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Ischemic preconditioning

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https://www.readbyqxmd.com/read/29649974/delayed-and-repeated-intranasal-delivery-of-bone-marrow-stromal-cells-increases-regeneration-and-functional-recovery-after-ischemic-stroke-in-mice
#1
Monica J Chau, Todd C Deveau, Xiaohuan Gu, Yo Sup Kim, Yun Xu, Shan Ping Yu, Ling Wei
BACKGROUND: Stroke is a leading cause of death and disability worldwide, yet there are limited treatments available. Intranasal administration is a novel non-invasive strategy to deliver cell therapy into the brain. Cells delivered via the intranasal route can migrate from the nasal mucosa to the ischemic infarct and show acute neuroprotection as well as functional benefits. However, there is little information about the regenerative effects of this transplantation method in the delayed phase of stroke...
April 12, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29644488/brain-ischemic-preconditioning-protects-against-moderate-not-severe-transient-global-cerebral-ischemic-injury
#2
Jae-Chul Lee, Bich-Na Shin, Jeong Hwi Cho, Tae-Kyeong Lee, In Hye Kim, YooHun Noh, Sung-Su Kim, Hyang-Ah Lee, Young-Myeong Kim, Hyeyoung Kim, Jun Hwi Cho, Joon Ha Park, Ji Hyeon Ahn, Il Jun Kang, In Koo Hwang, Moo-Ho Won, Myoung Cheol Shin
Ischemic preconditioning (IPC) in the brain increases ischemic tolerance to subsequent ischemic insults. In this study, we examined whether IPC protects neurons and attenuates microgliosis or not in the hippocampus following severe transient global cerebral ischemia (TCI) in gerbils. Gerbils were assigned to 8 groups; 5- and 15-min sham operated groups, 5-min and 15-min TCI operated groups, IPC plus 5- and 15-min sham operated groups, and IPC plus 5- and 15-min TCI operated groups. IPC was induced by subjecting animals to 2-min transient ischemia 1 day before 5-min TCI for a typical transient ischemia and 15-min TCI for severe transient ischemia...
April 12, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29623935/neuroprotective-effect-of-ischemic-postconditioning-on-sciatic-nerve-transection
#3
Xiao-Bin Zhou, Na Liu, Dong Wang, De-Xin Zou, Chang-Wei Wei, Jun-Lin Zhou
Ischemic preconditioning or postconditioning has been shown to have neuroprotective effect on cerebral ischemia, but it has not been studied in peripheral nerve injury. In this study, a rat model of sciatic nerve transection was established, and subjected to three cycles of ischemia for 10 minutes + reperfusion for 10 minutes, once a day. After ischemic postconditioning, serum insulin-like growth factor 1 expression increased; sciatic nerve Schwann cell myelination increased; sensory function and motor function were restored...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29622397/the-route-and-timing-of-hydrogen-sulfide-therapy-critically-impacts-intestinal-recovery-following-ischemia-and-reperfusion-injury
#4
Amanda R Jensen, Natalie A Drucker, Jan P Te Winkel, Michael J Ferkowicz, Troy A Markel
PURPOSE: Hydrogen sulfide (H2 S) has many beneficial properties and may serve as a novel treatment in patients suffering from intestinal ischemia-reperfusion injury (I/R). The purpose of this study was to examine the method of delivery and timing of administration of H2 S for intestinal therapy during ischemic injury. We hypothesized that 1) route of administration of hydrogen sulfide would impact intestinal recovery following acute mesenteric ischemia and 2) preischemic H2 S conditioning using the optimal mode of administration as determined above would provide superior protection compared to postischemic application...
