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Graves' disease

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https://www.readbyqxmd.com/read/29340156/hepatotoxicity-in-hyperthyroid-patient-after-consecutive-methimazole-and-propylthiouracil-therapies
#1
Fernando Gomez-Peralta, Pablo Velasco-Martínez, Cristina Abreu, María Cepeda, Marta Fernández-Puente
Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history diagnosed with hyperthyroidism due to Graves' disease, who developed two episodes of acute hepatitis concurrent with the consecutive administration of two different ATDs, first MMI and then PTU...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29336230/alterations-of-global-dna-methylation-and-dnmt-expression-in-t-and-b-lymphocytes-from-patients-with-newly-diagnosed-aitd-after-treatment-a-follow-up-study
#2
Qingling Guo, Dan Wu, Huixin Yu, Jiandong Bao, Shiqiao Peng, Zhongyan Shan, Haixia Guan, Weiping Teng
BACKGROUND: Dysregulated DNA methylation in lymphocytes has been linked to autoimmune disorders. The aims of this study were to identify global DNA methylation patterns in patients with autoimmune thyroid diseases (AITDs) and to observe methylation changes after treatment for these conditions. METHODS: We conducted a cross-sectional study design including the following patients: 51 with newly diagnosed Graves' disease (GD), 28 with autoimmune hypothyroidism (AIT), 29 with positive thyroid autoantibodies (pTAb) and 39 matched healthy volunteers...
January 16, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29336220/serum-high-cholesterol-is-a-novel-risk-factor-for-graves-orbitopathy-go-results-of-a-cross-sectional-study
#3
Elena Sabini, Barbara Mazzi, Maria Antonietta Profilo, Teresa Mautone, Giamberto Casini, Roberto Rocchi, Ilaria Ionni, Francesca Menconi, Marenza Leo, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marino
Background Limited data suggest that treatment with statins is associated with a reduced risk of Graves' orbitopathy (GO) in patients with Graves' disease (GD), attributed to the anti-inflammatory rather than to the hypolipemic effects of these medications. The aim of the present study was to investigate whether there is an association between high cholesterol and GO. The primary outcome was the relation between GO and low-density lipoprotein (LDL)-cholesterol. The secondary outcomes were the relation between severity or activity [the clinical activity score (CAS)] of GO and LDL-cholesterol...
January 16, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29334744/-selenium-treatment-in-thyreopathies
#4
Štefan Sotak
Selenium (latin Selenium) is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet and geographic area. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. The literature suggests that selenium supplementation of patients with Hashimotos thyroiditis is associated with a reduction in antithyroperoxidase antibody levels...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29334503/family-history-of-autoimmune-diseases-and-risk-of-gastric-cancer-a-national-cohort-study
#5
Jianguang Ji, Jan Sundquist, Kristina Sundquist
A personal history of autoimmune diseases is associated with an increased incidence of gastric cancer, but whether they share familial susceptibility is still unknown. The contribution of shared environmental or genetic factors toward the observed familial aggregation has not been determined. We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the familial risk of gastric cancer among individuals with a family history of a set of autoimmune diseases...
January 12, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29329570/exophthalmos-in-a-young-woman-with-no-graves-disease-a-case-report-of-igg4-related-orbitopathy
#6
Annamaria Erdei, Zita Steiber, Csaba Molnar, Ervin Berenyi, Endre V Nagy
BACKGROUND: Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy, orbital inflammation and pain which may mimic ophthalmic Graves' disease. CASE PRESENTATION: A 25-year-old woman has been referred to the endocrinology clinic, 4 months after delivery, with suspected Graves' orbitopathy...
January 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29325864/infections-genetic-and-environmental-factors-in-pathogenesis-of-autoimmune-thyroid-diseases
#7
REVIEW
Sanjeev Kumar Shukla, Govind Singh, Shahzad Ahmad, Prabhat Pant
In Autoimmune disease a combination of infection, genetic and environmental factors causes an autoimmune response to the thyroid gland (characterized by lymphocytic infiltrations), thyroid stimulating hormone receptor (TSHR) and different thyroid antigens. Graves' and Hashimoto disease are autoimmune disorders with genetic predisposition. CD40 that stimulates the proliferation and differentiation of lymphocytes is an essential immunomodulatory component for follicular cells in the thyroid and the cell that present the antigen...
January 8, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29325833/treatment-of-graves-disease-in-children-the-portuguese-experience
#8
Olinda Marques, Ana Antunes, Maria João Oliveira
INTRODUCTION: Graves' disease (GD) is an autoimmune thyroid disease, common in adults but rare in children. The best therapeutic approach remains controversial. OBJECTIVES: To ascertain the current treatment of pediatric GD in Portugal and to assess the clinical and biochemical factors that determine definitive/long-term remission after treatment with antithyroid drugs (ATDs). PATIENTS AND METHODS: A retrospective analysis of data about pediatric GD treatment collected from a nationwide survey conducted by the Portuguese Society of Pediatric Endocrinology and Diabetology from May to August 2013...
