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Ischemic preconditioning

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https://www.readbyqxmd.com/read/29467715/limb-remote-ischemic-conditioning-mechanisms-anesthetics-and-the-potential-for-expanding-therapeutic-options
#1
REVIEW
Gangling Chen, Mrugesh Thakkar, Christopher Robinson, Sylvain Doré
Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29454673/remote-ischemic-preconditioning-a-complex-question-with-an-even-more-complex-answer
#2
EDITORIAL
Sarah A Schubert, Irving L Kron
No abstract text is available yet for this article.
February 15, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29451211/electroacupuncture-preconditioning-protects-against-focal-cerebral-ischemia-reperfusion-injury-via-suppression-of-dynamin-related-protein-1
#3
Gao-Feng Zhang, Pei Yang, Zeng Yin, Huai-Long Chen, Fu-Guo Ma, Bin Wang, Li-Xin Sun, Yan-Lin Bi, Fei Shi, Ming-Shan Wang
Electroacupuncture preconditioning at acupoint Baihui (GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1 (Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20 (depth 2 mm, intensity 1 mA, frequency 2/15 Hz, for 30 minutes, once a day)...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29448100/post-ischemic-administration-of-5-methoxyindole-2-carboxylic-acid-at-the-onset-of-reperfusion-affords-neuroprotection-against-stroke-injury-by-preserving-mitochondrial-function-and-attenuating-oxidative-stress
#4
Jinzi Wu, Zhen Jin, Xiaorong Yang, Liang-Jun Yan
We previously reported that 5-methoxyindole-2-carboxylic acid (MICA) could induce preconditioning effect in the ischemic brain of rat. In the present study, we addressed the question of whether MICA could also trigger a postconditioning effect in ischemic stroke. To this end, MICA (100mgkg body weight) was injected intraperitoneally at the onset of 24 h reperfusion following 1 h ischemia in rat brain. Results indicate that stroked animals treated with MICA showed less brain infarction volume than that of vehicle-treated animals...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29446730/salvaging-the-ischemic-heart-gi-coupled-receptors-in-mast-cells-activate-a-pkc%C3%AF-aldh2-pathway-providing-anti-ras-cardioprotection
#5
Alice Marino, Roberto Levi
BACKGROUND: Excessive norepinephrine (NE) release in the ischemic heart elicits severe and often lethal arrhythmias. Resident cardiac mast cells synthesize and store active renin, which is released upon degranulation, causing the activation of a local cardiac renin-angiotensin system (RAS) responsible for NE release and consequent arrhythmias. Toxic aldehydes, known to be formed by lipid peroxidation in ischemia/reperfusion (I/R), have been shown to degranulate mast cells and activate a local RAS...
February 13, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29438409/the-effect-of-transient-oxygenation-on-stem-cell-mobilization-and-ischemia-reperfusion-heart-injury
#6
Rintaro Yano, Chiaki Inadomi, Lan Luo, Shinji Goto, Tetsuya Hara, Tao-Sheng Li
For general anesthesia, pre-oxygenation is routinely performed prior to intubation. It is well-known that ischemic/hypoxic preconditioning induces stem cell mobilization and protects against ischemia/reperfusion (I/R) injury. In this study, we investigated the effect of transient oxygenation on stem cell mobilization and I/R injury of the heart. Mice were exposed to 100% oxygen for 5 or 20 minutes. We evaluated the number of c-kit+ stem/progenitor cells and the levels of SDF-1α and VEGF in peripheral blood at 1, 3, 6, and 24 hours after oxygenation...
