keyword
MENU ▼
Read by QxMD icon Read
search

Niacin amide OR Nicotinamide

keyword
https://www.readbyqxmd.com/read/29502054/-changes-of-cerebral-cortical-metabolomics-in-rats-following-benzo-a-pyrene-exposure
#1
Jing Wang, Chun-Lin Li, Lu-Lu Bai, Qiang-Hu Tang, Rui-Yuan Zhang, Ting-Li Han, Yu-Ming Guo, Philip N Baker, Yin-Yin Xia, Bai-Jie Tu
OBJECTIVE: To analyze the changes in endogenous small molecule metabolites after benzo[a]pyrene (B[a]P) exposure in rat cerebral cortex and explore the mechanism of B[a]P neurotoxicity. METHODS: Five-day-old SD rats were subjected to gavage administration of 2 mg/kg B[a]P for 7 consecutive weeks. After the exposure, the rats were assessed for spatial learning ability using Morris water maze test, ultrastructural changes of the cortical neurons under electron microscope, and metabolite profiles of the cortex using GC/MS...
February 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29477227/niacin
#2
James B Kirkland, Mirella L Meyer-Ficca
Nicotinic acid and nicotinamide, collectively referred to as niacin, are nutritional precursors of the bioactive molecules nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD and NADP are important cofactors for most cellular redox reactions, and as such are essential to maintain cellular metabolism and respiration. NAD also serves as a cosubstrate for a large number of ADP-ribosylation enzymes with varied functions. Among the NAD-consuming enzymes identified to date are important genetic and epigenetic regulators, e...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29468817/urinary-excretion-of-niacin-metabolites-in-humans-after-coffee-consumption
#3
Jonathan Isaak Kremer, Katharina Gömpel, Tamara Bakuradze, Gerhard Eisenbrand, Elke Richling
SCOPE: Coffee is a major natural source of niacin in the human diet, as it is formed during coffee roasting from the alkaloid trigonelline. The intention of our study was to monitor the urinary excretion of niacin metabolites after coffee consumption under controlled diet. METHODS AND RESULTS: We performed a four-day human intervention study on the excretion of major niacin metabolites in the urine of volunteers after ingestion of 500 mL regular coffee containing 34...
February 21, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29432020/sabre-relay-a-versatile-route-to-hyperpolarization
#4
Soumya S Roy, Kate Appleby, Elizabeth Fear, Simon B Duckett
Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H2) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine and pyrazine). The substrate then reacts reversibly with [Pt(OTf)2(bis-diphenylphosphinopropane)] by displacing OTf- to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The 31P NMR signals of these metal complexes prove to be enhanced when the substrate possesses an accessible singlet state or long-lived Zeeman polarization...
February 12, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29404461/cat-2003-a-novel-sterol-regulatory-element-binding-protein-inhibitor-that-reduces-steatohepatitis-plasma-lipids-and-atherosclerosis-in-apolipoprotein-e-3-leiden-mice
#5
Michael Zimmer, Pradeep Bista, Ericka L Benson, Diana Y Lee, Feng Liu, Dominic Picarella, Rick B Vega, Chi B Vu, Maisy Yeager, Min Ding, Guosheng Liang, Jay D Horton, Robert Kleemann, Teake Kooistra, Martine C Morrison, Peter Y Wielinga, Jill C Milne, Michael R Jirousek, Andrew J Nichols
CAT-2003 is a novel conjugate of eicosapentaenoic acid (EPA) and niacin designed to be hydrolyzed by fatty acid amide hydrolase to release EPA inside cells at the endoplasmic reticulum. In cultured liver cells, CAT-2003 blocked the maturation of sterol regulatory element-binding protein (SREBP)-1 and SREBP-2 proteins and decreased the expression of multiple SREBP target genes, including HMGCR and PCSK9 . Consistent with proprotein convertase subtilisin/kexin type 9 (PCSK9) reduction, both low-density lipoprotein receptor protein at the cell surface and low-density lipoprotein particle uptake were increased...
