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Platelet reach plasma

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https://www.readbyqxmd.com/read/28214180/a-successful-experience-of-the-iranian-blood-transfusion-organization-in-improving-accessibility-and-affordability-of-plasma-derived-medicine
#1
REVIEW
Azita Chegini, Seyed Ardeshir Torab, Ali Akbar Pourfatollah
Plasma is the liquid part of blood. It is estimated 21.6 million liters of plasma collect from Whole blood annually. From these plasma, 4.2 million liters transfuse, 8.1 million liters fractionate, 9.3 million liters waste. Nowadays, blood products and PDM (plasma derived medicine) consider as essential medicine in modern health care and transfusion medicine. Iranian blood transfusion organization as a non-profit organization was established in 1974 in order to centralize all blood transfusion activities from donor recruitment to distribution of blood components to hospitals...
January 4, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28103989/-experimental-research-on-the-effects-of-different-activators-on-the-formation-of-platelet-rich-gel-and-the-release-of-bioactive-substances-in-human-platelet-rich-plasma
#2
Y Yang, W Zhang, B Cheng
Objective: To explore the effects of calcium gluconate and thrombin on the formation of platelet-rich gel (PRG) and the release of bioactive substances in human platelet-rich plasma (PRP) and the clinical significance. Methods: Six healthy blood donors who met the inclusion criteria were recruited in our unit from May to August in 2016. Platelet samples of each donor were collected for preparation of PRP. (1) PRP in the volume of 10 mL was collected from each donor and divided into thrombin activation group (TA, added with 0...
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28057550/pharmacokinetics-of-lbpt-and-its-primary-metabolites-as-well-as-tolerability-in-the-first-in-human-study
#3
Hongyun Wang, Hongzhong Liu, Ming Liu, Wenjie Wang, Liya Zhu, Haihong Huang, Pei Hu, Ji Jiang
BACKGROUND: LBPT is a novel platelet-activating factor (PAF) receptor antagonist that is developed for the treatment of rheumatoid arthritis. The purpose of this first-in-human study was to evaluate the tolerability and safety of LBPT, to investigate the pharmacokinetics of LBPT and its primary metabolites, as well as to assess the food effect on the pharmacokinetics in healthy Chinese subjects. MATERIALS AND METHODS: LBPT was evaluated in 2 clinical studies. The first study was a double blind, placebo-controlled and ascending dose study...
January 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28052313/thromboelastography-teg-or-rotational-thromboelastometry-rotem-to-monitor-haemostatic-treatment-in-bleeding-patients-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#4
REVIEW
A Wikkelsø, J Wetterslev, A M Møller, A Afshari
Coagulopathy and severe bleeding are associated with high mortality. We evaluated haemostatic treatment guided by the functional viscoelastic haemostatic assays, thromboelastography or rotational thromboelastometry in bleeding patients. We searched for randomised, controlled trials irrespective of publication status, publication date, blinding status, outcomes published or language from date of inception to 5 January 2016 in six bibliographic databases. We included 17 trials (1493 participants), most involving cardiac surgery...
January 4, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28005949/netosis-before-and-after-hyperglycemic-control-in-type-2-diabetes-mellitus-patients
#5
Agostina Carestia, Gustavo Frechtel, Gloria Cerrone, María A Linari, Claudio D Gonzalez, Patricia Casais, Mirta Schattner
INTRODUCTION AND OBJECTIVE: Diabetes is characterized by chronic inflammation, endothelial dysfunction, increased risk of infections and early cardiovascular disease. By releasing neutrophil extracellular traps (NETs), neutrophils kill bacteria and exert pro-inflammatory and pro-thrombotic activities. Increased NETosis has been found in cross-sectional studies including treated type 2 diabetes mellitus (T2DM) patients. In this study, we determined whether the ability of neutrophils to form NETs differs in diabetic patients pre- and post-hyperglycemic control versus healthy donors (HD), and the relationship between NETosis with pro-thrombotic, pro-inflammatory biomarkers and thrombotic clinical events...
