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Adenomyosis and treatment

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https://www.readbyqxmd.com/read/28642638/laparoscopic-surgery-for-focal-adenomyosis
#1
Jae-Young Kwack, Yong-Soon Kwon
BACKGROUND AND OBJECTIVES: For conservative surgical treatment of focal uterine adenomyosis, laparoscopic adenomyomectomy has been increasingly performed, so that reassessment to determine the safety and efficacy of the laparoscopic surgical technique in a larger number of cases and reevaluation for reproducibility for laparoscopic adenomyomectomy is needed. We evaluate the clinical outcomes of laparoscopic adenomyomectomy with transient occlusion of uterine arteries (TOUA) for focal uterine adenomyosis performed by a single surgeon at a single institute...
April 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28605821/abnormal-uterine-bleeding
#2
Cristina Laguna Benetti-Pinto, Ana Carolina Japur de Sá Rosa-E-Silva, Daniela Angerame Yela, José Maria Soares Júnior
Abnormal uterine bleeding is a frequent condition in Gynecology. It may impact physical, emotional sexual and professional aspects of the lives of women, impairing their quality of life. In cases of acute and severe bleeding, women may need urgent treatment with volumetric replacement and prescription of hemostatic substances. In some specific cases with more intense and prolonged bleeding, surgical treatment may be necessary. The objective of this chapter is to describe the main evidence on the treatment of women with abnormal uterine bleeding, both acute and chronic...
June 12, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28599883/uterine-sparing-laparoscopic-resection-of-accessory-cavitated-uterine-masses
#3
Ann Peters, Noah B Rindos, Richard S Guido, Nicole M Donnellan
To demonstrate surgical techniques utilized during uterine-sparing laparoscopic resections of accessory cavitated uterine masses (ACUM) BACKGROUND: ACUM represent a rare uterine entity observed in premenopausal women suffering from dysmenorrhea and recurrent pelvic pain. The diagnosis is made when an isolated extra-cavitated uterine mass is resected from an otherwise normal appearing uterus with unremarkable endometrial lumen and adnexal structures. Pathologic confirmation requires an accessory cavity lined with endometrial epithelium (and corresponding glands and stroma) filled with chocolate-brown fluid...
June 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28586290/non-contraceptive-benefits-of-intrauterine-levonorgestrel-administration-why-not
#4
Lorenzo Sabbioni, Felice Petraglia, Stefano Luisi
Levonorgestrel intrauterine systems (LNG-IUS) represent a modern therapy for an array of preexisting gynecological conditions, though they were first marketed in Finland in 1990. However, there are countries in which their use is extremely limited by social and cultural factors. This manuscript describes the possible reasons for this misuse, taking in consideration the clinical noncontraceptive benefits of intrauterine levonorgestrel in routinary practice. Medical diseases in which LNG-IUS represent a treatment include abnormal uterine bleeding, iron-deficiency anemia, endometrial hyperplasia, uterine fibroids, adenomyosis, endometriosis, and coagulopathies...
June 6, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28556124/uterine-adenomyosis-and-infertility-review-of-reproductive-outcome-after-in%C3%A2-vitro-fertilization-and-surgery
#5
REVIEW
Margit Dueholm
This review includes an analysis of the clinical studies evaluating reproductive outcome and adenomyosis, and a review of studies on reproductive outcome and surgical treatment options for adenomyosis. Strict diagnostic criteria and classification of disease are needed for an image diagnosis of adenomyosis. Studies of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) populations and women with surgically treated deep endometriosis have suggested that adenomyosis has a negative impact on reproductive outcome, although there are substantial variations between studies...