June 2017: Hepatology communications
https://www.readbyqxmd.com/read/29212824/targeted-microbiome-intervention-by-microencapsulated-delayed-release-niacin-beneficially-affects-insulin-sensitivity-in-humans
#6
Daniela Fangmann, Eva-Maria Theismann, Kathrin Türk, Dominik M Schulte, Isabelle Relling, Katharina Hartmann, Julia K Keppler, Jörg-Rainer Knipp, Ateequr Rehman, Femke-Anouska Heinsen, Andre Franke, Lennart Lenk, Sandra Freitag-Wolf, Esther Appel, Stanislav Gorb, Charles Brenner, Dirk Seegert, Georg H Waetzig, Philip Rosenstiel, Stefan Schreiber, Karin Schwarz, Matthias Laudes
OBJECTIVE: Gut microbiota represent a potential novel target for future prediabetes and type 2 diabetes therapies. In that respect, niacin has been shown to beneficially affect the host-microbiome interaction in rodent models. RESEARCH DESIGN AND METHODS: We characterized more than 500 human subjects with different metabolic phenotypes regarding their niacin (nicotinic acid [NA] and nicotinamide [NAM]) status and their gut microbiome. In addition, NA and NAM delayed-release microcapsules were engineered and examined in vitro and in vivo in two human intervention studies (bioavailability study and proof-of-concept/safety study)...
March 2018: Diabetes Care
https://www.readbyqxmd.com/read/29100430/novel-naprt-specific-antibody-identifies-small-cell-lung-cancer-and-neuronal-cancers-as-promising-clinical-indications-for-a-nampt-inhibitor-niacin-co-administration-strategy
#7
Jonathan Cole, Marie-Christine Guiot, Michel Gravel, Cynthia Bernier, Gordon C Shore, Anne Roulston
Tumor cells are particularly dependent on NAD+ due to higher rates of metabolism, DNA synthesis and repair. Nicotinamide phosphoribosyltransferase inhibitors (NAMPTis) inhibit NAD+ biosynthesis and represent promising new anti-cancer agents. However, clinical efficacy has been limited by toxicities demonstrating the need for drug combinations to broaden the therapeutic index. One potential combination involves niacin/NAMPTi co-administration. Niacin can rescue NAD+ biosynthesis through a parallel pathway that depends on nicotinic acid phosphoribosyltransferase (NAPRT) expression...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29072717/stable-isotope-labeling-by-essential-nutrients-in-cell-culture-silec-for-accurate-measurement-of-nicotinamide-adenine-dinucleotide-metabolism
#8
David W Frederick, Sophie Trefely, Alexia Buas, Jason Goodspeed, Jay Singh, Clementina Mesaros, Joseph A Baur, Nathaniel W Snyder
Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are conserved metabolic cofactors that mediate reduction-oxidation (redox) reactions throughout all domains of life. The diversity of synthetic routes and cellular processes involving the transfer of reducing equivalents to and from these cofactors makes the accurate quantitation and metabolic tracing of NAD(H) and NADP(H) of broad interest. However, current analytical techniques typically rely on standard curves that do not incorporate confounding effects of the sample matrix...
November 20, 2017: Analyst
https://www.readbyqxmd.com/read/28792876/nad-deficiency-congenital-malformations-and-niacin-supplementation
#9
Hongjun Shi, Annabelle Enriquez, Melissa Rapadas, Ella M M A Martin, Roni Wang, Julie Moreau, Chai K Lim, Justin O Szot, Eddie Ip, James N Hughes, Kotaro Sugimoto, David T Humphreys, Aideen M McInerney-Leo, Paul J Leo, Ghassan J Maghzal, Jake Halliday, Janine Smith, Alison Colley, Paul R Mark, Felicity Collins, David O Sillence, David S Winlaw, Joshua W K Ho, Gilles J Guillemin, Matthew A Brown, Kazu Kikuchi, Paul Q Thomas, Roland Stocker, Eleni Giannoulatou, Gavin Chapman, Emma L Duncan, Duncan B Sparrow, Sally L Dunwoodie
BACKGROUND: Congenital malformations can be manifested as combinations of phenotypes that co-occur more often than expected by chance. In many such cases, it has proved difficult to identify a genetic cause. We sought the genetic cause of cardiac, vertebral, and renal defects, among others, in unrelated patients. METHODS: We used genomic sequencing to identify potentially pathogenic gene variants in families in which a person had multiple congenital malformations...
