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https://www.readbyqxmd.com/read/29447854/risk-factors-associated-complications-for-postoperative-urinary-retention-after-lumbar-surgery-for-lumbar-spinal-stenosis
#1
Joshua L Golubovsky, Haariss Ilyas, Jinxiao Chen, Joseph E Tanenbaum, Thomas E Mroz, Michael P Steinmetz
BACKGROUND CONTEXT: Postoperative Urinary Retention (POUR) is a very common post-operative complication of all surgeries (5 - 70%) that may lead to complications such as urinary tract infection (UTI), bladder over-distention, autonomic dysregulation, and increased postoperative length of stay (LOS). Within the field of spine surgery, the reported incidence of POUR is highly variable (5.6 - 38%). Lack of clear stratification of surgical level, spinal pathology, and inadequate sample size is a major limitation of available studies concerning POUR following spine surgery that may lead to inconsistency in the incidence of POUR and the ability to model its occurrence and consequences...
February 12, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29446523/safety-and-tolerability-of-dapagliflozin-saxagliptin-and-metformin-in-combination-post-hoc-analysis-of-concomitant-add-on-versus-sequential-add-on-to-metformin-and-of-triple-versus-dual-therapy-with-metformin
#2
Stefano Del Prato, Julio Rosenstock, Ricardo Garcia-Sanchez, Nayyar Iqbal, Lars Hansen, Eva Johnsson, Hungta Chen, Chantal Mathieu
The safety of triple oral therapy with dapagliflozin plus saxagliptin plus metformin, versus dual therapy with dapagliflozin or saxagliptin plus metformin, was compared in a post hoc analysis of three randomized trials of sequential or concomitant add-on of dapagliflozin and saxagliptin to metformin. In the concomitant add-on trial, patients with type 2 diabetes on stable metformin received dapagliflozin 10 mg/day plus saxagliptin 5 mg/day. In sequential add-on trials, patients on metformin plus either saxagliptin 5 mg/day or dapagliflozin 10 mg/day received add-on dapagliflozin 10 mg/day or saxagliptin 5 mg/day, respectively...
February 15, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29437306/clinical-predictors-of-ceftriaxone-resistance-in-microorganisms-causing-febrile-urinary-tract-infections-in-men
#3
Javier Ramos Lázaro, Alex Smithson, Neus Jovè Vidal, María Teresa Batida Vila
OBJECTIVES: Because of high rates of resistance to fluoroquinolones, ceftriaxone has become one of the main options for treating febrile urinary tract infection (FUTI). This study aimed to identify predictors of ceftriaxone resistance in community-acquired FUTIs in men. MATERIAL AND METHODS: Cross-sectional ambispective study enrolling men with FUTIs treated in the emergency department of a local area hospital in Spain. RESULTS: A total of 552 FUTI episodes were studied; 103 (18...
February 2018: Emergencias: revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29421810/is-there-a-role-for-double-j-stent-culture-in-contemporary-urology
#4
Diomidis Kozyrakis, Stefanos Perikleous, Styliani-Elissavet Chatzistamou, Dimitris Kateris, Georgios Soukias, Anastasios Karatzas, Ioannis Dimitriadis
INTRODUCTION: To present the incidence of bacterial colonization on ureteral double J stents (DJS); isolate the uropathogens; define the rate of multi-resistant bacteria strains (MRBS) and present their clinical importance. MATERIALS AND METHODS: <unterline></unterline> The whole body of 105 DJSs was examined for the presence of uropathogens. RESULTS: The main etiology for stent placement was lithiasis (57.1%). The most frequently cultured microorganisms were staphylococcus (28...
February 8, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29419917/long-term-efficacy-and-safety-of-ertugliflozin-monotherapy-in-patients-with-inadequately-controlled-t2dm-despite-diet-and-exercise-vertis-mono-extension-study
#5
Ronnie Aronson, Juan Frias, Allison Goldman, Amanda Darekar, Brett Lauring, Steven G Terra
AIM: This phase III, multicenter, randomised study evaluated the efficacy and safety of ertugliflozin monotherapy in adults with inadequately controlled type 2 diabetes (glycated haemoglobin [HbA1c] 7.0% to 10.5% [53-91 mmol/mol]) despite diet and exercise. MATERIALS AND METHODS: The 52-week study comprised a 26-week, double-blind, placebo-controlled period (phase A) where 461 participants received placebo, ertugliflozin 5-mg/day, or ertugliflozin 15-mg/day. This was followed by a 26-week active-controlled period (phase B) where participants in the placebo group who had not received glycaemic rescue therapy had blinded metformin added...
