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Ischemic preconditioning

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https://www.readbyqxmd.com/read/29032754/pharmacological-neuroprotection-in-cardiac-surgery-effectiveness-of-pharmacologic-preconditioning-with-erythromycin
#1
Charilaos-Panagiotis C Koutsogiannidis, Elizabeth O Johnson
Regardless of the degree of advances in neuroprotective strategies, and despite the technological progress in neuromonitoring, brain injury still remains the "Achilles' heel" in cardiac surgery. A large number of pharmacological and non-pharmacological therapeutic interventions have been investigated during the last two decades. Recently, both theoretical and experimental findings suggest benefits of pharmacological cerebral protection, although, there is no conclusive evidence of clinical superiority of specific agents that have been applied as neuroprotectants, in human randomized controlled trials...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29027964/microglia-and-monocytes-macrophages-polarization-reveal-novel-therapeutic-mechanism-against-stroke
#2
REVIEW
Masato Kanazawa, Itaru Ninomiya, Masahiro Hatakeyama, Tetsuya Takahashi, Takayoshi Shimohata
Stroke is a leading cause of morbidity and mortality worldwide, and consists of two types, ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival rate or improve the quality of life after ischemic and hemorrhagic stroke in the subacute to chronic phases. Therefore, it is necessary to establish therapeutic strategies to facilitate functional recovery in patients with stroke during both phases. Cell-based therapies, using microglia and monocytes/macrophages preconditioned by optimal stimuli and/or any therapies targeting these cells, might be an ideal therapeutic strategy for managing stroke...
October 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29022562/ketogenic-diet-in-endocrine-disorders-current-perspectives
#3
REVIEW
L Gupta, D Khandelwal, S Kalra, P Gupta, D Dutta, S Aggarwal
Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome...
October 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29018188/cardioprotection-induced-in-a-mouse-model-of-neuropathic-pain-via-anterior-nucleus-of-paraventricular-thalamus
#4
Yi-Fen Cheng, Ya-Ting Chang, Wei-Hsin Chen, Hsi-Chien Shih, Yen-Hui Chen, Bai-Chuang Shyu, Chien-Chang Chen
Myocardial infarction is the leading cause of death worldwide. Restoration of blood flow rescues myocardium but also causes ischemia-reperfusion injury. Here, we show that in a mouse model of chronic neuropathic pain, ischemia-reperfusion injury following myocardial infarction is reduced, and this cardioprotection is induced via an anterior nucleus of paraventricular thalamus (PVA)-dependent parasympathetic pathway. Pharmacological inhibition of extracellular signal-regulated kinase activation in the PVA abolishes neuropathic pain-induced cardioprotection, whereas activation of PVA neurons pharmacologically, or optogenetic stimulation, is sufficient to induce cardioprotection...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29017857/administration-of-5-methoxyindole-2-carboxylic-acid-that-potentially-targets-mitochondrial-dihydrolipoamide-dehydrogenase-confers-cerebral-preconditioning-against-ischemic-stroke-injury
#5
Jinzi Wu, Rongrong Li, Wenjun Li, Ming Ren, Nopporn Thangthaeng, Nathalie Sumien, Ran Liu, Shaohua Yang, James W Simpkins, Michael J Forster, Liang-Jun Yan
The objective of this study was to investigate a possible role of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as a chemical preconditioning target for neuroprotection against ischemic injury. We used 5-methoxyindole-2-carboxylic acid (MICA), a reportedly reversible DLDH inhibitor, as the preconditioning agent and administered MICA to rats mainly via dietary intake. Upon completion of 4 week's MICA treatment, rats underwent 1h transient ischemia and 24h reperfusion followed by tissue collection. Our results show that MICA protected the brain against ischemic stroke injury as the infarction volume of the brain from the MICA-treated group was significantly smaller than that from the control group...