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28736097/alcoholic-pellagra-as-a-cause-of-altered-mental-status-in-the-emergency-department
#10
Sarah Kyuragi Luthe, Ryota Sato
BACKGROUND: Pellagra, which is caused by a deficiency of niacin and tryptophan, the precursor of niacin, is a rare disease in developed countries where alcoholism is a major risk factor due to malnutrition and lack of B vitamins. Although pellagra involves treatable dementia and psychosis, it is often underdiagnosed, especially in developed countries. CASE REPORT: In Japan, a 37-year-old man presented to the emergency department with altered mental status and seizures...
October 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28722260/effect-of-long-distance-transportation-on-serum-metabolic-profiles-of-steer-calves
#11
Satoshi Takemoto, Shozo Tomonaga, Masayuki Funaba, Tohru Matsui
Long-distance transportation is sometimes inevitable in the beef industry because of the geographic separation of major breeding and fattening areas. Long-distance transportation negatively impacts production and health of cattle, which may, at least partly, result from the disturbance of metabolism during and after transportation. However, alteration of metabolism remains elusive in transported cattle. We investigated the effects of transportation on the metabolomic profiles of Holstein steer calves. Non-targeted analysis of serum concentrations of low molecular weight metabolites was performed by gas chromatography mass spectrometry...
December 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28541582/definition-of-a-tolerable-upper-intake-level-of-niacin-a-systematic-review-and-meta-analysis-of-the-dose-dependent-effects-of-nicotinamide-and-nicotinic-acid-supplementation
#12
Clara Minto, Maria Gabriella Vecchio, Manfred Lamprecht, Dario Gregori
Context: Nicotinic acid and nicotinamide are soluble compounds of the vitamin B group, widely used to regulate the lipid profile in hyperlipidemic individuals. Higher doses of nicotinic acid are associated with adverse effects, especially flushing. A unique tolerable upper intake level (UL) of nicotinic acid has not been defined. Objective: This meta-analysis aims to evaluate adverse effects and their incidence after supplementation with different doses of nicotinic acid and nicotinamide, comparing results with current ULs in Europe and the United States...
June 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28473059/nicotinamide-protects-hepatocytes-against-palmitate-induced-lipotoxicity-via-sirt1-dependent-autophagy-induction
#13
Chen Shen, Xiaobing Dou, Yue Ma, Wang Ma, Songtao Li, Zhenyuan Song
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism remains to be clearly elucidated. Palmitate is the most abundant SFA in the circulation and major lipotoxic inducer. Accumulating evidence supports that autophagy induction is protective against palmitate-induced cell death in a variety of cell types, including hepatocytes. Nicotinamide is the amide form of nicotinic acid (vitamin B3, Niacin) and a dietary supplementation as a source of vitamin B3...
April 2017: Nutrition Research
https://www.readbyqxmd.com/read/28464103/comparison-of-plasma-tryptophan-related-metabolites-in-crossbred-pi%C3%A3-train-and-duroc-pigs
#14
N Le Floc'h, A Simongiovanni, E Corrent, J J Matte
Besides being incorporated into proteins, Trp, an indispensable AA, is involved in numerous metabolic pathways. Previous data showed that Trp conversion into kynurenine (Kyn) and nicotinamide (Nam) differs among studies, and such differences cannot be explained by different dietary niacin supplies. We hypothesized that pig genotype influences Trp metabolism and thus the conversion of Trp into its metabolites. The objective of this study was to compare plasma appearance of Trp and related metabolites in 12 Duroc and 12 Piétrain crossbred postweaning pigs fed 2 contrasting dietary Trp levels...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28337428/niacin-mediated-gene-expression-and-role-of-niar-as-a-transcriptional-repressor-of-niax-nadc-and-pnuc-in-streptococcus-pneumoniae
#15
Muhammad Afzal, Oscar P Kuipers, Sulman Shafeeq
NAD (Nicotinamide Adenine Dinucleotide) biosynthesis is vital for bacterial physiology and plays an important role in cellular metabolism. A naturally occurring vitamin B complex, niacin (nicotinic acid), is a precursor of coenzymes NAD and NADP. Here, we study the impact of niacin on global gene expression of Streptococcus pneumoniae D39 and elucidate the role of NiaR as a transcriptional regulator of niaX, nadC, and pnuC. Transcriptome comparison of the D39 wild-type grown in chemically defined medium (CDM) with 0 to 10 mM niacin revealed elevated expression of various genes, including niaX, nadC, pnuC, fba, rex, gapN, pncB, gap, adhE, and adhB2 that are putatively involved in the transport and utilization of niacin...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28111310/niacin-intake-and-incident-adult-onset-atopic-dermatitis-in-women
#16
Aaron M Drucker, Wen-Qing Li, Min Kyung Park, Tricia Li, Abrar A Qureshi, Eunyoung Cho
No abstract text is available yet for this article.
