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https://www.readbyqxmd.com/read/28527294/activation-of-hypoxia-signaling-in-stromal-progenitors-impairs-kidney-development
#1
Katharina Gerl, Dominik Steppan, Michaela Fuchs, Charlotte Wagner, Carsten Willam, Armin Kurtz, Birgül Kurt
Intrauterine hypoxia is a reason for impaired kidney development. The cellular and molecular pathways along which hypoxia exerts effects on nephrogenesis are not well understood. They are likely triggered by hypoxia-inducible transcription factors (HIFs), and their effects appear to be dependent on the cell compartment contributing to kidney formation. In this study, we investigated the effects of HIF activation in the developing renal stroma, which also essentially modulates nephron development from the metanephric mesenchyme...
May 17, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28508970/glomerulopathy-with-distinctive-fibrillar-deposits-but-lacking-glomerular-deposition-of-type-iii-collagen
#2
Tatsuo Yamamoto, Akashi Togawa, Masanobu Eguchi, Naro Ohashi, Hideo Yasuda, Yutaka Harita, Motoshi Hattori, Yutaka Yamaguchi, Kunio Ohyama
A 62-year-old woman with nephrotic syndrome underwent a renal biopsy. Under light microscopy, the biopsy findings included lobulation and enlargement of glomeruli, occasional thickening of glomerular capillary walls, and narrowing of the capillary lumen by swollen endothelial cells. Congo red staining was negative for amyloid. No significant intraglomerular fibrin deposition was found by phosphotungstic acid hematoxylin staining. Immunofluorescence microscopy showed no deposition of immunoglobulin G, A, or M; no κ or λ light chains; and no C3 or C1q...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28495930/adamts13-retards-progression-of-diabetic-nephropathy-by-inhibiting-intrarenal-thrombosis-in-mice
#3
Nirav Dhanesha, Prakash Doddapattar, Mehul R Chorawala, Manasa K Nayak, Koichi Kokame, Janice M Staber, Steven R Lentz, Anil K Chauhan
OBJECTIVE: ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type I repeats-13) prevents microvascular thrombosis by cleaving prothrombogenic ultralarge von Willebrand factor (VWF) multimers. Clinical studies have found association between reduced ADAMTS13-specific activity, ultralarge VWF multimers, and thrombotic angiopathy in patients with diabetic nephropathy. It remains unknown, however, whether ADAMTS13 deficiency or ultralarge VWF multimers have a causative effect in diabetic nephropathy...
May 11, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28495185/association-of-circulatory-asymmetric-dimethylarginine-adma-with-diabetic-nephropathy-in-asian-indians-and-its-causative-role-in-renal-cell-injury
#4
Isaivani Jayachandran, Saravanakumar Sundararajan, Prabu Paramasivam, Balachandar Venkatesan, Shanthirani C Subramanian, Muthuswamy Balasubramanyam, Viswanathan Mohan, Nagaraj Manickam
AIM: Asymmetric dimethylarginine (ADMA) is involved in the regulation of nitric oxide synthesis and in the maintenance of vascular tone and structure. But the role and status of ADMA in diabetes induced kidney injury is not clear. Hence this study is investigating the role of ADMA in the progression of kidney injury and its circulatory status in Asian Indians with and without diabetic nephropathy. METHODS: Recruited study subjects were divided into normal glucose tolerance (NGT), type 2 diabetes mellitus (T2DM) and T2DM with micro or macroalbuminuria...
May 8, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28490526/atp-citrate-lyase-is-essential-for-high-glucose-induced-histone-hyperacetylation-and-fibrogenic-gene-up-regulation-in-mesangial-cells
#5
Dilip K Deb, Yinyin Chen, Jian Sun, Youli Wang, Yan Chun Li
TThe goal of this study was to address the role of ATP-citrate lyase (ACL), an enzyme that converts citrate to acetyl-CoA, in high glucose (HG)-induced histone acetylation and pro-fibrotic gene expression. Our recent ChIP-Seq studies have demonstrated that HG induces genome-wide histone hyperacetylation in mesangial cells (MCs). Here we showed that exposure of MCs to HG markedly increased histone acetylation at the H3K9/14 and H3K18 marks and induced the expression of potent pro-fibrotic factors TGF-β1, TGF-β3 and CTGF...