2018: PloS One
https://www.readbyqxmd.com/read/29431194/neuronal-like-differentiated-sh-sy5y-cells-adaptation-to-a-mild-and-transient-h2-o2-induced-oxidative-stress
#7
Rachid Akki, Rosalba Siracusa, Rossana Morabito, Alessia Remigante, Michela Campolo, Mohammed Errami, Giuseppina La Spada, Salvatore Cuzzocrea, Angela Marino
Preconditioning (PC) is a cell adaptive response to oxidative stress and, with regard to neurons, can be considered as a neuroprotective strategy. The aim of the present study was to verify how neuronal-like differentiated SH-SY5Y cells adapt to a mild and transient H2 O2 -induced oxidative stress and, hence, whether may be considered as more sensitive cell model to study PC pathways. A first screening allowed to define H2 O2 concentrations for PC (10μM-50μM), applied before damage(100μM H2 O2 ). Cell viability measured 24 hours after 100μM H2 O2 -induced damage was ameliorated by 24-hour pre-exposure to low-concentration H2 O2 (10μM-30μM) with cell size as well restored...
February 12, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29430406/effect-of-remote-ischemic-preconditioning-on-troponin-i-in-cabg
#8
Fatemeh Javaherforoosh Zadeh, Mohsen Moadeli, Mansoor Soltanzadeh, Farahzad Janatmakan
Background: Elective open heart surgery is associated with troponin release in some cases due to myocyte necrosis. Objectives: The aim of this study was to measure cardiac troponin I (cTnI) preoperatively in elective CABG after remote ischemic preconditioning. Methods: Twenty-eight patients were selected for elective CABG. They were randomized to receive remote ischemic preconditioning (induced by three 5-min cycles of inflation with a pneumatic tourniquet and 5-min deflation between inflation episodes as reperfusion)...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29429928/effect-of-remote-ischemic-preconditioning-on-intestinal-ischemia-reperfusion-injury-in-adults-undergoing-on-pump-cabg-surgery-a-randomized-controlled-pilot-trial
#9
Rafael Struck, Maria Wittmann, Stefan Müller, Patrick Meybohm, Andreas Müller, Soyhan Bagci
OBJECTIVE: Cardiopulmonary bypass (CPB) surgery commonly threatens the heart and remote organs with ischemia-reperfusion injury. Transient episodes of ischemia to nonvital tissue, known as remote ischemic preconditioning (RIPC), is thought to help local and remote vital organs to withstand subsequent ischemic insults. DESIGN: Prospective, randomized, double-blinded control trial. SETTING: Tertiary referral academic teaching hospital. PARTICIPANTS: Thirty patients undergoing elective CPB surgery INTERVENTION: RIPC was achieved via three 5-minute cycles of upper limb ischemia using a blood pressure cuff or control (sham cuff)...
July 27, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29427321/effects-of-sevoflurane-preconditioning-on-microglia-macrophage-dynamics-and-phagocytosis-profile-against-cerebral-ischemia-in-rats
#10
Dan-Dan Dang, Hexige Saiyin, Qiong Yu, Wei-Min Liang
AIM: The effects of sevoflurane on microglia/macrophages, promoting or suppressing their activation, remains controversy. We aimed to determine whether sevoflurane preconditioning can protect brain via changing microglia/macrophage dynamics and phagocytosis profile after ischemia. METHODS: The impact of sevoflurane preconditioning was evaluated on microglia/macrophage migration, phagocytosis and proliferation altogether from day 1 to day 7 after transient middle cerebral arterial occlusion (tMCAO) in rats...
