs regulated by p53 revealed Neat1 as a direct p53 target gene. Neat1 has physiological roles in the development and differentiation of the mammary gland and corpus luteum, but its roles in cancer have been conflicting. To unequivocally understand Neat1 function in cancer, we used Neat1 null mice. Interestingly, we found that Neat1 deficiency promotes transformation both in oncogene-expressing fibroblasts and in a mouse model for pancreatic cancer...
June 12, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29893579/eus-fna-cytological-material-from-pancreatic-lesions-the-expression-of-cathepsins-and-its-predictive-value-of-malignancy
#12
Manuela Roger, Juan Martínez, Gloria Peiró, Jose Ramón Aparicio, Francisco Ruiz, Luís Compañy, Juan Antonio Casellas
AIMS: To assess the expression of cathepsins in pancreatic samples obtained by endoscopic ultrasonography and fine needle aspiration (EUS-FNA) and to investigate their relationship with the staging of the pancreatic ductal adenocarcinoma (PDAC). METHODS: We prospectively included patients with solid pancreatic masses, in which EUS-FNA were performed. Cathepsins B, L, S and H expression was determined in FNA samples. RESULTS: Seventeen FNA were performed...
June 12, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29890488/pancreatobiliary-fistula-associated-with-intraductal-papillary-mucinous-carcinoma-accompanying-obstructive-jaundice-a-case-report
#13
Toshiaki Komo, Koichi Oishi, Toshihiko Kohashi, Jun Hihara, Mikihiro Kanou, Akira Nakashima, Mayumi Kaneko, Hidenori Mukaida, Naoki Hirabayashi
INTRODUCTION: Intraductal papillary mucinous neoplasms (IPMNs) occasionally involve formation of fistulas with other adjacent organs. Pancreatobiliary fistulas associated with IPMNs are rare, but affected patients often develop obstructive jaundice and cholangitis. PRESENTATION OF CASE: A 79-year-old man was referred to our hospital for evaluation of abnormal biliary enzymes. Contrast-enhanced computed tomography and endoscopic retrograde cholangiopancreatography demonstrated multiple cystic lesions with septa in the pancreatic head and fistulas between the cystic lesions and common bile duct...
June 4, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29887592/-diagnostic-utility-of-endoscopic-ultrasonography-elastography-and-contrast-enhanced-harmonic-endoscopic-ultrasonography-in-a-patient-with-type-2-autoimmune-pancreatitis
#14
Masataka Yokode, Hideyuki Shiomi, Ryosuke Itai, Sakae Mikami, Yukimasa Yamashita, Ryota Nakano, Takeshi Ezaki, Atsuhiro Masuda, Yoh Zen
A referring hospital diagnosed a 57-year-old man with a pancreatic head mass. The initial endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) was inconclusive because of the small sample size. Endoscopic ultrasonography elastography (EUS-EG) and contrast-enhanced harmonic endoscopic ultrasonography (CE-EUS), conducted at our institute, raised the possibility of mass-forming pancreatitis or autoimmune pancreatitis (AIP). A repeat EUS-FNA revealed inflammatory changes, including a neutrophilic duct injury suggestive of type 2 AIP...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29886564/managing-incidental-pancreatic-cysts
#15
REVIEW
Jennifer Phan, V Raman Muthusamy
PURPOSE OF REVIEW: The goal of this review is to critically analyze the current literature regarding the management of incidental pancreatic cysts. Given their increased rates of detection due to the frequent use of cross-sectional imaging, correctly identifying the subset of high risk lesions that are appropriate for surgical resection is critical. However, the existing consensus and societal guidelines discussed in this review lack high quality data to create evidence-based recommendations, making achieving this important aim challenging...
June 9, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29884547/the-incretin-hormone-gip-is-upregulated-in-patients-with-atherosclerosis-and-stabilizes-plaques-in-apoe-mice-by-blocking-monocyte-macrophage-activation
#16
Florian Kahles, Ana Liberman, Constantin Halim, Matthias Rau, Julia Möllmann, Robert Werner Mertens, Marcia Rückbeil, Irmgard Diepolder, Benedikt Walla, Sebastian Diebold, Mathias Burgmaier, Corinna Lebherz, Nikolaus Marx, Michael Lehrke
OBJECTIVE: The incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by the gut after food intake leading to pancreatic insulin secretion and glucose lowering. Beyond its role in glucose control, GLP-1 was found in mice and men to beneficially modulate the process of atherosclerosis, which has been linked to improved cardiovascular outcome of patients with diabetes at high cardiovascular risk treated with GLP-1 receptor agonists...
