Lisa A Ridnour, Robert Y S Cheng, William F Heinz, Milind Pore, Ana L Gonzalez, Elise L Femino, Rebecca Moffat, Adelaide L Wink, Fatima Imtiaz, Leandro Coutinho, Donna Butcher, Elijah F Edmondson, M Cristina Rangel, Stephen T C Wong, Stanley Lipkowitz, Sharon Glynn, Michael P Vitek, Daniel W McVicar, Xiaoxian Li, Stephen K Anderson, Nazareno Paolocci, Stephen M Hewitt, Stefan Ambs, Timothy R Billiar, Jenny C Chang, Stephen J Lockett, David A Wink
Multiple immunosuppressive mechanisms exist in the tumor microenvironment that drive poor outcomes and decrease treatment efficacy. The co-expression of NOS2 and COX2 is a strong predictor of poor prognosis in ER- breast cancer and other malignancies. Together, they generate pro-oncogenic signals that drive metastasis, drug resistance, cancer stemness, and immune suppression. Using an ER- breast cancer patient cohort, we found that the spatial expression patterns of NOS2 and COX2 with CD3+CD8+PD1- T effector (Teff) cells formed a tumor immune landscape that correlated with poor outcome...
December 23, 2023: bioRxiv