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Intraamniotic

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https://www.readbyqxmd.com/read/27836365/transamniotic-stem-cell-therapy-trascet-in-a-leporine-model-of-gastroschisis
#1
Christina Feng, Christopher D Graham, Hester F Shieh, Joseph A Brazzo, John Patrick Connors, Lucas Rohrer, Alexander Papadakis, David Zurakowski, Dario O Fauza
BACKGROUND/PURPOSE: Transamniotic stem cell therapy (TRASCET) with amniotic fluid mesenchymal stem cells (afMSCs) has been shown to mitigate bowel damage in a rodent model of gastroschisis. As a prerequisite to clinical translation, we sought to study TRASCET in a larger animal model. METHODS: New Zealand rabbit fetuses (n=64) with surgically created gastroschisis were divided into three groups. One group (untreated) had no further manipulations. Two groups received volume-matched intraamniotic injections of either saline or a suspension of afMSCs...
October 26, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27440743/aquaporins-in-ovine-amnion-responses-to-altered-amniotic-fluid-volumes-and-intramembranous-absorption-rates
#2
Cecilia Y Cheung, Debra F Anderson, Robert A Brace
Aquaporins (AQPs) are transmembrane channel proteins that facilitate rapid water movement across cell membranes. In amniotic membrane, the AQP-facilitated transfer of water across amnion cells has been proposed as a mechanism for amniotic fluid volume (AFV) regulation. To investigate whether AQPs modulate AFV by altering intramembranous absorption (IMA) rate, we tested the hypothesis that AQP gene expression in the amnion is positively correlated with IMA rate during experimental conditions when IMA rate and AFV are modified over a wide range...
July 2016: Physiological Reports
https://www.readbyqxmd.com/read/27265200/intraamniotic-inflammation-and-umbilical-cord-blood-interleukin-6-concentrations-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-membranes
#3
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Ondrej Soucek, Martin Stepan, Tomas Bestvina, Richard Spacek, Bo Jacobsson, Teresa Cobo, Marian Kacerovsky
OBJECTIVE: To evaluate umbilical cord blood interleukin (IL)-6 concentrations and the occurrence of fetal inflammatory response syndrome (FIRS) with respect to microbial invasion of the amniotic cavity (MIAC) and/or intraamniotic inflammation (IAI) in pregnancies complicated by preterm prelabor rupture of membranes (PPROM). METHODS: One-hundred-eighty-eight women with singleton pregnancies complicated by PPROM between gestational ages of 24 + 0 and 36 + 6 weeks were included in the study...
June 20, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27013425/a-comparison-between-placental-and-amniotic-mesenchymal-stem-cells-for-transamniotic-stem-cell-therapy-trascet-in-experimental-spina-bifida
#4
Christina Feng, Christopher D Graham, John Patrick Connors, Joseph Brazzo, David Zurakowski, Dario O Fauza
PURPOSE: We compared placental-derived and amniotic fluid-derived mesenchymal stem cells (pMSCs and afMSCs, respectively) in transamniotic stem cell therapy (TRASCET) for experimental spina bifida. METHODS: Pregnant dams (n=29) exposed to retinoic acid for the induction of fetal spina bifida were divided into four groups. Three groups received volume-matched intraamniotic injections of either saline (n=38 fetuses) or a suspension of 2×10(6) cells/mL of syngeneic, labeled afMSCs (n=73) or pMSCs (n=115) on gestational day 17 (term=21-22days)...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26953684/amniotic-fluid-calreticulin-in-pregnancies-complicated-by-the-preterm-prelabor-rupture-of-membranes
#5
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Ondrej Soucek, Radka Kutova, Lenka Pliskova, Richard Spacek, Piotr Laudanski, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: This study aimed to determine the amniotic fluid calreticulin concentrations in women with the preterm prelabor rupture of membranes (PPROM) based on the microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI) and microbial-associated IAI. METHODS: One hundred sixty-eight women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for calreticulin concentrations by ELISA...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26816951/successful-management-of-live-cervical-ectopic-pregnancy-a-case-report
