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https://www.readbyqxmd.com/read/29685118/predictors-of-post-stroke-fever-and-infections-a-systematic-review-and-meta-analysis
#1
Maja Wästfelt, Yang Cao, Jakob O Ström
BACKGROUND: Fever after stroke is common, and often caused by infections. In the current study, we aimed to test the hypothesis that pneumonia, urinary tract infection and all-cause fever (thought to include at least some proportion of endogenous fever) have different predicting factors, since they differ regarding etiology. METHODS: PubMed was searched systematically for articles describing predictors for post-stroke pneumonia, urinary tract infection and all-cause fever...
April 23, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29678711/healthcare-associated-infections-after-subarachnoid-hemorrhage
#2
Yasser B Abulhasan, Najayeb Alabdulraheem, Ian Schiller, Susan P Rachel, Nandini Dendukuri, Mark R Angle, Charles Frenette
OBJECTIVE: Healthcare-associated infections (HAIs) after subarachnoid hemorrhage (SAH) are prevalent; however, data describing epidemiology of infection is limited. This study reports incidence rates, risk factors and the resulting SAH patient-related outcomes. METHODS: We studied the incidence of ICU-acquired HAIs over a 6-year period. We used Bayesian Model Averaging to identify risk factors associated with an increased risk of HAIs, particularly urinary tract infections (UTI), pneumonia and ventriculostomy-associated infections (VAI)...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29657204/urinary-tract-infection-in-renal-transplant-recipients-at-a-tertiary-care-center-in-india
#3
Debabrata Mukherjee, Sourabh Sharma, Ranjith K Nair, Bhaskar Datt, Dhawal Arora, Ananth Rao
Our objective was to determine incidence, predisposing factors, and microbiological profile of urinary tract infection (UTI) in renal transplant recipients in our center. This was cross-sectional observational study, conducted at the Department of Nephrology, Army Hospital Research and Referral, Delhi, India. Two hundred and ten renal transplant recipients were studied over one year. Out of 210 transplant recipients, 69 (32.86%) had UTI. Majority (59/69) had undergone live renal transplantation and 10 cases had received cadaveric grafts...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29649541/efficacy-and-safety-of-sodium-glucose-cotransporter-2-inhibitors-in-patients-with-type-2-diabetes-and-moderate-renal-function-impairment-a-systematic-review-and-meta-analysis
#4
Lin Zhang, Mei Zhang, Qingguo Lv, Nanwei Tong
AIMS: A systematic review and meta-analysis was conducted to evaluate the clinical efficacy and safety of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes (T2D) and moderate renal function impairment. METHODS: Embase, Medline, and Cochrane Central were searched, and randomized controlled trials comparing SGLT2 inhibitors to placebos and other drugs for T2D were collected. RESULTS: Seven RCTs with a total of 3,307 participants were included, and the overall bias was low...
April 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29643881/urinary-tract-infections-in-the-geriatric-patients
#5
Yesim Alpay, Nevil Aykin, Pinar Korkmaz, Hakki Mustafa Gulduren, Figen Cevik Caglan
Objective: Urinary tract infections (UTI) are the second most common infection in geriatric population. This study investigated clinical findings, diagnostic approaches, complicating factors, prognosis, causative microorganisms and antimicrobial susceptibility in geriatric patients diagnosed with UTI. Methods: A total of 140 hospitalised patients with UTIs were evaluated within three years between January 2011-January 2015 at the Eskisehir Yunus Emre State Hospital...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29620642/in-hospital-mortality-and-morbidity-of-pediatric-scoliosis-surgery-in-japan-analysis-using-a-national-inpatient-database
#6
Yuki Taniguchi, Takeshi Oichi, Junichi Ohya, Hirotaka Chikuda, Yasushi Oshima, Yoshitaka Matsubayashi, Hiroki Matsui, Kiyohide Fushimi, Sakae Tanaka, Hideo Yasunaga
Several previous reports have elucidated the mortality and incidence of complications after pediatric scoliosis surgery using nationwide databases. However, all of these studies were conducted in North America. Hence, this study aimed to identify the incidence and risk factors for in-hospital mortality and morbidity in pediatric scoliosis surgery, utilizing the Diagnosis Procedure Combination database, a national inpatient database in Japan.We retrospectively extracted data for patients aged less than 19 years who were admitted between 01 June 2010 and 31 March 2013 and underwent scoliosis surgery with fusion...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29604389/effects-of-sodium-glucose-cotransporter-2-inhibitors-on-cardiovascular-disease-death-and-safety-outcomes-in-type-2-diabetes-a-systematic-review
#7
REVIEW
Karin Rådholm, Jason Hy Wu, Muh Geot Wong, Celine Foote, Gregory Fulcher, Kenneth W Mahaffey, Vlado Perkovic, Bruce Neal
AIM: Sodium glucose co-transporter 2 (SGLT2) inhibitors appear to protect against increased risks of cardiovascular and kidney disease in patients with type 2 diabetes but also cause some harms. Whether effects are comparable across drug class or specific to individual compounds is unclear. This meta-analysis assessed the class and individual compound effects of SGLT2 inhibition versus control on cardiovascular events, death, kidney disease and safety outcomes in patients with type 2 diabetes...