May 23, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29882285/diagnosis-of-paraganglioma-as-a-pancreatic-mass-a-case-report
#17
Elise Nguyen, Manando Nakasaki, Thomas K Lee, Di Lu
Paragangliomas are rare neoplasms that arise from the chromaffin cells of the autonomic nervous system. Although paragangliomas can occur anywhere paraganglia are present, they tend to occur in the head, neck, and retroperitoneum. Rarely, paragangliomas can occur in the peripancreatic area and present as a pancreatic mass, creating a diagnostic challenge for the clinician, radiologist, and pathologist. Here, we present a case of a 70-year-old woman with history of breast carcinoma who presented with chronic constipation, early satiety, and an abdominal mass...
June 7, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29882080/s-1-induced-discoid-lupus-erythematosus-like-lesions-and-long-term-complete-response-for-para-aortic-lymph-node-recurrence-of-pancreatic-ductal-adenocarcinoma-a-case-report
#18
Ryosuke Yamaga, Koji Tezuka, Shuichiro Sugawara, Toshihiro Watanabe, Ichiro Hirai, Tamio Suzuki, Wataru Kimura
BACKGROUND: Metastatic recurrence after resection of pancreatic cancer is considered to be an incurable disease, and discoid lupus erythematosus (DLE)-like lesions are known as a side effect of fluorouracil agents. We report a very rare case of metastatic recurrence of pancreatic cancer in a Japanese man with DLE-like lesions in which long-term complete response was achieved through S-1 monotherapy. CASE PRESENTATION: A 65-year-old man who had undergone distal pancreatectomy with splenectomy for pancreatic body cancer and had received adjuvant gemcitabine developed postoperative para-aortic lymph node recurrence 17 months after surgery...
June 7, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29881603/results-of-surveillance-in-individuals-at-high-risk-of-pancreatic-cancer-a-systematic-review-and-meta-analysis
#19
REVIEW
Marianna Signoretti, Marco J Bruno, Giulia Zerboni, Jan-Werner Poley, Gianfranco Delle Fave, Gabriele Capurso
Background: Data on surveillance for pancreatic ductal adenocarcinoma (PDAC) in high-risk individuals (HRIs) with "familial pancreatic cancer" (FPC) and specific syndromes are limited and heterogeneous. Objective: We conducted a systematic review and meta-analysis of PDAC surveillance studies in HRIs. Methods: Prevalence of solid/cystic pancreatic lesions and of lesions considered a successful target of surveillance (proven resectable PDAC and high-grade precursors) was pooled across studies...
May 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29879222/a-retrospective-pathology-study-of-two-neotropical-deer-species-1995-2015-brazil-marsh-deer-blastocerus-dichotomus-and-brown-brocket-deer-mazama-gouazoubira
#20
Pedro Enrique Navas-Suárez, Josué Díaz-Delgado, Eliana Reiko Matushima, Cintia Maria Fávero, Angélica Maria Sánchez Sarmiento, Carlos Sacristán, Ana Carolina Ewbank, Adriana Marques Joppert, Jose Mauricio Barbanti Duarte, Cinthya Dos Santos-Cirqueira, Bruno Cogliati, Leonardo Mesquita, Paulo César Maiorka, José Luiz Catão-Dias
This retrospective study describes the biological and epidemiological aspects, gross and microscopical findings, and most likely causes of death (CD) in two species of Neotropical deer in Brazil. The animals were collected between 1995 and 2015 and represented 75 marsh deer (MD) and 136 brown brocket deer (BBD). Summarized, pneumonia was diagnosed microscopically in 48 MD and 52 BBD; 76 deer suffered trauma, involving dog attack (14 BBD) and vehicle-collision (14 BBD). Pulmonary edema (50 MD; 55 BBD) and congestion (57 MD; 78 BBD) were the most common findings for both species...
2018: PloS One
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