#6
Sunita Samal, Seetesh Ghose, P Pallavee, P Porkkodi
Cervical pregnancy is a rare form of ectopic pregnancy with potential grave consequences occurring in approximately 1:9,000 deliveries. It is life-threatening as the pregnancy is implanted in the endocervical canal and the trophoblast can penetrate through the cervical wall and into the uterine blood supply resulting in catastrophic haemorrhage. Historically, the treatment had been hysterectomy because of the considerable risk of life-threatening haemorrhage, but in the recent past various conservative management modalities have been applied to preserve fertility...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26793746/mass-spectrometric-detection-of-biomarkers-for-early-assessment-of-intraamniotic-fluid-infection
#7
Consuelo Cháfer-Pericás, Vedran Stefanovic, Ángel Sánchez-Illana, Javier Escobar, María Cernada, Elena Cubells, Antonio Núñez-Ramiro, Sture Andersson, Máximo Vento, Julia Kuligowski
This data article contains information on glutathione sulfonamide (GSA) structural confirmation and purity after synthesis, as well as mass spectrometry acquisition parameters for the determination of GSA and other biomarkers for the early assessment of intraamniotic fluid infection in amniotic fluid samples (Cháfer-Pericás et al., 2015) [1]. GSA standards were synthesized and structural confirmation was carried out employing time-of-flight mass spectrometry (TOF-MS); purity was assessed by high performance liquid chromatography (HPLC) with UV detection...
December 2015: Data in Brief
https://www.readbyqxmd.com/read/26741155/-cytological-energetic-principle-of-the-amniotic-fluid-examination-on-female-patients-with-diagnosis-of-preterm-premature-rupture-of-membranes-up-to-now-experiences-and-perspectives
#8
K Müllerová, P Kelbich, M Švecová
In our study we have dealt with the amniotic fluid examination on female patients with diagnosis of preterm premature rupture of membranes (PPROM). For one of the most important task in the feto-maternal medicine we consider the discovered method of amniotic fluid examination which is capable of the earliest possible detection in an intraamniotic inflammatory response. Unnoticed could harm or in the most serious cases threat the life of fetus or its mother. This was also the main reason why we chose this topic for our study...
December 2015: Ceská Gynekologie
https://www.readbyqxmd.com/read/26548631/transamniotic-stem-cell-therapy-trascet-mitigates-bowel-damage-in-a-model-of-gastroschisis
#9
Christina Feng, Christopher D Graham, John Patrick Connors, Joseph Brazzo, Amy H S Pan, James R Hamilton, David Zurakowski, Dario O Fauza
PURPOSE: We sought to determine whether intraamniotic delivery of concentrated amniotic-derived mesenchymal stem cells (afMSCs) could reduce damage to exposed bowel in experimental gastroschisis. METHODS: Rat fetuses (n=117) with surgically created gastroschisis were divided into three groups: untreated animals (n=62) and two groups receiving volume-matched intraamniotic injections of either saline (n=25) or 2 × 10(6) cells/mL of syngeneic, labeled afMSCs (n=30)...
January 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26512976/amniotic-fluid-prostaglandin-e2-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-the-membranes
#10
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Helena Hornychova, Bo Jacobsson, Ramkumar Menon, Piotr Laudanski, Martin Stepan, Tomas Bestvina, Marian Kacerovsky
OBJECTIVE: To determine amniotic fluid prostaglandin E2 concentrations in women preterm prelabor rupture of the membranes (PPROM) with respect to microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI), microbial-associated IAI, histological chorioamnionitis, and short-term neonatal morbidity. METHODS: One hundred forty-five women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for prostaglandin E2 concentrations by ELISA...
