Xiaoyu Liu, Zhen Wan, Ke Chen, Yuxing Yan, Xuyan Li, Yili Wang, Miaoyu Wang, Ruoli Zhao, Jiahui Pei, Lijie Zhang, Si Sun, Jiarong Li, Xinzhu Chen, Qi Xin, Shaofang Zhang, Shuangjie Liu, Hao Wang, Changlong Liu, Xiaoyu Mu, Xiao-Dong Zhang
Excessive accumulation of reduced nicotinamide adenine dinucleotide (NADH) within biological organisms is closely associated with many diseases. It remains a challenge to efficiently convert superfluous and detrimental NADH to NAD+ . NADH oxidase (NOX) is a crucial oxidoreductase that catalyzes the oxidation of NADH to NAD+ . Herein, M1 M2 (M i =V/Mn/Fe/Co/Cu/Mo/Rh/Ru/Pd, i = 1 or 2) mated-atom nanozymes (MANs) are designed by mimicking natural enzymes with polymetallic active centers. Excitingly, RhCo MAN possesses excellent and sustainable NOX-like activity, with K m-NADH (16...
April 15, 2024: Nano Letters