March 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29621201/remote-ischemic-preconditioning-does-not-affect-the-release-of-humoral-factors-in-propofol-anesthetized-cardiac-surgery-patients-a-secondary-analysis-of-the-ripheart-study
#5
Julia Ney, Katleen Hoffmann, Patrick Meybohm, Andreas Goetzenich, Sandra Kraemer, Carina Benstöm, Nina C Weber, Johannes Bickenbach, Rolf Rossaint, Gernot Marx, Kai Zacharowski, Jürgen Bernhagen, Christian Stoppe
In contrast to several smaller studies, which demonstrate that remote ischemic preconditioning (RIPC) reduces myocardial injury in patients that undergo cardiovascular surgery, the RIPHeart study failed to demonstrate beneficial effects of troponin release and clinical outcome in propofol-anesthetized cardiac surgery patients. Therefore, we addressed the potential biochemical mechanisms triggered by RIPC. This is a predefined prospective sub-analysis of the randomized and controlled RIPHeart study in cardiac surgery patients ( n = 40) that was recently published...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29617505/evaluation-of-the-effects-of-atorvastatin-and-ischemic-postconditioning-preventing-on-the-ischemia-and-reperfusion-injury-experimental-study-in-rats
#6
Henrique Budib Dorsa Pontes, José Carlos Dorsa Vieira Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, João Victor Cunha Miranda, Letícia do Espírito Santos Dias, João Victor Durães Gomes Oliva, Murilo Henrique Martins de Almeida, Ian de Oliveira Chaves, Tricia Luna Sampaio, Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado
INTRODUCTION: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experimental trials demonstrated that the ischemic postconditioning presents similar effectiveness. Recently experimental trials demonstrated that statins could be used as pharmacological preconditioning...
January 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29607326/ischemic-preconditioning-promotes-autophagy-and-alleviates-renal-ischemia-reperfusion-injury
#7
Ying Xie, Jing Xiao, Chensheng Fu, Zhenxing Zhang, Zhibin Ye, Xiaoli Zhang
Autophagy is important for cellular survival during renal ischemia/reperfusion (I/R) injury. Ischemic preconditioning (IPC) has a strong renoprotective effect during renal I/R. Our study here aimed to explore the effect of IPC on autophagy during renal I/R injury. Rats were subjected to unilateral renal ischemia with or without prior IPC. Hypoxia/reoxygenation (H/R) injury was induced in HK-2 cells with or without prior hypoxic preconditioning (HPC). Autophagy and apoptosis were detected after reperfusion or reoxygenation for different time...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29601806/remote-ischemic-preconditioning-does-not-prevent-white-matter-injury-in-neonates
#8
J William Gaynor, Susan C Nicolson, Diane M Spray, Nancy B Burnham, Jesse L Chittams, Therese Sammarco, Kevin W Walsh, Thomas L Spray, Daniel J Licht
BACKGROUND: Remote ischemic preconditioning (RIPC) is a mechanism to protect tissues from injury during ischemia and reperfusion. We investigated the neuroprotective effects of RIPC in neonates undergoing cardiac surgery. METHODS: The outcome was white matter injury (WMI), assessed by the change in volume of WMI from preoperative to postoperative brain MRI. Subjects were randomized to RIPC or SHAM. RIPC was induced prior to cardiopulmonary bypass by four 5 minute cycles of blood pressure cuff inflation to produce ischemia of the lower extremity...
March 27, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29596325/preconditioning-like-properties-of-short-term-hypothermia-in-isolated-perfused-rat-liver-iprl-system
#9
Norma Alva, Raquel G Bardallo, David Basanta, Jesús Palomeque, Teresa Carbonell
Hypothermia may attenuate the progression of ischemia-induced damage in liver. Here, we determined the effects of a brief cycle of hypothermic preconditioning applied before an ischemic/reperfusion (I/R) episode in isolated perfused rat liver (IPRL) on tissue damage and oxidative stress. Rats (male, 200-250 g) were anaesthetised with sodium pentobarbital (60 mg·kg-1 i.p) and underwent laparatomy. The liver was removed and perfused in a temperature-regulated non-recirculating system. Livers were randomly divided into two groups ( n = 6 each group)...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29581218/ripheart-remote-ischemic-preconditioning-for-heart-surgery-study-myocardial-dysfunction-postoperative-neurocognitive-dysfunction-and-1-year-follow-up
#10
Patrick Meybohm, Madeline Kohlhaas, Christian Stoppe, Matthias Gruenewald, Jochen Renner, Berthold Bein, Martin Albrecht, Jochen Cremer, Mark Coburn, Gereon Schaelte, Andreas Boening, Bernd Niemann, Michael Sander, Jan Roesner, Frank Kletzin, Haitham Mutlak, Sabine Westphal, Rita Laufenberg-Feldmann, Marion Ferner, Ivo F Brandes, Martin Bauer, Sebastian N Stehr, Andreas Kortgen, Maria Wittmann, Georg Baumgarten, Tanja Meyer-Treschan, Peter Kienbaum, Matthias Heringlake, Julika Schoen, Sascha Treskatsch, Thorsten Smul, Ewa Wolwender, Thomas Schilling, Georg Fuernau, Holger Bogatsch, Oana Brosteanu, Dirk Hasenclever, Kai Zacharowski
BACKGROUND: Remote ischemic preconditioning (RIPC) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac surgery patients receiving either RIPC or sham-RIPC. METHODS AND RESULTS: In this follow-up paper, we present 1-year follow-up of the composite primary end point and its individual components (all-cause mortality, myocardial infarction, stroke and acute renal failure), in a sub-group of patients, intraoperative myocardial dysfunction assessed by transesophageal echocardiography and the incidence of postoperative neurocognitive dysfunction 5 to 7 days and 3 months after surgery...
