pCOP

Pesticide detection and monitoring are necessary for human health as the overapplication has serious consequences for environmental pollution. Herein, a proper modulation strategy was implemented to construct the photostimulus-responsive peptide-dot-centered covalent organic polymer (P-PCOP) nanoarchitecture for selective sensing of pesticides. The as-constructed P-PCOP was prepared at room temperature by using amino-containing peptide dots as a building block instead of common organic molecules, and the merits of P-PCOP enable it to reduce the steric hindrance of recognition, enhance the interfacial contact of the target, and facilitate the accessibility of sites, which promises to improve the sensitivity...

Cryptogenic organizing pneumonia (COP) is a form of idiopathic interstitial pneumonia that commonly presents with exertional dyspnea. The mainstay diagnostic criterion is with histopathological confirmation alongside excluding secondary causes of interstitial lung disease. The COVID-19 pandemic left many mysteries regarding the long-term sequelae of this disease. We explore a case of post-COVID-19 syndrome organizing pneumonia (PCOP) in a patient presenting with new-onset respiratory symptoms seven weeks after recovery from COVID-19 infection...

Herein, we synthesized a novel porphyrinic covalent organic polymer (TPAPP-PTCA PCOP) for constructing a polarity-switchable dual-wavelength photoelectrochemical (PEC) biosensor with ferrocene (Fc) and hydrogen peroxide (H2 O2 ) as regulator and amplifier simultaneously. Interestingly, this new PCOP possessed both n-type and p-type semiconductor characteristics, which thus enabled the appearance of a dual-polarity photocurrent at two different excitation wavelengths. Furthermore, Fc and H2 O2 could readily switch the photocurrent of PCOP to the cathode and anode stemming from its efficient electron collection and donation function, respectively...

The ladder phenyl/vinyl polysilsesquioxane (PhVPOSS) was used to improve the flame-retardancy performances of ethylene-vinyl acetate copolymer (EVA)/aluminum hydroxide (ATH) composites due to the reactivity of its vinyl groups. FTIR, XPS, 1 H NMR, and SEM-EDS data demonstrated the PhVPOSS grafting onto EVA molecular chains. The PhVPOSS improved the thermal stability of EVA/ATH composites, as shown by the thermogravimetric analysis (TGA). Furthermore, with the cone calorimeter (CONE) experiments, EVA/ATH/PhVPOSS showed better fire safety than the EVA/ATH composites, with the PHRR, PSPR, and PCOP reduced by 7...

To alleviate the fire hazard of epoxy resin (EP), layered ammonium vanadium oxalate-phosphate (AVOPh) with the structural formula of (NH4 )2 [VO(HPO4 )]2 (C2 O4 )·5H2 O is synthesized using the hydrothermal method and mixed into an EP matrix to prepare EP/AVOPh composites. The thermogravimetric analysis (TGA) results show that AVOPh exhibits a similar thermal decomposition temperature to EP, which is suitable for flame retardancy for EP. The incorporation of AVOPh nanosheets greatly improves the thermal stability and residual yield of EP/AVOPh composites at high temperatures...

The Junggar Basin in Xinjiang is located in the hinterland of Eurasia, where the groundwater is a significant resource and has important ecological functions. The introduction of harmful organic pollutants into groundwater from increasing human activities and rapid socioeconomic development may lead to groundwater pollution at various levels. Therefore, to develop an effective regulatory framework, establishing a list of priority control organic pollutants (PCOPs) is in urgent need. In this study, a method of ranking the priority of pollutants based on their prevalence ( Pv ), occurrence ( O ) and persistent bioaccumulative toxicity ( PBT ) has been developed...

Since the beginning of the COVID-19 pandemic, clinical, radiological, and histopathological studies have provided evidence that organizing pneumonia is a possible consequence of the SARS-CoV2 infection. This post-COVID-19 organizing pneumonia (PCOP) causes persisting dyspnea, impaired pulmonary function, and produces radiological abnormalities for at least 5 weeks after onset of symptoms. While most patients with PCOP recover within a year after acute COVID-19, 5-25% of cases need specialized treatment. However, despite substantial resources allocated worldwide to finding a solution to this problem, there are no approved treatments for PCOP...

BACKGROUND: Adults aged 80 years and older form a vulnerable group regarding perceived ageism, because they are often stereotyped as being frail and dependent. Nurses often display biased behaviour and hold negative attitudes towards this age group, due to the fact that they have frequent contact with patients who need complex care. As this frequent contact can negatively influence the quality of care, we performed this study to assess nurses' attitudes towards adults aged 80 and older and their views regarding their care, as well as to identify factors that influence attitudes...

Propylparaben (PrP) has attracted extensive concerns due to its wide occurrence in wastewater and potential health risk. Herein, nitrogen vacancy engineered reticulate g-C3 N4 (Nv-RCN) was successfully synthesized for the photodegradation of PrP. Nv-RCN exhibited larger specific surface area, greater light absorption ability, higher transfer and separation efficiency of charge carriers in comparison with bulk g-C3 N4 (CN). According to the characterization results and DFT calculation, nitrogen vacancy could capture electrons and facilitate oxygen adsorption...

OBJECTIVE: Multidisciplinary Pain Clinics have an established role in the management of persistent pain, however there is little evidence to support this approach in an older population. This study describes the characteristics and pain outcomes of patients attending a pain clinic designed exclusively for older people. METHODS: Retrospective audit of outcomes of the Pain Clinic for Older People (PCOP) from 2015-2019. Response to treatment was determined by change in Brief Pain Inventory scores (BPI) at initial attendance and following a treatment program...