September 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26456057/novel-biomarkers-in-amniotic-fluid-for-early-assessment-of-intraamniotic-infection
#11
Consuelo Cháfer-Pericás, Vedran Stefanovic, Ángel Sánchez-Illana, Javier Escobar, María Cernada, Elena Cubells, Antonio Núñez-Ramiro, Sture Andersson, Máximo Vento, Julia Kuligowski
Intra-amniotic infection/inflammation (IAI) is associated with preterm birth, short and long-term adverse clinical outcomes and oxidative stress. The diagnosis of IAI is based on histological and clinical findings; however, often these results are unspecific. Therefore, efforts have been directed towards validating reliable methods for patients lacking overt clinical symptoms. In this study, amniotic fluid (AF) samples were prospectively collected from 23 women grouped into two categories (with or without IAI) following clinical, microbiological and histological criteria...
December 2015: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26428501/acute-chorioamnionitis-and-funisitis-definition-pathologic-features-and-clinical-significance
#12
REVIEW
Chong Jai Kim, Roberto Romero, Piya Chaemsaithong, Noppadol Chaiyasit, Bo Hyun Yoon, Yeon Mee Kim
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and chorionic vasculitis and represent a host response (maternal or fetal) to a chemotactic gradient in the amniotic cavity. While acute chorioamnionitis is evidence of a maternal host response, funisitis and chorionic vasculitis represent fetal inflammatory responses. Intraamniotic infection generally has been considered to be the cause of acute chorioamnionitis and funisitis; however, recent evidence indicates that "sterile" intraamniotic inflammation, which occurs in the absence of demonstrable microorganisms induced by "danger signals," is frequently associated with these lesions...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26408085/outside-in-acute-fetal-systemic-inflammation-in-very-preterm-chronically-catheterized-sheep-fetuses-is-not-driven-by-cells-in-the-fetal-blood
#13
Matthew W Kemp, Timothy J Molloy, Haruo Usuda, Eleanor Woodward, Yuichiro Miura, Matthew S Payne, Demelza J Ireland, Alan H Jobe, Suhas G Kallapur, Sarah J Stock, Owen B Spiller, John P Newnham, Masatoshi Saito
BACKGROUND: The preterm birth syndrome (delivery before 37 weeks gestation) is a major contributor to the global burden of perinatal morbidity and death. The cause of preterm birth is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine infection is frequent in preterm deliveries that occur at <32 weeks gestation; understanding how the fetus responds to proinflammatory insult will be an important step towards early preterm birth prevention...
February 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26294950/leptotrichia-buccalis-a-novel-cause-of-chorioamnionitis
#14
Marcela C Smid, Sarah K Dotters-Katz, Rongpong Plongla, Kim A Boggess
Intra-amniotic Leptotrichia buccalis has not been previously associated with adverse pregnancy outcome. We report a case of chorioamnionitis and pregnancy loss associated with this primarily oral commensal. We review Leptotrichia buccalis and other oral commensals that have been identified in cases of intraamniotic infection.
April 15, 2015: Infectious Disease Reports
https://www.readbyqxmd.com/read/26284599/uterine-overdistention-induces-preterm-labor-mediated-by-inflammation-observations-in-pregnant-women-and-nonhuman-primates
#15
Kristina M Adams Waldorf, Natasha Singh, Aarthi R Mohan, Roger C Young, Lisa Ngo, Ananya Das, Jesse Tsai, Aasthaa Bansal, Louis Paolella, Bronwen R Herbert, Suren R Sooranna, G Michael Gough, Cliff Astley, Keith Vogel, Audrey E Baldessari, Theodor K Bammler, James MacDonald, Michael G Gravett, Lakshmi Rajagopal, Mark R Johnson
OBJECTIVE: Uterine overdistention is thought to induce preterm labor in women with twin and multiple pregnancies, but the pathophysiology remains unclear. We investigated for the first time the pathogenesis of preterm birth associated with rapid uterine distention in a pregnant nonhuman primate model. STUDY DESIGN: A nonhuman primate model of uterine overdistention was created using preterm chronically catheterized pregnant pigtail macaques (Macaca nemestrina) by inflation of intraamniotic balloons (N = 6), which were compared to saline controls (N = 5)...
