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https://www.readbyqxmd.com/read/29562296/dynamics-of-leaf-and-spikelet-primordia-initiation-in-wheat-as-affected-by-ppd-1a-alleles-under-field-conditions
#1
Helga Ochagavía, Paula Prieto, Roxana Savin, Simon Griffiths, Gustavo A Slafer
Wheat adaptation is affected by Ppd genes, but the role of these alleles on the rates of leaf and spikelet initiation has not been properly analysed. Twelve near isogenic lines (NILs) combining Ppd-1a alleles from different donors introgressed in A, B and/or D genomes were tested under field conditions during two growing seasons together with the wild type, Paragon. Leaf initiation rate was unaffected by Ppd-1a alleles so final leaf number (FLN) was reduced in parallel with reductions in the duration of vegetative phase...
March 17, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29489498/analysis-of-two-orthokeratology-lens-designs-and-comparison-of-their-optical-effects-on-the-cornea
#2
Rémy Marcotte-Collard, Patrick Simard, Langis Michaud
PURPOSE: This study aims to analyze two commercial orthokeratology lens designs and compare their optical effects at the corneal level. METHODS: This is a retrospective study on subjects seeking an orthokeratology fitting for myopia management at the Université de Montréal clinic between January 2013 and August 2015. Group A included the first 64 subjects fitted with a 4-curve lens design (Paragon CRT; Paragon) who met the inclusion criteria, whereas group B included the same number of subjects fitted with a 5-curve lens design (Dreamlens; Polymer Technology, Rochester, NY)...
February 27, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29473675/contemporary-oxygenator-design-shear-stress-related-oxygen-and-carbon-dioxide-transfer
#3
Rik H J Hendrix, Yuri M Ganushchak, Patrick W Weerwind
Design of contemporary oxygenators requires better understanding of the influence of hydrodynamic patterns on gas exchange. A decrease in blood path width or an increase in intraoxygenator turbulence for instance, might increase gas transfer efficiency but it will increase shear stress as well. The aim of this clinical study was to examine the association between shear stress and oxygen and carbon dioxide transfer in different contemporary oxygenators during cardiopulmonary bypass (CPB). The effect of additional parameters related to gas transfer efficiency, that is, blood flow, gas flow, sweep gas oxygen fraction (FiO2 ), hemoglobin concentration, the amount of hemoglobin pumped through the oxygenator per minute-Qhb, and shunt fraction were contemplated as well...
February 23, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29440812/-personified-as-paragon-of-suffering-optimistic-being-of-achieving-normalcy-a-conceptual-model-derived-from-qualitative-research
#4
Shalini G Nayak, Mamatha Shivananda Pai, Linu Sara George
Background: Conceptual models developed through qualitative research are based on the unique experiences of suffering and individuals' adoptions of each participant. A wide array of problems are faced by head-and-neck cancer (HNC) patients due to disease pathology and treatment modalities which are sufficient to influence the quality of life (QOL). Men possess greater self-acceptance and are better equipped with intrapersonal strength to cope with stress and adequacy compared to women...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29420576/relative-age-effect-in-elite-soccer-more-early-born-players-but-no-better-valued-and-no-paragon-clubs-or-countries
#5
John R Doyle, Paul A Bottomley
The paper analyses two datasets of elite soccer players (top 1000 professionals and UEFA Under-19 Youth League). In both, we find a Relative Age Effect (RAE) for frequency, but not for value. That is, while there are more players born at the start of the competition year, their transfer values are no higher, nor are they given more game time. We use Poisson regression to derive a transparent index of the discrimination present in RAE. Also, because Poisson is valid for small frequency counts, it supports analysis at the disaggregated levels of country and club...
2018: PloS One
https://www.readbyqxmd.com/read/29403642/characterisation-of-the-french-ferret-population-husbandry-reported-medical-care-and-feeding-habits
#6
Géraldine Blanchard, Maud Marsot, Roselyne Bourassin, Bernard-Marie Paragon, Jean-Jacques Benet, Adeline Linsart
Ferrets have become a common companion animal. But no data are available on the French population of ferrets. The goal of the survey was to characterise this population, including demographic characteristics, husbandry, reported medical care and feeding habits. Complete data were available for 1205 pet ferrets in 709 households. Most ferrets (86·1 %) lived indoors, 1 % received only artificial lighting, and 47 % chewed their cage. For 60 % of the ferrets, body weight was higher in winter and lower in summer...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29249426/par-4-the-paragon-of-protease-activated-receptors
#7
EDITORIAL
Tobias Geisler
No abstract text is available yet for this article.