March 28, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29596766/-bacteriuria-cochrane-database-syst-rev-2015-4-cd009534
#8
Miguel Bigotte Vieira, Mariana Alves, João Costa, António Vaz-Carneiro
Asymptomatic bacteriuria is frequently detected in women aged up to 60 years, patients with diabetes and elderly patients. The benefit of antibiotic treatment for this condition is controversial. The objective of this Cochrane systematic review was to assess the effectiveness and safety of antibiotic treatment for asymptomatic bacteriuria in adults. A systematic review of the literature up to 24 February 2015 was performed using the Cochrane Renal Group's Specialised Register. Randomised controlled trials (RCTs) and quasirandomised controlled trials comparing antibiotics to placebo or no treatment for asymptomatic bacteriuria in adults were included...
February 28, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29569576/urinary-tract-infection-due-to-fusarium-oxysporum-in-an-immunocompetent-patient-with-chronic-kidney-disease
#9
Khetan Seema, Khetan Prakash, Katkar Venkatesh, Kusulkar Minal
Infections due to Fusarium species are collectively referred to as fusariosis. Fusarium oxysporum has been reported to cause keratitis, onychomycosis, skin infections, catheter associated fungemia and has not been described as a cause of urinary tract infection. Here, we present the first case of fusariosis with urinary tract involvement in a 67 year old male, with chronic kidney disease and type 2 diabetes mellitus. This case illustrates the ever increasing spectrum of rare but offending pathogenic fungi. Early diagnosis of infection with a specific pathogen may lead to changes in antifungal therapy and may be critical for an improved outcome...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29548713/cycling-and-female-sexual-and-urinary-function-results-from-a-large-multinational-cross-sectional-study
#10
Thomas W Gaither, Mohannad A Awad, Gregory P Murphy, Ian Metzler, Thomas Sanford, Michael L Eisenberg, Siobhan Sutcliffe, E Charles Osterberg, Benjamin N Breyer
BACKGROUND: Bicycle riding has become an increasingly popular mode of transportation and exercise, especially among women, and previous studies have demonstrated a relationship between cycling and sexual dysfunction, albeit using non-validated questionnaires. AIM: We aimed to explore the relationship between cycling and sexual and urinary dysfunction. METHODS: Cyclists were recruited to complete a survey through Facebook advertisements and outreach to sporting clubs across 5 English-speaking countries...