June 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28547742/increased-annexin-a2-and-decreased-%C3%AE-catenin-in-adenomyosis-contribute-to-adenomyosis-associated-dysmenorrhea
#6
Li Xue Liu, Yin Ga Wu, Jian Zheng
OBJECTIVE: To investigate the expression of annexin A2 (ANXA2) and β-catenin in eutopic and ectopic endometrium, and their relationships with adenomyosis-associated dysmenorrhea. METHODS: From December 2013 to June 2014, ectopic endometrium (n=30) and eutopic endometrium (n=30) of adenomyosis were collected as experimental group, and endometrium (n=30) of uterine myoma as control group from the department of gynecology and obstetrics, the affiliated hospital of Inner Mongolia medical university...
May 26, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28540825/the-role-of-t1-perfusion-based-classification-in-predicting-the-outcome-of-magnetic-resonance-guided-high-intensity-focused-ultrasound-treatment-of-adenomyosis
#7
Bilgin Keserci, Nguyen Minh Duc
OBJECTIVE: To assess the relationship between magnetic resonance (MR) T1 perfusion-based classification and the outcome of MR-guided high intensity focused ultrasound treatment of adenomyosis, defined as nonperfused volume (NPV) ratio. METHODS: The adenomyosis of 31 women was classified into group A (time-signal intensity [SI] curve of adenomyosis lower than that of the myometrium) and group B (time-SI curve of adenomyosis equal to or higher than that of the myometrium) on the basis of time-SI curves on dynamic contrast enhanced (DCE) MR images acquired at screening...
May 19, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28516272/uterine-artery-embolization-for-symptomatic-adenomyosis-7-year-clinical-follow-up-using-ufs-qol-questionnaire
#8
Annefleur M de Bruijn, Marieke Smink, Wouter J K Hehenkamp, Robbert J Nijenhuis, Albert J Smeets, Focco Boekkooi, Paul J H M Reuwer, Willem J Van Rooij, Paul N M Lohle
PURPOSE: The purpose of this study was to assess clinical outcomes 7 years after uterine artery embolization (UAE) in the treatment of symptomatic adenomyosis. MATERIALS AND METHODS: In this prospective cohort study, one specialized hospital in the Netherlands recruited patients with symptomatic adenomyosis or adenomyosis in combination with fibroids for UAE. The 7-year post-intervention outcomes were health-related quality of life (HRQOL), symptom severity scores (SSS), satisfaction, menopause and re-interventions...
May 17, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28489790/ca125-modified-by-plt-and-nlr-improves-the-predictive-accuracy-of-adenomyosis-derived-pelvic-dense-adhesion
#9
Caixia Jiang, Chao Liu, Jing Guo, Li Chen, Ning Luo, Xiaoyan Qu, Weihong Yang, Qing Ren, Zhongping Cheng
To explore the value of serum levels of CA125, platelet count (PLT), neutrophil-lymphocyte ratio (NLR), and modified CA125 markers CA125a and CA125b in predicting pelvic dense adhesion (PDA) associated with adenomyosis, CA125a = lg(CA125 × PLT × 10), CA125b = lg(CA125 × NLR).This retrospective study included 304 patients who underwent surgery for adenomyosis. Correlations of serum levels of CA125, PLT, NLR, and modified CA125 markers with adenomyosis-derived PDA were analyzed by Logistic regression...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28454372/distinguishing-between-intramural-pregnancy-and-choriocarcinoma-a-case-report
#10
Shan Su, Devendra Chavan, Kun Song, Dennis Chi, Guiyu Zhang, Xiaohui Deng, Li Li, Beihua Kong
Intramural pregnancy is a rare type of ectopic pregnancy with an unclear etiology. It may be associated with uterine wall injury and/or abnormal uterine conditions, such as adenomyosis, in certain cases. In the present report, a case of intramural pregnancy associated with adenomyosis is discussed. The patient was 34 years old and presented with amenorrhea for 40 days. Ultrasonography and magnetic resonance imaging revealed a mixed echogenic mass located within the posterior wall of the uterine fundus with abundant blood flow...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28437003/high-intensity-focused-ultrasound-for-the-treatment-of-adenomyosis-selection-criteria-efficacy-safety-and-fertility
#11
REVIEW
Lian Zhang, Fangwen Rao, Raymond Setzen
Adenomyosis is a disorder of uterus in which endometrial glands and stroma are present within the uterine musculature. The main clinical manifestations are dysmenorrhea and menorrhagia. Adenomyosis has a great impact on both the quality of life and fertility of women. The treatment of adenomyosis remains an immense challenge. Relevant articles were searched through MEDLINE and PubMed between 2000 and March 2017. The search terms of adenomyosis, magnetic resonance imaging (MRI) features of adenomyosis, high intensity focused ultrasound (HIFU), ultrasound-guided HIFU and MRgFUS were used...