2016: PloS One
https://www.readbyqxmd.com/read/27903394/-correlation-between-epicardial-adipose-tissue-thickness-and-slow-flow-of-non-obstructive-coronary-artery
#6
Q Wu, B Yang
Objective: To investigate the correlation between epicardial adipose thickness and slow flow of non-obstructive coronary artery. Methods: Clinical data of patients with coronary angiography examination evidenced stenosis<50% in our department from May 2014 to May 2015 were retrospectively analyzed.According to the level of TIMI in angiography, patients were divided into slow blood flow group (TIMI Ⅰ-Ⅱ, n=16) and normal blood flow group (TIMI Ⅲ, n=127). All epicardial adipose thickness was determined by echocardiography and data of biochemical data (fibrinogen, whole blood viscosity at high shear rate, erythrocyte aggregation index, platelet count, and platelet aggregation rate) were also analyzed...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27900152/depa-classification-a-proposal-for-standardising-prp-use-and-a-retrospective-application-of-available-devices
#7
J Magalon, A L Chateau, B Bertrand, M L Louis, A Silvestre, L Giraudo, J Veran, F Sabatier
BACKGROUND/AIM: Significant biological differences in platelet-rich plasma (PRP) preparations have been highlighted and could explain the large variability in the clinical benefit of PRP reported in the literature. The scientific community now recommends the use of classification for PRP injection; however, these classifications are focused on platelet and leucocyte concentrations. This presents the disadvantages of (1) not taking into account the final volume of the preparation; (2) omitting the presence of red blood cells in PRP and (3) not assessing the efficiency of production...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27827279/plasma-rich-in-growth-factors-promotes-dermal-fibroblast-proliferation-migration-and-biosynthetic-activity
#8
COMPARATIVE STUDY
E Anitua, A Pino, G Orive
OBJECTIVE: The use of plasma rich in growth factors (PRGF) has gained importance in many medical fields due to its regenerative potential. The aim of this study is to evaluate the effects of PRGF on primary skin fibroblasts assessing cell proliferation, migration and secretion of growth factors. The age of the patients from who PRGF was prepared was also studied to determine whether it influenced the outcomes. METHOD: Human dermal fibroblasts were isolated from three healthy volunteers...
November 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27785872/von-willebrand-disease-type-1-mutation-p-arg1379cys-and-the-variant-p-ala1377val-synergistically-determine-a-2m-phenotype-in-four-italian-patients
#9
M T Pagliari, L Baronciani, F Stufano, I Garcia-Oya, G Cozzi, F Franchi, F Peyvandi
INTRODUCTION: We characterized five patients affected with von Willebrand disease (VWD) carrying the p.Arg1379Cys mutation. One was diagnosed as VWD type 1 and four as type 2M. The 2M patients also have the variant p.Ala1377Val in cis with p.Arg1379Cys. AIM: To evaluate the role of p.Ala1377Val and p.Arg1379Cys von Willebrand factor (VWF) variants to explain patients' phenotype. METHODS: Conventional phenotype tests were used to evaluate patients' plasma and platelets...
November 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27785095/consumption-of-nattokinase-is-associated-with-reduced-blood-pressure-and-von-willebrand-factor-a-cardiovascular-risk-marker-results-from-a-randomized-double-blind-placebo-controlled-multicenter-north-american-clinical-trial
#10
Gitte S Jensen, Miki Lenninger, Michael P Ero, Kathleen F Benson
OBJECTIVE: The objective of this study is to evaluate the effects of consumption of nattokinase on hypertension in a North American hypertensive population with associated genetic, dietary, and lifestyle factors. This is in extension of, and contrast to, previous studies on Asian populations. MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled, parallel-arm clinical study was performed to evaluate nattokinase (NSK-SD), a fermented soy extract nattō from which vitamin K2 has been removed...
