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preoperative evaluation pancreas surgery

Shinsuke Koshita, Yutaka Noda, Kei Ito, Yoshihide Kanno, Takahisa Ogawa, Kaori Masu, Yoshiharu Masaki, Jun Horaguchi, Masaya Oikawa, Takashi Tsuchiya, Takashi Sawai, Miwa Uzuki, Fumiyoshi Fujishima
BACKGROUND AND AIMS: To elucidate the efficacy of pancreatic juice cytology with the cell block method (CB-PJC) for the determination of surgery in patients with branch duct intraductal papillary mucinous neoplasm (BD-IPMN). METHODS: In 138 patients with BD-IPMN from whom pancreatic juice was collected under ERCP for CB-PJC, we retrospectively evaluated the following: (1) the rate of the CB-PJC successfully evaluated, (2) the ability of CB-PJC for the diagnosis of malignant BD-IPMNs and for the identification of pathological subtypes in resected BD-IPMNs, (3) the rate of development into invasive cancer and progression of BD-IPMNs in patients with BD-IPMN diagnosed as benignancy by CB-PJC, and (4) post-ERCP adverse events...
October 15, 2016: Gastrointestinal Endoscopy
Selma J Lekkerkerker, Marc G Besselink, Olivier R Busch, Joanne Verheij, Marc R Engelbrecht, Erik A Rauws, Paul Fockens, Jeanin E van Hooft
BACKGROUND AND AIMS: Currently, 3 guidelines are available for the management of pancreatic cysts. These guidelines vary in their indication for resection of high-risk cysts. We retrospectively compared the final pathological outcome of surgically removed pancreatic cysts with the indications for resection according to 3 different guidelines. METHODS: Patients who underwent pancreatic resection were extracted from our prospective pancreatic cyst database (2006-present)...
September 29, 2016: Gastrointestinal Endoscopy
Awad Shamali, Raymond McCrudden, Pradeep Bhandari, Fanny Shek, Emily Barnett, Adrian Bateman, Mohammed Abu Hilal
BACKGROUND: Pancreaticoduodenectomy (PD) is a complex procedure, associated with a definite risk of mortality and 30-50% risk of complications. For nonampullary duodenal lesions, PD can carry a higher morbidity as they are more commonly associated with a soft pancreas and narrow-calibre main pancreatic ducts. It is therefore paramount that the risks and benefits of surgery are considered carefully in this group of patients. A preoperative histological diagnosis for duodenal lesions is normally achieved by endoscopic biopsy...
September 3, 2016: European Journal of Gastroenterology & Hepatology
Seok Jeong Yang, Ho Kyoung Hwang, Chang Moo Kang, Woo Jung Lee
AIM: To provide appropriate treatment, it is crucial to share the clinical status of pancreas head cancer among multidisciplinary treatment members. METHODS: A retrospective analysis of the medical records of 113 patients who underwent surgery for pancreas head cancer from January 2008 to December 2012 was performed. We developed preoperative defining system of pancreatic head cancer by describing "resectability - tumor location - vascular relationship - adjacent organ involvement - preoperative CA19-9 (initial bilirubin level) - vascular anomaly"...
July 14, 2016: World Journal of Gastroenterology: WJG
L B Xiang, Y X Tu, T C He, X Pei, X X Shen, W T Yang, X H Wu, H J Yang
OBJECTIVE: The aim of this study is to evaluate the safety and efficacy of partial pancreatectomy as part of primary cytoreductive surgery in advanced epithelial ovarian cancer (EOC). METHODS: A total of 8 patients were recruited in this study who underwent partial pancreatectomy during the primary cytoreductive surgeries for advanced EOC in Fudan University Shanghai Cancer Center from April 2009 to July 2015. Their clinicopathological characteristics, diameter of metastatic tumors, the scope of cytoreductive surgeries, residual diseases after cytoreductive surgeries, postoperative complications and survival situation were retrospective analyzed...
May 25, 2016: Zhonghua Fu Chan Ke za Zhi
Toru Okuzono, Yoshihide Kanno, Hayato Aoki, Shun Sato, Tomoki Matsuda, Masato Nakahori, Akimichi Chonan
BACKGROUND AND AIM: Recent studies have reported usefulness of preoperative EUS-guided fiducial tattooing (EUS-tattooing) of the pancreas. However, issues of proper procedure, including markers and amounts, have not been resolved. The aim of the present study was to evaluate the feasibility of EUS-tattooing with a minuscule amount of marking solution utilizing the new injector METHODS: Six consecutive patients who underwent EUS-tattooing between June 2013 and April 2015 at our center were retrospectively analyzed (mean age, 60...
May 4, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Courtney J Balentine, Aanand D Naik, David H Berger, Herbert Chen, Daniel A Anaya, Gregory D Kennedy
IMPORTANCE: Advanced age is an important risk factor for discharge to postacute care (PAC) facilities including skilled nursing and rehabilitation. Factors modifying the age-related risk of discharge to PAC have not been adequately examined for surgical patients. OBJECTIVE: To evaluate how preoperative functional status and postoperative complications affect age-related risk of discharge to PAC facilities following major abdominal surgery. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study of 55 238 patients aged 18 years or older having colorectal, pancreas, or liver operations in 2011 and 2012 at hospitals participating in the National Surgical Quality Improvement Program...
