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Intraamniotic

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https://www.readbyqxmd.com/read/28742677/committee-opinion-no-712-intrapartum-management-of-intraamniotic-infection
#1
(no author information available yet)
Intraamniotic infection, also known as chorioamnionitis, is an infection with resultant inflammation of any combination of the amniotic fluid, placenta, fetus, fetal membranes, or decidua. Intraamniotic infection is a common condition noted among preterm and term parturients. However, most cases of intraamniotic infection detected and managed by obstetrician-gynecologists or other obstetric care providers will be noted among term patients in labor. Intraamniotic infection can be associated with acute neonatal morbidity, including neonatal pneumonia, meningitis, sepsis, and death...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742671/committee-opinion-no-712-summary-intrapartum-management-of-intraamniotic-infection
#2
(no author information available yet)
Intraamniotic infection, also known as chorioamnionitis, is an infection with resultant inflammation of any combination of the amniotic fluid, placenta, fetus, fetal membranes, or decidua. Intraamniotic infection is a common condition noted among preterm and term parturients. However, most cases of intraamniotic infection detected and managed by obstetrician-gynecologists or other obstetric care providers will be noted among term patients in labor. Intraamniotic infection can be associated with acute neonatal morbidity, including neonatal pneumonia, meningitis, sepsis, and death...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28708576/adiponectin-concentration-in-mid-trimester-amniotic-fluid-varies-with-the-%C3%AE-amylase-level-and-maternal-and-neonatal-outcomes
#3
Joseph Chervenak, Mio Sawai, Lamis El Kabab, Rahul Lohana, Daniel Skupski, Steven S Witkin
OBJECTIVE: Factors influencing intraamniotic adiponectin levels and their functional significance remain incompletely elucidated. We prospectively measured adiponectin in amniotic fluid and identified its associations with maternal parameters, mediators in amniotic fluid and pregnancy outcomes. STUDY DESIGN: Mid-trimester amniotic fluid from 571 women was tested for adiponectin, interleukin (IL)-6, IL-8 and α-amylase by enzyme-linked immunosorbant assay (ELISA), after which clinical data were obtained...
July 14, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28620499/intrauterine-death-following-intraamniotic-triiodothyronine-and-thyroxine-therapy-for-fetal-goitrous-hypothyroidism-associated-with-polyhydramnios-and-caused-by-a-thyroglobulin-mutation
#4
Pradeep Vasudevan, Corrina Powell, Adeline K Nicholas, Ian Scudamore, James Greening, Soo-Mi Park, Nadia Schoenmakers
In the absence of maternal thyroid disease or iodine deficiency, fetal goitre is rare and usually attributable to dyshormonogenesis, for which genetic ascertainment is not always undertaken in the UK. Mechanical complications include tracheal and oesophageal compression with resultant polyhydramnios, malpresentation at delivery and neonatal respiratory distress. We report an Indian kindred in which the proband (first-born son) had congenital hypothyroidism (CH) without obvious neonatal goitre. His mother's second pregnancy was complicated by fetal hypothyroid goitre and polyhydramnios, prompting amniotic fluid drainage and intraamniotic therapy (with liothyronine, T3 and levothyroxine, T4)...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28502201/prediction-of-chorioamnionitis-in-cases-of-intraamniotic-infection-by-ureaplasma-urealyticum-in-women-with-very-preterm-premature-rupture-of-membranes-or-preterm-labour
#5
Rocio Revello, María José Alcaide, Daniel Abehsera, María Martin-Camean, Mafalda Sousa E Faro Gomes, Bárbara Alonso-Luque, Jose L Bartha
OBJECTIVES: First, to determinate the frequency of chorioamnionitis and funisitis in cases of intramniotic detection of Ureaplasma urealyticum. Second, to assess the predictive capability of some biological markers in the amniotic fluid of these women to predict histological inflammation. SUBJECTS AND METHODS: We prospectively studied 20 cases of women with premature rupture of membranes or preterm labour (PROM) or preterm labour and intraamniotic detection of Ureaplasma urealyticum...