December 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26232508/evidence-of-perturbations-of-the-cytokine-network-in-preterm-labor
#16
Roberto Romero, Jean-Charles Grivel, Adi L Tarca, Piya Chaemsaithong, Zhonghui Xu, Wendy Fitzgerald, Sonia S Hassan, Tinnakorn Chaiworapongsa, Leonid Margolis
OBJECTIVE: Intraamniotic inflammation/infection is the only mechanism of disease with persuasive evidence of causality for spontaneous preterm labor/delivery. Previous studies about the behavior of cytokines in preterm labor have been largely based on the analysis of the behavior of each protein independently. Emerging evidence indicates that the study of biologic networks can provide insight into the pathobiology of disease and improve biomarker discovery. The goal of this study was to characterize the inflammatory-related protein network in the amniotic fluid of patients with preterm labor...
December 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26208287/intraamniotic-inflammation-in-women-with-preterm-prelabor-rupture-of-membranes
#17
Ivana Musilova, Radka Kutová, Lenka Pliskova, Martin Stepan, Ramkumar Menon, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: To characterize subgroups of preterm prelabor rupture of membranes (PPROM) and short-term neonatal outcomes based on the presence and absence of intraamniotic inflammation (IAI) and/or microbial invasion of the amniotic cavity (MIAC). METHODS: One hundred and sixty-six Caucasian women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis (n=166) and were assayed for interleukin-6 levels by a lateral flow immunoassay...
2015: PloS One
https://www.readbyqxmd.com/read/25993616/cervical-microbiota-in-women-with-preterm-prelabor-rupture-of-membranes
#18
Marian Kacerovsky, Filip Vrbacky, Radka Kutova, Lenka Pliskova, Ctirad Andrys, Ivana Musilova, Ramkumar Menon, Ronald Lamont, Jana Nekvindova
OBJECTIVE: To analyze the cervical microbiota in women with preterm prelabor rupture of membranes (PPROM) by pyrosequencing and to document associations between cervical microbiota, cervical inflammatory response, microbial invasion of the amniotic cavity (MIAC), histological chorioamnionitis, and intraamniotic infection (IAI). STUDY DESIGN: Sixty-one women with singleton pregnancies complicated by PPROM were included in the study. Specimens of cervical and amniotic fluid were collected on admission...
2015: PloS One
https://www.readbyqxmd.com/read/25953932/prevention-and-treatment-strategy-in-pregnant-women-with-group-b-streptococcal-infection
#19
G Tevdorashvili, D Tevdorashvili, M Andghuladze, M Tevdorashvili
Group B streptococcus (GBS; Streptococcus agalactiae) are encapsulated gram-positive cocci belonging to Lancefield group B, that frequently colonizes the human genital and gastrointestinal tracts. It is an important cause of illness in three categories of population: infants, pregnant women, and adults with underlying medical conditions. In pregnant women and postpartum women, GBS is a frequent cause of asymptomatic bacteriuria, urinary tract infection, upper genital tract infection (i.e. intraamniotic infection or chorioamnionitis), postpartum endometritis (8%), pneumonia (2%), puerperal sepsis (2%), and bacteremia without a focal site (31%)...
April 2015: Georgian Medical News
https://www.readbyqxmd.com/read/25793992/oral-nasal-and-pharyngeal-exposure-to-lipopolysaccharide-causes-a-fetal-inflammatory-response-in-sheep
#20
Gunlawadee Maneenil, Matthew W Kemp, Paranthaman Senthamarai Kannan, Boris W Kramer, Masatoshi Saito, John P Newnham, Alan H Jobe, Suhas G Kallapur
BACKGROUND: A fetal inflammatory response (FIR) in sheep can be induced by intraamniotic or selective exposure of the fetal lung or gut to lipopolysaccharide (LPS). The oral, nasal, and pharyngeal cavities (ONP) contain lymphoid tissue and epithelium that are in contact with the amniotic fluid. The ability of the ONP epithelium and lymphoid tissue to initiate a FIR is unknown. OBJECTIVE: To determine if FIR occurs after selective ONP exposure to LPS in fetal sheep...
2015: PloS One
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