March 6, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29541644/levels-of-urinary-trypsin-inhibitor-and-structure-of-its-chondroitin-sulphate-moiety-in-type-1-and-type-2-diabetes
#11
Antonio Junior Lepedda, Gabriele Nieddu, Silvia Rocchiccioli, Nadia Ucciferri, Michela Idini, Pierina De Muro, Marilena Formato
Background: Diabetes mellitus is a global health problem representing the fifth leading cause of mortality and a major risk factor for cardiovascular diseases. In the last years, we reported an association among urinary trypsin inhibitor (UTI), a small proteoglycan that plays pleiotropic roles in many inflammatory processes, and both type 1 and 2 diabetes and developed a method for its direct quantitation and structural characterization. Methods: Urine from 39 patients affected by type 1 diabetes, 32 patients with type 2 diabetes, and 52 controls were analysed...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29540408/postpartum-urinary-tract-infection-by-mode-of-delivery-a-danish-nationwide-cohort-study
#12
Tina Djernis Gundersen, Lone Krebs, Ellen Christine Leth Loekkegaard, Steen Christian Rasmussen, Julie Glavind, Tine Dalsgaard Clausen
OBJECTIVES: To examine the association between postpartum urinary tract infection and intended mode of delivery as well as actual mode of delivery. DESIGN: Retrospective cohort study. SETTING AND PARTICIPANTS: All live births in Denmark between 2004 and 2010 (n=450 856). Births were classified by intended caesarean delivery (n=45 053) or intended vaginal delivery (n=405 803), and by actual mode of delivery: spontaneous vaginal delivery, operative vaginal delivery, emergency or planned caesarean delivery in labour or prelabour...
March 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29535389/combination-of-sodium-glucose-cotransporter-2-inhibitor-and-dipeptidyl-peptidase-4-inhibitor-in-type-2-diabetes-a-systematic-review-with-meta-analysis
#13
Se Hee Min, Jeong-Hwa Yoon, Sun Joon Moon, Seokyung Hahn, Young Min Cho
Sodium glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP4) inhibitors have complementary mode of action. For the meta-analysis comparing the efficacy and safety between SGLT2 inhibitor plus DPP4 inhibitor (SGLT2i/DPP4i) and placebo plus DPP4 inhibitor (PCB/DPP4i) in patients with type 2 diabetes mellitus (T2DM), we selected randomized controlled trials from electronic databases by predefined criteria. The primary outcome of interest was the change in glycated hemoglobin A1c (HbA1c) from baseline...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29526624/an-expanded-prevention-quality-diabetes-composite-quantifying-the-burden-of-preventable-hospitalizations-for-older-adults-with-diabetes
#14
Chin-Lin Tseng, Orysya Soroka, Leonard M Pogach
AIM: To expand the existing United States Agency for Health Research and Quality (AHRQ) Diabetes composite (AHRQ-DC) to include additional preventable hospitalizations specific or relevant to diabetes. METHODS: A cross-sectional analysis of 834,696 veteran patients with diabetes aged ≥65 years in 2012. An Expanded Diabetes Composite (Expanded-DC) was developed utilizing: (1) the diabetes-specific category: the AHRQ-DC (short-term and long-term complications, uncontrolled diabetes, lower extremity amputations) and two proposed conditions: hypoglycemia and lower extremity ulcers/inflammation/infections (LEU) and (2) the diabetes-relevant category: the AHRQ-Acute Composite (dehydration, pneumonia, urinary tract infections) and one proposed condition, acute kidney injury (AKI)...
February 2, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29524188/adverse-drug-events-associated-with-low-dose-10-mg-versus-high-dose-25-mg-empagliflozin-in-patients-treated-for-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
Xia Dai, Zu-Chun Luo, Lu Zhai, Wen-Piao Zhao, Feng Huang
INTRODUCTION: Empagliflozin is a new, emerging oral hypoglycemic agent (OHA) which has shown significant benefits in type 2 diabetes mellitus (T2DM) patients with cardiovascular disease. In this analysis, our aim was to systematically compare the adverse drug events (ADEs) associated with a low (10 mg) versus a high (25 mg) dose of empagliflozin as (1) monotherapy, (2) as an add-on to other OHAs, and (3) as an add-on specifically to metformin, in patients who were treated for T2DM. METHODS: This was a systematic review and meta-analysis of randomized controlled trials that compared empagliflozin 10 mg versus 25 mg in patients who were treated for T2DM and which reported adverse drug reactions as their clinical endpoints...