2016: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/27714019/continuous-plasma-extraction-under-viscoelastic-fluid-in-a-straight-channel-with-asymmetrical-expansion-contraction-cavity-arrays
#11
Dan Yuan, Jun Zhang, Ronald Sluyter, Qianbin Zhao, Sheng Yan, Gursel Alici, Weihua Li
In this paper, continuous plasma extraction under viscoelastic fluid in a straight channel with asymmetrical expansion-contraction cavity arrays (ECCA channel) is demonstrated by exploiting the Dean-flow-coupled elasto-inertial effects. First, the forces experienced by particles in the ECCA channel were discussed. Then, 4.8 μm diameter particles, which mimic the behaviour of red blood cells (RBCs), were used to study the effects of poly(ethylene oxide) (PEO) concentrations and flow rates on particle viscoelastic focusing...
October 5, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27712038/evaluation-of-an-oral-direct-factor-xa-inhibitor-anticoagulant-in-healthy-adult-horses
#12
Maria L Rodríguez-Pozo, Lara Armengou, Luis Monreal, Judit Viu, Carla Cesarini, Eduard Jose-Cunilleras
OBJECTIVE: To assess whether an oral direct factor Xa inhibitor (DiXaI) anticoagulant drug used at the low end of the recommended dose in people achieves presumed prophylactic plasma concentrations and does not induce bleeding in horses. DESIGN: Experimental study. SETTING: Field study. ANIMALS: Ten healthy adult horses. INTERVENTIONS: A DiXaI was administered at a dose of 0.125 mg/kg every 24 h orally for 4 days...
January 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27604193/effect-of-intralesional-platelet-rich-plasma-prp-treatment-on-clinical-and-ultrasonographic-parameters-in-equine-naturally-occurring-superficial-digital-flexor-tendinopathies-a-randomized-prospective-controlled-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Florian Geburek, Moritz Gaus, Hans T M van Schie, Karl Rohn, Peter M Stadler
BACKGROUND: Regenerative and anti-inflammatory effects on tendinopathies have been attributed to blood-derived biologicals. To date the evidence for the efficacy of autologous platelet-rich plasma (PRP) treatment of naturally occurring equine tendinopathies is limited. The purpose of this placebo-controlled clinical trial was to describe the effect of a single treatment of equine superficial digital flexor tendon (SDFT) disease with PRP on clinical and ultrasonographic parameters. Twenty horses with naturally occurring tendinopathies of forelimb SDFTs were randomly assigned to the PRP-treated group (n = 10) or control group (n = 10) after clinical and ultrasonographic examination...
September 7, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27552162/thromboelastography-teg-or-thromboelastometry-rotem-to-monitor-haemostatic-treatment-versus-usual-care-in-adults-or-children-with-bleeding
#14
REVIEW
Anne Wikkelsø, Jørn Wetterslev, Ann Merete Møller, Arash Afshari
BACKGROUND: Severe bleeding and coagulopathy are serious clinical conditions that are associated with high mortality. Thromboelastography (TEG) and thromboelastometry (ROTEM) are increasingly used to guide transfusion strategy but their roles remain disputed. This review was first published in 2011 and updated in January 2016. OBJECTIVES: We assessed the benefits and harms of thromboelastography (TEG)-guided or thromboelastometry (ROTEM)-guided transfusion in adults and children with bleeding...
August 22, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27514617/the-pharmacokinetics-and-pharmacodynamics-of-prasugrel-and-clopidogrel-in-healthy-japanese-volunteers
#15
Kazuo Umemura, Takayuki Iwaki
The dosing regimen of prasugrel adjusted for Japanese patients was compared with that of clopidogrel by analyzing the pharmacokinetics and pharmacodynamics in 40 healthy Japanese subjects in a randomized, single-blind crossover study. In period 1, the subjects received either 300 mg clopidogrel or 20 mg prasugrel; after a >2-week interval (period 2), the drug was switched. Blood samples of 36 of the 40 subjects were collected for analysis of pharmacokinetics, pharmacodynamics, and CYP2C19 genotypes. The plasma concentration of the active metabolite of prasugrel increased rapidly and reached its peak 30 minutes postadministration, whereas that of the active metabolite of clopidogrel reached its peak 1 hour postadministration...
