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https://www.readbyqxmd.com/read/28498256/paragon-anzgog-0903-phase-2-study-of-anastrozole-in-women-with-estrogen-or-progesterone-receptor-positive-platinum-resistant-or-refractory-recurrent-ovarian-cancer
#1
Anthony Bonaventura, Rachel L OʼConnell, Cristina Mapagu, Philip J Beale, Orla M McNally, Linda R Mileshkin, Peter T Grant, Alison M Hadley, Jeffery C H Goh, Katrin M Sjoquist, Julie Martyn, Anna DeFazio, James Scurry, Michael L Friedlander
BACKGROUND: There is some evidence that a subset of patients with recurrent ovarian cancer may benefit from antiestrogen therapy. The Paragon study is a basket protocol that includes a series of phase 2 trials investigating the activity of anastrozole in patients with estrogen or progesterone receptor-positive recurrent gynecological cancers. We report the results of treatment in patients with platinum-resistant or -refractory recurrent epithelial ovarian cancer. METHODS: Postmenopausal women who had estrogen and/or progesterone receptor-positive platinum-resistant or platinum-refractory recurrent ovarian cancer and disease measurable by Response Evaluation Criteria In Solid Tumors (RECIST) version 1...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28489317/pharmacogenomics-of-angiotensin-receptor-neprilysin-inhibitor-and-its-long-term-side-effects
#2
REVIEW
Chayakrit Krittanawong, Takeshi Kitai
The development of the promising agent sacubitril/valsartan, known as an angiotensin receptor blocker-neprilysin inhibitor (ARNI), to improve heart failure (HF) management, may benefit morbidity, mortality, and readmission rates in patients with HF. The PARADIGM-HF trial demonstrated that the ARNI can reduce morbidity and mortality in patients with heart failure with reduced ejection fraction (HFrEF), while ongoing PARAMOUNT and PARAGON-HF trials determined whether the ARNI has morbidity and mortality benefits in patients with heart failure with preserved ejection fraction (HFpEF)...
May 10, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28434933/assessing-the-eligibility-criteria-in-phase-iii-randomized-controlled-trials-of-drug-therapy-in-heart-failure-with-preserved-ejection-fraction-the-critical-play-off-between-a-pure-patient-phenotype-and-the-generalizability-of-trial-findings
#3
Hitesh C Patel, Carl Hayward, Jason Dungu, Sofia Papadopoulou, Abdel Saidmeerasah, Carlo Di Mario, Nesan Shanmugam, Martin R Cowie, Lisa J Anderson
AIMS: To investigate the effect of the different eligibility criteria used by phase III clinical studies in heart failure with preserved ejection fraction (HFpEF) on patient selection, phenotype and survival. METHODS AND RESULTS: We applied the key eligibility criteria of seven phase III HFpEF studies (DIG-Ancillary, CHARM-Preserved, PEP-CHF, I-PRESERVE, J-DHF, TOPCAT and PARAGON-HF [on-going]) to a typical and well-characterised HFpEF population (n=557) seen in modern European cardiological practice...
April 18, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28390540/student-personality-and-learning-styles-a-comparison-between-radiation-therapy-and-medical-imaging-undergraduate-students-in-new-zealand
#4
G Dungey, J Yielder
This study investigated the learning styles and personality type of undergraduate radiation therapy students at the University of Otago, Wellington (UOW) in New Zealand (NZ) to ascertain whether there is a pattern evidenced for this group and how that might compare with NZ medical imaging students. All students enrolled in the first year of the Bachelor of Radiation Therapy degree from 2014 to 2016 at the UOW were invited to participate in this research. The test tool was the Paragon Learning Style Inventory (PLSI), which is a standardised questionnaire adapted from the Myers-Briggs Type Indicator (MBTI)...