February 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29223747/an-automated-high-throughput-system-for-phenotypic-screening-of-chemical-libraries-on-c-elegans-and-parasitic-nematodes
#8
Frederick A Partridge, Anwen E Brown, Steven D Buckingham, Nicky J Willis, Graham M Wynne, Ruth Forman, Kathryn J Else, Alison A Morrison, Jacqueline B Matthews, Angela J Russell, David A Lomas, David B Sattelle
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global threat. We have developed an INVertebrate Automated Phenotyping Platform (INVAPP) for high-throughput, plate-based chemical screening, and an algorithm (Paragon) which allows screening for compounds that have an effect on motility and development of parasitic worms...
December 2, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29220606/why-walk%C3%A2-fly-managing-anger-grief-and-ptsd-2016-by-frances-helusky-221-pp-soft-cover-isbn-9780966263114-paragon-counseling-inc-co-published-with-virtualbookworm-com-publishing-college-station-tx-price-17-95
#9
https://www.readbyqxmd.com/read/29216335/introgression-of-aegilops-speltoides-segments-in-triticum-aestivum-and-the-effect-of-the-gametocidal-genes
#10
Julie King, Surbhi Grewal, Cai-Yun Yang, Stella Hubbart Edwards, Duncan Scholefield, Stephen Ashling, John A Harper, Alexandra M Allen, Keith J Edwards, Amanda J Burridge, Ian P King
Background and Aims: Bread wheat (Triticum aestivum) has been through a severe genetic bottleneck as a result of its evolution and domestication. It is therefore essential that new sources of genetic variation are generated and utilized. This study aimed to generate genome-wide introgressed segments from Aegilops speltoides. Introgressions generated from this research will be made available for phenotypic analysis. Methods: Aegilops speltoides was crossed as the male parent to T...
February 12, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29172858/why-walk%C3%A2-fly-managing-anger-grief-and-ptsd-2016-by-frances-helusky-221-pp-soft-cover-isbn-9780966263114-paragon-counseling-inc-co-published-with-virtualbookworm-com-publishing-college-station-tx-price-17-95
#11
https://www.readbyqxmd.com/read/29099990/transfer-of-a-starch-phenotype-from-wild-wheat-to-bread-wheat-by-deletion-of-a-locus-controlling-b-type-starch-granule-content
#12
Tansy Chia, Nikolai M Adamski, Benedetta Saccomanno, Andy Greenland, Alastair Nash, Cristobal Uauy, Kay Trafford
Our previous genetic analysis of a tetraploid wild wheat species, Aegilops peregrina, predicted that a single gene per haploid genome, Bgc-1, controls B-type starch granule content in the grain. To test whether bread wheat (Triticum aestivum L.) has orthologous Bgc-1 loci, we screened a population of γ-irradiated bread wheat cv. Paragon for deletions of the group 4 chromosomes spanning Bgc-1. Suitable deletions, each encompassing ~600-700 genes, were discovered for chromosomes 4A and 4D. These two deletions are predicted to have 240 homoeologous genes in common...
November 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29046689/an-updated-protocol-for-high-throughput-plant-tissue-sectioning
#13
Jonathan A Atkinson, Darren M Wells
Quantification of the tissue and cellular structure of plant material is essential for the study of a variety of plant sciences applications. Currently, many methods for sectioning plant material are either low throughput or involve free-hand sectioning which requires a significant amount of practice. Here, we present an updated method to provide rapid and high-quality cross sections, primarily of root tissue but which can also be readily applied to other tissues such as leaves or stems. To increase the throughput of traditional agarose embedding and sectioning, custom designed 3D printed molds were utilized to embed 5-15 roots in a block for sectioning in a single cut...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28967307/introduction-surgical-management-of-skull-base-meningiomas
#14
Gabriel Zada, Mustafa K Başkaya, Mitesh V Shah
Meningiomas represent the most common primary intracranial neoplasm treated by neurosurgeons. Although multimodal treatment of meningiomas includes surgery, radiation-based treatments, and occasionally medical therapy, surgery remains the mainstay of treatment for most symptomatic meningiomas. Because of the intricate relationship of the dura mater and arachnoid mater with the central nervous system and cranial nerves, meningiomas can arise anywhere along the skull base or convexities, and occasionally even within the ventricular system, thereby mandating a catalog of surgical approaches that neurosurgeons may employ to individualize treatment for patients...