June 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28363468/donor-mesenchymal-stem-cells-home-to-maternal-wounds-after-transamniotic-stem-cell-therapy-trascet-in-a-rodent-model
#6
Christopher D Graham, Hester F Shieh, Joseph A Brazzo, David Zurakowski, Dario O Fauza
PURPOSE: Transamniotic stem cell therapy (TRASCET) with amniotic fluid-derived MSCs (afMSCs) has emerged experimentally as a practical treatment strategy for congenital anomalies. In this study, we sought to determine whether afMSCs migrate to the mother following TRASCET. METHODS: Pregnant rat dams were divided into three groups. Two groups received volume-matched injections into all amniotic cavities of either a suspension of afMSCs labeled with a luciferase reporter gene or the luciferase protein alone...
June 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28029371/the-role-of-water-soluble-meconium-subfraction-and-lipid-soluble-meconium-subfraction-on-the-superior-mesenteric-artery-vasoconstriction-in-chick-embryos
#7
Serdar Şiyve, Oktay Ulusoy, Osman Z Karakuş, Nergis Murat, Mehmet E Uslu, Oğuz Ateş, Gülce Hakgüder, Mustafa Olguner, Feza M Akgür
OBJECTIVE: Intraamniotic meconium has been responsible for intestinal damage in gastroschisis and meconium-dependent intestinal ischemia has been proposed to induce additional intestinal damage in gastroschisis. This study is aimed to determine the effects of lipid and water-soluble meconium subfractions on the contractility of the superior mesenteric artery (SMA). MATERIALS AND METHODS: The study was conducted on 18-day fertilized chick embryos (Gallus Domesticus)...
March 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27836365/transamniotic-stem-cell-therapy-trascet-in-a-leporine-model-of-gastroschisis
#8
Christina Feng, Christopher D Graham, Hester F Shieh, Joseph A Brazzo, John Patrick Connors, Lucas Rohrer, Alexander Papadakis, David Zurakowski, Dario O Fauza
BACKGROUND/PURPOSE: Transamniotic stem cell therapy (TRASCET) with amniotic fluid mesenchymal stem cells (afMSCs) has been shown to mitigate bowel damage in a rodent model of gastroschisis. As a prerequisite to clinical translation, we sought to study TRASCET in a larger animal model. METHODS: New Zealand rabbit fetuses (n=64) with surgically created gastroschisis were divided into three groups. One group (untreated) had no further manipulations. Two groups received volume-matched intraamniotic injections of either saline or a suspension of afMSCs...
January 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27440743/aquaporins-in-ovine-amnion-responses-to-altered-amniotic-fluid-volumes-and-intramembranous-absorption-rates
#9
Cecilia Y Cheung, Debra F Anderson, Robert A Brace
Aquaporins (AQPs) are transmembrane channel proteins that facilitate rapid water movement across cell membranes. In amniotic membrane, the AQP-facilitated transfer of water across amnion cells has been proposed as a mechanism for amniotic fluid volume (AFV) regulation. To investigate whether AQPs modulate AFV by altering intramembranous absorption (IMA) rate, we tested the hypothesis that AQP gene expression in the amnion is positively correlated with IMA rate during experimental conditions when IMA rate and AFV are modified over a wide range...
July 2016: Physiological Reports
https://www.readbyqxmd.com/read/27265200/intraamniotic-inflammation-and-umbilical-cord-blood-interleukin-6-concentrations-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-membranes
#10
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Ondrej Soucek, Martin Stepan, Tomas Bestvina, Richard Spacek, Bo Jacobsson, Teresa Cobo, Marian Kacerovsky
OBJECTIVE: To evaluate umbilical cord blood interleukin (IL)-6 concentrations and the occurrence of fetal inflammatory response syndrome (FIRS) with respect to microbial invasion of the amniotic cavity (MIAC) and/or intraamniotic inflammation (IAI) in pregnancies complicated by preterm prelabor rupture of membranes (PPROM). METHODS: One-hundred-eighty-eight women with singleton pregnancies complicated by PPROM between gestational ages of 24 + 0 and 36 + 6 weeks were included in the study...