May 10, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28485410/corrigendum-mir302-regulates-snai1-expression-to-control-mesangial-cell-plasticity
#6
Letizia De Chiara, Darrell Andrews, Ariane Watson, Giorgio Oliviero, Gerard Cagney, John Crean
No abstract text is available yet for this article.
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28484449/interleukin-6-signaling-pathway-and-its-role-in-kidney-disease-an-update
#7
REVIEW
Hua Su, Chun-Tao Lei, Chun Zhang
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28468042/-roles-of-pi3k-akt-pathway-in-aldose-reductase-in-promoting-expression-of-fibronectin-in-mesangial-cell
#8
P Hunag, Q Wu, Q M Xie, W Yi
No abstract text is available yet for this article.
May 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28465704/huang-gan-formula-eliminates-the-oxidative-stress-effects-of-advanced-oxidation-protein-products-on-the-divergent-regulation-of-the-expression-of-ages-receptors-via-the-jak2-stat3-pathway
#9
Quanwen Deng, Can Bu, Liqian Mo, Bin Lv, Shaolian Song, Xiaoyan Xiao, Guo Dan, Xixiao Yang
Chronic kidney disease (CKD) has a high prevalence and low cure rate and represents a significant health issue. Oxidative stress is common in CKD due to metabolic disorders, inflammation, and impaired renal function changing normal proteins into advanced oxidation protein products (AOPPs). Huang Gan formula (HGF) is a new type of traditional Chinese herbal medicine. Although we previously investigated the protective effects of HGF against oxidative stress, the mechanism of HGF in CKD is still not fully understood...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28457936/epigallocatechin-gallate-upregulates-nrf2-to-prevent-diabetic-nephropathy-via-disabling-keap1
#10
Weixia Sun, Xiuxia Liu, Haifeng Zhang, Yanyan Song, Tie Li, Xiaona Liu, Yanze Liu, Le Guo, Fuchun Wang, Ting Yang, Weiying Guo, Junduo Wu, Hang Jin, Hao Wu
Epigallocatechin gallate (EGCG) is the most abundant and effective green tea catechin and has been reported to attenuate diabetic nephropathy (DN). However, the mechanism by which EGCG ameliorates DN, till now, has remained unclear. EGCG is known as a potent activator of nuclear factor erythroid 2-related factor 2 (NRF2), which plays a key role in cellular defense against diabetes-induced oxidative stress and in the prevention of DN. In the present study, we tested whether NRF2 is required for EGCG protection against DN...