January 8, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29325496/maternal-thyrotropin-receptor-antibody-concentration-and-the-risk-of-fetal-and-neonatal-thyrotoxicosis-a-systematic-review
#9
Myrthe Marguerite van Dijk, Iris Smits, Eric Fliers, Peter H Bisschop
BACKGROUND: In pregnant women with Graves' disease, maternal thyrotropin receptor antibodies (TRAb) can cross the placenta and induce fetal or neonatal thyrotoxicosis. Symptoms of fetal thyrotoxicosis are tachycardia, intrauterine growth restriction and intra-uterine death. Recommendations on an upper limit of TRAb concentrations below which intensive fetal monitoring can be safely omitted vary between different guidelines. The objective of this study was to define an evidence-based cut-off level for maternal TRAb necessitating additional fetal monitoring during pregnancy...
January 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29324050/the-roles-of-adjuvant-supplements-in-colorectal-cancer-patients-on-chemotherapy-reaping-benefits-from-metabolic-crosstalk
#10
Babak Golkhalkhali, Audra Shaleena Paliany, Kin Fah Chin, Retnagowri Rajandram
The prevalence of colorectal cancer (CRC) is on a steady rise over the years, with the World Health Organization (WHO) reporting CRC as the fourth leading cause of cancer-related death worldwide. While treatment modalities may differ in accordance to the staging and severity of the disease itself, chemotherapy is almost unavoidable in most cases. Though effective in its mode of action, chemotherapy is commonly associated with undesirable side effects that negatively affects the patient in terms of quality of life, and in some cases may actually interfere with their treatment regimens, thus escalating to poor prognosis...
January 11, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29322726/thrombocytopenia-as-harbinger-of-graves-disease-a-rare-presentation
#11
Rudrajit Paul, Rathindranath Sarkar, Debaditya Roy, Indranil Thakur, Gautam Lahiri, Tanmay Jyoti Sau, Ratul Ghosh
No abstract text is available yet for this article.
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29319400/deep-lateral-wall-orbital-decompression-following-strabismus-surgery-in-patients-with-type-ii-ophthalmic-graves-disease
#12
Michael P Ellis, Emily C Broxterman, Alan R Hromas, Thomas J Whittaker, Jason A Sokol
PURPOSE: Surgical management of ophthalmic Graves' disease traditionally involves, in order, orbital decompression, followed by strabismus surgery and eyelid surgery. Nunery et al. previously described two distinct sub-types of patients with ophthalmic Graves' disease; Type I patients exhibit no restrictive myopathy (no diplopia) as opposed to Type II patients who do exhibit restrictive myopathy (diplopia) and are far more likely to develop new-onset worsening diplopia following medial wall and floor decompression...
January 10, 2018: Orbit
https://www.readbyqxmd.com/read/29319381/novel-use-of-non-echo-planar-diffusion-weighted-mri-in-monitoring-disease-activity-and-treatment-response-in-active-grave-s-orbitopathy-an-initial-observational-cohort-study
#13
Ravi Kumar Lingam, Pravin Mundada, Vickie Lee
AIM: To examine the novel use of non-echo-planar diffusion weighted MRI (DWI) in depicting activity and treatment response in active Grave's orbitopathy (GO) by assessing, with inter-observer agreement, for a correlation between its apparent diffusion coefficients (ADCs) and conventional Short tau Inversion Recovery (STIR) MRI signal-intensity ratios (SIRs). METHOD AND MATERIALS: A total of 23 actively inflamed muscles and 30 muscle response episodes were analysed in patients with active GO who underwent medical treatment...