June 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28416935/juvenile-cystic-adenomyoma-mimicking-a-uterine-anomaly-a-report-of-two-cases
#12
Vatsla Dadhwal, Aparna Sharma, Kavita Khoiwal
Juvenile cystic adenomyoma is a rare form of adenomyosis and described as a new type of mullerian anomaly in literature. We are presenting two cases of juvenile cystic adenomyoma which were misdiagnosed preoperatively as unicornuate uterus with haematometra in a non-communicating rudimentary horn. The mainstay of treatment is complete resection of lesion.
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28397200/impact-of-pelvic-magnetic-resonance-imaging-findings-in-the-indication-of-uterine-artery-embolization-in-the-treatment-of-myoma
#13
Norma Maria Tenório Brito Pires, Emmanuelle Tenório Godoi, Dinaldo Cavalcanti Oliveira, Simone Cristina Soares Brandão, Carlos Coutinho Abath, Pedro Pires, Edward Araujo Júnior
OBJECTIVES: To assess the impact of pelvic magnetic resonance imaging (MRI) findings in the indication for uterine-artery embolization in women with fibroids, as well as the correlation between MRI and ultrasound (US) examinations for diagnosing adenomyosis. MATERIAL AND METHODS: A retrospective observational study was performed through the analysis of the medical records of 263 women referred for uterine-artery embolization as treatment for fibroids after undergoing US and MRI examinations...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28389633/leonurine-attenuates-hyperalgesia-in-mice-with-induced-adenomyosis
#14
Jichan Nie, Xishi Liu
BACKGROUND Adenomyosis, defined as the invasion of endometrial glands and stroma into the myometrium, is a common gynecological disorder. In the present study we report on the effect of leonurine on ICR mice with adenomyosis induced by neonatal tamoxifen. MATERIAL AND METHODS After being treated with tamoxifen for 4, 8, and 12 weeks, we assessed body weight and pain modulation in mice in hotplate tests. The mice were divided into 5 groups: a low-dose leonurine treatment group, a high-dose leonurine treatment group, a valproic acid (VPA) treatment group, a vehicle only treatment group, and a blank control group...
April 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28377357/-role-of-estrogen-estrogen-receptors-and-aromatase-in-the-pathogenesis-of-uterine-adenomyosis
#15
Yu-Yan Zeng, Yong-Ge Guan, Kun-Yin Li
OBJECTIVE: To study the role of estrogen (E2), estrogen receptor (ER) and aromatase (P450arom) in the pathogenesis of uterine adenomyosis. METHODS: Paraffin-embedded specimens of the uterine tissue from patients with uterine adenomyosis and patients with cervical lesions (CIN; control) were examined for expressions of E2, ER and P450arom by immunohistochemistry and ELISA. The cells isolated from the lesions of patients with adenomyosis were cultured in vitro, and the changes in cell growth in response to treatments with E2, ER inhibitor, ER inhibitor + E2, estrogen deprivation, and estrogen deprivation+ ICI182780 were assessed using CCK-8 method...
