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zika dengue chikungunya

Amelia R I Lindsey, Tamanash Bhattacharya, Irene L G Newton, Richard W Hardy
At the forefront of vector control efforts are strategies that leverage host-microbe associations to reduce vectorial capacity. The most promising of these efforts employs Wolbachia , a maternally transmitted endosymbiotic bacterium naturally found in 40% of insects. Wolbachia can spread through a population of insects while simultaneously inhibiting the replication of viruses within its host. Despite successes in using Wolbachia -transfected mosquitoes to limit dengue, Zika, and chikungunya transmission, the mechanisms behind pathogen-blocking have not been fully characterized...
March 21, 2018: Viruses
Gouri Chaubal, Prasad Sarkale, Pravin Kore, Pragya Yadav
Background: Kyasanur Forest Disease (KFD), a tick borne flavivirus, which was earlier endemic to Karnataka state, India, has been confirmed and detected from neighboring states of Tamil Nadu, Maharashtra, Goa and Kerala states in India. Increased human and vector surveillance therefore becomes essential for the identification of KFD affected regions and control of further spread of the disease. Currently, available KFD detection assays include realtime RT-PCR and nested RT-PCR assays...
February 2018: Heliyon
Nadège Hamon, Malika Kaci, Jean-Pierre Uttaro, Christian Périgaud, Christophe Mathé
The synthesis and the antiviral evaluation of 3'-halo (iodo and fluoro) 5'-norcarbocyclic nucleoside phosphonates is described. No antiviral activity was observed against Zika virus, Dengue virus 2, HSV-1, HSV-2 and Chikungunya virus. In contrast, some of the synthesized compounds are potent inhibitors of the replication of HIV-1, comparatively to (R)-PMPA, with no concomitant cytotoxicity.
March 14, 2018: European Journal of Medicinal Chemistry
Jeffrey R Powell
Although numerous viruses are transmitted by mosquitoes, four have caused the most human suffering over the centuries and continuing today. These are the viruses causing yellow fever, dengue, chikungunya, and Zika fevers. Africa is clearly the ancestral home of yellow fever, chikungunya, and Zika viruses and likely the dengue virus. Several species of mosquitoes, primarily in the genus Aedes , have been transmitting these viruses and their direct ancestors among African primates for millennia allowing for coadaptation among viruses, mosquitoes, and primates...
March 19, 2018: American Journal of Tropical Medicine and Hygiene
Sagar B Kudchodkar, Hyeree Choi, Emma L Reuschel, Rianne Esquivel, Jackie Jin-Ah Kwon, Moonsup Jeong, Joel N Maslow, Charles C Reed, Scott White, J Joseph Kim, Gary P Kobinger, Pablo Tebas, David B Weiner, Kar Muthumani
Vaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and in some cases, effectively eradicated through the deployment of specific vaccines. However, efforts to develop effective vaccines against infectious pathogens such as influenza, HIV, dengue virus (DENV), chikungunya virus (CHIKV), Ebola virus, and Zika virus (ZIKV) have proven challenging. Zika virus is a mosquito-vectored flavivirus responsible for periodic outbreaks of disease in Africa, Southeast Asia, and the Pacific Islands dating back over 50 years...
March 16, 2018: Microbes and Infection
Huai Guan, Maoying Wang, Chenghong Liao, Jing Liang, Prajwalini Mehere, Meiling Tian, Hairong Liu, Howard Robinson, Jianyong Li, Qian Han
Mosquitoes transmit a number of diseases in animals and humans, including Dengue, Chikungunya and Zika viruses that affect millions of people each year. Controlling the disease-transmitting mosquitoes has proven to be a successful strategy to reduce the viruses transmission. Polyamines are required for the life cycle of the RNA viruses, Chikungunya virus and Zika virus, and a depletion of spermidine and spermine in the host via induction of spermine N-acetyltransferase restricts their replication. Spermine N-acetyltransferase is a key catabolic enzyme in the polyamine pathway, however there is no information of the enzyme identification in any insects...
2018: PloS One
Juliana Miron Vani, Maria Tereza Ferreira Duenhas Monreal, Sarah Alves Auharek, Andréa Luiza Cunha-Laura, Eduardo José de Arruda, Alessandra Ramos Lima, Cicera Maria da Silva, Andréia Conceição Milan Brochado Antoniolli-Silva, Dênis Pires de Lima, Adilson Beatriz, Rodrigo Juliano Oliveira
Dengue fever, chikungunya fever and Zika virus are epidemics in Brazil that are transmitted by mosquitoes, such as Aedes aegypti or Aedes albopictus. The liquid from shells of cashew nuts is attractive for its important biological and therapeutic activities, which include toxicity to mosquitoes of the genus Aedes. The present study evaluated the effects of a mixture of surfactants from natural cashew nutshell liquid and castor oil (named TaLCC-20) on the mortality of larvae and on the reproductive performance, embryonic and fetal development and genetic stability of Swiss mice...