January 10, 2018: Orbit
https://www.readbyqxmd.com/read/29319139/the-role-of-99mtc-dtpa-retrobulbar-spect-in-staging-and-follow-up-of-graves-orbitopathy
#14
László Galuska, Sándor Barna, József Varga, Ildikó Garai, Endre V Nagy
The pathogenesis of Graves' orbitopathy (GO) is not completely understood. Coexistent hyperfunction of the thyroid gland is frequent; however, GO may also coexist with hypo- or euthyrodism. The course of GO is largely independent of thyroid function, although elevated serum TSH is known to negatively interfere with GO course. GO is severe in 10 % of the cases; sight threatening complications may also develop. A successful therapy of GO requires the assesment of both the severity and activity of orbital inflammation...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29319128/the-preliminary-study-on-expression-and-clinical-value-of-platelet-derived-growth-factor-bb-hypoxia-inducible-factor-1%C3%AE-and-c-c-motif-chemokine-receptor-2-in-the-peripheral-blood-during-the-pathogenesis-of-graves-disease
#15
Ying Liu, Jinglan Tang, Qiaohong Hu, Kefeng Lu, Chunjie Hou
Backgroud: Platelet-derived growth factor BB (PDGF-BB) plays an important role in the development of GD(Graves' disease). However, it is still unknown whether PDGF-BB is expressed in peripheral blood and whether the expression of PDGF-BB contributes to GD. We aim to study the expression of PDGF-BB, Hypoxia inducible factor(HIF)-1α and C-C motif chemokine receptor(CCR)-2 in peripheral blood of patients with GD and explore its effect and potential mechanism in pathogenesis. METHODS: 41 patients with GD (GD group) and 45 healthy people(control group) were chosen...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29310665/a-patient-specific-treatment-model-for-graves-hyperthyroidism
#16
Balamurugan Pandiyan, Stephen J Merrill, Flavia Di Bari, Alessandro Antonelli, Salvatore Benvenga
BACKGROUND: Graves' is disease an autoimmune disorder of the thyroid gland caused by circulating anti-thyroid receptor antibodies (TRAb) in the serum. TRAb mimics the action of thyroid stimulating hormone (TSH) and stimulates the thyroid hormone receptor (TSHR), which results in hyperthyroidism (overactive thyroid gland) and goiter. Methimazole (MMI) is used for hyperthyroidism treatment for patients with Graves' disease. METHODS: We have developed a model using a system of ordinary differential equations for hyperthyroidism treatment with MMI...
January 9, 2018: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29310490/harnessing-electronic-medical-records-to-advance-research-on-multiple-sclerosis
#17
Vincent Damotte, Antoine Lizée, Matthew Tremblay, Alisha Agrawal, Pouya Khankhanian, Adam Santaniello, Refujia Gomez, Robin Lincoln, Wendy Tang, Tiffany Chen, Nelson Lee, Pablo Villoslada, Jill A Hollenbach, Carolyn D Bevan, Jennifer Graves, Riley Bove, Douglas S Goodin, Ari J Green, Sergio E Baranzini, Bruce Ac Cree, Roland G Henry, Stephen L Hauser, Jeffrey M Gelfand, Pierre-Antoine Gourraud
BACKGROUND: Electronic medical records (EMR) data are increasingly used in research, but no studies have yet evaluated similarity between EMR and research-quality data and between characteristics of an EMR multiple sclerosis (MS) population and known natural MS history. OBJECTIVES: To (1) identify MS patients in an EMR system and extract clinical data, (2) compare EMR-extracted data with gold-standard research data, and (3) compare EMR MS population characteristics to expected MS natural history...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29310374/horner-syndrome-as-a-postoperative-complication-after-minimally-invasive-video-assisted-thyroidectomy-a-case-report
#18
Xiaolei Hu, Xiaomei Zhang, Huaiyong Gan, Dajun Yu, Weihua Sun, Zhaoming Shi
RATIONALE: Horner syndrome is an unusual complication after thyroidectomy. PATIENT CONCERNS: We report a case of Horner syndrome in a 34-year-old female patient with Graves disease associated with papillary thyroid carcinoma who underwent left-side minimally invasive video-assisted thyroidectomy and neck dissection. DIAGNOSIS: Horner syndrome was diagnosed based on left myosis, eyelid ptosis, and mild enophthalmos, which developed in the patient on postoperative day 2...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29306930/management-of-thyrotoxicosis-in-children-and-adolescents-35-years-experience-in-304-patients
#19
Fereidoun Azizi, Atieh Amouzegar
BACKGROUND: Diffuse toxic goiter accounts for about 15% of all childhood thyroid diseases. There is great controversy over the management of Graves' disease in children and adolescents. This article reports our experience in 304 children and juvenile patients with Graves' disease. METHODS: Between 1981 and 2015, 304 patients aged 5-19 years with diffuse toxic goiter were studied, of whom 296 patients were treated with antithyroid drugs (ATD) for 18 months. Patients with persistent or relapsed hyperthyroidism who refused ablative therapy with surgery or radioiodine were managed with continuous methimazole (MMI) treatment...
January 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29306805/changes-in-mycelia-growth-sporulation-and-virulence-of-phytophthora-capsici-when-challenged-by-heavy-metals-cu2-cr2-and-hg2-under%C3%A2-acid-ph-stress
#20
Peiqing Liu, Mengyao Wei, Jinzhu Zhang, Rongbo Wang, Benjin Li, Qinghe Chen, Qiyong Weng
Phytophthora capsici, an economically devastating oomycete pathogen, causes devastating disease epidemics on a wide range of vegetable plants and pose a grave threat to global vegetables production. Heavy metals and acid pH are newly co-occurring stresses to soil micro-organisms, but what can be expected for mycelia growth and virulence and how they injure the oomycetes (especially P. capsici) remains unknown. Here, the effects of different heavy metals (Cu2+, Cr2+, and Hg2+) on mycelia growth and virulence were investigated at different pHs (4...
January 4, 2018: Environmental Pollution
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