March 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28339446/pulsed-radiofrequency-ablation-of-pudendal-nerve-for-treatment-of-a-case-of-refractory-pelvic-pain
#16
Vadim Petrov-Kondratov, Avneesh Chhabra, Stephanie Jones
Pudendal neuralgia (PN) is a result of pudendal nerve entrapment or injury, also called "Alcock syndrome." Pain that develops is often chronic, and at times debilitating. If conservative measures fail, invasive treatment modalities can be considered. The goal of this case report is to add to a small body of literature that a pulsed radiofrequency (PRF) ablation can be effectively used to treat PN and to show that high resolution MR neurography imaging can be used to detect pudendal neuropathy. CASE PRESENTATION: We present a case of a 51-year-old woman with 5 years of worsening right groin and vulva pain...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28331289/transcriptome-analysis-of-endometrial-tissues-following-gnrh-agonist-treatment-in-a-mouse-adenomyosis-model
#17
Song Guo, Xiaowei Lu, Ruihuan Gu, Di Zhang, Yijuan Sun, Yun Feng
PURPOSE: Adenomyosis is a common, benign gynecological condition of the female reproductive tract characterized by heavy menstrual bleeding and dysmenorrhea. Gonadotropin-releasing hormone (GnRH) agonists are one of the medications used in adenomyosis treatment; however, their underlying mechanisms are poorly understood. Moreover, it is difficult to obtain endometrial samples from women undergoing such treatment. To overcome this, we generated an adenomyosis mouse model, which we treated with an GnRH agonist to determine its effect on pregnancy outcomes...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28267526/high-intensity-focused-ultrasound-treatment-of-adenomyosis-the-relationship-between-the-features-of-magnetic-resonance-imaging-on-t2-weighted-images-and-the-therapeutic-efficacy
#18
Chunmei Gong, Raymond Setzen, Zhongqiong Liu, Yunchang Liu, Bin Xie, Aixingzi Aili, Lian Zhang
OBJECTIVES: To investigate the relationship between the features of magnetic resonance imaging (MRI) on T2 weighted images (T2WI) and the therapeutic efficacy of high intensity focused ultrasound (HIFU) on adenomyosis. MATERIALS AND METHODS: From January 2011 to November 2015, four hundred and twenty-eight patients with symptomatic adenomyosis were treated with HIFU. Based on the signal intensity and the number of hyperintense foci in the adenomyotic lesions on T2WI, the patients were classified into groups...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28238590/the-current-status-of-hormonal-therapies-for-heavy-menstrual-bleeding
#19
REVIEW
Oskari Heikinheimo, Ian Fraser
Hormonal treatment of abnormal uterine bleeding (AUB), especially bleeding related to endometrial causes (AUB-E), ovulatory dysfunction (AUB-O) and coagulopathy (AUB-C), and to some extent, uterine leiomyomas and adenomyosis, has become the first-line evidence-based management strategy during recent years. Hormonal treatment of heavy menstrual bleeding (HMB) is also endorsed as the first line of treatment in several international guidelines. In the present article, we review the efficacy of the commonly used and widely available hormonal treatments of AUB-O, AUB-E and AUB-C...
April 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28183227/molecular-characteristics-of-the-endometrium-in-uterine-adenomyosis-and-its-biochemical-microenvironment
#20
Chih-Feng Yen, S Joseph Huang, Chyi-Long Lee, Hsin-Shih Wang, Shuen-Kuei Liao
Adenomyosis, which manifests with focally or diffusely scattered endometrial tissue within the uterine myometrium, is an endometriosis-like disease with controversial pathogenesis and compromised reproductive outcomes. This review, including the in vitro and in vivo studies performed on human or mouse models, is aimed to summarize the specific molecular characteristics of endometrium in the biochemical microenvironments of uterine adenomyosis. Many studies attributed the endometrium as the main cause of pathogenesis, with evidence of differential genetic expression and/or epigenetic modulation as well as estrogen-induced epithelial-mesenchymal transition...
January 1, 2017: Reproductive Sciences
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