February 9, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29419572/preconditioning-and-postconditioning-by-cardiac-glycosides-in-the-mouse-heart
#11
Qiming Duan, Yunhui Xu, Pauline V Marck, Jennifer Kalisz, Eric E Morgan, Sandrine V Pierre
Ouabain preconditioning (OPC) initiated by low concentrations of the cardiac glycoside (CG) ouabain binding to Na/K-ATPase is relayed by a unique intracellular signaling and protects cardiac myocytes against ischemia/reperfusion injury. To explore more clinically applicable protocols based on CG properties, we tested whether the FDA-approved CG digoxin could trigger cardioprotective effects comparable with those of ouabain using PC, preconditioning and PostC, postconditioning protocols in the Langendorff-perfused mouse heart subjected to global ischemia and reperfusion...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29389691/the-effect-of-ischemic-preconditioning-on-maximal-swimming-performance
#12
N Williams, M Russell, C J Cook, L P Kilduff
The effect of ischemic preconditioning (IPC) on swimming performance was examined. Using a randomized, crossover design, National-and International-level swimmers (n=20; 14 males, 6 females) participated in three trials (Con, IPC-2h, IPC-24h). Lower-body IPC (4 x 5 min bi-lateral blood-flow restriction at 160-228 mmHg, and 5 min reperfusion) was used 2- (IPC-2h) or 24-h (IPC-24h) before a self-selected (100 m, n=15; 200 m, n=5) swimming time-trial (TT). The Con trial used a sham intervention (15 mmHg) 2h prior to exercise...
January 30, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29385043/interplay-between-ros-and-antioxidants-during-ischemia-reperfusion-injuries-in-cardiac-and-skeletal-muscle
#13
REVIEW
Tingyang Zhou, Evan R Prather, Davis E Garrison, Li Zuo
Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR injury in striated muscles involve the production of reactive oxygen species (ROS). Excessive ROS accumulation results in cellular oxidative stress, mitochondrial dysfunction, and initiation of cell death by activation of the mitochondrial permeability transition pore. Elevated ROS levels can also decrease myofibrillar Ca2+ sensitivity, thereby compromising muscle contractile function...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29383886/-effect-of-electroacupuncture-and-moxibustion-pretreatment-on-expression-of-autophagy-related-proteins-lc-3-and-beclin-1-in-rats-with-myocardial-ischemia-reperfusion-injury
#14
Cheng-Fu Tan, Chao Wang, Lin Du, Wei-Wei Liu, Jin Song, Guo Feng, Jie Yan, Jing-Jing Yang, Ya-Ni Tang, Mei-Lin Chen, Jiao-Lan Li
OBJECTIVE: To observe the effect of electroacupuncture (EA) and moxibustion (Moxi) pretreatment on myocardial pathological and structural changes and expression of autophagy related protein LC 3 Ⅰ/Ⅱ and Beclin 1 in rats with myocardial ischemia-reperfusion injury (MI/RI), so as to explore their mechanisms underlying improving MI/RI. METHODS: Forty SD rats were randomly divided into sham operation, model, ischemic preconditioning (IP), EA and Moxi groups (n=8 in each group)...
January 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29383108/sevoflurane-preconditioning-promotes-activation-of-resident-cscs-by-transplanted-bmscs-via-mir-210-in-a-rat-model-for-myocardial-infarction
#15
Ti Wen, Li Wang, Xue-Jun Sun, Xi Zhao, Guang-Wei Zhang, Jesse Li-Ling
Objective: To assess the effect of sevoflurane preconditioning (SFpre) on bone marrow mesenchymal stem cells (BMSCs) for the treatment of acute myocardial infarction. Results: 24 hours after the transplantation, decreased apoptosis of implanted BMSCs and up-regulation of cytokines expression were found within the ischemic area inSFpre BMSCs group compared with BMSCs group ( P < 0.05). 4 weeks later,SFpre BMSCs group showed more viable implanted BMSCs, CSC-derived cardiomyocytes, and higher vessel and myocardial density within the infarcted region and improved cardiac function, compared with control and BMSCs groups ( P < 0...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29374605/an-experimental-study-on-repeated-brief-ischemia-in-promoting-sciatic-nerve-repair-and-regeneration-in-rats
#16
Xiao-Bin Zhou, De-Xin Zou, Wei Gu, Dong Wang, Jian-Shu Feng, Jiang-Yong Wang, Jun-Lin Zhou
BACKGROUND: Researches have shown that ischemic preconditioning reduced the severity of ischemia-reperfusion injury in brain in rats, we have a hypothesis that repeated brief ischemia has positive effects on peripheral nerve damage. AIM: This study was conducted to investigate the potential protective effects of repeated brief ischemia on peripheral nerve regeneration using a rat model of experimental sciatic nerve transection injury. METHOD: Treatment groups (group A-D) received repeated brief ischemia every one day/two days/three days/7 days...