October 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28988529/effect-of-anesthetics-on-efficiency-of-remote-ischemic-preconditioning
#6
D N Silachev, E A Usatikova, I B Pevzner, L D Zorova, V A Babenko, M V Gulyaev, Yu A Pirogov, E Yu Plotnikov, D B Zorov
Remote ischemic preconditioning of hind limbs (RIPC) is an effective method for preventing brain injury resulting from ischemia. However, in numerous studies RIPC has been used on the background of administered anesthetics, which also could exhibit neuroprotective properties. Therefore, investigation of the signaling pathways triggered by RIPC and the effect of anesthetics is important. In this study, we explored the effect of anesthetics (chloral hydrate and Zoletil) on the ability of RIPC to protect the brain from injury caused by ischemia and reperfusion...
September 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28987955/the-effects-of-dexmedetomidine-preconditioning-on-aged-rat-heart-of-ischaemia-reperfusion-injury
#7
Jing Dong, Xin Guo, Shuhua Yang, Lin Li
To assess the effect of dexmedetomidine on myocardial ischemia reperfusion injury in vivo aged rat heart. 40 healthy male, 20month aged, 350-400g Sprague-Dawley rats. Rats were divided into four groups randomly(n=10): group of ischemic preconditioning(IP group), group of Sham(CS group), group of dexmedetomidine(DP group), Ischemia-reperfusion injury group(IR group). The date of HR and ±dp/dtmax were detected before and after the occur of ischemia reperfusion. Superoxide dismutase (SOD) and malondialdehyde (MDA) activity were recorded; myocardial infarct size was calculated at the end of reperfusion...
September 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28986541/cyclophilin-d-ablation-is-associated-with-increased-end-ischemic-mitochondrial-hexokinase-activity
#8
Rianne Nederlof, Mark A M van den Elshout, Anneke Koeman, Laween Uthman, Iris Koning, Otto Eerbeek, Nina C Weber, Markus W Hollmann, Coert J Zuurbier
Both the absence of cyclophilin D (CypD) and the presence of mitochondrial bound hexokinase II (mtHKII) protect the heart against ischemia/reperfusion (I/R) injury. It is unknown whether CypD determines the amount of mtHKII in the heart. We examined whether CypD affects mtHK in normoxic, ischemic and preconditioned isolated mouse hearts. Wild type (WT) and CypD(-/-) mouse hearts were perfused with glucose only and subjected to 25 min ischemia and reperfusion. At baseline, cytosolic and mtHK was similar between hearts...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28980297/remote-ischemic-preconditioning-of-human-myocardium-ripe-study-protocol-for-a-double-blinded-randomized-controlled-trial
#9
Marek A Deja, Ryszard Wiaderkiewicz, Piotr Czekaj, Ewa Czech, Marcin Malinowski, Leszek Machej, Andrzej Węglarzy, Adam Kowalówka, Magda Piekarska, Bartosz Szurlej, Tomasz Latusek
BACKGROUND: Remote preconditioning was showed to be a potent protective phenomenon in many animals. Several studies aimed to demonstrate it was feasible in humans by trying to show its protective effect during cardiac surgery. Of these studies some small studies and one bigger trial were positive while two other bigger studies showed no effectiveness of remote preconditioning as assessed by levels of postoperatively released cardiac markers. Recently two large clinical trials also failed to prove the benefit of remote preconditioning in cardiac surgery...
October 5, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28978919/potential-humoral-mediators-of-remote-ischemic-preconditioning-in-patients-undergoing-surgical-coronary-revascularization
#10
Nilgün Gedik, Eva Kottenberg, Matthias Thielmann, Ulrich H Frey, Heinz Jakob, Jürgen Peters, Gerd Heusch, Petra Kleinbongard
Remote ischemic preconditioning (RIPC) by repeated brief cycles of limb ischemia/reperfusion may reduce myocardial ischemia/reperfusion injury and improve patients' prognosis after elective coronary artery bypass graft (CABG) surgery. The signal transducer and activator of transcription (STAT)5 activation in left ventricular myocardium is associated with RIPC´s cardioprotection. Cytokines and growth hormones typically activate STATs and could therefore act as humoral transfer factors of RIPC´s cardioprotection...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28973678/l-carnitine-attenuates-cardiac-dysfunction-by-ischemic-insults-through-akt-signaling-pathway
#11
Mei Xue, Xu Chen, Zhija Guo, Xiaoqian Liu, Yanping Bi, Jie Yin, Haiyan Hu, Ping Zhu, Jian Zhuang, Courtney Cates, Thomas Rousselle, Ji Li
We aim to investigate the cardioprotective effects of L-carnitine on cardiac function during ischemia and reperfusion (I/R) and contractile function of single cardiomyocyte. C57BL/6J mice were randomly assigned to 5 groups: sham group; vehicle group, L-carnitine preconditioning group (LC), LC preconditioning + LY294002 (a PI3K/Akt signaling pathway inhibitor) group (LC + LY), and LY294002 group (LY). The sham group was exposed to the open heart operation but not ischemia/reperfusion, the other groups received 45 min ischemia/48 hrs reperfusion...