June 20, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27013425/a-comparison-between-placental-and-amniotic-mesenchymal-stem-cells-for-transamniotic-stem-cell-therapy-trascet-in-experimental-spina-bifida
#11
COMPARATIVE STUDY
Christina Feng, Christopher D Graham, John Patrick Connors, Joseph Brazzo, David Zurakowski, Dario O Fauza
PURPOSE: We compared placental-derived and amniotic fluid-derived mesenchymal stem cells (pMSCs and afMSCs, respectively) in transamniotic stem cell therapy (TRASCET) for experimental spina bifida. METHODS: Pregnant dams (n=29) exposed to retinoic acid for the induction of fetal spina bifida were divided into four groups. Three groups received volume-matched intraamniotic injections of either saline (n=38 fetuses) or a suspension of 2×10(6) cells/mL of syngeneic, labeled afMSCs (n=73) or pMSCs (n=115) on gestational day 17 (term=21-22days)...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26953684/amniotic-fluid-calreticulin-in-pregnancies-complicated-by-the-preterm-prelabor-rupture-of-membranes
#12
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Ondrej Soucek, Radka Kutova, Lenka Pliskova, Richard Spacek, Piotr Laudanski, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: This study aimed to determine the amniotic fluid calreticulin concentrations in women with the preterm prelabor rupture of membranes (PPROM) based on the microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI) and microbial-associated IAI. METHODS: One hundred sixty-eight women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for calreticulin concentrations by ELISA...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26816951/successful-management-of-live-cervical-ectopic-pregnancy-a-case-report
#13
Sunita Samal, Seetesh Ghose, P Pallavee, P Porkkodi
Cervical pregnancy is a rare form of ectopic pregnancy with potential grave consequences occurring in approximately 1:9,000 deliveries. It is life-threatening as the pregnancy is implanted in the endocervical canal and the trophoblast can penetrate through the cervical wall and into the uterine blood supply resulting in catastrophic haemorrhage. Historically, the treatment had been hysterectomy because of the considerable risk of life-threatening haemorrhage, but in the recent past various conservative management modalities have been applied to preserve fertility...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26793746/mass-spectrometric-detection-of-biomarkers-for-early-assessment-of-intraamniotic-fluid-infection
#14
Consuelo Cháfer-Pericás, Vedran Stefanovic, Ángel Sánchez-Illana, Javier Escobar, María Cernada, Elena Cubells, Antonio Núñez-Ramiro, Sture Andersson, Máximo Vento, Julia Kuligowski
This data article contains information on glutathione sulfonamide (GSA) structural confirmation and purity after synthesis, as well as mass spectrometry acquisition parameters for the determination of GSA and other biomarkers for the early assessment of intraamniotic fluid infection in amniotic fluid samples (Cháfer-Pericás et al., 2015) [1]. GSA standards were synthesized and structural confirmation was carried out employing time-of-flight mass spectrometry (TOF-MS); purity was assessed by high performance liquid chromatography (HPLC) with UV detection...
December 2015: Data in Brief
https://www.readbyqxmd.com/read/26741155/-cytological-energetic-principle-of-the-amniotic-fluid-examination-on-female-patients-with-diagnosis-of-preterm-premature-rupture-of-membranes-up-to-now-experiences-and-perspectives
#15
K Müllerová, P Kelbich, M Švecová
In our study we have dealt with the amniotic fluid examination on female patients with diagnosis of preterm premature rupture of membranes (PPROM). For one of the most important task in the feto-maternal medicine we consider the discovered method of amniotic fluid examination which is capable of the earliest possible detection in an intraamniotic inflammatory response. Unnoticed could harm or in the most serious cases threat the life of fetus or its mother. This was also the main reason why we chose this topic for our study...