November 2016: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/27474356/pharmacokinetics-and-pharmacodynamics-of-prasugrel-in-healthy-japanese-subjects
#16
Kazuo Umemura, Yasuhiko Ikeda, Kazunao Kondo
This randomized double-blind and placebo-controlled study assessed the pharmacodynamics and pharmacokinetics of prasugrel in healthy adult Japanese male subjects after single (n = 50) and multiple (n = 40) oral administration. With a single administration of prasugrel (2-30 mg), the plasma concentration of the active metabolite increased rapidly, reached a maximum at 30 min after administration, and then decreased rapidly within 4 h. The 5 mg and higher doses prevented ADP-induced platelet aggregation in a dose-dependent manner...
August 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27389129/bundles-of-care-for-resuscitation-from-hemorrhagic-shock-and-severe-brain-injury-in-trauma-patients-translating-knowledge-into-practice
#17
Shahid Shafi, Ashley W Collinsworth, Kathleen M Richter, Hasan B Alam, Lance B Becker, Malcolm R Bullock, James M Ecklund, John Gallagher, Raj Gandhi, Elliott R Haut, Zachary L Hickman, Heidi Hotz, James McCarthy, Alex B Valadka, John Weigelt, John B Holcomb
No abstract text is available yet for this article.
October 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27227987/aaos-research-symposium-updates-and-consensus-biologic-treatment-of-orthopaedic-injuries
#18
Robert F LaPrade, Jason L Dragoo, Jason L Koh, Iain R Murray, Andrew G Geeslin, Constance R Chu
Strategies that seek to enhance musculoskeletal tissue regeneration and repair by modulating the biologic microenvironment at the site of injury have considerable therapeutic potential. Current and emerging biologic approaches include the use of growth factors, platelet-rich plasma, stem cell therapy, and scaffolds. The American Academy of Orthopaedic Surgeons hosted a research symposium in November 2015 to review the current state-of-the-art biologic treatments of articular cartilage, muscle, tendon, and bone injuries and identify knowledge gaps related to these emerging treatments...
July 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27196808/long-term-intra-aortic-balloon-pump-support-as-bridge-to-left-ventricular-assist-device-implantation
#19
Dimitrios Koudoumas, Konstantinos Malliaras, Stergios Theodoropoulos, Elisabeth Kaldara, Chris Kapelios, John Nanas
BACKGROUND: The intra-aortic balloon pump (IABP) can be used to bridge critically ill end-stage heart failure patients to left ventricular assist device (LVAD) implantation. However, the IABP's potential association with hemorrhagic complications raises concerns regarding its utilization in these patients. AIM: We investigated whether preoperative long-term IABP support increases hemorrhagic complications post-LVAD implantation. METHODS: Ten patients undergoing IABP support prior to LVAD implantation (IABP-LVAD group) were compared with 16 who did not require IABP support (LVAD group)...
July 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27188338/efficacy-and-safety-of-rituximab-in-japanese-patients-with-acquired-thrombotic-thrombocytopenic-purpura-refractory-to-conventional-therapy
#20
Yoshitaka Miyakawa, Kazunori Imada, Tatsuo Ichinohe, Kenji Nishio, Takayuki Abe, Mitsuru Murata, Yasunori Ueda, Yoshihiro Fujimura, Masanori Matsumoto, Shinichiro Okamoto
Thrombotic thrombocytopenic purpura (TTP), while rare, is a potentially life-threatening disorder. Plasma exchange (PE) is considered the primary treatment for TTP. In Western countries, rituximab, an anti-CD20 antibody, is recommended with PE for the treatment of refractory/relapsed TTP, and as up-front therapy in newly diagnosed TTP with neurological/cardiac pathology. The present open-label, single-arm, multicenter study evaluated the efficacy and safety of rituximab in Japanese patients with refractory/relapsed TTP...
August 2016: International Journal of Hematology
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