April 27, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28440482/kmup-1-attenuates-high-glucose-and-transforming-growth-factor-%C3%AE-1-induced-pro-fibrotic-proteins-in-mesangial-cells
#11
Sheng-Hsuan Lin, Ing-Jun Chen, Chao-Tang Chuang, Wan-Ting Ho, Lea-Yea Chuang, Jinn-Yuh Guh
We have previously demonstrated that KMUP-1, a xanthine-based nitric oxide enhancer, attenuates diabetic glomerulosclerosis, while increasing renal endothelial nitric oxide synthase expression in rats. However, the anti‑fibrotic mechanisms of KMUP‑1 treatment in diabetic nephropathy in terms of cell biology and transforming growth factor-β1 (TGF‑β1) remain unclear. Therefore, the present study involved investigating the effects of KMUP‑1 on high glucose (HG) or TGF‑β1‑induced pro‑fibrotic proteins in mouse mesangial (MES13) cells, and the effects of KMUP‑1 on streptozotocin (STZ)‑induced diabetic rats...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440442/role-of-the-wnt-%C3%AE-catenin-signaling-pathway-in-inducing-apoptosis-and-renal-fibrosis-in-5-6-nephrectomized-rats
#12
Xin Lin, Yan Zha, Xiang-Zhen Zeng, Rong Dong, Qing-Hua Wang, Dong-Tao Wang
Renal fibrosis is the final common pathway of all progressive renal disease. Excessive and chronic activation of the Wnt/β-catenin signaling pathway results in chronic kidney disease (CKD) progression. To mimic CKD, the present study used 5/6-nephrectomized rats, and alterations in kidney histology, expression of β‑catenin and renal cell apoptosis were assessed. In addition, mesangial cells were cultured in vitro and transfected with β‑catenin siRNA to evaluate the effect of blocking Wnt/β‑catenin signaling on cell apoptosis and the expression of markers of renal fibrosis...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28434946/hyperglycemia-induced-renal-p2x7-receptor-activation-enhances-diabetes-related-injury
#13
Robert I Menzies, John W R Booth, John J Mullins, Matthew A Bailey, Frederick W K Tam, Jill T Norman, Robert J Unwin
Diabetes is a leading cause of renal disease. Glomerular mesangial expansion and fibrosis are hallmarks of diabetic nephropathy and this is thought to be promoted by infiltration of circulating macrophages. Monocyte chemoattractant protein-1 (MCP-1) has been shown to attract macrophages in kidney diseases. P2X7 receptors (P2X7R) are highly expressed on macrophages and are essential components of pro-inflammatory signaling in multiple tissues. Here we show that in diabetic patients, renal P2X7R expression is associated with severe mesangial expansion, impaired glomerular filtration (≤40ml/min/1...
April 20, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28434671/resveratrol-improves-mitochondrial-function-in-the-remnant-kidney-from-5-6-nephrectomized-rats
#14
Yan Hui, Miaomiao Lu, Yarong Han, Hongli Zhou, Wei Liu, Lijing Li, Ruixia Jin
Mitochondrial dysfunction is involved in the pathogenesis of chronic kidney disease (CKD). Resveratrol has been demonstrated to be beneficial for the recovery of kidney diseases. In this study, the 5/6 nephrectomized rat was used as a CKD model and the TGF-β1-exposed mouse mesangial cells were used as an in vitro model. Pathological examination showed that resveratrol treatment attenuated glomerular injury in the remnant kidney of 5/6 nephrectomized rat. Additionally, resveratrol improved mitochondrial function in vivo and in vitro, as evidenced by increasing mitochondrial membrane potential, increasing ATP, decreasing reactive oxygen species production and enhancing activities of complex I and III...
April 20, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28431381/zeaxanthin-ameliorates-high-glucose-induced-mesangial-cell-apoptosis-through-inhibiting-oxidative-stress-via-activating-akt-signalling-pathway
#15
Changjiang Ying, Lei Chen, Shanshan Wang, Yizhen Mao, Hongwei Ling, Wei Li, Xiaoyan Zhou
Oxidative stress is a critical factor in the pathophysiology of diabetic kidney disease. Previous study shows that hyperglycaemia aggravates renal injury through oxidative stress in diabetic model, and antioxidants have beneficial effect on diabetic kidney disease. However, the role of antioxidants in the progression of diabetic kidney disease is poorly understood. The aim of this study was to clarify whether zeaxanthin, an antioxidant, could ameliorate mesangial cell injury and if so, identify the related mechanism underlying this protective effect...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28427241/egfr-inhibition-attenuates-diabetic-nephropathy-through-decreasing-ros-and-endoplasmic-reticulum-stress