September 9, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28972960/strategies-to-enhance-paracrine-potency-of-transplanted-mesenchymal-stem-cells-in-intractable-neonatal-disorders
#12
REVIEW
Won Soon Park, So Yoon Ahn, Se In Sung, Jee-Yin Ahn, Yun Sil Chang
Mesenchymal stem cell (MSC) transplantation represents the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia, hypoxic ischemic encephalopathy, and intraventricular hemorrhage. Absent engraftment and direct differentiation of transplanted MSCs, and the 'hit and run' therapeutic effects of these MSCs suggest that their pleiotropic protection might be attributable to paracrine activity via the secretion of various biologic factors rather than to regenerative activity...
October 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28966219/ischemic-preconditioning-in-skeletal-muscle
#13
Kazuho Sakamoto
No abstract text is available yet for this article.
2017: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/28964663/saffron-crocus-sativus-intake-provides-nutritional-preconditioning-against-myocardial-ischemia-reperfusion-injury-in-wild-type-and-apoe-mice-involvement-of-nrf2-activation
#14
P Efentakis, A Rizakou, E Christodoulou, A Chatzianastasiou, M G López, R León, E Balafas, N P E Kadoglou, I Tseti, H Skaltsa, N Kostomitsopoulos, E K Iliodromitis, G Valsami, I Andreadou
BACKGROUND AND AIMS: Saffron is an antioxidant herbal derivative; however, its efficacy as a nutritional cardioprotective agent has not been fully elucidated. We investigated the cardioprotective properties of a standardized saffron aqueous extract (SFE) against ischemia/reperfusion (I/R) injury in Wild-Type (WT) and ApoE((-/-)) mice and the underlying molecular mechanisms. METHODS AND RESULTS: WT and ApoE((-/-)) mice were subjected to 30 min I and 2 h R, with the following per os interventions for 4 weeks: 1) WT Control Group, receiving Water for Injection (WFI); 2) WT Crocus Group, receiving SFE at a dose of 60 mg/kg/day; 3) WT Crocus + Wort group, receiving SFE as described above and wortmannin at a dose of 60 μg/kg bolus 15 min before R; 4) ApoE((-/-)) Control Group, receiving WFI; 5) ApoE((-/-)) Crocus Group, receiving SFE at a dose of 60 mg/kg/day and 6) ApoE((-/-)) Crocus + Wort: receiving SFE as described above and wortmannin at a dose of 60 μg/kg bolus, 15 min before R...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28954945/ischemic-tolerance-of-the-brain-and-spinal-cord-a-review
#15
Masatoshi Yunoki, Takahiro Kanda, Kenta Suzuki, Atsuhito Uneda, Koji Hirashita, Kimihiro Yoshino
Ischemic tolerance is an endogenous neuroprotective phenomenon induced by sublethal ischemia. Ischemic preconditioning (IPC), the first discovered form of ischemic tolerance, is widely seen in many species and in various organs including the brain and the spinal cord. Ischemic tolerance of the spinal cord is less familiar among neurosurgeons, although it has been reported from the viewpoint of preventing ischemic spinal cord injury during aortic surgery. It is important for neurosurgeons to have opportunities to see patients with spinal cord ischemia, and to understand ischemic tolerance of the spinal cord as well as the brain...