August 1, 2016: JAMA Surgery
Nao Kobayashi, Hisashi Shinohara, Shusuke Haruta, Yu Ohkura, Aya Mizuno, Masaki Ueno, Harushi Udagawa, Yoshiharu Sakai
BACKGROUND: Postoperative pancreatic fistula (POPF)-often caused by pancreatic injury during dissection of the peripancreatic lymph nodes-is a serious complication after gastric cancer surgery. We defined protruding pancreatic tissue on the anterior side of the pancreas head as "process of the pancreas head" (PPH) and investigated whether PPH is a predictable risk factor for POPF after laparoscopic gastrectomy. METHODS: We reviewed 255 patients who underwent laparoscopic total or distal gastrectomy for gastric cancer...
September 2016: World Journal of Surgery
Kim C Honselmann, Tobias Krauss, Sebastian Geserick, Ulrich F Wellner, Uwe Wittel, Ulrich T Hopt, Tobias Keck, Dirk Bausch
PURPOSE: The purpose of this study was to retrospectively evaluate diagnostic accuracy of cystic lesions of the pancreas in order to determine if less aggressive surgical treatment might be safe and therefore warranted. METHODS: A retrospective cohort study was conducted in 232 patients with either observed or resected cystic lesions of the pancreas referred for evaluation and treatment to the University Medical Center Freiburg, Germany, between 2001 and 2011. RESULTS: Most patients had MRI or CT for preoperative imaging (90...
June 2016: Langenbeck's Archives of Surgery
Veysel Sal, Fuat Demirkiran, Samet Topuz, Ilker Kahramanoglu, Ibrahim Yalcin, Tugan Bese, Hamdullah Sozen, Nedim Tokgozoglu, Yavuz Salihoglu, Hasan Turan, Cem Iyibozkurt, Tugba Kolomuc, Nigar Sofiyeva, Sinan Berkman, Macit Arvas
OBJECTIVE: The purpose of this study was to investigate the outcomes and prognostic factors of metastasectomy in patients with metastatic ovarian tumors from extragenital primary sites. MATERIALS AND METHODS: All patients with pathologically confirmed metastatic ovarian tumors between January 1997 and June 2015 were included in this study. A total of 131 patients were identified. The data were obtained from the patients' medical records. Clinicopathological features were evaluated by both univariate and multivariate analyses...
May 2016: International Journal of Gynecological Cancer
Ming Wang, Ben-Yuan Deng, Tian-Fu Wen, Wei Peng, Chuan Li, Narasimha Murthy Trishul
BACKGROUND: Intraductal papillary mucinous neoplasms of the biliary tract (BT-IPMNs) are unique but very rare biliary tumors. The relationship between BT-IPMNs and intraductal papillary mucinous neoplasm of the pancreas (P-IPMNs) was still unclear and controversial. OBJECTIVE: We aimed to evaluate the clinical, radiological, histopathological, and prognostic characteristics of BT-IPMNs and P-IPMNs to achieve a better understanding of these two rare bilio-pancreatic diseases and their connections...
April 2016: Clinics and Research in Hepatology and Gastroenterology
Yoshiteru Katsura, Yutaka Takeda, Yoshiaki Ohmura, Yurina Motoyama, Tomo Ishida, Yoshihiro Morimoto, Katsunori Matsushita, Atsushi Naito, Kohei Murakami, Yoshinori Kagawa, Masatsugu Okishiro, Atsushi Takeno, Chiyomi Egawa, Takeshi Kato, Shigeyuki Tamura
Pancreatic ductal carcinoma is a highly aggressive cancer, with one of the highest mortality rates among gastrointestinal cancers. Nab-paclitaxel plus gemcitabine (GEM) significantly improved overall survival, progression-free survival, and response rate in a phase Ⅲ trial in 151 community and academic centers in 11 countries. As a result, nab-paclitaxel plus GEM was approved for use in December 2014 in Japan. We report a case of a patient with pancreatic cancer who underwent this chemotherapy. A 47-year-old man was admitted to our hospital for evaluation of pancreatic lesions...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Zijah Rifatbegovic, Zlatan Mehmedovic, Majda Mehmedovic, Jasmin Hasanovic, Amra Mestric
Background. The role of multivisceral resection, in the setting of locally advanced gastric cancer, is still debated. Previous studies have reported a higher risk for perioperative morbidity and mortality, with limited objective benefit in terms of survival. Patient. A male patient, 55 years old, was admitted to the clinic of surgery for surgical treatment of bleeding gastric ulceration. Preoperative diagnostic evaluation was performed, and patient had undergone a surgical treatment which revealed a large mass in head of the pancreas, infiltrating the hepatoduodenal ligament and transverse mesocolon...