May 2017: Radiography
https://www.readbyqxmd.com/read/28295651/the-cremasteric-reflex-and-its-muscle-a-paragon-of-ongoing-scientific-discussion-a-systematic-review
#5
Gilbert M Schwarz, Lena Hirtler
The technique of triggering the cremasteric reflex and its respective signaling pathway is not described uniformly throughout the literature. As this reflex is a useful sign in diagnosing testicular torsion, orchitis, varicocele, and undescended testis, it seems desirable to identify and define the correct mechanism. Our aim was to investigate how the cremasteric reflex and its signaling pathway are described in the current literature and how the variability of the innervation of the inguinal region could affect the frequency of this reflex...
March 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28264956/primary-health-care-that-works-the-costa-rican-experience
#6
Madeline Pesec, Hannah L Ratcliffe, Ami Karlage, Lisa R Hirschhorn, Atul Gawande, Asaf Bitton
Long considered a paragon among low- and middle-income countries in its provision of primary health care, Costa Rica reformed its primary health care system in 1994 using a model that, despite its success, has been generally understudied: basic integrated health care teams. This case study provides a detailed description of Costa Rica's innovative implementation of four critical service delivery reforms and explains how those reforms supported the provision of the four essential functions of primary health care: first-contact access, coordination, continuity, and comprehensiveness...
March 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28213475/wheat-landrace-genome-diversity
#7
Luzie U Wingen, Claire West, Michelle Leverington-Waite, Sarah Collier, Simon Orford, Richard Goram, Cai-Yun Yang, Julie King, Alexandra M Allen, Amanda Burridge, Keith J Edwards, Simon Griffiths
Understanding the genomic complexity of bread wheat (Triticum aestivum L.) is a cornerstone in the quest to unravel the processes of domestication and the following adaptation of domesticated wheat to a wide variety of environments across the globe. Additionally, it is of importance for future improvement of the crop, particularly in the light of climate change. Focusing on the adaptation after domestication, a nested association mapping (NAM) panel of 60 segregating biparental populations was developed, mainly involving landrace accessions from the core set of the Watkins hexaploid wheat collection optimized for genetic diversity...
April 2017: Genetics
https://www.readbyqxmd.com/read/28179910/temporally-and-genetically-discrete-periods-of-wheat-sensitivity-to-high-temperature
#8
Henry M Barber, Martin Lukac, James Simmonds, Mikhail A Semenov, Mike J Gooding
Successive single day transfers of pot-grown wheat to high temperature (35/30°C day/night) replicated controlled environments, from the second node detectable to the milky-ripe growth stages, provides the strongest available evidence that the fertility of wheat can be highly vulnerable to heat stress during two discrete peak periods of susceptibility: early booting [decimal growth stage (GS) 41-45] and early anthesis (GS 61-65). A double Gaussian fitted simultaneously to grain number and weight data from two contrasting elite lines (Renesansa, listed in Serbia, Ppd-D1a, Rht8; Savannah, listed in UK, Ppd-D1b, Rht-D1b) identified peak periods of main stem susceptibility centered on 3 (s...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27937057/radical-cystectomy-do-we-need-standardization
#9
Christian Ladurner, Evi Comploj, Emanuela Trenti, Salvatore Palermo, Alexander Pycha, Armin Pycha
The first series of radical cystectomy with a definition of surgical landmarks was published in 1949 and was characterized by a high perioperative mortality and a 5-year survival rate around 50%. Decades later, nevertheless many surgical progresses were made and the perioperative mortality dropped to 2,5%, this had not lead to an improvement of long term survival rates, also because a standardization of the procedure is still missing. Areas covered: Radical cystectomy is performed with different surgical techniques obmitting a standardization...
December 28, 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27909984/prof-shuch%C3%A3-n-teng-a-paragon-taxonomist-of-great-passion-and-firm-belief
#10
Guojie Li
No abstract text is available yet for this article.