September 27, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28953045/perioperative-acute-kidney-injury-an-under-recognized-problem
#16
Melanie Meersch, Christoph Schmidt, Alexander Zarbock
The incidence of perioperative acute kidney injury (AKI) is more common than previously recognized, especially in high-risk patients undergoing higher risk procedures. The growing number of patients who develop perioperative AKI is related, in part, to the aging population and increase in the number of individuals with chronic comorbidities, particularly those with premorbid chronic kidney disease. Despite the acceptance of standardization in the definition of AKI, clinicians routinely underdiagnose it and fail to appreciate that it is associated with considerable morbidity and mortality...
August 4, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28951984/remote-ischemic-preconditioning-protects-human-neural-stem-cells-from-oxidative-stress
#17
Ayako Motomura, Mikiko Shimizu, Akira Kato, Kazuya Motomura, Akane Yamamichi, Hiroko Koyama, Fumiharu Ohka, Tomohide Nishikawa, Yusuke Nishimura, Masahito Hara, Tetsuya Fukuda, Yasuhiko Bando, Toshihide Nishimura, Toshihiko Wakabayashi, Atsushi Natsume
In previous clinical trials, we showed that remote ischemic preconditioning (rIPC) reduced myocardial damage in children undergoing treatment for congenital heart defects and postoperative renal failure in patients undergoing abdominal aortic aneurysm surgery. In rabbit experiments, pre-treatment with plasma and plasma dialysate (obtained using 15-kDa cut-off dialysis membrane) from donor rabbits subjected to rIPC similarly protected against cardiac infarction. However, the protective substances containing in rIPC plasma have been unknown...
September 26, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28937253/sirt1-mediates-improvement-in-cognitive-defects-induced-by-focal-cerebral-ischemia-following-hyperbaric-oxygen-preconditioning-in-rats
#18
P Ding, D Ren, S He, M He, G Zhang, Y Chen, H Sang, Z Peng, W Yan
Hyperbaric oxygen preconditioning (HBO-PC) has been proposed as a safe and practical approach for neuroprotection in ischemic stroke. However, it is not known whether HPO-PC can improve cognitive deficits induced by cerebral ischemia, and the mechanistic basis for any beneficial effects remains unclear. We addressed this in the present study using rats subjected to middle cerebral artery occlusion (MCAO) as an ischemic stroke model following HBO-PC. Cognitive function and expression of phosphorylated neurofilament heavy polypeptide (pNF-H) and doublecortin (DCX) in the hippocampus were evaluated 14 days after reperfusion and after short interfering RNA-mediated knockdown of sirtuin1 (Sirt1)...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937044/priming-of-the-cells-hypoxic-preconditioning-for-stem-cell-therapy
#19
REVIEW
Zheng Z Wei, Yan-Bing Zhu, James Y Zhang, Myles R McCrary, Song Wang, Yong-Bo Zhang, Shan-Ping Yu, Ling Wei
OBJECTIVE: Stem cell-based therapies are promising in regenerative medicine for protecting and repairing damaged brain tissues after injury or in the context of chronic diseases. Hypoxia can induce physiological and pathological responses. A hypoxic insult might act as a double-edged sword, it induces cell death and brain damage, but on the other hand, sublethal hypoxia can trigger an adaptation response called hypoxic preconditioning or hypoxic tolerance that is of immense importance for the survival of cells and tissues...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936746/therapeutic-effects-of-ischemic-preconditioned-exosomes-in-cardiovascular-diseases
#20
Shengguang Ding, Zhiqing Fan, Che Lin, Qiying Dai, Jinzhe Zhou, Haitao Huang, Yiming Xu, Chongjun Zhong
Despite years of researches, cardiovascular disease (CVD) remains the most common cause of death around the world. Lots of studies showed that by pretreating with short nonfatal ischemia in in situ organ or distant organ, one could develop tolerance to the following fatal ischemia. The process is called ischemic preconditioning (IPC). IPC prepare the heart for damage by producing inflammatory signals, miRNA, neuro system stimulation and exosomes. Among them, exosomes have been gaining increasing interest since it is characterized by its capability to carry information and its specific ligand-receptor system...
2017: Advances in Experimental Medicine and Biology
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