2018: PloS One
José V J Silva, Thaísa R R Lopes, Edmilson F de Oliveira-Filho, Renato A S Oliveira, Ricardo Durães-Carvalho, Laura H V G Gil
Emerging and re-emerging viral infections transmitted by insect vectors (arthopode-borne viruses, arbovirus) are a serious threat to global public health. Among them, yellow fever (YFV), dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses are particularly important in tropical and subtropical regions. Although vector control is one of the most used prophylactic measures against arboviruses, it often faces obstacles, such as vector diversity, uncontrolled urbanization and increasing resistance to insecticides...
March 15, 2018: Acta Tropica
Luiz Guilherme Darrigo, Alexandre Machado de Sant'Anna Carvalho, Clarisse Martins Machado
PURPOSE OF REVIEW: Describe the characteristics of chikungunya, dengue, and Zika in transplant recipients and immunocompromised hosts. RECENT FINDINGS: Stem cell/bone marrow grafts, organs, and blood transfusions can transmit CHIKV/DENV/ZIKV infections, which are clinically similar, resembling influenza-like illness. Laboratory confirmation is necessary. In the acute phase, RT-PCR is preferred. DENV and ZIKV serology may cross-react. Delayed engraftment and extended viruria is observed in ZIKV+/HSCT recipients, while longer viremia is observed in DENV+/HSCT patients...
March 17, 2018: Current Infectious Disease Reports
Martha Zakrzewski, Gordana Rašić, Jonathan Darbro, Lutz Krause, Yee S Poo, Igor Filipović, Rhys Parry, Sassan Asgari, Greg Devine, Andreas Suhrbier
Medically important arboviruses such as dengue, Zika, and chikungunya viruses are primarily transmitted by the globally distributed mosquito Aedes aegypti. Increasing evidence suggests that transmission can be influenced by mosquito viromes. Herein RNA-Seq was used to characterize RNA metaviromes of wild-caught Ae. aegypti from Bangkok (Thailand) and from Cairns (Australia). The two mosquito populations showed a high degree of similarity in their viromes. BLAST searches of assembled contigs suggest up to 27 insect-specific viruses may infect Ae...
March 16, 2018: Scientific Reports
Daniel Barros de Castro, Vanderson Souza Sampaio, Bernardino Cláudio de Albuquerque, Rosemary Costa Pinto, Megumi Sadahiro, Ricardo Augusto Dos Passos, Cristiano Fernandes da Costa, José Ueleres Braga
BACKGROUND: Dengue is the most prevalent arboviral disease affecting humans. The frequency and magnitude of dengue epidemic have significantly increased over recent decades. This study aimed to identify dengue epidemic types and risk factors for the extensive epidemics that occurred in 2010-2011, across the municipalities of Amazonas state, Brazil. METHODS: Using an ecological approach, secondary data were obtained from the dengue fever surveillance system. Epidemic waves were classified according to three indices: duration, intensity, and coverage...
March 15, 2018: BMC Public Health
Donal Bisanzio, Felipe Dzul-Manzanilla, Hector Gomez-Dantés, Norma Pavia-Ruz, Thomas J Hladish, Audrey Lenhart, Jorge Palacio-Vargas, Jesus F González Roldan, Fabian Correa-Morales, Gustavo Sánchez-Tejeda, Pablo Kuri Morales, Pablo Manrique-Saide, Ira M Longini, M Elizabeth Halloran, Gonzalo M Vazquez-Prokopec
Response to Zika virus (ZIKV) invasion in Brazil lagged a year from its estimated February 2014 introduction, and was triggered by the occurrence of severe congenital malformations. Dengue (DENV) and chikungunya (CHIKV) invasions tend to show similar response lags. We analyzed geo-coded symptomatic case reports from the city of Merida, Mexico, with the goal of assessing the utility of historical DENV data to infer CHIKV and ZIKV introduction and propagation. About 42% of the 40,028 DENV cases reported during 2008-2015 clustered in 27% of the city, and these clustering areas were where the first CHIKV and ZIKV cases were reported in 2015 and 2016, respectively...
March 15, 2018: PLoS Neglected Tropical Diseases
Azael Che-Mendoza, Anuar Medina-Barreiro, Edgar Koyoc-Cardeña, Valentín Uc-Puc, Yamili Contreras-Perera, Josué Herrera-Bojórquez, Felipe Dzul-Manzanilla, Fabian Correa-Morales, Hilary Ranson, Audrey Lenhart, Philip J McCall, Axel Kroeger, Gonzalo Vazquez-Prokopec, Pablo Manrique-Saide
BACKGROUND: There is a need for effective methods to control Aedes aegypti and prevent the transmission of dengue, chikungunya, yellow fever and Zika viruses. Insecticide treated screening (ITS) is a promising approach, particularly as it targets adult mosquitoes to reduce human-mosquito contact. METHODOLOGY/PRINCIPAL FINDINGS: A cluster-randomised controlled trial evaluated the entomological efficacy of ITS based intervention, which consisted of the installation of pyrethroid-impregnated long-lasting insecticide-treated netting material fixed as framed screens on external doors and windows...