February 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29419786/disease-and-economic-burden-of-hospitalizations-attributable-to-diabetes-mellitus-and-its-complications-a-nationwide-study-in-brazil
#6
Michelle Quarti Machado Rosa, Roger Dos Santos Rosa, Marcelo G Correia, Denizar V Araujo, Luciana R Bahia, Cristiana M Toscano
Diabetes is associated with a significant burden globally. The costs of diabetes-related hospitalizations are unknown in most developing countries. The aim of this study was to estimate the total number and economic burden of hospitalizations attributable to diabetes mellitus (DM) and its complications in adults from the perspective of the Brazilian Public Health System in 2014. Data sources included the National Health Survey (NHS) and National database of Hospitalizations (SIH). We considered diabetes, its microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular complications (coronary heart disease, cerebrovascular disease, and peripheral arterial disease), respiratory and urinary tract infections, as well as selected cancers...
February 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29395295/-emphysematous-cystitis-report-of-one-case
#7
J Biogeau, M Lamandé, H Ripault, I Léger, V Dardaine-Giraud
INTRODUCTION: Emphysematous cystitis is a rare urinary tract infection characterized by gas in the bladder wall and lumen. CASE REPORT: We report a 92-year-old women admitted with confusion and abdominal pain without fever. Her past medical history included diabetes, urinary incontinence, high blood pressure and mild cognitive impairment. A computed tomography scan (CT scan) revealed emphysematous cystitis. The patient completely recovered within ten days. The main characteristics and the treatment of this uncommon disorder are presented...
January 27, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29371812/azole-resistance-caused-by-increased-drug-efflux-in-candida-glabrata-isolated-from-the-urinary-tract-of-a-dog-with-diabetes-mellitus
#8
Minchul Kim, Hyekyung Lee, Sun-Young Hwang, Inhyung Lee, Won Hee Jung
A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole antifungal drugs. To understand the mechanism of azole resistance in this isolate, the sequences and expression levels of the genes involved in drug resistance were analyzed. The results of our analysis showed that increased drug efflux, mediated by overexpression of ATP transporter genes CDR1 and PDH1, is the main cause of azole resistance of the C...
December 2017: Mycobiology
https://www.readbyqxmd.com/read/29370606/re-bacterial-resistance-in-urinary-tract-infections-in-patients-with-diabetes-matched-with-patients-without-diabetes
#9
Edward M Schaeffer
No abstract text is available yet for this article.