2015: Case Reports in Surgery
Pascal Probst, Sebastian Haller, Colette Dörr-Harim, Thomas Bruckner, Alexis Ulrich, Thilo Hackert, Markus K Diener, Phillip Knebel
BACKGROUND: The influence of patients' preoperative nutritional status on their clinical outcome has already been proven. Therefore, patients with malnutrition are in need of additional therapeutic efforts. However, for pancreatic surgery, evidence suggesting the adequacy of existing nutritional assessment scores to estimate malnutrition associated with postoperative outcome is limited. OBJECTIVE: The aim of the observational trial "Nutritional Risk in Major Abdominal Surgery (NURIMAS) Pancreas" is to prospectively assess and analyze different nutritional assessment scores for their prognostic value on postoperative complications in patients undergoing pancreatic surgery...
2015: JMIR Research Protocols
Juhan Lee, Jin Hong Lim, Sung Hoon Kim, Hyun Ki Kim, Seung Woo Park, Jae Bock Chung, Kyung Sik Kim
BACKGROUNDS/AIMS: With development of imaging techniques, pancreatic tumors are being diagnosed more frequently. Applying the standard surgical procedures for pancreatic head tumors, such as pancreaticoduodenectomy and pylorus-preserving pancreaticoduodenectomy may seem too extensive for benign or low-grade malignant pancreas head tumors. Duodenum-preserving pancreatic head resection (DPPHR) has been safely performed in patients with chronic pancreatitis. Recently, DPPHR has been used as a limited surgical procedure to remove benign or low-grade malignant pancreatic head lesions...
August 2013: Korean Journal of Hepato-biliary-pancreatic Surgery
Kae Tanaka, Hiroyuki Harada, Kou Kayamori, Ken Omura
Immunoglobulin G4-related disease (IgG4-RD) is a systemic condition accompanied by tumefactive lesions, dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis in various organs, and, frequently, elevated serum IgG4 levels. Chronic sclerosing sialadenitis (also termed Küttner's tumor) is thought to be a lesion of IgG4-RD; thus, IgG4-related sialadenitis may be the initial symptom of IgG4-RD. We herein report a 64-year-old Japanese female with IgG4-related chronic sclerosing sialadenitis of the right submandibular gland and retroperitoneal fibrosis, who subsequently developed tubulointerstitial nephritis and pancreatitis...
2015: Tohoku Journal of Experimental Medicine
S E Voskanyan, K V Kotenko, I N Korsakov, E V Naydenov
RESEARCH OBJECTIVE: Study preoperative and intraoperative risk factors for acute postoperative pancreatitis after surgical treatment of the pancreatic diseases. MATERIAL AND METHODS: Predictive value of the probable preoperative and intraoperative risk factors of the acute postoperative pancreatitis after surgical treatment of the proximal and distal pancreatic cancer were explored and evaluated. Patients were divided at the high risk group and mild risk group using a specially developed formula...
2014: Experimental & Clinical Gastroenterology
Renping Huang, Bing Liu, Hua Chen, Xuewei Bai, Rui Kong, Gang Wang, Yongwei Wang, Bei Sun, Yinghui Guan
The study aimed to uncover the risk factors for the new defined pancreatic fistula (PF) and clinical related PF (CR-PF) after pancreaticoduodenectomy (PD) surgery and to evaluate the medico-economic effect of patients. A total of 412 patients were classified into two groups according to different criteria, PF and NOPF according to PF occurrence: CR-PF (grades B and C) and NOCR-PF (grade A) based on PF severity. A total of 28 factors were evaluated by univariate and multivariate logistic regression test. Hospital charges and stays of these patients were assessed...
2015: Gastroenterology Research and Practice
A Hubalewska-Dydejczyk, A Sowa-Staszczak, M Tomaszuk, A Stefańska
Glucagon-like peptide 1 (GLP-1) receptors expression has been found on many types of cancer cells. In case of benign insulinoma the density of those receptors is even higher than the density of somatostatin receptors. This article presents the results of clinical trials proving the utility of GLP-1 receptors imaging. Scintigraphy or positron emission tomography with the use of GLP-1 analogues labelled with appropriate radioisotopes (111In, 99mTc, 68Ga, 18F or 64Cu) seem to be superior compared with other available techniques in diagnosis of hardly detectable benign insulinoma...
June 2015: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Adam E Frampton, Justin Stebbing, Tamara M H Gall, Benjamin Silver, Long R Jiao, Jonathan Krell
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have a risk of malignant transformation following an adenoma-carcinoma sequence. Surgical resection is often required, especially for main pancreatic duct IPMNs (MD-IPMNs). There is an urgent need for novel biomarkers to reliably differentiate IPMNs from more benign pancreatic cysts and therefore avoid unnecessary surgery. DNA sequencing has demonstrated that guanine nucleotide binding protein alpha stimulating (GNAS) activity polypeptide 1 mutations play a driving role in IPMN development...
March 2015: Expert Review of Molecular Diagnostics
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