The anticancer effect of photodynamic therapy (PDT) is usually impeded by the hypoxia microenvironment in solid tumors; thus, it requires integration with other treatment tactics to achieve an optimal anticancer efficacy. Porphyrin-containing nanotherapeutic agents are broadly used for PDT in tumor treatment. However, chemodynamic therapy (CDT) of porphyrin-based namomaterials has been rarely reported. Here, a novel nanoscale porphyrin-containing covalent organic polymer (PCOP) was designed by the cross-linking of 5,10,15,20-tetrakis(4-aminophenyl)porphyrin with 1,1'-ferrocenedicarboxylic acid at room temperature...

OBJECTIVE: Recombinant human albumin (rHA) is an alternative to human serum albumin (HSA) for treating ascites in cirrhosis patients. This study was to evaluate the safety, tolerability, immunogenicity, and pharmacokinetics/pharmacodynamics (PK/PD) of rHA in healthy subjects to guide the design for further clinical trials. METHODS: Healthy subjects aged 18-55 years were enrolled in this double-blinded, first-in-human, placebo-controlled single ascending dose (SAD) (1...

The presence of marine pollution in Cartagena Bay (Colombia) is an alarming environmental issue because of the ecotoxicological properties of contaminants such as polycyclic aromatic hydrocarbons (PAHs) that may affect the biodiversity of coastal ecosystems. In this sense, there is a need to propose alternatives to remediate the environmental pollution of such bodies of water. The aim of this work was to design an adsorption-based treatment process for the removal of PAHs from seawater and sediments. Two design cases were considered: (i) a base process without a PAH desorption unit and (ii) an alternative process including a PAH desorption unit...

Due to the unique two-dimensional structure and features of graphitic carbon nitride (g-C3 N4 ), such as high thermal stability and superior catalytic property, it is considered to be a promising flame retardant nano-additive for polymers. Here, we reported a facile strategy to prepare cobalt/phosphorus co-doped graphitic carbon nitride (Co/P-C3 N4 ) by a simple and scalable thermal decomposition method. The structure of Co/P-C3 N4 was confirmed by scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS)...

The past decade has seen considerable innovation in the delivery of care and payment in oncology. Key initiatives have included the development of oncology medical home care delivery standards, the Medicare Oncology Care Model, and multiple commercial payer initiatives. Looking forward, our next challenge is to reflect on lessons learned from these limited-scale demonstration projects and work toward models that are scalable and sustainable and reflect true collaboration between payers and providers sharing common objectives and methods to advance cancer care delivery...

PURPOSE: Efforts to curb the rising costs of cancer care while improving quality include alternative payment models (APMs), which offer incentives to reduce avoidable spending and provide high-quality and cost-efficient care. The impact of proposed APMs has not been quantified in real-world practice. In this study, we evaluated ASCO's Patient-Centered Oncology Payment (PCOP) model in existing fee-for-service (FFS) Medicare beneficiaries to understand the magnitude of potential cost savings...

In this study, a life cycle assessment (LCA) was used to investigate the environmental benefits of using styrene-butadiene-styrene (SBS) to modify polylactide (PLA)-based wood plastic composites (WPCs), with a process-based and input-output hybrid model. The results showed that one metric ton of the SBS-modified WPCs required 1.93 × 108 kJ of energy (Sample 2) and 46 m3 of water (Sample 4), and that it could produce 42.3 kg of solid waste (Sample 2) during its cradle-to-gate life cycle phases. The environmental impact load (EIL) and photochemistry oxidation potential (PCOP) accounted for the largest share, while the eutrophication potential (EP) took the smallest one...

Photodynamic therapy (PDT) of cancers is usually inefficient due to the relatively low level of oxygen in cancer cells; therefore, it needs to combine with other treatment strategies such as chemotherapy or photothermal therapy (PTT) to achieve the best anticancer efficacy. Although porphyrin-containing materials have been widely studied for PDT, the photothermal effect is rarely reported. Herein, nanoscale porphyrin-containing covalent organic polymers (PCOPs) were produced via a room temperature solution-based aging method...

AIM: The purpose of these studies was to determine the reliability and validity of the 24 item Perspectives on Caring for Older Patients (PCOP) scale and further develop the scale as a useful tool for measuring nurses' perspectives toward caring for older patients. BACKGROUND: Ageism has long been an issue in the U.S. as well as globally and is reflected in the attitudes of nurses caring for older patients. Most research in this area utilizes scales that measure attitudes toward older adults or aging in general which is different from how nurses feel about caring for older patients...

Nano-Sb₂O₃ has excellent synergistic flame-retardant effects. It can effectively improve the comprehensive physical and mechanical properties of composites, reduce the use of flame retardants, save resources, and protect the environment. In this work, nanocomposites specimens were prepared by the melt-blending method. The thermal stability, mechanical properties, and flame retardancy of a nano-Sb₂O₃⁻brominated epoxy resin (BEO)⁻poly(butylene terephthalate) (PBT) composite were analyzed, using TGA and differential scanning calorimetry (DSC), coupled with EDX analysis, tensile testing, cone calorimeter tests, as well as scanning electron microscopy (SEM) and flammability tests (limiting oxygen index (LOI), UL94)...