August 2017: Journal of Urology
https://www.readbyqxmd.com/read/29338897/asymptomatic-bacteriuria-and-urinary-tract-infection-in-pregnant-women-with-and-without-diabetes-cohort-study
#10
Caroline Schneeberger, Jan Jaap H M Erwich, Edwin R van den Heuvel, Ben W J Mol, Alewijn Ott, Suzanne E Geerlings
OBJECTIVE: To compare the prevalence of asymptomatic bacteriuria (ASB) and the incidence of urinary tract infection (UTI) in pregnant women with and without diabetes mellitus (DM) or gestational DM (GDM). STUDY DESIGN: We performed a cohort study in five hospitals and two midwifery clinics in the Netherlands. Pregnant women with and without DM or GDM were screened for the presence of ASB around 12 and 32 weeks' gestation. Characteristics of participants as well as outcome data were collected from questionnaires and medical records...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29326206/whole-genome-draft-sequences-of-nine-asymptomatic-escherichia-coli-bacteriuria-isolates-from-diabetic-patients
#11
Christoph Stork, Beáta Kovács, Eva Trost, Tamás Kovács, György Schneider, Barnabás Rózsai, Monika Kerényi, Levente Emődy, Ulrich Dobrindt
Escherichia coli can colonize the urinary bladder without causing a disease response in the host. This asymptomatic bacteriuria (ABU) can protect against recurrent symptomatic urinary tract infection by virulent bacteria. Here, we report the whole-genome sequences of nine E. coli ABU isolates from diabetic patients.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29316236/long-term-safety-and-efficacy-of-tofogliflozin-add-on-to-insulin-in-patients-with-type-2-diabetes-results-from-a-52-week-multicenter-randomized-double-blind-open-label-extension-phase-4-study-in-japan-j-step-ins
#12
Yasuo Terauchi, Masahiro Tamura, Masayuki Senda, Ryoji Gunji, Kohei Kaku
AIMS: To evaluate the long-term safety and efficacy of tofogliflozin as an add-on treatment to insulin over 52 weeks. MATERIALS AND METHODS: This 52-week, multicenter, Phase 4 study consisted of a 16-week, randomized, double-blind, placebo-controlled phase and a 36-week open label extension phase (NCT02201004). Japanese patients with type 2 diabetes mellitus aged 20-75 years with suboptimal glycemic control (7.5%-10.5%) on insulin monotherapy (basal-bolus, bolus, premix [low and high], and basal) or on combination therapy of basal insulin and dipeptidyl peptidase-4 inhibitor were eligible for participation...
January 5, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29313282/ertugliflozin-and-sitagliptin-co-initiation-in-patients-with-type-2-diabetes-the-vertis-sita-randomized-study
#13
Sam Miller, Tania Krumins, Haojin Zhou, Susan Huyck, Jeremy Johnson, Gregory Golm, Steven G Terra, James P Mancuso, Samuel S Engel, Brett Lauring
INTRODUCTION: Ertugliflozin is an oral sodium-glucose cotransporter 2 inhibitor that is being developed to treat type 2 diabetes mellitus (T2DM). This study assessed the efficacy and safety of co-initiation of ertugliflozin and sitagliptin compared with placebo in patients with T2DM inadequately controlled on diet and exercise. METHODS: In this phase III, randomized, double-blind, multicenter, placebo-controlled 26-week study (NCT02226003), patients with T2DM and glycated hemoglobin (HbA1c) 8...
January 8, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29282633/ertugliflozin-compared-with-glimepiride-in-patients-with-type-2-diabetes-mellitus-inadequately-controlled-on-metformin-the-vertis-su-randomized-study
#14
Priscilla Hollander, Jie Liu, Julie Hill, Jeremy Johnson, Zhi Wei Jiang, Gregory Golm, Susan Huyck, Steven G Terra, James P Mancuso, Samuel S Engel, Brett Lauring
INTRODUCTION: This study assessed the safety and efficacy of ertugliflozin (an oral sodium-glucose cotransporter 2 inhibitor) vs. glimepiride in patients with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin. METHODS: This phase III, double-blind, non-inferiority study (NCT01999218) randomized patients with HbA1c ≥ 7.0% and ≤ 9.0% on stable metformin ≥ 1500 mg/day 1:1:1 to ertugliflozin 15 or 5 mg once-daily (QD), or glimepiride (titrated from 1 mg QD)...
December 27, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29249586/medium-to-long-term-outcomes-of-bariatric-surgery-in-older-adults-with-super-obesity
#15
Aly Elbahrawy, Alexandre Bougie, Sarah-Eve Loiselle, Sebastian Demyttenaere, Olivier Court, Amin Andalib
BACKGROUND: Indications and outcomes of bariatric surgery in older adults suffering from morbid obesity remain controversial. We aimed to evaluate safety and medium to long-term outcomes of bariatric procedures in this patient population. SETTING: University Hospital, Canada. METHODS: This is a single-center retrospective study of a prospectively collected database. We included patients aged ≥60 years who underwent sleeve gastrectomy, Roux-en-Y gastric bypass, or biliopancreatic diversion with duodenal switch between January 2006 and December 2014 and had at least 2 years of follow-up...