January 25, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29373843/ros-and-redox-signaling-in-myocardial-ischemia-reperfusion-injury-and-cardioprotection
#17
REVIEW
Susana Cadenas
Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases, such as stroke and myocardial infarction. IR injury is mediated by several factors including the elevated production of reactive oxygen species (ROS), which occurs particularly at reperfusion. The mitochondrial respiratory chain and NADPH oxidases of the NOX family are major sources of ROS in cardiomyocytes. The first part of this review discusses recent findings and controversies on the mechanisms of superoxide production by the mitochondrial electron transport chain during IR injury, as well as the contribution of the NOX isoforms expressed in cardiomyocytes, NOX1, NOX2 and NOX4, to this damage...
January 23, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29371613/the-mdm2-p53-pathway-is-involved-in-preconditioning-induced-neuronal-tolerance-to-ischemia
#18
Rebeca Vecino, Maria C Burguete, Teresa Jover-Mengual, Jesus Agulla, Verónica Bobo-Jiménez, Juan B Salom, Angeles Almeida, Maria Delgado-Esteban
Brain preconditioning (PC) refers to a state of transient tolerance against a lethal insult that can be evoked by a prior mild event. It is thought that PC may induce different pathways responsible for neuroprotection, which may involve the attenuation of cell damage pathways, including the apoptotic cell death. In this context, p53 is a stress sensor that accumulates during brain ischemia leading to neuronal death. The murine double minute 2 gene (MDM2), a p53-specific E3 ubiquitin ligase, is the main cellular antagonist of p53, mediating its degradation by the proteasome...
January 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29371417/exogenous-gene-transmission-of-isocitrate-dehydrogenase-2-mimics-ischemic-preconditioning-protection
#19
Alexander L Kolb, Peter R Corridon, Shijun Zhang, Weimin Xu, Frank A Witzmann, Jason A Collett, George J Rhodes, Seth Winfree, Devin Bready, Zechariah J Pfeffenberger, Jeremy M Pomerantz, Takashi Hato, Glenn T Nagami, Bruce A Molitoris, David P Basile, Simon J Atkinson, Robert L Bacallao
Ischemic preconditioning confers organ-wide protection against subsequent ischemic stress. A substantial body of evidence underscores the importance of mitochondria adaptation as a critical component of cell protection from ischemia. To identify changes in mitochondria protein expression in response to ischemic preconditioning, we isolated mitochondria from ischemic preconditioned kidneys and sham-treated kidneys as a basis for comparison. The proteomic screen identified highly upregulated proteins, including NADP+-dependent isocitrate dehydrogenase 2 (IDH2), and we confirmed the ability of this protein to confer cellular protection from injury in murine S3 proximal tubule cells subjected to hypoxia...
January 25, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29368759/ischemic-preconditioning-treatment-of-astrocytes-transfers-ischemic-tolerance-to-neurons
#20
Srinivasan V Narayanan, Miguel A Perez-Pinzon
Ischemic preconditioning (IPC) represents a potential therapy against cerebral ischemia. While our group has previously shown IPC to induce neuroprotection through various pathways, the role of astrocytes in supporting IPC-induced neuroprotection has not been extensively studied. Astrocyte-derived lactate has gained attention as a potential soluble mediator through which astrocytes could impart ischemic tolerance to neurons. Therefore, the goal of this study was to determine if i) IPC-treatment of astrocytes alone could transfer ischemic tolerance to neurons; ii) if IPC-treatment of astrocytes increases lactate production; and if iii) exogenous lactate administration to neurons could induce neuroprotection against lethal ischemia in vitro...
December 2017: Cond Med
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