June 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27592202/tissue-specific-regulation-of-sirtuin-and-nicotinamide-adenine-dinucleotide-biosynthetic-pathways-identified-in-c57bl-6-mice-in-response-to-high-fat-feeding
#17
COMPARATIVE STUDY
Janice E Drew, Andrew J Farquharson, Graham W Horgan, Lynda M Williams
The sirtuin (SIRT)/nicotinamide adenine dinucleotide (NAD) system is implicated in development of type 2 diabetes (T2D) and diet-induced obesity, a major risk factor for T2D. Mechanistic links have not yet been defined. SIRT/NAD system gene expression and NAD/NADH levels were measured in liver, white adipose tissue (WAT) and skeletal muscle from mice fed either a low-fat diet or high-fat diet (HFD) for 3 days up to 16 weeks. An in-house custom-designed multiplex gene expression assay assessed all 7 mouse SIRTs (SIRT1-7) and 16 enzymes involved in conversion of tryptophan, niacin, nicotinamide riboside and metabolic precursors to NAD...
November 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27567458/comparison-of-the-effects-of-nicotinic-acid-and-nicotinamide-degradation-on-plasma-betaine-and-choline-levels
#18
Wu-Ping Sun, Ming-Zhu Zhai, Da Li, Yiming Zhou, Na-Na Chen, Ming Guo, Shi-Sheng Zhou
AIM: The present study was to compare the effects of nicotinic acid and nicotinamide on the plasma methyl donors, choline and betaine. METHODS: Thirty adult subjects were randomly divided into three groups of equal size, and orally received purified water (C group), nicotinic acid (300 mg, NA group) or nicotinamide (300 mg, NM group). Plasma nicotinamide, N(1)-methylnicotinamide, homocysteine, betaine and choline levels before and 1.5-h and 3-h post-dosing, plasma normetanephrine and metanephrine concentrations at 3-h post-dosing, and the urinary excretion of N(1)-methyl-2-pyridone-5-carboxamide during the test period were examined...
August 10, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27529289/neurodegeneration-in-equine-grass-sickness-is-not-attributable-to-niacin-deficiency
#19
B C McGorum, R C Jago, E Cillan-Garcia, R S Pirie, J A Keen, R J M Reardon, P Y Saffu, N J Miller
BACKGROUND: The aetiology of equine grass sickness (EGS) is currently unknown. We hypothesised that an acute deficiency of niacin (vitamin B3), which plays a key role in neural homeostasis, may contribute to neurodegeneration in EGS. Niacin deficiency can potentially result from ingestion of niacin antagonists produced by pasture mycotoxigenic fungi. OBJECTIVES: To compare the niacin status of EGS and control grazing horses. A secondary objective was to compare blood concentrations of vitamins B1, B2 and B6 in EGS and control grazing horses to determine if the status of these vitamins was altered in EGS...
July 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/27491713/pellagra-secondary-to-medication-and-alcoholism-a-case-report-and-review-of-the-literature
#20
Rongrong Li, Kang Yu, Qiang Wang, Lilin Wang, Jiangfeng Mao, Jiaming Qian
Pellagra usually results from niacin deficiency and presents with the classic triad of dermatitis, diarrhea, and dementia. It is most commonly associated with malnutrition and poverty and is extremely rare in industrialized societies. Furthermore, pellagra can be induced by special clinical conditions that interfere with the intake, absorption, and metabolism of niacin. Because of its detrimental effects on health and its favorable prognosis after supplementation of nicotinamide, the importance of early diagnosis and treatment should be emphasized...
August 4, 2016: Nutrition in Clinical Practice
keyword
keyword
96311
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"