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28865110/the-effect-of-photodamage-on-the-female-caucasian-facial-stratum-corneum-corneome-using-mass-spectrometry-based-proteomics
#15
R Voegeli, J-M Monneuse, R Schoop, B Summers, A V Rawlings
BACKGROUND: The effect of photodamage on facial stratum corneum (SC) is still poorly understood. OBJECTIVE: To describe the SC proteome from tape strippings of Caucasian SC from photoexposed cheek and photoprotected post-auricular (PA) site, a global analysis of photodamage on the skin will be developed leading to a better understanding of keratinocyte signalling pathways and identification of new molecular targets for the treatment of photoaged skin. METHODS: Female Caucasian subjects had nine consecutive tape strippings taken from their cheeks and PA site...
September 2, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28799859/why-walk%C3%A2-fly-managing-anger-grief-and-ptsd-2016-by-frances-helusky-221-pp-soft-cover-isbn-9780966263114-paragon-counseling-inc-co-published-with-virtualbookworm-com-publishing-college-station-tx-price-17-95
#16
https://www.readbyqxmd.com/read/28662936/angiotensin-receptor-neprilysin-inhibition-in-heart-failure-with-preserved-ejection-fraction-rationale-and-design-of-the-paragon-hf-trial
#17
REVIEW
Scott D Solomon, Adel R Rizkala, Jianjian Gong, Wenyan Wang, Inder S Anand, Junbo Ge, Carolyn S P Lam, Aldo P Maggioni, Felipe Martinez, Milton Packer, Marc A Pfeffer, Burkert Pieske, Margaret M Redfield, Jean L Rouleau, Dirk J Van Veldhuisen, Faiez Zannad, Michael R Zile, Akshay S Desai, Victor C Shi, Martin P Lefkowitz, John J V McMurray
OBJECTIVES: The PARAGON-HF (Prospective Comparison of ARNI with ARB Global Outcomes in HF With Preserved Ejection Fraction) trial is designed to determine the efficacy and safety of the angiotensin receptor neprilysin inhibitor sacubitril/valsartan compared with valsartan in patients with chronic heart failure and preserved ejection fraction (HFpEF). BACKGROUND: HFpEF is highly prevalent, associated with substantial morbidity and mortality, and in need of effective therapies that improve outcomes...
July 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28644699/why-walk%C3%A2-fly-managing-anger-grief-and-ptsd-2016-by-frances-helusky-221-pp-soft-cover-isbn-9780966263114-paragon-counseling-inc-co-published-with-virtualbookworm-com-publishing-college-station-tx-price-17-95
#18
https://www.readbyqxmd.com/read/28636269/commentary-on-r-d-trends-away-from-general-medicine-cardiovascular-drugs-can-the-fda-help-reverse-the-trend
#19
REVIEW
R J Meyer
In the latter part of the 20th century, drug development in cardiovascular diseases (CVDs) was a paragon of "modern" therapeutics, bringing about a substantial number of effective, well-tolerated agents targeting some of the most prevalent diseases of the Western world. These drugs were often examples of rational drug development targeting specific pathophysiologic pathways previously elucidated through basic research (e.g., targeting of the renin-angiotensin system or the cholesterol synthesis pathway). The widespread adoption of these ground-breaking medications in practice and into medical guidelines undoubtedly played a role in the fall of morbidity and mortality from CVD in the United States in recent decades...
August 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28585184/text-mining-of-the-electronic-health-record-an-information-extraction-approach-for-automated-identification-and-subphenotyping-of-hfpef-patients-for-clinical-trials
#20
Siddhartha R Jonnalagadda, Abhishek K Adupa, Ravi P Garg, Jessica Corona-Cox, Sanjiv J Shah
Precision medicine requires clinical trials that are able to efficiently enroll subtypes of patients in whom targeted therapies can be tested. To reduce the large amount of time spent screening, identifying, and recruiting patients with specific subtypes of heterogeneous clinical syndromes (such as heart failure with preserved ejection fraction [HFpEF]), we need prescreening systems that are able to automate data extraction and decision-making tasks. However, a major obstacle is the vast amount of unstructured free-form text in medical records...
June 2017: Journal of Cardiovascular Translational Research
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