December 1, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27861262/tear-film-osmolarity-in-response-to-long-term-orthokeratology-treatment
#11
Amelia Nieto-Bona, María Nombela-Palomo, Gema Felipe-Márquez, Miguel A Teus
PURPOSE: To compare tear film osmolarity (TFO) measurements in non-contact lens (CL) wearers and wearers of hydrogel or overnight orthokeratology (OK) CLs, and to assess possible effects of long-term OK on TFO. METHODS: Overall, 108 subjects with moderate myopia participated in 2 experiments, and TFO was measured using the TearLab osmolarity system. In experiment 1, TFO measurements were made in 77 right eyes of 23 non-CL wearers, 26 hydrogel wearers, and 28 OK wearers...
November 16, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27561844/paragon-ii-a-single-arm-multicentre-phase-ii-study-of-neoadjuvant-therapy-using-irinotecan-bead-in-patients-with-resectable-liver-metastases-from-colorectal-cancer
#12
MULTICENTER STUDY
R P Jones, H Z Malik, S W Fenwick, M Terlizzo, E O'Grady, S Stremitzer, T Gruenberger, M Rees, G Plant, J Figueras, M Albiol, R Adam, S Awad, G J Poston
PURPOSE: Perioperative chemotherapy confers a 3-year progression free survival advantage following resection of colorectal liver metastases (CRLM), but is associated with significant toxicity. Chemoembolisation using drug eluting PVA microspheres loaded with irinotecan (DEBIRI) allows sustained delivery of drug directly to tumour, maximising response whilst minimising systemic exposure. This phase II single arm study examined the safety and feasibility of DEBIRI before resection of CRLM...
December 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27499488/acid-brothers-henry-beecher-timothy-leary-and-the-psychedelic-of-the-century
#13
Jonathan D Moreno
Henry Knowles Beecher, an icon of human research ethics, and Timothy Francis Leary, a guru of the counterculture, are bound together in history by the synthetic hallucinogen lysergic acid diethylamide (LSD). Both were associated with Harvard University during a critical period in their careers and of drastic social change. To all appearances the first was a paragon of the establishment and a constructive if complex hero, the second a rebel and a criminal, a rogue and a scoundrel. Although there is no evidence they ever met, Beecher's indirect struggle with Leary over control of the 20th century's most celebrated psychedelic was at the very heart of his views about the legitimate, responsible investigator...
2016: Perspectives in Biology and Medicine
https://www.readbyqxmd.com/read/27460274/from-the-immoral-to-the-incorruptible-how-prescriptive-expectations-turn-the-powerful-into-paragons-of-virtue
#14
Miao Hu, Derek D Rucker, Adam D Galinsky
Ample evidence documents that power increases unethical behavior. This article introduces a new theoretical framework for understanding when power leads to more versus less unethical behavior. Our key proposition is that people hold expectations about power that are both descriptive (how the powerful do behave) and prescriptive (how the powerful should behave). People hold descriptive beliefs that the powerful do behave more unethically than the powerless, but they hold prescriptive beliefs that the powerful should behave more ethically than the powerless...
2016: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/27305878/the-history-of-multimodal-treatment-of-wilms-tumor
#15
Don K Nakayama, Patrick C Bonasso
Multimodal therapy-surgery, radiation therapy, and chemotherapy-the foundation of modern cancer treatment, has led to dramatic improvements in survival. How the three disciplines coalesced to conquer Wilms' tumor is a compelling story that includes two of history's greatest discoveries, X-rays and antibiotics. By the mid-20th century both fields had matured to where dedicated clinicians and creative scientists could apply them to Wilms' tumor and achieve successive improvements in survival. William Ladd was able to achieve a zero operative mortality by 1940, but was left with a 32 per cent survival with surgery alone...