March 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29579594/comparing-cardioprotetion-by-diohf-intervention-and-ischemic-preconditioning
#11
EDITORIAL
Yeong-Renn Chen
No abstract text is available yet for this article.
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29574462/remote-limb-ischemic-preconditioning-attenuates-cerebrovascular-depression-during-sinusoidal-galvanic-vestibular-stimulation-via-%C3%AE-1-adrenoceptor-protein-kinase-c%C3%AE%C2%B5-endothelial-no-synthase-pathway-in-rats
#12
Devin W McBride, Cesar Reis, John H Zhang, Richard Applegate, Jiping Tang
BACKGROUND: Vasovagal syncope (VVS) is characterized by hypotension and bradycardia followed by lowering of cerebral blood flow. Remote limb ischemic preconditioning (RIPC) is well documented to provide cardio- and neuroprotection as well as to improve cerebral blood flow. We hypothesized that RIPC will provide protection against VVS-induced hypotension, bradycardia, and cerebral hypoperfusion. Second, because endothelial nitric oxide synthase has been reported as a mediator of cerebral blood flow control, we hypothesized that the mechanism by which RIPC primes the vasculature against VVS is via the α1 -adrenoceptor-protein kinase Cε-endothelial nitric oxide synthase pathway...
March 24, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29573617/anti-arrhythmogenic-and-anti-inflammatory-effects-of-troxerutin-in-ischemia-reperfusion-injury-of-diabetic-myocardium
#13
Moslem Najafi, Elham Noroozi, Aniseh Javadi, Reza Badalzadeh
INTRODUCTION: Medicinal plants are increasingly used in the treatment of cardiovascular diseases due to their multifaceted properties. This study was designed to investigate anti-arrhythmic and anti-inflammatory potentials of the natural bioflavonoid, troxerutin (TXR) in myocardial ischemia/reperfusion (I/R) injury in diabetic rats. METHODS: Male Wistar rats were randomly divided into 4 groups (control, control + TXR [150 mg/kg, daily], diabetic, and diabetic + TXR)...
March 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29568969/mir%C3%A2-133b%C3%A2-5p-contributes-to-hypoxic-preconditioning%C3%A2-mediated-cardioprotection-by-inhibiting-the-activation-of-caspase%C3%A2-8-and-caspase-3-in-cardiomyocytes
#14
Yong-Lu Pan, Zheng-Yi Han, Shu-Fang He, Wan Yang, Jie Cheng, Ye Zhang, Zhi-Wu Chen
In a previous study using a microRNA (miRNA/miR) microarray assay, we demonstrated that miR-133b-5p was upregulated in response to hypoxic preconditioning (HPC). The present study was designed to investigate the role of the miR‑133b‑5p in HPC‑induced cardioprotection and the underlying mechanisms involving caspase‑8 and caspase‑3 apoptotic signaling. Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured...