November 10, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29247109/evaluation-of-anticoagulation-status-for-atrial-fibrillation-on-early-ischaemic-stroke-outcomes-a-registry-based-prospective-cohort-study-of-acute-stroke-care-in-surrey-uk
#16
Thang S Han, Christopher H Fry, David Fluck, Brendan Affley, Giosue Gulli, Christopher Barrett, Puneet Kakar, Tasmin Patel, Sapna Sharma, Pankaj Sharma
OBJECTIVE: The relationship of anticoagulation therapies with stroke severity and outcomes have been well documented in the literature. However, none of the previous research has reported the relationship of atrial fibrillation (AF)/anticoagulation therapies with urinary tract infection (UTI), pneumonia and length of stay in hyperacute stroke units (HASUs). The present study aimed to evaluate AF and anticoagulation status in relation to early outcomes in 1387 men (median age=75 years, IQR=65-83) and 1371 women (median age=83 years, IQR=74-89) admitted with acute ischaemic stroke to HASUs in Surrey between 2014 and 2016...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29246012/characterization-of-the-urinary-microbiota-of-elderly-women-and-the-effects-of-type-2-diabetes-and-urinary-tract-infections-on-the-microbiota
#17
Fengping Liu, Zongxin Ling, Yonghong Xiao, Qing Yang, Li Zheng, Ping Jiang, Lanjuan Li, Wei Wang
Evidence shows that urine has complex bacterial profiles with considerable variation between individuals. Aging and age-related conditions can lead to the changes to the composition of urine, which means that the available nutrition for bacteria in the bladder changes with age. We explored the characteristics of the urinary microbiota of elderly women and whether these are associated with age-related conditions such as diabetes and urinary tract infections. An elderly and a non-elderly cohort of women were included...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29245978/chronic-kidney-disease-is-associated-with-a-risk-of-higher-mortality-following-total-knee-arthroplasty-in-diabetic-patients-a-nationwide-population-based-study
#18
Liang-Tseng Kuo, Su-Ju Lin, Chi-Lung Chen, Pei-An Yu, Wei-Hsiu Hsu, Tien-Hsing Chen
Diabetes and chronic kidney disease (CKD) are associated with a higher rate of complications in patients undergoing total knee arthroplasty (TKA). The purpose of this study was to determine the effects of CKD and diabetes in patients after TKA. Diabetic patients who received unilateral primary TKA between January 2008 and December 2011 were enrolled. The follow-up period was more than 6 months. The primary outcome was a TKA-related infection and the secondary outcome was all-cause mortality. The study cohort included 13844 patients who were followed for a mean period of 2 years, of whom 1459 (10...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29244784/factors-associated-to-inpatient-mortality-rates-in-type-2-diabetic-patients-a-cross-sectional-analytical-study-in-three-peruvian-hospitals
#19
Noé Atamari-Anahui, Franklin W Martinez-Ninanqui, Liz Paucar-Tito, Luz Morales-Concha, Alejandra Miranda-Chirau, Marco Antonio Gamarra-Contreras, Carlos Antonio Zea-Nuñez, Christian R Mejia
INTRODUCTION: Diabetes mortality has increased in recent years. In Peru, there are few studies on in-hospital mortality due to type 2 diabetes in the provinces. OBJECTIVE: To determine factors associated to hospital mortality in patients with diabetes mellitus type 2 in three hospitals from Cusco-Peru. METHODS: An analytical cross-sectional study was performed. All patients with diabetes mellitus type 2 hospitalized in the city of Cusco during the 2016 were included...
December 5, 2017: Medwave
https://www.readbyqxmd.com/read/29241659/a-novel-method-for-predicting-kidney-stone-type-using-ensemble-learning
#20
Yassaman Kazemi, Seyed Abolghasem Mirroshandel
The high morbidity rate associated with kidney stone disease, which is a silent killer, is one of the main concerns in healthcare systems all over the world. Advanced data mining techniques such as classification can help in the early prediction of this disease and reduce its incidence and associated costs. The objective of the present study is to derive a model for the early detection of the type of kidney stone and the most influential parameters with the aim of providing a decision-support system. Information was collected from 936 patients with nephrolithiasis at the kidney center of the Razi Hospital in Rasht from 2012 through 2016...
December 11, 2017: Artificial Intelligence in Medicine
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