March 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29520146/prevalence-risk-factors-and-microorganisms-of-urinary-tract-infections-in-patients-with-type-2-diabetes-mellitus-a-retrospective-study-in-china
#16
Ke He, Yun Hu, Jun-Cheng Shi, Yun-Qing Zhu, Xiao-Ming Mao
Background: Urinary tract infections (UTIs) occur more frequently in diabetic patients. This study was conducted to investigate the prevalence, risk factors and microorganisms of UTIs in Chinese patients with type 2 diabetes (T2D). Patients and methods: A total of 3,652 Chinese inpatients with T2D were reviewed and data on their clinical characteristics, symptoms of UTIs, random blood glucose, HbA1c, glutamic acid decarboxylase antibody, insulin autoantibody, albumin excretion rate in 24-hour urine, urine culture and susceptibility to antibiotics, and so on were collected...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29514287/mannose-binding-lectin-genotypes-and-outcome-in-end-stage-renal-disease-a-prospective-cohort-study
#17
Therese Adrian, Mads Hornum, Frank Eriksson, Jesper M Hansen, Katrine Pilely, Peter Garred, Bo Feldt-Rasmussen
Background: Patients with end-stage renal disease (ESRD) have high morbidity and mortality rates, with cardiovascular diseases and infections being the major causes of death. Mannose-binding lectin (MBL) has been suggested to play a protective role in this regard. The aim of this study was to investigate a possible clinical association of MBL genotypes (MBL2) with outcome among patients on dialysis or with a functioning graft. Methods: A total of 98 patients with ESRD accepted for living-donor renal transplantation or on the waiting list for transplantation were included and prospectively followed for an average of 9 years (range 7...
March 3, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29491858/characterization-of-asymptomatic-bacteriuria-escherichia-coli-isolates-in-search-of-alternative-strains-for-efficient-bacterial-interference-against-uropathogens
#18
Christoph Stork, Beáta Kovács, Barnabás Rózsai, Johannes Putze, Matthias Kiel, Ágnes Dorn, Judit Kovács, Szilvia Melegh, Andreas Leimbach, Tamás Kovács, György Schneider, Monika Kerényi, Levente Emödy, Ulrich Dobrindt
Asymptomatic bacterial colonization of the urinary bladder (asymptomatic bacteriuria, ABU) can prevent bladder colonization by uropathogens and thus symptomatic urinary tract infection (UTI). Deliberate bladder colonization with Escherichia coli ABU isolate 83972 has been shown to outcompete uropathogens and prevent symptomatic UTI by bacterial interference. Many ABU isolates evolved from uropathogenic ancestors and, although attenuated, may still be able to express virulence-associated factors. Our aim was to screen for efficient and safe candidate strains that could be used as alternatives to E...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29485006/risks-associated-with-sglt2-inhibitors-an-overview
#19
Mahakpreet Singh, Anoop Kumar
Sodium glucose co-transport 2 inhibitors (SGLT2-i) are the new class of anti-diabetic medications which are the recently approved (2013) by FDA for the treatment of diabetes. These inhibitors block the SGLT2 protein which involved in glucose reabsorption from proximal renal tubule which results in increased glucose excretion and lower blood glucose levels. These inhibitors exert favourable effects beyond glucose control such as consistent body weight, blood pressure, and serum uric acid reductions. Canagliflozin, Dapagliflozin, and Empagliflozin belong to the class of SGLT2 inhibitors...
February 25, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29484489/sglt-2-inhibitors-and-the-risk-of-infections-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Robert Puckrin, Marie-Philippe Saltiel, Pauline Reynier, Laurent Azoulay, Oriana H Y Yu, Kristian B Filion
AIMS: There is concern about the infection-related safety profile of sodium-glucose co-transporter 2 (SGLT-2) inhibitors. We aimed to determine the effect of SGLT-2 inhibitors on genitourinary and other infections via systematic review and meta-analysis of randomized controlled trials (RCTs). METHODS: We conducted a systematic search of Medline, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov to identify double-blinded RCTs enrolling ≥ 50 patients with type 2 diabetes which compared an SGLT-2 inhibitor to placebo or active comparator...
February 27, 2018: Acta Diabetologica
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