March 15, 2018: PLoS Neglected Tropical Diseases
José Sánchez-Carbonel, Derek Tantaléan-Yépez, Miguel Angel Aguilar-Luis, Wilmer Silva-Caso, Pablo Weilg, Fernando Vásquez-Achaya, Luis Costa, Johanna Martins-Luna, Isabel Sandoval, Juana Del Valle-Mendoza
OBJECTIVE: To assess the presence of Dengue, Chikungunya, and Zika in serum samples of patients with acute febrile illness in Piura, Peru and describe the most common clinical features. RESULTS: Dengue was the most common arbovirus detected in 170/496 (34.3%), followed by Zika in 39/496 (7.9%) and Chikungunya in 23/496 (4.6%). Among the 170 samples positive for Dengue, serotype 2 was the most predominant type present in 97/170 (57.1%) of samples, followed by the serotype 3 in 9/170 (5...
March 14, 2018: BMC Research Notes
Imelda Menchaca-Armenta, Moisés Ocampo-Torres, Arnulfo Hernández-Gómez, Karen Zamora-Cerritos
Diseases caused by viruses such as dengue, chikungunya and zika are mosquito-borne diseases transmitted by Aedes aegypti. We performed a cross-sectional study of healthcare personnel and the general population using questionnaires to identify the level of knowledge, attitudes and practices, and risk perception for dengue, chikungunya and zika. A total of 248 questionnaires were applied, 63.3% to healthcare personnel and 36.7% to the general population. Of the healthcare personnel, 53% were men, and in the general population 74% were women...
March 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
Yanouk Epelboin, Sarah C Chaney, Amandine Guidez, Nausicaa Habchi-Hanriot, Stanislas Talaga, Lanjiao Wang, Isabelle Dusfour
Since the 1940s, French Guiana has implemented vector control to contain or eliminate malaria, yellow fever, and, recently, dengue, chikungunya, and Zika. Over time, strategies have evolved depending on the location, efficacy of the methods, development of insecticide resistance, and advances in vector control techniques. This review summarises the history of vector control in French Guiana by reporting the records found in the private archives of the Institute Pasteur in French Guiana and those accessible in libraries worldwide...
March 12, 2018: Memórias do Instituto Oswaldo Cruz
C Talero-Gutiérrez, A Rivera-Molina, C Pérez-Pavajeau, I Ossa-Ospina, C Santos-García, M C Rojas-Anaya, A de-la-Torre
Zika virus (ZIKV) infection is an emergent worldwide public health problem. Historically, 84 countries have reported vector-borne ZIKV transmission, 61 of which report on-going transmission. It is a Flavivirus transmitted through arthropods belonging to the Aedes genus. Since 2015, ZIKV infections have increased dramatically; with 1.3 million people infected during 2015 in Brazil alone. This paper's objective is to highlight the conjectural epidemiological points of the virus' dissemination. The digital archives Pubmed, MEDLINE, EMBASE and Cochrane were searched for papers that assessed aspects of ZIKV transmission and epidemiology...
March 14, 2018: Epidemiology and Infection
Han Xia, Yujuan Wang, Evans Atoni, Bo Zhang, Zhiming Yuan
Mosquitoes are classified into approximately 3500 species and further grouped into 41 genera. Epidemiologically, they are considered to be among the most important disease vectors in the world and they can harbor a wide variety of viruses. Several mosquito viruses are considered to be of significant medical importance and can cause serious public health issues throughout the world. Such viruses are Japanese encephalitis virus (JEV), dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV). Others are the newly recognized mosquito viruses such as Banna virus (BAV) and Yunnan orbivirus (YNOV) with unclear medical significance...
March 12, 2018: Virologica Sinica
Josef Zapletal, Madhav Erraguntla, Zach N Adelman, Kevin M Myles, Mark A Lawley
The increasing range of Aedes aegypti, vector for Zika, dengue, chikungunya, and other viruses, has brought attention to the need to understand the population and transmission dynamics of this mosquito. It is well understood that environmental factors and breeding site characteristics play a role in organismal development and the potential to transmit pathogens. In this study, we observe the impact of larval density in combination with diurnal temperature on the time to pupation, emergence, and mortality of Aedes aegypti...
2018: PloS One
Anna M Stewart-Ibarra, Sadie J Ryan, Aileen Kenneson, Christine A King, Mark Abbott, Arturo Barbachano-Guerrero, Efraín Beltrán-Ayala, Mercy J Borbor-Cordova, Washington B Cárdenas, Cinthya Cueva, Julia L Finkelstein, Christina D Lupone, Richard G Jarman, Irina Maljkovic Berry, Saurabh Mehta, Mark Polhemus, Mercy Silva, Timothy P Endy
Here, we report the findings from the first 2 years of an arbovirus surveillance study conducted in Machala, Ecuador, a dengue-endemic region (2014-2015). Patients with suspected dengue virus (DENV) infections (index cases, N = 324) were referred from five Ministry of Health clinical sites. A subset of DENV-positive index cases ( N = 44) were selected, and individuals from the index household and four neighboring homes within 200 m were recruited ( N = 400). Individuals who entered the study, other than the index cases, are referred to as associates...
March 5, 2018: American Journal of Tropical Medicine and Hygiene
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