December 2015: Ceská Gynekologie
https://www.readbyqxmd.com/read/26548631/transamniotic-stem-cell-therapy-trascet-mitigates-bowel-damage-in-a-model-of-gastroschisis
#16
Christina Feng, Christopher D Graham, John Patrick Connors, Joseph Brazzo, Amy H S Pan, James R Hamilton, David Zurakowski, Dario O Fauza
PURPOSE: We sought to determine whether intraamniotic delivery of concentrated amniotic-derived mesenchymal stem cells (afMSCs) could reduce damage to exposed bowel in experimental gastroschisis. METHODS: Rat fetuses (n=117) with surgically created gastroschisis were divided into three groups: untreated animals (n=62) and two groups receiving volume-matched intraamniotic injections of either saline (n=25) or 2 × 10(6) cells/mL of syngeneic, labeled afMSCs (n=30)...
January 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26512976/amniotic-fluid-prostaglandin-e2-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-the-membranes
#17
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Helena Hornychova, Bo Jacobsson, Ramkumar Menon, Piotr Laudanski, Martin Stepan, Tomas Bestvina, Marian Kacerovsky
OBJECTIVE: To determine amniotic fluid prostaglandin E2 concentrations in women preterm prelabor rupture of the membranes (PPROM) with respect to microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI), microbial-associated IAI, histological chorioamnionitis, and short-term neonatal morbidity. METHODS: One hundred forty-five women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for prostaglandin E2 concentrations by ELISA...
September 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26456057/novel-biomarkers-in-amniotic-fluid-for-early-assessment-of-intraamniotic-infection
#18
Consuelo Cháfer-Pericás, Vedran Stefanovic, Ángel Sánchez-Illana, Javier Escobar, María Cernada, Elena Cubells, Antonio Núñez-Ramiro, Sture Andersson, Máximo Vento, Julia Kuligowski
Intra-amniotic infection/inflammation (IAI) is associated with preterm birth, short and long-term adverse clinical outcomes and oxidative stress. The diagnosis of IAI is based on histological and clinical findings; however, often these results are unspecific. Therefore, efforts have been directed towards validating reliable methods for patients lacking overt clinical symptoms. In this study, amniotic fluid (AF) samples were prospectively collected from 23 women grouped into two categories (with or without IAI) following clinical, microbiological and histological criteria...
December 2015: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26428501/acute-chorioamnionitis-and-funisitis-definition-pathologic-features-and-clinical-significance
#19
REVIEW
Chong Jai Kim, Roberto Romero, Piya Chaemsaithong, Noppadol Chaiyasit, Bo Hyun Yoon, Yeon Mee Kim
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and chorionic vasculitis and represent a host response (maternal or fetal) to a chemotactic gradient in the amniotic cavity. While acute chorioamnionitis is evidence of a maternal host response, funisitis and chorionic vasculitis represent fetal inflammatory responses. Intraamniotic infection generally has been considered to be the cause of acute chorioamnionitis and funisitis; however, recent evidence indicates that "sterile" intraamniotic inflammation, which occurs in the absence of demonstrable microorganisms induced by "danger signals," is frequently associated with these lesions...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26408085/outside-in-acute-fetal-systemic-inflammation-in-very-preterm-chronically-catheterized-sheep-fetuses-is-not-driven-by-cells-in-the-fetal-blood
#20
Matthew W Kemp, Timothy J Molloy, Haruo Usuda, Eleanor Woodward, Yuichiro Miura, Matthew S Payne, Demelza J Ireland, Alan H Jobe, Suhas G Kallapur, Sarah J Stock, Owen B Spiller, John P Newnham, Masatoshi Saito
BACKGROUND: The preterm birth syndrome (delivery before 37 weeks gestation) is a major contributor to the global burden of perinatal morbidity and death. The cause of preterm birth is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine infection is frequent in preterm deliveries that occur at <32 weeks gestation; understanding how the fetus responds to proinflammatory insult will be an important step towards early preterm birth prevention...
February 2016: American Journal of Obstetrics and Gynecology
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