#16
Zheng Xu, Yunjie Zhao, Peng Zhong, Jingying Wang, Qiaoyou Weng, Yuanyuan Qian, Jibo Han, Chunpeng Zou, Guang Liang
Diabetic nephropathy (DN) is a progressive kidney disease due to glomerular capillary damage in diabetic patients. Endoplasmic reticulum (ER) stress caused by reactive oxygen species (ROS) is associated with DN progression. Epidermal growth factor receptor (EGFR) mediates oxidative stress and damage of cardiomyocytes in diabetic mice. Here we demonstrated that AG1478, a specific inhibitor of EGFR, blocked EGFR and AKT phosphorylation in diabetic mice. Oxidative stress and ER stress markers were eliminated after AG1478 administration...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427080/rapamycin-induces-autophagy-and-reduces-the-apoptosis-of-podocytes-under-a-stimulated-condition-of-immunoglobulin-a-nephropathy
#17
Shikai Liang, Juan Jin, Bo Lin, Jianguang Gong, Yiwen Li, Qiang He
Backgroud/Aims: The aim of this study was to investigate the potential renoprotective effect of rapamycin on the autophagy of podocytes treated with the supernatant of mesangial cells cultured with aggregated IgA1 (aIgA1) from immunoglobulin A nephropathy (IgAN) patients. METHODS: Monomeric IgA1 (mIgA1) was isolated from the serum of IgAN patients or healthy volunteers, and then transformed to aIgA1 by heating. Subsequently, the aIgA1-mesangial cell supernatant was prepared by collecting the medium of mouse mesangial cells (MSC1097) cultured with aIgA1 (100 mg/L) from different IgAN patients or healthy volunteers for 48 h...
April 18, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28411025/klotho-down-regulates-egr-1-by-inhibiting-tgf-%C3%AE-1-smad3-signaling-in-high-glucose-treated-human-mesangial-cells
#18
Yang Li, Fang Hu, Meng Xue, Yi-Jie Jia, Zong-Ji Zheng, Ling Wang, Mei-Ping Guan, Yao-Ming Xue
Diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease worldwide and is associated with glomerular mesangial cell (MC) proliferation and excessive extracellular matrix (ECM) production. Klotho can attenuate renal fibrosis in part by inhibiting TGF-β1/Smad3 signaling in DKD. Early growth response factor 1 (Egr-1) has been shown to play a key role in renal fibrosis in part by facilitating the formation of a positive feedback loop involving TGF-β1. However, whether Klotho down-regulates Egr-1 by inhibiting TGF-β1/Smad3 signaling in DKD is unclear...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28402512/defective-trophoblast-invasion-underlies-fetal-growth-restriction-and-pre-eclampsia-like-symptoms-in-the-stroke-prone-spontaneously-hypertensive-rat
#19
G Barrientos, M Pussetto, M Rose, A C Staff, S M Blois, J E Toblli
STUDY QUESTION: What is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)? SUMMARY ANSWER: SHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular injury and increased baseline hypertension as well as placental insufficiency and asymmetric fetal growth restriction...
April 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28401733/effects-of-metals-cadmium-and-chromium-alone-and-in-combination-on-the-liver-and-kidney-tissue-of-male-spraque-dawley-rats-an-ultrastructural-and-electron-energy-loss-spectroscopy-investigation
#20
Chantelle Venter, Hester Magdalena Oberholzer, Franscious Riccardo Cummings, Megan Jean Bester
Heavy metal pollution has increased in the last decades. Water sources are contaminated and human exposure is often long term exposure to variable amounts of different metals. In this study, male Sprague-Dawley rats were exposed via oral gavage for 28 days to cadmium (Cd) and chromium (Cr), alone and in combination at concentrations 1000 times the human World Health Organization's acceptable water limits. Rat equivalent dosages were used. Blood markers of liver and kidney function were measured, changes to cellular morphology was determined with transmission electron microscopy and the intracellular metal localisation was determined with the electron energy-loss spectroscopy and energy filtered transmission electron microscopy analysis...
April 12, 2017: Microscopy Research and Technique
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