March 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29562750/inhibition-of-na-h-exchanger-with-emd-87580-does-not-confer-greater-cardioprotection-beyond-preconditioning-on-ischemia-reperfusion-injury-in-normal-dogs
#15
J G Kingma
Postischemic accumulation of intracellular Na+ promotes calcium overload and contributes to cellular necrosis. Cardioprotection afforded by pharmacologic blockade of the sodium-hydrogen exchanger subtype 1 (NHE1) is thought to be more remarkable than that obtained by ischemic conditioning (IC). The window of protection provided by IC pretreatment is maintained even when performed up to 48 hours before ischemia. In addition, the perception exists that combined NHE1 inhibition plus IC produces greater than additive protection against ischemic injury...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29551926/effect-of-total-flavonoid-in-rabdosia-rubescens-on-tolerant-mice-models-under-cerebral-anoxia
#16
Le Kang, Mingsan Miao, Ming Bai, Shuo Tian
Objective: To study the protective effect of total flavonoid in rabdosia rubescens on BIT model by brain ischemic tolerance (hereinafter BIT) model of mice. Method: BIT model is used to block bilateral common carotid arteries and to copy BIT model of mice. After 10 min of transient ischemia for rats in preconditioning group, the mice in the nimodipine group and naoluotong capsule group were given the total flavonoid in rabdosia rubescens (300 mg/kg, 150 mg/kg, 75 mg/kg) for gavage, sham operation group, ischemia/reperfusion injury (hereinafter IRI) group and BIT group were fed with the same volume of 0...
December 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29549046/shear-stress-an-essential-driver-of-endothelial-progenitor-cells
#17
REVIEW
Anton G Kutikhin, Maxim Yu Sinitsky, Arseniy E Yuzhalin, Elena A Velikanova
The blood flow through vessels produces a tangential, or shear, stress sensed by their innermost layer (i.e., endothelium) and representing a major hemodynamic force. In humans, endothelial repair and blood vessel formation are mainly performed by circulating endothelial progenitor cells (EPCs) characterized by a considerable expression of vascular endothelial growth factor receptor 2 (VEGFR2), CD34, and CD133, pronounced tube formation activity in vitro, and strong reendothelialization or neovascularization capacity in vivo...
March 13, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29547418/propofol-anesthesia-and-remote-ischemic-preconditioning-an-unfortunate-relationship
#18
Jan Rossaint
No abstract text is available yet for this article.
April 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29533954/repeated-non-invasive-limb-ischemic-preconditioning-confers-cardioprotection-through-pkc-%C3%B4-stat3-signaling-in-diabetic-rats
#19
Chunyan Wang, Haobo Li, Sheng Wang, Xiaowen Mao, Dan Yan, Stanley S Wong, Zhengyuan Xia, Michael G Irwin
BACKGROUND/AIMS: Protein kinase C(PKC)-ε activation is a mechanism of preconditioning cardioprotection but its role in repeated non-invasive limb ischemic preconditioning (rNLIP) mediated cardioprotection against myocardial ischemia/reperfusion (I/R) injury in diabetes is unknown. METHODS: Eight-week streptozotocin-induced diabetic and non-diabetic Sprague-Dawley rats were subjected to I/R without or with rNLIP. In vitro, H9C2 cells were cultured with high glucose (HG) and subjected to hypoxia/re-oxygenation (H/R) without or with PKC-ε or STAT3 gene knock-down in the absence or presence of remote time hypoxia preconditioning (HPC)...
March 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29524006/remote-ischemic-preconditioning-fails-to-reduce-infarct-size-in-the-zucker-fatty-rat-model-of-type-2-diabetes-role-of-defective-humoral-communication
#20
Joseph Wider, Vishnu V R Undyala, Peter Whittaker, James Woods, Xuequn Chen, Karin Przyklenk
Remote ischemic preconditioning (RIPC), the phenomenon whereby brief ischemic episodes in distant tissues or organs render the heart resistant to infarction, has been exhaustively demonstrated in preclinical models. Moreover, emerging evidence suggests that exosomes play a requisite role in conveying the cardioprotective signal from remote tissue to the myocardium. However, in cohorts displaying clinically common comorbidities-in particular, type-2 diabetes-the infarct-sparing effect of RIPC may be confounded for as-yet unknown reasons...
March 9, 2018: Basic Research in Cardiology
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