June 2016: American Surgeon
https://www.readbyqxmd.com/read/27243354/short-term-effects-of-overnight-orthokeratology-on-corneal-sub-basal-nerve-plexus-morphology-and-corneal-sensitivity
#16
María Nombela-Palomo, Gema Felipe-Marquez, Jose Luis Hernandez-Verdejo, Amelia Nieto-Bona
OBJECTIVE: To assess the effects of a short period of orthokeratology (OK) on corneal subbasal nerve plexus (SBNP) morphology and corneal sensitivity. METHODS: Measurements were made in 56 right eyes of 56 subjects with low-to-moderate myopia who wore 2 OK lens designs (Group CRT: HDS 100 Paragon CRT, n=35; Group SF: Seefree; n=21) for a period of 1 month and in 15 right eyes of noncontact lens wearers as controls. The variables determined in each participant were corneal sensitivity using a Cochet-Bonnet esthesiometer and 12 SBNP variables determined on laser scanning confocal microscopy images using 3 different software packages...
May 26, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27232901/the-influence-of-different-ok-lens-designs-on-peripheral-refraction
#17
Pauline Kang, Helen Swarbrick
PURPOSE: To compare peripheral refraction changes along the horizontal and vertical meridians induced by three different orthokeratology (OK) lens designs: BE, Paragon CRT, and Contex lenses. METHODS: Nineteen subjects (6M, 13F, mean age 28 ± 7 years) were initially fitted with BE OK lenses in both eyes which were worn overnight for 14 days. Central and peripheral refraction and corneal topography were measured at baseline and after 14 nights of lens wear. After a minimum 2-week washout period, one randomly selected eye was re-fitted with a Paragon CRT lens and the other eye with a Contex OK lens...
September 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27208902/physiologic-and-acoustic-effects-of-opera-performance
#18
Paul E Kwak, C Richard Stasney, Jeremy R Hathway, Danielle Guffey, Charles G Minard, Julina Ongkasuwan
INTRODUCTION/HYPOTHESIS: Opera performance is physiological and emotional, and singing performers utilize their larynges in often strenuous ways. Historically, the training of a classical voice has been considered the paragon of healthy singing. However, the natural history of a performing larynx has not been studied systematically. There is paucity of scientific studies to guide practice patterns, particularly with regard to the course and extent of post-performance physiologic and acoustic changes...
January 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/26873036/combining-angiotensin-ii-receptor-1-antagonism-and-neprilysin-inhibition-for-the-treatment-of-heart-failure
#19
Spyridon Katsanos, Vasiliki Bistola, John T Parissis
Sacubitril/valsartan is a novel, first-in-class drug, which combines a neprilysin inhibitor with an angiotensin receptor blocker. Sacubitril inhibits neprilysin endopeptidase, blocking the catabolism of natriuretic peptides (NP), thereby increasing their bioavailability. Valsartan counterbalances the increase of angiotensin II that results from neprilysin inhibition, exerting also the beneficial effects of angiotensin receptor blockers seen in previous HF trials. PARADIGM-HF trial has proved the superiority of sacubitril/valsartan (LCZ696) over ACE inhibitor enalapril to reduce mortality and morbidity of symptomatic HF patients with reduced ejection fraction (HFrEF), setting the grounds for the replacement of ACE inhibitors by sacubitril/valsartan in the management of HFrEF...
February 29, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/26816955/double-tension-band-osteosynthesis-in-inter-condylar-humeral-fractures
#20
Santosh Lakshmanrao Munde, Mohmmed Javed Bhatti, R C Siwach, Anil Gulia, Z S Kundu, Sanjeev Bansal, Sanjay Middha, Hemlata T Kamra
INTRODUCTION: Intercondylar humerus fractures are uncommon in orthopaedic practice. The treatment for the same has been described in the literature and include paragonal and orthogonal fixation by using plates. Tension band wiring as a treatment for the same is sparsely described in the literature. AIM: To evaluate the effectiveness of "Double Tension Band wiring" method for the treatment of intercondylar fractures of humerus and compare the results with studies involving treatment with locked plates...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
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